Aliases for FHL5 Gene
External Ids for FHL5 Gene
Previous GeneCards Identifiers for FHL5 Gene
The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]
GeneCards Summary for FHL5 Gene
FHL5 (Four And A Half LIM Domains 5) is a Protein Coding gene. Diseases associated with FHL5 include hemophagocytic lymphohistiocytosis, familial, 5. Among its related pathways are Transcription_CREM signaling in testis. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is LDB3.
UniProtKB/Swiss-Prot for FHL5 Gene
May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.