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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FHOD3 Gene

protein-coding   GIFtS: 49
GCID: GC18P033877

formin homology 2 domain containing 3
 Explore 2 diseases affiliated with
FHOD3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FHOD3    

Aliases
for FHOD3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Formin Homology 2 Domain Containing 31 2     FLJ227171
FHOS21 2 3 5     Formactin22
KIAA16951 3 5     FH1/FH2 Domain-Containing Protein 32
Formin Homolog Overexpressed In Spleen 22 3     Formactin-23
HFHOS21     Formactin-23
FLJ222971     

External Ids:    HGNC: 261781   Entrez Gene: 802062   Ensembl: ENSG000001347757   OMIM: 6096915   UniProtKB: Q2V2M93   

Export aliases for FHOD3 gene to outside databases

Previous GC identifers: GC18P032344 GC18P032129 GC18P032131 GC18P030735


Summaries
for FHOD3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FHOD3:
Proteins that contain formin (FMN1; MIM 136535) homology (FH) domains, such as FHOD3, play a role in regulation of the
actin cytoskeleton (Kanaya et al., 2005 (PubMed 15966898)).(supplied by OMIM, Apr 2010)

UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9
Function: Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity).
Isoform 4 may play a role in actin filament polymerization in cardiomyocytes




Genomic Views
for FHOD3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FHOD3 gene promoter:
         NF-1   p53   ATF-2   MyoD   Nkx2-5   Nkx5-1   PPAR-gamma1   POU2F1a   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FHOD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FHOD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FHOD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12   Ensembl cytogenetic band:  18q12.2   HGNC cytogenetic band: 18q12

FHOD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FHOD3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P033877:  view genomic region     (about GC identifiers)

Start:
 33,877,680 bp from pter      End:
 34,360,018 bp from pter
Size:
 482,339 bases      Orientation:
 plus strand

Proteins
for FHOD3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9 (See protein sequence)
Recommended Name: FH1/FH2 domain-containing protein 3  
Size: 1422 amino acids; 158613 Da
Subunit: Interacts with nestin/NES-based interfilament (IF) (By similarity). Interacts with SQSTM1; isoform 4 threonine
phosphorylation disrupts SQSTM1-binding
Subcellular location: Cytoplasm, cytoskeleton. Note=Main part of the protein localizes to actin fibers and the
remaining part displays filamentous staining (By similarity)
Subcellular location: Isoform 4: Cytoplasm, myofibril, sarcomere, Z line. Note=Threonine phosphorylation in isoform
4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes
Sequence caution: Sequence=BAB15292.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15463.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MQT4 E5F5Q0 Q642I2 Q6ZRQ7 Q86TF9 Q8N3A5 Q9C0G8 Q9H604 Q9H6G7
Alternative splicing: 4 isoforms:  Q2V2M9-1   Q2V2M9-2   Q2V2M9-3   Q2V2M9-4   (Phosphorylated at Thr-1474 and Thr-1476 by CK2)

Explore the universe of human proteins at neXtProt for FHOD3: NX_Q2V2M9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q2V2M9

    • FHOD3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079411.2  
    ENSEMBL proteins: 
     ENSP00000466937   ENSP00000352186   ENSP00000464944   ENSP00000467195   ENSP00000468163  
     ENSP00000467462   ENSP00000465843   ENSP00000257209   ENSP00000411430  

    Human Recombinant Protein Products: 
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    Novus Biologicals FHOD3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FHOD3

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IEA--
    GO:0030018Z disc IEA--


    FHOD3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FHOD3

    Protein Domains /
    Families
    for FHOD3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FHOD3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR015425 FH2_actin-bd
     IPR014767 Diaphanous_autoregulatory
     IPR003104 Actin-bd_FH2/DRF_autoreg
     IPR014768 GTPase-bd/formin_homology_3
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q2V2M9

    ProtoNet protein and cluster: Q2V2M9

    1 Blocks protein family: IPB003104 Actin-binding FH2

    UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9
    Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This
    autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain
    to then nucleate and elongate nonbranched actin filaments (By similarity)
    Similarity: Belongs to the formin homology family
    Similarity: Contains 1 DAD (diaphanous autoregulatory) domain
    Similarity: Contains 1 FH1 (formin homology 1) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain
    Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


