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Aliases for FILIP1L Gene

Aliases for FILIP1L Gene

  • Filamin A Interacting Protein 1 Like 2 3 5
  • Protein Down-Regulated In Ovarian Cancer 1 3 4
  • 130 KDa GPBP-Interacting Protein 3 4
  • 90 KDa GPBP-Interacting Protein 3 4
  • Doc-1 3 4
  • GIP90 3 4
  • DOC1 3 4
  • Filamin A-Interacting Protein 1-Like 3
  • GPBP-Interacting Protein Of 130 KDa 2
  • Downregulated In Ovarian Cancer 1 2
  • COL4A3BPIP 4
  • GIP130 3

External Ids for FILIP1L Gene

Previous GeneCards Identifiers for FILIP1L Gene

  • GC03M101035
  • GC03M099548
  • GC03M096920

Summaries for FILIP1L Gene

GeneCards Summary for FILIP1L Gene

FILIP1L (Filamin A Interacting Protein 1 Like) is a Protein Coding gene. Diseases associated with FILIP1L include Ovarian Cancer. An important paralog of this gene is FILIP1.

UniProtKB/Swiss-Prot for FILIP1L Gene

  • Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FILIP1L Gene

Genomics for FILIP1L Gene

Regulatory Elements for FILIP1L Gene

Enhancers for FILIP1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FILIP1L on UCSC Golden Path with GeneCards custom track

Genomic Location for FILIP1L Gene

Chromosome:
3
Start:
99,830,141 bp from pter
End:
100,114,513 bp from pter
Size:
284,373 bases
Orientation:
Minus strand

Genomic View for FILIP1L Gene

Genes around FILIP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FILIP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FILIP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FILIP1L Gene

Proteins for FILIP1L Gene

  • Protein details for FILIP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4L180-FIL1L_HUMAN
    Recommended name:
    Filamin A-interacting protein 1-like
    Protein Accession:
    Q4L180
    Secondary Accessions:
    • B2CNV7
    • B2CNV8
    • Q13597
    • Q2YDY5
    • Q6KFX5
    • Q6KFX6
    • Q6KFX7
    • Q8IUM3
    • Q8N6Z0

    Protein attributes for FILIP1L Gene

    Size:
    1135 amino acids
    Molecular mass:
    130382 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA98972.1; Type=Frameshift; Positions=1000; Evidence={ECO:0000305}; Sequence=AAN16206.1; Type=Frameshift; Positions=747; Evidence={ECO:0000305}; Sequence=ACB37436.1; Type=Frameshift; Positions=750; Evidence={ECO:0000305};

    Alternative splice isoforms for FILIP1L Gene

neXtProt entry for FILIP1L Gene

Post-translational modifications for FILIP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FILIP1L Gene

Domains & Families for FILIP1L Gene

Protein Domains for FILIP1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FILIP1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4L180

UniProtKB/Swiss-Prot:

FIL1L_HUMAN :
  • Belongs to the FILIP1 family.
Family:
  • Belongs to the FILIP1 family.
genes like me logo Genes that share domains with FILIP1L: view

No data available for Gene Families for FILIP1L Gene

Function for FILIP1L Gene

Molecular function for FILIP1L Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
UniProtKB/Swiss-Prot Induction:
Up-regulated in endothelial cells with the angiogenesis inhibitors endostatin and fumagillin. By endothelial monocyte-activating polypeptide II in endothelial cells.

Gene Ontology (GO) - Molecular Function for FILIP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FILIP1L: view

Phenotypes for FILIP1L Gene

GenomeRNAi human phenotypes for FILIP1L:
genes like me logo Genes that share phenotypes with FILIP1L: view

Animal Model Products

CRISPR Products

miRNA for FILIP1L Gene

miRTarBase miRNAs that target FILIP1L

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FILIP1L Gene

Localization for FILIP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for FILIP1L Gene

Cytoplasm. Membrane. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FILIP1L Gene COMPARTMENTS Subcellular localization image for FILIP1L gene
Compartment Confidence
nucleus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for FILIP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FILIP1L: view

Pathways & Interactions for FILIP1L Gene

SuperPathways for FILIP1L Gene

No Data Available

Interacting Proteins for FILIP1L Gene

Gene Ontology (GO) - Biological Process for FILIP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FILIP1L: view

No data available for Pathways by source and SIGNOR curated interactions for FILIP1L Gene

Drugs & Compounds for FILIP1L Gene

No Compound Related Data Available

Transcripts for FILIP1L Gene

Unigene Clusters for FILIP1L Gene

Filamin A interacting protein 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FILIP1L Gene

No ASD Table

Relevant External Links for FILIP1L Gene

GeneLoc Exon Structure for
FILIP1L
ECgene alternative splicing isoforms for
FILIP1L

Expression for FILIP1L Gene

mRNA expression in normal human tissues for FILIP1L Gene

mRNA differential expression in normal tissues according to GTEx for FILIP1L Gene

This gene is overexpressed in Artery - Aorta (x7.8) and Artery - Tibial (x5.3).

