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Aliases for FIBP Gene

Aliases for FIBP Gene

  • Fibroblast Growth Factor (Acidic) Intracellular Binding Protein 2 3
  • FGF-1 Intracellular-Binding Protein 3 4
  • AFGF Intracellular-Binding Protein 3 4
  • Acidic Fibroblast Growth Factor Intracellular-Binding Protein 3
  • FGFIBP 3
  • FIBP-1 3

External Ids for FIBP Gene

Previous GeneCards Identifiers for FIBP Gene

  • GC11M068185
  • GC11M067333
  • GC11M065426
  • GC11M065407
  • GC11M065651
  • GC11M061977

Summaries for FIBP Gene

Entrez Gene Summary for FIBP Gene

  • Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FIBP Gene

FIBP (Fibroblast Growth Factor (Acidic) Intracellular Binding Protein) is a Protein Coding gene. GO annotations related to this gene include fibroblast growth factor binding.

UniProtKB/Swiss-Prot for FIBP Gene

  • May be involved in mitogenic function of FGF1

Gene Wiki entry for FIBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIBP Gene

Genomics for FIBP Gene

Regulatory Elements for FIBP Gene

Genomic Location for FIBP Gene

Start:
65,883,740 bp from pter
End:
65,888,539 bp from pter
Size:
4,800 bases
Orientation:
Minus strand

Genomic View for FIBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FIBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIBP Gene

Proteins for FIBP Gene

  • Protein details for FIBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43427-FIBP_HUMAN
    Recommended name:
    Acidic fibroblast growth factor intracellular-binding protein
    Protein Accession:
    O43427
    Secondary Accessions:
    • A8K0J7
    • Q27Q85
    • Q6IBQ3
    • Q9HD65

    Protein attributes for FIBP Gene

    Size:
    364 amino acids
    Molecular mass:
    41878 Da
    Quaternary structure:
    • Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1

    Alternative splice isoforms for FIBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FIBP Gene

Proteomics data for FIBP Gene at MOPED

Post-translational modifications for FIBP Gene

  • Ubiquitination at Lys245, Lys251, and Lys268
  • Modification sites at PhosphoSitePlus

Other Protein References for FIBP Gene

No data available for DME Specific Peptides for FIBP Gene

Domains for FIBP Gene

Protein Domains for FIBP Gene

Suggested Antigen Peptide Sequences for FIBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FIBP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FIBP Gene

Function for FIBP Gene

Molecular function for FIBP Gene

UniProtKB/Swiss-Prot Function: May be involved in mitogenic function of FGF1

Gene Ontology (GO) - Molecular Function for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017134 fibroblast growth factor binding IPI 9806903
genes like me logo Genes that share ontologies with FIBP: view

miRNA for FIBP Gene

miRTarBase miRNAs that target FIBP

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FIBP Gene

Localization for FIBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIBP Gene

Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FIBP Gene COMPARTMENTS Subcellular localization image for FIBP gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3

Gene Ontology (GO) - Cellular Components for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion TAS 9806903
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IDA 9806903
genes like me logo Genes that share ontologies with FIBP: view

Pathways for FIBP Gene

SuperPathways for FIBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008543 fibroblast growth factor receptor signaling pathway TAS 9806903
GO:0070527 platelet aggregation IMP 23382103
genes like me logo Genes that share ontologies with FIBP: view

No data available for Pathways by source for FIBP Gene

Compounds for FIBP Gene

(4) Novoseek inferred chemical compound relationships for FIBP Gene

Compound -log(P) Hits PubMed IDs
serine 22.6 4
retinoic acid 14.7 1
steroid 0 1
zinc 0 1
genes like me logo Genes that share compounds with FIBP: view

Transcripts for FIBP Gene

Unigene Clusters for FIBP Gene

Fibroblast growth factor (acidic) intracellular binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FIBP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - -
SP8: - -
SP9: -
SP10: - - -
SP11:
SP12:
SP13: -

ExUns: 11a · 11b · 11c ^ 12
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FIBP Gene

