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FIGF Gene

protein-coding   GIFtS: 67
GCID: GC0XM015363

C-Fos Induced Growth Factor (Vascular Endothelial Growth...


(Previous symbol: VEGFD)
  See FIGF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D)1 2
VEGFD1 2 3 5
VEGF-D2 3
Vascular Endothelial Growth Factor D2
C-Fos-Induced Growth Factor3

External Ids:    HGNC: 37081   Entrez Gene: 22772   Ensembl: ENSG000001651977   OMIM: 3000915   UniProtKB: O439153   

Export aliases for FIGF gene to outside databases

Previous GC identifers: GC0XM014808 GC0XM014189 GC0XM014565 GC0XM014725 GC0XM015123 GC0XM015273 GC0XM013122


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FIGF Gene:
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth
factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This
secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and
activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular
endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR
(GeneID 8544) locus. (provided by RefSeq, Feb 2011)

GeneCards Summary for FIGF Gene:
FIGF (c-fos induced growth factor (vascular endothelial growth factor D)) is a protein-coding gene. Diseases associated with FIGF include kidney angiomyolipoma, and glioblastoma multiforme. GO annotations related to this gene include protein homodimerization activity and chemoattractant activity. An important paralog of this gene is VEGFC.

UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915
Function: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their
proliferation and migration and also has effects on the permeability of blood vessels. May function in the
formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of
differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4)
receptors

Gene Wiki entry for FIGF (C-fos induced growth factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FIGF gene promoter:
         p53   HNF-4alpha1   AREB6   MEF-2A   POU2F1   POU2F1a   FOXO1a   FOXJ2   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FIGF promoter sequence
   Search Chromatin IP Primers for FIGF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FIGF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.31   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.31

FIGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FIGF gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM015363:  view genomic region     (about GC identifiers)

Start:
15,363,713 bp from pter      End:
15,402,535 bp from pter
Size:
38,823 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915 (See protein sequence)
Recommended Name: Vascular endothelial growth factor D precursor  
Size: 354 amino acids; 40444 Da
Subunit: Homodimer; non-covalent and antiparallel
1 PDB 3D structure from and Proteopedia for FIGF:
2XV7 (3D)    
Secondary accessions: B2R7Z3

Explore the universe of human proteins at neXtProt for FIGF: NX_O43915

Explore proteomics data for FIGF at MOPED

Post-translational modifications: 

  • Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased
    activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before
    secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by
    non-covalent interactions1
  • Glycosylation2 at Asn155, Asn185, Asn287
  • Modification sites at PhosphoSitePlus

  • See FIGF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004460.1  
    ENSEMBL proteins: 
     ENSP00000297904  
    Reactome Protein details: O43915

    FIGF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FIGF (VEGF-D)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FIGF
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FIGF
    GenScript Custom Purified and Recombinant Proteins Services for FIGF
    Novus Biologicals FIGF Proteins
    Novus Biologicals FIGF Lysates
    Sino Biological Recombinant Protein for FIGF
    Sino Biological Cell Lysate for FIGF
    ProSpec Recombinant Protein for FIGF
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FIGF 

     
    antibodies-online proteins for FIGF (23 products) 

     
    antibodies-online peptides for FIGF

    FIGF Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FIGF (VEGF-D)
    OriGene Antibodies for FIGF
    OriGene Custom Antibody Services for FIGF
    Novus Biologicals FIGF Antibodies
    Abcam antibodies for FIGF
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for FIGF
    antibodies-online antibodies for FIGF (110 products) 

    FIGF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FIGF
    R&D Systems ELISAs for FIGF (VEGF-D)         (see all)
    GenScript Custom Assay Services for FIGF
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FIGF 
    antibodies-online kits for FIGF (30 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023581 PD_growth_factor_CS
     IPR000072 PDGF/VEGF_dom

    Graphical View of Domain Structure for InterPro Entry O43915

    ProtoNet protein and cluster: O43915

    2 Blocks protein domains:
    IPB000072 Platelet-derived growth factor (PDGF)
    IPB004153 CXCXC repeat


    UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915
    Similarity: Belongs to the PDGF/VEGF growth factor family


