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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FHOD1 Gene

protein-coding GIFtS: 52
GCID: GC16M067263

formin homology 2 domain containing 1

Explore 5 diseases affiliated with
FHOD1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Formin Homology 2 Domain Containing 1¹ ²
FHOS¹ ² ³ ⁵
Formin Homolog Overexpressed In Spleen 1² ³
FH1/FH2 Domain-Containing Protein 1²
FHOS1³
Formin Homology 2 Domain-Containing Protein 1³

External Ids:	HGNC: 17905¹	Entrez Gene: 29109²	Ensembl: ENSG00000135723⁷	OMIM: 606881⁵	UniProtKB: Q9Y613³

Export aliases for FHOD1 gene to outside databases

Previous GC identifers: GC16M057957 GC16M067641 GC16M066998 GC16M067039 GC16M065820 GC16M053136

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FHOD1:

This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously

expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin

proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like

domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a

predominantly cytoplasmic protein and is expressed in a variety of human cell lines. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FHOD1_HUMAN, Q9Y613

Function: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for

its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.

Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing

Gene Wiki entry for FHOD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FHOD1 gene promoter:
ER-alpha E2F-4 E2F-3a E2F-5 Sp1 Nkx2-5 E2F-2 E2F E2F-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FHOD1 promoter sequence

Search SABiosciences Chromatin IP Primers for FHOD1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FHOD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22

FHOD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FHOD1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M067263: view genomic region (about GC identifiers)

Start:	67,263,290 bp from pter	End:	67,281,561 bp from pter
Size:	18,272 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FHOD1_HUMAN, Q9Y613 (See protein sequence)

Recommended Name: FH1/FH2 domain-containing protein 1

Size: 1164 amino acids; 126551 Da

Subunit: Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of

CD21 via its C-terminus. Interacts with ROCK1 in a Src-dependent manner

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic

1 PDB 3D structure from and Proteopedia for FHOD1:

3DAD (3D)

Secondary accessions: Q59F76 Q6Y1F2 Q76MS8 Q8N521

Explore the universe of human proteins at neXtProt for FHOD1: NX_Q9Y613

Post-translational modifications:

Phosphorylated by ROCK1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y613

FHOD1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_037373.2

ENSEMBL proteins:

ENSP00000258201 ENSP00000456322 ENSP00000462807 ENSP00000462988 ENSP00000458085

ENSP00000464011

Human Recombinant Protein Products for FHOD1:

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	Uscn Proteins for FHOD1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	colocalizes with stress fiber	IDA	15095401
GO:0005634	nucleus	IDA	15095401
GO:0005737	cytoplasm	IDA	--
GO:0032059	bleb	IEA	--

FHOD1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FHOD1 for domains About GeneDecksing

4 InterPro domains/families:

IPR015425 FH2_actin-bd

IPR003104 Actin-bd_FH2/DRF_autoreg

IPR014768 GTPase-bd/formin_homology_3

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q9Y613

ProtoNet protein and cluster: Q9Y613

1 Blocks protein family: IPB003104 Actin-binding FH2

UniProtKB/Swiss-Prot: FHOD1_HUMAN, Q9Y613

Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This

autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain

to then nucleate and elongate nonbranched actin filaments

Similarity: Belongs to the formin homology family

Similarity: Contains 1 DAD (diaphanous autoregulatory) domain

Similarity: Contains 1 FH1 (formin homology 1) domain

Similarity: Contains 1 FH2 (formin homology 2) domain

Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FHOD1_HUMAN, Q9Y613

Function: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for

its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.

Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	15095401

FHOD1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for FHOD1:

Decreased influenza A/WSN/33 r

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FHOD1

miRNA Products:		OriGene 3'-UTR Clone: FHOD1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FHOD1
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		hsa-miR-200c hsa-miR-429 hsa-miR-377 hsa-miR-200b
		SwitchGear 3'UTR luciferase reporter plasmid: FHOD1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHOD1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FHOD1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/768 Interacting proteins for FHOD1 (Q9Y613^{2, 3} ENSP00000258201⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 768)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FHOD1	Q9Y613²	MINT-6492714 MINT-51616 MINT-6492781 MINT-6492656 MINT-51617 MINT-6492758 MINT-6492635 MINT-6492675 MINT-6492694 MINT-6492736
RNF5	Q99942²^,³, ENSP00000364235⁴	MINT-62581 MINT-62755 MINT-62679 I2D: score=5 STRING: ENSP00000364235
YWHAE	P62258²^,³	MINT-7947479 I2D: score=1
RANBP2	P49792²^,³, ENSP00000283195⁴	MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000283195
RAC1	P63000²^,³, ENSP00000348461⁴	MINT-51615 I2D: score=3 STRING: ENSP00000348461

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030036	actin cytoskeleton organization	IEA	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	15095401
GO:0051496	positive regulation of stress fiber assembly	IDA	15095401

FHOD1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FHOD1
Search CenterWatch for drugs/clinical trials and news about FHOD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FHOD1 gene:

NM_013241.2

Unigene Cluster for FHOD1:

Formin homology 2 domain containing 1

Hs.95231 [show with all ESTs]

Unigene Representative Sequence: NM_013241

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000569085 ENST00000258201(uc002esl.3 uc010vjh.1) ENST00000567752(uc010ced.3)

ENST00000567687 ENST00000566006 ENST00000567561 ENST00000567509 ENST00000569888

ENST00000561922 ENST00000568595 ENST00000562266

miRNA Products:		OriGene 3'-UTR Clone: FHOD1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FHOD1
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate FHOD1:
		hsa-miR-200c hsa-miR-429 hsa-miR-377 hsa-miR-200b
		SwitchGear 3'UTR luciferase reporter plasmid: FHOD1 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: FHOD1 (NM_013241)
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Additional cDNA sequence:

AB041046.1 AF113615.1 AK025992.1 AK301157.1 AK304232.1 AY192154.1 BC033084.1 U23861.1

9 DOTS entries:

DT.443942 DT.97763521 DT.100779033 DT.100779034 DT.100779032 DT.120726262 DT.91668787 DT.91762509

DT.95291737

24/202 AceView cDNA sequences (see all 202):

AB041046 BQ220832 AA551911 CA417507 CB153759 CB152730 BM789879 BM823742

CR612089 CK822664 N74174 CR620559 CA444268 BU522109 AL046433 AA609867

BQ669260 AK025992 BU689676 CK822665 BU071347 BM989027 BU543780 BG253152

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for FHOD1 (see all 11) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	^	16a	·	16b	·	16c	^	17a	·	17b	^
SP1:
SP2:									-
SP3:
SP4:
SP5:																																									-		-		-

ExUns:	18a	·	18b	^	19a	·	19b	·	19c	^	20a	·	20b	^	21	^	22	^	23
SP1:					-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for FHOD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FHOD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTGAGCT

About this image

FHOD1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Bone

Zeugopod Periosteum

Bone

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See FHOD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FHOD1

SOURCE GeneReport for Unigene cluster: Hs.95231

UniProtKB/Swiss-Prot: FHOD1_HUMAN, Q9Y613

Tissue specificity: Ubiquitous. Highly expressed in spleen

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FHOD1 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FHOD1¹	formin homology 2 domain containing 1	64.16(n) 60.06(a)		415672 NM_001012774.1 NP_001012792.1
lizard (Anolis carolinensis)	Reptilia	FHOD1⁶	--	32(a)	possible ortholog	GL344157.1(13339-62717)
African clawed frog (Xenopus laevis)	Amphibia	Xl.21717²	Xenopus laevis transcribed sequence with weak similarity more	73.17(n)		CA790252.1
zebrafish (Danio rerio)	Actinopterygii	im:7148468¹	im:7148468	60.27(n) 57.87(a)		503946 XM_003198971.1 XP_003199019.1
fruit fly (Drosophila melanogaster)	Insecta	Fhos⁶	--	18(a)	1 → many	3L(8746719-8791819)
worm (Caenorhabditis elegans)	Secernentea	C46H11.11a³ fhod-1¹	Protein FHOD-1¹	35(a) (best of 2)³ 46.74(n)¹ 39.92(a)¹		I(5058624-5061922)³ 172133¹ NM_059112.2¹ NP_491513.2¹

