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Aliases for FIBP Gene

Aliases for FIBP Gene

  • FGF1 Intracellular Binding Protein 2 3 5
  • AFGF Intracellular-Binding Protein 3 4
  • Fibroblast Growth Factor (Acidic) Intracellular Binding Protein 2
  • Acidic Fibroblast Growth Factor Intracellular-Binding Protein 3
  • FGF-1 Intracellular-Binding Protein 4
  • FGFIBP 3
  • FIBP-1 3
  • TROFAS 3

External Ids for FIBP Gene

Previous GeneCards Identifiers for FIBP Gene

  • GC11M068185
  • GC11M067333
  • GC11M065426
  • GC11M065407
  • GC11M065651
  • GC11M061977

Summaries for FIBP Gene

Entrez Gene Summary for FIBP Gene

  • Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FIBP Gene

FIBP (FGF1 Intracellular Binding Protein) is a Protein Coding gene. Diseases associated with FIBP include Learning Disability and Mental Retardation-Hypotonic Facies Syndrome, X-Linked. GO annotations related to this gene include fibroblast growth factor binding.

UniProtKB/Swiss-Prot for FIBP Gene

  • May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).

Gene Wiki entry for FIBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIBP Gene

Genomics for FIBP Gene

Regulatory Elements for FIBP Gene

Enhancers for FIBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065927 1.4 FANTOM5 Ensembl ENCODE 12.4 -39.7 -39688 2.5 HDGF NFRKB THAP11 CBFB SP1 NFIL3 ZNF589 SMARCA4 RCOR2 IKZF1 EIF1AD CST6 FIBP CCDC85B CTSW SART1 FOSL1 CFL1 MUS81 BANF1
GH11F065932 1.2 Ensembl ENCODE 12.3 -43.9 -43876 0.8 CTCF USF1 L3MBTL2 MAX USF2 REST SREBF1 RAD51 GLIS1 ZBTB33 CCDC85B FIBP CTSW FOSL1 SART1 CFL1 MUS81 SNX32 PACS1 ENSG00000255320
GH11F065931 0.9 Ensembl 12.3 -43.2 -43162 0.2 SREBF1 CCDC85B FIBP CTSW FOSL1 SART1 CFL1 MUS81 SNX32 EIF1AD PACS1
GH11F065940 0.5 Ensembl ENCODE 11.7 -53.0 -53038 2.4 HDAC1 ATF1 PKNOX1 CBX3 ARNT TBL1XR1 NFXL1 BMI1 RARA ELK1 CTSW SART1 C11orf68 DRAP1 FOSL1 CCDC85B FIBP EFEMP2 CFL1 BANF1
GH11F065945 1.2 Ensembl ENCODE 11.2 -57.3 -57271 1.3 HDGF PKNOX1 ATF1 ZNF76 SIN3A RARA ZNF121 SCRT2 SP3 ZBTB11 C11orf68 DRAP1 FOSL1 BANF1 EIF1AD CST6 CTSW EFEMP2 CFL1 MUS81
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FIBP on UCSC Golden Path with GeneCards custom track

Promoters for FIBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001769321 -161 1801 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for FIBP Gene

Chromosome:
11
Start:
65,883,740 bp from pter
End:
65,888,539 bp from pter
Size:
4,800 bases
Orientation:
Minus strand

Genomic View for FIBP Gene

Genes around FIBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIBP Gene

Proteins for FIBP Gene

  • Protein details for FIBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43427-FIBP_HUMAN
    Recommended name:
    Acidic fibroblast growth factor intracellular-binding protein
    Protein Accession:
    O43427
    Secondary Accessions:
    • A8K0J7
    • Q27Q85
    • Q6IBQ3
    • Q9HD65

    Protein attributes for FIBP Gene

    Size:
    364 amino acids
    Molecular mass:
    41878 Da
    Quaternary structure:
    • Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.

    Alternative splice isoforms for FIBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FIBP Gene

Post-translational modifications for FIBP Gene

  • Ubiquitination at Lys 245, Lys 251, and Lys 268
  • Modification sites at PhosphoSitePlus

Other Protein References for FIBP Gene

No data available for DME Specific Peptides for FIBP Gene

Domains & Families for FIBP Gene

Protein Domains for FIBP Gene

Suggested Antigen Peptide Sequences for FIBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FIBP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FIBP Gene

Function for FIBP Gene

Molecular function for FIBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).

