Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FIGNL1 Gene

Aliases for FIGNL1 Gene

  • Fidgetin-Like 1 2 3
  • EC 3.6.4.- 4
  • EC 3.6.4 63

External Ids for FIGNL1 Gene

Previous GeneCards Identifiers for FIGNL1 Gene

  • GC07M049976
  • GC07M050219
  • GC07M050253
  • GC07M050286
  • GC07M050479

Summaries for FIGNL1 Gene

GeneCards Summary for FIGNL1 Gene

FIGNL1 (Fidgetin-Like 1) is a Protein Coding gene. Diseases associated with FIGNL1 include autism spectrum disorder. GO annotations related to this gene include magnesium ion binding and nucleoside-triphosphatase activity. An important paralog of this gene is FIGN.

UniProtKB/Swiss-Prot for FIGNL1 Gene

  • Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIGNL1 Gene

Genomics for FIGNL1 Gene

Regulatory Elements for FIGNL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FIGNL1 Gene

Start:
50,444,128 bp from pter
End:
50,542,535 bp from pter
Size:
98,408 bases
Orientation:
Minus strand

Genomic View for FIGNL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FIGNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIGNL1 Gene

Proteins for FIGNL1 Gene

  • Protein details for FIGNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIW4-FIGL1_HUMAN
    Recommended name:
    Fidgetin-like protein 1
    Protein Accession:
    Q6PIW4
    Secondary Accessions:
    • D3DVM6
    • Q86V18
    • Q8ND59
    • Q9H8P1
    • Q9H917

    Protein attributes for FIGNL1 Gene

    Size:
    674 amino acids
    Molecular mass:
    74077 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Hexamer (By similarity). Interacts (via N-terminal one-half region) with RAD51; the interaction is direct. Interacts (via N-terminal one-half region) with SPIDR (via the C-terminal region); the interaction is direct.
    SequenceCaution:
    • Sequence=BAB14567.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FIGNL1 Gene

    Alternative splice isoforms for FIGNL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FIGNL1 Gene

Proteomics data for FIGNL1 Gene at MOPED

Selected DME Specific Peptides for FIGNL1 Gene

Post-translational modifications for FIGNL1 Gene

  • Ubiquitination at Lys258
  • Modification sites at PhosphoSitePlus

Domains for FIGNL1 Gene

Gene Families for FIGNL1 Gene

HGNC:
  • AATP :ATPases / AAA-type

Protein Domains for FIGNL1 Gene

Suggested Antigen Peptide Sequences for FIGNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PIW4

UniProtKB/Swiss-Prot:

FIGL1_HUMAN :
  • Q6PIW4
Domain:
  • The N-terminus is necessary for its recruitment to DNA damage sites
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with FIGNL1: view

Function for FIGNL1 Gene

Molecular function for FIGNL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation.

Enzyme Numbers (IUBMB) for FIGNL1 Gene

Gene Ontology (GO) - Molecular Function for FIGNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0005515 protein binding IPI 23754376
GO:0005524 ATP binding IEA --
GO:0008568 microtubule-severing ATPase activity IBA --
GO:0009378 four-way junction helicase activity --
genes like me logo Genes that share ontologies with FIGNL1: view

Animal Model Products

CRISPR Products

miRNA for FIGNL1 Gene

miRTarBase miRNAs that target FIGNL1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FIGNL1 Gene

Localization for FIGNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIGNL1 Gene

Nucleus. Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FIGNL1 Gene COMPARTMENTS Subcellular localization image for FIGNL1 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FIGNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 23754376
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FIGNL1: view

Pathways for FIGNL1 Gene

SuperPathways for FIGNL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIGNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation ISS --
GO:0006281 DNA repair --
GO:0006310 DNA recombination --
GO:0010569 regulation of double-strand break repair via homologous recombination IDA 23754376
GO:0031122 cytoplasmic microtubule organization IBA --
genes like me logo Genes that share ontologies with FIGNL1: view

No data available for Pathways by source for FIGNL1 Gene

Compounds for FIGNL1 Gene

(1) HMDB Compounds for FIGNL1 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with FIGNL1: view

