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Aliases for FHOD3 Gene

Aliases for FHOD3 Gene

  • Formin Homology 2 Domain Containing 3 2 3
  • FHOS2 3 4 6
  • Formin Homolog Overexpressed In Spleen 2 3 4
  • Formactin-2 3 4
  • KIAA1695 4 6
  • HFHOS2 3 4
  • FH1/FH2 Domain-Containing Protein 3 3
  • Formactin2 3

External Ids for FHOD3 Gene

Previous GeneCards Identifiers for FHOD3 Gene

  • GC18P032344
  • GC18P032129
  • GC18P032131
  • GC18P033877
  • GC18P030735

Summaries for FHOD3 Gene

Entrez Gene Summary for FHOD3 Gene

  • Proteins that contain formin (FMN1; MIM 136535) homology (FH) domains, such as FHOD3, play a role in regulation of the actin cytoskeleton (Kanaya et al., 2005 [PubMed 15966898]).[supplied by OMIM, Apr 2010]

GeneCards Summary for FHOD3 Gene

FHOD3 (Formin Homology 2 Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is FHOD1.

UniProtKB/Swiss-Prot for FHOD3 Gene

  • Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHOD3 Gene

Genomics for FHOD3 Gene

Regulatory Elements for FHOD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FHOD3 Gene

36,297,696 bp from pter
36,780,059 bp from pter
482,364 bases
Plus strand

Genomic View for FHOD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FHOD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHOD3 Gene

Proteins for FHOD3 Gene

  • Protein details for FHOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FH1/FH2 domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A8MQT4
    • E5F5Q0
    • Q642I2
    • Q6ZRQ7
    • Q86TF9
    • Q8N3A5
    • Q9C0G8
    • Q9H604
    • Q9H6G7

    Protein attributes for FHOD3 Gene

    1422 amino acids
    Molecular mass:
    158613 Da
    Quaternary structure:
    • Interacts with nestin/NES-based interfilament (IF) (By similarity). Interacts with SQSTM1; isoform 4 threonine phosphorylation disrupts SQSTM1-binding.
    • Sequence=BAB15292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15463.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FHOD3 Gene


neXtProt entry for FHOD3 Gene

Proteomics data for FHOD3 Gene at MOPED

Post-translational modifications for FHOD3 Gene

No data available for DME Specific Peptides for FHOD3 Gene

Domains for FHOD3 Gene

Suggested Antigen Peptide Sequences for FHOD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q2V2M9
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Contains 1 DAD (diaphanous autoregulatory) domain.
  • Contains 1 FH1 (formin homology 1) domain.
  • Contains 1 FH2 (formin homology 2) domain.
  • Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with FHOD3: view

No data available for Gene Families for FHOD3 Gene

Function for FHOD3 Gene

Molecular function for FHOD3 Gene

UniProtKB/Swiss-Prot Function: Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes.

Gene Ontology (GO) - Molecular Function for FHOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 21149568
genes like me logo Genes that share ontologies with FHOD3: view
genes like me logo Genes that share phenotypes with FHOD3: view

Animal Model Products

CRISPR Products

miRNA for FHOD3 Gene

miRTarBase miRNAs that target FHOD3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FHOD3 Gene

Localization for FHOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FHOD3 Gene

Cytoplasm, cytoskeleton. Note=Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining. {ECO:0000250}.
Isoform 4: Cytoplasm, myofibril, sarcomere, Z line. Note=Threonine phosphorylation in isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes.

Subcellular locations from

Jensen Localization Image for FHOD3 Gene COMPARTMENTS Subcellular localization image for FHOD3 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for FHOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005865 striated muscle thin filament IEA --
GO:0030017 sarcomere --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with FHOD3: view

Pathways for FHOD3 Gene

SuperPathways for FHOD3 Gene

No Data Available

Interacting Proteins for FHOD3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000257209 Q2V2M9-FHOD3_HUMAN for FHOD3 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for FHOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization --
GO:0030837 negative regulation of actin filament polymerization IEA --
GO:0045214 sarcomere organization IEA --
GO:0051639 actin filament network formation IEA --
GO:0055003 cardiac myofibril assembly IEA --
genes like me logo Genes that share ontologies with FHOD3: view

No data available for Pathways by source for FHOD3 Gene

Transcripts for FHOD3 Gene

Unigene Clusters for FHOD3 Gene

Formin homology 2 domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FHOD3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FHOD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - - - -
SP2: -
SP4: - - - - -
SP5: -

Relevant External Links for FHOD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FHOD3 Gene

mRNA expression in normal human tissues for FHOD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FHOD3 Gene

This gene is overexpressed in Heart - Left Ventricle (13.6) and Heart - Atrial Appendage (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FHOD3 Gene

