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Aliases for FIGN Gene

Aliases for FIGN Gene

  • Fidgetin, Microtubule Severing Factor 2 3 5
  • Fidgetin 2 3

External Ids for FIGN Gene

Previous GeneCards Identifiers for FIGN Gene

  • GC02M162519
  • GC02M163005
  • GC02M164430
  • GC02M164668
  • GC02M164666
  • GC02M164289
  • GC02M164172
  • GC02M156346

Summaries for FIGN Gene

GeneCards Summary for FIGN Gene

FIGN (Fidgetin, Microtubule Severing Factor) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding and microtubule-severing ATPase activity. An important paralog of this gene is FIGNL2.

UniProtKB/Swiss-Prot for FIGN Gene

  • ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIGN Gene

Genomics for FIGN Gene

Regulatory Elements for FIGN Gene

Enhancers for FIGN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G163709 1.7 dbSUPER 13.7 +25.0 24983 2.9 FOXA2 TAF1 CEBPG YY1 NR2F2 FOXA1 GATA3 HNF1A CEBPA NR2F6 FIGN GC02P163605
GH02G163665 1.2 Ensembl ENCODE 11.4 +69.0 68967 2.7 ELF3 PKNOX1 FOXA2 NFIB DNMT3B ZSCAN9 RAD21 RARA GATA2 RCOR1 FIGN GC02P163605
GH02G163712 0.7 dbSUPER 17 +21.5 21527 3.5 RAD21 YY1 RARA ZNF600 PRDM10 NR2F6 ZNF652 GATAD2A ZNF10 FOXA3 FIGN GC02P163605
GH02G163680 0.7 dbSUPER 16.5 +54.0 53980 3.5 ELF3 CTCF FOXA2 JUN CEBPG RAD21 GATA3 SMC3 FOSL2 PRDM10 FIGN GC02P163605
GH02G163717 2.2 VISTA dbSUPER 4.4 +18.0 17975 1.5 SOX5 SOX13 GATAD2A CTCF ZNF362 FOXA2 FOXA3 CEBPB EP300 RAD21 FIGN GC02P163605
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FIGN on UCSC Golden Path with GeneCards custom track

Promoters for FIGN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000125569 1097 4601 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ZNF121 GLIS2

Genomic Location for FIGN Gene

Chromosome:
2
Start:
163,593,396 bp from pter
End:
163,736,197 bp from pter
Size:
142,802 bases
Orientation:
Minus strand

Genomic View for FIGN Gene

Genes around FIGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIGN Gene

Proteins for FIGN Gene

  • Protein details for FIGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HY92-FIGN_HUMAN
    Recommended name:
    Fidgetin
    Protein Accession:
    Q5HY92
    Secondary Accessions:
    • B3KWM0
    • Q9H6M5
    • Q9NVZ9

    Protein attributes for FIGN Gene

    Size:
    759 amino acids
    Molecular mass:
    82146 Da
    Quaternary structure:
    • Interacts with AKAP8 (via C-terminus).
    SequenceCaution:
    • Sequence=AAX81992.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91590.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91590.1; Type=Frameshift; Positions=71; Evidence={ECO:0000305}; Sequence=BAB15231.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FIGN Gene

Post-translational modifications for FIGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FIGN Gene

No data available for DME Specific Peptides for FIGN Gene

Domains & Families for FIGN Gene

Gene Families for FIGN Gene

Protein Domains for FIGN Gene

Suggested Antigen Peptide Sequences for FIGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HY92

UniProtKB/Swiss-Prot:

FIGN_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with FIGN: view

Function for FIGN Gene

Molecular function for FIGN Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.

