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FIGN Gene

protein-coding   GIFtS: 52
GCID: GC02M164430

Fidgetin

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
fidgetin1 2

External Ids:    HGNC: 132851   Entrez Gene: 551372   Ensembl: ENSG000001822637   OMIM: 6052955   UniProtKB: Q5HY923   

Export aliases for FIGN gene to outside databases

Previous GC identifers: GC02M162519 GC02M163005 GC02M164668 GC02M164666 GC02M164289 GC02M164172 GC02M156346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FIGN Gene:
FIGN (fidgetin) is a protein-coding gene. Diseases associated with FIGN include polydactyly, and schizophrenia. GO annotations related to this gene include nucleoside-triphosphatase activity and protein C-terminus binding. An important paralog of this gene is SPAST.

UniProtKB/Swiss-Prot: FIGN_HUMAN, Q5HY92
Function: ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes
their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment
to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the
release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle
poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward
microtubule flux and poleward motion of chromosome




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FIGN gene promoter:
         Max1   USF1   FOXD3   Nkx2-5   SRY   S8   USF-1   Sox9   ZID   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFIGN promoter sequence
   Search Chromatin IP Primers for FIGN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FIGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.3   Ensembl cytogenetic band:  2q24.3   HGNC cytogenetic band: 2q24

FIGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FIGN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M164430:  view genomic region     (about GC identifiers)

Start:
164,449,906 bp from pter      End:
164,592,522 bp from pter
Size:
142,617 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FIGN_HUMAN, Q5HY92 (See protein sequence)
Recommended Name: Fidgetin  
Size: 759 amino acids; 82146 Da
Subunit: Interacts with AKAP8 (via C-terminus) (By similarity)
Sequence caution: Sequence=AAX81992.1; Type=Erroneous gene model prediction; Sequence=BAA91590.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAA91590.1; Type=Frameshift; Positions=71;
Sequence=BAB15231.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KWM0 Q9H6M5 Q9NVZ9

Explore the universe of human proteins at neXtProt for FIGN: NX_Q5HY92

Explore proteomics data for FIGN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FIGN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060556.2  
    ENSEMBL proteins: 
     ENSP00000386768   ENSP00000333836  

    FIGN Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FIGN
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    GenScript Custom Purified and Recombinant Proteins Services for FIGN
    Novus Biologicals FIGN Protein
    Novus Biologicals FIGN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for FIGN

    FIGN Antibody Products:

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    Novus Biologicals FIGN Antibodies
    Abcam antibodies for FIGN
    Cloud-Clone Corp. Antibodies for FIGN
    Search ThermoFisher Antibodies for FIGN
    LSBio Antibodies in human, mouse, rat for FIGN

    FIGN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FIGN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FIGN
    Cloud-Clone Corp. CLIAs for FIGN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type

    4 InterPro protein domains:
     IPR003959 ATPase_AAA_core
     IPR003960 ATPase_AAA_CS
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q5HY92

    ProtoNet protein and cluster: Q5HY92

    1 Blocks protein domain: IPB003960 AAA-protein subdomain

    UniProtKB/Swiss-Prot: FIGN_HUMAN, Q5HY92
    Similarity: Belongs to the AAA ATPase family


    FIGN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FIGN_HUMAN, Q5HY92
    Function: ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes
    their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment
    to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the
    release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle
    poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward
    microtubule flux and poleward motion of chromosome

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:0008022protein C-terminus binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    FIGN for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FIGN:
     Increased mitotic index  Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fign) (see all 19):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  nervous system 

    FIGN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FIGN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FIGN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FIGN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FIGN

    miRNA
    Products:
        
    miRTarBase miRNAs that target FIGN:
    hsa-mir-342-3p (MIRT043667), hsa-mir-21-5p (MIRT030852), hsa-mir-34a-5p (MIRT025427)

    Block miRNA regulation of human, mouse, rat FIGN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FIGN (see all 109):
    hsa-miR-548j hsa-miR-3678-3p hsa-miR-520f hsa-miR-30d hsa-miR-1304 hsa-miR-30a hsa-miR-298 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidFIGN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FIGN
    Predesigned siRNA for gene silencing in human, mouse, rat FIGN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FIGN

    Clone
    Products:
         
    OriGene clones in human, mouse for FIGN (see all 6)
    OriGene ORF clones in mouse, rat for FIGN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FIGN (NM_018086)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FIGN
    Browse ESI BIO Cell Lines and PureStem Progenitors for FIGN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FIGN_HUMAN, Q5HY92: Nucleus matrix (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    cytoskeleton1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0005874microtubule IEA--
    GO:0016363nuclear matrix ISS--

    FIGN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FIGN
    Interactions:

        Search GeneGlobe Interaction Network for FIGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FIGN (ENSP000003338364) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000228532ENSP000003912664STRING: ENSP00000391266
    SMC5ENSP000003549574STRING: ENSP00000354957
    SUMO1ENSP000003760764STRING: ENSP00000376076
    PPP1CAENSP000003260314STRING: ENSP00000326031
    PPP1CBENSP000002961224STRING: ENSP00000296122
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--

    FIGN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FIGN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FIGN gene: 
    NM_018086.2  

    Unigene Cluster for FIGN:

    Fidgetin
    Hs.593650  [show with all ESTs]
    Unigene Representative Sequence: BX649105
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409634 ENST00000333129(uc002uck.1) ENST00000482917

