Aliases for FIG4 Gene
Aliases for FIG4 Gene
- FIG4 Phosphoinositide 5-Phosphatase 2 3 5
- KIAA0274 2 3 4
- Phosphatidylinositol 3,5-Bisphosphate 5-Phosphatase 3 4
- SAC Domain-Containing Protein 3 3 4
- SAC3 3 4
- FIG4 Homolog, SAC1 Lipid Phosphatase Domain Containing (S. Cerevisiae) 2
- FIG4 Homolog, SAC1 Domain Containing Lipid Phosphatase 3
- FIG4 Homolog, SAC1 Lipid Phosphatase Domain Containing 3
- FIG4 Homolog, SAC Domain Containing Lipid Phosphatase 3
- Sac Domain-Containing Inositol Phosphatase 3 3
External Ids for FIG4 Gene
- HGNC: 16873
- Entrez Gene: 9896
- Ensembl: ENSG00000112367
- OMIM: 609390
- UniProtKB: Q92562
Previous HGNC Symbols for FIG4 Gene
- KIAA0274
Previous GeneCards Identifiers for FIG4 Gene
- GC06P110120
- GC06P110012
- GC06P107578
Summaries for FIG4 Gene
-
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]
GeneCards Summary for FIG4 Gene
FIG4 (FIG4 Phosphoinositide 5-Phosphatase) is a Protein Coding gene. Diseases associated with FIG4 include Polymicrogyria, Bilateral Temporooccipital and Yunis-Varon Syndrome. Among its related pathways are Metabolism and PI Metabolism. GO annotations related to this gene include phosphatidylinositol-3-phosphatase activity and phosphatidylinositol bisphosphate phosphatase activity.
UniProtKB/Swiss-Prot for FIG4 Gene
-
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIG4 Gene
Genomics for FIG4 Gene
Regulatory Elements for FIG4 Gene
Enhancers for FIG4 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around FIG4 on UCSC Golden Path with GeneCards custom track
Promoters for FIG4 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around FIG4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FIG4 Gene
- Chromosome:
- 6
- Start:
- 109,691,221 bp from pter
- End:
- 109,825,431 bp from pter
- Size:
- 134,211 bases
- Orientation:
- Plus strand
Genomic View for FIG4 Gene
Genes around FIG4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q21 by Ensembl
- 6q21 by Entrez Gene
- 6q21 by HGNC
FIG4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FIG4 Gene
Proteins for FIG4 Gene
-
Protein details for FIG4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92562-FIG4_HUMAN
- Recommended name:
- Polyphosphoinositide phosphatase
- Protein Accession:
- Q92562
- Q53H49
- Q5TCS6
Protein attributes for FIG4 Gene
- Size:
- 907 amino acids
- Molecular mass:
- 103635 Da
- Quaternary structure:
-
- Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold.
- SequenceCaution:
-
- Sequence=BAA13403.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for FIG4 Gene
Post-translational modifications for FIG4 Gene
Other Protein References for FIG4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FIG4
- Abcam antibodies for FIG4
- Invitrogen Antibodies for FIG4
- antibodies-online Antibodies for FIG4: See all 74
- GeneTex FIG4 antibody for FIG4
-
Santa Cruz Biotechnology (SCBT) Antibodies for FIG4
Protein Products
-
OriGene Purified Proteins for FIG4
- Search Origene for MassSpec and Protein Over-expression Lysates for FIG4
- Origene Custom Protein Services for FIG4
- Search GeneTex for Proteins for FIG4
- Abcam proteins for FIG4
Assay Products
Domains & Families for FIG4 Gene
Gene Families for FIG4 Gene
Protein Domains for FIG4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FIG4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92562- Domain:
-
- Contains 1 SAC domain.
