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Aliases for FILIP1L Gene

Aliases for FILIP1L Gene

  • Filamin A Interacting Protein 1-Like 2 3 5
  • Protein Down-Regulated In Ovarian Cancer 1 3 4
  • 130 KDa GPBP-Interacting Protein 3 4
  • 90 KDa GPBP-Interacting Protein 3 4
  • Doc-1 3 4
  • GIP90 3 4
  • DOC1 3 4
  • GPBP-Interacting Protein Of 130 KDa 2
  • Downregulated In Ovarian Cancer 1 2
  • COL4A3BPIP 4
  • GIP130 3

External Ids for FILIP1L Gene

Previous GeneCards Identifiers for FILIP1L Gene

  • GC03M101035
  • GC03M099548
  • GC03M096920

Summaries for FILIP1L Gene

GeneCards Summary for FILIP1L Gene

FILIP1L (Filamin A Interacting Protein 1-Like) is a Protein Coding gene. Diseases associated with FILIP1L include Ovarian Cancer. An important paralog of this gene is CTTNBP2.

UniProtKB/Swiss-Prot for FILIP1L Gene

  • Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FILIP1L Gene

Genomics for FILIP1L Gene

Regulatory Elements for FILIP1L Gene

Enhancers for FILIP1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FILIP1L on UCSC Golden Path with GeneCards custom track

Genomic Location for FILIP1L Gene

99,830,141 bp from pter
100,114,513 bp from pter
284,373 bases
Minus strand

Genomic View for FILIP1L Gene

Genes around FILIP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FILIP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FILIP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FILIP1L Gene

Proteins for FILIP1L Gene

  • Protein details for FILIP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Filamin A-interacting protein 1-like
    Protein Accession:
    Secondary Accessions:
    • B2CNV7
    • B2CNV8
    • Q13597
    • Q2YDY5
    • Q6KFX5
    • Q6KFX6
    • Q6KFX7
    • Q8IUM3
    • Q8N6Z0

    Protein attributes for FILIP1L Gene

    1135 amino acids
    Molecular mass:
    130382 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA98972.1; Type=Frameshift; Positions=1000; Evidence={ECO:0000305}; Sequence=AAN16206.1; Type=Frameshift; Positions=747; Evidence={ECO:0000305}; Sequence=ACB37436.1; Type=Frameshift; Positions=750; Evidence={ECO:0000305};

    Alternative splice isoforms for FILIP1L Gene

neXtProt entry for FILIP1L Gene

Proteomics data for FILIP1L Gene at MOPED

Post-translational modifications for FILIP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FILIP1L Gene

Domains & Families for FILIP1L Gene

Protein Domains for FILIP1L Gene


Suggested Antigen Peptide Sequences for FILIP1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FILIP1 family.
  • Belongs to the FILIP1 family.
genes like me logo Genes that share domains with FILIP1L: view

No data available for Gene Families for FILIP1L Gene

Function for FILIP1L Gene

Molecular function for FILIP1L Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
UniProtKB/Swiss-Prot Induction:
Up-regulated in endothelial cells with the angiogenesis inhibitors endostatin and fumagillin. By endothelial monocyte-activating polypeptide II in endothelial cells.

Phenotypes for FILIP1L Gene

GenomeRNAi human phenotypes for FILIP1L:
genes like me logo Genes that share phenotypes with FILIP1L: view

Animal Model Products

CRISPR Products

miRNA for FILIP1L Gene

miRTarBase miRNAs that target FILIP1L

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FILIP1L Gene

Localization for FILIP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for FILIP1L Gene

Cytoplasm. Membrane. Nucleus.

Subcellular locations from

Jensen Localization Image for FILIP1L Gene COMPARTMENTS Subcellular localization image for FILIP1L gene
Compartment Confidence
nucleus 5
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for FILIP1L Gene

Pathways & Interactions for FILIP1L Gene

SuperPathways for FILIP1L Gene

No Data Available

Interacting Proteins for FILIP1L Gene

Selected Interacting proteins: Q4L180-FIL1L_HUMAN for FILIP1L Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FILIP1L Gene


No data available for Pathways by source and SIGNOR curated interactions for FILIP1L Gene

Drugs & Compounds for FILIP1L Gene

No Compound Related Data Available

Transcripts for FILIP1L Gene

Unigene Clusters for FILIP1L Gene

Filamin A interacting protein 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FILIP1L Gene

No ASD Table

Relevant External Links for FILIP1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FILIP1L Gene

mRNA expression in normal human tissues for FILIP1L Gene

mRNA differential expression in normal tissues according to GTEx for FILIP1L Gene

This gene is overexpressed in Artery - Aorta (x7.8) and Artery - Tibial (x5.3).

