Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FHOD3 Gene

protein-coding   GIFtS: 52
GCID: GC18P033877

Formin Homology 2 Domain Containing 3

  Search for FHOD3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Formin Homology 2 Domain Containing 31 2     Formactin22
FHOS22 3 5     FH1/FH2 Domain-Containing Protein 32
Formin Homolog Overexpressed In Spleen 22 3     formactin-22
hFHOS22 3     Formactin-23
KIAA16953 5     

External Ids:    HGNC: 261781   Entrez Gene: 802062   Ensembl: ENSG000001347757   OMIM: 6096915   UniProtKB: Q2V2M93   

Export aliases for FHOD3 gene to outside databases

Previous GC identifers: GC18P032344 GC18P032129 GC18P032131 GC18P030735


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FHOD3 Gene:
Proteins that contain formin (FMN1; MIM 136535) homology (FH) domains, such as FHOD3, play a role in regulation of
the actin cytoskeleton (Kanaya et al., 2005 (PubMed 15966898)).(supplied by OMIM, Apr 2010)

GeneCards Summary for FHOD3 Gene:
FHOD3 (formin homology 2 domain containing 3) is a protein-coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is FHOD1.

UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9
Function: Actin-organizing protein that may cause stress fiber formation together with cell elongation (By
similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FHOD3 gene promoter:
         NF-1   p53   ATF-2   MyoD   Nkx2-5   Nkx5-1   PPAR-gamma1   POU2F1a   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFHOD3 promoter sequence
   Search Chromatin IP Primers for FHOD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FHOD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12   Ensembl cytogenetic band:  18q12.2   HGNC cytogenetic band: 18q12

FHOD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FHOD3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P033877:  view genomic region     (about GC identifiers)

Start:
33,877,677 bp from pter      End:
34,360,018 bp from pter
Size:
482,342 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9 (See protein sequence)
Recommended Name: FH1/FH2 domain-containing protein 3  
Size: 1422 amino acids; 158613 Da
Subunit: Interacts with nestin/NES-based interfilament (IF) (By similarity). Interacts with SQSTM1; isoform 4
threonine phosphorylation disrupts SQSTM1-binding
Sequence caution: Sequence=BAB15292.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15463.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MQT4 E5F5Q0 Q642I2 Q6ZRQ7 Q86TF9 Q8N3A5 Q9C0G8 Q9H604 Q9H6G7
Alternative splicing: 4 isoforms:  Q2V2M9-1   Q2V2M9-2   Q2V2M9-3   Q2V2M9-4   (Contains a phosphothreonine at position 1474. Contains a phosphothreonine at position 1476)

Explore the universe of human proteins at neXtProt for FHOD3: NX_Q2V2M9

Explore proteomics data for FHOD3 at MOPED

Post-translational modifications: 

  • Isoform 4: Phosphorylated on Thr-1474 and Thr-1476 by CK21
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FHOD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001268668.1  NP_001268669.1  NP_079411.2  

    ENSEMBL proteins: 
     ENSP00000257209   ENSP00000466937   ENSP00000352186   ENSP00000467195   ENSP00000468163  
     ENSP00000467462   ENSP00000465843   ENSP00000411430  

    FHOD3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FHOD3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FHOD3
    GenScript Custom Purified and Recombinant Proteins Services for FHOD3
    Novus Biologicals FHOD3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FHOD3

     
    Search eBioscience for Proteins for FHOD3 

    FHOD3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FHOD3
    Novus Biologicals FHOD3 Antibodies
    Abcam antibodies for FHOD3
    Cloud-Clone Corp. Antibodies for FHOD3
    ThermoFisher Antibodies for FHOD3
    LSBio Antibodies in human, mouse, rat for FHOD3

    FHOD3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FHOD3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FHOD3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FHOD3
    Cloud-Clone Corp. CLIAs for FHOD3
    Search eBioscience for ELISAs for FHOD3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR015425 FH2_Formin
     IPR014767 Diaphanous_autoregulatory
     IPR014768 GTPase-bd/formin_homology_3
     IPR016024 ARM-type_fold
     IPR027651 FHOD1/FHOD3

