Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FHL3 Gene

protein-coding   GIFtS: 57
GCID: GC01M038462

Four And A Half LIM Domains 3

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Four And A Half LIM Domains 31 2     SLIM-22 3
SLIM22 3 5     Four And A Half LIM Domains Protein 32
Skeletal Muscle LIM-Protein 22 3     LIM-Only Protein FHL32
FHL-32 3     

External Ids:    HGNC: 37041   Entrez Gene: 22752   Ensembl: ENSG000001833867   OMIM: 6027905   UniProtKB: Q136433   

Export aliases for FHL3 gene to outside databases

Previous GC identifers: GC01P038251 GC01U900008 GC01M037925 GC01M037875 GC01M038131 GC01M038235 GC01M036580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FHL3 Gene:
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain,
which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the
cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the
high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of
MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for FHL3 Gene:
FHL3 (four and a half LIM domains 3) is a protein-coding gene. Diseases associated with FHL3 include hemophagocytic lymphohistiocytosis, familial, 3, and hemophagocytic lymphohistiocytosis. GO annotations related to this gene include actin binding. An important paralog of this gene is LIMS1.

Gene Wiki entry for FHL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FHL3 gene promoter:
         E2F-3a   E2F-4   E2F-5   STAT1   E2F-1   STAT1beta   MyoD   E2F-2   STAT1alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FHL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FHL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

FHL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FHL3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M038462:  view genomic region     (about GC identifiers)

Start:
38,462,442 bp from pter      End:
38,471,278 bp from pter
Size:
8,837 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FHL3_HUMAN, Q13643 (See protein sequence)
Recommended Name: Four and a half LIM domains protein 3  
Size: 280 amino acids; 31192 Da
3 PDB 3D structures from and Proteopedia for FHL3:
1WYH (3D)        2CUQ (3D)        2EHE (3D)    
Secondary accessions: D3DPT6 Q6I9T0 Q9BVA2

Explore the universe of human proteins at neXtProt for FHL3: NX_Q13643

Explore proteomics data for FHL3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys167, Lys235
  • Modification sites at PhosphoSitePlus

  • See FHL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230807.1  NP_004459.2  

    ENSEMBL proteins: 
     ENSP00000362107  

    FHL3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FHL3
    OriGene Protein Over-expression Lysate for FHL3
    OriGene MassSpec for FHL3
    OriGene Custom Protein Services for FHL3
    GenScript Custom Purified and Recombinant Proteins Services for FHL3
    Novus Biologicals FHL3 Proteins
    Novus Biologicals FHL3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FHL3

    FHL3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FHL3
    OriGene Custom Antibody Services for FHL3
    Novus Biologicals FHL3 Antibodies
    Abcam antibodies for FHL3
    Cloud-Clone Corp. Antibodies for FHL3
    ThermoFisher Antibodies for FHL3
    LSBio Antibodies in human, mouse, rat for FHL3

    FHL3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FHL3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FHL3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FHL3
    Cloud-Clone Corp. CLIAs for FHL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q13643

    ProtoNet protein and cluster: Q13643

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: FHL3_HUMAN, Q13643
    Similarity: Contains 4 LIM zinc-binding domains


    FHL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for FHL3:
    four and a half LIM domain protein 3,skeletal muscle specific

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    FHL3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FHL3:
     Cell cycle / mitosis defect  Decreased Tat-dependent transc  Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FHL3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FHL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FHL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FHL3

    miRNA
    Products:
        
    miRTarBase miRNAs that target FHL3:
    hsa-mir-320a (MIRT044705), hsa-mir-20a-5p (MIRT050493)

    Block miRNA regulation of human, mouse, rat FHL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FHL3 (see all 13):
    hsa-miR-3678-3p hsa-miR-4254 hsa-miR-137 hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-624* hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidFHL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FHL3
    Predesigned siRNA for gene silencing in human, mouse, rat FHL3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FHL3

    Clone
    Products:
         
    OriGene clones in human, mouse for FHL3 (see all 7)
    OriGene ORF clones in mouse, rat for FHL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FHL3 (NM_004468)
    Sino Biological Human cDNA Clone for FHL3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FHL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FHL3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FHL3
    Browse ESI BIO Cell Lines and PureStem Progenitors for FHL3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IEA--
    GO:0005634nucleus IEA--
    GO:0030018Z disc IEA--

    FHL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FHL3
    Interactions:

        GeneGlobe Interaction Network for FHL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FHL3 (Q136432, 3 ENSP000003621074) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC42EP1Q005872, 3, ENSP000002490144MINT-67339 I2D: score=5 STRING: ENSP00000249014
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67427 I2D: score=5 STRING: ENSP00000263925
    MED15Q96RN52, 3, ENSP000002632054MINT-67286 I2D: score=5 STRING: ENSP00000263205
    TRIP6Q156542, 3, ENSP000002004574MINT-67806 I2D: score=5 STRING: ENSP00000200457
    FHL2Q141922, 3, ENSP000003229094MINT-16479 MINT-16480 I2D: score=3 STRING: ENSP00000322909
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517muscle organ development TAS10049693
    GO:0030036actin cytoskeleton organization IEA--

