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FIS1 Gene

protein-coding   GIFtS: 55
GCID: GC07M100882

Fission 1 (Mitochondrial Outer Membrane) Homolog (S. Cerevisiae)

(Previous names: tetratricopeptide repeat domain 11, fission 1 (mitochondrial...)
(Previous symbol: TTC11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fission 1 (Mitochondrial Outer Membrane) Homolog (S. Cerevisiae)1 2     TPR Repeat Protein 112 3
TTC111 2 3 5     CGI-135 Protein1
Tetratricopeptide Repeat Domain 111 2     Fission 1 (Mitochondrial Outer Membrane) Homolog (Yeast)1
Tetratricopeptide Repeat Protein 112 3     H_NH0132A01.62
FIS1 Homolog2 3     Mitochondrial Fission 1 Protein2
hFis12 3     

External Ids:    HGNC: 216891   Entrez Gene: 510242   Ensembl: ENSG000002142537   OMIM: 6090035   UniProtKB: Q9Y3D63   

Export aliases for FIS1 gene to outside databases

Previous GC identifers: GC07M100477 GC07M100665 GC07M095475


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FIS1 Gene:
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a
mitochondrial complex that promotes mitochondrial fission (James et al., 2003 (PubMed 12783892)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for FIS1 Gene:
FIS1 (fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with FIS1 include dental fluorosis, and spinocerebellar ataxia. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot: FIS1_HUMAN, Q9Y3D6
Function: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor
role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the
mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the
cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission

Gene Wiki entry for FIS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FIS1 gene promoter:
         Max1   Egr-1   NRSF form 1   NRSF form 2   Arnt   YY1   FOXO1a   Pax-4a   c-Myc   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FIS1 promoter sequence
   Search Chromatin IP Primers for FIS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FIS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

FIS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FIS1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100882:  view genomic region     (about GC identifiers)

Start:
100,882,739 bp from pter      End:
100,895,597 bp from pter
Size:
12,859 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 100,241,280-100,246,758     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FIS1_HUMAN, Q9Y3D6 (See protein sequence)
Recommended Name: Mitochondrial fission 1 protein  
Size: 152 amino acids; 16938 Da
Subunit: Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5. Interacts with MIEF1
2 PDB 3D structures from and Proteopedia for FIS1:
1NZN (3D)        1PC2 (3D)    
Secondary accessions: Q9BTP3

Explore the universe of human proteins at neXtProt for FIS1: NX_Q9Y3D6

Explore proteomics data for FIS1 at MOPED

Post-translational modifications: 

  • Ubiquitinated by MARCH51
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FIS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057152.2  
    ENSEMBL proteins: 
     ENSP00000411442   ENSP00000442056   ENSP00000395964   ENSP00000223136   ENSP00000444771  
     ENSP00000413500  

    FIS1 Human Recombinant Protein Products:

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    Novus Biologicals FIS1 Proteins
    Novus Biologicals FIS1 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for FIS1

    FIS1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for FIS1

    FIS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for FIS1
    Cloud-Clone Corp. CLIAs for FIS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR016543 Fis1
     IPR011990 TPR-like_helical
     IPR028058 Fis1_TPR_N
     IPR028061 Fis1_TPR_C

    Graphical View of Domain Structure for InterPro Entry Q9Y3D6

    ProtoNet protein and cluster: Q9Y3D6

    UniProtKB/Swiss-Prot: FIS1_HUMAN, Q9Y3D6
    Domain: The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is
    necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L
    Similarity: Belongs to the FIS1 family
    Similarity: Contains 1 TPR repeat


    FIS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FIS1_HUMAN, Q9Y3D6
    Function: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor
    role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the
    mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the
    cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0005515protein binding IPI12861026
         
    FIS1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FIS1:
     G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fis1):
     no phenotypic analysis 

    FIS1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FIS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FIS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FIS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FIS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target FIS1:
    hsa-mir-505-3p (MIRT041016), hsa-mir-484 (MIRT006714)