Protein differential expression in normal tissues from HIPED for FILIP1L Gene

This gene is overexpressed in Uterus (11.9), Plasma (10.7), Gallbladder (10.4), and Colon (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FILIP1L Gene

SOURCE GeneReport for Unigene cluster for FILIP1L Gene Hs.104672

mRNA Expression by UniProt/SwissProt for FILIP1L Gene

Tissue specificity: Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer.
genes like me logo Genes that share expression patterns with FILIP1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for FILIP1L Gene

Orthologs for FILIP1L Gene

This gene was present in the common ancestor of animals.

Orthologs for FILIP1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FILIP1L 35
  • 91.92 (n)
  • 93.19 (a)
  • 94 (a)
(Canis familiaris)
Mammalia FILIP1L 35
  • 92.02 (n)
  • 92.73 (a)
  • 93 (a)
(Mus musculus)
Mammalia Filip1l 35
  • 88.44 (n)
  • 88.76 (a)
Filip1l 16
Filip1l 36
  • 88 (a)
(Pan troglodytes)
Mammalia FILIP1L 35
  • 99.67 (n)
  • 99.56 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Filip1l 35
  • 87.53 (n)
  • 87.77 (a)
(Monodelphis domestica)
Mammalia FILIP1L 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia FILIP1L 36
  • 77 (a)
(Gallus gallus)
Aves FILIP1L 35
  • 73.27 (n)
  • 73.96 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia FILIP1L 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia filip1l 35
  • 69.13 (n)
  • 68.95 (a)
(Danio rerio)
Actinopterygii zgc:158292 35
  • 61.73 (n)
  • 60.07 (a)
FILIP1L (1 of 2) 36
  • 60 (a)
FILIP1L (2 of 2) 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10915 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea C49H3.6 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for FILIP1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FILIP1L Gene

Gene Tree for FILIP1L (if available)
Gene Tree for FILIP1L (if available)

Paralogs for FILIP1L Gene

Paralogs for FILIP1L Gene

(3) SIMAP similar genes for FILIP1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FILIP1L: view

Variants for FILIP1L Gene

Sequence variations from dbSNP and Humsavar for FILIP1L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_050993 -
VAR_050994 -

Structural Variations from Database of Genomic Variants (DGV) for FILIP1L Gene

Variant ID Type Subtype PubMed ID
nsv3918 CNV Insertion 18451855
nsv822194 CNV Loss 20364138
esv2663491 CNV Deletion 23128226
esv2725686 CNV Deletion 23290073
esv2332259 CNV Deletion 18987734
esv2725687 CNV Deletion 23290073
esv988265 CNV Deletion 20482838
esv2945 CNV Deletion 18987735
esv2725688 CNV Deletion 23290073
esv987776 CNV Deletion 20482838
esv2668597 CNV Deletion 23128226
esv26006 CNV Loss 19812545
esv998785 CNV Loss 20482838
dgv818n67 CNV Loss 20364138
esv2507771 CNV Insertion 19546169
esv1177720 CNV Insertion 17803354
esv1440096 CNV Insertion 17803354
nsv822197 CNV Loss 20364138
esv2670786 CNV Deletion 23128226
esv2725689 CNV Deletion 23290073
nsv3919 CNV Insertion 18451855
esv2671411 CNV Deletion 23128226
esv4340 CNV Deletion 18987735
esv2725690 CNV Deletion 23290073
esv2661948 CNV Deletion 23128226

Variation tolerance for FILIP1L Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.40; 85.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FILIP1L Gene

Disorders for FILIP1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for FILIP1L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FILIP1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FILIP1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FILIP1L Gene

Publications for FILIP1L Gene

  1. Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells. (PMID: 15935955) Tandle A.T. … Libutti S.K. (Cytokine 2005) 2 3 4 23 67
  2. Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130). (PMID: 21832087) Revert-Ros F. … Saus J. (J. Biol. Chem. 2011) 2 3
  3. Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. (PMID: 8314147) Mok S.C. … Berkowitz R.S. (Gynecol. Oncol. 1994) 2 3
  4. CpG island hypermethylation frequently silences FILIP1L isoform 2 expression in prostate cancer. (PMID: 23174249) Desotelle J. … Jarrard D. (J. Urol. 2013) 3
  5. Seven new loci associated with age-related macular degeneration. (PMID: 23455636) Fritsche L.G. … Abecasis G.R. (Nat. Genet. 2013) 3

Products for FILIP1L Gene

Sources for FILIP1L Gene