Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FIP1L1 Gene

protein-coding   GIFtS: 55
GCID: GC04P054159

Factor Interacting With PAPOLA And CPSF1

(Previous names: FIP1 like 1 (S. cerevisiae), FIP1L1 cleavage and polyadenylation...)
  See FIP1L1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Factor Interacting With PAPOLA And CPSF11 2     FIP1 Like 1 (S. Cerevisiae)1
FIP1L1 Cleavage And Polyadenylation Specific Factor Subunit1 2     Rhe2
Factor Interacting With PAP2 3     FIP1 Like 12
Rearranged In Hypereosinophilia2 3     Pre-MRNA 3'-End-Processing Factor FIP12
FIP12 3     RHE3
FIP1-Like 1 Protein2 3     EC 1.1.1.868
hFip12 3     EC 4.2.1.338

External Ids:    HGNC: 191241   Entrez Gene: 816082   Ensembl: ENSG000001452167   OMIM: 6076865   UniProtKB: Q6UN153   

Export aliases for FIP1L1 gene to outside databases

Previous GC identifers: GC04P054224 GC04P054093 GC04P054084 GC04P053938 GC04P050188


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FIP1L1 Gene:
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that
polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP),
binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a
PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates
an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The
FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids
of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some
forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic
eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing
results in multiple transcript variants encoding distinct isoforms. (provided by RefSeq, Oct 2008)

GeneCards Summary for FIP1L1 Gene:
FIP1L1 (factor interacting with PAPOLA and CPSF1) is a protein-coding gene. Diseases associated with FIP1L1 include mast-cell sarcoma, and hypereosinophilic syndrome. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: FIP1_HUMAN, Q6UN15
Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in
pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and
other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and
stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to
tether poly(A) polymerase to the CPSF complex

Gene Wiki entry for FIP1L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_022853.16  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FIP1L1 gene promoter:
         AML1a   AP-1   MZF-1   AREB6   MEF-2A   POU2F1   POU2F1a   aMEF-2   TGIF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFIP1L1 promoter sequence
   Search Chromatin IP Primers for FIP1L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FIP1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

FIP1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FIP1L1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P054159:  view genomic region     (about GC identifiers)

Start:
54,243,810 bp from pter      End:
55,161,439 bp from pter
Size:
917,630 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FIP1_HUMAN, Q6UN15 (See protein sequence)
Recommended Name: Pre-mRNA 3'-end-processing factor FIP1  
Size: 594 amino acids; 66526 Da
Subunit: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1,
CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with CPSF1, CPSF4,
CSTF2, CSTF3 and PAPOLA
Sequence caution: Sequence=AAH24016.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH52959.1;
Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: B4DIR3 G3XAD6 Q0VGE0 Q499Y4 Q49AU3 Q7Z608 Q8WVN3 Q96F80 Q9H077
Alternative splicing: 4 isoforms:  Q6UN15-1   Q6UN15-3   Q6UN15-4   Q6UN15-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FIP1L1: NX_Q6UN15

Explore proteomics data for FIP1L1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for FIP1L1 (Q6UN15)
     VAFPHLP  EIQDGRF 


    See FIP1L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001128409.1  NP_001128410.1  NP_112179.2  

    ENSEMBL proteins: 
     ENSP00000336752   ENSP00000351383   ENSP00000425456   ENSP00000302993   ENSP00000423325  
     ENSP00000421241   ENSP00000421691  

    FIP1L1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FIP1L1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FIP1L1
    GenScript Custom Purified and Recombinant Proteins Services for FIP1L1
    Novus Biologicals FIP1L1 Protein
    Novus Biologicals FIP1L1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FIP1L1

     
    Search eBioscience for Proteins for FIP1L1 

     
    antibodies-online proteins for FIP1L1 (3 products) 

     
    antibodies-online peptides for FIP1L1

    FIP1L1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FIP1L1
    Novus Biologicals FIP1L1 Antibodies
    Abcam antibodies for FIP1L1
    Cloud-Clone Corp. Antibodies for FIP1L1
    Search ThermoFisher Antibodies for FIP1L1
    LSBio Antibodies in human, mouse, rat for FIP1L1
    antibodies-online antibodies for FIP1L1 (21 products) 

    FIP1L1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FIP1L1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FIP1L1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FIP1L1
    Cloud-Clone Corp. CLIAs for FIP1L1
    Search eBioscience for ELISAs for FIP1L1 
    antibodies-online kits for FIP1L1 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR007854 Fip1

