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Aliases for FILIP1 Gene

Aliases for FILIP1 Gene

  • Filamin A Interacting Protein 1 2 3 5
  • FILIP 3 4
  • Filamin-A-Interacting Protein 1 3
  • KIAA1275 4

External Ids for FILIP1 Gene

Previous GeneCards Identifiers for FILIP1 Gene

  • GC06M075954
  • GC06M076000
  • GC06M076013
  • GC06M076074
  • GC06M076005
  • GC06M073216

Summaries for FILIP1 Gene

Entrez Gene Summary for FILIP1 Gene

  • This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016]

GeneCards Summary for FILIP1 Gene

FILIP1 (Filamin A Interacting Protein 1) is a Protein Coding gene. Diseases associated with FILIP1 include Ureterocele. Among its related pathways are Integrated Breast Cancer Pathway. An important paralog of this gene is FILIP1L.

UniProtKB/Swiss-Prot for FILIP1 Gene

  • By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.

Gene Wiki entry for FILIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FILIP1 Gene

Genomics for FILIP1 Gene

Regulatory Elements for FILIP1 Gene

Enhancers for FILIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G075333 1.4 Ensembl ENCODE dbSUPER 37.9 +159.3 159287 2.1 ZSCAN4 INSM2 ZNF76 KLF17 FEZF1 ZNF2 ZNF366 SCRT2 ZNF362 YY2 FILIP1 ENSG00000237174 TMEM30A LOC100506804 GC06P075349 HMGB1P39
GH06G075347 1.1 Ensembl ENCODE 46.1 +145.1 145066 3.0 SIN3A RAD21 ZBTB40 GLIS2 ZNF366 SCRT2 ZNF362 REST ZEB2 ZNF843 FILIP1 RPL26P20 RNU1-34P MYO6 GC06P075349 HMGB1P39
GH06G075430 1.5 FANTOM5 Ensembl ENCODE dbSUPER 25.8 +62.3 62336 2.1 RFX1 JUN GFI1B ZEB2 ZNF398 ZNF507 ZSCAN21 JUND SCRT2 FOS FILIP1 RNU1-34P RPL26P20 SENP6 MIR4463 PIR50339
GH06G075332 0.6 Ensembl dbSUPER 50.3 +161.1 161129 0.2 POLR2A FILIP1 ENSG00000237174 RNU1-34P RPL26P20 HMGB1P39 GC06P075349
GH06G075326 0.7 ENCODE dbSUPER 39.7 +166.7 166711 0.8 BCL11A CEBPB FOS FILIP1 HMGB1P39 GC06P075349
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FILIP1 on UCSC Golden Path with GeneCards custom track

Promoters for FILIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000199062 528 1799 TBP ZNF146 FEZF1 RELA CBX5 ZNF143 ZNF600 RELB CHD1 NR3C1

Genomic Location for FILIP1 Gene

Chromosome:
6
Start:
75,291,859 bp from pter
End:
75,493,829 bp from pter
Size:
201,971 bases
Orientation:
Minus strand

Genomic View for FILIP1 Gene

Genes around FILIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FILIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FILIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FILIP1 Gene

Proteins for FILIP1 Gene

  • Protein details for FILIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7B0-FLIP1_HUMAN
    Recommended name:
    Filamin-A-interacting protein 1
    Protein Accession:
    Q7Z7B0
    Secondary Accessions:
    • B2RMU6
    • Q5VUL6
    • Q86TC3
    • Q8N8B9
    • Q96SK6
    • Q9NVI8
    • Q9ULE5

    Protein attributes for FILIP1 Gene

    Size:
    1213 amino acids
    Molecular mass:
    138109 Da
    Quaternary structure:
    • Interacts with FLNA. Interacts with RHOD (in GTP-bound form).
    SequenceCaution:
    • Sequence=BAA91763.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH71818.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73614.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FILIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FILIP1 Gene

Post-translational modifications for FILIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FILIP1 Gene

No data available for DME Specific Peptides for FILIP1 Gene

Domains & Families for FILIP1 Gene

Protein Domains for FILIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FILIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7B0

UniProtKB/Swiss-Prot:

FLIP1_HUMAN :
  • Belongs to the FILIP1 family.
Family:
  • Belongs to the FILIP1 family.
genes like me logo Genes that share domains with FILIP1: view

No data available for Gene Families for FILIP1 Gene

Function for FILIP1 Gene

Molecular function for FILIP1 Gene

UniProtKB/Swiss-Prot Function:
By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.
genes like me logo Genes that share phenotypes with FILIP1: view

Animal Model Products

CRISPR Products

miRNA for FILIP1 Gene

miRTarBase miRNAs that target FILIP1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FILIP1 Gene

Localization for FILIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FILIP1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FILIP1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for FILIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with FILIP1: view

Pathways & Interactions for FILIP1 Gene

genes like me logo Genes that share pathways with FILIP1: view

Pathways by source for FILIP1 Gene

1 BioSystems pathway for FILIP1 Gene

Gene Ontology (GO) - Biological Process for FILIP1 Gene

None

No data available for SIGNOR curated interactions for FILIP1 Gene

Drugs & Compounds for FILIP1 Gene

No Compound Related Data Available

Transcripts for FILIP1 Gene

Unigene Clusters for FILIP1 Gene

Filamin A interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FILIP1 Gene

No ASD Table

Relevant External Links for FILIP1 Gene

GeneLoc Exon Structure for
FILIP1
ECgene alternative splicing isoforms for
FILIP1

Expression for FILIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FILIP1 Gene

mRNA differential expression in normal tissues according to GTEx for FILIP1 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.9), Muscle - Skeletal (x6.6), and Heart - Atrial Appendage (x4.7).