    Graphical View of Domain Structure for InterPro Entry Q2V2M9

    ProtoNet protein and cluster: Q2V2M9

    1 Blocks protein domain: IPB003104 Actin-binding FH2

    UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9
    Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This
    autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2
    domain to then nucleate and elongate nonbranched actin filaments (By similarity)
    Similarity: Belongs to the formin homology family
    Similarity: Contains 1 DAD (diaphanous autoregulatory) domain
    Similarity: Contains 1 FH1 (formin homology 1) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain
    Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


    Find genes that share domains with FHOD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FHOD3_HUMAN, Q2V2M9
    Function: Actin-organizing protein that may cause stress fiber formation together with cell elongation (By
    similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with FHOD3           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fhod3):
     cardiovascular system  embryogenesis  growth/size/body  homeostasis/metabolism  mortality/aging 
     muscle 

    Find genes that share phenotypes with FHOD3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FHOD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FHOD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FHOD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FHOD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target FHOD3:
    hsa-mir-1303 (MIRT035872)

    Block miRNA regulation of human, mouse, rat FHOD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FHOD3 (see all 12):
    hsa-miR-30c hsa-miR-618 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-30a hsa-miR-493* hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidFHOD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FHOD3
    Predesigned siRNA for gene silencing in human, mouse, rat FHOD3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FHOD3

    Clone
    Products:
         
    OriGene clones in human, mouse for FHOD3 (see all 7)
    OriGene ORF clones in mouse, rat for FHOD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FHOD3 (NM_025135)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FHOD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FHOD3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FHOD3
    Browse ESI BIO Cell Lines and PureStem Progenitors for FHOD3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHOD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FHOD3_HUMAN, Q2V2M9: Cytoplasm, cytoskeleton. Note=Main part of the protein localizes to actin fibers and the
    remaining part displays filamentous staining (By similarity)
    FHOD3_HUMAN, Q2V2M9: Isoform 4: Cytoplasm, myofibril, sarcomere, Z line. Note=Threonine phosphorylation in
    isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----
    GO:0005856cytoskeleton ----
    GO:0005865striated muscle thin filament IEA--

    Find genes that share ontologies with FHOD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FHOD3
    Interactions:

        Search GeneGlobe Interaction Network for FHOD3

    1 Interacting protein for FHOD3 (Q2V2M91) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135011EBI-6395541,EBI-307104
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007015actin filament organization ----
    GO:0030837negative regulation of actin filament polymerization IEA--
    GO:0045214sarcomere organization IEA--
    GO:0051639actin filament network formation IEA--

    Find genes that share ontologies with FHOD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FHOD3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FHOD3 gene (3 alternative transcripts): 
    NM_001281739.1  NM_001281740.1  NM_025135.3  

    Unigene Cluster for FHOD3:

    Formin homology 2 domain containing 3
    Hs.630884  [show with all ESTs]
    Unigene Representative Sequence: NM_025135
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257209(uc002kzs.1 uc021uiv.1) ENST00000589114 ENST00000590592
    ENST00000359247(uc002kzr.1 uc002kzt.1 uc002kzu.1) ENST00000591635
    ENST00000592930 ENST00000587493 ENST00000592128 ENST00000585579 ENST00000445677(uc010dmz.1 uc010dna.1 uc010dnb.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FHOD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FHOD3 (see all 12):
    hsa-miR-30c hsa-miR-618 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-30a hsa-miR-493* hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidFHOD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FHOD3
    Predesigned siRNA for gene silencing in human, mouse, rat FHOD3
    Clone
    Products:
         
    OriGene clones in human, mouse for FHOD3 (see all 7)
    OriGene ORF clones in mouse, rat for FHOD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FHOD3 (NM_025135)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FHOD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FHOD3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FHOD3
    OriGene qSTAR qPCR primer pairs in human, mouse for FHOD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FHOD3
      QuantiTect SYBR Green Assays in human, mouse, rat FHOD3
      QuantiFast Probe-based Assays in human, mouse, rat FHOD3

    Additional mRNA sequence: 

    AB051482.1 AB084087.1 AK025950.1 AK026370.1 AK091899.1 AK128053.1 AK308859.1 AL834480.1 
    BC031518.1 BC041040.1 BC050670.1 BC058897.1 BC081563.1 BC131751.1 HM191478.1 

