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Aliases for FHL5 Gene

Aliases for FHL5 Gene

  • Four And A Half LIM Domains 5 2 3 5
  • Activator Of CAMP-Responsive Element Modulator In Testis 3 4
  • FHL-5 3 4
  • ACT 3 4
  • Activator Of CAMP-Responsive Element Modulator (CREM) In Testis 3
  • Activator Of CREM In Testis 4
  • LIM Protein ACT 3
  • 1700027G07Rik 3
  • DJ393D12.2 3

External Ids for FHL5 Gene

Previous GeneCards Identifiers for FHL5 Gene

  • GC06P097056
  • GC06P097117
  • GC06P094444

Summaries for FHL5 Gene

Entrez Gene Summary for FHL5 Gene

  • The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]

GeneCards Summary for FHL5 Gene

FHL5 (Four And A Half LIM Domains 5) is a Protein Coding gene. Diseases associated with FHL5 include Hemophagocytic Lymphohistiocytosis, Familial, 5. Among its related pathways are Transcription_CREM signaling in testis. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for FHL5 Gene

  • May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.

Gene Wiki entry for FHL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHL5 Gene

Genomics for FHL5 Gene

Regulatory Elements for FHL5 Gene

Enhancers for FHL5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FHL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FHL5 Gene

96,562,548 bp from pter
96,618,620 bp from pter
56,073 bases
Plus strand

Genomic View for FHL5 Gene

Genes around FHL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FHL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FHL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHL5 Gene

Proteins for FHL5 Gene

  • Protein details for FHL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Four and a half LIM domains protein 5
    Protein Accession:
    Secondary Accessions:
    • B2RBD1
    • E1P526
    • Q5TD98
    • Q8WW21
    • Q9NQU2

    Protein attributes for FHL5 Gene

    284 amino acids
    Molecular mass:
    32720 Da
    Quaternary structure:
    • Interacts with CREM via the third LIM domain.

    Three dimensional structures from OCA and Proteopedia for FHL5 Gene

neXtProt entry for FHL5 Gene

Proteomics data for FHL5 Gene at MOPED

Post-translational modifications for FHL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FHL5 Gene

No data available for DME Specific Peptides for FHL5 Gene

Domains & Families for FHL5 Gene

Gene Families for FHL5 Gene

Protein Domains for FHL5 Gene

Suggested Antigen Peptide Sequences for FHL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 LIM zinc-binding domains.
  • Contains 4 LIM zinc-binding domains.
genes like me logo Genes that share domains with FHL5: view

Function for FHL5 Gene

Molecular function for FHL5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.

Gene Ontology (GO) - Molecular Function for FHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23088713
genes like me logo Genes that share ontologies with FHL5: view
genes like me logo Genes that share phenotypes with FHL5: view

Animal Models for FHL5 Gene

MGI Knock Outs for FHL5:

Animal Model Products

miRNA for FHL5 Gene

miRTarBase miRNAs that target FHL5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FHL5 Gene

Localization for FHL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FHL5 Gene

Nucleus. Note=Nuclei of round and elongated spermatids.

Subcellular locations from

Jensen Localization Image for FHL5 Gene COMPARTMENTS Subcellular localization image for FHL5 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for FHL5 Gene

Pathways & Interactions for FHL5 Gene

genes like me logo Genes that share pathways with FHL5: view

Pathways by source for FHL5 Gene

1 GeneGo (Thomson Reuters) pathway for FHL5 Gene

Gene Ontology (GO) - Biological Process for FHL5 Gene


No data available for SIGNOR curated interactions for FHL5 Gene

Drugs & Compounds for FHL5 Gene

No Compound Related Data Available

Transcripts for FHL5 Gene

Unigene Clusters for FHL5 Gene

Four and a half LIM domains 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FHL5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: -

Relevant External Links for FHL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FHL5 Gene

mRNA expression in normal human tissues for FHL5 Gene

mRNA differential expression in normal tissues according to GTEx for FHL5 Gene

This gene is overexpressed in Artery - Tibial (x19.7) and Artery - Coronary (x5.6).

Protein differential expression in normal tissues from HIPED for FHL5 Gene

This gene is overexpressed in Gallbladder (19.2), Testis (17.5), and Plasma (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FHL5 Gene

SOURCE GeneReport for Unigene cluster for FHL5 Gene Hs.632608

mRNA Expression by UniProt/SwissProt for FHL5 Gene

Tissue specificity: Testis-specific (at protein level).
genes like me logo Genes that share expression patterns with FHL5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for FHL5 Gene

Orthologs for FHL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FHL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FHL5 35
  • 90.61 (n)
  • 89.44 (a)
FHL5 36
  • 89 (a)
(Canis familiaris)
Mammalia FHL5 35
  • 90.73 (n)
  • 89.44 (a)
FHL5 36
  • 89 (a)
(Mus musculus)
Mammalia Fhl5 35
  • 86.34 (n)
  • 85.51 (a)
Fhl5 16
Fhl5 36
  • 85 (a)
(Pan troglodytes)
Mammalia FHL5 35
  • 99.18 (n)
  • 99.3 (a)
FHL5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fhl5 35
  • 86.03 (n)
  • 86.62 (a)
(Monodelphis domestica)
Mammalia FHL5 36
  • 60 (a)
(Gallus gallus)
Aves FHL5 35
  • 73 (n)
  • 67.38 (a)
FHL5 36
  • 67 (a)
(Anolis carolinensis)
Reptilia FHL5 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fhl5 35
  • 67.14 (n)
  • 61.43 (a)
Str.13651 35
(Danio rerio)
Actinopterygii fhl5 36
  • 61 (a)
(Caenorhabditis elegans)
Secernentea lim-9 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for FHL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FHL5 Gene

Gene Tree for FHL5 (if available)
Gene Tree for FHL5 (if available)

Paralogs for FHL5 Gene

(4) SIMAP similar genes for FHL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FHL5: view

Variants for FHL5 Gene

Sequence variations from dbSNP and Humsavar for FHL5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2252816 - 96,610,698(+) TCTGC(A/C/G)TGGAC reference, missense
rs35157931 - 96,603,717(-) ATACA(C/T)GATCA reference, missense
rs2273621 - 96,610,677(+) TGTCC(A/G)GAGAC reference, missense
rs9373985 - 96,615,646(+) GACAG(C/G)CAGTG reference, missense
rs1010092 -- 96,598,776(+) GAAAT(A/G)TCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FHL5 Gene

Variant ID Type Subtype PubMed ID
nsv886424 CNV Loss 21882294
nsv507350 CNV Insertion 20534489
esv267790 CNV Insertion 20981092

Variation tolerance for FHL5 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.06; 98.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FHL5 Gene

Disorders for FHL5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FHL5 Gene - From: OMIM

Disorder Aliases PubMed IDs
hemophagocytic lymphohistiocytosis, familial, 5
  • familial hemophagocytic lymphohistiocytosis 5
- elite association - COSMIC cancer census association via MalaCards
Search FHL5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FHL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FHL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FHL5 Gene

Publications for FHL5 Gene

  1. A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. (PMID: 22319020) Davies R.W. … McPherson R. (Circ Cardiovasc Genet 2012) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Association of genetic loci for migraine susceptibility in the she people of China. (PMID: 26231841) Lin Q.F. … Huang G.B. (J Headache Pain 2015) 3
  4. Gene-based pleiotropy across migraine with aura and migraine without aura patient groups. (PMID: 26660531) Zhao H. … Nyholt D.R. (Cephalalgia 2015) 3
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3

Products for FHL5 Gene

Sources for FHL5 Gene