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Aliases for FIS1 Gene

Aliases for FIS1 Gene

  • Fission 1 (Mitochondrial Outer Membrane) Homolog (S. Cerevisiae) 2 3
  • Tetratricopeptide Repeat Protein 11 3 4
  • Tetratricopeptide Repeat Domain 11 2 3
  • TPR Repeat Protein 11 3 4
  • FIS1 Homolog 3 4
  • TTC11 3 4
  • HFis1 3 4
  • Fission 1 (Mitochondrial Outer Membrane) Homolog (Yeast) 2
  • Mitochondrial Fission 1 Protein 3
  • CGI-135 Protein 2
  • H_NH0132A01.6 3
  • CGI-135 3
  • TTC11, 6

External Ids for FIS1 Gene

Previous HGNC Symbols for FIS1 Gene

  • TTC11

Previous GeneCards Identifiers for FIS1 Gene

  • GC07M100477
  • GC07M100665
  • GC07M100882
  • GC07M095475

Summaries for FIS1 Gene

Entrez Gene Summary for FIS1 Gene

  • The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FIS1 Gene

FIS1 (Fission 1 (Mitochondrial Outer Membrane) Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with FIS1 include spinocerebellar ataxia 12 and dental fluorosis. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for FIS1 Gene

  • Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

Gene Wiki entry for FIS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIS1 Gene

Genomics for FIS1 Gene

Regulatory Elements for FIS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FIS1 Gene

Start:
101,239,458 bp from pter
End:
101,252,316 bp from pter
Size:
12,859 bases
Orientation:
Minus strand

Genomic View for FIS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FIS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIS1 Gene

Proteins for FIS1 Gene

  • Protein details for FIS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D6-FIS1_HUMAN
    Recommended name:
    Mitochondrial fission 1 protein
    Protein Accession:
    Q9Y3D6
    Secondary Accessions:
    • Q9BTP3

    Protein attributes for FIS1 Gene

    Size:
    152 amino acids
    Molecular mass:
    16938 Da
    Quaternary structure:
    • Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5. Interacts with MIEF1.

    Three dimensional structures from OCA and Proteopedia for FIS1 Gene

neXtProt entry for FIS1 Gene

Proteomics data for FIS1 Gene at MOPED

Post-translational modifications for FIS1 Gene

Other Protein References for FIS1 Gene

No data available for DME Specific Peptides for FIS1 Gene

Domains for FIS1 Gene

Protein Domains for FIS1 Gene

Suggested Antigen Peptide Sequences for FIS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3D6

UniProtKB/Swiss-Prot:

FIS1_HUMAN :
  • Q9Y3D6
Domain:
  • The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L
Family:
  • Belongs to the FIS1 family.
Similarity:
  • Contains 1 TPR repeat.
genes like me logo Genes that share domains with FIS1: view

No data available for Gene Families for FIS1 Gene

Function for FIS1 Gene

Molecular function for FIS1 Gene

UniProtKB/Swiss-Prot Function: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

Gene Ontology (GO) - Molecular Function for FIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0005515 protein binding IPI 12861026
genes like me logo Genes that share ontologies with FIS1: view

Phenotypes for FIS1 Gene

genes like me logo Genes that share phenotypes with FIS1: view

Animal Model Products

CRISPR Products

miRNA for FIS1 Gene

miRTarBase miRNAs that target FIS1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FIS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FIS1 Gene

Localization for FIS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIS1 Gene

Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FIS1 Gene COMPARTMENTS Subcellular localization image for FIS1 gene
Compartment Confidence
mitochondrion 5
peroxisome 5
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005777 peroxisome ISS 14561759
GO:0005779 integral component of peroxisomal membrane IDA 16107562
GO:0016020 membrane IDA 19946888
GO:0031307 integral component of mitochondrial outer membrane NAS 18845145
genes like me logo Genes that share ontologies with FIS1: view

Pathways for FIS1 Gene

SuperPathways for FIS1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FIS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission IMP 19864424
GO:0000422 mitochondrion degradation IDA 18515060
GO:0001836 release of cytochrome c from mitochondria IMP 19864424
GO:0006626 protein targeting to mitochondrion IMP 18845145
GO:0007204 positive regulation of cytosolic calcium ion concentration IMP 21183955
genes like me logo Genes that share ontologies with FIS1: view

