Aliases for FIS1 Gene
External Ids for FIS1 Gene
Previous Symbols for FIS1 Gene
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FIS1 Gene
FIS1 (Fission 1 (Mitochondrial Outer Membrane) Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with FIS1 include spinocerebellar ataxia 12 and dental fluorosis. GO annotations related to this gene include receptor binding.
UniProtKB/Swiss-Prot for FIS1 Gene
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.