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FILIP1L Gene

protein-coding   GIFtS: 49
GCID: GC03M099548

Filamin A Interacting Protein 1-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Filamin A Interacting Protein 1-Like1 2     GIP902 3
Protein Down-Regulated In Ovarian Cancer 12 3     Downregulated In Ovarian Cancer 11
130 KDa GPBP-Interacting Protein2 3     GPBP-Interacting Protein Of 130 KDa1
90 KDa GPBP-Interacting Protein2 3     GIP1302
DOC-12 3     Filamin A-Interacting Protein 1-Like2
DOC12 3     COL4A3BPIP3

External Ids:    HGNC: 245891   Entrez Gene: 112592   Ensembl: ENSG000001683867   OMIM: 6129935   UniProtKB: Q4L1803   

Export aliases for FILIP1L gene to outside databases

Previous GC identifers: GC03M101035 GC03M096920


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FILIP1L Gene:
FILIP1L (filamin A interacting protein 1-like) is a protein-coding gene. Diseases associated with FILIP1L include ovarian cancer, and cleft lip. An important paralog of this gene is CTTNBP2NL.

UniProtKB/Swiss-Prot: FIL1L_HUMAN, Q4L180
Function: Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in
endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits
melanoma growth When expressed in tumor-associated vasculature




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FILIP1L gene promoter:
         MEF-2   FOXO3   FOXO3b   MEF-2A   S8   FAC1   POU2F1   POU2F1a   FOXO3a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FILIP1L promoter sequence
   Search Chromatin IP Primers for FILIP1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FILIP1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.1   Ensembl cytogenetic band:  3q12.1   HGNC cytogenetic band: 3q12.1

FILIP1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FILIP1L gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M099548:  view genomic region     (about GC identifiers)

Start:
99,548,985 bp from pter      End:
99,833,357 bp from pter
Size:
284,373 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FIL1L_HUMAN, Q4L180 (See protein sequence)
Recommended Name: Filamin A-interacting protein 1-like  
Size: 1135 amino acids; 130382 Da
Sequence caution: Sequence=AAA98972.1; Type=Frameshift; Positions=1000; Sequence=AAN16206.1; Type=Frameshift;
Positions=747; Sequence=ACB37436.1; Type=Frameshift; Positions=750;
Secondary accessions: B2CNV7 B2CNV8 Q13597 Q2YDY5 Q6KFX5 Q6KFX6 Q6KFX7 Q8IUM3 Q8N6Z0
Alternative splicing: 7 isoforms:  Q4L180-1   Q4L180-2   Q4L180-3   Q4L180-4   Q4L180-5   Q4L180-6   Q4L180-7   

Explore the universe of human proteins at neXtProt for FILIP1L: NX_Q4L180

Explore proteomics data for FILIP1L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FILIP1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001035924.1  NP_001269722.1  NP_001269723.1  NP_055705.2  NP_878913.2  

    ENSEMBL proteins: 
     ENSP00000417617   ENSP00000346560   ENSP00000417774   ENSP00000419642   ENSP00000327880  
     ENSP00000419874   ENSP00000381371   ENSP00000373192  

    FILIP1L Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019131 Cortactin-binding_p2_N

    Graphical View of Domain Structure for InterPro Entry Q4L180

    ProtoNet protein and cluster: Q4L180

    UniProtKB/Swiss-Prot: FIL1L_HUMAN, Q4L180
    Similarity: Belongs to the FILIP1 family


    FILIP1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FIL1L_HUMAN, Q4L180
    Function: Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in
    endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits
    melanoma growth When expressed in tumor-associated vasculature
    Induction: Up-regulated in endothelial cells with the angiogenesis inhibitors endostatin and fumagillin. By
    endothelial monocyte-activating polypeptide II in endothelial cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    FILIP1L for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FILIP1L
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FILIP1L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FILIP1L

    miRNA
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    miRTarBase miRNAs that target FILIP1L:
    hsa-mir-21-5p (MIRT031073), hsa-mir-335-5p (MIRT018948)

