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FHOD1 Gene

protein-coding   GIFtS: 54
GCID: GC16M067263

Formin Homology 2 Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Formin Homology 2 Domain Containing 11 2
FHOS2 3 5
Formin Homolog Overexpressed In Spleen 12 3
FH1/FH2 Domain-Containing Protein 12
FHOS13
Formin Homology 2 Domain-Containing Protein 13

External Ids:    HGNC: 179051   Entrez Gene: 291092   Ensembl: ENSG000001357237   OMIM: 6068815   UniProtKB: Q9Y6133   

Export aliases for FHOD1 gene to outside databases

Previous GC identifers: GC16M057957 GC16M067641 GC16M066998 GC16M067039 GC16M065820 GC16M053136


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FHOD1 Gene:
This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is
ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to
diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil
domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA
phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell
lines. (provided by RefSeq, Jul 2008)

GeneCards Summary for FHOD1 Gene:
FHOD1 (formin homology 2 domain containing 1) is a protein-coding gene. GO annotations related to this gene include actin binding and identical protein binding. An important paralog of this gene is FHOD3.

UniProtKB/Swiss-Prot: FHOD1_HUMAN, Q9Y613
Function: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade
for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell
elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing

Gene Wiki entry for FHOD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FHOD1 gene promoter:
         ER-alpha   E2F-4   E2F-3a   E2F-5   Sp1   Nkx2-5   E2F-2   E2F   E2F-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFHOD1 promoter sequence
   Search Chromatin IP Primers for FHOD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FHOD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22

FHOD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FHOD1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067263:  view genomic region     (about GC identifiers)

Start:
67,263,290 bp from pter      End:
67,281,561 bp from pter
Size:
18,272 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FHOD1_HUMAN, Q9Y613 (See protein sequence)
Recommended Name: FH1/FH2 domain-containing protein 1  
Size: 1164 amino acids; 126551 Da
Subunit: Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain
of CD21 via its C-terminus. Interacts with ROCK1 in a Src-dependent manner
1 PDB 3D structure from and Proteopedia for FHOD1:
3DAD (3D)    
Secondary accessions: Q59F76 Q6Y1F2 Q76MS8 Q8N521

Explore the universe of human proteins at neXtProt for FHOD1: NX_Q9Y613

Explore proteomics data for FHOD1 at MOPED

Post-translational modifications: 

  • Phosphorylated by ROCK11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FHOD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037373.2  
    ENSEMBL proteins: 
     ENSP00000258201   ENSP00000462807   ENSP00000462988   ENSP00000458085   ENSP00000464011  

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    antibodies-online proteins for FHOD1 (2 products) 

     
    antibodies-online peptides for FHOD1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR015425 FH2_Formin
     IPR014768 GTPase-bd/formin_homology_3
     IPR016024 ARM-type_fold
     IPR027651 FHOD1/FHOD3

    Graphical View of Domain Structure for InterPro Entry Q9Y613

    ProtoNet protein and cluster: Q9Y613

    1 Blocks protein domain: IPB003104 Actin-binding FH2

    UniProtKB/Swiss-Prot: FHOD1_HUMAN, Q9Y613
    Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This
    autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2
    domain to then nucleate and elongate nonbranched actin filaments
    Similarity: Belongs to the formin homology family
    Similarity: Contains 1 DAD (diaphanous autoregulatory) domain
    Similarity: Contains 1 FH1 (formin homology 1) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain
    Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


    Find genes that share domains with FHOD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FHOD1_HUMAN, Q9Y613
    Function: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade
    for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell
    elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI15095401
    GO:0042802identical protein binding IPI18239683
         
    Find genes that share ontologies with FHOD1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FHOD1:
     Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FHOD1

    miRNA
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    miRTarBase miRNAs that target FHOD1:
    hsa-mir-149-5p (MIRT045468), hsa-mir-92a-3p (MIRT049791), hsa-mir-423-5p (MIRT038061), rno-mir-200c-3p (MIRT006618)

