Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FIS1 Gene

Aliases for FIS1 Gene

  • Fission, Mitochondrial 1 2 3 5
  • Tetratricopeptide Repeat Protein 11 3 4
  • Tetratricopeptide Repeat Domain 11 2 3
  • Mitochondrial Fission Molecule 2 3
  • TPR Repeat Protein 11 3 4
  • FIS1 Homolog 3 4
  • TTC11 3 4
  • HFis1 3 4
  • Fission 1 (Mitochondrial Outer Membrane) Homolog (S. Cerevisiae) 2
  • Fission 1 (Mitochondrial Outer Membrane) Homolog (Yeast) 2
  • Fission 1 (Mitochondrial Outer Membrane) Homolog 3
  • CGI-135 Protein 2
  • H_NH0132A01.6 3
  • CGI-135 3

External Ids for FIS1 Gene

Previous HGNC Symbols for FIS1 Gene

  • TTC11

Previous GeneCards Identifiers for FIS1 Gene

  • GC07M100477
  • GC07M100665
  • GC07M100882
  • GC07M095475

Summaries for FIS1 Gene

Entrez Gene Summary for FIS1 Gene

  • The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FIS1 Gene

FIS1 (Fission, Mitochondrial 1) is a Protein Coding gene. Diseases associated with FIS1 include spinocerebellar ataxia 12 and optic atrophy plus syndrome. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for FIS1 Gene

  • Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

Gene Wiki entry for FIS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIS1 Gene

Genomics for FIS1 Gene

Regulatory Elements for FIS1 Gene

Promoters for FIS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FIS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FIS1 Gene

Chromosome:
7
Start:
101,239,458 bp from pter
End:
101,252,316 bp from pter
Size:
12,859 bases
Orientation:
Minus strand

Genomic View for FIS1 Gene

Genes around FIS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIS1 Gene

Proteins for FIS1 Gene

  • Protein details for FIS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D6-FIS1_HUMAN
    Recommended name:
    Mitochondrial fission 1 protein
    Protein Accession:
    Q9Y3D6
    Secondary Accessions:
    • Q9BTP3

    Protein attributes for FIS1 Gene

    Size:
    152 amino acids
    Molecular mass:
    16938 Da
    Quaternary structure:
    • Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5. Interacts with MIEF1. Interacts with PEX11A, PEX11B and PEX11G (PubMed:20826455).

    Three dimensional structures from OCA and Proteopedia for FIS1 Gene

neXtProt entry for FIS1 Gene

Proteomics data for FIS1 Gene at MOPED

Post-translational modifications for FIS1 Gene

Other Protein References for FIS1 Gene

Antibody Products

No data available for DME Specific Peptides for FIS1 Gene

Domains & Families for FIS1 Gene

Gene Families for FIS1 Gene

Protein Domains for FIS1 Gene

Suggested Antigen Peptide Sequences for FIS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3D6

UniProtKB/Swiss-Prot:

FIS1_HUMAN :
  • The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L.
  • Belongs to the FIS1 family.
  • Contains 1 TPR repeat.
Domain:
  • The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L.
Family:
  • Belongs to the FIS1 family.
Similarity:
  • Contains 1 TPR repeat.
genes like me logo Genes that share domains with FIS1: view

Function for FIS1 Gene

Molecular function for FIS1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
genes like me logo Genes that share phenotypes with FIS1: view

Animal Model Products

miRNA for FIS1 Gene

miRTarBase miRNAs that target FIS1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIS1 Gene

Localization for FIS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIS1 Gene

Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FIS1 Gene COMPARTMENTS Subcellular localization image for FIS1 gene
Compartment Confidence
mitochondrion 5
peroxisome 5
cytosol 4
endoplasmic reticulum 4
extracellular 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IEA,ISS 14561759
genes like me logo Genes that share ontologies with FIS1: view

Pathways & Interactions for FIS1 Gene

SuperPathways for FIS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission IMP 19864424
GO:0000422 mitophagy IDA 18515060
GO:0006626 protein targeting to mitochondrion IMP 18845145
GO:0008053 mitochondrial fusion IMP 23921378
GO:0016559 peroxisome fission IMP 20826455
genes like me logo Genes that share ontologies with FIS1: view

No data available for Pathways by source and SIGNOR curated interactions for FIS1 Gene

Drugs & Compounds for FIS1 Gene

(1) Additional Compounds for FIS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FIS1: view

