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Aliases for FIBCD1 Gene

Aliases for FIBCD1 Gene

  • Fibrinogen C Domain Containing 1 2 3

External Ids for FIBCD1 Gene

Summaries for FIBCD1 Gene

Entrez Gene Summary for FIBCD1 Gene

  • FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010]

GeneCards Summary for FIBCD1 Gene

FIBCD1 (Fibrinogen C Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include chitin binding. An important paralog of this gene is FGB.

UniProtKB/Swiss-Prot for FIBCD1 Gene

  • Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIBCD1 Gene

Genomics for FIBCD1 Gene

Genomic Location for FIBCD1 Gene

Start:
130,902,438 bp from pter
End:
130,939,286 bp from pter
Size:
36,849 bases
Orientation:
Minus strand

Genomic View for FIBCD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FIBCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIBCD1 Gene

Regulatory Elements for FIBCD1 Gene

Proteins for FIBCD1 Gene

  • Protein details for FIBCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N539-FBCD1_HUMAN
    Recommended name:
    Fibrinogen C domain-containing protein 1
    Protein Accession:
    Q8N539
    Secondary Accessions:
    • A3KFK0
    • Q6UXK6
    • Q96SJ7

    Protein attributes for FIBCD1 Gene

    Size:
    461 amino acids
    Molecular mass:
    50744 Da
    Quaternary structure:
    • Homotetramer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for FIBCD1 Gene

    Alternative splice isoforms for FIBCD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FIBCD1 Gene

Proteomics data for FIBCD1 Gene at MOPED

Post-translational modifications for FIBCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn340

Other Protein References for FIBCD1 Gene

No data available for DME Specific Peptides for FIBCD1 Gene

Domains for FIBCD1 Gene

Gene Families for FIBCD1 Gene

HGNC:
  • FIBC :Fibrinogen C domain containing

Suggested Antigen Peptide Sequences for FIBCD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N539

UniProtKB/Swiss-Prot:

FBCD1_HUMAN
Domain:
  • Contains 1 fibrinogen C-terminal domain.:
    • Q8N539
genes like me logo Genes that share domains with FIBCD1: view

Function for FIBCD1 Gene

Molecular function for FIBCD1 Gene

UniProtKB/Swiss-Prot Function: Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.

Gene Ontology (GO) - Molecular Function for FIBCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008061 chitin binding IDA 19710473
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FIBCD1: view

Phenotypes for FIBCD1 Gene

GenomeRNAi human phenotypes for FIBCD1:
genes like me logo Genes that share phenotypes with FIBCD1: view

miRNA for FIBCD1 Gene

miRTarBase miRNAs that target FIBCD1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FIBCD1 Gene

Localization for FIBCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIBCD1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FIBCD1 Gene COMPARTMENTS Subcellular localization image for FIBCD1 gene
Compartment Confidence
plasma membrane 3
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FIBCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19710473
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FIBCD1: view

Pathways for FIBCD1 Gene

SuperPathways for FIBCD1 Gene

No Data Available

Interacting Proteins for FIBCD1 Gene

Gene Ontology (GO) - Biological Process for FIBCD1 Gene

None

No data available for Pathways by source for FIBCD1 Gene

Transcripts for FIBCD1 Gene

Unigene Clusters for FIBCD1 Gene

Fibrinogen C domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FIBCD1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2: - -
SP3: - -
SP4: - -

Relevant External Links for FIBCD1 Gene

GeneLoc Exon Structure for
FIBCD1
ECgene alternative splicing isoforms for
FIBCD1

Expression for FIBCD1 Gene

mRNA expression in normal human tissues for FIBCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FIBCD1 Gene

This gene is overexpressed in Brain - Hippocampus (17.3), Adrenal Gland (8.6), and Testis (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FIBCD1 Gene