    Find genes that share domains with FIGF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VEGFD_HUMAN, O43915
    Function: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their
    proliferation and migration and also has effects on the permeability of blood vessels. May function in the
    formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of
    differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4)
    receptors

         Genatlas biochemistry entry for FIGF:
    c-fos induced growth factor

         Summary: 
    FIGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Neurons: Dopaminergic neuron-like cells , Dopaminergic neuron-like cells
    Brain: Dopaminergic neuron-like cells , Dopaminergic neuron-like cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005161platelet-derived growth factor receptor binding TAS9479493
    GO:0005172vascular endothelial growth factor receptor binding IPI9435229
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
    GO:0042056chemoattractant activity IDA19275959
         
    Find genes that share ontologies with FIGF           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FIGF:
     Decreased focal adhesion (FA)   Increased cell death in breast 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Figf):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism 
     immune system  mortality/aging  normal  tumorigenesis 

    Find genes that share phenotypes with FIGF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FIGF: Figftm1Mach Figftm1Hrl

       genOway: Develop your customized and physiologically relevant rodent model for FIGF

    miRNA
    Products:
        
    miRTarBase miRNAs that target FIGF:
    hsa-mir-26b-5p (MIRT030196), hsa-mir-335-5p (MIRT018981)

    Block miRNA regulation of human, mouse, rat FIGF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FIGF (see all 14):
    hsa-miR-15a hsa-miR-3120-3p hsa-miR-497 hsa-miR-103a hsa-miR-513b hsa-miR-182 hsa-miR-424 hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidFIGF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FIGF
    Predesigned siRNA for gene silencing in human, mouse, rat FIGF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FIGF

    Clone
    Products:
         
    OriGene clones in human, mouse for FIGF (see all 6)
    OriGene ORF clones in mouse, rat for FIGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FIGF (NM_004469)
    Sino Biological Human cDNA Clone for FIGF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FIGF
    Browse ESI BIO Cell Lines and PureStem Progenitors for FIGF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VEGFD_HUMAN, O43915: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0016020membrane IEA--
    GO:0031093platelet alpha granule lumen TAS--

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FIGF About   (see all 27)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1VEGF Pathway
    VEGF Family Ligands and Receptor Interactions0.66
    Development VEGF family signaling0.36
    VEGF Pathway0.66
    2Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40


    Find genes that share SuperPaths with FIGF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FIGF (see all 62)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FIGF
        Development VEGF-family signaling

    2 BioSystems Pathways for FIGF
        Focal Adhesion
    VEGFR3 signaling in lymphatic endothelium

    1 Sino Biological Pathway for FIGF
        VEGF Signaling

    3 Reactome Pathways for FIGF
        VEGF ligand-receptor interactions
    VEGF binds to VEGFR leading to receptor dimerization
    Platelet degranulation


    Selected Kegg Pathways  (Kegg details for FIGF) (see all 6):
        Ras signaling pathway
    Rap1 signaling pathway
    Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FIGF (see all 8): 
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              VEGF Signaling in human mouse rat
              Angiogenesis in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FIGF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FIGF (O439153 ENSP000002979044) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLT4P359163, ENSP000002619374I2D: score=2 STRING: ENSP00000261937
    ITGA9Q137973, ENSP000002647414I2D: score=1 STRING: ENSP00000264741
    KDRP359683, ENSP000002639234I2D: score=2 STRING: ENSP00000263923
    FLT1ENSP000002823974STRING: ENSP00000282397
    ALBENSP000002958974STRING: ENSP00000295897
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0002576platelet degranulation TAS--
    GO:0007596blood coagulation TAS--
    GO:0008283cell proliferation IEA--
    GO:0008284positive regulation of cell proliferation IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FIGF (VEGFD)

    7 Novoseek inferred chemical compound relationships for FIGF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 86.5 177 9435229 (5), 16159441 (4), 16682255 (4), 16617567 (4) (see all 98)
    tyrosine 50.1 26 12386934 (1), 16334134 (1), 16682255 (1), 10762646 (1) (see all 20)
    oxygen 3.85 2 14720324 (1)
    nitric oxide 0 6 16418215 (5)
    progesterone 0 2 15280403 (1), 14614015 (1)
    estrogen 0 2 16080559 (1), 14614015 (1)
    tamoxifen 0 2 15280403 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FIGF gene: 
    NM_004469.4  

