FIGN Gene
protein-coding GIFtS: 48
GCID: GC02M164430
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|
fidgetin
| |
Aliases
for FIGN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Export aliases for FIGN gene to outside databasesPrevious GC identifers: GC02M162519 GC02M163005 GC02M164668 GC02M164666 GC02M164289 GC02M164172 GC02M156346 |
Summaries
for FIGN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FIGN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FIGN gene promoter:
Max1 USF1 FOXD3 Nkx2-5 SRY S8 USF-1 Sox9 ZID RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for FIGN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FIGN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q24FIGN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M164430: view genomic region
(about GC identifiers)
Start:
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164,449,906 bp from pter |
End:
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164,592,522 bp from pter |
Size:
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142,617 bases |
Orientation:
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minus strand |
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Proteins
for FIGN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FIGN_HUMAN, Q5HY92 (See
protein sequence)Recommended Name: Fidgetin Size: 759 amino acids; 82146 Da
Subunit: Interacts with AKAP8 (via C-terminus) (By similarity)
Subcellular location: Nucleus matrix (By similarity)
Sequence caution: Sequence=AAX81992.1; Type=Erroneous gene model prediction; Sequence=BAA91590.1; Type=Erroneousinitiation; Sequence=BAB15231.1; Type=Erroneous initiation;
Secondary accessions: B3KWM0 Q9H6M5 Q9NVZ9Explore the universe of human proteins at neXtProt for FIGN: NX_Q5HY92
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5HY92
FIGN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060556.2
ENSEMBL proteins: ENSP00000386768 ENSP00000333836
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016363 | nuclear matrix |
ISS | -- |
FIGN for ontologies About GeneDecksing
FIGN Antibody Products:
Assay Products for FIGN: |
Protein
Domains /
Families
for FIGN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FIGN for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5HY92ProtoNet protein and cluster: Q5HY92 1 Blocks protein family: IPB003960 AAA-protein subdomain
UniProtKB/Swiss-Prot: FIGN_HUMAN, Q5HY92Similarity: Belongs to the AAA ATPase family |
Function
for FIGN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIGN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIGN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FIGN (NM_018086) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FIGN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGN |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0008022 | protein C-terminus binding |
IEA | -- | | GO:0017111 | nucleoside-triphosphatase activity |
IEA | -- |
FIGN for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for FIGN:
Animal Models:
15/19 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Fign) (see all 19):
FIGN for phenotypes About GeneDecksing
|
Pathways & Interactions
for FIGN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FIGN
|
Drugs & Compounds
for FIGN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FIGN
Search CenterWatch for drugs/clinical trials and news about FIGN
|
Transcripts
for FIGN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FIGN gene: NM_018086.2 Unigene Cluster for FIGN: Fidgetin Hs.593650 [show with all ESTs]Unigene Representative Sequence: BX6491054 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409634 ENST00000333129(uc002uck.1) ENST00000482917 ENST00000460250
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIGN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIGN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FIGN (NM_018086) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FIGN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGN |
Additional cDNA sequence: AK001267.1 AK025747.1 AK125324.1 BX649105.1 1 DOTS entry: DT.91657753 22 AceView cDNA sequences: N20508 BX497903 NM_018086 AK001267 AK025747 CK821669 AK125324 R00658 CK821668 BF438393 BX649105 AU124751 BX501897 BM311822 CD101939 BM311232 BF029806 AU148548 BX101827 AI827675 N25413 BG877433
GeneLoc Exon Structure
|
Expression
for FIGN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FIGN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATAAGCAGA
About this image
See FIGN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FIGN
SOURCE GeneReport for Unigene cluster: Hs.593650
SABiosciences Custom PCR Arrays for FIGN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FIGN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FIGN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FIGN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FIGN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGN |
Orthologs
for FIGN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FIGN gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for FIGN (if available)
TreeFam Gene Tree for FIGN (if available) |
Paralogs
for FIGN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FIGN gene
- SPAST2 IQCA12 FIGNL12
7 SIMAP similar genes for FIGN using alignment to 2 protein entries: FIGN_HUMAN (see all proteins):DKFZp434E0418 DKFZp667C165 VPS4A ATAD1 FIGNL1 FIGNL2
SPAST
FIGN for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FIGN
PGOHUM00000239455
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Genomic Variants
for FIGN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FIGN (164449906 - 164592522 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FIGN
4 CNVs: 4315 78845 6008 90107 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FIGN |
|
Disorders
/ Diseases
for FIGN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FIGN for disorders About GeneDecksing
OMIM gene information: 605295
OMIM disorders: --
2  diseases for FIGN: About MalaCardspolydactyly schizophrenia
Human Genome Epidemiology (HuGE) Navigator: FIGN (5 documents)
Export disorders for FIGN gene to outside databases
|
Publications
for FIGN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FIGN gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with FIGN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development. (PubMed id 11017077)1, 3 Cox G.A....Frankel W.N. (2000)
- Human Fidgetin is a microtubule severing the enzyme an d minus-end depolymerase that regulates mitosis. (PubMed id 22672901)1 Mukherjee S....Sharp D.J. (2012)
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1 Wain L.V....van Duijn C.M. (2011)
- Meta-analysis of genome-wide association studies iden tifies common variants associated with blood pressure variation in east Asians. (PubMed id 21572416)1 Kato N....He J. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
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External Searches for FIGN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FIGN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FIGN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FIGN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FIGN | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FIGN gene:
Search GeneIP for patents involving FIGN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FIGN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FIGN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FIGN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FIGN | | | OriGene Protein Over-expression Lysate for FIGN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FIGN | | OriGene 3'-UTR Clone for FIGN | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIGN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIGN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FIGN | | OriGene Custom Protein Services for FIGN | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FIGN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FIGN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FIGN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FIGN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FIGN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FIGN |
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| | | | Search Tocris compounds for FIGN |
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 | | | FIGN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGN |
|  |  |  | | | | Search ThermoFisher Antibodies for FIGN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGN |
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