Aliases for FIGF Gene
External Ids for FIGF Gene
Previous HGNC Symbols for FIGF Gene
Previous GeneCards Identifiers for FIGF Gene
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]
GeneCards Summary for FIGF Gene
FIGF (C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D)) is a Protein Coding gene. Diseases associated with FIGF include Breast Cancer and Lymphangioleiomyomatosis. Among its related pathways are p70S6K Signaling and ERK Signaling. GO annotations related to this gene include protein homodimerization activity and chemoattractant activity. An important paralog of this gene is VEGFC.
UniProtKB/Swiss-Prot for FIGF Gene
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.