    Graphical View of Domain Structure for InterPro Entry Q6UN15

    ProtoNet protein and cluster: Q6UN15

    UniProtKB/Swiss-Prot: FIP1_HUMAN, Q6UN15
    Similarity: Belongs to the FIP1 family


    Find genes that share domains with FIP1L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FIP1_HUMAN, Q6UN15
    Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in
    pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and
    other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and
    stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to
    tether poly(A) polymerase to the CPSF complex

         Enzyme Numbers (IUBMB): EC 4.2.1.332 EC 1.1.1.862

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FIP1L1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FIP1L1:
     Decreased viability  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FIP1L1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FIP1L1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FIP1L1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FIP1L1

    miRNA
    Products:
        
    miRTarBase miRNAs that target FIP1L1:
    hsa-mir-877-3p (MIRT036936), hsa-mir-155-5p (MIRT020609)

    Block miRNA regulation of human, mouse, rat FIP1L1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate FIP1L1:
    hsa-miR-142-5p hsa-miR-513a-3p hsa-miR-589* hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidFIP1L1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FIP1L1
    Predesigned siRNA for gene silencing in human, mouse, rat FIP1L1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FIP1L1

    Clone
    Products:
         
    OriGene clones in human, mouse for FIP1L1 (see all 22)
    OriGene ORF clones in mouse, rat for FIP1L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FIP1L1 (NM_001134938)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIP1L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIP1L1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FIP1L1
    Browse ESI BIO Cell Lines and PureStem Progenitors for FIP1L1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIP1L1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FIP1_HUMAN, Q6UN15: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005847mRNA cleavage and polyadenylation specificity factor complex IEA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with FIP1L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FIP1L1 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with FIP1L1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for FIP1L1):
        mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FIP1L1
    Interactions:

        GeneGlobe Interaction Network for FIP1L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FIP1L1 (Q6UN152, 3 ENSP000003367524) via UniProtKB, MINT, STRING, and/or I2D (see all 657)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF4O956392, 3, ENSP000002924764MINT-7945693 MINT-67825 I2D: score=5 STRING: ENSP00000292476
    SRRM2Q9UQ352, 3, ENSP000003017404MINT-7945693 I2D: score=1 STRING: ENSP00000301740
    WWOXQ9NZC72, 3, ENSP000003861614MINT-72774 I2D: score=3 STRING: ENSP00000386161
    GSK3BP498413, ENSP000003248064I2D: score=1 STRING: ENSP00000324806
    WDR33Q9C0J82, ENSP000003253774MINT-7945693 STRING: ENSP00000325377
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----

    Find genes that share ontologies with FIP1L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FIP1L1 (FIP1)

    2 Novoseek inferred chemical compound relationships for FIP1L1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    imatinib 81.6 3 15175999 (1), 12660384 (1)
    tyrosine 50.7 4 17634706 (1), 15070659 (1), 17666373 (1), 15772698 (1)

    1 PharmGKB related drug/compound annotation for FIP1L1 gene    About this table
    Drug/compound PharmGKB Annotation
    imatinib



    Find genes that share compounds with FIP1L1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FIP1L1 gene (3 alternative transcripts): 
    NM_001134937.1  NM_001134938.1  NM_030917.3  

    Unigene Cluster for FIP1L1:

    FIP1 like 1 (S. cerevisiae)
    Hs.624245  [show with all ESTs]
    Unigene Representative Sequence: BC024016
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511376 ENST00000337488(uc003gzy.3) ENST00000358575(uc011bzu.2 uc003gzz.3)
    ENST00000507922(uc003gzx.4) ENST00000306932 ENST00000505125(uc003hab.3)
    ENST00000507166 ENST00000513975(uc011bzt.1) ENST00000510668 ENST00000514543
    ENST00000513008 ENST00000504094(uc010ign.3 uc003hae.3) ENST00000511055
    ENST00000507206
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FIP1L1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate FIP1L1:
    hsa-miR-142-5p hsa-miR-513a-3p hsa-miR-589* hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidFIP1L1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FIP1L1
    Predesigned siRNA for gene silencing in human, mouse, rat FIP1L1
    Clone
    Products:
         
    OriGene clones in human, mouse for FIP1L1 (see all 22)
    OriGene ORF clones in mouse, rat for FIP1L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FIP1L1 (NM_001134938)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIP1L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIP1L1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FIP1L1
    OriGene qSTAR qPCR primer pairs in human, mouse for FIP1L1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FIP1L1
      QuantiTect SYBR Green Assays in human, mouse, rat FIP1L1
      QuantiFast Probe-based Assays in human, mouse, rat FIP1L1

    Additional mRNA sequence: 