GeneLoc Exon Structure for
FIBP
ECgene alternative splicing isoforms for
FIBP

Expression for FIBP Gene

mRNA expression in normal human tissues for FIBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FIBP Gene

SOURCE GeneReport for Unigene cluster for FIBP Gene Hs.7768

mRNA Expression by UniProt/SwissProt for FIBP Gene

O43427-FIBP_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney
genes like me logo Genes that share expressions with FIBP: view

No data available for mRNA differential expression in normal tissues for FIBP Gene

Orthologs for FIBP Gene

This gene was present in the common ancestor of animals.

Orthologs for FIBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIBP 35
  • 99.54 (n)
  • 100 (a)
FIBP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FIBP 35
  • 92.06 (n)
  • 98.88 (a)
FIBP 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FIBP 35
  • 92.4 (n)
  • 98.08 (a)
FIBP 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fibp 35
  • 90.75 (n)
  • 97.25 (a)
Fibp 16
Fibp 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FIBP 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fibp 35
  • 89.08 (n)
  • 95.8 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3720 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fibp 35
  • 68.54 (n)
  • 76.97 (a)
zebrafish
(Danio rerio)
Actinopterygii fibpa 35
  • 69.09 (n)
  • 72.27 (a)
fibpa 36
  • 73 (a)
OneToMany
fibpb 36
  • 71 (a)
OneToMany
fibpb 36
  • 71 (a)
OneToMany
zgc64086 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002269 35
  • 54.79 (n)
  • 45.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fibp 35
  • 53.75 (n)
  • 47.56 (a)
Fibp 36
  • 46 (a)
OneToOne
Fibp 37
  • 45 (a)
Species with no ortholog for FIBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FIBP Gene

ENSEMBL:
Gene Tree for FIBP (if available)
TreeFam:
Gene Tree for FIBP (if available)

Paralogs for FIBP Gene

Pseudogenes.org Pseudogenes for FIBP Gene

genes like me logo Genes that share paralogs with FIBP: view

No data available for Paralogs for FIBP Gene

Variants for FIBP Gene

Sequence variations from dbSNP and Humsavar for FIBP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs568617 -- 65,885,771(+) TGCCT(C/T)AAGTC intron-variant
rs641018 -- 65,887,922(-) ACCCT(C/G)TGGGA intron-variant
rs658938 -- 65,884,359(+) GGCAA(A/G)GCCAA intron-variant
rs663491 -- 65,886,252(+) TTGGG(C/G)TAGGG intron-variant
rs677835 -- 65,887,122(+) GGTCA(C/T)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FIBP Gene

Variant ID Type Subtype PubMed ID
nsv897736 CNV Loss 21882294
dgv393e1 CNV Complex 17122850
dgv1185n71 CNV Loss 21882294
nsv897764 CNV Loss 21882294
nsv832191 CNV Loss 17160897

Relevant External Links for FIBP Gene

HapMap Linkage Disequilibrium report
FIBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIBP Gene

Disorders for FIBP Gene

(8) Novoseek inferred disease relationships for FIBP Gene

Disease -log(P) Hits PubMed IDs
uremic syndrome 35.9 1
carcinoma squamous cell 24 2
tumors 23.7 5
cancer 0.906 2
breast cancer 0.817 1

Relevant External Links for FIBP

Genetic Association Database (GAD)
FIBP
Human Genome Epidemiology (HuGE) Navigator
FIBP
genes like me logo Genes that share disorders with FIBP: view

No data available for UniProtKB/Swiss-Prot for FIBP Gene

Publications for FIBP Gene

  1. Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein. (PMID: 11104667) Kolpakova E. … Olsnes S. (Biochem. J. 2000) 3 4 23
  2. Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor. (PMID: 9806903) Kolpakova E. … Olsnes S. (Biochem. J. 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. (PMID: 25096995) Xu S. … Chen J. (Mol. Cell Proteomics 2014) 2 3

Products for FIBP Gene

Sources for FIBP Gene

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