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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FIGLA Gene

protein-coding   GIFtS: 44
GCID: GC02M071004

folliculogenesis specific basic helix-loop-helix
 Explore 3 diseases affiliated with
FIGLA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FIGLA    

Aliases
for FIGLA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Folliculogenesis Specific Basic Helix-Loop-Helix1 2     BHLHC82 3
BHLHc81     POF62 5
Class C Basic Helix-Loop-Helix Protein 82 3     FIGALPHA2
Folliculogenesis-Specific Basic Helix-Loop-Helix Protein2 3     Factor In The Germline Alpha2
Transcription Factor FIGa2 3     FIGalpha3

External Ids:    HGNC: 246691   Entrez Gene: 3440182   Ensembl: ENSG000001837337   OMIM: 6086975   UniProtKB: Q6QHK43   

Export aliases for FIGLA gene to outside databases

Previous GC identifers: GC02M070962 GC02U900441 GC02M070916 GC02M070847 GC02M070741


Summaries
for FIGLA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FIGLA:
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic
helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in
folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type
6. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: FIGLA_HUMAN, Q6QHK4
Function: Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key
regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis
and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival.
Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests
that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box
(5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters

Gene Wiki entry for FIGLA


Genomic Views
for FIGLA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FIGLA gene promoter:
         AML1a   NF-kappaB   c-Ets-1   PPAR-gamma1   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FIGLA promoter sequence
   Search SABiosciences Chromatin IP Primers for FIGLA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FIGLA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.3

FIGLA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FIGLA gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M071004:  view genomic region     (about GC identifiers)

Start:
 71,004,442 bp from pter      End:
 71,017,775 bp from pter
Size:
 13,334 bases      Orientation:
 minus strand

Proteins
for FIGLA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FIGLA_HUMAN, Q6QHK4 (See protein sequence)
Recommended Name: Factor in the germline alpha  
Size: 219 amino acids; 24123 Da
Subunit: Heterodimer with TCF3/isoform E12
Subcellular location: Nucleus (Probable)
Developmental stage: Expressed in ovarian follicles (from the primordial through to the secondary stage), in mature
oocytes, and less frequently in preimplantation embryos

Explore the universe of human proteins at neXtProt for FIGLA: NX_Q6QHK4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6QHK4

    • FIGLA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001004311.2  
    ENSEMBL proteins: 
     ENSP00000333097  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: FIGLA
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for FIGLA 
    GenScript Custom Purified and Recombinant Proteins Services for FIGLA
    Novus Biologicals FIGLA Proteins
    Novus Biologicals FIGLA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005667transcription factor complex IDA15044608


    FIGLA for ontologies           About GeneDecksing



    FIGLA Antibody Products: 
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    Search for Antibodies for FIGLA at Abcam  
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    Search ThermoFisher Antibodies for FIGLA

    Assay Products for FIGLA: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for FIGLA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FIGLA for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q6QHK4

    ProtoNet protein and cluster: Q6QHK4

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: FIGLA_HUMAN, Q6QHK4
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for FIGLA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FIGLA_HUMAN, Q6QHK4
    Function: Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key
    regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis
    and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival.
    Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests
    that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box
    (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FIGLA
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FIGLA
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FIGLA (see all 4)
    OriGene shRNA RFP: FIGLA
    OriGene siRNA: FIGLA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FIGLA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FIGLA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIGLA (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIGLA
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FIGLA (NM_001004311)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIGLA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGLA 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FIGLA
    Search LifeMap BioReagents cell lines for FIGLA

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FIGLA

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008134transcription factor binding IPI15044608
    GO:0043565contributes to sequence-specific DNA binding IDA15044608
    GO:0046983protein dimerization activity IEA--


    FIGLA for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Figlatm1Dean for FIGLA
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Figla):
     endocrine/exocrine gland  reproductive system 

    FIGLA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FIGLA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FIGLA

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0048599oocyte development NAS15044608


    FIGLA for ontologies           About GeneDecksing



    Drugs & Compounds
    for FIGLA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FIGLA
    Search CenterWatch for drugs/clinical trials and news about FIGLA 

    Transcripts
    for FIGLA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FIGLA gene: 
    NM_001004311.3  

    Unigene Cluster for FIGLA:

    Folliculogenesis specific basic helix-loop-helix
    Hs.407636
    Unigene Representative Sequence: AY541030
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000332372(uc002she.1)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FIGLA
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FIGLA
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FIGLA (see all 4)
    OriGene shRNA RFP: FIGLA
    OriGene siRNA: FIGLA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FIGLA
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIGLA (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIGLA
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FIGLA (NM_001004311)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIGLA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGLA 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FIGLA
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FIGLA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FIGLA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FIGLA

    Additional cDNA sequence: 

    AY541030.1 BC039536.1 

    1 DOTS entry:

    DT.97771949 

    4 AceView cDNA sequences:

    BC039536 AY541030 NM_001004311 BM560361 

    GeneLoc Exon Structure


    Expression
    for FIGLA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FIGLA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACCCCGCGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FIGLA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    OvaryOvigerous CordXX Germ CellsFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FIGLA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FIGLA

    SOURCE GeneReport for Unigene cluster: Hs.407636

    UniProtKB/Swiss-Prot: FIGLA_HUMAN, Q6QHK4
    Tissue specificity: Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases
    across mid-gestation, rising some 40-fold by the time of primordial follicle formation

        SABiosciences Custom PCR Arrays for FIGLA
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FIGLA
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FIGLA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FIGLA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FIGLA
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FIGLA