Transcripts for FIGNL1 Gene

Unigene Clusters for FIGNL1 Gene

Fidgetin-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FIGNL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIGNL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d · 7e · 7f ·
SP1: - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: - -
SP13: - - - - -
SP14: - - -
SP15: - - - - - - - - -
SP16: - - - - - - - - -
SP17: - - - - - - - -
SP18: - - - - - - - - - -
SP19: -

ExUns: 7g · 7h
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for FIGNL1 Gene

GeneLoc Exon Structure for
FIGNL1
ECgene alternative splicing isoforms for
FIGNL1

Expression for FIGNL1 Gene

mRNA expression in normal human tissues for FIGNL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FIGNL1 Gene

SOURCE GeneReport for Unigene cluster for FIGNL1 Gene Hs.137516

genes like me logo Genes that share expressions with FIGNL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FIGNL1 Gene

Orthologs for FIGNL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FIGNL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIGNL1 35
  • 99.41 (n)
  • 98.96 (a)
FIGNL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FIGNL1 35
  • 86.35 (n)
  • 85.61 (a)
FIGNL1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FIGNL1 35
  • 83.18 (n)
  • 83.83 (a)
FIGNL1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fignl1 35
  • 82.91 (n)
  • 77.71 (a)
Fignl1 16
Fignl1 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FIGNL1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FIGNL1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fignl1 35
  • 82.66 (n)
  • 79.05 (a)
chicken
(Gallus gallus)
Aves FIGNL1 35
  • 71.56 (n)
  • 73.16 (a)
FIGNL1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FIGNL1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fignl1 35
  • 65.78 (n)
  • 65.05 (a)
zebrafish
(Danio rerio)
Actinopterygii fignl1 35
  • 59.4 (n)
  • 59.97 (a)
fignl1 36
  • 57 (a)
OneToOne
wufj99a11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007769 35
  • 60.73 (n)
  • 64.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3326 35
  • 53.63 (n)
  • 49.44 (a)
CG3326 36
  • 39 (a)
OneToMany
CG3326 37
  • 46 (a)
CG10793 37
  • 37 (a)
BG:DS06874.3 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea figl-1 36
  • 40 (a)
OneToMany
K04D7.2b 37
  • 38 (a)
F32D1.1 37
  • 49 (a)
K04D7.2a 37
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAP1 36
  • 23 (a)
ManyToMany
YTA6 36
  • 27 (a)
ManyToMany
YTA6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G27120 35
  • 54.56 (n)
  • 51.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9574 36
  • 74 (a)
OneToOne
Species with no ortholog for FIGNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FIGNL1 Gene

ENSEMBL:
Gene Tree for FIGNL1 (if available)
TreeFam:
Gene Tree for FIGNL1 (if available)

Paralogs for FIGNL1 Gene

Paralogs for FIGNL1 Gene

Selected SIMAP similar genes for FIGNL1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FIGNL1: view

Variants for FIGNL1 Gene

Sequence variations from dbSNP and Humsavar for FIGNL1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs935795 -- 50,450,694(-) TCCCG(A/G)GTGGG upstream-variant-2KB
rs1037350 -- 50,448,093(-) ATTGC(G/T)TGATT intron-variant, upstream-variant-2KB
rs1470746 -- 50,444,816(-) GATCT(C/T)AAAGC utr-variant-3-prime
rs2305358 -- 50,444,586(-) CAAAA(A/G)CAAGT utr-variant-3-prime
rs2305359 -- 50,444,409(-) ACAGC(A/G)GTAGG utr-variant-3-prime

Relevant External Links for FIGNL1 Gene

HapMap Linkage Disequilibrium report
FIGNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FIGNL1 Gene

Disorders for FIGNL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FIGNL1 Gene including...

Search for FIGNL1 Gene in MalaCards »

Relevant External Links for FIGNL1

Genetic Association Database (GAD)
FIGNL1
Human Genome Epidemiology (HuGE) Navigator
FIGNL1
genes like me logo Genes that share disorders with FIGNL1: view

No data available for UniProtKB/Swiss-Prot for FIGNL1 Gene

Publications for FIGNL1 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M. … van Ree J.M. (Biol. Psychiatry 2009) 3 48
  5. FIGNL1-containing protein complex is required for efficient homologous recombination repair. (PMID: 23754376) Yuan J. … Chen J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4

Products for FIGNL1 Gene

Sources for FIGNL1 Gene

Back to Top

Content