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FIBIN Gene

protein-coding   GIFtS: 41
GCID: GC11P026973

Fin Bud Initiation Factor Homolog (Zebrafish)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fin Bud Initiation Factor Homolog (Zebrafish)1 2
Fin Bud Initiation Factor Homolog2

External Ids:    HGNC: 337471   Entrez Gene: 3877582   Ensembl: ENSG000001769717   UniProtKB: Q8TAL63   

Export aliases for FIBIN gene to outside databases

Previous GC identifer: GC11P026713


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FIBIN Gene:
FIBIN (fin bud initiation factor homolog (zebrafish)) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FIBIN gene promoter:
         AhR   HOXA3   AML1a   MyoD   MIF-1   GATA-1   PPAR-alpha   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFIBIN promoter sequence
   Search Chromatin IP Primers for FIBIN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FIBIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.2   Ensembl cytogenetic band:  11p14.2   HGNC cytogenetic band: 11p14.2

FIBIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FIBIN gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P026973:  view genomic region     (about GC identifiers)

Start:
27,015,628 bp from pter      End:
27,018,634 bp from pter
Size:
3,007 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FIBIN_HUMAN, Q8TAL6 (See protein sequence)
Recommended Name: Fin bud initiation factor homolog precursor  
Size: 211 amino acids; 24273 Da
Subunit: Homodimer; disulfide-linked. Seems to also exist as monomers

Explore the universe of human proteins at neXtProt for FIBIN: NX_Q8TAL6

Explore proteomics data for FIBIN at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn30

  • See FIBIN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_976249.1  
    ENSEMBL proteins: 
     ENSP00000321962  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026772 Fibin

    Graphical View of Domain Structure for InterPro Entry Q8TAL6

    ProtoNet protein and cluster: Q8TAL6

    UniProtKB/Swiss-Prot: FIBIN_HUMAN, Q8TAL6
    Similarity: Belongs to the FIBIN family


    Find genes that share domains with FIBIN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for FIBIN:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FIBIN
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FIBIN_HUMAN, Q8TAL6: Secreted (By similarity). Golgi apparatus (By similarity). Endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3
    golgi apparatus2
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--

    Find genes that share ontologies with FIBIN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FIBIN
    Interactions:

        Search GeneGlobe Interaction Network for FIBIN

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FIBIN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FIBIN gene: 
    NM_203371.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000318627(uc001mrd.3)
    miRNA
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    hsa-miR-892b hsa-miR-106a hsa-miR-575 hsa-miR-16-1* hsa-miR-301a hsa-miR-519a hsa-miR-570 hsa-miR-93
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    Selected AceView cDNA sequences (see all 114):

    BM985356 AI056404 CN483441 NM_203371 AI755024 AW452123 AI250789 CF528458 
    AI200161 AI383659 N41425 CD558972 CD515579 AI188511 BU753976 CR602973 
    BX329127 AI139466 BE501430 BX110467 AI937190 N26312 CN480229 AA701241 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FIBIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATACTGGC
    FIBIN Expression
    About this image


    FIBIN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Lung (Respiratory System)
             Trachea
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Limb (Muscoskeletal System)
             Autopod
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    FIBIN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FIBIN Protein Expression
        Custom PCR Arrays for FIBIN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIBIN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FIBIN gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fibin1 , 5 fin bud initiation factor homolog (zebrafish)1, 5 89.52(n)1
    93.81(a)1
      2 (56.70 cM)5
    676061  NM_026271.11  NP_080547.11 
     1103609175 
    chicken
    (Gallus gallus)
    Aves FIBIN1 fin bud initiation factor homolog (zebrafish) 74.06(n)
    73.89(a)
      426933  NM_001277594.1  NP_001264523.1 
    lizard
    (Anolis carolinensis)
    Reptilia FIBIN6
    fin bud initiation factor homolog (zebrafish)
    63(a)
    1 ↔ 1
    GL343240.1(1040514-1041197)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fibin1 fin bud initiation factor homolog 69.62(n)
    67.49(a)
      100379798  XM_002938894.2  XP_002938940.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb3742 sbcb374 77.57(n)   321227  57054714 


    ENSEMBL Gene Tree for FIBIN (if available)
    TreeFam Gene Tree for FIBIN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FIBIN (see all 110)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406360911,2
    --27013657(+) AAGAAA/GTGGAA 1 -- us2k10--------
    rs1455877871,2
    --27013828(+) GGATAC/GAGTGA 1 -- us2k10--------
    rs1155641211,2
    C,F--27013876(+) GAAAAC/TTCCTT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1488404581,2
    C--27013905(+) TGCTAA/CGTATC 1 -- us2k10--------
    rs1884609071,2
    C--27013956(+) CTCCAG/TGCATG 1 -- us2k10--------
    rs71066761,2
    C,F,A,H--27014032(+) GGTTGT/CTTATA 1 -- us2k123Minor allele frequency- C:0.22NS EA NA WA CSA 2486
    rs1435007361,2
    --27014270(+) AGCCCA/TATTGA 1 -- us2k10--------
    rs1917133671,2
    --27014386(+) ACCTCC/TCTCTC 1 -- us2k10--------
    rs1839298061,2
    --27014553(+) AGTGAC/TCCACC 1 -- us2k10--------
    rs1868644901,2
    --27014561(+) ACCCAA/CCTCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FIBIN (27015628 - 27018634 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FIBIN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897146CNV Loss21882294
    nsv897147CNV Loss21882294

    Human Gene Mutation Database (HGMD): FIBIN
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FIBIN
    DNA2.0 Custom Variant and Variant Library Synthesis for FIBIN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FIBIN           About GenesLikeMe

    Genetic Association Database (GAD): FIBIN
    Human Genome Epidemiology (HuGE) Navigator: FIBIN (1 document)

    Export disorders for FIBIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FIBIN gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FIBIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibin, a novel secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish. (PubMed id 17196583)1, 2, 3 Wakahara T....Itoh N. (Dev. Biol. 2007)
    2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. Characterization of the expression, promoter activity and molecular architecture of fibin. (PubMed id 21615908)2 Lakner J.... Schoneberg T. (BMC Biochem. 2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. (PubMed id 11827452)1 Jia L....Francomano C.A. (Genomics 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 387758 HGNC: 33747 AceView: LOC387758 Ensembl:ENSG00000176971 euGenes: HUgn387758
    ECgene: FIBIN H-InvDB: FIBIN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FIBIN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FIBIN gene:
    Search GeneIP for patents involving FIBIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FIBIN Predesigned siRNA for gene silencing in human, mouse, rat FIBIN
     QuantiFast Probe-based Assays in human, mouse, rat FIBIN QuantiTect SYBR Green Assays in human, mouse, rat FIBIN
     Custom PCR Arrays for FIBIN Search Chromatin IP Primers for FIBIN
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     Search for Antibodies & Assays

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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIBIN
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FIBIN
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FIBIN
     Search LSBio for Antibodies for FIBIN
     Browse compounds at ApexBio
     Search Addgene for plasmids for FIBIN
      Search eBioscience for proteins for FIBIN
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     antibodies-online antibodies for FIBIN (3 products)
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     antibodies-online proteins for FIBIN (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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