Aliases for FHL5 Gene
Aliases for FHL5 Gene
External Ids for FHL5 Gene
- HGNC: 17371
- Entrez Gene: 9457
- Ensembl: ENSG00000112214
- OMIM: 605126
- UniProtKB: Q5TD97
Previous GeneCards Identifiers for FHL5 Gene
- GC06P097056
- GC06P097117
- GC06P094444
Summaries for FHL5 Gene
-
The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]
GeneCards Summary for FHL5 Gene
FHL5 (Four And A Half LIM Domains 5) is a Protein Coding gene. Among its related pathways are Transcription_CREM signaling in testis. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is FHL2.
UniProtKB/Swiss-Prot for FHL5 Gene
-
May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHL5 Gene
Genomics for FHL5 Gene
Regulatory Elements for FHL5 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G096014 | 0.7 | ENCODE | 5.6 | -546.7 | -546707 | 1.8 | ZNF202 GTF2F1 CTCF MXI1 CEBPB CHD1 CBX2 CEBPG RBBP5 E2F1 | FHL5 FUT9 KRT18P50 |
- Transcription factor binding sites by QIAGEN in the FHL5 gene promoter:
Regulatory Element Products
Genomic Location for FHL5 Gene
- Chromosome:
- 6
- Start:
- 96,562,548 bp from pter
- End:
- 96,618,620 bp from pter
- Size:
- 56,073 bases
- Orientation:
- Plus strand
Genomic View for FHL5 Gene
- Cytogenetic band:
-
- 6q16.1 by Ensembl
- 6q16.1 by Entrez Gene
- 6q16.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FHL5 Gene
Proteins for FHL5 Gene
-
Protein details for FHL5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5TD97-FHL5_HUMAN
- Recommended name:
- Four and a half LIM domains protein 5
- Protein Accession:
- Q5TD97
- B2RBD1
- E1P526
- Q5TD98
- Q8WW21
- Q9NQU2
Protein attributes for FHL5 Gene
- Size:
- 284 amino acids
- Molecular mass:
- 32720 Da
- Quaternary structure:
-
- Interacts with CREM (via the third LIM domain). Interacts (via second LIM domain) with SPAG8.
Protein Expression for FHL5 Gene
Post-translational modifications for FHL5 Gene
Other Protein References for FHL5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FHL5
-
Abcam antibodies for FHL5
- Invitrogen Antibodies for FHL5
- antibodies-online Antibodies for FHL5: See all 35
- GeneTex FHL5 antibody for FHL5
-
Santa Cruz Biotechnology (SCBT) Antibodies for FHL5
Protein Products
-
OriGene Purified Proteins for FHL5
- Search Origene for MassSpec and Protein Over-expression Lysates for FHL5
- Origene Custom Protein Services for FHL5
- antibodies-online Proteins for FHL5: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FHL5
-
Abcam proteins for FHL5
Assay Products
No data available for DME Specific Peptides for FHL5 Gene
Domains & Families for FHL5 Gene
Gene Families for FHL5 Gene
Protein Domains for FHL5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FHL5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FHL5 Gene
Function for FHL5 Gene
Molecular function for FHL5 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for FHL5 Gene
- MGI mutant phenotypes for FHL5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FHL5:
Animal Models for FHL5 Gene
- MGI Knock Outs for FHL5:
-
- Fhl5 tm1Saco
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FHL5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FHL5 gene
- Search ViGene Biosciences for FHL5
CRISPR Products
-
OriGene CRISPR knockouts for FHL5
-
Santa Cruz Biotechnology (SCBT) CRISPR for FHL5
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miRNA for FHL5 Gene
- miRTarBase miRNAs that target FHL5
miRNA Products
- Search ViGene Biosciences for FHL5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FHL5
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-
ViGene Biosciences ready-to-package AAV shRNAs for FHL5 gene
Clone Products
- Sino Biological Human cDNA Clone for FHL5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FHL5
-
ViGene Biosciences adenoviral particle packaged cDNA for FHL5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FHL5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FHL5 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FHL5 Gene
Localization for FHL5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FHL5 Gene
- Nucleus. Note=Nuclei of round and elongated spermatids.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for FHL5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcription_CREM signaling in testis | ||
Pathways by source for FHL5 Gene
1 GeneGo (Thomson Reuters) pathway for FHL5 Gene
Interacting Proteins for FHL5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | IEA | -- |
No data available for SIGNOR curated interactions for FHL5 Gene
Transcripts for FHL5 Gene
mRNA/cDNA for FHL5 Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (51) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FHL5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FHL5
-
Santa Cruz Biotechnology (SCBT) CRISPR for FHL5
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miRNA Products
- Search ViGene Biosciences for FHL5
Inhibitory RNA Products
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-
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Clone Products
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||
| SP6: | - |
Expression for FHL5 Gene
mRNA differential expression in normal tissues according to GTEx for FHL5 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FHL5 Gene
NURSA nuclear receptor signaling pathways regulating expression of FHL5 Gene:
FHL5SOURCE GeneReport for Unigene cluster for FHL5 Gene:
Hs.632608mRNA Expression by UniProt/SwissProt for FHL5 Gene:
Q5TD97-FHL5_HUMANPrimer Products
-
OriGene qPCR primer pairs for FHL5
-
OriGene qPCR primer pairs and template standards for FHL5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FHL5 Gene
Orthologs for FHL5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FHL5 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FHL5 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FHL5 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fhl5 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fhl5 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FHL5 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FHL5 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FHL5 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fhl5 34 |
|
||
| Str.13651 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | fhl5 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | lim-9 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for FHL5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FHL5 Gene
Paralogs for FHL5 Gene
(4) SIMAP similar genes for FHL5 Gene using alignment to 1 proteins:
Variants for FHL5 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000030124 | -- | 96,598,063(+) | GTTAG(C/T)CTTTC | intron-variant | |
| rs1000036928 | -- | 96,562,659(+) | CCCAA(A/G)AAGGG | upstream-variant-2KB, utr-variant-5-prime | |
| rs1000038772 | -- | 96,577,475(+) | CCACA(C/G)ATGTA | intron-variant | |
| rs1000044067 | -- | 96,591,104(+) | CCAGA(A/G)CATGT | intron-variant | |
| rs1000096227 | -- | 96,561,445(+) | CGGGA(G/T)ACAGG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3439889 | CNV | insertion | 20981092 |
| nsv507350 | OTHER | sequence alteration | 20534489 |
Relevant External Links for FHL5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FHL5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHL5 Gene
Disorders for FHL5 Gene
Relevant External Links for FHL5
No disorders were found for FHL5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FHL5 Gene
Publications for FHL5 Gene
- A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. (PMID: 22319020) Davies R.W. … McPherson R. (Circ Cardiovasc Genet 2012) 3 46 64
- Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 46 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- A SNP in the ACT gene associated with astrocytosis and rapid cognitive decline in AD. (PMID: 17368652) Belbin O. … Morgan K. (Neurobiol. Aging 2008) 3 46 64
- Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males. (PMID: 16687568) Christensen G.L. … Carrell D.T. (Mol. Hum. Reprod. 2006) 3 46 64
Products for FHL5 Gene
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- antibodies-online Antibodies for FHL5: See all 35
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- antibodies-online Proteins for FHL5: See all 5
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- GeneTex FHL5 antibody for FHL5
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FHL5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