    AF161429.1 AK090938.1 AK123992.1 AK295737.1 AK308145.1 AL136910.1 AY366510.1 BC011543.1 
    BC017724.1 BC024016.1 BC026724.1 BC052959.1 BC110383.1 

    23 DOTS entries:

    DT.100036591  DT.95225430  DT.100815951  DT.411959  DT.100808531  DT.95225468  DT.95225432  DT.97859095 
    DT.100776039  DT.121243782  DT.87016469  DT.100802830  DT.92450488  DT.100815950  DT.101984080  DT.121243770 
    DT.91690882  DT.100815949  DT.121243816  DT.100770792  DT.121243833  DT.75159342  DT.92450497 

    Selected AceView cDNA sequences (see all 310):

    AA463605 AI126030 BQ102337 BQ575501 CR593836 CD673738 BF718630 BQ229276 
    AW469643 AA150709 BC024016 CK822976 R79584 AI858647 AI141498 BX115080 
    BX358104 BC026724 CB120949 AL699960 AI250229 AI589053 BE902088 AI581043 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FIP1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FIP1L1 Expression
    About this image


    FIP1L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    FIP1L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FIP1L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.624245
        Custom PCR Arrays for FIP1L1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FIP1L1
    OriGene qSTAR qPCR primer pairs in human, mouse for FIP1L1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FIP1L1
    QuantiTect SYBR Green Assays in human, mouse, rat FIP1L1
    QuantiFast Probe-based Assays in human, mouse, rat FIP1L1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIP1L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FIP1L1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fip1l15 FIP1 like 1 (S. cerevisiae)   --   5 (39.51 cM) 74535449 
    chicken
    (Gallus gallus)
    Aves FIP1L16
    factor interacting with PAPOLA and CPSF1
    80(a)
    1 ↔ 1
    4(65345818-65366325)
    lizard
    (Anolis carolinensis)
    Reptilia FIP1L16
    factor interacting with PAPOLA and CPSF1
    80(a)
    1 ↔ 1
    5(103463737-103514447)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.44392 Xenopus laevis transcribed sequence with moderate similarity more 77.65(n)    BX845735.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd36f112 wufd36f11 76.39(n)   325873  BI884704.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fip16
    --
    22(a)
    1 ↔ 1
    3R(310763-313185)
    worm
    (Caenorhabditis elegans)
    Secernentea fipp-16
    Protein FIPP-1 (fipp-1) mRNA, complete cds
    29(a)
    1 ↔ 1
    V(4371807-4373811) WBGene00017988
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FIP1(YJR093C)4 Subunit of cleavage polyadenylation factor (CPF), interacts more   --   10(604203-603220) 853555  NP_012626.1 


    ENSEMBL Gene Tree for FIP1L1 (if available)
    TreeFam Gene Tree for FIP1L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FIP1L1 (see all 1698)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349385801,2
    C--50187938(+) CTAGA-/CAAA  
      CCTAGA
    GCTCC
    3 -- us2k10--------
    rs106081711,2
    C--50191499(+) GTACG-/TGAAT 
            
    ATTCA
    3 -- int12Minor allele frequency- TGAAT:0.25NA CSA 4
    rs3746090571,2
    C--50208226(+) TTTTTT/-AACAA 3 -- int11Minor allele frequency- -:0.00NA 2
    rs1457184651,2
    C--50209940(+) TATTT-/TAAGTG 3 -- int10--------
    rs711970161,2
    C--50215327(+) TTTTT-/T/TT  
            
    ATTAT
    3 -- int11NA 2
    rs342915851,2
    C--50222277(+) AAGGT-/GGGGGG 3 -- int11Minor allele frequency- G:0.00CSA 2
    rs800078021,2
    C--50222281(+) TGGGGA/GGGGCT 3 -- int10--------
    rs716622231,2
    C--50226833(+) TTTTTTT/-GCTTT 3 -- int11Minor allele frequency- -:0.50NA 2
    rs286336461,2
    C--50228966(+) AAAAAG/AAAAAG 3 -- int1 trp32Minor allele frequency- A:0.33WA CSA 3
    rs58582111,2
    C--50247356(+) AAGCGT/-TAGTT 3 -- int12Minor allele frequency- -:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for FIP1L1 (54243810 - 54493810 bp, first 250kb of FIP1L1)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FIP1L1: --
    Human Gene Mutation Database (HGMD): FIP1L1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FIP1L1
    DNA2.0 Custom Variant and Variant Library Synthesis for FIP1L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607686    OMIM disorders: --

    UniProtKB/Swiss-Prot: FIP1_HUMAN, Q6UN15
  • Note=A chromosomal aberration involving FIP1L1 is found in some cases of hypereosinophilic syndrome.
    Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA)