Gene Ontology (GO) - Molecular Function for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017134 fibroblast growth factor binding IEA,IPI 9806903
genes like me logo Genes that share ontologies with FIBP: view

Phenotypes for FIBP Gene

GenomeRNAi human phenotypes for FIBP:
genes like me logo Genes that share phenotypes with FIBP: view

Animal Model Products

miRNA for FIBP Gene

miRTarBase miRNAs that target FIBP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIBP Gene

Localization for FIBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIBP Gene

Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FIBP Gene COMPARTMENTS Subcellular localization image for FIBP gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 4
cytosol 3

Gene Ontology (GO) - Cellular Components for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9806903
GO:0005739 mitochondrion TAS 9806903
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA,IDA 9806903
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FIBP: view

Pathways & Interactions for FIBP Gene

SuperPathways for FIBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008543 fibroblast growth factor receptor signaling pathway TAS 9806903
GO:0070527 platelet aggregation IMP 23382103
genes like me logo Genes that share ontologies with FIBP: view

No data available for Pathways by source and SIGNOR curated interactions for FIBP Gene

Drugs & Compounds for FIBP Gene

(2) Drugs for FIBP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FIBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FIBP: view

Transcripts for FIBP Gene

Unigene Clusters for FIBP Gene

Fibroblast growth factor (acidic) intracellular binding protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIBP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - -
SP8: - -
SP9: -
SP10: - - -
SP11:
SP12:
SP13: -

ExUns: 11a · 11b · 11c ^ 12
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FIBP Gene

GeneLoc Exon Structure for
FIBP
ECgene alternative splicing isoforms for
FIBP

Expression for FIBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FIBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FIBP Gene

This gene is overexpressed in Brain (15.8), Peripheral blood mononuclear cells (9.7), and Stomach (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FIBP Gene



Protein tissue co-expression partners for FIBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FIBP Gene:

FIBP

SOURCE GeneReport for Unigene cluster for FIBP Gene:

Hs.7768

mRNA Expression by UniProt/SwissProt for FIBP Gene:

O43427-FIBP_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.
genes like me logo Genes that share expression patterns with FIBP: view

Primer Products

No data available for mRNA differential expression in normal tissues for FIBP Gene

Orthologs for FIBP Gene

This gene was present in the common ancestor of animals.

Orthologs for FIBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIBP 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia FIBP 34 35
  • 92.4 (n)
cow
(Bos Taurus)
Mammalia FIBP 34 35
  • 92.06 (n)
oppossum
(Monodelphis domestica)
Mammalia FIBP 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fibp 34 16 35
  • 90.75 (n)
rat
(Rattus norvegicus)
Mammalia Fibp 34
  • 89.08 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fibp 34
  • 68.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3720 34
zebrafish
(Danio rerio)
Actinopterygii fibpb 35 35
  • 71 (a)
OneToMany
fibpa 34 35
  • 69.09 (n)
zgc64086 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002269 34
  • 54.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fibp 36 34 35
  • 53.75 (n)
Species where no ortholog for FIBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FIBP Gene

ENSEMBL:
Gene Tree for FIBP (if available)
TreeFam:
Gene Tree for FIBP (if available)

Paralogs for FIBP Gene

Pseudogenes.org Pseudogenes for FIBP Gene

genes like me logo Genes that share paralogs with FIBP: view

No data available for Paralogs for FIBP Gene

Variants for FIBP Gene

Sequence variations from dbSNP and Humsavar for FIBP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs786204849 Pathogenic 65,885,181(-) ACTCA(C/T)AGATG nc-transcript-variant, reference, stop-gained
rs111732020 -- 65,885,676(+) GACGA(C/G)AGGAG intron-variant
rs111791333 -- 65,887,147(+) ATAGC(C/T)TGGAA intron-variant
rs112021491 -- 65,889,813(+) CGACA(C/T)ATCTG upstream-variant-2KB
rs112280459 -- 65,890,505(+) CACCC(A/G)GAGTG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FIBP Gene

Variant ID Type Subtype PubMed ID
esv2759834 CNV gain 17122850
nsv1159905 CNV duplication 26073780
nsv555215 CNV loss 21841781
nsv832191 CNV loss 17160897
nsv951019 CNV deletion 24416366

Variation tolerance for FIBP Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIBP Gene

Human Gene Mutation Database (HGMD)
FIBP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIBP Gene

Disorders for FIBP Gene

MalaCards: The human disease database

(3) MalaCards diseases for FIBP Gene - From: ClinVar and DISEASES

Disorder Aliases PubMed IDs
learning disability
  • academic skill disorder
mental retardation-hypotonic facies syndrome, x-linked
  • mental retardation-hypotonic facies syndrome, x-linked, 1
coloboma, ocular
  • coloboma, ocular, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards
Search FIBP in MalaCards View complete list of genes associated with diseases

Relevant External Links for FIBP

Genetic Association Database (GAD)
FIBP
Human Genome Epidemiology (HuGE) Navigator
FIBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FIBP
genes like me logo Genes that share disorders with FIBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FIBP Gene

Publications for FIBP Gene

  1. Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein. (PMID: 11104667) Kolpakova E. … Olsnes S. (Biochem. J. 2000) 3 4 22 64
  2. Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor. (PMID: 9806903) Kolpakova E. … Olsnes S. (Biochem. J. 1998) 2 3 4 64
  3. Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. (PMID: 25096995) Xu S. … Chen J. (Mol. Cell Proteomics 2014) 2 3 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FIBP Gene

Sources for FIBP Gene

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