SOURCE GeneReport for Unigene cluster for FHOD3 Gene Hs.630884

mRNA Expression by UniProt/SwissProt for FHOD3 Gene

Tissue specificity: Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as ischemic heart disease (at protein level).
genes like me logo Genes that share expressions with FHOD3: view

In Situ Assay Products

Orthologs for FHOD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FHOD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FHOD3 35
  • 99.37 (n)
  • 99.24 (a)
FHOD3 36
  • 100 (a)
(Bos Taurus)
Mammalia FHOD3 35
  • 89.49 (n)
  • 93.18 (a)
FHOD3 36
  • 93 (a)
(Canis familiaris)
Mammalia FHOD3 35
  • 87.63 (n)
  • 90.06 (a)
FHOD3 36
  • 80 (a)
(Mus musculus)
Mammalia Fhod3 35
  • 85.45 (n)
  • 88.8 (a)
Fhod3 16
Fhod3 36
  • 81 (a)
(Monodelphis domestica)
Mammalia FHOD3 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia FHOD3 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Fhod3 35
  • 85.29 (n)
  • 88.43 (a)
(Gallus gallus)
Aves FHOD3 35
  • 75.09 (n)
  • 77.83 (a)
FHOD3 36
  • 69 (a)
(Anolis carolinensis)
Reptilia FHOD3 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fhod3 35
  • 67.42 (n)
  • 69.96 (a)
(Danio rerio)
Actinopterygii FHOD3 (1 of 2) 36
  • 63 (a)
FHOD3 (2 of 2) 36
  • 64 (a)
zgc:103746 35
  • 71.25 (n)
  • 78.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fhos 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea fhod-1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2479 36
  • 49 (a)
Species with no ortholog for FHOD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FHOD3 Gene

Gene Tree for FHOD3 (if available)
Gene Tree for FHOD3 (if available)

Paralogs for FHOD3 Gene

Paralogs for FHOD3 Gene

Selected SIMAP similar genes for FHOD3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FHOD3: view

Variants for FHOD3 Gene

Sequence variations from dbSNP and Humsavar for FHOD3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs471410 -- 36,526,232(+) GACAC(A/C)AAAAC intron-variant
rs471713 -- 36,689,383(+) CAGCA(A/G)ATGGT intron-variant
rs479570 -- 36,693,076(+) CTGAC(C/T)CTCCA intron-variant
rs480006 -- 36,548,191(+) tgtct(A/C)aaaaa intron-variant
rs480906 -- 36,325,350(+) GAAGC(A/G)ATTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FHOD3 Gene

Variant ID Type Subtype PubMed ID
nsv522170 CNV Loss 19592680
esv2716960 CNV Deletion 23290073
esv2658053 CNV Deletion 23128226
nsv527769 CNV Loss 19592680
esv2656572 CNV Deletion 23128226
nsv828211 CNV Loss 20364138
dgv1023e1 CNV Complex 17122850
esv2664060 CNV Deletion 23128226
nsv833620 CNV Gain 17160897
nsv819365 CNV Loss 19587683
nsv909540 CNV Gain 21882294
esv2672452 CNV Deletion 23128226
nsv525007 CNV Loss 19592680
esv996876 CNV Insertion 20482838
nsv9625 CNV Loss 18304495
nsv513492 CNV Insertion 21212237
esv1752551 CNV Insertion 17803354
esv1093578 CNV Insertion 17803354
dgv1024e1 CNV Complex 17122850
esv21615 CNV Loss 19812545
nsv518778 CNV Loss 19592680
esv2656975 CNV Deletion 23128226
nsv909541 CNV Gain 21882294
nsv130624 CNV Loss 16902084
esv34228 CNV Gain 17911159
nsv817789 CNV Gain 17921354
nsv438280 CNV Loss 16468122
nsv2256 CNV Insertion 18451855
nsv9626 CNV Loss 18304495
nsv909542 CNV Gain 21882294
nsv909543 CNV Loss 21882294
esv2716961 CNV Deletion 23290073
nsv526596 CNV Gain 19592680
nsv909544 CNV Gain 21882294
nsv437823 CNV Loss 16327808
nsv436238 CNV Deletion 17901297
esv24629 CNV Loss 19812545
nsv442433 CNV CNV 18776908
nsv438282 CNV Loss 16468122
nsv132037 CNV Loss 16902084

Relevant External Links for FHOD3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHOD3 Gene

Disorders for FHOD3 Gene

Relevant External Links for FHOD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FHOD3: view

No data available for UniProtKB/Swiss-Prot for FHOD3 Gene

Publications for FHOD3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Identification and characterization of human FHOD3 gene in silico. (PMID: 15010865) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament. (PMID: 15966898) Kanaya H. … Sumimoto H. (Genes Cells 2005) 3 4
  5. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PMID: 20195266) Adkins D.E. … van den Oord E.J. (Mol. Psychiatry 2011) 3 48

Products for FHOD3 Gene

Sources for FHOD3 Gene

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