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Aliases for FHL3 Gene

Aliases for FHL3 Gene

  • Four And A Half LIM Domains 3 2 3 5
  • Skeletal Muscle LIM-Protein 2 3 4
  • SLIM-2 3 4
  • FHL-3 3 4
  • SLIM2 3 4
  • Four And A Half LIM Domains Protein 3 3
  • LIM-Only Protein FHL3 3

External Ids for FHL3 Gene

Previous GeneCards Identifiers for FHL3 Gene

  • GC01P038251
  • GC01U900008
  • GC01M037875
  • GC01M038131
  • GC01M038235
  • GC01M038462
  • GC01M036580

Summaries for FHL3 Gene

Entrez Gene Summary for FHL3 Gene

  • The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for FHL3 Gene

FHL3 (Four And A Half LIM Domains 3) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is FHL2.

Gene Wiki entry for FHL3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHL3 Gene

Genomics for FHL3 Gene

Regulatory Elements for FHL3 Gene

Enhancers for FHL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F037992 1.7 FANTOM5 Ensembl ENCODE 49.2 +5.4 5380 15.9 HDGF ARNT CREB3L1 ARID4B ZNF2 FOS ZNF263 SP5 JUNB REST FHL3 SF3A3 CDCA8 GNL2 MYCBP SNIP1 INPP5B MEAF6 UTP11 MTF1
GH01F037988 1.2 ENCODE 33.5 +15.8 15819 2.4 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SF3A3 SNIP1 GNL2 MYCBP FTH1P1 FHL3 INPP5B DNALI1 RSPO1 RRAGC
GH01F037944 1.1 ENCODE 22.7 +59.0 59020 3.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF207 FHL3 GNL2 SF3A3 INPP5B MYCBP LOC105378651
GH01F037470 1.6 FANTOM5 ENCODE 12.7 +526.2 526243 18.3 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SSRP1 GNL2 ZC3H12A LINC01137 SNIP1 MTF1 SF3A3 FTH1P1 DNALI1 FHL3 RSPO1
GH01F037900 0.9 Ensembl ENCODE 16.8 +104.0 104047 2.0 SP1 PKNOX1 MTA2 RNF2 IKZF1 EED SPI1 RELA INPP5B FHL3 MTF1 ENSG00000230955 UTP11 RNU6-584P LOC105378651
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FHL3 on UCSC Golden Path with GeneCards custom track

Promoters for FHL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000281541 706 2201 TBP HDGF TBL1XR1 ZNF48 ZBTB40 ZNF2 EGR1 KLF7 SMARCA5 ZBTB2

Genomic Location for FHL3 Gene

Chromosome:
1
Start:
37,996,770 bp from pter
End:
38,005,606 bp from pter
Size:
8,837 bases
Orientation:
Minus strand

Genomic View for FHL3 Gene

Genes around FHL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FHL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FHL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHL3 Gene

Proteins for FHL3 Gene

  • Protein details for FHL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13643-FHL3_HUMAN
    Recommended name:
    Four and a half LIM domains protein 3
    Protein Accession:
    Q13643
    Secondary Accessions:
    • D3DPT6
    • Q6I9T0
    • Q9BVA2

    Protein attributes for FHL3 Gene

    Size:
    280 amino acids
    Molecular mass:
    31192 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FHL3 Gene

neXtProt entry for FHL3 Gene

Post-translational modifications for FHL3 Gene

  • Ubiquitination at Lys 167 and Lys 235
  • Modification sites at PhosphoSitePlus

Other Protein References for FHL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FHL3 Gene

Domains & Families for FHL3 Gene

Gene Families for FHL3 Gene

Protein Domains for FHL3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FHL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q13643

UniProtKB/Swiss-Prot:

FHL3_HUMAN :
  • Contains 4 LIM zinc-binding domains.
Domain:
  • Contains 4 LIM zinc-binding domains.
genes like me logo Genes that share domains with FHL3: view

Function for FHL3 Gene

Molecular function for FHL3 Gene

GENATLAS Biochemistry:
four and a half LIM domain protein 3,skeletal muscle specific

Gene Ontology (GO) - Molecular Function for FHL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FHL3: view
genes like me logo Genes that share phenotypes with FHL3: view

Animal Model Products

miRNA for FHL3 Gene

miRTarBase miRNAs that target FHL3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FHL3 Gene

Localization for FHL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FHL3 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for FHL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005634 nucleus IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with FHL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FHL3 Gene

Pathways & Interactions for FHL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FHL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007517 muscle organ development TAS 10049693
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with FHL3: view

No data available for Pathways by source and SIGNOR curated interactions for FHL3 Gene

Drugs & Compounds for FHL3 Gene

(1) Drugs for FHL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FHL3: view

Transcripts for FHL3 Gene

Unigene Clusters for FHL3 Gene

Four and a half LIM domains 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FHL3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1:
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6: - - - -
SP7: - - - -
SP8: - -

Relevant External Links for FHL3 Gene

GeneLoc Exon Structure for
FHL3
ECgene alternative splicing isoforms for
FHL3

Expression for FHL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FHL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FHL3 Gene

This gene is overexpressed in Muscle - Skeletal (x29.8).