    Unigene Cluster for FIGF:

    C-fos induced growth factor (vascular endothelial growth factor D)
    Hs.11392  [show with all ESTs]
    Unigene Representative Sequence: BC027948
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297904(uc004cwt.2 uc022bth.1) ENST00000488351
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FIGF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FIGF (see all 14):
    hsa-miR-15a hsa-miR-3120-3p hsa-miR-497 hsa-miR-103a hsa-miR-513b hsa-miR-182 hsa-miR-424 hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidFIGF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FIGF
    Predesigned siRNA for gene silencing in human, mouse, rat FIGF
    Clone
    Products:
         
    OriGene clones in human, mouse for FIGF (see all 6)
    OriGene ORF clones in mouse, rat for FIGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FIGF (NM_004469)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGF
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FIGF
    OriGene qSTAR qPCR primer pairs in human, mouse for FIGF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FIGF
      QuantiTect SYBR Green Assays in human, mouse, rat FIGF
      QuantiFast Probe-based Assays in human, mouse, rat FIGF

    Additional mRNA sequence: 

    AJ000185.1 AK223160.1 AK313173.1 BC027948.1 D89630.1 Y12863.1 

    2 DOTS entries:

    DT.311515  DT.100810801 

    Selected AceView cDNA sequences (see all 27):

    NM_004469 AI572543 BI755551 Y12863 CA443778 AJ000185 AA813617 D89630 
    BI772612 BX091353 BF513634 AA977475 AW614550 CA436993 BC027948 BP381366 
    H24663 BG506719 H24828 BG569935 AA995128 BI767371 T64149 T64277 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FIGF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATGGCAGG
    FIGF Expression
    About this image


    FIGF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium
    FIGF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FIGF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.11392

    UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915
    Tissue specificity: Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in
    skeletal muscle, colon, and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FIGF (see all 8): 
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              VEGF Signaling in human mouse rat
              Angiogenesis in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FIGF
    OriGene qSTAR qPCR primer pairs in human, mouse for FIGF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FIGF
    QuantiTect SYBR Green Assays in human, mouse, rat FIGF
    QuantiFast Probe-based Assays in human, mouse, rat FIGF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for FIGF gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Figf1 , 5 c-fos induced growth factor1, 5 86.21(n)1
    85.27(a)1
      X (76.35 cM)5
    142051  NM_010216.11  NP_034346.11 
     1643733785 
    chicken
    (Gallus gallus)
    Aves FIGF1 c-fos induced growth factor (vascular endothelial growth more 73.06(n)
    73.06(a)
      395255  NM_204568.1  NP_989899.1 
    lizard
    (Anolis carolinensis)
    Reptilia FIGF6
    c-fos induced growth factor (vascular endothelial ...
    60(a)
    1 ↔ 1
    3(121408953-121422277)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia figf1 c-fos induced growth factor (vascular endothelial growth more 63.41(n)
    59.76(a)
      100144690  XM_002942563.2  XP_002942609.2 
    zebrafish
    (Danio rerio)
    Actinopterygii figf1 c-fos induced growth factor 56.28(n)
    49.18(a)
      678512  NM_001040178.1  NP_001035268.1 


    ENSEMBL Gene Tree for FIGF (if available)
    TreeFam Gene Tree for FIGF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FIGF gene
    VEGFC2  
    1 SIMAP similar gene for FIGF using alignment to 1 protein entry:     VEGFD_HUMAN:
    VEGFC