    Orthologs
    for FIGLA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FIGLA gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Figla1 , 5 folliculogenesis specific basic helix-loop-helix1, 5 74.47(n)1
    68.62(a)1    		   6 (37.55 cM)5
    269101  NM_012013.11  NP_036143.11 
     860171915 
    zebrafish
    (Danio rerio)    		 Actinopterygii figla6
    FP016061.16
    		 --
    		 28(a)
    28(a)
    		 many → 1
    many → 1
    		 5(15047466-15056446)
    5(15153076-15161974)


    ENSEMBL Gene Tree for FIGLA (if available)
    TreeFam Gene Tree for FIGLA (if available) 

    Paralogs
    for FIGLA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FIGLA gene

    FIGLA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FIGLA
    PGOHUM00000234254


    Genomic Variants
    for FIGLA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/310 NCBI SNPs in FIGLA are shown (see all 310)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs574922011,2
    		--70741024(+) CCAACA/GTGGAG 1 -- ds50010--------
    rs794518041,2
    		C,--70741706(+) ATTGTC/ACCACC 1 -- int12Minor allele frequency- A:0.05CSA WA 120
    rs792117461,2
    		F,--70741884(+) GCTCAA/GTTTTC 1 -- int11Minor allele frequency- G:0.11WA 118
    rs116936941,2
    		H--70742032(+) ACTTAG/ACCTTA 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs739401311,2
    		C,--70742301(+) TGACAC/AAAAAT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs739401321,2
    		C,--70742341(+) TGATCG/AAGTCT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1136852741,2
    		--70742608(+) GAATAG/TAAAAA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs170063201,2
    		C,F,H,--70742872(+) CAGAAA/CTCCTT 1 -- int19Minor allele frequency- C:0.07NA NS EA CSA WA 680
    rs67475041,2
    		C,F,H,--70742883(+) GCTCAC/TTCAGC 1 -- int18Minor allele frequency- T:0.05NS EA NA WA 924
    rs119040331,2
    		C,F,H,--70743257(+) TGAACC/TCCAGG 1 -- int18Minor allele frequency- T:0.05NS EA NA WA CSA 530

    HapMap Linkage Disequilibrium report for FIGLA (71004442 - 71017775 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FIGLA: --
    Human Gene Mutation Database (HGMD): FIGLA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FIGLA
    DNA2.0 Custom Variant and Variant Library Synthesis for FIGLA

    Disorders / Diseases
    for FIGLA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FIGLA for disorders           About GeneDecksing

    OMIM gene information: 608697   
    OMIM disorders: 612310  
    UniProtKB/Swiss-Prot: FIGLA_HUMAN, Q6QHK4
  • Defects in FIGLA are the cause of premature ovarian failure type 6 (POF6) [MIM:612310]. An ovarian disorder
    • defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or
    amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol

    3 diseases for FIGLA:    About MalaCards
    premature ovarian failure    premature ovarian failure 6    amenorrhea

    2 diseases from the University of Copenhagen DISEASES database for FIGLA:
    Premature ovarian failure     Infertility

    Export disorders for FIGLA gene to outside databases

    Publications
    for FIGLA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FIGLA gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with FIGLA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes. (PubMed id 12468641)1, 2, 3, 9 Huntriss J.... Picton H.M. (2002)
    2. Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary. (PubMed id 15044608)1, 2, 9 Bayne R.A.L.... Anderson R.A. (2004)
    3. Transcription factor FIGLA is mutated in patients with premature ovarian failure. (PubMed id 18499083)1, 2 Zhao H....Rajkovic A. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Zona pellucida components are present in human fetal ovary before follicle formation. (PubMed id 18502569)1, 9 Tormala R.M....Vaskivuo T.E. (2008)
    6. Premature ovarian failure and gene polymorphisms. (PubMed id 19610175)1 van Dooren M.F....Oldenburg R.A. (2009)
    7. Gene expression analysis of human fetal ovarian primo rdial follicle formation. (PubMed id 19258411)1 Fowler P.A....O'Shaughnessy P.J. (2009)
    8. Candidate genes for premature ovarian failure. (PubMed id 17305537)1 Suzumori N....Rajkovic A. (2007)
    9. Transcriptional regulation of early oogenesis: in sea rch of masters. (PubMed id 16143663)1 Pangas S.A. and Rajkovic A. (2006)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)

    External Searches for FIGLA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FIGLA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 344018 HGNC: 24669 AceView: FIGLA Ensembl:ENSG00000183733 euGenes: HUgn344018
    ECgene: FIGLA H-InvDB: FIGLA

    Other Databases showing FIGLA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FIGLA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FIGLA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FIGLA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FIGLA gene:
    Search GeneIP for patents involving FIGLA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FIGLA gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for FIGLA  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FIGLA   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FIGLA  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FIGLA   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIGLA   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIGLA  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for FIGLA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FIGLA   OriGene Custom Protein Services for FIGLA  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FIGLA
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FIGLA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FIGLA
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FIGLA
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FIGLA
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FIGLA
     GenScript Custom Purified and Recombinant Proteins Services for FIGLA GenScript cDNA clones with any tag delivered in your preferred vector for FIGLA
     GenScript Custom Assay Services for FIGLA GenScript Custom Superior Antibodies Services for FIGLA
     GenScript Custom overexpressing Cell Line Services for FIGLA CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FIGLA promoter
     Search Chromatin IP Primers for FIGLA
     RT2 qPCR Primer Assay in human, mouse, rat FIGLA
     GNC Network for FIGLA
     SABiosciences Custom PCR Arrays for FIGLA
     Search Tocris compounds for FIGLA
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FIGLA antibodies
     FIGLA proteins
     FIGLA lysates
     Search for Antibodies for FIGLA at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FIGLA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for FIGLA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FIGLA
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FIGLA
     SwitchGear Promoter luciferase reporter plasmids for FIGLA
     Search ThermoFisher Antibodies for FIGLA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGLA
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
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