Function for FIG4 Gene
Molecular function for FIG4 Gene
- UniProtKB/Swiss-Prot Function:
- The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Enzyme Numbers (IUBMB) for FIG4 Gene
- EC 3.1.3.36 63
- EC 3.1.3 63
- EC 3.1.3.- 4
Phenotypes for FIG4 Gene
- MGI mutant phenotypes for FIG4:
-
inferred from 2 alleles
- mortality/aging
- behavior/neurological phenotype
- immune system phenotype
- cardiovascular system phenotype
- integument phenotype
- growth/size/body region phenotype
- hematopoietic system phenotype
- nervous system phenotype
- muscle phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- pigmentation phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for FIG4:
Animal Model Products
-
Taconic Biosciences Mouse Models for FIG4
-
ViGene Biosciences lentiviral particle packaged cDNA for FIG4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FIG4 gene
- Search ViGene Biosciences for FIG4
CRISPR Products
-
OriGene CRISPR knockouts for FIG4
-
Santa Cruz Biotechnology (SCBT) CRISPR for FIG4
- GenScript: Design CRISPR guide RNA sequences for FIG4
miRNA for FIG4 Gene
- miRTarBase miRNAs that target FIG4
-
- hsa-mir-335-5p (MIRT019027)
- hsa-mir-1-3p (MIRT024087)
- hsa-mir-26b-5p (MIRT030214)
- hsa-mir-5089-5p (MIRT519305)
- hsa-mir-7151-3p (MIRT519306)
- hsa-mir-6807-5p (MIRT519307)
- hsa-mir-5095 (MIRT519308)
- hsa-mir-4252 (MIRT519309)
- hsa-mir-6889-3p (MIRT519310)
- hsa-mir-6506-5p (MIRT519311)
- hsa-mir-619-5p (MIRT519312)
- hsa-mir-6849-3p (MIRT519313)
- hsa-mir-6504-3p (MIRT519314)
- hsa-mir-4438 (MIRT519315)
- hsa-mir-6876-5p (MIRT552226)
- hsa-mir-4476 (MIRT552227)
- hsa-mir-3941 (MIRT607142)
- hsa-mir-4789-3p (MIRT607143)
- hsa-mir-603 (MIRT607144)
- hsa-mir-362-3p (MIRT607145)
- hsa-mir-329-3p (MIRT607146)
- hsa-mir-8485 (MIRT607147)
- hsa-mir-377-3p (MIRT608492)
- hsa-mir-6884-3p (MIRT608493)
- hsa-mir-744-3p (MIRT627007)
- hsa-mir-106a-3p (MIRT627008)
- hsa-mir-4423-5p (MIRT627009)
- hsa-mir-6501-5p (MIRT627010)
- hsa-mir-4430 (MIRT627011)
- hsa-mir-3652 (MIRT627012)
- hsa-mir-122-5p (MIRT627013)
- hsa-mir-504-3p (MIRT627014)
- hsa-mir-3135b (MIRT627015)
- hsa-mir-454-3p (MIRT627016)
- hsa-mir-4295 (MIRT627017)
- hsa-mir-3666 (MIRT627018)
- hsa-mir-301b-3p (MIRT627019)
- hsa-mir-301a-3p (MIRT627020)
- hsa-mir-130b-3p (MIRT627021)
- hsa-mir-130a-3p (MIRT627022)
- hsa-mir-498 (MIRT638022)
- hsa-mir-4279 (MIRT638023)
- hsa-mir-6778-3p (MIRT638024)
- hsa-mir-1976 (MIRT638025)
- hsa-mir-3653-5p (MIRT638026)
- hsa-mir-325 (MIRT638027)
- hsa-mir-6747-3p (MIRT638028)
- hsa-mir-6727-3p (MIRT638029)
- hsa-mir-4722-3p (MIRT638030)
- hsa-mir-6809-3p (MIRT715157)
- hsa-mir-6833-3p (MIRT715158)
- hsa-mir-4768-5p (MIRT715159)
- hsa-mir-6873-3p (MIRT715160)
- hsa-mir-4778-3p (MIRT715161)
- hsa-mir-6787-3p (MIRT715162)
- hsa-mir-1284 (MIRT715163)
- hsa-mir-545-3p (MIRT715164)
miRNA Products
- Search ViGene Biosciences for FIG4
Clone Products
- OriGene clones in human for FIG4
- OriGene ORF clones in human,mouse,rat for FIG4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for FIG4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FIG4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FIG4 gene
Flow Cytometry Products
No data available for Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FIG4 Gene
Localization for FIG4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FIG4 Gene
- Endosome membrane. Note=Localization requires VAC14 and PIKFYVE.
| Compartment | Confidence |
|---|---|
| endosome | 5 |
| golgi apparatus | 5 |
| endoplasmic reticulum | 3 |
| cytosol | 2 |
| lysosome | 2 |
| nucleus | 2 |
| vacuole | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
No data available for Gene Ontology (GO) - Cellular Components for FIG4 Gene
Pathways & Interactions for FIG4 Gene
More details on SuperPathways for FIG4| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | PI Metabolism |
.57
|
|
| 2 | Metabolism |
.38
|
|
| 3 | Glycerophospholipid biosynthesis | ||
| 4 | Inositol phosphate metabolism (KEGG) |
Pathways by source for FIG4 Gene
2 BioSystems pathways for FIG4 Gene
7 Reactome pathways for FIG4 Gene
Interacting Proteins for FIG4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006644 | phospholipid metabolic process | TAS | -- |
| GO:0007033 | vacuole organization | IEA | -- |
| GO:0010976 | positive regulation of neuron projection development | IEA | -- |
| GO:0016311 | dephosphorylation | IEA | -- |
| GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process | TAS | -- |
No data available for SIGNOR curated interactions for FIG4 Gene
Transcripts for FIG4 Gene
mRNA/cDNA for FIG4 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (161) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FIG4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FIG4
-
Santa Cruz Biotechnology (SCBT) CRISPR for FIG4
- GenScript: Design CRISPR guide RNA sequences for FIG4
miRNA Products
- Search ViGene Biosciences for FIG4
Clone Products
- OriGene clones in human for FIG4
- OriGene ORF clones in human,mouse,rat for FIG4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FIG4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
- Nucleus Pulposus
- Primitive Streak (Early Embryonic Tissues)
This gene is overexpressed in Pancreatic juice (15.7), Bone (15.3), and Platelet (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FIG4 Gene
SOURCE GeneReport for Unigene cluster for FIG4 Gene Hs.529959
Primer Products
-
OriGene qPCR primer pairs for FIG4
-
OriGene qPCR primer pairs and template standards for FIG4
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FIG4 Gene
Orthologs for FIG4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | FIG4 35 |
|
||
| FIG4 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | FIG4 35 |
|
||
| FIG4 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Fig4 35 |
|
||
| Fig4 16 |
|
||||
| Fig4 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | FIG4 35 |
