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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FIGF Gene

protein-coding   GIFtS: 66
GCID: GC0XM015363

C-Fos Induced Growth Factor (Vascular Endothelial Growth...


(Previous symbol: VEGFD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D)1 2
VEGFD1 2 3 5
VEGF-D2 3
Vascular Endothelial Growth Factor D2
C-Fos-Induced Growth Factor3

External Ids:    HGNC: 37081   Entrez Gene: 22772   Ensembl: ENSG000001651977   OMIM: 3000915   UniProtKB: O439153   

Export aliases for FIGF gene to outside databases

Previous GC identifers: GC0XM014808 GC0XM014189 GC0XM014565 GC0XM014725 GC0XM015123 GC0XM015273 GC0XM013122


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FIGF Gene:
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth
factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This
secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and
activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular
endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR
(GeneID 8544) locus. (provided by RefSeq, Feb 2011)

GeneCards Summary for FIGF Gene: 
FIGF (c-fos induced growth factor (vascular endothelial growth factor D)) is a protein-coding gene. Diseases associated with FIGF include lymphangioleiomyomatosis, and lymphedema, and among its related super-pathways are VEGF Family Ligands and Receptor Interactions and Focal Adhesion. GO annotations related to this gene include protein homodimerization activity and chemoattractant activity. An important paralog of this gene is VEGFC.

UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915
Function: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their
proliferation and migration and also has effects on the permeability of blood vessels. May function in the
formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of
differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4)
receptors

Gene Wiki entry for FIGF (C-fos induced growth factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FIGF gene promoter:
         p53   HNF-4alpha1   AREB6   MEF-2A   POU2F1   POU2F1a   FOXO1a   FOXJ2   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FIGF promoter sequence
   Search SABiosciences Chromatin IP Primers for FIGF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FIGF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.31   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.31

FIGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FIGF gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM015363:  view genomic region     (about GC identifiers)

Start:
15,363,713 bp from pter      End:
15,402,535 bp from pter
Size:
38,823 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915 (See protein sequence)
Recommended Name: Vascular endothelial growth factor D precursor  
Size: 354 amino acids; 40444 Da
Subunit: Homodimer; non-covalent and antiparallel
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for FIGF:
2XV7 (3D)    
Secondary accessions: B2R7Z3

Explore the universe of human proteins at neXtProt for FIGF: NX_O43915

Explore proteomics data for FIGF at MOPED 

Post-translational modifications:

  • UniProtKB: Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased
    activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before
    secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by
    non-covalent interactions
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43915

  • FIGF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FIGF Protein Expression
    REFSEQ proteins: NP_004460.1  
    ENSEMBL proteins: 
     ENSP00000297904  
    Reactome Protein details: O43915
    Human Recombinant Protein Products for FIGF: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FIGF (VEGF-D)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FIGF
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FIGF
    GenScript Custom Purified and Recombinant Proteins Services for FIGF
    Novus Biologicals FIGF Proteins
    Novus Biologicals FIGF Lysates
    Sino Biological Recombinant Protein for FIGF
    Sino Biological Cell Lysate for FIGF 
    ProSpec Recombinant Protein for FIGF
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0016020membrane IEA--
    GO:0031093platelet alpha granule lumen TAS--

    FIGF for ontologies           About GeneDecksing



    FIGF Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FIGF (VEGF-D)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FIGF
    GenScript Custom Superior Antibodies Services for FIGF
    Novus Biologicals FIGF Antibodies
    Abcam antibodies for FIGF
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for FIGF
    LSBio Antibodies in human, mouse, rat for FIGF 

    Assay Products for FIGF: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FIGF
    R&D Systems ELISAs for FIGF (VEGF-D)         (see all)
    GenScript Custom Assay Services for FIGF
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR023581 PD_growth_factor_CS
     IPR000072 PD_growth_factor

    Graphical View of Domain Structure for InterPro Entry O43915

    ProtoNet protein and cluster: O43915

    2 Blocks protein domains:
    IPB000072 Platelet-derived growth factor (PDGF)
    IPB004153 CXCXC repeat


    UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915
    Similarity: Belongs to the PDGF/VEGF growth factor family