SOURCE GeneReport for Unigene cluster for FIBCD1 Gene Hs.133205

mRNA Expression by UniProt/SwissProt for FIBCD1 Gene

Q8N539-FBCD1_HUMAN
Tissue specificity: Expressed in the small and large intestinal epithelial cells with a highly polarized localization to the apical surface corresponding to the brush border and in the ducts of the salivary gland.
genes like me logo Genes that share expressions with FIBCD1: view

Orthologs for FIBCD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FIBCD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIBCD1 35
  • 99.28 (n)
  • 99.57 (a)
FIBCD1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FIBCD1 35
  • 89.28 (n)
  • 92.11 (a)
FIBCD1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FIBCD1 35
  • 89.01 (n)
  • 90.24 (a)
FIBCD1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fibcd1 35
  • 85.98 (n)
  • 90.63 (a)
Fibcd1 16
Fibcd1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FIBCD1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FIBCD1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fibcd1 35
  • 85.62 (n)
  • 91.07 (a)
chicken
(Gallus gallus)
Aves FIBCD1 35
  • 75.6 (n)
  • 73.42 (a)
FIBCD1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 85 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.6455 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fibcd1 35
  • 70.1 (n)
  • 67.76 (a)
zebrafish
(Danio rerio)
Actinopterygii fibcd1 36
  • 66 (a)
OneToMany
FIBCD1 (2 of 2) 36
  • 81 (a)
OneToMany
si:dkeyp-51b7.3 35
  • 69.21 (n)
  • 67.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30280 35
  • 55.83 (n)
  • 47.57 (a)
CG41520 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
Species with no ortholog for FIBCD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FIBCD1 Gene

ENSEMBL:
Gene Tree for FIBCD1 (if available)
TreeFam:
Gene Tree for FIBCD1 (if available)

Paralogs for FIBCD1 Gene

Pseudogenes.org Pseudogenes for FIBCD1 Gene

genes like me logo Genes that share paralogs with FIBCD1: view

Variants for FIBCD1 Gene

Sequence variations from dbSNP and Humsavar for FIBCD1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs913720 -- 130,923,181(+) ACCTT(C/G)TGTGG intron-variant
rs1881104 -- 130,921,986(-) CAGGC(A/G)GCCGG intron-variant
rs1966219 -- 130,914,985(-) CGGCC(A/G)CCTGG intron-variant
rs2049667 -- 130,933,297(-) CAGTT(A/G)GGCTG intron-variant
rs2049668 -- 130,910,240(+) gcccc(C/G)gggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FIBCD1 Gene

Variant ID Type Subtype PubMed ID
dgv2423e1 CNV Complex 17122850
nsv6735 CNV Loss 18451855
nsv893960 CNV Gain 21882294
dgv8306n71 CNV Loss 21882294
dgv8307n71 CNV Loss 21882294
nsv893963 CNV Loss 21882294
nsv469903 CNV Loss 18288195
nsv893966 CNV Gain 21882294
nsv466601 CNV Loss 19166990
nsv831737 CNV Loss 17160897
dgv8308n71 CNV Loss 21882294
nsv522953 CNV Loss 19592680
nsv526527 CNV Loss 19592680
nsv825125 CNV Gain 20364138
esv2677011 CNV Deletion 23128226
nsv8572 CNV Gain 18304495

Relevant External Links for FIBCD1 Gene

HapMap Linkage Disequilibrium report
FIBCD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIBCD1 Gene

Disorders for FIBCD1 Gene

Relevant External Links for FIBCD1

Human Genome Epidemiology (HuGE) Navigator
FIBCD1
genes like me logo Genes that share disorders with FIBCD1: view

No data available for UniProtKB/Swiss-Prot for FIBCD1 Gene

Publications for FIBCD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin. (PMID: 19710473) Schlosser A. … Holmskov U. (J. Immunol. 2009) 3 4
  4. The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. (PMID: 19892701) Thomsen T. … Holmskov U. (J. Biol. Chem. 2010) 3 4
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for FIBCD1 Gene

Sources for FIBCD1 Gene

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