    10 DOTS entries:

    DT.214877  DT.97799371  DT.100779061  DT.95182809  DT.75195798  DT.95372571  DT.100713617  DT.100018234 
    DT.121104257  DT.91807843 

    Selected AceView cDNA sequences (see all 109):

    T33312 AA628057 AK025950 AL834480 BU740907 BU739165 BQ721062 AB051482 
    BQ018555 AA338649 AI250754 AK026370 AI686400 AA744547 BM717357 BM977660 
    BC050670 BM727065 AK128053 Z42955 AA766002 AI420245 AI131287 BC081563 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FHOD3 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                -                 -     -     -     -     -     -                                                                           
    SP2:                                                                                                                                            -               
    SP3:                                                                                                                                                            
    SP4:                                                              -     -     -     -     -                                                                     
    SP5:                                                              -                                                                                             


    ECgene alternative splicing isoforms for FHOD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FHOD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAAATAC
    FHOD3 Expression
    About this image


    FHOD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Mature Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)
             Ureteric Bud Tip Cells Ureteric Bud
     
     Cartilage (Muscoskeletal System)
             Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
    FHOD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FHOD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.630884

    UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9
    Tissue specificity: Expressed in the heart, kidney and brain. May be down-regulated in various types of heart
    diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated
    cardiomyopathies, as well as ischemic heart disease (at protein level)

        Custom PCR Arrays for FHOD3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FHOD3
    OriGene qSTAR qPCR primer pairs in human, mouse for FHOD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FHOD3
    QuantiTect SYBR Green Assays in human, mouse, rat FHOD3
    QuantiFast Probe-based Assays in human, mouse, rat FHOD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHOD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FHOD3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fhod31 , 5 formin homology 2 domain containing 31, 5 85.45(n)1
    88.8(a)1
      18 (13.18 cM)5
    2252881  NM_175276.31  NP_780485.21 
     247094455 
    chicken
    (Gallus gallus)
    Aves FHOD31 formin homology 2 domain containing 3 75.09(n)
    77.83(a)
      420952  XM_419037.4  XP_419037.4 
    lizard
    (Anolis carolinensis)
    Reptilia FHOD36
    formin homology 2 domain containing 3
    65(a)
    1 ↔ 1
    6(57752584-57893023)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX683094.12   -- 76.62(n)    BX683094.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1037461 zgc:103746 71.25(n)
    78.75(a)
      570795  XM_005157949.1  XP_005158006.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fhos6
    --
    18(a)
    1 → many
    3L(8746719-8791819)
    worm
    (Caenorhabditis elegans)
    Secernentea fhod-16
    Protein FHOD-1 (fhod-1) mRNA, complete cds
    28(a)
    1 → many
    I(5058251-5068829) WBGene00016735


    ENSEMBL Gene Tree for FHOD3 (if available)
    TreeFam Gene Tree for FHOD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FHOD3 gene
    FHOD12  
    1 SIMAP similar gene for FHOD3 using alignment to 4 protein entries:     FHOD3_HUMAN (see all proteins):
    FHOD1

    Find genes that share paralogs with FHOD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FHOD3 (see all 9571)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146713551,2
    C,F--30733801(+) CTCCAG/AGTAAG 1 -- int11Minor allele frequency- A:0.12WA 118
    rs1172721901,2
    F--30733865(+) GATGTC/TATGGG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1921920701,2
    --30733899(+) TGCTAA/GGAAAT 1 -- int10--------
    rs1819716761,2
    --30734034(+) CATTAC/GGATTG 1 -- int10--------
    rs6713951,2
    C,F--30734038(-) TACTCC/AATCCT 1 -- int19Minor allele frequency- A:0.31NA WA CSA EA 370
    rs776333961,2
    C,F--30734079(+) AATGCC/TGGGAC 1 -- int11Minor allele frequency- T:0.02NA 120
    rs753146961,2
    C,F--30734095(+) AAAAAA/GGTATT 1 -- int11Minor allele frequency- G:0.12WA 118
    rs1449263061,2
    --30734156(+) TTAAAA/GTGCAG 1 -- int10--------
    rs112734001,2
    C--31130458(+) TTTTG-/TTG   
      CCTCTC
    TTACC
    1 -- int10--------
    rs1152479741,2
    F--33875801(+) GGAGGC/TCCCTG 1 -- us2k11Minor allele frequency- T:0.07WA 118