    Block miRNA regulation of human, mouse, rat FIS1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FIS1:
    hsa-miR-1266 hsa-miR-186*
    SwitchGear 3'UTR luciferase reporter plasmidFIS1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat FIS1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: FIS1 (NM_016068)
    Sino Biological Human cDNA Clone for FIS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIS1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FIS1_HUMAN, Q9Y3D6: Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    peroxisome5
    cytosol2
    extracellular1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005777peroxisome ISS14561759
    GO:0005779integral component of peroxisomal membrane IDA16107562
    GO:0031307integral component of mitochondrial outer membrane NAS18845145
    GO:0043234protein complex IDA17408615

    FIS1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including FIS1: 
              Mitochondria in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FIS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FIS1 (Q9Y3D61, 2, 3 ENSP000002231364) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCAP31P515721, 2, 3, ENSP000003923304EBI-3385283,EBI-77683 MINT-8143489 MINT-8143644 MINT-8143627 MINT-8143480 MINT-8143498 MINT-8143661 MINT-8143690 MINT-8143706 I2D: score=1 STRING: ENSP00000392330
    DNM1LO004292, 3, ENSP000002664814MINT-8212925 I2D: score=2 STRING: ENSP00000266481
    MIEF1Q9NQG61, 2, 3, ENSP000003271244EBI-3385283,EBI-740987 MINT-8212968 MINT-8293136 MINT-8212925 MINT-8212955 I2D: score=1 STRING: ENSP00000327124
    UBCP0CG482, 3, ENSP000003448184MINT-2844122 I2D: score=2 STRING: ENSP00000344818
    MARCH5Q9NX472, 3, ENSP000003518134MINT-2844143 I2D: score=2 STRING: ENSP00000351813
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000266mitochondrial fission IMP19864424
    GO:0000422mitochondrion degradation IDA18515060
    GO:0001836release of cytochrome c from mitochondria IMP19864424
    GO:0006626protein targeting to mitochondrion IMP18845145
    GO:0007204positive regulation of cytosolic calcium ion concentration IMP--

    FIS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FIS1

    1 Novoseek inferred chemical compound relationship for FIS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mdv 1 88 3 16272155 (2), 14623186 (1)



    FIS1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FIS1 gene: 
    NM_016068.2  

    Unigene Cluster for FIS1:

    Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
    Hs.423968  [show with all ESTs]
    Unigene Representative Sequence: BM013783
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449367 ENST00000482199 ENST00000474120(uc010lhu.3) ENST00000442303
    ENST00000463406 ENST00000223136(uc003uyj.4) ENST00000473527(uc010lht.3)
    ENST00000435848 ENST00000480497
    miRNA
    Products:
         
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    2 qRT-PCR Assays for microRNAs that regulate FIS1:
    hsa-miR-1266 hsa-miR-186*
    SwitchGear 3'UTR luciferase reporter plasmidFIS1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FIS1 (NM_016068)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIS1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FIS1
      QuantiTect SYBR Green Assays in human, mouse, rat FIS1
      QuantiFast Probe-based Assays in human, mouse, rat FIS1

    Additional mRNA sequence: 

    AF151893.1 AK310968.1 AK311665.1 BC003540.1 BC009428.1 

    9 DOTS entries:

    DT.91734186  DT.451632  DT.97843875  DT.100031408  DT.95200450  DT.91698157  DT.100676310  DT.446722 
    DT.120940423 

    Selected AceView cDNA sequences (see all 325):

    BQ695317 AA181312 AA192762 BQ026742 AK124705 BU169378 BE302867 BF507959 
    AI148099 NM_138429 N93442 BM764727 BM784371 R53208 BI828753 CB119317 
    BI836529 AI961636 BE876790 AJ572607 BM832816 BM997988 AA436345 BC009428 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FIS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTTGGGA
    FIS1 Expression
    About this image