    FIGF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VEGFD_HUMAN, O43915
    Function: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their
    proliferation and migration and also has effects on the permeability of blood vessels. May function in the
    formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of
    differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4)
    receptors

         Genatlas biochemistry entry for FIGF:
    c-fos induced growth factor

         Summary:
    FIGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Dopaminergic neuron-like cells from Brain

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005161platelet-derived growth factor receptor binding TAS9479493
    GO:0005172vascular endothelial growth factor receptor binding IPI9435229
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
    GO:0042056chemoattractant activity IDA19275959
         
    FIGF for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FIGF:
     Decreased focal adhesion (FA)   Increased cell death in breast 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Figf):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism 
     immune system  mortality/aging  normal  tumorigenesis 

    FIGF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FIGF: Figftm1Mach Figftm1Hrl

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FIGF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FIGF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FIGF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FIGF 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FIGF
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FIGF (see all 14):
    hsa-miR-15a hsa-miR-3120-3p hsa-miR-497 hsa-miR-103a hsa-miR-513b hsa-miR-182 hsa-miR-424 hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidFIGF 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FIGF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FIGF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FIGF
    Sirion Biotech Customized adenovirus for overexpression of FIGF

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FIGF (see all 7)
    OriGene ORF clones in mouse, rat for FIGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FIGF (NM_004469)
    Sino Biological Human cDNA Clone for FIGF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGF
    Sirion Biotech Customized lentivirus for stable overexpression of FIGF 
                         Customized lentivirus expression plasmids for stable overexpression of FIGF 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FIGF
    Search LifeMap BioReagents cell lines for FIGF
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FIGF About   (see all 26)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1VEGF Family Ligands and Receptor Interactions
    VEGF Family Ligands and Receptor Interactions0.66
    Development VEGF-family signaling0.36
    VEGF Pathway0.66
    2Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FIGF
        Development VEGF-family signaling

    5/62 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FIGF (see all 62)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FIGF
        Development VEGF-family signaling

    2 BioSystems Pathways for FIGF
        Focal Adhesion
    VEGFR3 signaling in lymphatic endothelium

    1 Sino Biological Pathway for FIGF 
        VEGF Signaling

    5/8        Reactome Pathways for FIGF (see all 8)
        VEGF ligand-receptor interactions
    Signaling by VEGF
    Hemostasis
    VEGF binds to VEGFR leading to receptor dimerization
    Platelet degranulation


    4         Kegg Pathways  (Kegg details for FIGF):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Focal adhesion
    Pathways in cancer


    FIGF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FIGF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for FIGF (O439153 ENSP000002979044) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLT4P359163, ENSP000002619374I2D: score=2 STRING: ENSP00000261937
    ITGA9Q137973, ENSP000002647414I2D: score=1 STRING: ENSP00000264741
    KDRP359683, ENSP000002639234I2D: score=2 STRING: ENSP00000263923
    FLT1ENSP000002823974STRING: ENSP00000282397
    ALBENSP000002958974STRING: ENSP00000295897
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0002576platelet degranulation TAS--
    GO:0007596blood coagulation TAS--
    GO:0008283cell proliferation IEA--
    GO:0008284positive regulation of cell proliferation IEA--

    FIGF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FIGF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FIGF (VEGFD)

    7 Novoseek inferred chemical compound relationships for FIGF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 86.5 177 9435229 (5), 16159441 (4), 16682255 (4), 16617567 (4) (see all 98)
    tyrosine 50.1 26 12386934 (1), 16334134 (1), 16682255 (1), 10762646 (1) (see all 20)
    oxygen 3.85 2 14720324 (1)
    nitric oxide 0 6 16418215 (5)
    progesterone 0 2 15280403 (1), 14614015 (1)
    estrogen 0 2 16080559 (1), 14614015 (1)
    tamoxifen 0 2 15280403 (1)

    Search CenterWatch for drugs/clinical trials and news about FIGF / VEGFD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FIGF gene: 
    NM_004469.4  

    Unigene Cluster for FIGF:

    C-fos induced growth factor (vascular endothelial growth factor D)
    Hs.11392  [show with all ESTs]
    Unigene Representative Sequence: BC027948
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297904(uc004cwt.2 uc022bth.1) ENST00000488351
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FIGF
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FIGF (see all 14):
    hsa-miR-15a hsa-miR-3120-3p hsa-miR-497 hsa-miR-103a hsa-miR-513b hsa-miR-182 hsa-miR-424 hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidFIGF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FIGF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FIGF
    Clone
    Products:
         
    OriGene clones in human, mouse for FIGF (see all 7)
    OriGene ORF clones in mouse, rat for FIGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FIGF (NM_004469)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FIGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGF
    Sirion Biotech Customized lentivirus for stable overexpression of FIGF 
                         Customized lentivirus expression plasmids for stable overexpression of FIGF 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FIGF
    OriGene qSTAR qPCR primer pairs in human, mouse for FIGF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FIGF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FIGF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FIGF

    Additional mRNA sequence: 

    AJ000185.1 AK223160.1 AK313173.1 BC027948.1 D89630.1 Y12863.1 

    2 DOTS entries:

    DT.311515  DT.100810801 

    24/27 AceView cDNA sequences (see all 27):

    Y12863 AJ000185 AI572543 NM_004469 CA443778 BI755551 BF513634 BI772612 
    BX091353 AA813617 CA436993 AW614550 AA977475 BP381366 BC027948 D89630 
    BG506719 H24663 H24828 BG569935 AA995128 BI767371 T64149 T64277 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FIGF expression in normal human tissues (normalized intensities)      FIGF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATGGCAGG
    FIGF Expression
    About this image


    FIGF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Testicular Interstitial Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex

    See FIGF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FIGF

    SOURCE GeneReport for Unigene cluster: Hs.11392

    UniProtKB/Swiss-Prot: VEGFD_HUMAN, O43915
    Tissue specificity: Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in
    skeletal muscle, colon, and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including FIGF (see all 8): 
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              VEGF Signaling in human mouse rat
              Angiogenesis in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FIGF
    OriGene qSTAR qPCR primer pairs in human, mouse for FIGF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FIGF
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FIGF
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FIGF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FIGF gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Figf1 , 5 c-fos induced growth factor1, 5 86.21(n)1
    85.27(a)1
      X (76.35 cM)5
    142051  NM_010216.11  NP_034346.11 
     1643733785 
    chicken
    (Gallus gallus)
    Aves FIGF1 c-fos induced growth factor (vascular endothelial growth more 74.01(n)
    74.58(a)
      395255  NM_204568.1  NP_989899.1 
    lizard
    (Anolis carolinensis)
    Reptilia FIGF6
    Uncharacterized protein
    60(a)
    1 ↔ 1
    3(121408953-121422277)
    zebrafish
    (Danio rerio)
    Actinopterygii figf1 c-fos induced growth factor 56.28(n)
    49.18(a)
      678512  NM_001040178.1  NP_001035268.1 


    ENSEMBL Gene Tree for FIGF (if available)
    TreeFam Gene Tree for FIGF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FIGF gene
    VEGFC2  
    1 SIMAP similar gene for FIGF using alignment to 1 protein entry:     VEGFD_HUMAN:
    VEGFC

    FIGF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/543 SNPs in FIGF are shown (see all 543)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837869351,2
    --15278210(+) ACTCCA/GTCTAA 1 -- ds50010--------
    rs1862476331,2
    --15278468(+) TGATTC/TGCAGT 1 -- ds50010--------
    rs1914900671,2
    --15278797(+) ACGAAC/TCAAAT 1 -- ut310--------
    rs1488529171,2
    --15278799(+) GAATCA/GAATTC 1 -- ut310--------
    rs1820455061,2
    C--15279010(+) TGCGCA/GGAGGC 1 -- ut310--------
    rs3776959361,2
    C--15279114(+) AATGG-/TTTTTT 1 -- ut310--------
    rs1995723031,2
    C--15279185(+) TGACAG/TGGATG 1 -- ut310--------
    rs1866339431,2
    C--15279187(+) ACAGGA/GATGGG 1 -- ut310--------
    rs1510818221,2
    F--15279223(+) TCTTTC/TGGCTG 2 Q R mis11Minor allele frequency- T:0.00NA 4552
    rs1410513191,2
    F--15279225(+) TTTCGG/CCTGTG 2 /S /R mis11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for FIGF (15363713 - 15402535 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FIGF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6813CNV Loss18451855
    nsv528343CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): FIGF
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FIGF
    DNA2.0 Custom Variant and Variant Library Synthesis for FIGF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300091    OMIM disorders: --

