Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FIGF Gene

protein-coding GIFtS: 68
GCID: GC0XM015363

c-fos induced growth factor (vascular endothelial growth...

(Previous symbol: VEGFD)

Explore 67 diseases affiliated with
FIGF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D)¹ ²
VEGFD¹ ² ³ ⁵
VEGF-D¹ ² ³
Vascular Endothelial Growth Factor D²
C-Fos-Induced Growth Factor³

External Ids:	HGNC: 3708¹	Entrez Gene: 2277²	Ensembl: ENSG00000165197⁷	OMIM: 300091⁵	UniProtKB: O43915³

Export aliases for FIGF gene to outside databases

Previous GC identifers: GC0XM014808 GC0XM014189 GC0XM014565 GC0XM014725 GC0XM015123 GC0XM015273 GC0XM013122

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FIGF:

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor

(PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted

protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate

VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth

factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus.

(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915

Function: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their

proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation

of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated

lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors

Gene Wiki entry for FIGF (C-fos induced growth factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167197.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FIGF gene promoter:
p53 HNF-4alpha1 AREB6 MEF-2A POU2F1 POU2F1a FOXO1a FOXJ2 aMEF-2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FIGF promoter sequence

Search SABiosciences Chromatin IP Primers for FIGF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FIGF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.31 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.31

FIGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FIGF gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM015363: view genomic region (about GC identifiers)

Start:	15,363,713 bp from pter	End:	15,402,577 bp from pter
Size:	38,865 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915 (See protein sequence)

Recommended Name: Vascular endothelial growth factor D precursor

Size: 354 amino acids; 40444 Da

Subunit: Homodimer; non-covalent and antiparallel

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for FIGF:

2XV7 (3D)

Secondary accessions: B2R7Z3

Explore the universe of human proteins at neXtProt for FIGF: NX_O43915

Post-translational modifications:

Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased

activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before

secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent

interactions¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43915

FIGF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004460.1

ENSEMBL proteins:

ENSP00000297904

Reactome Protein details: O43915
Human Recombinant Protein Products for FIGF:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for FIGF (VEGF-D)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: FIGF OriGene Custom Protein Services for FIGF
	GenScript Custom Purified and Recombinant Proteins Services for FIGF
	Novus Biologicals FIGF Proteins Novus Biologicals FIGF Lysates
	Sino Biological Recombinant Protein for FIGF
	ProSpec Recombinant Protein for FIGF
	Uscn Proteins for FIGF

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0016020	membrane	IEA	--
GO:0031093	platelet alpha granule lumen	TAS	--

FIGF for ontologies About GeneDecksing

FIGF Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for FIGF (VEGF-D)
	Browse OriGene Antibodies OriGene Custom Antibody Services for FIGF
	GenScript Custom Superior Antibodies Services for FIGF
	Novus Biologicals FIGF Antibodies
	Abcam antibodies for FIGF
	Uscn Antibodies for FIGF
	ThermoFisher Antibodies for FIGF

Assay Products for FIGF:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for FIGF (VEGF-D) (see all)
	GenScript Custom Assay Services for FIGF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FIGF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FIGF for domains About GeneDecksing

2 InterPro domains/families:

IPR023581 PD_growth_factor_CS

IPR000072 PD_growth_factor

Graphical View of Domain Structure for InterPro Entry O43915

ProtoNet protein and cluster: O43915

2 Blocks protein families:

IPB000072 Platelet-derived growth factor (PDGF)

IPB004153 CXCXC repeat

UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915

Similarity: Belongs to the PDGF/VEGF growth factor family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: VEGFD_HUMAN, O43915

Function: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their

proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation

of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated

lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors

Genatlas biochemistry entry for FIGF:

c-fos induced growth factor

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005161	platelet-derived growth factor receptor binding	TAS	9479493
GO:0005172	vascular endothelial growth factor receptor binding	IPI	9435229
GO:0005515	protein binding	--	--
GO:0008083	growth factor activity	IEA	--
GO:0042056	chemoattractant activity	IDA	19275959

FIGF for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for FIGF:

Decreased focal adhesion (FA)

Increased cell death in breast

9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Figf):

adipose tissue	behavior/neurological	cardiovascular system	growth/size	homeostasis/metabolism
immune system	mortality/aging	normal	tumorigenesis

FIGF for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for FIGF: Figf^tm1Mach Figf^tm1Hrl