Protein differential expression in normal tissues from HIPED for FILIP1 Gene

This gene is overexpressed in Spinal cord (12.2), Urinary Bladder (10.1), Heart (9.0), Colon (8.9), Adrenal (7.1), and Fetal heart (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FILIP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FILIP1 Gene:

FILIP1

SOURCE GeneReport for Unigene cluster for FILIP1 Gene:

Hs.696158

mRNA Expression by UniProt/SwissProt for FILIP1 Gene:

Q7Z7B0-FLIP1_HUMAN
Tissue specificity: Moderately expressed in adult heart and brain. Weakly expressed in lung, skeletal muscle, ovary, testis, kidney, and fetal brain, and hardly detectable in liver, pancreas, spleen, and fetal liver. Within brain, moderate expression is found in amygdala and caudate nucleus.

Evidence on tissue expression from TISSUES for FILIP1 Gene

  • Muscle(4.5)
  • Nervous system(4.4)
  • Intestine(4.2)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with FILIP1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FILIP1 Gene

Orthologs for FILIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FILIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FILIP1 34 35
  • 99.73 (n)
oppossum
(Monodelphis domestica)
Mammalia FILIP1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FILIP1 34 35
  • 91.37 (n)
cow
(Bos Taurus)
Mammalia FILIP1 34 35
  • 86.95 (n)
rat
(Rattus norvegicus)
Mammalia Filip1 34
  • 85.07 (n)
mouse
(Mus musculus)
Mammalia Filip1 34 16 35
  • 84.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FILIP1 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves FILIP1 34 35
  • 80.06 (n)
lizard
(Anolis carolinensis)
Reptilia FILIP1 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia filip1 34
  • 73.16 (n)
Str.7271 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6145 34
zebrafish
(Danio rerio)
Actinopterygii filip1b 34 35
  • 65.42 (n)
filip1a 35
  • 51 (a)
OneToMany
wufb92f04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9783 34
fruit fly
(Drosophila melanogaster)
Insecta CG10915 35
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C49H3.6 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for FILIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FILIP1 Gene

ENSEMBL:
Gene Tree for FILIP1 (if available)
TreeFam:
Gene Tree for FILIP1 (if available)

Paralogs for FILIP1 Gene

Paralogs for FILIP1 Gene

(1) SIMAP similar genes for FILIP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FILIP1: view

Variants for FILIP1 Gene

Sequence variations from dbSNP and Humsavar for FILIP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs35464830 Benign 75,314,349(-) GCCTA(A/G)AAGAT reference, missense
rs371050880 Benign 75,314,909(+) ACCTC(A/G)AAGCC reference, missense
rs374887916 Benign 75,312,516(+) AGTGC(C/G/T)GGTGG reference, missense
rs1000023340 -- 75,350,599(+) AGTAC(A/T)CTGTG intron-variant
rs1000028288 -- 75,402,593(+) ATGGA(A/C)CTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FILIP1 Gene

Variant ID Type Subtype PubMed ID
dgv10785n54 CNV loss 21841781
dgv10786n54 CNV loss 21841781
dgv1802e212 CNV loss 25503493
esv1005015 CNV deletion 20482838
esv1350235 CNV deletion 17803354
esv21616 CNV loss 19812545
esv2732314 CNV deletion 23290073
esv3086938 CNV deletion 24192839
esv3385538 CNV insertion 20981092
esv3540003 CNV deletion 23714750
esv3571210 CNV loss 25503493
esv3609574 CNV loss 21293372
esv3890880 CNV loss 25118596
nsv1114843 CNV deletion 24896259
nsv348407 CNV deletion 16902084
nsv603763 CNV loss 21841781
nsv603764 CNV loss 21841781
nsv603770 CNV loss 21841781
nsv830698 CNV gain 17160897
nsv981158 CNV duplication 23825009

Variation tolerance for FILIP1 Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FILIP1 Gene

Human Gene Mutation Database (HGMD)
FILIP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FILIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FILIP1 Gene

Disorders for FILIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FILIP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ureterocele
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FILIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FILIP1
genes like me logo Genes that share disorders with FILIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FILIP1 Gene

Publications for FILIP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. (PMID: 23087206) Gad A.K. … AspenstrAPm P. (Mol. Biol. Cell 2012) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3 64

Products for FILIP1 Gene

Sources for FILIP1 Gene

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