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FHL5 Gene

protein-coding   GIFtS: 55
GCID: GC06P097056

Four And A Half LIM Domains 5

  See FHL5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Four And A Half LIM Domains 51 2     1700027G07Rik2
ACT2 3 5     Activator Of CAMP-Responsive Element Modulator (CREM) In Testis2
Activator Of CAMP-Responsive Element Modulator In Testis2 3     dJ393D12.22
Activator Of CREM In Testis2 3     Four And A Half LIM Domains Protein 52
FHL-52 3     LIM Protein ACT2

External Ids:    HGNC: 173711   Entrez Gene: 94572   Ensembl: ENSG000001122147   OMIM: 6051265   UniProtKB: Q5TD973   

Export aliases for FHL5 gene to outside databases

Previous GC identifers: GC06P097117 GC06P094444


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FHL5 Gene:
The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator
(CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a
transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple
polyadenylation sites found in this gene. Alternative splicing results in multiple transcript variants encoding
the same protein. (provided by RefSeq, Dec 2009)

GeneCards Summary for FHL5 Gene:
FHL5 (four and a half LIM domains 5) is a protein-coding gene. Diseases associated with FHL5 include familial hemophagocytic lymphohistiocytosis 5. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is LIMS1.

UniProtKB/Swiss-Prot: FHL5_HUMAN, Q5TD97
Function: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a
phosphorylation-independent manner

Gene Wiki entry for FHL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FHL5 gene promoter:
         STAT5B   STAT5A   Nkx2-5   LCR-F1   Evi-1   RORalpha1   Pax-3   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFHL5 promoter sequence
   Search Chromatin IP Primers for FHL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FHL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.1-q16.3   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.1-q16.3

FHL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FHL5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P097056:  view genomic region     (about GC identifiers)

Start:
97,010,424 bp from pter      End:
97,064,512 bp from pter
Size:
54,089 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FHL5_HUMAN, Q5TD97 (See protein sequence)
Recommended Name: Four and a half LIM domains protein 5  
Size: 284 amino acids; 32720 Da
Subunit: Interacts with CREM via the third LIM domain (By similarity)
1 PDB 3D structure from and Proteopedia for FHL5:
1X68 (3D)    
Secondary accessions: B2RBD1 E1P526 Q5TD98 Q8WW21 Q9NQU2

Explore the universe of human proteins at neXtProt for FHL5: NX_Q5TD97

Explore proteomics data for FHL5 at MOPED


See FHL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001164278.1  NP_065228.4  

ENSEMBL proteins: 
 ENSP00000396390   ENSP00000326022   ENSP00000442357  

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antibodies-online proteins for FHL5 (4 products) 

 
antibodies-online peptides for FHL5

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry Q5TD97

ProtoNet protein and cluster: Q5TD97

2 Blocks protein domains:
IPB000362 Fumarate lyase
IPB001781 Zn-binding protein


UniProtKB/Swiss-Prot: FHL5_HUMAN, Q5TD97
Similarity: Contains 4 LIM zinc-binding domains


Find genes that share domains with FHL5           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FHL5_HUMAN, Q5TD97
Function: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a
phosphorylation-independent manner

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003713transcription coactivator activity IEA--
GO:0005515protein binding IPI--
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with FHL5           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for FHL5:
 Increased G1 DNA content 

     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fhl5):
 endocrine/exocrine gland  reproductive system 

Find genes that share phenotypes with FHL5           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Fhl5tm1Saco for FHL5

   genOway: Develop your customized and physiologically relevant rodent model for FHL5

miRNA
Products:
    
miRTarBase miRNAs that target FHL5:
hsa-mir-26b-5p (MIRT029004)

Block miRNA regulation of human, mouse, rat FHL5 using miScript Target Protectors
6 qRT-PCR Assays for microRNAs that regulate FHL5:
hsa-miR-3606 hsa-miR-922 hsa-miR-921 hsa-miR-143* hsa-miR-759 hsa-miR-450b-5p
SwitchGear 3'UTR luciferase reporter plasmidFHL5 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat FHL5

