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Aliases for FILIP1L Gene

Aliases for FILIP1L Gene

  • Filamin A Interacting Protein 1-Like 2 3
  • Protein Down-Regulated In Ovarian Cancer 1 3 4
  • 130 KDa GPBP-Interacting Protein 3 4
  • 90 KDa GPBP-Interacting Protein 3 4
  • Doc-1 3 4
  • GIP90 3 4
  • DOC1 3 4
  • Filamin A-Interacting Protein 1-Like 3
  • GPBP-Interacting Protein Of 130 KDa 2
  • Downregulated In Ovarian Cancer 1 2
  • COL4A3BPIP 4
  • GIP130 3

External Ids for FILIP1L Gene

Previous GeneCards Identifiers for FILIP1L Gene

  • GC03M101035
  • GC03M099548
  • GC03M096920

Summaries for FILIP1L Gene

GeneCards Summary for FILIP1L Gene

FILIP1L (Filamin A Interacting Protein 1-Like) is a Protein Coding gene. An important paralog of this gene is CTTNBP2.

UniProtKB/Swiss-Prot for FILIP1L Gene

  • Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FILIP1L Gene

Genomics for FILIP1L Gene

Regulatory Elements for FILIP1L Gene

Genomic Location for FILIP1L Gene

Start:
99,830,141 bp from pter
End:
100,114,513 bp from pter
Size:
284,373 bases
Orientation:
Minus strand

Genomic View for FILIP1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FILIP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FILIP1L Gene

Proteins for FILIP1L Gene

  • Protein details for FILIP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4L180-FIL1L_HUMAN
    Recommended name:
    Filamin A-interacting protein 1-like
    Protein Accession:
    Q4L180
    Secondary Accessions:
    • B2CNV7
    • B2CNV8
    • Q13597
    • Q2YDY5
    • Q6KFX5
    • Q6KFX6
    • Q6KFX7
    • Q8IUM3
    • Q8N6Z0

    Protein attributes for FILIP1L Gene

    Size:
    1135 amino acids
    Molecular mass:
    130382 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA98972.1; Type=Frameshift; Positions=1000; Evidence={ECO:0000305}; Sequence=AAN16206.1; Type=Frameshift; Positions=747; Evidence={ECO:0000305}; Sequence=ACB37436.1; Type=Frameshift; Positions=750; Evidence={ECO:0000305};

    Alternative splice isoforms for FILIP1L Gene

neXtProt entry for FILIP1L Gene

Proteomics data for FILIP1L Gene at MOPED

Post-translational modifications for FILIP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FILIP1L Gene

Domains for FILIP1L Gene

Protein Domains for FILIP1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FILIP1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4L180

UniProtKB/Swiss-Prot:

FIL1L_HUMAN :
  • Q4L180
Family:
  • Belongs to the FILIP1 family.
genes like me logo Genes that share domains with FILIP1L: view

No data available for Gene Families for FILIP1L Gene

Function for FILIP1L Gene

Molecular function for FILIP1L Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
UniProtKB/Swiss-Prot Induction:
Up-regulated in endothelial cells with the angiogenesis inhibitors endostatin and fumagillin. By endothelial monocyte-activating polypeptide II in endothelial cells.

Gene Ontology (GO) - Molecular Function for FILIP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FILIP1L: view

Animal Model Products

CRISPR Products

miRNA for FILIP1L Gene

miRTarBase miRNAs that target FILIP1L

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FILIP1L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FILIP1L Gene

Localization for FILIP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for FILIP1L Gene

Cytoplasm. Membrane. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FILIP1L Gene COMPARTMENTS Subcellular localization image for FILIP1L gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FILIP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FILIP1L: view

Pathways for FILIP1L Gene

SuperPathways for FILIP1L Gene

No Data Available

Interacting Proteins for FILIP1L Gene

Selected Interacting proteins: Q4L180-FIL1L_HUMAN for FILIP1L Gene via I2D

Symbol External ID(s) Details
APC
PLEKHA5

Gene Ontology (GO) - Biological Process for FILIP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FILIP1L: view

No data available for Pathways by source for FILIP1L Gene

Transcripts for FILIP1L Gene

Unigene Clusters for FILIP1L Gene

Filamin A interacting protein 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FILIP1L

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FILIP1L Gene

No ASD Table

Relevant External Links for FILIP1L Gene

GeneLoc Exon Structure for
FILIP1L
ECgene alternative splicing isoforms for
FILIP1L

Expression for FILIP1L Gene

mRNA expression in normal human tissues for FILIP1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FILIP1L Gene

This gene is overexpressed in Artery - Aorta (7.8) and Artery - Tibial (5.3).

