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Aliases for FIGLA Gene

Aliases for FIGLA Gene

  • Folliculogenesis Specific Basic Helix-Loop-Helix 2 3
  • Folliculogenesis-Specific Basic Helix-Loop-Helix Protein 3 4
  • Class C Basic Helix-Loop-Helix Protein 8 3 4
  • Factor In The Germline Alpha 2 3
  • Transcription Factor FIGa 3 4
  • FIGALPHA 3 4
  • BHLHC8 3 4
  • POF6 3 6

External Ids for FIGLA Gene

Summaries for FIGLA Gene

Entrez Gene Summary for FIGLA Gene

  • This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]

GeneCards Summary for FIGLA Gene

FIGLA (Folliculogenesis Specific Basic Helix-Loop-Helix) is a Protein Coding gene. Diseases associated with FIGLA include premature ovarian failure 6 and premature ovarian failure. GO annotations related to this gene include sequence-specific DNA binding and protein dimerization activity.

UniProtKB/Swiss-Prot for FIGLA Gene

  • Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5-CANNTG-3) of the ZPs (ZP1, ZP2, ZP3) promoters.

Gene Wiki entry for FIGLA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIGLA Gene

Genomics for FIGLA Gene

Genomic Location for FIGLA Gene

Start:
70,777,310 bp from pter
End:
70,790,643 bp from pter
Size:
13,334 bases
Orientation:
Minus strand

Genomic View for FIGLA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FIGLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIGLA Gene

Proteins for FIGLA Gene

  • Protein details for FIGLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6QHK4-FIGLA_HUMAN
    Recommended name:
    Factor in the germline alpha
    Protein Accession:
    Q6QHK4
    Secondary Accessions:

    Protein attributes for FIGLA Gene

    Size:
    219 amino acids
    Molecular mass:
    24123 Da
    Quaternary structure:
    • Heterodimer with TCF3/isoform E12

neXtProt entry for FIGLA Gene

Proteomics data for FIGLA Gene at MOPED

Post-translational modifications for FIGLA Gene

No Post-translational modifications

Other Protein References for FIGLA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FIGLA Gene

Domains for FIGLA Gene

Gene Families for FIGLA Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for FIGLA Gene

UniProtKB/Swiss-Prot:

FIGLA_HUMAN
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q6QHK4
genes like me logo Genes that share domains with FIGLA: view

Function for FIGLA Gene

Molecular function for FIGLA Gene

UniProtKB/Swiss-Prot Function: Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5-CANNTG-3) of the ZPs (ZP1, ZP2, ZP3) promoters.

Gene Ontology (GO) - Molecular Function for FIGLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IPI 15044608
GO:0043565 contributes_to sequence-specific DNA binding IDA 15044608
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with FIGLA: view

Phenotypes for FIGLA Gene

genes like me logo Genes that share phenotypes with FIGLA: view

Animal Models for FIGLA Gene

MGI Knock Outs for FIGLA:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FIGLA Gene

Localization for FIGLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIGLA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FIGLA Gene COMPARTMENTS Subcellular localization image for FIGLA gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FIGLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IDA 15044608
genes like me logo Genes that share ontologies with FIGLA: view

Pathways for FIGLA Gene

SuperPathways for FIGLA Gene

No Data Available

Interacting Proteins for FIGLA Gene

Gene Ontology (GO) - Biological Process for FIGLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0048599 oocyte development NAS 15044608
genes like me logo Genes that share ontologies with FIGLA: view

No data available for Pathways by source for FIGLA Gene

Transcripts for FIGLA Gene

mRNA/cDNA for FIGLA Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FIGLA Gene

Folliculogenesis specific basic helix-loop-helix:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FIGLA Gene

No ASD Table

Relevant External Links for FIGLA Gene

GeneLoc Exon Structure for
FIGLA
ECgene alternative splicing isoforms for
FIGLA

Expression for FIGLA Gene

mRNA expression in normal human tissues for FIGLA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FIGLA Gene

This gene is overexpressed in Ovary (7.8), Pancreas (7.7), and Testis (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FIGLA Gene

SOURCE GeneReport for Unigene cluster for FIGLA Gene Hs.407636

mRNA Expression by UniProt/SwissProt for FIGLA Gene

Q6QHK4-FIGLA_HUMAN
Tissue specificity: Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid-gestation, rising some 40-fold by the time of primordial follicle formation.
genes like me logo Genes that share expressions with FIGLA: view

Orthologs for FIGLA Gene

This gene was present in the common ancestor of chordates.

Orthologs for FIGLA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIGLA 36
  • 99.24 (n)
  • 98.17 (a)
FIGLA 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FIGLA 36
  • 84.17 (n)
  • 77.65 (a)
FIGLA 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FIGLA 36
  • 79.87 (n)
  • 74 (a)
FIGLA 37
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Figla 36
  • 74.47 (n)
  • 68.62 (a)
Figla 16
Figla 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FIGLA 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Figla 36
  • 76.08 (n)
  • 72.35 (a)
zebrafish
(Danio rerio)
Actinopterygii figla 37
  • 20 (a)
OneToMany
figla 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 17 (a)
OneToOne
Species with no ortholog for FIGLA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FIGLA Gene

ENSEMBL:
Gene Tree for FIGLA (if available)
TreeFam:
Gene Tree for FIGLA (if available)

Paralogs for FIGLA Gene

Pseudogenes.org Pseudogenes for FIGLA Gene

genes like me logo Genes that share paralogs with FIGLA: view

No data available for Paralogs for FIGLA Gene

Variants for FIGLA Gene

Sequence variations from dbSNP and Humsavar for FIGLA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2024454 -- 70,779,257(+) TTAAA(A/C/T)GGGAA intron-variant
rs2024455 -- 70,779,700(+) TGTAA(C/T)AGATA intron-variant
rs2024456 -- 70,779,922(+) GAACA(C/G)CCTGC intron-variant
rs2024457 -- 70,780,262(+) CCCTG(A/C)CACTA intron-variant
rs2080393 -- 70,782,171(+) aaaga(A/G)aaaga intron-variant

Relevant External Links for FIGLA Gene

HapMap Linkage Disequilibrium report
FIGLA
Human Gene Mutation Database (HGMD)
FIGLA

No data available for Structural Variations from Database of Genomic Variants (DGV) for FIGLA Gene

Disorders for FIGLA Gene

(1) OMIM Diseases for FIGLA Gene (608697)

UniProtKB/Swiss-Prot

FIGLA_HUMAN
  • Premature ovarian failure 6 (POF6) [MIM:612310]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. {ECO:0000269 PubMed:18499083}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for FIGLA Gene

genes like me logo Genes that share disorders with FIGLA: view

Publications for FIGLA Gene

  1. Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes. (PMID: 12468641) Huntriss J. … Picton H.M. (Mol. Hum. Reprod. 2002) 2 3 4 23
  2. Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary. (PMID: 15044608) Bayne R.A.L. … Anderson R.A. (Mol. Hum. Reprod. 2004) 3 4 23
  3. Zona pellucida components are present in human fetal ovary before follicle formation. (PMID: 18502569) TAPrmAolAo R.M. … Vaskivuo T.E. (Mol. Cell. Endocrinol. 2008) 3 23
  4. Transcription factor FIGLA is mutated in patients with premature ovarian failure. (PMID: 18499083) Zhao H. … Rajkovic A. (Am. J. Hum. Genet. 2008) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FIGLA Gene

Sources for FIGLA Gene

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