Transcripts for FIS1 Gene

Unigene Clusters for FIS1 Gene

Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIS1 Gene

No ASD Table

Relevant External Links for FIS1 Gene

GeneLoc Exon Structure for
FIS1
ECgene alternative splicing isoforms for
FIS1

Expression for FIS1 Gene

mRNA expression in normal human tissues for FIS1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FIS1 Gene



SOURCE GeneReport for Unigene cluster for FIS1 Gene Hs.423968

genes like me logo Genes that share expression patterns with FIS1: view

Protein tissue co-expression partners for FIS1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FIS1 Gene

Orthologs for FIS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FIS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIS1 36
  • 100 (a)
OneToOne
FIS1 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia FIS1 35
  • 93.2 (n)
  • 97.37 (a)
FIS1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FIS1 36
  • 99 (a)
OneToOne
FIS1 35
  • 92.11 (n)
  • 98.68 (a)
mouse
(Mus musculus)
Mammalia Fis1 16
Fis1 36
  • 96 (a)
OneToOne
Fis1 35
  • 89.04 (n)
  • 96.05 (a)
oppossum
(Monodelphis domestica)
Mammalia FIS1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fis1 35
  • 89.46 (n)
  • 97.79 (a)
lizard
(Anolis carolinensis)
Reptilia FIS1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fis1 35
  • 72.41 (n)
  • 75.5 (a)
Str.10685 35
zebrafish
(Danio rerio)
Actinopterygii FIS1 36
  • 66 (a)
OneToOne
im:6905231 35
  • 64.43 (n)
  • 69.13 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009852 35
  • 56.37 (n)
  • 51.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fis1 35
  • 53.38 (n)
  • 49.32 (a)
Fis1 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fis-2 35
  • 48.95 (n)
  • 39.16 (a)
fis-1 36
  • 39 (a)
OneToMany
fis-2 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FIS1 36
  • 25 (a)
OneToOne
FIS1 38
Species with no ortholog for FIS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FIS1 Gene

ENSEMBL:
Gene Tree for FIS1 (if available)
TreeFam:
Gene Tree for FIS1 (if available)

Paralogs for FIS1 Gene

Pseudogenes.org Pseudogenes for FIS1 Gene

genes like me logo Genes that share paralogs with FIS1: view

No data available for Paralogs for FIS1 Gene

Variants for FIS1 Gene

Sequence variations from dbSNP and Humsavar for FIS1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs5886173 -- 101,244,996(+) AGCAC(-/G)GCCTC reference, frameshift-variant
rs7788201 -- 101,241,869(+) cagca(A/G)aattg intron-variant
rs6964812 -- 101,243,569(+) gactc(C/T)gtctc intron-variant
rs11540096 -- 101,244,104(+) GAGCC(C/T)GCTGC reference, synonymous-codon
rs12534065 -- 101,246,605(+) cgatt(A/C)tcttg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FIS1 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831075 CNV Loss 17160897
esv2422376 CNV Duplication 17116639
esv2752134 CNV Gain 17911159
nsv831076 CNV Loss 17160897
dgv7410n71 CNV Loss 21882294
esv2422326 CNV Duplication 17116639
nsv5875 CNV Insertion 18451855
nsv831077 CNV Loss 17160897

Variation tolerance for FIS1 Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIS1 Gene

HapMap Linkage Disequilibrium report
FIS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIS1 Gene

Disorders for FIS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FIS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 12
  • spinocerebellar ataxia type 12
optic atrophy plus syndrome
  • optic atrophy
optic nerve disease
  • disorder of optic nerve
- elite association - COSMIC cancer census association via MalaCards
Search FIS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FIS1

Genetic Association Database (GAD)
FIS1
Human Genome Epidemiology (HuGE) Navigator
FIS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FIS1
genes like me logo Genes that share disorders with FIS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FIS1 Gene

Publications for FIS1 Gene

  1. Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology. (PMID: 14996942) Stojanovski D. … Ryan M.T. (J. Cell Sci. 2004) 2 3 4 67
  2. Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1. (PMID: 20179104) Mai S. … Jendrach M. (J. Cell. Sci. 2010) 3 23
  3. Specific mitochondrial calcium overload induces mitochondrial fission in prostate cancer cells. (PMID: 20428767) Kaddour-Djebbar I. … Kumar M.V. (Int. J. Oncol. 2010) 3 23
  4. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. (PMID: 18353969) Gandre-Babbe S. … van der Bliek A.M. (Mol. Biol. Cell 2008) 3 23
  5. Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis. (PMID: 17408615) Kobayashi S. … Fujiki Y. (Exp. Cell Res. 2007) 3 23

Products for FIS1 Gene

Sources for FIS1 Gene

Back to Top

Content