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Aliases for FIGN Gene

Aliases for FIGN Gene

  • Fidgetin, Microtubule Severing Factor 2 3 5
  • Fidgetin 2 3

External Ids for FIGN Gene

Previous GeneCards Identifiers for FIGN Gene

  • GC02M162519
  • GC02M163005
  • GC02M164430
  • GC02M164668
  • GC02M164666
  • GC02M164289
  • GC02M164172
  • GC02M156346

Summaries for FIGN Gene

GeneCards Summary for FIGN Gene

FIGN (Fidgetin, Microtubule Severing Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding and microtubule-severing ATPase activity. An important paralog of this gene is FIGNL2.

UniProtKB/Swiss-Prot for FIGN Gene

  • ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.

Additional gene information for FIGN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIGN Gene

Genomics for FIGN Gene

GeneHancer (GH) Regulatory Elements for FIGN Gene

Promoters and enhancers for FIGN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I163732 Promoter/Enhancer 2.6 UCNEbase EPDnew Ensembl ENCODE dbSUPER 550.8 +1.0 951 5 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ETS1 YY1 ZNF121 FIGN GC02P163605
GH02I163665 Enhancer 1.1 Ensembl ENCODE 11.5 +69.0 68966 2.7 ELF3 FOXA2 DNMT3B ZSCAN9 RAD21 RARA ETS1 SMARCC2 FOS RCOR1 FIGN GC02P163605
GH02I163713 Enhancer 0.7 dbSUPER 17 +21.5 21527 3.5 RXRA ZNF189 ZNF10 MZF1 OVOL3 RAD21 YY1 ZFP69B ZNF335 PRDM6 FIGN GC02P163605
GH02I163680 Enhancer 0.5 dbSUPER 16.5 +54.0 53979 3.5 GATAD2A CTCF FOXA2 JUN PRDM10 FOSL2 FOS FIGN GC02P163605
GH02I163711 Enhancer 0.6 UCNEbase dbSUPER 13.7 +24.8 24788 0.5 FIGN GC02P163605
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FIGN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FIGN gene promoter:

Genomic Locations for FIGN Gene

Genomic Locations for FIGN Gene
chr2:163,593,396-163,736,197
(GRCh38/hg38)
Size:
142,802 bases
Orientation:
Minus strand
chr2:164,449,906-164,592,522
(GRCh37/hg19)

Genomic View for FIGN Gene

Genes around FIGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIGN Gene

Proteins for FIGN Gene

  • Protein details for FIGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HY92-FIGN_HUMAN
    Recommended name:
    Fidgetin
    Protein Accession:
    Q5HY92
    Secondary Accessions:
    • B3KWM0
    • Q9H6M5
    • Q9NVZ9

    Protein attributes for FIGN Gene

    Size:
    759 amino acids
    Molecular mass:
    82146 Da
    Quaternary structure:
    • Interacts with AKAP8 (via C-terminus).
    SequenceCaution:
    • Sequence=AAX81992.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91590.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91590.1; Type=Frameshift; Positions=71; Evidence={ECO:0000305}; Sequence=BAB15231.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FIGN Gene

Post-translational modifications for FIGN Gene

No Post-translational modifications

Other Protein References for FIGN Gene

Antibody Products

No data available for DME Specific Peptides for FIGN Gene

Domains & Families for FIGN Gene

Gene Families for FIGN Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FIGN Gene

Suggested Antigen Peptide Sequences for FIGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HY92

UniProtKB/Swiss-Prot:

FIGN_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with FIGN: view

Function for FIGN Gene

Molecular function for FIGN Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.