ENSEMBL Gene Tree for FHOD1 (if available)
TreeFam Gene Tree for FHOD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FHOD1 gene

FHOD3²

1 SIMAP similar gene for FHOD1 using alignment to 6 protein entries: FHOD1_HUMAN (see all proteins):

FHOD3

FHOD1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7206105^1,2	C,H	--	53137633(+)	`ATTGTC/TTGAGG`	1	--	int¹		6		NS EA NA	422
rs34590217^1,2	C	--	53137788(+)	`ATGCTT/CGGCCA`	2	/K /E	mis¹		1		NA	76
rs9935067^1,2	C,F	--	53139899(+)	`cagctC/Aatttt`	1	--	int¹		2		NA WA	4
rs116005106^1,2	C,F	--	53140482(+)	`TGATCC/TCTTGT`	1	--	int¹		1		WA	118
rs2271290^1,2	C	--	53141100(+)	`TGGGCC/TCAGCC`	2	E G	mis¹		0	--	--	--	--
rs2271291^1,2	C,H	--	53141223(+)	`CTGGGG/CAGTCC`	2	/S /C	mis¹ ese³		5		EA NS	1908
rs74797779^1,2		--	53141597(+)	`CCACAC/ACCCCC`	1	--	int¹		2		NA	122
rs77703994^1,2		--	53141602(+)	`CCCCCC/GCCAAG`	1	--	int¹		0	--	--	--	--
rs7342763^1,2	C	--	53141603(+)	`CCCCCC/GCAAGG`	1	--	int¹		0	--	--	--	--
rs56026046^1,2	C,F	--	53143402(+)	`GCAGTT/GTGGTG`	1	--	int¹		3		WA	122

HapMap Linkage Disequilibrium report for FHOD1 (67263290 - 67281561 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FHOD1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FHOD1

DNA2.0 Custom Variant and Variant Library Synthesis for FHOD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FHOD1 for disorders           About GeneDecksing

OMIM gene information: 606881    OMIM disorders: --

5 diseases for FHOD1:    About MalaCards

bronchiolitis obliterans organizing pneumonia bronchiolitis obliterans bronchiolitis pneumonia

malaria

Export disorders for FHOD1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FHOD1 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with FHOD1)

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Identification and characterization of a protein containing formin homology (FH1/FH2) domains. (PubMed id 10352228)^{1, 2, 3, 9} Westendorf J.J.... Hiebert S.W. (1999)
The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway. (PubMed id 16112087)^{1, 3, 9} Boehm M.B....Koka S. (2005)
The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing. (PubMed id 18694941)^{1, 2} Hannemann S....Fackler O.T. (2008)
Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1. (PubMed id 16361249)^{1, 2} Schonichen A....Geyer M. (2006)
FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation. (PubMed id 15878344)^{1, 2} Gasteier J.E....Fackler O.T. (2005)
EBV attachment stimulates FHOS/FHOD1 redistribution and co- aggregation with CD21: formin interactions with the cytoplasmic domain of human CD21. (PubMed id 15138285)^{1, 2} Gill M.B.... Fingeroth J.D. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Fhos, a mammalian formin, directly binds to F-actin via a region N- terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation. (PubMed id 14576350)^{1, 2} Takeya R. and Sumimoto H. (2003)
Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells. (PubMed id 15051728)^{1, 9} Wang Y....Mendelsohn M.E. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 29109	HGNC: 17905	AceView: FHOD1	Ensembl:ENSG00000135723	euGenes: HUgn29109
ECgene: FHOD1	H-InvDB: FHOD1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FHOD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FHOD1 gene
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formin homology 2 domain containing 1

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formin homology 2 domain containing 1

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