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FIGF

miRNA Products:		OriGene 3'-UTR Clone: FIGF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FIGF
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FIGF (see all 14):
		hsa-miR-15a hsa-miR-3120-3p hsa-miR-497 hsa-miR-103a hsa-miR-513b hsa-miR-182 hsa-miR-424 hsa-miR-542-3p

		SwitchGear 3'UTR luciferase reporter plasmid: FIGF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FIGF (see all 7) OriGene shRNA RFP: FIGF OriGene siRNA: FIGF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FIGF
		Sirion Biotech Custom design and validation of potent shRNA sequences against FIGF

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for FIGF
			Sirion Biotech Customized adenovirus for overexpression of FIGF Sirion Biotech Customized adenovirus for potent knockdown of FIGF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIGF (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIGF OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FIGF (NM_004469)
		Sino Biological Human cDNA Clone for FIGF
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIGF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FIGF
		Search LifeMap BioReagents cell lines for FIGF
		Sirion Biotech Customized stable knockdown cell line services for FIGF Sirion Biotech Customized inducible knockdown cell line services for FIGF Sirion Biotech Customized stable overexpressing cell line services for FIGF Sirion Biotech Customized inducible overexpressing cell line services for FIGF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGF

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58	P2Y Receptor Signaling	0.38

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

VEGF Family Ligands and Receptor Interactions

	VEGF Family Ligands and Receptor Interactions	1.00			Development_VEGF-family signaling	0.36
	VEGF Pathway	0.66			Development VEGF-family signaling	0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FIGF

Development VEGF-family signaling

5/62 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FIGF (see all 62)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 GeneGo (Thomson Reuters) Pathway for FIGF

Development VEGF-family signaling

2 BioSystems Pathways for FIGF

	Focal Adhesion
	VEGFR3 signaling in lymphatic endothelium

5/8 Reactome Pathways for FIGF (see all 8)

	VEGF ligand-receptor interactions
	Signaling by VEGF
	Hemostasis
	VEGF binds to VEGFR leading to receptor dimerization
	Platelet degranulation

5/7 Kegg Pathways (Kegg details for FIGF) (see all 7):

	Cytokine-cytokine receptor interaction
	mTOR signaling pathway
	Focal adhesion
	Pathways in cancer
	Renal cell carcinoma

FIGF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FIGF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/54 Interacting proteins for FIGF (O43915³ ENSP00000297904⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FLT4	P35916³, ENSP00000261937⁴	I2D: score=2 STRING: ENSP00000261937
ITGA9	Q13797³, ENSP00000264741⁴	I2D: score=1 STRING: ENSP00000264741
KDR	P35968³, ENSP00000263923⁴	I2D: score=2 STRING: ENSP00000263923
FLT1	ENSP00000282397⁴	STRING: ENSP00000282397
ALB	ENSP00000295897⁴	STRING: ENSP00000295897

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001666	response to hypoxia	--	--
GO:0002576	platelet degranulation	TAS	--
GO:0007596	blood coagulation	TAS	--
GO:0008283	cell proliferation	IEA	--

FIGF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FIGF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FIGF
7 Novoseek chemical compound relationships for FIGF gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vegf	86.5	177	9435229 (5), 16159441 (4), 16682255 (4), 16617567 (4) (see all 98)
tyrosine	50.1	26	12386934 (1), 16334134 (1), 16682255 (1), 10762646 (1) (see all 20)
oxygen	3.85	2	14720324 (1)
nitric oxide	0	6	16418215 (5)
progesterone	0	2	15280403 (1), 14614015 (1)
estrogen	0	2	16080559 (1), 14614015 (1)
tamoxifen	0	2	15280403 (1)

Search CenterWatch for drugs/clinical trials and news about FIGF / VEGFD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FIGF gene:

NM_004469.4

Unigene Cluster for FIGF:

C-fos induced growth factor (vascular endothelial growth factor D)

Hs.11392 [show with all ESTs]

Unigene Representative Sequence: NR_037859

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000297904(uc004cwt.2 uc022bth.1) ENST00000488351

miRNA Products:		OriGene 3'-UTR Clone: FIGF Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FIGF
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FIGF (see all 14):
		hsa-miR-15a hsa-miR-3120-3p hsa-miR-497 hsa-miR-103a hsa-miR-513b hsa-miR-182 hsa-miR-424 hsa-miR-542-3p