Phenotypes From GWAS Catalog for FIGN Gene

Gene Ontology (GO) - Molecular Function for FIGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008022 protein C-terminus binding IEA --
GO:0016887 contributes_to ATPase activity IBA --
genes like me logo Genes that share ontologies with FIGN: view
genes like me logo Genes that share phenotypes with FIGN: view

Animal Models for FIGN Gene

MGI Knock Outs for FIGN:

Animal Model Products

CRISPR Products

miRNA for FIGN Gene

miRTarBase miRNAs that target FIGN

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FIGN Gene

Localization for FIGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIGN Gene

Nucleus matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIGN gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
plasma membrane 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FIGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with FIGN: view

Pathways & Interactions for FIGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0010569 regulation of double-strand break repair via homologous recombination IBA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with FIGN: view

No data available for Pathways by source and SIGNOR curated interactions for FIGN Gene

Drugs & Compounds for FIGN Gene

No Compound Related Data Available

Transcripts for FIGN Gene

Unigene Clusters for FIGN Gene

Fidgetin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIGN Gene

No ASD Table

Relevant External Links for FIGN Gene

GeneLoc Exon Structure for
FIGN
ECgene alternative splicing isoforms for
FIGN

Expression for FIGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FIGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FIGN Gene

This gene is overexpressed in Nerve - Tibial (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FIGN Gene



NURSA nuclear receptor signaling pathways regulating expression of FIGN Gene:

FIGN

SOURCE GeneReport for Unigene cluster for FIGN Gene:

Hs.593650
genes like me logo Genes that share expression patterns with FIGN: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FIGN Gene

Orthologs for FIGN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FIGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIGN 33 34
  • 99.78 (n)
oppossum
(Monodelphis domestica)
Mammalia FIGN 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FIGN 33 34
  • 94.91 (n)
rat
(Rattus norvegicus)
Mammalia Fign 33
  • 92.84 (n)
mouse
(Mus musculus)
Mammalia Fign 33 16 34
  • 92.67 (n)
dog
(Canis familiaris)
Mammalia FIGN 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FIGN 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FIGN 33 34
  • 88.21 (n)
lizard
(Anolis carolinensis)
Reptilia FIGN 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fign 33
  • 81.48 (n)
zebrafish
(Danio rerio)
Actinopterygii fign 33 34
  • 70.58 (n)
BX005368.2 34
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3326 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K04D7.2a 35
  • 31 (a)
K04D7.2b 35
  • 31 (a)
figl-1 34
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAP1 34
  • 19 (a)
ManyToMany
YTA6 34
  • 19 (a)
ManyToMany
Species where no ortholog for FIGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FIGN Gene

ENSEMBL:
Gene Tree for FIGN (if available)
TreeFam:
Gene Tree for FIGN (if available)

Paralogs for FIGN Gene

Paralogs for FIGN Gene

(7) SIMAP similar genes for FIGN Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FIGN Gene

genes like me logo Genes that share paralogs with FIGN: view

Variants for FIGN Gene

Sequence variations from dbSNP and Humsavar for FIGN Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000004693 -- 163,617,614(-) T/C 5_prime_UTR_variant, intron_variant
rs1000050880 -- 163,629,868(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000084401 -- 163,621,670(-) C/A 5_prime_UTR_variant, intron_variant
rs1000111852 -- 163,623,184(-) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000117704 -- 163,631,171(-) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FIGN Gene

Variant ID Type Subtype PubMed ID
esv3444904 CNV insertion 20981092
nsv1109307 CNV deletion 24896259
nsv1123404 CNV deletion 24896259
nsv1123405 CNV deletion 24896259
nsv1160879 CNV deletion 26073780
nsv213604 CNV deletion 16902084
nsv834442 CNV gain 17160897

Variation tolerance for FIGN Gene

Residual Variation Intolerance Score: 4.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FIGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIGN Gene

Disorders for FIGN Gene

Additional Disease Information for FIGN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FIGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIGN Gene

Publications for FIGN Gene

  1. Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis. (PMID: 22672901) Mukherjee S … Sharp DJ (Cell cycle (Georgetown, Tex.) 2012) 3 4 58
  2. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PMID: 21572416) Kato N … He J (Nature genetics 2011) 3 44 58
  3. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain LV … van Duijn CM (Nature genetics 2011) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58

Products for FIGN Gene

Sources for FIGN Gene

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