Gene Ontology (GO) - Molecular Function for FIGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008022 protein C-terminus binding IEA --
GO:0008568 microtubule-severing ATPase activity IBA --
genes like me logo Genes that share ontologies with FIGN: view
genes like me logo Genes that share phenotypes with FIGN: view

Animal Models for FIGN Gene

MGI Knock Outs for FIGN:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FIGN Gene

Localization for FIGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIGN Gene

Nucleus matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIGN gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for FIGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with FIGN: view

Pathways & Interactions for FIGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0010569 regulation of double-strand break repair via homologous recombination IBA --
GO:0031122 cytoplasmic microtubule organization IBA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with FIGN: view

No data available for Pathways by source and SIGNOR curated interactions for FIGN Gene

Drugs & Compounds for FIGN Gene

No Compound Related Data Available

Transcripts for FIGN Gene

Unigene Clusters for FIGN Gene

Fidgetin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIGN Gene

No ASD Table

Relevant External Links for FIGN Gene

GeneLoc Exon Structure for
FIGN
ECgene alternative splicing isoforms for
FIGN

Expression for FIGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FIGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FIGN Gene

This gene is overexpressed in Nerve - Tibial (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FIGN Gene



NURSA nuclear receptor signaling pathways regulating expression of FIGN Gene:

FIGN

SOURCE GeneReport for Unigene cluster for FIGN Gene:

Hs.593650
genes like me logo Genes that share expression patterns with FIGN: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FIGN Gene

Orthologs for FIGN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FIGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIGN 34 35
  • 99.78 (n)
oppossum
(Monodelphis domestica)
Mammalia FIGN 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FIGN 34 35
  • 94.91 (n)
rat
(Rattus norvegicus)
Mammalia Fign 34
  • 92.84 (n)
mouse
(Mus musculus)
Mammalia Fign 34 16 35
  • 92.67 (n)
dog
(Canis familiaris)
Mammalia FIGN 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FIGN 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FIGN 34 35
  • 88.21 (n)
lizard
(Anolis carolinensis)
Reptilia FIGN 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fign 34
  • 81.48 (n)
zebrafish
(Danio rerio)
Actinopterygii fign 34 35
  • 70.58 (n)
BX005368.2 35
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3326 35
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K04D7.2a 36
  • 31 (a)
K04D7.2b 36
  • 31 (a)
figl-1 35
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAP1 35
  • 19 (a)
ManyToMany
YTA6 35
  • 19 (a)
ManyToMany
Species where no ortholog for FIGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FIGN Gene

ENSEMBL:
Gene Tree for FIGN (if available)
TreeFam:
Gene Tree for FIGN (if available)

Paralogs for FIGN Gene

Paralogs for FIGN Gene

(7) SIMAP similar genes for FIGN Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FIGN Gene

genes like me logo Genes that share paralogs with FIGN: view

Variants for FIGN Gene

Sequence variations from dbSNP and Humsavar for FIGN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000004693 -- 163,617,614(+) ATAGA(C/T)TGTTG intron-variant, utr-variant-5-prime
rs1000050880 -- 163,629,868(+) ATTGA(C/T)GGAAC intron-variant
rs1000084401 -- 163,621,670(+) TAGAC(A/C)TGAGC intron-variant, utr-variant-5-prime
rs1000111852 -- 163,623,184(+) CTGTT(A/T)TTATC intron-variant, upstream-variant-2KB
rs1000117704 -- 163,631,171(+) TGGTT(A/T)CACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FIGN Gene

Variant ID Type Subtype PubMed ID
esv3444904 CNV insertion 20981092
nsv1109307 CNV deletion 24896259
nsv1123404 CNV deletion 24896259
nsv1123405 CNV deletion 24896259
nsv1160879 CNV deletion 26073780
nsv213604 CNV deletion 16902084
nsv834442 CNV gain 17160897

Variation tolerance for FIGN Gene

Residual Variation Intolerance Score: 4.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIGN Gene

Disorders for FIGN Gene

Relevant External Links for FIGN

Genetic Association Database (GAD)
FIGN
Human Genome Epidemiology (HuGE) Navigator
FIGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FIGN

No disorders were found for FIGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIGN Gene

Publications for FIGN Gene

  1. Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis. (PMID: 22672901) Mukherjee S. … Sharp D.J. (Cell Cycle 2012) 3 4 64
  2. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 3 46 64
  3. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PMID: 21572416) Kato N. … He J. (Nat. Genet. 2011) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64

Products for FIGN Gene

Sources for FIGN Gene

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