    Function
    for FHOD3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9
    Function: Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity).
    Isoform 4 may play a role in actin filament polymerization in cardiomyocytes

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate FHOD3 (see all 12):
    hsa-miR-30c hsa-miR-618 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-30a hsa-miR-493* hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FHOD3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FHOD3

    Clone
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    Search LifeMap BioReagents cell lines for FHOD3

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--


    FHOD3 for ontologies           About GeneDecksing


    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fhod3):
     cardiovascular system  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     muscle 

    FHOD3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FHOD3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FHOD3

    1 Interacting protein for FHOD3 (Q2V2M91) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135011EBI-6395505,EBI-307104
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030036actin cytoskeleton organization ----
    GO:0030837negative regulation of actin filament polymerization IEA--
    GO:0045214sarcomere organization IEA--


    FHOD3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FHOD3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FHOD3
    Search CenterWatch for drugs/clinical trials and news about FHOD3 

    Transcripts
    for FHOD3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FHOD3 gene: 
    NM_025135.2  

    Unigene Cluster for FHOD3:

    Formin homology 2 domain containing 3
    Hs.630884  [show with all ESTs]
    Unigene Representative Sequence: NM_025135
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589114 ENST00000590592 ENST00000359247(uc002kzr.1 uc002kzt.1 uc002kzu.1)
    ENST00000586635 ENST00000591635 ENST00000592930 ENST00000587493 ENST00000592128
    ENST00000585579 ENST00000257209(uc002kzs.1 uc021uiv.1) ENST00000445677(uc010dmz.1 uc010dna.1 uc010dnb.1)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FHOD3
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate FHOD3 (see all 12):
    hsa-miR-30c hsa-miR-618 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-30a hsa-miR-493* hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FHOD3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FHOD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FHOD3

    Additional cDNA sequence: 

    AB051482.1 AB084087.1 AK025950.1 AK026370.1 AK091899.1 AK128053.1 AK308859.1 AL834480.1 
    BC031518.1 BC041040.1 BC050670.1 BC058897.1 BC081563.1 BC131751.1 HM191478.1 

    10 DOTS entries:

    DT.214877  DT.97799371  DT.100779061  DT.95182809  DT.75195798  DT.95372571  DT.100713617  DT.100018234 
    DT.121104257  DT.91807843 

    24/109 AceView cDNA sequences (see all 109):

    AL834480 AK025950 BQ721062 BU740907 AA628057 AI250754 BQ018555 AB051482 
    AI686400 AA338649 T33312 BU739165 AK026370 AA744547 BM717357 AI948493 
    F02434 AI948499 AK091899 BC031518 CA429813 BQ014182 BF197115 BU688937 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FHOD3 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                -                 -     -     -     -     -     -                                                                           
    SP2:                                                                                                                                            -               
    SP3:                                                                                                                                                            
    SP4:                                                              -     -     -     -     -                                                                     
    SP5:                                                              -                                                                                             


    ECgene alternative splicing isoforms for FHOD3

    Expression
    for FHOD3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FHOD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCAAATAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FHOD3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/18 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 18) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    Gut TubeForegutForegut Endoderm CellsEndoderm
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    LungTracheaBasal CellsLung
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainCerebral CortexBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)

    See FHOD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FHOD3

    SOURCE GeneReport for Unigene cluster: Hs.630884

    UniProtKB/Swiss-Prot: FHOD3_HUMAN, Q2V2M9
    Tissue specificity: Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases,
    including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as
    ischemic heart disease (at protein level)

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHOD3

    Orthologs
    for FHOD3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FHOD3 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FHOD31 formin homology 2 domain containing 3 77.45(n)
    81.12(a)    		   420952  XM_419037.3  XP_419037.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 88(a)
    57(a)
    (see all 3)    		 1 ↔ many
    1 ↔ many
    (see all 3)    		 6(57752620-57805751)
    6(57816621-57924657)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX683094.12   -- 76.62(n)    BX683094.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1037461 zgc:103746 67.01(n)
    69.51(a)    		   570795  XM_694317.4  XP_699409.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Fhos1 CG42610-PA 54.09(n)
    51.45(a)    		   39004  NM_001169916.1  NP_001163387.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea fhod-16
    		 Formin HOmology Domain family member (fhod-1)
    		 32(a)
    		 possible ortholog
    		 I(5058254-5068832)


