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FICD Gene

protein-coding   GIFtS: 45
GCID: GC12P108909

FIC Domain Containing

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FIC Domain Containing1 2     FIC Domain-Containing Protein2 3
Huntingtin Interacting Protein 131 2     Fic S-Phase Protein Cell Division Homolog (E. Coli)1
Huntingtin Yeast Partner E2 3     UNQ30412
Huntingtin-Interacting Protein 132 3     Adenosine Monophosphate-Protein Transferase FICD2
Huntingtin-Interacting Protein E2 3     Fic S-Phase Protein Cell Division Homolog2
HIP-132 3     Huntingtin Interacting Protein E2
HIP132 3     Huntingtin Interactor Protein E2
HYPE2 3     EC 2.7.7.n13
AMPylator FICD2 3     

External Ids:    HGNC: 184161   Entrez Gene: 111532   Ensembl: ENSG000001988557   UniProtKB: Q9BVA63   

Export aliases for FICD gene to outside databases

Previous GC identifers: GC12P107433 GC12P105973


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FICD Gene:
FICD (FIC domain containing) is a protein-coding gene. GO annotations related to this gene include protein adenylyltransferase activity.

UniProtKB/Swiss-Prot: FICD_HUMAN, Q9BVA6
Function: Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues
of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however
unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the FICD gene promoter:
         GATA-3   p53   HOXA3   XBP-1   NF-kappaB   POU3F2   GATA-2   GATA-1   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFICD promoter sequence
   Search Chromatin IP Primers for FICD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FICD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q24.1

FICD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FICD gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P108909:  view genomic region     (about GC identifiers)

Start:
108,908,962 bp from pter      End:
108,919,614 bp from pter
Size:
10,653 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FICD_HUMAN, Q9BVA6 (See protein sequence)
Recommended Name: Adenosine monophosphate-protein transferase FICD  
Size: 458 amino acids; 51778 Da
Subunit: Interacts with HD
Secondary accessions: O75406

Explore the universe of human proteins at neXtProt for FICD: NX_Q9BVA6

Explore proteomics data for FICD at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr168
  • Modification sites at PhosphoSitePlus

  • See FICD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009007.2  
    ENSEMBL proteins: 
     ENSP00000446479   ENSP00000447379   ENSP00000354421   ENSP00000449989  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003812 Fido
     IPR011990 TPR-like_helical
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q9BVA6

    ProtoNet protein and cluster: Q9BVA6

    1 Blocks protein domain: IPB003812 Filamentation induced by cAMP protein Fic

    UniProtKB/Swiss-Prot: FICD_HUMAN, Q9BVA6
    Domain: The fido domain mediates the adenylyltransferase activity
    Similarity: Belongs to the fic family
    Similarity: Contains 1 fido domain
    Similarity: Contains 2 TPR repeats


    Find genes that share domains with FICD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FICD_HUMAN, Q9BVA6
    Function: Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues
    of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however
    unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified
    Catalytic activity: ATP + [protein] = diphosphate + [protein]-AMP
    Enzyme regulation: Adenylyltransferase activity is inhibited by the inhibitory helix present at the N-terminus:
    Glu-234 binds ATP and competes with ATP-binding at Arg-374, thereby preventing adenylyltransferase activity.
    Activation dissociates ATP-binding from Glu-234, allowing ordered binding of the entire ATP moiety with the
    alpha-phosphate in an orientation that is productive for accepting an incoming target hydroxyl side chain

         Enzyme Number (IUBMB): EC 2.7.7.n11

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0070733protein adenylyltransferase activity IDA19362538
         
    Find genes that share ontologies with FICD           About GenesLikeMe


    Animal Models:
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    hsa-mir-335-5p (MIRT018709), hsa-mir-26b-5p (MIRT029945)

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    2 qRT-PCR Assays for microRNAs that regulate FICD:
    hsa-miR-186 hsa-miR-518f*
    SwitchGear 3'UTR luciferase reporter plasmidFICD 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FICD_HUMAN, Q9BVA6: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    extracellular1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FICD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FICD
    Interactions:

        Search GeneGlobe Interaction Network for FICD

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for FICD (Q9BVA63 ENSP000003544214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428583, ENSP000003471844I2D: score=2 STRING: ENSP00000347184
    ADKENSP000002866214STRING: ENSP00000286621
    YBEYENSP000003296144STRING: ENSP00000329614
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018117protein adenylylation IDA--
    GO:0034259negative regulation of Rho GTPase activity TAS19362538

    Find genes that share ontologies with FICD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FICD



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FICD gene: 
    NM_007076.2  

    Unigene Cluster for FICD:

    FIC domain containing
    Hs.661891  [show with all ESTs]
    Unigene Representative Sequence: BC064629
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552695(uc001tmx.1) ENST00000552758 ENST00000361549 ENST00000549641
    ENST00000546448
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FICD:
    hsa-miR-186 hsa-miR-518f*
    SwitchGear 3'UTR luciferase reporter plasmidFICD 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FICD
      QuantiFast Probe-based Assays in human, mouse, rat FICD

    Additional mRNA sequence: 

    AF049611.1 AK000014.1 AK026074.1 AY358992.1 BC001342.1 BC064629.1 

    4 DOTS entries:

    DT.431297  DT.100732204  DT.40282040  DT.95148053 

    Selected AceView cDNA sequences (see all 76):

    BM558593 BF725082 BX280687 AK000014 CB242173 AI014985 AI636448 BM920643 
    BC001342 BQ014248 AK026074 BX117362 AY358992 BM142316 NM_007076 CA772465 
    BF725081 BX096768 CB158028 CA866516 AF049611 CA772166 CD678145 CD364955 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FICD    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:                          -     -               
    SP2:                          -                     
    SP3:                                                


    ECgene alternative splicing isoforms for FICD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FICD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGCGGGCT
    FICD Expression
    About this image

    FICD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FICD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661891

    UniProtKB/Swiss-Prot: FICD_HUMAN, Q9BVA6
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FICD gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ficd1 , 5 FIC domain containing1, 5 86.61(n)1
    89.52(a)1
      5 (55.55 cM)5
    2316301  NM_001010825.31  NP_001010825.21 
     1137357825 
    chicken
    (Gallus gallus)
    Aves FICD1 FIC domain containing 74.93(n)
    81.42(a)
      416889  XM_415180.4  XP_415180.2 
    lizard
    (Anolis carolinensis)
    Reptilia FICD6
    FIC domain containing
    76(a)
    1 ↔ 1
    GL343913.1(125073-126928)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ficd1 FIC domain containing 67.72(n)
    75.34(a)
      100216031  NM_001142020.1  NP_001135492.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI350952.12   -- 76.15(n)    BI350952.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fic1 Fic domain-containing protein 57.39(n)
    55.36(a)
      33897  NM_135182.1  NP_609026.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fic-11 fic-1 46.88(n)
    45.4(a)
      177990  NM_069635.4  NP_502036.1 


    ENSEMBL Gene Tree for FICD (if available)
    TreeFam Gene Tree for FICD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FICD (see all 192)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs558614381,2
    C--108907195(+) GATAG-/ATAG/ATAGATAG/
    ATAGATAGATAG
    /GATA
    TTTGC
    2 -- us2k1 cds11NA 2
    rs111139651,2
    --108907229(+) atagaC/Tagata 1 -- us2k10--------
    rs1382117151,2
    --108907363(+) TCAAGC/TCACTT 1 -- us2k10--------
    rs1850316581,2
    --108907880(+) TTGCGC/TCTGTA 1 -- us2k10--------
    rs111139661,2
    C,F--108908305(+) CaagaC/Gagaga 1 -- us2k14Minor allele frequency- G:0.07WA CSA EA 242
    rs1489492581,2
    C--108908315(+) GAGAG-/AAAAAA 1 -- us2k10--------
    rs1495990971,2
    C--108908321(+) AAAAAA/GAAAGA 1 -- us2k10--------
    rs111139671,2
    C,F,A--108908410(+) CTGAGG/ATGGGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs111139681,2
    C,F,H--108908451(+) CAGTGA/GGCTGC 1 -- us2k15Minor allele frequency- G:0.01NS EA 540
    rs107461251,2
    C,F,A,H--108908468(+) TCCACT/CGCACT 1 -- us2k1 tfbs311Minor allele frequency- C:0.08NA WA CSA EA 257

    HapMap Linkage Disequilibrium report for FICD (108908962 - 108919614 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FICD: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FICD
    DNA2.0 Custom Variant and Variant Library Synthesis for FICD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FICD gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FICD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Huntingtin interacts with a family of WW domain proteins. (PubMed id 9700202)1, 2, 3 Faber P.W....MacDonald M.E. (Hum. Mol. Genet. 1998)
    2. The fic domain: regulation of cell signaling by adenylylation. (PubMed id 19362538)1, 2, 9 Worby C.A.... Dixon J.E. (Mol. Cell 2009)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. (PubMed id 22266942)2 Engel P.... Dehio C. (Nature 2012)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. (PubMed id 15383276)1 Goehler H....Wanker E.E. (Mol. Cell 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11153 HGNC: 18416 AceView: HYPE Ensembl:ENSG00000198855 euGenes: HUgn11153
    ECgene: FICD H-InvDB: FICD

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FICD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FICD gene:
    Search GeneIP for patents involving FICD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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