    FHL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FHL3

    1 Novoseek inferred chemical compound relationship for FHL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 44.5 2 11135358 (1), 16982898 (1)



    FHL3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FHL3 gene (2 alternative transcripts): 
    NM_001243878.1  NM_004468.4  

    Unigene Cluster for FHL3:

    Four and a half LIM domains 3
    Hs.57687  [show with all ESTs]
    Unigene Representative Sequence: BC011697
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485803 ENST00000373016(uc001cck.3 uc001ccm.3) ENST00000475084
    ENST00000477194(uc009vvl.2) ENST00000483132

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FHL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FHL3 (see all 13):
    hsa-miR-3678-3p hsa-miR-4254 hsa-miR-137 hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-624* hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidFHL3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FHL3
    Predesigned siRNA for gene silencing in human, mouse, rat FHL3
    Clone
    Products:
         
    OriGene clones in human, mouse for FHL3 (see all 7)
    OriGene ORF clones in mouse, rat for FHL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FHL3 (NM_004468)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FHL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FHL3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FHL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FHL3
      QuantiTect SYBR Green Assays in human, mouse, rat FHL3
      QuantiFast Probe-based Assays in human, mouse, rat FHL3

    Additional mRNA sequence: 

    AF133732.1 AK290641.1 AK309179.1 BC001351.2 BC011697.2 BC014501.1 BT007052.1 CR457425.1 
    U60116.2 

    14 DOTS entries:

    DT.114324  DT.95113659  DT.102832178  DT.100701500  DT.121363370  DT.91861669  DT.95113630  DT.92432591 
    DT.95219351  DT.99931972  DT.95071993  DT.97759926  DT.97795201  DT.40113934 

    Selected AceView cDNA sequences (see all 240):

    CR616103 AJ574595 BM845115 BI822055 F25778 BE258442 F35278 CR622484 
    CR601712 F24433 C01729 BM844915 BI914364 CR619025 BI822670 CR597013 
    CR622019 CR590698 BM843181 CR625653 CR623890 BX345084 CR604590 BQ930352 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FHL3 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                                                                                                
    SP2:                          -     -     -                                                         
    SP3:                                -     -                                                         
    SP4:                          -                                                                     
    SP5:                                                                                                


    ECgene alternative splicing isoforms for FHL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FHL3 expression in normal human tissues (normalized intensities)      FHL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCAAGCCC
    FHL3 Expression
    About this image


    FHL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)
    FHL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FHL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.57687

    UniProtKB/Swiss-Prot: FHL3_HUMAN, Q13643
    Tissue specificity: Expressed only in skeletal muscle

        Custom PCR Arrays for FHL3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FHL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FHL3
    QuantiTect SYBR Green Assays in human, mouse, rat FHL3
    QuantiFast Probe-based Assays in human, mouse, rat FHL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FHL3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fhl31 , 5 four and a half LIM domains 31, 5 89.52(n)1
    97.5(a)1
      4 (57.88 cM)5
    142011  NM_010213.31  NP_034343.21 
     1247007015 
    chicken
    (Gallus gallus)
    Aves FHL31 four and a half LIM domains 3 74.61(n)
    75.81(a)
      419607  XM_004947749.1  XP_004947806.1 
    lizard
    (Anolis carolinensis)
    Reptilia FHL36
    four and a half LIM domains 3
    68(a)
    1 ↔ 1
    GL343426.1(612820-621291)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fhl31 four and a half LIM domains 3 68.96(n)
    71.38(a)
      493527  NM_001008164.1  NP_001008165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb09g092 wufb09g09 73.63(n)   336412  BC061449.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F25H5.1a3 LIM domain containing proteins (6
    domains)
    47(a)
    (best of 2)
      I(9190482-9200886)   --


    ENSEMBL Gene Tree for FHL3 (if available)
    TreeFam Gene Tree for FHL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FHL3 gene
    LIMS12  PDLIM72  LIMS3L2  FHL52  LDB32  LPXN2  FHL12  ENSG000002572072  
    LIMS32  TGFB1I12  PDLIM52  PXN2  LIMS22  FHL22  
    10 SIMAP similar genes for FHL3 using alignment to 3 protein entries:     FHL3_HUMAN (see all proteins):
    AAG11    FHL2    FHL5    FHL1    LHx4    PRICKLE2
    LDB3    LMO6    PRICKLE3    TGFB1I1