		SwitchGear 3'UTR luciferase reporter plasmid: FIGF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FIGF (see all 7) OriGene shRNA RFP: FIGF OriGene siRNA: FIGF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FIGF
		Sirion Biotech Custom design and validation of potent shRNA sequences against FIGF

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIGF (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIGF OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FIGF (NM_004469)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIGF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGF

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FIGF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FIGF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FIGF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FIGF

Additional cDNA sequence:

AJ000185.1 AK223160.1 AK313173.1 BC027948.1 D89630.1 NR_037859.2 Y12863.1

2 DOTS entries:

DT.311515 DT.100810801

24/27 AceView cDNA sequences (see all 27):

AJ000185 Y12863 CA443778 AI572543 BI755551 NM_004469 BF513634 BI772612

CA436993 D89630 AA977475 BC027948 BX091353 AA813617 AW614550 BP381366

H24828 BG506719 BG569935 H24663 AA995128 BI767371 T64149 T64277

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FIGF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATGGCAGG

About this image

FIGF expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Bone

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Beating cell clusters (Spontaneous differen...)

See FIGF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FIGF

SOURCE GeneReport for Unigene cluster: Hs.11392

UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915

Tissue specificity: Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal

muscle, colon, and pancreas

SABiosciences Expression via Pathway-Focused PCR Arrays including FIGF (see all 8):

Growth Factors in human mouse rat

Angiogenic Growth Factors in human mouse rat

VEGF Signaling in human mouse rat

Angiogenesis in human mouse rat

Notch Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FIGF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FIGF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FIGF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FIGF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FIGF gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FIGF¹	c-fos induced growth factor (vascular endothelial growth more	74.01(n) 74.58(a)		395255 NM_204568.1 NP_989899.1
lizard (Anolis carolinensis)	Reptilia	FIGF⁶	--	60(a)	1 ↔ 1	3(121410076-121422277)
zebrafish (Danio rerio)	Actinopterygii	figf¹	c-fos induced growth factor	56.28(n) 49.18(a)		678512 NM_001040178.1 NP_001035268.1

ENSEMBL Gene Tree for FIGF (if available)
TreeFam Gene Tree for FIGF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FIGF gene

VEGFC² PGF² VEGFA² VEGFB²

1 SIMAP similar gene for FIGF using alignment to 1 protein entry: VEGFD_HUMAN:

VEGFC

FIGF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183786935^1,2		--	15363255(+)	`ACTCCA/GTCTAA`	2	--	ds500¹		0	--	--	--	--
rs186247633^1,2		--	15363513(+)	`TGATTC/TGCAGT`	2	--	ds500¹		0	--	--	--	--
rs191490067^1,2		--	15363842(+)	`ACGAAC/TCAAAT`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs148852917^1,2		--	15363844(+)	`GAATCA/GAATTC`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs182045506^1,2		--	15364055(+)	`TGCGCA/GGAGGC`	2	--	nc-transcript-variantut3¹		0	--	--	--	--
rs199572303^1,2		--	15364230(+)	`TGACAG/TGGATG`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs186633943^1,2	C	--	15364232(+)	`ACAGGA/GATGGG`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs151081822^1,2	F	--	15364268(+)	`TCTTTC/TGGCTG`	3	Q R	nc-transcript-variantmis¹		1		NA	4552
rs141051319^1,2	F	--	15364270(+)	`TTTCGG/CCTGTG`	3	/S /R	mis¹		1		NA	4552
rs150253418^1,2	C,F	--	15364358(+)	`TGGTAT/CGAAAG`	3	/H /R	nc-transcript-variantmis¹		1		NA	4548

HapMap Linkage Disequilibrium report for FIGF (15363713 - 15402577 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FIGF
1 CNV: 96490
Locus Specific Mutation Databases (LSDB): FIGF

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FIGF

DNA2.0 Custom Variant and Variant Library Synthesis for FIGF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FIGF for disorders           About GeneDecksing

OMIM gene information: 300091    OMIM disorders: --

20/67 diseases for FIGF (see all 67):    About MalaCards

diffuse large b-cell lymphoma non-small cell lung carcinoma b-cell lymphomas clear cell renal cell carcinoma

lymphedema renal cell carcinoma squamous cell carcinoma papillary renal cell carcinoma

carcinoma oral squamous cell carcinoma inflammatory breast cancer esophageal squamous cell carcinoma

vascular malformations papillary thyroid carcinoma rheumatoid arthritis endometrial carcinoma

lymphangioleiomyomatosis breast cancer kawasaki disease adenocarcinoma

1 disease from the University of Copenhagen DISEASES database for FIGF:

Lymphangioleiomyomatosis

10/46 Novoseek disease relationships for FIGF gene (see all 46) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphatic metastasis	90.4	31	16077915 (3), 19744460 (2), 12576440 (1), 19589137 (1) (see all 21)
metastasis	74.3	183	15803188 (6), 16418215 (5), 12759540 (5), 20448355 (5) (see all 75)
congenital lymphedema	69.4	1	11175851 (1)
lymphedema primary	63.6	5	15693535 (5)
tumors	60.5	147	12148568 (6), 18338756 (5), 12566318 (5), 16311850 (4) (see all 67)
cancer	50	28	18941249 (3), 19462898 (2), 15664381 (1), 16611067 (1) (see all 23)
neovascularization	49.5	4	15032727 (1), 14553837 (1), 15891993 (1), 16407796 (1)
breast carcinoma	49.3	19	17129704 (3), 17069700 (3), 16152591 (3), 18512120 (2) (see all 9)
ductal breast carcinoma	48.2	1	12148568 (1)
primary tumor	46.7	7	15107801 (2), 19744460 (1), 19308692 (1), 20308006 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: FIGF (6 documents)

Export disorders for FIGF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FIGF gene, integrated from 9 sources (see all 318):
(articles sorted by number of sources associating them with FIGF)

Utopia: connect your pdf to the dynamic
world of online information

Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes. (PubMed id 9479493)^{1, 2, 3, 9} Rocchigiani M.... Oliviero S. (1998)
Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. (PubMed id 10542248)^{1, 2, 9} Stacker S.A.... Achen M.G. (1999)
Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). (PubMed id 9435229)^{1, 2, 9} Achen M.G.... Stacker S.A. (1998)
Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. (PubMed id 9205122)^{1, 2, 9} Yamada Y.... Hirata Y. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
VEGF-D expression and lymph vessels play an important role for lymph node metastasis in papillary thyroid carcinoma. (PubMed id 15803188)^{1, 9} Yasuoka H....Kakudo K. (2005)
Expression of hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma. (PubMed id 19096126)^{1, 9} Tzao C....Cheng Y.L. (2008)
Prognostic significance of vascular endothelial growth factor D in breast carcinoma with long-term follow-up. (PubMed id 12576440)^{1, 9} Nakamura Y....Kakudo K. (2003)
Vascular endothelial growth factor-D is a survival factor for human breast carcinoma cells. (PubMed id 16152591)^{1, 9} Akahane M....Thorgeirsson U.P. (2006)
Beta-catenin inversely regulates vascular endothelial growth factor-D mRNA stability. (PubMed id 12920128)^{1, 9} Orlandini M....Oliviero S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2277	HGNC: 3708	AceView: FIGF	Ensembl:ENSG00000165197	euGenes: HUgn2277
ECgene: FIGF	Kegg: 2277	H-InvDB: FIGF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FIGF	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FIGF	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FIGF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FIGF gene:
Search GeneIP for patents involving FIGF

Licensable Technologies for FIGF gene:

Weizmann Institute:

Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for FIGF (VEGF-D)		Browse Cell Culture Products
	ELISAs for FIGF (VEGF-D)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for FIGF (VEGF-D)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for FIGF (VEGF-D)

	Browse OriGene Antibodies		OriGene shRNA RFP for FIGF
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FIGF		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FIGF
	OriGene Protein Over-expression Lysate for FIGF		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for FIGF		OriGene 3'-UTR Clone for FIGF
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIGF		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIGF
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FIGF		OriGene Custom Protein Services for FIGF
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FIGF
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FIGF
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FIGF
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FIGF
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FIGF
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FIGF

	GenScript Custom Purified and Recombinant Proteins Services for FIGF		GenScript cDNA clones with any tag delivered in your preferred vector for FIGF
	GenScript Custom Assay Services for FIGF		GenScript Custom Superior Antibodies Services for FIGF
	GenScript Custom overexpressing Cell Line Services for FIGF		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in FIGF promoter
	Search Chromatin IP Primers for FIGF
	RT² qPCR Primer Assay in human, mouse, rat FIGF
	GNC Network for FIGF
	SABiosciences PCR Arrays including human, mouse, rat FIGF

Search Tocris compounds for FIGF

	Proteins and Antibodies for FIGF
	cDNA Clones for FIGF
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	FIGF antibodies
	FIGF proteins
	FIGF lysates