No data available for Pathways by source for FIS1 Gene

Compounds for FIS1 Gene

(1) Novoseek inferred chemical compound relationships for FIS1 Gene

Compound -log(P) Hits PubMed IDs
mdv 1 88 3
genes like me logo Genes that share compounds with FIS1: view

Transcripts for FIS1 Gene

Unigene Clusters for FIS1 Gene

Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FIS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIS1 Gene

No ASD Table

Relevant External Links for FIS1 Gene

GeneLoc Exon Structure for
FIS1
ECgene alternative splicing isoforms for
FIS1

Expression for FIS1 Gene

mRNA expression in normal human tissues for FIS1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FIS1 Gene

SOURCE GeneReport for Unigene cluster for FIS1 Gene Hs.423968

genes like me logo Genes that share expressions with FIS1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FIS1 Gene

Orthologs for FIS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FIS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIS1 35
  • 100 (n)
  • 100 (a)
FIS1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FIS1 35
  • 93.2 (n)
  • 97.37 (a)
FIS1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FIS1 35
  • 92.11 (n)
  • 98.68 (a)
FIS1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fis1 35
  • 89.04 (n)
  • 96.05 (a)
Fis1 16
Fis1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FIS1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fis1 35
  • 89.46 (n)
  • 97.79 (a)
lizard
(Anolis carolinensis)
Reptilia FIS1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fis1 35
  • 72.41 (n)
  • 75.5 (a)
Str.10685 35
zebrafish
(Danio rerio)
Actinopterygii FIS1 36
  • 66 (a)
OneToOne
im:6905231 35
  • 64.43 (n)
  • 69.13 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009852 35
  • 56.37 (n)
  • 51.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fis1 35
  • 53.38 (n)
  • 49.32 (a)
Fis1 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fis-1 36
  • 39 (a)
OneToMany
fis-2 35
  • 48.95 (n)
  • 39.16 (a)
fis-2 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FIS1 36
  • 25 (a)
OneToOne
FIS1 38
Species with no ortholog for FIS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FIS1 Gene

ENSEMBL:
Gene Tree for FIS1 (if available)
TreeFam:
Gene Tree for FIS1 (if available)

Paralogs for FIS1 Gene

Pseudogenes.org Pseudogenes for FIS1 Gene

genes like me logo Genes that share paralogs with FIS1: view

No data available for Paralogs for FIS1 Gene

Variants for FIS1 Gene

Sequence variations from dbSNP and Humsavar for FIS1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2410798 -- 101,245,041(+) TCTAC(C/T)GTGCC utr-variant-5-prime
rs4729673 -- 101,245,456(+) AGAAC(C/G)GGGAG upstream-variant-2KB
rs5886173 -- 101,244,996(+) AGCAC(-/G)GCCTC frameshift-variant, reference
rs6465791 -- 101,244,552(+) TAGTG(C/T)CTACC intron-variant
rs6964812 -- 101,243,569(+) gactc(C/T)gtctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FIS1 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831075 CNV Loss 17160897
esv2422376 CNV Duplication 17116639
esv2752134 CNV Gain 17911159
nsv831076 CNV Loss 17160897
dgv7410n71 CNV Loss 21882294
esv2422326 CNV Duplication 17116639
nsv5875 CNV Insertion 18451855
nsv831077 CNV Loss 17160897

Relevant External Links for FIS1 Gene

HapMap Linkage Disequilibrium report
FIS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIS1 Gene

Disorders for FIS1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for FIS1 Gene including...

Search for FIS1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FIS1 Gene

Relevant External Links for FIS1

Genetic Association Database (GAD)
FIS1
Human Genome Epidemiology (HuGE) Navigator
FIS1
genes like me logo Genes that share disorders with FIS1: view

No data available for UniProtKB/Swiss-Prot for FIS1 Gene

Publications for FIS1 Gene

  1. The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. (PMID: 14623186) Suzuki M. … Tjandra N. (J. Mol. Biol. 2003) 3 4 23
  2. Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology. (PMID: 14996942) Stojanovski D. … Ryan M.T. (J. Cell Sci. 2004) 2 3 4
  3. Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold. (PMID: 14705031) Dohm J.A. … Gittis A.G. (Proteins 2004) 3 4
  4. Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. (PMID: 23283981) LosA^n O.C. … Chan D.C. (Mol. Biol. Cell 2013) 3 4
  5. MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. (PMID: 23921378) Palmer C.S. … Ryan M.T. (J. Biol. Chem. 2013) 3 4

Products for FIS1 Gene

Sources for FIS1 Gene

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