    Block miRNA regulation of human, mouse, rat FHOD1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate FHOD1:
    hsa-miR-200c hsa-miR-429 hsa-miR-377 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidFHOD1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FHOD1_HUMAN, Q9Y613: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725colocalizes with stress fiber IDA15095401
    GO:0005634nucleus IDA15095401
    GO:0005737cytoplasm IDA--
    GO:0032059bleb IEA--

    Find genes that share ontologies with FHOD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FHOD1
    Interactions:

        GeneGlobe Interaction Network for FHOD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FHOD1 (Q9Y6131, 2, 3 ENSP000002582014) via UniProtKB, MINT, STRING, and/or I2D (see all 810)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF5Q999422, 3, ENSP000003642354MINT-62581 MINT-62755 MINT-62679 I2D: score=5 STRING: ENSP00000364235
    FHOD1Q9Y6131, 2EBI-348433,EBI-348433 MINT-6492714 MINT-51616 MINT-6492781 MINT-6492656 MINT-51617 MINT-6492758 MINT-6492635 MINT-6492675 MINT-6492694 MINT-6492736
    ENSG00000183574Q999422, 3MINT-62581 MINT-62755 MINT-62679 I2D: score=5 
    ENSG00000223767Q999422, 3MINT-62581 MINT-62755 MINT-62679 I2D: score=5 
    ENSG00000225452Q999422, 3MINT-62581 MINT-62755 MINT-62679 I2D: score=5 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007015actin filament organization ----
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA15095401
    GO:0051496positive regulation of stress fiber assembly IDA15095401

    Find genes that share ontologies with FHOD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FHOD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FHOD1 gene: 
    NM_013241.2  

    Unigene Cluster for FHOD1:

    Formin homology 2 domain containing 1
    Hs.95231  [show with all ESTs]
    Unigene Representative Sequence: NM_013241
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569085 ENST00000258201(uc002esl.3 uc010vjh.1) ENST00000567752(uc010ced.3)
    ENST00000566006 ENST00000567561 ENST00000567509 ENST00000569888 ENST00000561922
    ENST00000568595 ENST00000562266
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    hsa-miR-200c hsa-miR-429 hsa-miR-377 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidFHOD1 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat FHOD1

    Additional mRNA sequence: 

    AB041046.1 AF113615.1 AK025992.1 AK301157.1 AK304232.1 AY192154.1 BC033084.1 U23861.1 

    9 DOTS entries:

    DT.443942  DT.97763521  DT.100779033  DT.100779034  DT.100779032  DT.120726262  DT.91668787  DT.91762509 
    DT.95291737 

    Selected AceView cDNA sequences (see all 202):

    N74174 BU543780 AI963412 BG253152 CR620559 CA417507 BU689676 CK822665 
    BC033084 BG055077 BQ016430 BF001385 BM789879 BM981431 AI962009 BQ014998 
    BE388876 BQ672525 BQ669260 BU160112 CR612089 AA513661 AI090048 AK025992 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FHOD1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ^
    SP1:                                                                                                                                                            
    SP2:                          -                                                                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                          -     -     -                     

    ExUns: 18a · 18b ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22 ^ 23
    SP1:              -                                             
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for FHOD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FHOD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTGAGCT
    FHOD1 Expression
    About this image


    FHOD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Spinal Cord (Nervous System)
     
     Brain (Nervous System)
     
     Spleen (Hematopoietic System)
    FHOD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FHOD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.95231

    UniProtKB/Swiss-Prot: FHOD1_HUMAN, Q9Y613
    Tissue specificity: Ubiquitous. Highly expressed in spleen

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FHOD1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fhod15 formin homology 2 domain containing 1   --   8 (53.04 cM) 105329163 
    chicken
    (Gallus gallus)
    Aves FHOD11 formin homology 2 domain containing 1 68.26(n)
    65.74(a)
      415672  NM_001012774.1  NP_001012792.1 
    lizard
    (Anolis carolinensis)
    Reptilia FHOD16
    formin homology 2 domain containing 1
    31(a)
    1 ↔ 1
    GL344157.1(13212-62717)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.217172 Xenopus laevis transcribed sequence with weak similarity more 73.17(n)    CA790252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii FHOD16
    formin homology 2 domain containing 1
    37(a)
    1 ↔ 1
    7(36004057-36071625) ENSDARG00000051768
    fruit fly
    (Drosophila melanogaster)
    Insecta Fhos1 Fhos 57.79(n)
    53.15(a)
      39004  NM_168293.3  NP_729410.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C46H11.11a3
    fhod-11
    fhod-11 35(a)
    (best of 2)3
    48.73(n)1
    42.52(a)1
      I(5058624-5061922)3
    1721331  NM_059112.31  NP_491513.21 