    Block miRNA regulation of human, mouse, rat FILIP1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FILIP1L (see all 19):
    hsa-miR-411* hsa-miR-3673 hsa-miR-379* hsa-miR-300 hsa-miR-519a hsa-miR-7-1* hsa-miR-1255a hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidFILIP1L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FILIP1L

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    GenScript: all cDNA clones in your preferred vector (see all 3): FILIP1L (NM_001042459)
    Sino Biological Human cDNA Clone for FILIP1L
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FILIP1L

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FILIP1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FIL1L_HUMAN, Q4L180: Cytoplasm. Membrane. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--
    GO:0016459myosin complex ----

    FILIP1L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FILIP1L
    Interactions:

        Search GeneGlobe Interaction Network for FILIP1L

    2 Interacting proteins for FILIP1L (Q4L1803) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543I2D: score=2 
    PLEKHA5Q9HAU03I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    FILIP1L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FILIP1L (FIL1L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FILIP1L gene (5 alternative transcripts): 
    NM_001042459.2  NM_001282793.1  NM_001282794.1  NM_014890.3  NM_182909.3  

    Unigene Cluster for FILIP1L:

    Filamin A interacting protein 1-like
    Hs.104672  [show with all ESTs]
    Unigene Representative Sequence: NM_001042459
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476723 ENST00000477258 ENST00000354552(uc003dtm.3) ENST00000487087
    ENST00000471562 ENST00000331335(uc003dto.3) ENST00000495625 ENST00000398326
    ENST00000468533 ENST00000383694(uc010hpf.3 uc010hpg.3 uc003dtn.3 uc003dtp.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FILIP1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FILIP1L (see all 19):
    hsa-miR-411* hsa-miR-3673 hsa-miR-379* hsa-miR-300 hsa-miR-519a hsa-miR-7-1* hsa-miR-1255a hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidFILIP1L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FILIP1L
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    OriGene ORF clones in mouse, rat for FILIP1L
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    GenScript: all cDNA clones in your preferred vector (see all 3): FILIP1L (NM_001042459)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FILIP1L
    Primer
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    OriGene qPCR primer pairs and template standards for FILIP1L
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FILIP1L
      QuantiTect SYBR Green Assays in human, mouse, rat FILIP1L
      QuantiFast Probe-based Assays in human, mouse, rat FILIP1L

    Additional mRNA sequence: 

    AF329092.1 AF514867.1 AF514868.1 AF514869.1 AK096195.1 AK225855.1 AY642382.1 BC017987.1 
    BC020941.1 BC027860.1 BC093085.1 EU531865.1 EU531866.1 L16887.1 U53445.1 

    16 DOTS entries:

    DT.100777694  DT.100025104  DT.100744951  DT.120914757  DT.455549  DT.75193441  DT.99929459  DT.101964078 
    DT.101964551  DT.95174716  DT.304633  DT.100777691  DT.120914917  DT.65286972  DT.120914822  DT.435762 

    Selected AceView cDNA sequences (see all 173):

    AF514868 BC020941 CA447792 F37351 AX776296 F22190 BM674194 C05084 
    AK096195 AI139164 AI401231 BU150041 AX776294 AX776292 CK823049 AW058260 
    BQ001189 AI435598 BQ271726 BF434332 BG251846 BE875696 BM505450 BI520276 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FILIP1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTATACAA
    FILIP1L Expression
    About this image


    FILIP1L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
    FILIP1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FILIP1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104672

    UniProtKB/Swiss-Prot: FIL1L_HUMAN, Q4L180
    Tissue specificity: Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the
    vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at
    protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FILIP1L gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Filip1l1 , 5 filamin A interacting protein 1-like1, 5 88.44(n)1
    88.76(a)1
      16 (34.22 cM)5
    787491  NM_001040397.41  NP_001035487.21 
     573530935 
    chicken
    (Gallus gallus)
    Aves FILIP1L1 filamin A interacting protein 1-like 73.27(n)
    73.96(a)
      769163  XM_004938244.1  XP_004938301.1 
    lizard
    (Anolis carolinensis)
    Reptilia FILIP1L6
    filamin A interacting protein 1-like
    67(a)
    1 ↔ 1
    3(174273039-174517177)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia filip1l1 filamin A interacting protein 1-like 69.13(n)
    68.95(a)
      100493507  XM_002939865.2  XP_002939911.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1582921 zgc:158292 61.73(n)
    60.07(a)
      100004879  NM_001110486.1  NP_001103956.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG109156
    --
    16(a)
    1 → many
    2R(14048225-14051714)
    worm
    (Caenorhabditis elegans)
    Secernentea C49H3.66
    Protein C49H3.6, isoform a (C49H3.6) mRNA, complet...
    20(a)
    1 → many
    IV(7903740-7907083) WBGene00016792


