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Aliases for FHOD1 Gene

Aliases for FHOD1 Gene

  • Formin Homology 2 Domain Containing 1 2 3
  • FHOS 3 4 6
  • Formin Homolog Overexpressed In Spleen 1 3 4
  • Formin Homology 2 Domain-Containing Protein 1 4
  • FH1/FH2 Domain-Containing Protein 1 3
  • FHOS1 4

External Ids for FHOD1 Gene

Previous GeneCards Identifiers for FHOD1 Gene

  • GC16M057957
  • GC16M067641
  • GC16M066998
  • GC16M067039
  • GC16M065820
  • GC16M053136

Summaries for FHOD1 Gene

Entrez Gene Summary for FHOD1 Gene

  • This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for FHOD1 Gene

FHOD1 (Formin Homology 2 Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and actin binding. An important paralog of this gene is FHOD3.

UniProtKB/Swiss-Prot for FHOD1 Gene

  • Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.

Gene Wiki entry for FHOD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHOD1 Gene

Genomics for FHOD1 Gene

Regulatory Elements for FHOD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FHOD1 Gene

Start:
67,229,387 bp from pter
End:
67,247,658 bp from pter
Size:
18,272 bases
Orientation:
Minus strand

Genomic View for FHOD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FHOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHOD1 Gene

Proteins for FHOD1 Gene

  • Protein details for FHOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y613-FHOD1_HUMAN
    Recommended name:
    FH1/FH2 domain-containing protein 1
    Protein Accession:
    Q9Y613
    Secondary Accessions:
    • Q59F76
    • Q6Y1F2
    • Q76MS8
    • Q8N521

    Protein attributes for FHOD1 Gene

    Size:
    1164 amino acids
    Molecular mass:
    126551 Da
    Quaternary structure:
    • Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus. Interacts with ROCK1 in a Src-dependent manner.

    Three dimensional structures from OCA and Proteopedia for FHOD1 Gene

neXtProt entry for FHOD1 Gene

Proteomics data for FHOD1 Gene at MOPED

Post-translational modifications for FHOD1 Gene

Other Protein References for FHOD1 Gene

No data available for DME Specific Peptides for FHOD1 Gene

Domains for FHOD1 Gene

Protein Domains for FHOD1 Gene

Suggested Antigen Peptide Sequences for FHOD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y613

UniProtKB/Swiss-Prot:

FHOD1_HUMAN :
  • Q9Y613
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.
  • Contains 1 DAD (diaphanous autoregulatory) domain.
  • Contains 1 FH1 (formin homology 1) domain.
  • Contains 1 FH2 (formin homology 2) domain.
  • Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with FHOD1: view

No data available for Gene Families for FHOD1 Gene

Function for FHOD1 Gene

Molecular function for FHOD1 Gene

UniProtKB/Swiss-Prot Function: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.

Gene Ontology (GO) - Molecular Function for FHOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 15095401
GO:0042802 identical protein binding IPI 18239683
genes like me logo Genes that share ontologies with FHOD1: view

Phenotypes for FHOD1 Gene

genes like me logo Genes that share phenotypes with FHOD1: view

Animal Model Products

CRISPR Products

miRNA for FHOD1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FHOD1 Gene

Localization for FHOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FHOD1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FHOD1 Gene COMPARTMENTS Subcellular localization image for FHOD1 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for FHOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber IDA 15095401
GO:0005634 nucleus IDA 15095401
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
GO:0032059 bleb IEA --
genes like me logo Genes that share ontologies with FHOD1: view

Pathways for FHOD1 Gene

SuperPathways for FHOD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FHOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 15095401
GO:0051496 positive regulation of stress fiber assembly IDA 15095401
genes like me logo Genes that share ontologies with FHOD1: view

No data available for Pathways by source for FHOD1 Gene

Transcripts for FHOD1 Gene

Unigene Clusters for FHOD1 Gene

Formin homology 2 domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FHOD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FHOD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ^
SP1:
SP2: -
SP3:
SP4:
SP5: - - -
SP6: - - -
SP7: - -
SP8:
SP9:
SP10:
SP11:

ExUns: 18a · 18b ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8: - - -
SP9:
SP10:
SP11:

Relevant External Links for FHOD1 Gene

GeneLoc Exon Structure for
FHOD1
ECgene alternative splicing isoforms for
FHOD1

Expression for FHOD1 Gene

mRNA expression in normal human tissues for FHOD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FHOD1 Gene

This gene is overexpressed in Spleen (7.7) and Muscle - Skeletal (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FHOD1 Gene

SOURCE GeneReport for Unigene cluster for FHOD1 Gene Hs.95231

mRNA Expression by UniProt/SwissProt for FHOD1 Gene

Q9Y613-FHOD1_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in spleen
genes like me logo Genes that share expressions with FHOD1: view

In Situ Assay Products

Orthologs for FHOD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FHOD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FHOD1 35
  • 99.43 (n)
  • 99.31 (a)
FHOD1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FHOD1 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FHOD1 35
  • 88.37 (n)
  • 90.07 (a)
FHOD1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fhod1 16
Fhod1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FHOD1 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FHOD1 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 47 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
FHOD1 35
  • 68.26 (n)
  • 65.74 (a)
FHOD1 36
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia FHOD1 36
  • 31 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21717 35
zebrafish
(Danio rerio)
Actinopterygii FHOD1 36
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004873 35
  • 56.12 (n)
  • 50.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fhos 35
  • 57.79 (n)
  • 53.15 (a)
Fhos 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fhod-1 35
  • 48.73 (n)
  • 42.52 (a)
fhod-1 36
  • 24 (a)
OneToMany
C46H11.11b 37
  • 35 (a)
C46H11.11a 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
ManyToMany
Species with no ortholog for FHOD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FHOD1 Gene

ENSEMBL:
Gene Tree for FHOD1 (if available)
TreeFam:
Gene Tree for FHOD1 (if available)

Paralogs for FHOD1 Gene

Paralogs for FHOD1 Gene

Selected SIMAP similar genes for FHOD1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FHOD1: view

Variants for FHOD1 Gene

Sequence variations from dbSNP and Humsavar for FHOD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2271290 -- 67,234,123(+) TGGGC(C/T)CAGCC reference, missense
rs2271291 -- 67,234,246(+) CTGGG(C/G)AGTCC reference, missense
rs3057565 -- 67,236,929(+) TAGTA(-/GATCCACC)CTTTC intron-variant, upstream-variant-2KB
rs3743727 -- 67,236,835(-) CCTGC(C/T)CTACC intron-variant, upstream-variant-2KB
rs3852700 -- 67,237,955(+) CCAGC(C/T)CACTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FHOD1 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680
nsv524492 CNV Loss 19592680
nsv471092 CNV Gain 18288195
nsv457513 CNV Loss 19166990

Relevant External Links for FHOD1 Gene

HapMap Linkage Disequilibrium report
FHOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHOD1 Gene

Disorders for FHOD1 Gene

Relevant External Links for FHOD1

Genetic Association Database (GAD)
FHOD1
genes like me logo Genes that share disorders with FHOD1: view

No data available for UniProtKB/Swiss-Prot for FHOD1 Gene

Publications for FHOD1 Gene

  1. Identification and characterization of a protein containing formin homology (FH1/FH2) domains. (PMID: 10352228) Westendorf J.J. … Hiebert S.W. (Gene 1999) 2 3 4 23
  2. The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway. (PMID: 16112087) Boehm M.B. … Koka S. (Biochem. Biophys. Res. Commun. 2005) 2 3 23
  3. The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells. (PMID: 18239683) Takeya R. … Sumimoto H. (EMBO J. 2008) 3 23
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. Fhos, a mammalian formin, directly binds to F-actin via a region N- terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation. (PMID: 14576350) Takeya R. … Sumimoto H. (J. Cell Sci. 2003) 3 4

Products for FHOD1 Gene

Sources for FHOD1 Gene

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