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Aliases for FIGNL1 Gene

Aliases for FIGNL1 Gene

  • Fidgetin-Like 1 2 3
  • EC 3.6.4.- 4
  • EC 3.6.4 63

External Ids for FIGNL1 Gene

Previous GeneCards Identifiers for FIGNL1 Gene

  • GC07M049976
  • GC07M050219
  • GC07M050253
  • GC07M050286
  • GC07M050479
  • GC07M050361

Summaries for FIGNL1 Gene

GeneCards Summary for FIGNL1 Gene

FIGNL1 (Fidgetin-Like 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and four-way junction helicase activity. An important paralog of this gene is FIGN.

UniProtKB/Swiss-Prot for FIGNL1 Gene

  • Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIGNL1 Gene

Genomics for FIGNL1 Gene

Regulatory Elements for FIGNL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FIGNL1 Gene

Chromosome:
7
Start:
50,444,128 bp from pter
End:
50,542,535 bp from pter
Size:
98,408 bases
Orientation:
Minus strand

Genomic View for FIGNL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FIGNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIGNL1 Gene

Proteins for FIGNL1 Gene

  • Protein details for FIGNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIW4-FIGL1_HUMAN
    Recommended name:
    Fidgetin-like protein 1
    Protein Accession:
    Q6PIW4
    Secondary Accessions:
    • D3DVM6
    • Q86V18
    • Q8ND59
    • Q9H8P1
    • Q9H917

    Protein attributes for FIGNL1 Gene

    Size:
    674 amino acids
    Molecular mass:
    74077 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Hexamer (By similarity). Interacts (via N-terminal one-half region) with RAD51; the interaction is direct. Interacts (via N-terminal one-half region) with SPIDR (via the C-terminal region); the interaction is direct.
    SequenceCaution:
    • Sequence=BAB14567.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FIGNL1 Gene

    Alternative splice isoforms for FIGNL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FIGNL1 Gene

Proteomics data for FIGNL1 Gene at MOPED

Selected DME Specific Peptides for FIGNL1 Gene

Post-translational modifications for FIGNL1 Gene

  • Ubiquitination at Lys 258
  • Modification sites at PhosphoSitePlus

Domains & Families for FIGNL1 Gene

Protein Domains for FIGNL1 Gene

Suggested Antigen Peptide Sequences for FIGNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PIW4

UniProtKB/Swiss-Prot:

FIGL1_HUMAN :
  • The N-terminus is necessary for its recruitment to DNA damage sites
  • Belongs to the AAA ATPase family.
Domain:
  • The N-terminus is necessary for its recruitment to DNA damage sites
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with FIGNL1: view

Function for FIGNL1 Gene

Molecular function for FIGNL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation.

Enzyme Numbers (IUBMB) for FIGNL1 Gene

Gene Ontology (GO) - Molecular Function for FIGNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0005515 protein binding IPI 23754376
GO:0005524 ATP binding IEA --
GO:0008568 microtubule-severing ATPase activity IBA --
GO:0016787 hydrolase activity ISS --
genes like me logo Genes that share ontologies with FIGNL1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FIGNL1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FIGNL1 Gene

Localization for FIGNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIGNL1 Gene

Nucleus. Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FIGNL1 Gene COMPARTMENTS Subcellular localization image for FIGNL1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FIGNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 23754376
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FIGNL1: view

Pathways & Interactions for FIGNL1 Gene

SuperPathways for FIGNL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIGNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation ISS --
GO:0010569 regulation of double-strand break repair via homologous recombination IDA 23754376
GO:0031122 cytoplasmic microtubule organization IBA --
GO:0033687 osteoblast proliferation ISS --
GO:0043066 negative regulation of apoptotic process ISS --
genes like me logo Genes that share ontologies with FIGNL1: view

No data available for Pathways by source and SIGNOR curated interactions for FIGNL1 Gene

Drugs & Compounds for FIGNL1 Gene

(2) Drugs for FIGNL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(3) Additional Compounds for FIGNL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with FIGNL1: view

Transcripts for FIGNL1 Gene

Unigene Clusters for FIGNL1 Gene

Fidgetin-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FIGNL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIGNL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d · 7e · 7f ·
SP1: - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: - -
SP13: - - - - -
SP14: - - -
SP15: - - - - - - - - -
SP16: - - - - - - - - -
SP17: - - - - - - - -
SP18: - - - - - - - - - -
SP19: -