    HapMap Linkage Disequilibrium report for FHOD3 (33877677 - 34127677 bp, first 250kb of FHOD3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FHOD3 (see all 40):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664060CNV Deletion23128226
    esv2656572CNV Deletion23128226
    esv2716960CNV Deletion23290073
    esv2656975CNV Deletion23128226
    esv2716961CNV Deletion23290073
    nsv436238CNV Deletion17901297
    esv2672452CNV Deletion23128226
    esv2658053CNV Deletion23128226
    nsv2256CNV Insertion18451855
    nsv513492CNV Insertion21212237

    Human Gene Mutation Database (HGMD): FHOD3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FHOD3
    DNA2.0 Custom Variant and Variant Library Synthesis for FHOD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609691    OMIM disorders: --


    Find genes that share disorders with FHOD3           About GenesLikeMe

    Genetic Association Database (GAD): FHOD3
    Human Genome Epidemiology (HuGE) Navigator: FHOD3 (2 documents)

    Export disorders for FHOD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FHOD3 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with FHOD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PubMed id 20195266)1, 4 Adkins D.E....van den Oord E.J. (Mol. Psychiatry 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. (PubMed id 21149568)1, 2 Iskratsch T.... Ehler E. (J. Cell Biol. 2010)
    5. Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament. (PubMed id 15966898)1, 2 Kanaya H.... Sumimoto H. (Genes Cells 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Identification and characterization of human FHOD3 gene in silico. (PubMed id 15010865)1, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2004)
    8. Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy. (PubMed id 23255317)1 Wooten E.C....Huggins G.S. (Circ Cardiovasc Genet 2013)
    9. Two distinct phosphorylation events govern the function of muscle FHOD3. (PubMed id 23052206)1 Iskratsch T....Ehler E. (Cell. Mol. Life Sci. 2013)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80206 HGNC: 26178 AceView: FHOD3 Ensembl:ENSG00000134775 euGenes: HUgn80206
    ECgene: FHOD3 H-InvDB: FHOD3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1695

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FHOD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FHOD3 gene:
    Search GeneIP for patents involving FHOD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FHOD3  
     OriGene qPCR primer pairs and template standards for FHOD3   OriGene Protein Over-expression Lysate for FHOD3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FHOD3  
     OriGene qSTAR qPCR primer pairs in human, mouse for FHOD3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FHOD3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FHOD3   OriGene Custom Protein Services for FHOD3  

     
     
     Block miRNA regulation of human, mouse, rat FHOD3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FHOD3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FHOD3 Predesigned siRNA for gene silencing in human, mouse, rat FHOD3
     QuantiFast Probe-based Assays in human, mouse, rat FHOD3 QuantiTect SYBR Green Assays in human, mouse, rat FHOD3
     Custom PCR Arrays for FHOD3 Search Chromatin IP Primers for FHOD3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FHOD3  Search GeneGlobe Interaction Network for FHOD3
     Regulatory tfbs in FHOD3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FHOD3 GenScript cDNA clones with any tag delivered in your preferred vector for FHOD3
     GenScript Custom Assay Services for FHOD3 GenScript Custom overexpressing Cell Line Services for FHOD3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FHOD3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FHOD3 antibodies
     FHOD3 lysates
     Antibodies for FHOD3
     See all of Abcam's Antibodies, Kits and Proteins for FHOD3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FHOD3
     Antibodies for FHOD3
     ELISAs for FHOD3
     CLIAs for FHOD3



     Browse ESI BIO Cell Lines and PureStem Progenitors for FHOD3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHOD3
     SwitchGear 3'UTR luciferase reporter plasmids for FHOD3
     SwitchGear Promoter luciferase reporter plasmids for FHOD3
     ThermoFisher Antibodies for FHOD3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FHOD3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FHOD3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FHOD3
     LSBio Antibodies in human, mouse, rat for FHOD3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FHOD3
      Search eBioscience for proteins for FHOD3
      Search eBioscience for elisas for FHOD3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FHOD3 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4