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Aliases for FIGN Gene

Aliases for FIGN Gene

  • Fidgetin 2 3 5

External Ids for FIGN Gene

Previous GeneCards Identifiers for FIGN Gene

  • GC02M162519
  • GC02M163005
  • GC02M164430
  • GC02M164668
  • GC02M164666
  • GC02M164289
  • GC02M164172
  • GC02M156346

Summaries for FIGN Gene

GeneCards Summary for FIGN Gene

FIGN (Fidgetin) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding and microtubule-severing ATPase activity. An important paralog of this gene is IQCA1L.

UniProtKB/Swiss-Prot for FIGN Gene

  • ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIGN Gene

Genomics for FIGN Gene

Regulatory Elements for FIGN Gene

Promoters for FIGN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FIGN on UCSC Golden Path with GeneCards custom track

Genomic Location for FIGN Gene

Chromosome:
2
Start:
163,593,396 bp from pter
End:
163,736,197 bp from pter
Size:
142,802 bases
Orientation:
Minus strand

Genomic View for FIGN Gene

Genes around FIGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIGN Gene

Proteins for FIGN Gene

  • Protein details for FIGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HY92-FIGN_HUMAN
    Recommended name:
    Fidgetin
    Protein Accession:
    Q5HY92
    Secondary Accessions:
    • B3KWM0
    • Q9H6M5
    • Q9NVZ9

    Protein attributes for FIGN Gene

    Size:
    759 amino acids
    Molecular mass:
    82146 Da
    Quaternary structure:
    • Interacts with AKAP8 (via C-terminus).
    SequenceCaution:
    • Sequence=AAX81992.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91590.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91590.1; Type=Frameshift; Positions=71; Evidence={ECO:0000305}; Sequence=BAB15231.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FIGN Gene

Proteomics data for FIGN Gene at MOPED

Post-translational modifications for FIGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FIGN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FIGN Gene

Domains & Families for FIGN Gene

Gene Families for FIGN Gene

Protein Domains for FIGN Gene

Suggested Antigen Peptide Sequences for FIGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HY92

UniProtKB/Swiss-Prot:

FIGN_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with FIGN: view

Function for FIGN Gene

Molecular function for FIGN Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.
genes like me logo Genes that share phenotypes with FIGN: view

Animal Models for FIGN Gene

MGI Knock Outs for FIGN:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FIGN Gene

Localization for FIGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIGN Gene

Nucleus matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FIGN Gene COMPARTMENTS Subcellular localization image for FIGN gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for FIGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with FIGN: view

Pathways & Interactions for FIGN Gene

SuperPathways for FIGN Gene

No Data Available

Interacting Proteins for FIGN Gene

Gene Ontology (GO) - Biological Process for FIGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010569 regulation of double-strand break repair via homologous recombination IBA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with FIGN: view

No data available for Pathways by source and SIGNOR curated interactions for FIGN Gene

Drugs & Compounds for FIGN Gene

No Compound Related Data Available

Transcripts for FIGN Gene

Unigene Clusters for FIGN Gene

Fidgetin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FIGN Gene

No ASD Table

Relevant External Links for FIGN Gene

GeneLoc Exon Structure for
FIGN
ECgene alternative splicing isoforms for
FIGN

Expression for FIGN Gene

mRNA expression in normal human tissues for FIGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FIGN Gene

This gene is overexpressed in Nerve - Tibial (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FIGN Gene



SOURCE GeneReport for Unigene cluster for FIGN Gene Hs.593650

genes like me logo Genes that share expression patterns with FIGN: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FIGN Gene

Orthologs for FIGN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FIGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIGN 35
  • 99.78 (n)
  • 100 (a)
FIGN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FIGN 36
  • 98 (a)
OneToOne
FIGN 35
  • 94.91 (n)
  • 98.55 (a)
dog
(Canis familiaris)
Mammalia FIGN 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fign 16
Fign 35
  • 92.67 (n)
  • 97.89 (a)
Fign 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FIGN 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FIGN 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fign 35
  • 92.84 (n)
  • 98.16 (a)
chicken
(Gallus gallus)
Aves FIGN 36
  • 96 (a)
OneToOne
FIGN 35
  • 88.21 (n)
  • 95.38 (a)
lizard
(Anolis carolinensis)
Reptilia FIGN 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fign 35
  • 81.48 (n)
  • 87.27 (a)
zebrafish
(Danio rerio)
Actinopterygii BX005368.2 36
  • 41 (a)
OneToMany
fign 36
  • 74 (a)
OneToMany
fign 35
  • 70.58 (n)
  • 73.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3326 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K04D7.2a 37
  • 31 (a)
K04D7.2b 37
  • 31 (a)
figl-1 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAP1 36
  • 19 (a)
ManyToMany
YTA6 36
  • 19 (a)
ManyToMany
Species with no ortholog for FIGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FIGN Gene

ENSEMBL:
Gene Tree for FIGN (if available)
TreeFam:
Gene Tree for FIGN (if available)

Paralogs for FIGN Gene

Paralogs for FIGN Gene

(7) SIMAP similar genes for FIGN Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FIGN Gene

genes like me logo Genes that share paralogs with FIGN: view

Variants for FIGN Gene

Sequence variations from dbSNP and Humsavar for FIGN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2231902 - 163,611,545(-) ACCAT(C/T)AGGAC reference, missense
rs2231904 - 163,610,490(-) GACTC(C/T)GTGCA reference, missense
rs2231905 - 163,610,138(-) AGAGA(A/G)AATTA reference, missense
rs728699 -- 163,721,002(-) CCTTC(C/T)CTTTC intron-variant
rs883208 -- 163,656,108(-) GGGGA(G/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FIGN Gene

Variant ID Type Subtype PubMed ID
nsv834442 CNV Gain 17160897
esv270876 CNV Insertion 20981092
nsv213604 CNV Loss 16902084

Variation tolerance for FIGN Gene

Residual Variation Intolerance Score: 4.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIGN Gene

HapMap Linkage Disequilibrium report
FIGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIGN Gene

Disorders for FIGN Gene

Relevant External Links for FIGN

Genetic Association Database (GAD)
FIGN
Human Genome Epidemiology (HuGE) Navigator
FIGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FIGN

No disorders were found for FIGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIGN Gene

Publications for FIGN Gene

  1. Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis. (PMID: 22672901) Mukherjee S. … Sharp D.J. (Cell Cycle 2012) 3 4 67
  2. The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development. (PMID: 11017077) Cox G.A. … Frankel W.N. (Nat. Genet. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. (PMID: 24954895) Simino J. … Rao D.C. (Am. J. Hum. Genet. 2014) 3
  5. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 3

Products for FIGN Gene

Sources for FIGN Gene

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