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Aliases for FIBIN Gene

Aliases for FIBIN Gene

  • Fin Bud Initiation Factor Homolog (Zebrafish) 2 3 5

External Ids for FIBIN Gene

Previous GeneCards Identifiers for FIBIN Gene

  • GC11P026713

Summaries for FIBIN Gene

GeneCards Summary for FIBIN Gene

FIBIN (Fin Bud Initiation Factor Homolog (Zebrafish)) is a Protein Coding gene. Diseases associated with FIBIN include Wilson-Turner X-Linked Mental Retardation Syndrome.

Additional gene information for FIBIN Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIBIN Gene

Genomics for FIBIN Gene

GeneHancer (GH) Regulatory Elements for FIBIN Gene

Promoters and enhancers for FIBIN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I026993 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +0.8 846 3.1 MAZ RXRA ZNF189 ZIC2 RAD21 ZNF335 ZBTB48 PATZ1 ZNF600 ZBTB12 FIBIN GC11P026998
GH11I026991 Enhancer 0.7 Ensembl ENCODE 550.8 -1.9 -1891 1.2 JUND GLIS1 CEBPB FOS FIBIN PIR40698
GH11I026944 Enhancer 1 FANTOM5 Ensembl ENCODE 10.8 -47.3 -47298 4 ATF4 JUND RXRA ATF3 POLR2A CEBPG FOS NR2F2 FIBIN GC11P026950 PIR54616 PIR32216
GH11I027054 Enhancer 0.9 ENCODE 10.6 +61.4 61351 1.2 FOXA2 MLX ARID4B SIN3A ZNF48 ETS1 TCF12 RXRA PPARG NFIL3 GC11P027055 GC11P027056 GC11P027057 GC11P027058 GC11P027059 GC11P027060 GC11P027061 GC11P027062 GC11P027063 GC11P027064
GH11I026949 Enhancer 0.6 ENCODE 11.2 -43.5 -43512 1.2 FOXA2 RXRA MAX REST RAD21 YY1 JUND ATF3 HNF4A FOS GC11P026950 PIR32216 FIBIN PIR40698
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FIBIN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FIBIN gene promoter:

Genomic Locations for FIBIN Gene

Genomic Locations for FIBIN Gene
chr11:26,994,081-26,997,087
(GRCh38/hg38)
Size:
3,007 bases
Orientation:
Plus strand
chr11:27,015,628-27,018,634
(GRCh37/hg19)

Genomic View for FIBIN Gene

Genes around FIBIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIBIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIBIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIBIN Gene

Proteins for FIBIN Gene

  • Protein details for FIBIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAL6-FIBIN_HUMAN
    Recommended name:
    Fin bud initiation factor homolog
    Protein Accession:
    Q8TAL6

    Protein attributes for FIBIN Gene

    Size:
    211 amino acids
    Molecular mass:
    24273 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Seems to also exist as monomers.

neXtProt entry for FIBIN Gene

Post-translational modifications for FIBIN Gene

Other Protein References for FIBIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FIBIN Gene

Domains & Families for FIBIN Gene

Gene Families for FIBIN Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for FIBIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FIBIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAL6

UniProtKB/Swiss-Prot:

FIBIN_HUMAN :
  • Belongs to the FIBIN family.
Family:
  • Belongs to the FIBIN family.
genes like me logo Genes that share domains with FIBIN: view

Function for FIBIN Gene

Gene Ontology (GO) - Molecular Function for FIBIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with FIBIN: view

Phenotypes for FIBIN Gene

genes like me logo Genes that share phenotypes with FIBIN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIBIN Gene

Localization for FIBIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIBIN Gene

Secreted. Golgi apparatus. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIBIN gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for FIBIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with FIBIN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FIBIN Gene

