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Aliases for FICD Gene

Aliases for FICD Gene

  • FIC Domain Containing 2 3
  • Huntingtin Interacting Protein 13 2 3
  • Huntingtin-Interacting Protein 13 3 4
  • Huntingtin-Interacting Protein E 3 4
  • FIC Domain-Containing Protein 3 4
  • Huntingtin Yeast Partner E 3 4
  • AMPylator FICD 3 4
  • HIP-13 3 4
  • HIP13 3 4
  • HYPE 3 4
  • Fic S-Phase Protein Cell Division Homolog (E. Coli) 2
  • Adenosine Monophosphate-Protein Transferase FICD 3
  • Fic S-Phase Protein Cell Division Homolog 3
  • Huntingtin Interacting Protein E 3
  • Huntingtin Interactor Protein E 3
  • EC 2.7.7.n1 4
  • UNQ3041 3

External Ids for FICD Gene

Summaries for FICD Gene

GeneCards Summary for FICD Gene

FICD (FIC Domain Containing) is a Protein Coding gene. GO annotations related to this gene include protein adenylyltransferase activity.

UniProtKB/Swiss-Prot for FICD Gene

  • Adenylyltransferase that mediates the addition of adenosine 5-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FICD Gene

Genomics for FICD Gene

Genomic Location for FICD Gene

Start:
108,515,185 bp from pter
End:
108,525,837 bp from pter
Size:
10,653 bases
Orientation:
Plus strand

Genomic View for FICD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FICD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FICD Gene

Regulatory Elements for FICD Gene

Proteins for FICD Gene

  • Protein details for FICD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVA6-FICD_HUMAN
    Recommended name:
    Adenosine monophosphate-protein transferase FICD
    Protein Accession:
    Q9BVA6
    Secondary Accessions:
    • O75406

    Protein attributes for FICD Gene

    Size:
    458 amino acids
    Molecular mass:
    51778 Da
    Quaternary structure:
    • Interacts with HD.

    Three dimensional structures from OCA and Proteopedia for FICD Gene

neXtProt entry for FICD Gene

Proteomics data for FICD Gene at MOPED

Post-translational modifications for FICD Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr168

Other Protein References for FICD Gene

No data available for DME Specific Peptides for FICD Gene

Domains for FICD Gene

Protein Domains for FICD Gene

UniProtKB/Swiss-Prot:

FICD_HUMAN
Domain:
  • The fido domain mediates the adenylyltransferase activity:
    • Q9BVA6
  • Contains 1 fido domain.:
    • Q9BVA6
Family:
  • Belongs to the fic family.:
    • Q9BVA6
Similarity:
  • Contains 2 TPR repeats.:
    • Q9BVA6
genes like me logo Genes that share domains with FICD: view

No data available for Gene Families for FICD Gene

Function for FICD Gene

Molecular function for FICD Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + [protein] = diphosphate + [protein]-AMP.
UniProtKB/Swiss-Prot EnzymeRegulation: Adenylyltransferase activity is inhibited by the inhibitory helix present at the N-terminus: Glu-234 binds ATP and competes with ATP-binding at Arg-374, thereby preventing adenylyltransferase activity. Activation dissociates ATP-binding from Glu-234, allowing ordered binding of the entire ATP moiety with the alpha-phosphate in an orientation that is productive for accepting an incoming target hydroxyl side chain.
UniProtKB/Swiss-Prot Function: Adenylyltransferase that mediates the addition of adenosine 5-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified.