    ENSEMBL Gene Tree for FHOD3 (if available)
    TreeFam Gene Tree for FHOD3 (if available) 

    Paralogs
    for FHOD3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FHOD3 gene
    FHOD12  
    1 SIMAP similar gene for FHOD3 using alignment to 5 protein entries:     FHOD3_HUMAN (see all proteins):
    FHOD1

    FHOD3 for paralogs           About GeneDecksing



    Genomic Variants
    for FHOD3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8191 NCBI SNPs in FHOD3 are shown (see all 8191)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs341008901,2
    		C,--31120489(+) TTAAA-/GGCATG 1 -- int13Minor allele frequency- G:0.00NA CSA 8
    rs1152479741,2
    		F,--33875801(+) GGAGGC/TCCCTG 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1870115901,2
    		--33876074(+) CAGGTA/GAGCGG 1 -- us2k10--------
    rs1903173501,2
    		--33876330(+) CAAAAC/TCGGTC 1 -- us2k10--------
    rs1827104391,2
    		--33876405(+) GAAAGC/TAGAGC 1 -- us2k10--------
    rs1869871031,2
    		--33876608(+) CGCCTG/TGAAAA 1 -- us2k10--------
    rs99544371,2
    		C,F,H,--33876647(+) TATGAG/AGGCGA 1 -- us2k15Minor allele frequency- A:0.04NS NA WA 584
    rs1145232551,2
    		F,--33876659(+) CTATAT/CAAGGG 1 -- us2k11Minor allele frequency- C:0.12WA 118
    rs1898590631,2
    		--33876675(+) GAACCA/GGGAAC 1 -- us2k10--------
    rs1821352941,2
    		--33876707(+) GGAGAA/CCCGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FHOD3 (33877680 - 34127680 bp, first 250kb of FHOD3)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 22 variations for FHOD3
         15/19 CNVs (see all 19): 58828 88784 32210 5904 3164 38882 8857 1970 88783 1293 3165 67328 4056 67329 77845
         3 Indels: 88785 88786 77844

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    Disorders / Diseases
    for FHOD3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FHOD3 for disorders           About GeneDecksing

    OMIM gene information: 609691    OMIM disorders: --

    2 diseases for FHOD3:    About MalaCards
    malaria    leukemia

    Human Genome Epidemiology (HuGE) Navigator: FHOD3 (2 documents)

    Export disorders for FHOD3 gene to outside databases

    Publications
    for FHOD3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FHOD3 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with FHOD3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. (PubMed id 21149568)1, 2 Iskratsch T.... Ehler E. (2010)
    3. Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament. (PubMed id 15966898)1, 2 Kanaya H.... Sumimoto H. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Identification and characterization of human FHOD3 gene in silico. (PubMed id 15010865)1, 9 Katoh M. and Katoh M. (2004)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Genomewide pharmacogenomic study of metabolic side ef fects to antipsychotic drugs. (PubMed id 20195266)1 Adkins D.E....van den Oord E.J. (2010)
    8. Mammalian formin fhod3 regulates actin assembly and s arcomere organization in striated muscles. (PubMed id 19706596)1 Taniguchi K....Sumimoto H. (2009)
    9. Acquired variation outweighs inherited variation in w hole genome analysis of methotrexate polyglutamate accumulation in leukemia. (PubMed id 19066393)1 French D....Relling M.V. (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    External Searches for FHOD3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing FHOD3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80206 HGNC: 26178 AceView: FHOD3 Ensembl:ENSG00000134775 euGenes: HUgn80206
    ECgene: FHOD3 H-InvDB: FHOD3

    Other Databases showing FHOD3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1695

    Specialized Databases showing FHOD3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FHOD3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FHOD3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FHOD3 gene:
    Search GeneIP for patents involving FHOD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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