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Aliases for FIGNL2 Gene

Aliases for FIGNL2 Gene

  • Fidgetin Like 2 2 3 5
  • Fidgetin-Like 2 2

External Ids for FIGNL2 Gene

Previous GeneCards Identifiers for FIGNL2 Gene

  • GC12M050497
  • GC12M052211

Summaries for FIGNL2 Gene

GeneCards Summary for FIGNL2 Gene

FIGNL2 (Fidgetin Like 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIGNL2 Gene

Genomics for FIGNL2 Gene

Regulatory Elements for FIGNL2 Gene

Enhancers for FIGNL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F051855 1.2 FANTOM5 Ensembl ENCODE 2.6 -7.4 -7369 1.3 SOX13 CTCF TBP TEAD4 CEBPB REST NR3C1 TEAD3 JUND MAFF ANKRD33 SLC4A8 NR4A1 GRASP GALNT6 FIGNL2
GH12F052180 1.3 FANTOM5 Ensembl ENCODE 2.5 -339.7 -339705 15.1 PKNOX1 SIN3A FEZF1 ZNF2 GLIS2 ELK1 ZNF416 FOS ZNF263 SP3 KRT80 KRT7 ZNF740 C12orf80 NR4A1 FIGNL2 ACVRL1 ATG101 GRASP ACVR1B
GH12F051846 1.3 FANTOM5 ENCODE 2.2 +0.8 760 3.1 PKNOX1 SIN3A ZBTB40 GLIS2 EGR2 SP3 ZEB2 SREBF1 ZNF341 GLIS1 SLC4A8 ACVRL1 ENSG00000261586 RNU6-574P GALNT6 ANKRD33 FIGNL2 SCN8A LOC105369971
GH12F051368 1.1 FANTOM5 Ensembl ENCODE 1.6 +478.3 478304 4.9 PKNOX1 FEZF1 YY1 ZNF143 FOS DEK JUNB TBX21 SMARCA4 GLIS1 GALNT6 CELA1 BIN2 SLC4A8 DAZAP2 CSRNP2 FIGNL2 SLC11A2
GH12F051863 1.4 Ensembl ENCODE 0.3 -16.1 -16080 3.7 CTCF PKNOX1 TEAD4 ZIC2 RARA TEAD3 ZFHX2 ZNF316 POLR2A HNF4G ANKRD33 FIGNL2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FIGNL2 on UCSC Golden Path with GeneCards custom track

Promoters for FIGNL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001777224 660 2601 CTCF PKNOX1 SIN3A BCL11B ZIC2 HIC1 ZFHX2 GLIS2 POLR2A PATZ1

Genomic Location for FIGNL2 Gene

Chromosome:
12
Start:
51,817,892 bp from pter
End:
51,848,760 bp from pter
Size:
30,869 bases
Orientation:
Minus strand

Genomic View for FIGNL2 Gene

Genes around FIGNL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIGNL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIGNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIGNL2 Gene

Proteins for FIGNL2 Gene

  • Protein details for FIGNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMB9-FIGL2_HUMAN
    Recommended name:
    Putative fidgetin-like protein 2
    Protein Accession:
    A6NMB9

    Protein attributes for FIGNL2 Gene

    Size:
    653 amino acids
    Molecular mass:
    66603 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FIGNL2 Gene

Post-translational modifications for FIGNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FIGNL2 Gene

No data available for DME Specific Peptides for FIGNL2 Gene

Domains & Families for FIGNL2 Gene

Gene Families for FIGNL2 Gene

Protein Domains for FIGNL2 Gene

Suggested Antigen Peptide Sequences for FIGNL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMB9

UniProtKB/Swiss-Prot:

FIGL2_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with FIGNL2: view

Function for FIGNL2 Gene

Gene Ontology (GO) - Molecular Function for FIGNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008568 microtubule-severing ATPase activity IBA --
genes like me logo Genes that share ontologies with FIGNL2: view