ExUns: 7g · 7h
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for FIGNL1 Gene

GeneLoc Exon Structure for
FIGNL1
ECgene alternative splicing isoforms for
FIGNL1

Expression for FIGNL1 Gene

mRNA expression in normal human tissues for FIGNL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FIGNL1 Gene

This gene is overexpressed in Cervix (31.6), Tlymphocyte (12.8), Blymphocyte (11.5), and Monocytes (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FIGNL1 Gene



SOURCE GeneReport for Unigene cluster for FIGNL1 Gene Hs.137516

genes like me logo Genes that share expression patterns with FIGNL1: view

Protein tissue co-expression partners for FIGNL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FIGNL1 Gene

Orthologs for FIGNL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FIGNL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FIGNL1 35
  • 86.35 (n)
  • 85.61 (a)
FIGNL1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FIGNL1 35
  • 83.18 (n)
  • 83.83 (a)
FIGNL1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fignl1 35
  • 82.91 (n)
  • 77.71 (a)
Fignl1 16
Fignl1 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FIGNL1 35
  • 99.41 (n)
  • 98.96 (a)
FIGNL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fignl1 35
  • 82.66 (n)
  • 79.05 (a)
oppossum
(Monodelphis domestica)
Mammalia FIGNL1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FIGNL1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves FIGNL1 35
  • 71.56 (n)
  • 73.16 (a)
FIGNL1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FIGNL1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fignl1 35
  • 65.78 (n)
  • 65.05 (a)
zebrafish
(Danio rerio)
Actinopterygii fignl1 35
  • 59.4 (n)
  • 59.97 (a)
wufj99a11 35
fignl1 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BG:DS06874.3 37
  • 39 (a)
CG10793 37
  • 37 (a)
CG3326 37
  • 46 (a)
CG3326 35
  • 53.63 (n)
  • 49.44 (a)
CG3326 36
  • 39 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007769 35
  • 60.73 (n)
  • 64.69 (a)
worm
(Caenorhabditis elegans)
Secernentea F32D1.1 37
  • 49 (a)
K04D7.2a 37
  • 38 (a)
K04D7.2b 37
  • 38 (a)
figl-1 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAP1 36
  • 23 (a)
ManyToMany
YTA6 36
  • 27 (a)
ManyToMany
YTA6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G27120 35
  • 54.56 (n)
  • 51.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9574 36
  • 74 (a)
OneToOne
Species with no ortholog for FIGNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FIGNL1 Gene

ENSEMBL:
Gene Tree for FIGNL1 (if available)
TreeFam:
Gene Tree for FIGNL1 (if available)

Paralogs for FIGNL1 Gene

Paralogs for FIGNL1 Gene

(7) SIMAP similar genes for FIGNL1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FIGNL1: view

Variants for FIGNL1 Gene

Sequence variations from dbSNP and Humsavar for FIGNL1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs186412970 -- 50,447,365(+) AATTT(G/T)GAAAC intron-variant
rs185748601 -- 50,444,132(+) AAAAG(C/T)TTTAA utr-variant-3-prime
rs185003173 -- 50,445,170(+) ATATA(C/T)TCTTA utr-variant-3-prime
rs184881035 -- 50,450,495(+) TCCGA(C/G)CAGTG upstream-variant-2KB
rs184697763 -- 50,450,923(+) ATCAC(C/T)TCCGC upstream-variant-2KB

Variation tolerance for FIGNL1 Gene

Residual Variation Intolerance Score: 23.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIGNL1 Gene

HapMap Linkage Disequilibrium report
FIGNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FIGNL1 Gene

Disorders for FIGNL1 Gene

Relevant External Links for FIGNL1

Genetic Association Database (GAD)
FIGNL1
Human Genome Epidemiology (HuGE) Navigator
FIGNL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FIGNL1
genes like me logo Genes that share disorders with FIGNL1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIGNL1 Gene

Publications for FIGNL1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. FIGNL1-containing protein complex is required for efficient homologous recombination repair. (PMID: 23754376) Yuan J. … Chen J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 67
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 67

Products for FIGNL1 Gene

Sources for FIGNL1 Gene

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