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Aliases for FHL5 Gene

Aliases for FHL5 Gene

  • Four And A Half LIM Domains 5 2 3
  • ACT 3 4 6
  • Activator Of CAMP-Responsive Element Modulator In Testis 3 4
  • Activator Of CREM In Testis 3 4
  • FHL-5 3 4
  • Activator Of CAMP-Responsive Element Modulator (CREM) In Testis 3
  • Four And A Half LIM Domains Protein 5 3
  • LIM Protein ACT 3
  • 1700027G07Rik 3
  • DJ393D12.2 3

External Ids for FHL5 Gene

Previous GeneCards Identifiers for FHL5 Gene

  • GC06P097056
  • GC06P097117
  • GC06P094444

Summaries for FHL5 Gene

Entrez Gene Summary for FHL5 Gene

  • The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2009]

GeneCards Summary for FHL5 Gene

FHL5 (Four And A Half LIM Domains 5) is a Protein Coding gene. Diseases associated with FHL5 include hemophagocytic lymphohistiocytosis, familial, 5. Among its related pathways are Transcription_CREM signaling in testis. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for FHL5 Gene

  • May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.

Gene Wiki entry for FHL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHL5 Gene

Genomics for FHL5 Gene

Regulatory Elements for FHL5 Gene

Genomic Location for FHL5 Gene

Start:
96,562,548 bp from pter
End:
96,619,930 bp from pter
Size:
57,383 bases
Orientation:
Plus strand

Genomic View for FHL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FHL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHL5 Gene

Proteins for FHL5 Gene

  • Protein details for FHL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TD97-FHL5_HUMAN
    Recommended name:
    Four and a half LIM domains protein 5
    Protein Accession:
    Q5TD97
    Secondary Accessions:
    • B2RBD1
    • E1P526
    • Q5TD98
    • Q8WW21
    • Q9NQU2

    Protein attributes for FHL5 Gene

    Size:
    284 amino acids
    Molecular mass:
    32720 Da
    Quaternary structure:
    • Interacts with CREM via the third LIM domain.

    Three dimensional structures from OCA and Proteopedia for FHL5 Gene

neXtProt entry for FHL5 Gene

Proteomics data for FHL5 Gene at MOPED

Post-translational modifications for FHL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FHL5 Gene

No data available for DME Specific Peptides for FHL5 Gene

Domains for FHL5 Gene

Protein Domains for FHL5 Gene

Suggested Antigen Peptide Sequences for FHL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TD97

UniProtKB/Swiss-Prot:

FHL5_HUMAN :
  • Q5TD97
Domain:
  • Contains 4 LIM zinc-binding domains.
genes like me logo Genes that share domains with FHL5: view

No data available for Gene Families for FHL5 Gene

Function for FHL5 Gene

Molecular function for FHL5 Gene

UniProtKB/Swiss-Prot Function: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.

Gene Ontology (GO) - Molecular Function for FHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding IPI 23088713
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with FHL5: view

Phenotypes for FHL5 Gene

MGI mutant phenotypes for FHL5:
inferred from 1 alleles
GenomeRNAi human phenotypes for FHL5:
genes like me logo Genes that share phenotypes with FHL5: view

Animal Models for FHL5 Gene

MGI Knock Outs for FHL5:

Animal Model Products

CRISPR Products

miRNA for FHL5 Gene

miRTarBase miRNAs that target FHL5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FHL5 Gene

Localization for FHL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FHL5 Gene

Nucleus. Note=Nuclei of round and elongated spermatids.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FHL5 Gene COMPARTMENTS Subcellular localization image for FHL5 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for FHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FHL5: view

Pathways for FHL5 Gene

genes like me logo Genes that share pathways with FHL5: view

Pathways by source for FHL5 Gene

1 GeneGo (Thomson Reuters) pathway for FHL5 Gene

Gene Ontology (GO) - Biological Process for FHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with FHL5: view

Transcripts for FHL5 Gene

Unigene Clusters for FHL5 Gene

Four and a half LIM domains 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FHL5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FHL5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: -

Relevant External Links for FHL5 Gene

GeneLoc Exon Structure for
FHL5
ECgene alternative splicing isoforms for
FHL5

Expression for FHL5 Gene

mRNA expression in normal human tissues for FHL5 Gene

mRNA differential expression in normal tissues according to GTEx for FHL5 Gene

This gene is overexpressed in Artery - Tibial (19.7) and Artery - Coronary (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FHL5 Gene

SOURCE GeneReport for Unigene cluster for FHL5 Gene Hs.632608

mRNA Expression by UniProt/SwissProt for FHL5 Gene

Q5TD97-FHL5_HUMAN
Tissue specificity: Testis-specific (at protein level).
genes like me logo Genes that share expressions with FHL5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FHL5 Gene

Orthologs for FHL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FHL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FHL5 35
  • 99.18 (n)
  • 99.3 (a)
FHL5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FHL5 35
  • 90.61 (n)
  • 89.44 (a)
FHL5 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FHL5 35
  • 90.73 (n)
  • 89.44 (a)
FHL5 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fhl5 35
  • 86.34 (n)
  • 85.51 (a)
Fhl5 16
Fhl5 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FHL5 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fhl5 35
  • 86.03 (n)
  • 86.62 (a)
chicken
(Gallus gallus)
Aves FHL5 35
  • 73 (n)
  • 67.38 (a)
FHL5 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FHL5 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fhl5 35
  • 67.14 (n)
  • 61.43 (a)
Str.13651 35
zebrafish
(Danio rerio)
Actinopterygii fhl5 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lim-9 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for FHL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FHL5 Gene

ENSEMBL:
Gene Tree for FHL5 (if available)
TreeFam:
Gene Tree for FHL5 (if available)

Paralogs for FHL5 Gene

Selected SIMAP similar genes for FHL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FHL5: view

Variants for FHL5 Gene

Sequence variations from dbSNP and Humsavar for FHL5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs211158 -- 96,575,062(+) TTTAG(C/G)TGAGC intron-variant
rs211159 -- 96,575,150(+) TTAAC(A/G)AAAGT intron-variant
rs211160 -- 96,575,194(+) TCCCC(A/G)TCTCT intron-variant
rs211161 -- 96,614,917(+) TCACG(G/T)GATAA intron-variant
rs211162 -- 96,619,468(+) GTTAC(A/G)GTATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FHL5 Gene

Variant ID Type Subtype PubMed ID
nsv886424 CNV Loss 21882294
nsv507350 CNV Insertion 20534489
esv267790 CNV Insertion 20981092

Relevant External Links for FHL5 Gene

HapMap Linkage Disequilibrium report
FHL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHL5 Gene

Disorders for FHL5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FHL5 Gene including...

Search for FHL5 Gene in MalaCards »

Relevant External Links for FHL5

Genetic Association Database (GAD)
FHL5
Human Genome Epidemiology (HuGE) Navigator
FHL5
genes like me logo Genes that share disorders with FHL5: view

No data available for UniProtKB/Swiss-Prot for FHL5 Gene

Publications for FHL5 Gene

  1. Cloning and expression of activator of CREM in testis in human testicular tissue. (PMID: 11327716) Palermo I. … Travali S. (Biochem. Biophys. Res. Commun. 2001) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males. (PMID: 16687568) Christensen G.L. … Carrell D.T. (Mol. Hum. Reprod. 2006) 3 48

Products for FHL5 Gene

Sources for FHL5 Gene

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