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHL5


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FHL5_HUMAN, Q5TD97: Nucleus. Note=Nuclei of round and elongated spermatids
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with FHL5           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for FHL5 About    
See pathways by source

SuperPathContained pathways About
1Transcription CREM signaling in testis
Transcription CREM signaling in testis

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for FHL5
    Transcription CREM signaling in testis



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FHL5
Interactions:

    GeneGlobe Interaction Network for FHL5

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

Selected Interacting proteins for FHL5 (Q5TD971, 2, 3 ENSP000003260224) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
InteractantInteraction Details
GeneCardExternal ID(s)
COILP384322, 3, ENSP000002403164MINT-2866446 I2D: score=2 STRING: ENSP00000240316
DNAL4O960153, ENSP000002160684I2D: score=4 STRING: ENSP00000216068
CREMQ030603, ENSP000002653724I2D: score=1 STRING: ENSP00000265372
SRFP118313, ENSP000002653544I2D: score=1 STRING: ENSP00000265354
ZNF446Q9NWS93, ENSP000003365654I2D: score=1 STRING: ENSP00000336565
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

Find genes that share ontologies with FHL5           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FHL5



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FHL5 gene (2 alternative transcripts): 
NM_001170807.1  NM_020482.4  

Unigene Cluster for FHL5:

Four and a half LIM domains 5
Hs.632608  [show with all ESTs]
Unigene Representative Sequence: NM_020482
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000450218 ENST00000326771(uc003pos.2) ENST00000541107(uc003pot.2)

miRNA
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Block miRNA regulation of human, mouse, rat FHL5 using miScript Target Protectors
6 qRT-PCR Assays for microRNAs that regulate FHL5:
hsa-miR-3606 hsa-miR-922 hsa-miR-921 hsa-miR-143* hsa-miR-759 hsa-miR-450b-5p
SwitchGear 3'UTR luciferase reporter plasmidFHL5 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat FHL5
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Primer
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OriGene qPCR primer pairs and template standards for FHL5
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  QuantiTect SYBR Green Assays in human, mouse, rat FHL5
  QuantiFast Probe-based Assays in human, mouse, rat FHL5

Additional mRNA sequence: 

AF278541.1 AK057611.1 AK058175.1 AK223539.1 AK314608.1 BC021723.2 BC029490.1 

5 DOTS entries:

DT.205872  DT.100747234  DT.92417613  DT.95271833  DT.92014738 

Selected AceView cDNA sequences (see all 51):

AI784680 N92352 CD171872 BP369300 AK058175 BP370509 AI823512 BP370990 
NM_020482 BF941952 AW771484 BC011015 AW304012 BP369445 AA889787 D62998 
BG771819 BM560154 AK057611 BI459075 AW629165 BI754762 BI827550 AA815365 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for FHL5 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1:                    -           -     -                                             
SP2:                    -     -     -     -                                             
SP3:                    -           -     -                                             
SP4:                                -     -                                             
SP5:                                -                                                   


ECgene alternative splicing isoforms for FHL5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FHL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAATAAAAGT
FHL5 Expression
About this image

FHL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FHL5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632608

UniProtKB/Swiss-Prot: FHL5_HUMAN, Q5TD97
Tissue specificity: Testis-specific (at protein level)

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHL5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for FHL5 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fhl51 , 5 four and a half LIM domains 51, 5 86.34(n)1
85.51(a)1
  4 (10.58 cM)5
577561  NM_021318.31  NP_067293.11 
 251999085 
chicken
(Gallus gallus)
Aves FHL51 four and a half LIM domains 5 73(n)
67.38(a)
  421803  NM_001277723.1  NP_001264652.1 
lizard
(Anolis carolinensis)
Reptilia FHL56
four and a half LIM domains 5
65(a)
1 ↔ 1
1(173710629-173743645)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.136512 Transcribed sequence with weak similarity to protein more 74.94(n)    BX736019.1 
zebrafish
(Danio rerio)
Actinopterygii fhl56
four and a half LIM domains 5
61(a)
1 ↔ 1
17(15446811-15452983) ENSDARG00000014805
worm
(Caenorhabditis elegans)
Secernentea lim-96
Protein LIM-9, isoform a
20(a)
1 → many
I(9181848-9210339) WBGene00006407