    FHL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FHL3 (see all 278)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs729237241,2
    C,F--38461994(+) CCCTTG/CCTAAT 2 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1814963911,2
    --38462077(+) GCGGGA/CTTTGG 2 -- ds50010--------
    rs1996137961,2
    C--38462168(+) CCCCC-/AAACCC 2 -- ds50010--------
    rs1860066941,2
    --38462224(+) CAGGAC/TGAGCT 2 -- ds50010--------
    rs118115421,2
    C,H--38462294(+) GGCCCA/GGCCCC 2 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1911712601,2
    --38462395(+) ACACAA/CACACA 2 -- ds50010--------
    rs1468712121,2
    --38462525(+) GAGCTA/GAAATA 2 -- ut310--------
    rs1833330761,2
    --38462753(+) CCAGAA/GTCCAG 2 -- ut310--------
    rs1862695891,2
    --38462843(+) ATTCTA/GGAGTC 2 -- ut310--------
    rs45953381,2
    C--38462877(-) AGCCTC/TCATGA 2 -- ut31 ese32Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for FHL3 (38462442 - 38471278 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FHL3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FHL3
    DNA2.0 Custom Variant and Variant Library Synthesis for FHL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602790    OMIM disorders: --

    8 diseases for FHL3:    About MalaCards
    hemophagocytic lymphohistiocytosis, familial, 3    hemophagocytic lymphohistiocytosis    human t-cell leukemia virus type 1    hypoxia
    t-cell leukemia    hiv-1    leukemia    breast cancer


    FHL3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): FHL3
    Human Genome Epidemiology (HuGE) Navigator: FHL3 (4 documents)

    Export disorders for FHL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FHL3 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with FHL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Slim defines a novel family of LIM-proteins expressed in skeletal muscle. (PubMed id 8753811)1, 2, 3 Morgan M.J. and Madgwick A.J.A. (Biochem. Biophys. Res. Commun. 1996)
    2. The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. (PubMed id 10049693)1, 2, 9 Morgan M.J. and Madgwick A.J.A. (Biochem. Biophys. Res. Commun. 1999)
    3. Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1. (PubMed id 10226657)1, 3, 9 Lee S.M....Lee C.Y. (Somat. Cell Mol. Genet. 1998)
    4. Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET). (PubMed id 11135358)1, 9 Li H.Y....Waye M.M. (J. Cell. Biochem. 2001)
    5. The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. (PubMed id 15117962)1, 9 Samson T....Wixler V. (J. Biol. Chem. 2004)
    6. FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF- 1. (PubMed id 15453830)1, 9 Takahashi K.... Ra C. (Biochem. J. 2005)
    7. LIM-only protein FHL3 interacts with CDC25B2 phosphatase. (PubMed id 12681290)1, 9 Mils V....Tsui S.K. (Exp. Cell Res. 2003)
    8. Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. (PubMed id 19139564)1, 9 Ding L....Ye Q. (J. Clin. Invest. 2009)
    9. The four and a half LIM family members are novel interactants of the human T-cell leukemia virus type 1 Tax oncoprotein. (PubMed id 23616667)1 McCabe A.8....Sheehy N. (J. Virol. 2013)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2275 HGNC: 3704 AceView: FHL3 Ensembl:ENSG00000183386 euGenes: HUgn2275
    ECgene: FHL3 H-InvDB: FHL3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FHL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FHL3 gene:
    Search GeneIP for patents involving FHL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FHL3   OriGene RNAi products in human, mouse, rat for FHL3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FHL3  
     OriGene MassSpec something-or-other for FHL3   OriGene clones in human, mouse for FHL3  
     OriGene qSTAR qPCR primer pairs in human, mouse for FHL3   OriGene Purified Protein for FHL3  
     OriGene ORF clones in mouse, rat for FHL3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FHL3   OriGene Custom Protein Services for FHL3  

     
     
     Block miRNA regulation of human, mouse, rat FHL3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FHL3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FHL3 Predesigned siRNA for gene silencing in human, mouse, rat FHL3
     QuantiFast Probe-based Assays in human, mouse, rat FHL3 QuantiTect SYBR Green Assays in human, mouse, rat FHL3
     Custom PCR Arrays for FHL3 Search Chromatin IP Primers for FHL3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FHL3  GeneGlobe Interaction Network for FHL3
     Regulatory tfbs in FHL3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FHL3 GenScript cDNA clones with any tag delivered in your preferred vector for FHL3
     GenScript Custom Assay Services for FHL3 GenScript Custom overexpressing Cell Line Services for FHL3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FHL3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FHL3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FHL3 antibodies
     FHL3 proteins
     FHL3 lysates
     Antibodies for FHL3
     See all of Abcam's Antibodies, Kits and Proteins for FHL3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FHL3
     Antibodies for FHL3
     ELISAs for FHL3
     CLIAs for FHL3



     Browse ESI BIO Cell Lines and PureStem Progenitors for FHL3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHL3
     SwitchGear 3'UTR luciferase reporter plasmids for FHL3
     Browse SwitchGear Promoter luciferase reporter plasmids for FHL3
     ThermoFisher Antibodies for FHL3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FHL3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FHL3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FHL3
     LSBio Antibodies in human, mouse, rat for FHL3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FHL3 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4