Protein differential expression in normal tissues from HIPED for FILIP1L Gene

This gene is overexpressed in Uterus (11.9), Plasma (10.7), Gallbladder (10.4), and Colon (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FILIP1L Gene



NURSA nuclear receptor signaling pathways regulating expression of FILIP1L Gene:

FILIP1L

SOURCE GeneReport for Unigene cluster for FILIP1L Gene:

Hs.104672

mRNA Expression by UniProt/SwissProt for FILIP1L Gene:

Q4L180-FIL1L_HUMAN
Tissue specificity: Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer.
genes like me logo Genes that share expression patterns with FILIP1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for FILIP1L Gene

Orthologs for FILIP1L Gene

This gene was present in the common ancestor of animals.

Orthologs for FILIP1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FILIP1L 34
  • 91.92 (n)
  • 93.19 (a)
FILIP1L 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FILIP1L 34
  • 92.02 (n)
  • 92.73 (a)
FILIP1L 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Filip1l 34
  • 88.44 (n)
  • 88.76 (a)
Filip1l 16
Filip1l 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FILIP1L 34
  • 99.67 (n)
  • 99.56 (a)
FILIP1L 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Filip1l 34
  • 87.53 (n)
  • 87.77 (a)
oppossum
(Monodelphis domestica)
Mammalia FILIP1L 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FILIP1L 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves FILIP1L 34
  • 73.27 (n)
  • 73.96 (a)
FILIP1L 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FILIP1L 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia filip1l 34
  • 69.13 (n)
  • 68.95 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:158292 34
  • 61.73 (n)
  • 60.07 (a)
FILIP1L (1 of 2) 35
  • 60 (a)
OneToMany
FILIP1L (2 of 2) 35
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10915 35
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C49H3.6 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for FILIP1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FILIP1L Gene

ENSEMBL:
Gene Tree for FILIP1L (if available)
TreeFam:
Gene Tree for FILIP1L (if available)

Paralogs for FILIP1L Gene

Paralogs for FILIP1L Gene

(3) SIMAP similar genes for FILIP1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FILIP1L: view

Variants for FILIP1L Gene

Sequence variations from dbSNP and Humsavar for FILIP1L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_050993 -
VAR_050994 -

Structural Variations from Database of Genomic Variants (DGV) for FILIP1L Gene

Variant ID Type Subtype PubMed ID
dgv4829n100 CNV loss 25217958
dgv818n67 CNV loss 20364138
dgv8475n54 CNV gain+loss 21841781
dgv916e214 CNV loss 21293372
esv1177720 CNV insertion 17803354
esv1440096 CNV insertion 17803354
esv2332259 CNV deletion 18987734
esv2507771 CNV insertion 19546169
esv26006 CNV loss 19812545
esv2661948 CNV deletion 23128226
esv2663491 CNV deletion 23128226
esv2668597 CNV deletion 23128226
esv2670786 CNV deletion 23128226
esv2671411 CNV deletion 23128226
esv2725686 CNV deletion 23290073
esv2725687 CNV deletion 23290073
esv2725688 CNV deletion 23290073
esv2725689 CNV deletion 23290073
esv2725690 CNV deletion 23290073
esv2835236 CNV deletion 24192839
esv2835347 CNV deletion 24192839
esv2945 CNV loss 18987735
esv3325883 CNV duplication 20981092
esv3433874 CNV insertion 20981092
esv3562278 CNV deletion 23714750
esv3562279 CNV deletion 23714750
esv3597160 CNV loss 21293372
esv3597161 CNV loss 21293372
esv3597163 CNV loss 21293372
esv3597164 CNV loss 21293372
esv4340 CNV loss 18987735
esv987776 CNV deletion 20482838
esv988265 CNV deletion 20482838
esv998785 CNV loss 20482838
nsv1109534 CNV deletion 24896259
nsv1117011 CNV deletion 24896259
nsv3918 CNV insertion 18451855
nsv3919 CNV insertion 18451855
nsv475174 CNV novel sequence insertion 20440878
nsv591147 CNV loss 21841781
nsv591148 CNV loss 21841781
nsv822194 CNV loss 20364138
nsv822197 CNV loss 20364138
nsv954339 CNV deletion 24416366
nsv954357 CNV deletion 24416366
nsv999332 CNV loss 25217958

Variation tolerance for FILIP1L Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.40; 85.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FILIP1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FILIP1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FILIP1L Gene

Disorders for FILIP1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for FILIP1L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FILIP1L

Genetic Association Database (GAD)
FILIP1L
Human Genome Epidemiology (HuGE) Navigator
FILIP1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FILIP1L
genes like me logo Genes that share disorders with FILIP1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FILIP1L Gene

Publications for FILIP1L Gene

  1. Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells. (PMID: 15935955) Tandle A.T. … Libutti S.K. (Cytokine 2005) 2 3 4 22 65
  2. Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. (PMID: 8314147) Mok S.C. … Berkowitz R.S. (Gynecol. Oncol. 1994) 2 3 4 65
  3. Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130). (PMID: 21832087) Revert-Ros F. … Saus J. (J. Biol. Chem. 2011) 2 3 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. (PMID: 19270026) Quaye L. … Gayther S.A. (Hum. Mol. Genet. 2009) 3 46 65

Products for FILIP1L Gene

Sources for FILIP1L Gene

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