    FIS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FIS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.423968
        Pathway & Disease-focused RT2 Profiler PCR Array including FIS1: 
              Mitochondria in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FIS1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fis11 , 5 fission 1 (mitochondrial outer membrane) homolog (yeast)1, 5 89.04(n)1
    96.05(a)1
      5 (76.06 cM)5
    664371  NM_025562.31  NP_079838.11 
     1369532755 
    lizard
    (Anolis carolinensis)
    Reptilia FIS16
    fission 1 (mitochondrial outer membrane) homolog (...
    73(a)
    1 ↔ 1
    GL343220.1(4000-14430)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.106852 Transcribed sequence with moderate similarity to protein more 76.55(n)    BX689976.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054679.12   -- 67.63(n)    BC054679.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fis11 Fis1 53.38(n)
    49.32(a)
      49892  NM_001144135.2  NP_001137607.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fis-21 fis-2 48.95(n)
    39.16(a)
      184409  NM_001029389.5  NP_001024560.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FIS1(YIL065C)4 Protein involved in mitochondrial membrane fission more   --   9(241775-241308) 854745  NP_012199.1 


    ENSEMBL Gene Tree for FIS1 (if available)
    TreeFam Gene Tree for FIS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FIS1 gene

    FIS1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FIS1
    PGOHUM00000237328


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FIS1 (see all 120)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424618181,2
    C--100884186(+) AGCAGC/TTCTGG 2 E syn10--------
    rs1468327921,2
    C--100884210(+) AGAGGA/GTGAGA 1 -- int10--------
    rs1847727211,2
    --100884310(+) TCCTAA/CGCCTC 1 -- int10--------
    rs1868793051,2
    --100884502(+) GGCATC/TTGCTG 1 -- int10--------
    rs731859381,2
    C--100884535(+) TTTCAC/TTCGTC 1 -- int13Minor allele frequency- T:0.30NA EA 242
    rs1406761621,2
    C--100884684(+) TTCAGG/TAGAGA 1 -- int10--------
    rs132403131,2
    C--100884752(+) CTGCCT/CTGGCC 1 -- int11Minor allele frequency- C:0.00NA 2
    rs132275911,2
    C--100884753(+) TGCCCC/TGGCCT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1143170901,2
    --100884803(+) CTGTAC/TAATTA 1 -- int10--------
    rs1900126091,2
    C--100884888(+) TTCCCC/TGAAGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for FIS1 (100882739 - 100895597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for FIS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    esv2422376CNV Duplication17116639
    esv2422326CNV Duplication17116639
    nsv5875CNV Insertion18451855
    nsv831075CNV Loss17160897
    nsv831076CNV Loss17160897
    nsv831077CNV Loss17160897
    dgv7410n71CNV Loss21882294
    esv2752134CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FIS1
    DNA2.0 Custom Variant and Variant Library Synthesis for FIS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609003    OMIM disorders: --

    9 diseases for FIS1:    
    About MalaCards
    dental fluorosis    spinocerebellar ataxia    crohn's disease    ataxia
    alzheimer's disease    malaria    prostate cancer    prostatitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for FIS1:
    Dental fluorosis

    FIS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FIS1
    Human Genome Epidemiology (HuGE) Navigator: FIS1 (1 document)

    Export disorders for FIS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FIS1 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with FIS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology. (PubMed id 14996942)1, 2, 3 Stojanovski D.... Ryan M.T. (J. Cell Sci. 2004)
    2. The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. (PubMed id 14623186)1, 2, 9 Suzuki M.... Tjandra N. (J. Mol. Biol. 2003)
    3. MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. (PubMed id 23921378)1, 2 Palmer C.S....Ryan M.T. (J. Biol. Chem. 2013)
    4. Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. (PubMed id 21701560)1, 2 Zhao J.... Nister M. (EMBO J. 2011)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. (PubMed id 16874301)1, 2 Yonashiro R....Yanagi S. (EMBO J. 2006)
    7. Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1. (PubMed id 16010987)1, 3 Kong D....Kuo T.H. (Mol. Cell. Biochem. 2005)
    8. Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1. (PubMed id 16118244)1, 2 Yu T.... Yoon Y. (J. Cell Sci. 2005)
    9. A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. (PubMed id 16107562)1, 2 Koch A.... Schrader M. (Mol. Biol. Cell 2005)
    10. Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold. (PubMed id 14705031)1, 2 Dohm J.A.... Gittis A.G. (Proteins 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
    PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51024 HGNC: 21689 AceView: CLDN15andTTC11 Ensembl:ENSG00000214253 euGenes: HUgn51024
    ECgene: FIS1 H-InvDB: FIS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FIS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FIS1 gene:
    Search GeneIP for patents involving FIS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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