    ENSEMBL Gene Tree for FHOD1 (if available)
    TreeFam Gene Tree for FHOD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FHOD1 gene
    FHOD32  
    1 SIMAP similar gene for FHOD1 using alignment to 5 protein entries:     FHOD1_HUMAN (see all proteins):
    FHOD3

    Find genes that share paralogs with FHOD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FHOD1 (see all 472)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1995328251,2
    C--68269205(+) TGAAGC/TGGTTA 1 -- ds50010--------
    rs1146627631,2
    C,F--68269232(+) GGCCAA/C/GAGGCC 1 -- ds50011WA 118
    rs1116364961,2
    F--68269341(+) ACTTAC/TACTCT 1 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs745137571,2
    F--68269375(+) TAGAAT/AGTGGC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs124474261,2
    H--68269522(+) CTCCGT/AGCGTT 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420
    rs1870313521,2
    --68269573(+) ACACAA/CATACA 1 -- ut310--------
    rs1505224671,2
    --68269672(+) GCCCTC/TCTCAC 1 -- ut310--------
    rs124480251,2
    C,H--68269682(+) CTCTGT/ACATCT 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420
    rs2017257961,2
    --68269710(+) GGTCCA/GGATAG 1 -- ut310--------
    rs1408815911,2
    F--68269763(+) TTGCTT/CAGTCC 2 /L syn11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for FHOD1 (67263290 - 67281561 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for FHOD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2888n71CNV Loss21882294
    nsv906803CNV Loss21882294
    dgv2886n71CNV Loss21882294
    nsv524492CNV Loss19592680
    nsv827707CNV Loss20364138
    nsv457513CNV Loss19166990
    dgv2885n71CNV Loss21882294
    nsv524363CNV Loss19592680
    nsv471092CNV Gain18288195
    nsv522852CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FHOD1
    DNA2.0 Custom Variant and Variant Library Synthesis for FHOD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606881    OMIM disorders: --


    Find genes that share disorders with FHOD1           About GenesLikeMe

    Genetic Association Database (GAD): FHOD1

    Export disorders for FHOD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FHOD1 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with FHOD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a protein containing formin homology (FH1/FH2) domains. (PubMed id 10352228)1, 2, 3, 9 Westendorf J.J.... Hiebert S.W. (Gene 1999)
    2. The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway. (PubMed id 16112087)1, 3, 9 Boehm M.B....Koka S. (Biochem. Biophys. Res. Commun. 2005)
    3. The diaphanous-related formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing. (PubMed id 18694941)1, 2 Hannemann S.... Fackler O.T. (J. Biol. Chem. 2008)
    4. Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1. (PubMed id 16361249)1, 2 Schonichen A....Geyer M. (J. Biol. Chem. 2006)
    5. FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation. (PubMed id 15878344)1, 2 Gasteier J.E....Fackler O.T. (Exp. Cell Res. 2005)
    6. EBV attachment stimulates FHOS/FHOD1 redistribution and co- aggregation with CD21: formin interactions with the cytoplasmic domain of human CD21. (PubMed id 15138285)1, 2 Gill M.B.... Fingeroth J.D. (J. Cell Sci. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    9. Fhos, a mammalian formin, directly binds to F-actin via a region N- terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation. (PubMed id 14576350)1, 2 Takeya R. and Sumimoto H. (J. Cell Sci. 2003)
    10. Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells. (PubMed id 15051728)1, 9 Wang Y....Mendelsohn M.E. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29109 HGNC: 17905 AceView: FHOD1 Ensembl:ENSG00000135723 euGenes: HUgn29109
    ECgene: FHOD1 H-InvDB: FHOD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FHOD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FHOD1 gene:
    Search GeneIP for patents involving FHOD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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