  • 5 diseases for FIP1L1:    
    About MalaCards
    mast-cell sarcoma    hypereosinophilic syndrome    hypereosinophilic syndrome, idiopathic, resistant to imatinib    endomyocardial fibrosis
    acute promyelocytic leukemia

    7 diseases from the University of Copenhagen DISEASES database for FIP1L1:
    Eosinophilia     Mastocytosis     Leukemia     Endomyocardial fibrosis
    Myelofibrosis     mast-cell sarcoma     Polycythemia vera

    Find genes that share disorders with FIP1L1           About GenesLikeMe

    3 Novoseek inferred disease relationships for FIP1L1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypereosinophilic syndrome 92 4 17634706 (1), 17666373 (1), 15951264 (1), 16768284 (1)
    idiopathic hypereosinophilic syndrome 90.8 2 15772698 (1), 12660384 (1)
    eosinophilia 73.2 1 12676775 (1)

    Genetic Association Database (GAD): FIP1L1

    Export disorders for FIP1L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FIP1L1 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with FIP1L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PubMed id 14749727)1, 2, 3, 9 Kaufmann I.... Keller W. (EMBO J. 2004)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    3. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. (PubMed id 12660384)1, 2, 9 Cools J.... Gilliland D.G. (N. Engl. J. Med. 2003)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. A 57-nucleotide upstream early polyadenylation element in human papillomavirus type 16 interacts with hFip1, CstF-64, hnRNP C1/C2, and polypyrimidine tract binding protein. (PubMed id 15767428)1, 2 Zhao X.... Schwartz S. (J. Virol. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. (PubMed id 12808148)1, 2 Griffin J.H.... Briesewitz R. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    9. The FIP1L1-PDGFRA fusion gene and the KIT D816V mutation are coexisting in a small subset of myeloid/lymphoid neoplasms with eosinophilia. (PubMed id 24458279)1 Schmitt-Graeff A.H....Reiter A. (Blood 2014)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 81608 HGNC: 19124 AceView: FIP1L1 Ensembl:ENSG00000145216 euGenes: HUgn81608
    ECgene: FIP1L1 Kegg: 81608 H-InvDB: FIP1L1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FIP1L1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FIP1L1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FIP1L1 gene:
    Search GeneIP for patents involving FIP1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FIP1L1  
     OriGene qPCR primer pairs and template standards for FIP1L1   OriGene Protein Over-expression Lysate for FIP1L1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FIP1L1  
     OriGene qSTAR qPCR primer pairs in human, mouse for FIP1L1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FIP1L1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FIP1L1   OriGene Custom Protein Services for FIP1L1  

     
     
     Block miRNA regulation of human, mouse, rat FIP1L1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FIP1L1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FIP1L1 Predesigned siRNA for gene silencing in human, mouse, rat FIP1L1
     QuantiFast Probe-based Assays in human, mouse, rat FIP1L1 QuantiTect SYBR Green Assays in human, mouse, rat FIP1L1
     Custom PCR Arrays for FIP1L1 Search Chromatin IP Primers for FIP1L1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FIP1L1  GeneGlobe Interaction Network for FIP1L1
     Regulatory tfbs in FIP1L1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FIP1L1 GenScript cDNA clones with any tag delivered in your preferred vector for FIP1L1
     GenScript Custom Assay Services for FIP1L1 GenScript Custom overexpressing Cell Line Services for FIP1L1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FIP1L1 (FIP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FIP1L1 antibodies
     FIP1L1 proteins
     FIP1L1 lysates
     Antibodies for FIP1L1
     See all of Abcam's Antibodies, Kits and Proteins for FIP1L1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FIP1L1
     Antibodies for FIP1L1
     ELISAs for FIP1L1
     CLIAs for FIP1L1



     Browse ESI BIO Cell Lines and PureStem Progenitors for FIP1L1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIP1L1
     SwitchGear 3'UTR luciferase reporter plasmids for FIP1L1
     SwitchGear Promoter luciferase reporter plasmids for FIP1L1
     Search ThermoFisher Antibodies for FIP1L1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIP1L1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FIP1L1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FIP1L1
     LSBio Antibodies in human, mouse, rat for FIP1L1
     Browse compounds at ApexBio
     Search Addgene for plasmids for FIP1L1
      Search eBioscience for proteins for FIP1L1
      Search eBioscience for elisas for FIP1L1
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for FIP1L1 (21 products)
     antibodies-online kits for FIP1L1 (3 products)
     antibodies-online peptides for FIP1L1
     antibodies-online proteins for FIP1L1 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FIP1L1 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4