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Aliases for FIBIN Gene

Aliases for FIBIN Gene

  • Fin Bud Initiation Factor Homolog (Zebrafish) 2 3

External Ids for FIBIN Gene

Previous GeneCards Identifiers for FIBIN Gene

  • GC11P026713

Summaries for FIBIN Gene

GeneCards Summary for FIBIN Gene

FIBIN (Fin Bud Initiation Factor Homolog (Zebrafish)) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIBIN Gene

Genomics for FIBIN Gene

Regulatory Elements for FIBIN Gene

Genomic Location for FIBIN Gene

26,994,081 bp from pter
26,997,087 bp from pter
3,007 bases
Plus strand

Genomic View for FIBIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FIBIN Gene

Proteins for FIBIN Gene

  • Protein details for FIBIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fin bud initiation factor homolog
    Protein Accession:

    Protein attributes for FIBIN Gene

    211 amino acids
    Molecular mass:
    24273 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Seems to also exist as monomers.

neXtProt entry for FIBIN Gene

Proteomics data for FIBIN Gene at MOPED

Post-translational modifications for FIBIN Gene

  • Glycosylation at Asn 30
  • Modification sites at PhosphoSitePlus

Other Protein References for FIBIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FIBIN Gene

Domains & Families for FIBIN Gene

Protein Domains for FIBIN Gene


Suggested Antigen Peptide Sequences for FIBIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FIBIN family.
  • Belongs to the FIBIN family.
genes like me logo Genes that share domains with FIBIN: view

No data available for Gene Families for FIBIN Gene

Function for FIBIN Gene

Phenotypes for FIBIN Gene

GenomeRNAi human phenotypes for FIBIN:
genes like me logo Genes that share phenotypes with FIBIN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FIBIN

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FIBIN Gene

Localization for FIBIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIBIN Gene

Secreted. Golgi apparatus. Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for FIBIN Gene COMPARTMENTS Subcellular localization image for FIBIN gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 3
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for FIBIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with FIBIN: view

Pathways & Interactions for FIBIN Gene

SuperPathways for FIBIN Gene

No Data Available

Interacting Proteins for FIBIN Gene

Gene Ontology (GO) - Biological Process for FIBIN Gene


No data available for Pathways by source and SIGNOR curated interactions for FIBIN Gene

Drugs & Compounds for FIBIN Gene

No Compound Related Data Available

Transcripts for FIBIN Gene

mRNA/cDNA for FIBIN Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(114) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FIBIN Gene

Fin bud initiation factor homolog (zebrafish):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FIBIN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIBIN Gene

No ASD Table

Relevant External Links for FIBIN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FIBIN Gene

mRNA expression in normal human tissues for FIBIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FIBIN Gene

This gene is overexpressed in Artery - Aorta (x7.7) and Nerve - Tibial (x5.7).

Protein differential expression in normal tissues from HIPED for FIBIN Gene

This gene is overexpressed in Fetal gut (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FIBIN Gene

SOURCE GeneReport for Unigene cluster for FIBIN Gene Hs.712718

genes like me logo Genes that share expression patterns with FIBIN: view

Protein tissue co-expression partners for FIBIN Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FIBIN Gene

Orthologs for FIBIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for FIBIN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FIBIN 35
  • 91.79 (n)
  • 96.21 (a)
  • 96 (a)
(Canis familiaris)
Mammalia FIBIN 35
  • 78.04 (n)
  • 74.88 (a)
  • 75 (a)
(Mus musculus)
Mammalia Fibin 35
  • 89.52 (n)
  • 93.81 (a)
Fibin 16
Fibin 36
  • 91 (a)
(Pan troglodytes)
Mammalia FIBIN 35
  • 99.84 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Fibin 35
  • 88.73 (n)
  • 92.86 (a)
(Gallus gallus)
Aves FIBIN 35
  • 74.06 (n)
  • 73.89 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia FIBIN 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fibin 35
  • 69.62 (n)
  • 67.49 (a)
(Danio rerio)
Actinopterygii sbcb374 35
fibina 36
  • 51 (a)
fibinb 36
  • 61 (a)
Species with no ortholog for FIBIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FIBIN Gene

Gene Tree for FIBIN (if available)
Gene Tree for FIBIN (if available)

Paralogs for FIBIN Gene

No data available for Paralogs for FIBIN Gene

Variants for FIBIN Gene

Sequence variations from dbSNP and Humsavar for FIBIN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7892 -- 26,996,060(+) GAATC(C/G)TAATT utr-variant-3-prime
rs2350934 -- 26,996,472(+) CTACA(A/G)TGATG utr-variant-3-prime
rs7106676 -- 26,992,485(+) GGTTG(C/T)TTATA upstream-variant-2KB
rs7111860 -- 26,994,143(+) TACTA(G/T)CAGGG utr-variant-5-prime
rs7125909 -- 26,993,937(+) AAATT(C/G)TATTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FIBIN Gene

Variant ID Type Subtype PubMed ID
nsv897146 CNV Loss 21882294
nsv897147 CNV Loss 21882294

Variation tolerance for FIBIN Gene

Residual Variation Intolerance Score: 68.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIBIN Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIBIN Gene

Disorders for FIBIN Gene

Relevant External Links for FIBIN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FIBIN: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIBIN Gene

Publications for FIBIN Gene

  1. Fibin, a novel secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish. (PMID: 17196583) Wakahara T. … Itoh N. (Dev. Biol. 2007) 2 67
  2. Characterization of the expression, promoter activity and molecular architecture of fibin. (PMID: 21615908) Lakner J. … Schoneberg T. (BMC Biochem. 2011) 67
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 67
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for FIBIN Gene

Sources for FIBIN Gene

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