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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FHOD3 Gene

protein-coding   GIFtS: 52
GCID: GC18P033877

Formin Homology 2 Domain Containing 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Formin Homology 2 Domain Containing 31 2     Formactin22
FHOS22 3 5     FH1/FH2 Domain-Containing Protein 32
Formin Homolog Overexpressed In Spleen 22 3     formactin-22
hFHOS22 3     Formactin-23
KIAA16953 5     

External Ids:    HGNC: 261781   Entrez Gene: 802062   Ensembl: ENSG000001347757   OMIM: 6096915   UniProtKB: Q2V2M93   

Export aliases for FHOD3 gene to outside databases

Previous GC identifers: GC18P032344 GC18P032129 GC18P032131 GC18P030735


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FHOD3 Gene:
Proteins that contain formin (FMN1; MIM 136535) homology (FH) domains, such as FHOD3, play a role in regulation of
the actin cytoskeleton (Kanaya et al., 2005 (PubMed 15966898)).(supplied by OMIM, Apr 2010)

GeneCards Summary for FHOD3 Gene: 
FHOD3 (formin homology 2 domain containing 3) is a protein-coding gene. Diseases associated with FHOD3 include ischemic heart disease, and dilated cardiomyopathy. GO annotations related to this gene include protein binding and actin binding. An important paralog of this gene is FHOD1.

UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9
Function: Actin-organizing protein that may cause stress fiber formation together with cell elongation (By
similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010966.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FHOD3 gene promoter:
         NF-1   p53   ATF-2   MyoD   Nkx2-5   Nkx5-1   PPAR-gamma1   POU2F1a   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFHOD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FHOD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FHOD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12   Ensembl cytogenetic band:  18q12.2   HGNC cytogenetic band: 18q12

FHOD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FHOD3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P033877:  view genomic region     (about GC identifiers)

Start:
33,877,677 bp from pter      End:
34,360,018 bp from pter
Size:
482,342 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9 (See protein sequence)
Recommended Name: FH1/FH2 domain-containing protein 3  
Size: 1422 amino acids; 158613 Da
Subunit: Interacts with nestin/NES-based interfilament (IF) (By similarity). Interacts with SQSTM1; isoform 4
threonine phosphorylation disrupts SQSTM1-binding
Subcellular location: Cytoplasm, cytoskeleton. Note=Main part of the protein localizes to actin fibers and the
remaining part displays filamentous staining (By similarity)
Subcellular location: Isoform 4: Cytoplasm, myofibril, sarcomere, Z line. Note=Threonine phosphorylation in
isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes
Sequence caution: Sequence=BAB15292.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15463.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MQT4 E5F5Q0 Q642I2 Q6ZRQ7 Q86TF9 Q8N3A5 Q9C0G8 Q9H604 Q9H6G7
Alternative splicing: 4 isoforms:  Q2V2M9-1   Q2V2M9-2   Q2V2M9-3   Q2V2M9-4   (Phosphorylated at Thr-1474 and Thr-1476 by CK2)

Explore the universe of human proteins at neXtProt for FHOD3: NX_Q2V2M9

Explore proteomics data for FHOD3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q2V2M9

  • FHOD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FHOD3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001268668.1  NP_001268669.1  NP_079411.2  

    ENSEMBL proteins: 
     ENSP00000257209   ENSP00000466937   ENSP00000352186   ENSP00000467195   ENSP00000468163  
     ENSP00000467462   ENSP00000465843   ENSP00000411430  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FHOD3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IEA--
    GO:0030018Z disc IEA--

    FHOD3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR015425 FH2_actin-bd
     IPR014767 Diaphanous_autoregulatory
     IPR003104 Actin-bd_FH2/DRF_autoreg
     IPR014768 GTPase-bd/formin_homology_3
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q2V2M9

    ProtoNet protein and cluster: Q2V2M9

    1 Blocks protein domain: IPB003104 Actin-binding FH2

    UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9
    Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This
    autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2
    domain to then nucleate and elongate nonbranched actin filaments (By similarity)
    Similarity: Belongs to the formin homology family
    Similarity: Contains 1 DAD (diaphanous autoregulatory) domain
    Similarity: Contains 1 FH1 (formin homology 1) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain
    Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