Protein differential expression in normal tissues for FILIP1L Gene

This gene is overexpressed in Uterus (11.9), Plasma (10.7), Gallbladder (10.4), and Colon (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FILIP1L Gene

SOURCE GeneReport for Unigene cluster for FILIP1L Gene Hs.104672

mRNA Expression by UniProt/SwissProt for FILIP1L Gene

Q4L180-FIL1L_HUMAN
Tissue specificity: Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer.
genes like me logo Genes that share expressions with FILIP1L: view

In Situ Assay Products

No data available for Expression partners for FILIP1L Gene

Orthologs for FILIP1L Gene

This gene was present in the common ancestor of animals.

Orthologs for FILIP1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FILIP1L 35
  • 91.92 (n)
  • 93.19 (a)
FILIP1L 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FILIP1L 35
  • 92.02 (n)
  • 92.73 (a)
FILIP1L 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Filip1l 35
  • 88.44 (n)
  • 88.76 (a)
Filip1l 16
Filip1l 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FILIP1L 35
  • 99.67 (n)
  • 99.56 (a)
FILIP1L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Filip1l 35
  • 87.53 (n)
  • 87.77 (a)
oppossum
(Monodelphis domestica)
Mammalia FILIP1L 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FILIP1L 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves FILIP1L 35
  • 73.27 (n)
  • 73.96 (a)
FILIP1L 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FILIP1L 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia filip1l 35
  • 69.13 (n)
  • 68.95 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:158292 35
  • 61.73 (n)
  • 60.07 (a)
FILIP1L (1 of 2) 36
  • 60 (a)
OneToMany
FILIP1L (2 of 2) 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10915 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C49H3.6 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for FILIP1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FILIP1L Gene

ENSEMBL:
Gene Tree for FILIP1L (if available)
TreeFam:
Gene Tree for FILIP1L (if available)

Paralogs for FILIP1L Gene

Paralogs for FILIP1L Gene

Selected SIMAP similar genes for FILIP1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FILIP1L: view

Variants for FILIP1L Gene

Sequence variations from dbSNP and Humsavar for FILIP1L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_050993 -
VAR_050994 -

Structural Variations from Database of Genomic Variants (DGV) for FILIP1L Gene

Variant ID Type Subtype PubMed ID
nsv3918 CNV Insertion 18451855
nsv822194 CNV Loss 20364138
esv2663491 CNV Deletion 23128226
esv2725686 CNV Deletion 23290073
esv2332259 CNV Deletion 18987734
esv2725687 CNV Deletion 23290073
esv988265 CNV Deletion 20482838
esv2945 CNV Deletion 18987735
esv2725688 CNV Deletion 23290073
esv987776 CNV Deletion 20482838
esv2668597 CNV Deletion 23128226
esv26006 CNV Loss 19812545
esv998785 CNV Loss 20482838
dgv818n67 CNV Loss 20364138
esv2507771 CNV Insertion 19546169
esv1177720 CNV Insertion 17803354
esv1440096 CNV Insertion 17803354
nsv822197 CNV Loss 20364138
esv2670786 CNV Deletion 23128226
esv2725689 CNV Deletion 23290073
nsv3919 CNV Insertion 18451855
esv2671411 CNV Deletion 23128226
esv4340 CNV Deletion 18987735
esv2725690 CNV Deletion 23290073
esv2661948 CNV Deletion 23128226

Relevant External Links for FILIP1L Gene

HapMap Linkage Disequilibrium report
FILIP1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FILIP1L Gene

Disorders for FILIP1L Gene

Relevant External Links for FILIP1L

Genetic Association Database (GAD)
FILIP1L
Human Genome Epidemiology (HuGE) Navigator
FILIP1L

No disorders were found for FILIP1L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FILIP1L Gene

Publications for FILIP1L Gene

  1. Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells. (PMID: 15935955) Tandle A.T. … Libutti S.K. (Cytokine 2005) 2 3 4 23
  2. Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. (PMID: 8314147) Mok S.C. … Berkowitz R.S. (Gynecol. Oncol. 1994) 2 3 4
  3. Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130). (PMID: 21832087) Revert-Ros F. … Saus J. (J. Biol. Chem. 2011) 2 3
  4. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. (PMID: 19270026) Quaye L. … Gayther S.A. (Hum. Mol. Genet. 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for FILIP1L Gene

Sources for FILIP1L Gene

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