Phenotypes for FIGNL2 Gene

GenomeRNAi human phenotypes for FIGNL2:
genes like me logo Genes that share phenotypes with FIGNL2: view

Animal Model Products

miRNA for FIGNL2 Gene

miRTarBase miRNAs that target FIGNL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIGNL2 Gene

Localization for FIGNL2 Gene

Gene Ontology (GO) - Cellular Components for FIGNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FIGNL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FIGNL2 Gene

Pathways & Interactions for FIGNL2 Gene

SuperPathways for FIGNL2 Gene

No Data Available

Interacting Proteins for FIGNL2 Gene

Gene Ontology (GO) - Biological Process for FIGNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010569 regulation of double-strand break repair via homologous recombination IBA --
GO:0031122 cytoplasmic microtubule organization IBA --
genes like me logo Genes that share ontologies with FIGNL2: view

No data available for Pathways by source and SIGNOR curated interactions for FIGNL2 Gene

Transcripts for FIGNL2 Gene

mRNA/cDNA for FIGNL2 Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FIGNL2 Gene

Fidgetin-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIGNL2 Gene

No ASD Table

Relevant External Links for FIGNL2 Gene

GeneLoc Exon Structure for
FIGNL2
ECgene alternative splicing isoforms for
FIGNL2

Expression for FIGNL2 Gene

mRNA expression in normal human tissues for FIGNL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of FIGNL2 Gene:

FIGNL2

SOURCE GeneReport for Unigene cluster for FIGNL2 Gene:

Hs.648218
genes like me logo Genes that share expression patterns with FIGNL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FIGNL2 Gene

Orthologs for FIGNL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FIGNL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIGNL2 34
  • 96.45 (n)
cow
(Bos Taurus)
Mammalia FIGNL2 34
  • 88.62 (n)
rat
(Rattus norvegicus)
Mammalia Fignl2 34
  • 85.66 (n)
mouse
(Mus musculus)
Mammalia Fignl2 34 16
  • 83.93 (n)
Species where no ortholog for FIGNL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FIGNL2 Gene

ENSEMBL:
Gene Tree for FIGNL2 (if available)
TreeFam:
Gene Tree for FIGNL2 (if available)

Paralogs for FIGNL2 Gene

(1) SIMAP similar genes for FIGNL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FIGNL2: view

No data available for Paralogs for FIGNL2 Gene

Variants for FIGNL2 Gene

Sequence variations from dbSNP and Humsavar for FIGNL2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10747623 -- 51,825,553(+) CACGA(A/T)GTCTC intron-variant
rs10747624 -- 51,825,603(+) GGGGA(A/C)CTTGT intron-variant
rs10783478 -- 51,838,692(+) TAGCT(A/G)GAGGG intron-variant
rs10876210 -- 51,826,098(+) TCTTG(C/T)ACCCA intron-variant
rs10876211 -- 51,831,189(+) AAAAA(C/T)AAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FIGNL2 Gene

Variant ID Type Subtype PubMed ID
dgv2625n54 CNV gain 21841781
dgv2626n54 CNV gain+loss 21841781
dgv2627n54 CNV gain 21841781
dgv2628n54 CNV loss 21841781
esv2659984 CNV deletion 23128226
esv28148 CNV loss 19812545
nsv558878 CNV gain 21841781
nsv558879 CNV loss 21841781
nsv558885 CNV gain 21841781
nsv558893 CNV loss 21841781
nsv826373 CNV gain 20364138
nsv826374 CNV gain 20364138

Relevant External Links for FIGNL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIGNL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FIGNL2 Gene

Disorders for FIGNL2 Gene

Relevant External Links for FIGNL2

Genetic Association Database (GAD)
FIGNL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FIGNL2

No disorders were found for FIGNL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIGNL2 Gene

Publications for FIGNL2 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  2. The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development. (PMID: 11017077) Cox G.A. … Frankel W.N. (Nat. Genet. 2000) 2 3 64
  3. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 46 64
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for FIGNL2 Gene

Sources for FIGNL2 Gene

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