    FHOD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FHOD3_HUMAN, Q2V2M9
    Function: Actin-organizing protein that may cause stress fiber formation together with cell elongation (By
    similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI--
         
    FHOD3 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fhod3):
     cardiovascular system  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     muscle 

    FHOD3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FHOD3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FHOD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FHOD3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FHOD3 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidFHOD3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHOD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FHOD3

    1 Interacting protein for FHOD3 (Q2V2M91) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135011EBI-6395541,EBI-307104
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007015actin filament organization IEA--
    GO:0030036actin cytoskeleton organization ----
    GO:0030837negative regulation of actin filament polymerization IEA--
    GO:0045214sarcomere organization IEA--

    FHOD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FHOD3

    Search CenterWatch for drugs/clinical trials and news about FHOD3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FHOD3 gene (3 alternative transcripts): 
    NM_001281739.1  NM_001281740.1  NM_025135.3  

    Unigene Cluster for FHOD3:

    Formin homology 2 domain containing 3
    Hs.630884  [show with all ESTs]
    Unigene Representative Sequence: NM_025135
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257209(uc002kzs.1 uc021uiv.1) ENST00000589114 ENST00000590592
    ENST00000359247(uc002kzr.1 uc002kzt.1 uc002kzu.1) ENST00000591635
    ENST00000592930 ENST00000587493 ENST00000592128 ENST00000585579 ENST00000445677(uc010dmz.1 uc010dna.1 uc010dnb.1)

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate FHOD3 (see all 12):
    hsa-miR-30c hsa-miR-618 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-30a hsa-miR-493* hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidFHOD3 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FHOD3

    Additional mRNA sequence: 

    AB051482.1 AB084087.1 AK025950.1 AK026370.1 AK091899.1 AK128053.1 AK308859.1 AL834480.1 
    BC031518.1 BC041040.1 BC050670.1 BC058897.1 BC081563.1 BC131751.1 HM191478.1 

    10 DOTS entries:

    DT.214877  DT.97799371  DT.100779061  DT.95182809  DT.75195798  DT.95372571  DT.100713617  DT.100018234 
    DT.121104257  DT.91807843 

    24/109 AceView cDNA sequences (see all 109):

    T33312 AA628057 AK025950 AL834480 BU740907 BU739165 BQ721062 AB051482 
    BQ018555 AA338649 AI250754 AK026370 AI686400 AA744547 BM717357 BM977660 
    BC050670 BM727065 AK128053 Z42955 AA766002 AI420245 AI131287 BC081563 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FHOD3 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                -                 -     -     -     -     -     -                                                                           
    SP2:                                                                                                                                            -               
    SP3:                                                                                                                                                            
    SP4:                                                              -     -     -     -     -                                                                     
    SP5:                                                              -                                                                                             


    ECgene alternative splicing isoforms for FHOD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FHOD3 expression in normal human tissues (normalized intensities)      FHOD3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAAATAC
    FHOD3 Expression
    About this image


    FHOD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Postnatal Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Intervertebral Disc Annulus Fibrosus Cells Thoracic Intervertebral Disc
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Smooth Muscle (Extraembryonic Tissues)
             Human umbilical Smooth Muscle (HUSM)   

    See FHOD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FHOD3

    SOURCE GeneReport for Unigene cluster: Hs.630884

    UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9
    Tissue specificity: Expressed in the heart, kidney and brain. May be down-regulated in various types of heart
    diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated
    cardiomyopathies, as well as ischemic heart disease (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHOD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FHOD3 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fhod35 formin homology 2 domain containing 3   --   18 (13.18 cM) 24709445 
    chicken
    (Gallus gallus)
    Aves FHOD31 formin homology 2 domain containing 3 77.45(n)
    81.12(a)
      420952  XM_419037.3  XP_419037.3 
    lizard
    (Anolis carolinensis)
    Reptilia FHOD36
    formin homology 2 domain containing 3
    65(a)
    1 ↔ 1
    6(57752584-57893023)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX683094.12   -- 76.62(n)    BX683094.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1037461 zgc:103746 67.01(n)
    69.51(a)
      570795  XM_694317.4  XP_699409.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fhos1 CG42610-PA 54.09(n)
    51.45(a)
      39004  NM_001169916.1  NP_001163387.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fhod-16
    Protein FHOD-1
    33(a)
    possible ortholog
    I(5058251-5068829)