Protein differential expression in normal tissues from HIPED for FHL3 Gene

This gene is overexpressed in Uterus (7.2), Breast (7.0), and Esophagus (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FHL3 Gene



Protein tissue co-expression partners for FHL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of FHL3 Gene:

FHL3

SOURCE GeneReport for Unigene cluster for FHL3 Gene:

Hs.57687

mRNA Expression by UniProt/SwissProt for FHL3 Gene:

Q13643-FHL3_HUMAN
Tissue specificity: Expressed only in skeletal muscle.
genes like me logo Genes that share expression patterns with FHL3: view

Primer Products

Orthologs for FHL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FHL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FHL3 34 35
  • 99.05 (n)
dog
(Canis familiaris)
Mammalia FHL3 34 35
  • 92.38 (n)
oppossum
(Monodelphis domestica)
Mammalia FHL3 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FHL3 34 35
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia Fhl3 34 16 35
  • 89.52 (n)
rat
(Rattus norvegicus)
Mammalia Fhl3 34
  • 89.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FHL3 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FHL3 34 35
  • 74.61 (n)
lizard
(Anolis carolinensis)
Reptilia FHL3 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fhl3 34
  • 68.96 (n)
zebrafish
(Danio rerio)
Actinopterygii fhl3a 34 35
  • 67.75 (n)
fhl3b 35
  • 62 (a)
OneToMany
wufb09g09 34
fruit fly
(Drosophila melanogaster)
Insecta Lmpt 36
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea F25H5.1a 36
  • 47 (a)
F25H5.1b 36
  • 46 (a)
pin-2 35
  • 20 (a)
OneToOne
Species where no ortholog for FHL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FHL3 Gene

ENSEMBL:
Gene Tree for FHL3 (if available)
TreeFam:
Gene Tree for FHL3 (if available)

Paralogs for FHL3 Gene

(10) SIMAP similar genes for FHL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FHL3: view

Variants for FHL3 Gene

Sequence variations from dbSNP and Humsavar for FHL3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10711855 -- 37,999,520(+) CACAG(-/C)CAAGA intron-variant, upstream-variant-2KB
rs111228218 -- 38,005,350(+) CGGGG(A/C)GCTCA intron-variant
rs111280408 -- 37,998,013(+) GGGCA(C/T)GCAGT intron-variant, reference, missense
rs111318874 -- 38,006,373(+) GGCCA(-/C)CCCCC upstream-variant-2KB
rs111421639 -- 37,996,616(+) CCCCA(A/T)GGCCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FHL3 Gene

Variant ID Type Subtype PubMed ID
nsv1075438 CNV deletion 25765185
nsv1130955 CNV deletion 24896259
nsv950632 CNV deletion 24416366

Variation tolerance for FHL3 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FHL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FHL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHL3 Gene

Disorders for FHL3 Gene

Relevant External Links for FHL3

Genetic Association Database (GAD)
FHL3
Human Genome Epidemiology (HuGE) Navigator
FHL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FHL3

No disorders were found for FHL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FHL3 Gene

Publications for FHL3 Gene

  1. The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. (PMID: 10049693) Morgan M.J. … Madgwick A.J.A. (Biochem. Biophys. Res. Commun. 1999) 3 4 22 64
  2. Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1. (PMID: 10226657) Lee S.M. … Lee C.Y. (Somat. Cell Mol. Genet. 1998) 2 3 22 64
  3. Slim defines a novel family of LIM-proteins expressed in skeletal muscle. (PMID: 8753811) Morgan M.J. … Madgwick A.J.A. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 64
  4. Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. (PMID: 19139564) Ding L. … Ye Q. (J. Clin. Invest. 2009) 3 22 64
  5. FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF- 1. (PMID: 15453830) Takahashi K. … Ra C. (Biochem. J. 2005) 3 22 64

Products for FHL3 Gene

Sources for FHL3 Gene

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