ENSEMBL Gene Tree for FHL5 (if available)
TreeFam Gene Tree for FHL5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FHL5 gene
LIMS12  PDLIM72  LIMS3L2  FHL32  LDB32  LPXN2  FHL12  ENSG000002572072  
LIMS32  TGFB1I12  PDLIM52  PXN2  FHL22  LIMS22  
4 SIMAP similar genes for FHL5 using alignment to 1 protein entry:     FHL5_HUMAN:
FHL2    AAG11    FHL3    FHL1

Find genes that share paralogs with FHL5           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FHL5 (see all 1127)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1179659871,2
C,F--97008505(+) CTTCAT/CCAAAT 2 -- us2k11Minor allele frequency- C:0.03NA 120
rs1877206371,2
--97008604(+) ATTTGC/TATACT 2 -- us2k10--------
rs1467559031,2
--97008619(+) TTAATC/TTGCCT 2 -- us2k10--------
rs1925644811,2
--97008651(+) ATAAAC/TCTAGT 2 -- us2k10--------
rs117563151,2
C,F,A,H--97008678(+) ATCTCG/ACACTT 2 -- us2k118Minor allele frequency- A:0.11NS EA NA WA 2336
rs1821610921,2
--97008720(+) TCTAAC/TTAAAT 2 -- us2k10--------
rs24997761,2
C,F,H--97008749(+) ATGCAA/GTATAT 2 -- us2k16Minor allele frequency- G:0.04NS EA WA 540
rs1869319731,2
--97008790(+) ATTAAA/TATATG 2 -- us2k10--------
rs1926824661,2
--97008831(+) GATTTG/TGTCTG 2 -- us2k10--------
rs1393484301,2
--97008900(+) TTCTGC/TTCCAG 2 -- us2k10--------

HapMap Linkage Disequilibrium report for FHL5 (97010424 - 97064512 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for FHL5:    About this table    
Variant IDTypeSubtypePubMed ID
esv267790CNV Insertion20981092
nsv507350CNV Insertion20534489
nsv886424CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FHL5
DNA2.0 Custom Variant and Variant Library Synthesis for FHL5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605126    OMIM disorders: --

1 disease for FHL5:    
About MalaCards
familial hemophagocytic lymphohistiocytosis 5


Find genes that share disorders with FHL5           About GenesLikeMe

Genetic Association Database (GAD): FHL5
Human Genome Epidemiology (HuGE) Navigator: FHL5 (7 documents)

Export disorders for FHL5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FHL5 gene, integrated from 10 sources (see all 30):
(articles sorted by number of sources associating them with FHL5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. (PubMed id 22319020)1, 4 Davies R.W....McPherson R. (Circ Cardiovasc Genet 2012)
  2. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  4. A SNP in the ACT gene associated with astrocytosis and rapid cognitive decline in AD. (PubMed id 17368652)1, 4 Belbin O....Morgan K. (Neurobiol. Aging 2008)
  5. Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males. (PubMed id 16687568)1, 4 Christensen G.L....Carrell D.T. (Mol. Hum. Reprod. 2006)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
  9. Cloning and expression of activator of CREM in testis in human testicular tissue. (PubMed id 11327716)1, 2 Palermo I.... Travali S. (Biochem. Biophys. Res. Commun. 2001)
  10. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PubMed id 23793025)1 Anttila V.... . (Nat. Genet. 2013)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9457 HGNC: 17371 AceView: FHL5 Ensembl:ENSG00000112214 euGenes: HUgn9457
ECgene: FHL5 H-InvDB: FHL5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FHL5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FHL5 gene:
Search GeneIP for patents involving FHL5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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