    ENSEMBL Gene Tree for FHOD3 (if available)
    TreeFam Gene Tree for FHOD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FHOD3 gene
    FHOD12  
    1 SIMAP similar gene for FHOD3 using alignment to 5 protein entries:     FHOD3_HUMAN (see all proteins):
    FHOD1

    FHOD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9571 SNPs in FHOD3 are shown (see all 9571)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146713551,2
    C,F--30733801(+) CTCCAG/AGTAAG 1 -- int11Minor allele frequency- A:0.12WA 118
    rs1172721901,2
    F--30733865(+) GATGTC/TATGGG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1921920701,2
    --30733899(+) TGCTAA/GGAAAT 1 -- int10--------
    rs1819716761,2
    --30734034(+) CATTAC/GGATTG 1 -- int10--------
    rs6713951,2
    C,F--30734038(-) TACTCC/AATCCT 1 -- int19Minor allele frequency- A:0.31NA WA CSA EA 370
    rs776333961,2
    C,F--30734079(+) AATGCC/TGGGAC 1 -- int11Minor allele frequency- T:0.02NA 120
    rs753146961,2
    C,F--30734095(+) AAAAAA/GGTATT 1 -- int11Minor allele frequency- G:0.12WA 118
    rs1449263061,2
    --30734156(+) TTAAAA/GTGCAG 1 -- int10--------
    rs112734001,2
    C--31130458(+) TTTTG-/TTG   
      CCTCTC
    TTACC
    1 -- int10--------
    rs1152479741,2
    F--33875801(+) GGAGGC/TCCCTG 1 -- us2k11Minor allele frequency- T:0.07WA 118

    HapMap Linkage Disequilibrium report for FHOD3 (33877677 - 34127677 bp, first 250kb of FHOD3)

    Structural Variations
         Database of Genomic Variants (DGV) 10/40 variations for FHOD3 (see all 40):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664060CNV Deletion23128226
    esv2656572CNV Deletion23128226
    esv2716960CNV Deletion23290073
    esv2656975CNV Deletion23128226
    esv2716961CNV Deletion23290073
    nsv436238CNV Deletion17901297
    esv2672452CNV Deletion23128226
    esv2658053CNV Deletion23128226
    nsv2256CNV Insertion18451855
    nsv513492CNV Insertion21212237


    Human Gene Mutation Database (HGMD): FHOD3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FHOD3
    DNA2.0 Custom Variant and Variant Library Synthesis for FHOD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609691    OMIM disorders: --

    3 diseases for FHOD3:    About MalaCards
    ischemic heart disease    dilated cardiomyopathy    leukemia


    FHOD3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FHOD3
    Human Genome Epidemiology (HuGE) Navigator: FHOD3 (2 documents)

    Export disorders for FHOD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FHOD3 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with FHOD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. (PubMed id 21149568)1, 2 Iskratsch T.... Ehler E. (2010)
    4. Genomewide pharmacogenomic study of metabolic side ef fects to antipsychotic drugs. (PubMed id 20195266)1, 4 Adkins D.E....van den Oord E.J. (2010)
    5. Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament. (PubMed id 15966898)1, 2 Kanaya H.... Sumimoto H. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Identification and characterization of human FHOD3 gene in silico. (PubMed id 15010865)1, 9 Katoh M. and Katoh M. (2004)
    8. Formin homology 2 domain containing 3 variants associa ted with hypertrophic cardiomyopathy. (PubMed id 23255317)1 Wooten E.C....Huggins G.S. (2013)
    9. Two distinct phosphorylation events govern the functio n of muscle FHOD3. (PubMed id 23052206)1 Iskratsch T....Ehler E. (2013)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80206 HGNC: 26178 AceView: FHOD3 Ensembl:ENSG00000134775 euGenes: HUgn80206
    ECgene: FHOD3 H-InvDB: FHOD3

    (According to HUGE)
    About This Section
    HUGE: KIAA1695

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FHOD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FHOD3 gene:
    Search GeneIP for patents involving FHOD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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