    ENSEMBL Gene Tree for FILIP1L (if available)
    TreeFam Gene Tree for FILIP1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FILIP1L gene
    CTTNBP2NL2  CTTNBP22  FILIP12  LUZP12  
    3 SIMAP similar genes for FILIP1L using alignment to 3 protein entries:     FIL1L_HUMAN (see all proteins):
    FILIP1    LUZP1    CTTNBP2NL

    FILIP1L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for FILIP1L    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7934401,2,4
    ----see VAR_0509932 mis40--------
    rs283624871,2,4
    ----see VAR_0509942 mis40--------

    HapMap Linkage Disequilibrium report for FILIP1L (99548985 - 99798985 bp, first 250kb of FILIP1L)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FILIP1L (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661948CNV Deletion23128226
    esv2945CNV Deletion18987735
    esv2671411CNV Deletion23128226
    esv2668597CNV Deletion23128226
    esv987776CNV Deletion20482838
    esv2725690CNV Deletion23290073
    esv2725688CNV Deletion23290073
    esv2670786CNV Deletion23128226
    esv4340CNV Deletion18987735
    esv2725689CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FILIP1L
    DNA2.0 Custom Variant and Variant Library Synthesis for FILIP1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612993    OMIM disorders: --

    10 diseases for FILIP1L:    
    About MalaCards
    ovarian cancer    cleft lip    cleft palate    age related macular degeneration
    endotheliitis    melanoma    cerebritis    thyroiditis
    prostate cancer    prostatitis


    FILIP1L for disorders           About GeneDecksing

    Genetic Association Database (GAD): FILIP1L
    Human Genome Epidemiology (HuGE) Navigator: FILIP1L (3 documents)

    Export disorders for FILIP1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FILIP1L gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with FILIP1L)
        Utopia: connect your pdf to the dynamic
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    1. Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells. (PubMed id 15935955)1, 2, 3, 9 Tandle A.T.... Libutti S.K. (Cytokine 2005)
    2. Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. (PubMed id 8314147)1, 2, 3 Mok S.C....Berkowitz R.S. (Gynecol. Oncol. 1994)
    3. Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130). (PubMed id 21832087)1, 3 Revert-Ros F....Saus J. (J. Biol. Chem. 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. (PubMed id 19270026)1, 4 Quaye L.... Gayther S.A. (Hum. Mol. Genet. 2009)
    6. Seven new loci associated with age-related macular degeneration. (PubMed id 23455636)1 Fritsche L.G....Abecasis G.R. (Nat. Genet. 2013)
    7. CpG island hypermethylation frequently silences FILIP1L isoform 2 expression in prostate cancer. (PubMed id 23174249)1 Desotelle J....Jarrard D. (J. Urol. 2013)
    8. Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (PubMed id 23512105)1 Beaty T.H....Ruczinski I. (Hum. Genet. 2013)
    9. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PubMed id 24144296)1 Cheng C.Y....Baird P.N. (Am. J. Hum. Genet. 2013)
    10. Sensitivity to TOP2 targeting chemotherapeutics is regulated by Oct1 and FILIP1L. (PubMed id 22900064)1 Lu H. and Hallstrom T.C. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11259 HGNC: 24589 AceView: DOC1 Ensembl:ENSG00000168386 euGenes: HUgn11259
    ECgene: FILIP1L H-InvDB: FILIP1L

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FILIP1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FILIP1L gene:
    Search GeneIP for patents involving FILIP1L

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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