    20/57 diseases for FIGF (see all 57):    About MalaCards
    lymphangioleiomyomatosis    lymphedema    vascular malformations    kidney cancer
    papillary renal cell carcinoma    gallbladder cancer    gastric adenocarcinoma    papillary thyroid carcinoma
    endotheliitis    glioblastoma    clear cell renal cell carcinoma    angiosarcoma
    gastroenteritis    lung adenocarcinoma    renal cell carcinoma    endometrial adenocarcinoma
    kawasaki disease    esophagitis    endometrial carcinoma    oral squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for FIGF:
    Lymphangioleiomyomatosis

    FIGF for disorders           About GeneDecksing

    10/46 Novoseek inferred disease relationships for FIGF gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphatic metastasis 90.4 31 16077915 (3), 19744460 (2), 12576440 (1), 19589137 (1) (see all 21)
    metastasis 74.3 183 15803188 (6), 16418215 (5), 12759540 (5), 20448355 (5) (see all 75)
    congenital lymphedema 69.4 1 11175851 (1)
    lymphedema primary 63.6 5 15693535 (5)
    tumors 60.5 147 12148568 (6), 18338756 (5), 12566318 (5), 16311850 (4) (see all 67)
    cancer 50 28 18941249 (3), 19462898 (2), 15664381 (1), 16611067 (1) (see all 23)
    neovascularization 49.5 4 15032727 (1), 14553837 (1), 15891993 (1), 16407796 (1)
    breast carcinoma 49.3 19 17129704 (3), 17069700 (3), 16152591 (3), 18512120 (2) (see all 9)
    ductal breast carcinoma 48.2 1 12148568 (1)
    primary tumor 46.7 7 15107801 (2), 19744460 (1), 19308692 (1), 20308006 (1) (see all 5)

    Genetic Association Database (GAD): FIGF
    Human Genome Epidemiology (HuGE) Navigator: FIGF (6 documents)

    Export disorders for FIGF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FIGF gene, integrated from 9 sources (see all 326):
    (articles sorted by number of sources associating them with FIGF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes. (PubMed id 9479493)1, 2, 3, 9 Rocchigiani M.... Oliviero S. (1998)
    2. Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. (PubMed id 10542248)1, 2, 9 Stacker S.A.... Achen M.G. (1999)
    3. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). (PubMed id 9435229)1, 2, 9 Achen M.G.... Stacker S.A. (1998)
    4. Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. (PubMed id 9205122)1, 2, 9 Yamada Y.... Hirata Y. (1997)
    5. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    6. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
    7. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
    8. Candidate gene analysis in primary lymphedema. (PubMed id 18564921)1, 4 Ferrell R.E....Finegold D.N. (2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. VEGF-D expression and lymph vessels play an important role for lymph node metastasis in papillary thyroid carcinoma. (PubMed id 15803188)1, 9 Yasuoka H....Kakudo K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2277 HGNC: 3708 AceView: FIGF Ensembl:ENSG00000165197 euGenes: HUgn2277
    ECgene: FIGF Kegg: 2277 H-InvDB: FIGF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FIGF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FIGF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FIGF gene:
    Search GeneIP for patents involving FIGF

    Licensable Technologies for FIGF gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FIGF
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FIGF
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     Regulatory tfbs in FIGF promoter
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     SABiosciences PCR Arrays including human, mouse, rat FIGF
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     Gene Synthesis
     Protein Engineering
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIGF
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     SwitchGear Promoter luciferase reporter plasmids for FIGF
     ThermoFisher Antibodies for FIGF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIGF
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FIGF
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FIGF
    Customized:
     lentivirus for stable overexpression of FIGF
     lentivirus expression plasmids for stable overexpression of FIGF
     adenovirus for overexpression of FIGF
     LSBio Antibodies in human, mouse, rat for FIGF
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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