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FIGN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FIGN (see all 109):
    hsa-miR-548j hsa-miR-3678-3p hsa-miR-520f hsa-miR-30d hsa-miR-1304 hsa-miR-30a hsa-miR-298 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidFIGN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FIGN
    Predesigned siRNA for gene silencing in human, mouse, rat FIGN
    Clone
    Products:
         
    OriGene clones in human, mouse for FIGN (see all 6)
    OriGene ORF clones in mouse, rat for FIGN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FIGN (NM_018086)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGN
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FIGN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FIGN
      QuantiTect SYBR Green Assays in human, mouse, rat FIGN
      QuantiFast Probe-based Assays in human, mouse, rat FIGN

    Additional mRNA sequence: 

    AK001267.1 AK025747.1 AK125324.1 BX649105.1 

    1 DOTS entry:

    DT.91657753 

    22 AceView cDNA sequences:

    N20508 AK025747 CK821669 AK001267 NM_018086 BX497903 AK125324 BX649105 
    AU124751 CK821668 BF438393 R00658 CD101939 BM311822 BX501897 BM311232 
    AU148548 BX101827 BF029806 N25413 AI827675 BG877433 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FIGN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAAGCAGA
    FIGN Expression
    About this image


    FIGN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
    FIGN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FIGN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.593650
        Custom PCR Arrays for FIGN
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FIGN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FIGN
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    QuantiFast Probe-based Assays in human, mouse, rat FIGN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FIGN gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fign1 , 5 fidgetin1, 5 92.67(n)1
    97.89(a)1
      2 (37.19 cM)5
    603441  NM_021716.51  NP_068362.11 
     639715075 
    chicken
    (Gallus gallus)
    Aves FIGN1 fidgetin 88.21(n)
    95.38(a)
      429028  XM_004942817.1  XP_004942874.1 
    lizard
    (Anolis carolinensis)
    Reptilia FIGN6
    fidgetin
    94(a)
    1 ↔ 1
    GL343214.1(2614242-2759471)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fign1 fidgetin 81.48(n)
    87.27(a)
      100488151  XM_002933273.2  XP_002933319.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fign1 fidgetin 70.58(n)
    73.67(a)
      553599  NM_001020575.1  NP_001018411.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG33266
    --
    28(a)
    1 → many
    2L(3316794-3319872)
    worm
    (Caenorhabditis elegans)
    Secernentea K04D7.2a3 TAT binding homolog 4 like 31(a)
    (best of 2)
      IV(10178144-10180115)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YTA66
    SAP16
    Putative ATPase of the CDC48/PAS1/SEC18 (AAA) fami...
    Putative ATPase of the AAA family, interacts with ...
    19(a)
    19(a)
    many ↔ many
    many ↔ many
    XVI(415763-418027) YPL074W
    V(243810-246503) YER047C


    ENSEMBL Gene Tree for FIGN (if available)
    TreeFam Gene Tree for FIGN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FIGN gene
    SPAST2  IQCA12  FIGNL12  
    7 SIMAP similar genes for FIGN using alignment to 2 protein entries:     FIGN_HUMAN (see all proteins):
    DKFZp434E0418    DKFZp667C165    VPS4A    ATAD1    FIGNL1    FIGNL2
    SPAST

    FIGN for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FIGN
    PGOHUM00000239455


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FIGN (see all 2318)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104273791,2
    C,H--164463809(+) ACTTGC/TGAAAA 1 -- ds50014Minor allele frequency- T:0.00NS EA 418
    rs118916871,2
    H--164463896(+) TAAGCA/CCAGCT 1 -- ds50010--------
    rs1832869621,2
    C--164463946(+) AATTGA/CTCAGT 1 -- ds50010--------
    rs1439638821,2
    --164463999(+) GCATCA/GTAAAA 1 -- ds50010--------
    rs2007845341,2
    C--164464039(+) TTTCT-/TATGT 
            
    ATGTT
    1 -- ds50010--------
    rs75835271,2
    C,F,H--164464056(+) TTCAGA/GGAATT 1 -- ds500130Minor allele frequency- N:0.00EA NA NS WA 2974
    rs1879294841,2
    --164464071(+) ATTGTC/GGATAA 1 -- ds50010--------
    rs2011179001,2
    --164464098(+) GTAAG-/AAAAAA 1 -- ds50010--------
    rs1906238241,2
    --164464103(+) GAAAAA/CAAAAA 1 -- ds50010--------
    rs1832947491,2
    --164464157(+) TTTTTA/TAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FIGN (164449906 - 164592522 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FIGN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270876CNV Insertion20981092
    nsv213604CNV Loss16902084
    nsv834442CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FIGN
    DNA2.0 Custom Variant and Variant Library Synthesis for FIGN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605295    OMIM disorders: --

    2 diseases for FIGN:    
    About MalaCards
    polydactyly    schizophrenia


    FIGN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): FIGN
    Human Genome Epidemiology (HuGE) Navigator: FIGN (5 documents)

    Export disorders for FIGN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FIGN gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with FIGN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis. (PubMed id 22672901)1, 2 Mukherjee S....Sharp D.J. (Cell Cycle 2012)
    2. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
    3. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PubMed id 21572416)1, 4 Kato N....He J. (Nat. Genet. 2011)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients. (PubMed id 19680635)1, 4 Alkelai A....Lerer B. (Psychopharmacology (Berl.) 2009)
    6. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development. (PubMed id 11017077)1, 3 Cox G.A....Frankel W.N. (Nat. Genet. 2000)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55137 HGNC: 13285 AceView: FIGN Ensembl:ENSG00000182263 euGenes: HUgn55137
    ECgene: FIGN H-InvDB: FIGN

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FIGN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for FIGN gene:
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