|
||
| FIG4 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Fig4 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FIG4 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FIG4 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FIG4 35 |
|
||
| FIG4 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | FIG4 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fig4 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fig4 35 |
|
||
| FIG4 (1 of 2) 36 |
|
OneToMany | |||
| FIG4 (2 of 2) 36 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004477 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG17840 35 |
|
||
| CG17840 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | C34B7.2 36 |
|
OneToOne | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADL195C 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E02113g 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FIG4 35 |
|
||
| FIG4 36 |
|
OneToOne | |||
| FIG4 38 |
|
|
|||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU08689 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1093.03 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for FIG4:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FIG4 Gene
No data available for Paralogs for FIG4 Gene
Variants for FIG4 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2295837 | - | 109,743,725(+) | ACCAG(A/T)TGTTC | reference, missense | |
| rs9885672 | - | 109,786,314(+) | TGCTG(C/T)GAACT | reference, missense | |
| rs121908287 | Charcot-Marie-Tooth disease 4J (CMT4J) | 109,715,133(+) | GAAGA(C/T)TGATA | reference, missense | |
| VAR_054831 | - | ||||
| VAR_054832 | Amyotrophic lateral sclerosis 11 (ALS11) |
Residual Variation Intolerance Score:
5.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.35;
88.40% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FIG4 Gene
- Human Gene Mutation Database (HGMD)
- FIG4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIG4 Gene
Disorders for FIG4 Gene
(18) MalaCards diseases for FIG4 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| polymicrogyria, bilateral temporooccipital |
|
|
| yunis-varon syndrome |
|
|
| charcot-marie-tooth disease, type 4j |
|
|
| amyotrophic lateral sclerosis 11 |
|
|
| charcot-marie-tooth neuropathy type 4j |
|
|
Search FIG4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FIG4_HUMAN- Amyotrophic lateral sclerosis 11 (ALS11) [MIM:612577]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:19118816}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Charcot-Marie-Tooth disease 4J (CMT4J) [MIM:611228]: A recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. {ECO:0000269 PubMed:17572665, ECO:0000269 PubMed:21705420}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Polymicrogyria, bilateral temporooccipital (BTOP) [MIM:612691]: A disease characterized by temporo-occipital polymicrogyria, psychiatric manifestations, and epilepsy. {ECO:0000269 PubMed:24598713}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Yunis-Varon syndrome (YVS) [MIM:216340]: A severe autosomal recessive disorder characterized by skeletal defects, including cleidocranial dysplasia and digital anomalies, and severe neurologic involvement with neuronal loss. Enlarged cytoplasmic vacuoles are found in neurons, muscle, and cartilage. The disorder is usually lethal in infancy. {ECO:0000269 PubMed:23623387}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for FIG4
No data available for Genatlas for FIG4 Gene
Publications for FIG4 Gene
- Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. (PMID: 17572665) Chow C.Y. … Meisler M.H. (Nature 2007) 2 3 4 67
- Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase. (PMID: 11274189) Minagawa T. … Takenawa T. (J. Biol. Chem. 2001) 2 3
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3
- FIG4 is a hepatitis C virus particle-bound protein implicated in virion morphogenesis and infectivity with cholesteryl ester modulation potential. (PMID: 26519381) Cottarel J. … Parent R. (J. Gen. Virol. 2016) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
Products for FIG4 Gene
- Browse R&D Systems for Antibodies
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- Origene Custom Protein Services for FIG4
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for FIG4
- Browse OriGene Inhibitory RNA Products For FIG4
- OriGene qPCR primer pairs for FIG4
- OriGene qPCR primer pairs and template standards for FIG4
- OriGene CRISPR knockouts for FIG4
- OriGene clones in human for FIG4
- OriGene ORF clones in human,mouse,rat for FIG4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for FIG4
- GenScript Custom Assay Services for FIG4
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- GenScript: Design CRISPR guide RNA sequences for FIG4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FIG4
- Novus Biologicals Antibodies for FIG4
- Novus Biologicals proteins and lysates for FIG4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FIG4
- Abcam proteins for FIG4
- Search for Assays for FIG4 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Taconic Biosciences Mouse Models for FIG4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- ViGene Biosciences adenoviral particle packaged cDNA for FIG4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FIG4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FIG4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FIG4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FIG4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FIG4 gene
- Search ViGene Biosciences for FIG4
- Search ViGene Biosciences for FIG4
- Santa Cruz Biotechnology (SCBT) Antibodies for FIG4
- Search Santa Cruz Biotechnology (SCBT) for FIG4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FIG4
Sources for FIG4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
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