    Find genes that share paralogs with FIGF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FIGF (see all 543)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837869351,2
    --15278210(+) ACTCCA/GTCTAA 1 -- ds50010--------
    rs1862476331,2
    --15278468(+) TGATTC/TGCAGT 1 -- ds50010--------
    rs1914900671,2
    --15278797(+) ACGAAC/TCAAAT 1 -- ut310--------
    rs1488529171,2
    --15278799(+) GAATCA/GAATTC 1 -- ut310--------
    rs1820455061,2
    C--15279010(+) TGCGCA/GGAGGC 1 -- ut310--------
    rs3776959361,2
    C--15279114(+) AATGG-/TTTTTT 1 -- ut310--------
    rs1995723031,2
    C--15279185(+) TGACAG/TGGATG 1 -- ut310--------
    rs1866339431,2
    C--15279187(+) ACAGGA/GATGGG 1 -- ut310--------
    rs1510818221,2
    F--15279223(+) TCTTTC/TGGCTG 2 Q R mis11Minor allele frequency- T:0.00NA 4552
    rs1410513191,2
    F--15279225(+) TTTCGG/CCTGTG 2 /S /R mis11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for FIGF (15363713 - 15402535 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FIGF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6813CNV Loss18451855
    nsv528343CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): FIGF

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FIGF
    DNA2.0 Custom Variant and Variant Library Synthesis for FIGF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300091    OMIM disorders: --

    4 diseases for FIGF:    
    About MalaCards
    kidney angiomyolipoma    glioblastoma multiforme    papillary thyroid carcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for FIGF:
    Lymphangioleiomyomatosis

    Find genes that share disorders with FIGF           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FIGF gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphatic metastasis 90.4 31 16077915 (3), 19744460 (2), 12576440 (1), 19589137 (1) (see all 21)
    metastasis 74.3 183 15803188 (6), 16418215 (5), 12759540 (5), 20448355 (5) (see all 75)
    congenital lymphedema 69.4 1 11175851 (1)
    lymphedema primary 63.6 5 15693535 (5)
    tumors 60.5 147 12148568 (6), 18338756 (5), 12566318 (5), 16311850 (4) (see all 67)
    cancer 50 28 18941249 (3), 19462898 (2), 15664381 (1), 16611067 (1) (see all 23)
    neovascularization 49.5 4 15032727 (1), 14553837 (1), 15891993 (1), 16407796 (1)
    breast carcinoma 49.3 19 17129704 (3), 17069700 (3), 16152591 (3), 18512120 (2) (see all 9)
    ductal breast carcinoma 48.2 1 12148568 (1)
    primary tumor 46.7 7 15107801 (2), 19744460 (1), 19308692 (1), 20308006 (1) (see all 5)

    Genetic Association Database (GAD): FIGF
    Human Genome Epidemiology (HuGE) Navigator: FIGF (6 documents)

    Export disorders for FIGF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FIGF gene, integrated from 10 sources (see all 327):
    (articles sorted by number of sources associating them with FIGF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes. (PubMed id 9479493)1, 2, 3, 9 Rocchigiani M.... Oliviero S. (Genomics 1998)
    2. Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. (PubMed id 10542248)1, 2, 9 Stacker S.A.... Achen M.G. (J. Biol. Chem. 1999)
    3. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). (PubMed id 9435229)1, 2, 9 Achen M.G.... Stacker S.A. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    4. Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. (PubMed id 9205122)1, 2, 9 Yamada Y.... Hirata Y. (Genomics 1997)
    5. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    6. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    7. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    8. Candidate gene analysis in primary lymphedema. (PubMed id 18564921)1, 4 Ferrell R.E....Finegold D.N. (Lymphat Res Biol 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. VEGF-D expression and lymph vessels play an important role for lymph node metastasis in papillary thyroid carcinoma. (PubMed id 15803188)1, 9 Yasuoka H....Kakudo K. (Mod. Pathol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2277 HGNC: 3708 AceView: FIGF Ensembl:ENSG00000165197 euGenes: HUgn2277
    ECgene: FIGF Kegg: 2277 H-InvDB: FIGF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FIGF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FIGF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FIGF gene:
    Search GeneIP for patents involving FIGF

    Licensable Technologies for FIGF gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     PCR Arrays including human, mouse, rat FIGF Search Chromatin IP Primers for FIGF
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FIGF  GeneGlobe Interaction Network for FIGF
     Regulatory tfbs in FIGF promoter
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     ThermoFisher Antibodies for FIGF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGF
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     antibodies-online proteins for FIGF (23 products)
           
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