	Antibodies for FIGF
	See all of Abcam's Antibodies, Kits and Proteins for FIGF
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for FIGF

FIGF Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for FIGF

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGF

	SwitchGear 3'UTR luciferase reporter plasmids for FIGF
	SwitchGear Promoter luciferase reporter plasmids for FIGF

ThermoFisher Antibodies for FIGF

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGF

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FIGF

Sirion Biotech Customized:

	stable knockdown cell line services for FIGF
	inducible knockdown cell line services for FIGF
	design and validation of potent shRNA sequences against FIGF
	adenovirus for potent knockdown of FIGF
	adenovirus for overexpression of FIGF
	stable overexpressing cell line services for FIGF
	inducible overexpressing cell line services for FIGF

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FIGF gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

FIGF Gene

c-fos induced growth factor (vascular endothelial growth...

Aliases
for FIGF gene

Summaries
for FIGF gene

Genomic Views
for FIGF gene

Proteins
for FIGF gene

Protein Domains /
Families
for FIGF gene

Function
for FIGF gene

Pathways & Interactions
for FIGF gene

Drugs & Compounds
for FIGF gene

Transcripts
for FIGF gene

Expression
for FIGF gene

Orthologs
for FIGF gene

Paralogs
for FIGF gene

Genomic Variants
for FIGF gene

Disorders / Diseases
for FIGF gene

Publications
for FIGF gene

External Searches for FIGF gene

Genome Databases showing FIGF gene

Other Databases showing FIGF gene

Specialized Databases showing FIGF gene

Intellectual Property
for FIGF gene

Products
for FIGF gene

View Random Gene

Gastric Cancer
Glioblastoma Multiforme
BREAST CARCINOMA
Melanoma
ESOPHAGEAL CARCINOMA
Hyperplasia
Glioma
dysplasia
LYMPHEDEMA PRIMARY
Carcinoma
ADENOCARCINOMA LUNG
COLON CARCINOMA
Myocardial Ischemia
Atherosclerosis
Lymphatic Metastasis
Breast Cancer
ductal breast carcinoma
Neovascularization
primary tumor
inflammatory breast cancer
NSCLC
Adenocarcinoma
THYROID PAPILLARY CARCINOMA
Cancer
Carcinoma Renal Cell
Colorectal Carcinoma
Cancer Lung
ADENOCARCINOMA GASTRIC
Congenital lymphedema
Pathological Processes
GASTRIC CARCINOMA
Adenoma
Colorectal Cancer
OVARIAN CARCINOMA
HNSCC
Inflammation
solid tumor
Carcinoma Squamous Cell
ENDOMETRIAL CARCINOMA
Rheumatoid Arthritis
prostate cancer
Tumors
Metastasis
Carcinoma Ductal
Necrosis
Glioblastoma

Advanced Search

Export list of displayed genes

FIGF Gene

c-fos induced growth factor (vascular endothelial growth...

Aliasesfor FIGF gene

Summariesfor FIGF gene

Genomic Viewsfor FIGF gene

Proteinsfor FIGF gene

Protein Domains /Familiesfor FIGF gene

Functionfor FIGF gene

Pathways & Interactionsfor FIGF gene

Drugs & Compoundsfor FIGF gene

Transcriptsfor FIGF gene

Expression for FIGF gene

Orthologsfor FIGF gene

Paralogsfor FIGF gene

Genomic Variantsfor FIGF gene

Disorders / Diseasesfor FIGF gene

Publicationsfor FIGF gene

External Searches for FIGF gene

Genome Databases showing FIGF gene

Other Databases showing FIGF gene

Specialized Databases showing FIGF gene

Intellectual Propertyfor FIGF gene

Productsfor FIGF gene

View Random Gene

Aliases
for FIGF gene

Summaries
for FIGF gene

Genomic Views
for FIGF gene

Proteins
for FIGF gene

Protein Domains /
Families
for FIGF gene

Function
for FIGF gene

Pathways & Interactions
for FIGF gene

Drugs & Compounds
for FIGF gene

Transcripts
for FIGF gene

Expression
for FIGF gene

Orthologs
for FIGF gene

Paralogs
for FIGF gene

Genomic Variants
for FIGF gene

Disorders / Diseases
for FIGF gene

Publications
for FIGF gene

Intellectual Property
for FIGF gene

Products
for FIGF gene