Pathways & Interactions for FIBIN Gene

SuperPathways for FIBIN Gene

No Data Available

Interacting Proteins for FIBIN Gene

Gene Ontology (GO) - Biological Process for FIBIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0010042 response to manganese ion IEA --
GO:0071548 response to dexamethasone IEA --
GO:1904627 response to phorbol 13-acetate 12-myristate IEA --
genes like me logo Genes that share ontologies with FIBIN: view

No data available for Pathways by source and SIGNOR curated interactions for FIBIN Gene

Drugs & Compounds for FIBIN Gene

No Compound Related Data Available

Transcripts for FIBIN Gene

mRNA/cDNA for FIBIN Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(114) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FIBIN Gene

Fin bud initiation factor homolog (zebrafish):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIBIN Gene

No ASD Table

Relevant External Links for FIBIN Gene

GeneLoc Exon Structure for
FIBIN
ECgene alternative splicing isoforms for
FIBIN

Expression for FIBIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FIBIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FIBIN Gene

This gene is overexpressed in Artery - Aorta (x7.7) and Nerve - Tibial (x5.7).

Protein differential expression in normal tissues from HIPED for FIBIN Gene

This gene is overexpressed in Fetal gut (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FIBIN Gene



Protein tissue co-expression partners for FIBIN Gene

NURSA nuclear receptor signaling pathways regulating expression of FIBIN Gene:

FIBIN

SOURCE GeneReport for Unigene cluster for FIBIN Gene:

Hs.712718

Evidence on tissue expression from TISSUES for FIBIN Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with FIBIN: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FIBIN Gene

Orthologs for FIBIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for FIBIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIBIN 34 33
  • 99.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FIBIN 34 33
  • 91.79 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fibin 16 34 33
  • 89.52 (n)
rat
(Rattus norvegicus)
Mammalia Fibin 33
  • 88.73 (n)
dog
(Canis familiaris)
Mammalia FIBIN 34 33
  • 78.04 (n)
OneToOne
chicken
(Gallus gallus)
Aves FIBIN 34 33
  • 74.06 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FIBIN 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fibin 33
  • 69.62 (n)
zebrafish
(Danio rerio)
Actinopterygii fibinb 34
  • 61 (a)
OneToMany
fibina 34
  • 51 (a)
OneToMany
sbcb374 33
Species where no ortholog for FIBIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FIBIN Gene

ENSEMBL:
Gene Tree for FIBIN (if available)
TreeFam:
Gene Tree for FIBIN (if available)

Paralogs for FIBIN Gene

No data available for Paralogs for FIBIN Gene

Variants for FIBIN Gene

Sequence variations from dbSNP and Humsavar for FIBIN Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000876451 -- 26,994,324(+) G/A 5_prime_UTR_variant
rs1001328568 -- 26,994,022(+) C/T upstream_transcript_variant
rs1001679473 -- 26,992,097(+) G/A upstream_transcript_variant
rs1001766556 -- 26,995,203(+) C/T 3_prime_UTR_variant
rs1002218994 -- 26,994,832(+) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for FIBIN Gene

Variant ID Type Subtype PubMed ID
dgv1727n54 CNV gain 21841781
esv3625759 CNV gain 21293372
esv3625760 CNV gain 21293372

Variation tolerance for FIBIN Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FIBIN Gene

Human Gene Mutation Database (HGMD)
FIBIN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIBIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIBIN Gene

Disorders for FIBIN Gene

MalaCards: The human disease database

(1) MalaCards diseases for FIBIN Gene - From: DISEASES

Disorder Aliases PubMed IDs
wilson-turner x-linked mental retardation syndrome
  • wts
- elite association - COSMIC cancer census association via MalaCards
Search FIBIN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FIBIN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FIBIN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FIBIN Gene

Publications for FIBIN Gene

  1. Fibin, a novel secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish. (PMID: 17196583) Wakahara T … Itoh N (Developmental biology 2007) 2 3 4 58
  2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. Characterization of the expression, promoter activity and molecular architecture of fibin. (PMID: 21615908) Lakner J … Schöneberg T (BMC biochemistry 2011) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for FIBIN Gene

Sources for FIBIN Gene

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