Enzyme Numbers (IUBMB) for FICD Gene

Gene Ontology (GO) - Molecular Function for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0070733 protein adenylyltransferase activity IDA 19362538
genes like me logo Genes that share ontologies with FICD: view

miRNA for FICD Gene

miRTarBase miRNAs that target FICD

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FICD Gene

Localization for FICD Gene

Subcellular locations from UniProtKB/Swiss-Prot for FICD Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FICD Gene COMPARTMENTS Subcellular localization image for FICD gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FICD: view

Pathways for FICD Gene

SuperPathways for FICD Gene

No Data Available

Interacting Proteins for FICD Gene

Gene Ontology (GO) - Biological Process for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018117 protein adenylylation IDA 22266942
GO:0034260 negative regulation of GTPase activity TAS 19362538
genes like me logo Genes that share ontologies with FICD: view

No data available for Pathways by source for FICD Gene

Transcripts for FICD Gene

Unigene Clusters for FICD Gene

FIC domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FICD Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c
SP1: - -
SP2: -
SP3:

Relevant External Links for FICD Gene

GeneLoc Exon Structure for
FICD
ECgene alternative splicing isoforms for
FICD

Expression for FICD Gene

mRNA expression in normal human tissues for FICD Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FICD Gene

SOURCE GeneReport for Unigene cluster for FICD Gene Hs.661891

mRNA Expression by UniProt/SwissProt for FICD Gene

Q9BVA6-FICD_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with FICD: view

Orthologs for FICD Gene

This gene was present in the common ancestor of animals.

Orthologs for FICD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FICD 36
  • 99.13 (n)
  • 99.34 (a)
FICD 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FICD 36
  • 88.06 (n)
  • 90.83 (a)
FICD 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FICD 36
  • 88.72 (n)
  • 94.1 (a)
FICD 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ficd 36
  • 86.61 (n)
  • 89.52 (a)
Ficd 16
Ficd 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FICD 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FICD 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ficd 36
  • 85.66 (n)
  • 89.96 (a)
chicken
(Gallus gallus)
Aves FICD 36
  • 74.93 (n)
  • 81.42 (a)
FICD 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FICD 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ficd 36
  • 67.72 (n)
  • 75.34 (a)
zebrafish
(Danio rerio)
Actinopterygii ficd 36
  • 68.14 (n)
  • 73.15 (a)
ficd 37
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009578 36
  • 58.89 (n)
  • 52.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fic 36
  • 57.39 (n)
  • 55.36 (a)
l(2)k11101 37
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fic-1 36
  • 46.88 (n)
  • 45.4 (a)
fic-1 37
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 52 (a)
OneToOne
Species with no ortholog for FICD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FICD Gene

ENSEMBL:
Gene Tree for FICD (if available)
TreeFam:
Gene Tree for FICD (if available)

Paralogs for FICD Gene

No data available for Paralogs for FICD Gene

Variants for FICD Gene

Sequence variations from dbSNP and Humsavar for FICD Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2288380 -- 108,515,667(-) GCTGC(G/T)CGGGT intron-variant
rs2288381 -- 108,515,207(-) TTTCC(C/T)CACTT upstream-variant-2KB
rs2303634 -- 108,517,185(-) GTGGC(A/G)GCATG reference, synonymous-codon
rs5800830 -- 108,519,601(+) TTTAG(-/T)TTTAA utr-variant-3-prime
rs7977789 -- 108,515,980(+) tagct(C/T)ttcct intron-variant

Relevant External Links for FICD Gene

HapMap Linkage Disequilibrium report
FICD

No data available for Structural Variations from Database of Genomic Variants (DGV) for FICD Gene

Disorders for FICD Gene

No disorders were found for FICD Gene.

No data available for UniProtKB/Swiss-Prot for FICD Gene

Publications for FICD Gene

  1. The fic domain: regulation of cell signaling by adenylylation. (PMID: 19362538) Worby C.A. … Dixon J.E. (Mol. Cell 2009) 3 4 23
  2. Huntingtin interacts with a family of WW domain proteins. (PMID: 9700202) Faber P.W. … MacDonald M.E. (Hum. Mol. Genet. 1998) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. (PMID: 22266942) Engel P. … Dehio C. (Nature 2012) 3 4
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for FICD Gene

Sources for FICD Gene

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