FICD Gene
protein-coding GIFtS: 44
GCID: GC12P108909
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|
FIC domain containing
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Aliases
for FICD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FIC Domain Containing1 2 | | FIC Domain-Containing Protein2 3 | | HIP131 2 3 | | UNQ30412 | | HYPE1 2 3 | | Adenosine Monophosphate-Protein Transferase FICD2 | | Huntingtin Yeast Partner E2 3 | | Fic S-Phase Protein Cell Division Homolog2 | | Huntingtin-Interacting Protein 132 3 | | Huntingtin Interacting Protein 132 | | Huntingtin-Interacting Protein E2 3 | | Huntingtin Interacting Protein E2 | | HIP-132 3 | | Huntingtin Interactor Protein E2 | | AMPylator FICD2 3 | | EC 2.7.7.N11 |
Export aliases for FICD gene to outside databasesPrevious GC identifers: GC12P107433 GC12P105973 |
Summaries
for FICD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FICD_HUMAN, Q9BVA6Function: Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues oftarget proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclearwhether it inactivates GTPases in vivo and physiological substrates probably remain to be identified
|
Genomic Views
for FICD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FICD gene promoter:
GATA-3 p53 HOXA3 XBP-1 NF-kappaB POU3F2 GATA-2 GATA-1 STAT3 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FICD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FICD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.1 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q24.1FICD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P108909: view genomic region
(about GC identifiers)
Start:
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108,908,962 bp from pter |
End:
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108,919,614 bp from pter |
Size:
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10,653 bases |
Orientation:
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plus strand |
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Proteins
for FICD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FICD_HUMAN, Q9BVA6 (See
protein sequence)Recommended Name: Adenosine monophosphate-protein transferase FICD Size: 458 amino acids; 51778 Da
Subunit: Interacts with HD
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: O75406Explore the universe of human proteins at neXtProt for FICD: NX_Q9BVA6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BVA6
FICD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009007.2
ENSEMBL proteins: ENSP00000446479 ENSP00000447379 ENSP00000354421 ENSP00000449989
Human Recombinant Protein Products for FICD:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
FICD for ontologies About GeneDecksing
FICD Antibody Products:
Assay Products for FICD: |
Protein
Domains /
Families
for FICD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FICD for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BVA6ProtoNet protein and cluster: Q9BVA6 1 Blocks protein family: IPB003812 Filamentation induced by cAMP protein Fic
UniProtKB/Swiss-Prot: FICD_HUMAN, Q9BVA6Domain: The fido domain mediates the adenylyltransferase activitySimilarity: Belongs to the fic familySimilarity: Contains 1 fido domainSimilarity: Contains 2 TPR repeats |
Function
for FICD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FICD_HUMAN, Q9BVA6Function: Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues oftarget proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclearwhether it inactivates GTPases in vivo and physiological substrates probably remain to be identifiedCatalytic activity: ATP + [protein] = diphosphate + [protein]-AMPEnzyme regulation: Adenylyltransferase activity is inhibited by the inhibitory helix present at the N-terminus: Glu-234binds ATP and competes with ATP-binding at Arg-374, thereby preventing adenylyltransferase activity. Activationdissociates ATP-binding from Glu-234, allowing ordered binding of the entire ATP moiety with the alpha-phosphate in anorientation that is productive for accepting an incoming target hydroxyl side chain Enzyme Number (IUBMB): EC 2.7.7.n11
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0070733 | protein adenylyltransferase activity |
IDA | -- |
FICD for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FICD (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FICD
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FICD (NM_007076) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FICD | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FICD |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FICD |
|
Pathways & Interactions
for FICD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FICD
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for FICD (Q9BVA63 ENSP000003544214) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0018117 | protein adenylylation |
IDA | -- | | GO:0034259 | negative regulation of Rho GTPase activity |
TAS | 19362538 |
FICD for ontologies About GeneDecksing
|
Drugs & Compounds
for FICD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FICD
Search CenterWatch for drugs/clinical trials and news about FICD
|
Transcripts
for FICD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FICD gene: NM_007076.2 Unigene Cluster for FICD: FIC domain containing Hs.661891 [show with all ESTs]Unigene Representative Sequence: BC0646295 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000552695(uc001tmx.1) ENST00000552758 ENST00000361549 ENST00000549641
ENST00000546448
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FICD (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FICD
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FICD (NM_007076) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FICD | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FICD |
Additional cDNA sequence: AF049611.1 AK000014.1 AK026074.1 AY358992.1 BC001342.1 BC064629.1 4 DOTS entries: DT.431297 DT.100732204 DT.40282040 DT.95148053 24/76 AceView cDNA sequences (see all 76): CA772465 BF725081 CB242173 AF049611 AY358992 BM558593 AK026074 AK000014 BC001342 AI014985 CA866516 BM142316 BF725082 BQ014248 BM920643 CB158028 AI636448 NM_007076 BX096768 BX280687 BX117362 AI628601 AI764981 BG114836
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for FICD About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FICD
|
Expression
for FICD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FICD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGCGGGCT
About this image
See FICD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FICD
SOURCE GeneReport for Unigene cluster: Hs.661891
UniProtKB/Swiss-Prot: FICD_HUMAN, Q9BVA6Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for FICD
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FICD
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FICD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FICD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FICD | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FICD |
Orthologs
for FICD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FICD gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for FICD (if available)
TreeFam Gene Tree for FICD (if available) |
Paralogs
for FICD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FICD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FICD (108908962 - 108919614 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FICD: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FICD |
|
Disorders
/ Diseases
for FICD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FICD for disorders About GeneDecksing
1  disease for FICD: About MalaCardsgenital herpes
Export disorders for FICD gene to outside databases
|
Publications
for FICD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FICD gene integrated from 9 sources:
(articles sorted by number of sources associating them with FICD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Huntingtin interacts with a family of WW domain proteins. (PubMed id 9700202)1, 2, 3 Faber P.W....MacDonald M.E. (1998)
- The fic domain: regulation of cell signaling by adenylylation. (PubMed id 19362538)1, 2, 9 Worby C.A....Dixon J.E. (2009)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. (PubMed id 22266942)2 Engel P.... Dehio C. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. (PubMed id 15383276)1 Goehler H....Wanker E.E. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FICD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FICD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FICD gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FICD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FICD | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FICD gene:
Search GeneIP for patents involving FICD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FICD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FICD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FICD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FICD | | | OriGene Protein Over-expression Lysate for FICD | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FICD | | OriGene 3'-UTR Clone for FICD | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FICD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FICD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FICD | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FICD | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FICD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FICD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FICD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FICD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FICD |
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| | | | Search Tocris compounds for FICD |
| |  |  |  |  | | | | |
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 | | | FICD Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FICD |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FICD |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FICD |
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