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Aliases for FHL3 Gene

Aliases for FHL3 Gene

  • Four And A Half LIM Domains 3 2 3 5
  • Skeletal Muscle LIM-Protein 2 3 4
  • SLIM-2 3 4
  • FHL-3 3 4
  • SLIM2 3 4
  • LIM-Only Protein FHL3 3

External Ids for FHL3 Gene

Previous GeneCards Identifiers for FHL3 Gene

  • GC01P038251
  • GC01U900008
  • GC01M037875
  • GC01M038131
  • GC01M038235
  • GC01M038462
  • GC01M036580

Summaries for FHL3 Gene

Entrez Gene Summary for FHL3 Gene

  • The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for FHL3 Gene

FHL3 (Four And A Half LIM Domains 3) is a Protein Coding gene. Diseases associated with FHL3 include Hemophagocytic Lymphohistiocytosis, Familial, 3. GO annotations related to this gene include actin binding. An important paralog of this gene is LDB3.

Gene Wiki entry for FHL3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHL3 Gene

Genomics for FHL3 Gene

Regulatory Elements for FHL3 Gene

Enhancers for FHL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FHL3 on UCSC Golden Path with GeneCards custom track

Promoters for FHL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FHL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FHL3 Gene

37,996,770 bp from pter
38,005,606 bp from pter
8,837 bases
Minus strand

Genomic View for FHL3 Gene

Genes around FHL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FHL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FHL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHL3 Gene

Proteins for FHL3 Gene

  • Protein details for FHL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Four and a half LIM domains protein 3
    Protein Accession:
    Secondary Accessions:
    • D3DPT6
    • Q6I9T0
    • Q9BVA2

    Protein attributes for FHL3 Gene

    280 amino acids
    Molecular mass:
    31192 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FHL3 Gene

neXtProt entry for FHL3 Gene

Proteomics data for FHL3 Gene at MOPED

Post-translational modifications for FHL3 Gene

  • Ubiquitination at Lys 167 and Lys 235
  • Modification sites at PhosphoSitePlus

Other Protein References for FHL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FHL3 Gene

Domains & Families for FHL3 Gene

Gene Families for FHL3 Gene

Protein Domains for FHL3 Gene


Suggested Antigen Peptide Sequences for FHL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 LIM zinc-binding domains.
  • Contains 4 LIM zinc-binding domains.
genes like me logo Genes that share domains with FHL3: view

Function for FHL3 Gene

Molecular function for FHL3 Gene

GENATLAS Biochemistry:
four and a half LIM domain protein 3,skeletal muscle specific

Gene Ontology (GO) - Molecular Function for FHL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16189514
genes like me logo Genes that share ontologies with FHL3: view
genes like me logo Genes that share phenotypes with FHL3: view

Animal Model Products

miRNA for FHL3 Gene

miRTarBase miRNAs that target FHL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FHL3 Gene

Localization for FHL3 Gene

Subcellular locations from

Jensen Localization Image for FHL3 Gene COMPARTMENTS Subcellular localization image for FHL3 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for FHL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
genes like me logo Genes that share ontologies with FHL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FHL3 Gene

Pathways & Interactions for FHL3 Gene

SuperPathways for FHL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FHL3 Gene


No data available for Pathways by source and SIGNOR curated interactions for FHL3 Gene

Drugs & Compounds for FHL3 Gene

(1) Drugs for FHL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FHL3: view

Transcripts for FHL3 Gene

Unigene Clusters for FHL3 Gene

Four and a half LIM domains 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FHL3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP2: - - -
SP3: - -
SP4: -
SP6: - - - -
SP7: - - - -
SP8: - -

Relevant External Links for FHL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FHL3 Gene

mRNA expression in normal human tissues for FHL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FHL3 Gene

This gene is overexpressed in Muscle - Skeletal (x29.8).

Protein differential expression in normal tissues from HIPED for FHL3 Gene

This gene is overexpressed in Uterus (7.2), Breast (7.0), and Esophagus (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FHL3 Gene

SOURCE GeneReport for Unigene cluster for FHL3 Gene Hs.57687

mRNA Expression by UniProt/SwissProt for FHL3 Gene

Tissue specificity: Expressed only in skeletal muscle.
genes like me logo Genes that share expression patterns with FHL3: view

Protein tissue co-expression partners for FHL3 Gene

Primer Products

Orthologs for FHL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FHL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FHL3 35
  • 91.67 (n)
  • 97.14 (a)
FHL3 36
  • 97 (a)
(Canis familiaris)
Mammalia FHL3 35
  • 92.38 (n)
  • 97.14 (a)
FHL3 36
  • 94 (a)
(Mus musculus)
Mammalia Fhl3 35
  • 89.52 (n)
  • 97.5 (a)
Fhl3 16
Fhl3 36
  • 94 (a)
(Pan troglodytes)
Mammalia FHL3 35
  • 99.05 (n)
  • 99.64 (a)
FHL3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fhl3 35
  • 89.52 (n)
  • 97.86 (a)
(Monodelphis domestica)
Mammalia FHL3 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia FHL3 36
  • 73 (a)
(Gallus gallus)
Aves FHL3 35
  • 74.61 (n)
  • 75.81 (a)
FHL3 36
  • 65 (a)
(Anolis carolinensis)
Reptilia FHL3 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fhl3 35
  • 68.96 (n)
  • 71.38 (a)
(Danio rerio)
Actinopterygii fhl3a 35
  • 67.75 (n)
  • 69.42 (a)
wufb09g09 35
fhl3a 36
  • 69 (a)
fhl3b 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lmpt 37
  • 50 (a)
(Caenorhabditis elegans)
Secernentea F25H5.1a 37
  • 47 (a)
F25H5.1b 37
  • 46 (a)
pin-2 36
  • 20 (a)
Species with no ortholog for FHL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FHL3 Gene

Gene Tree for FHL3 (if available)
Gene Tree for FHL3 (if available)

Paralogs for FHL3 Gene

(10) SIMAP similar genes for FHL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FHL3: view

Variants for FHL3 Gene

Sequence variations from dbSNP and Humsavar for FHL3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1129958 -- 37,997,079(-) GGACT(C/T)TGGGA utr-variant-3-prime
rs4634868 -- 37,999,643(-) TTTTT(C/T)CTGAC intron-variant
rs4570384 -- 37,998,967(-) TATGT(C/G)TTCAG intron-variant
rs4595338 -- 37,997,205(-) AGCCT(C/T)CATGA utr-variant-3-prime
rs4262508 -- 38,002,857(-) cgagg(C/G)tgccg intron-variant

Variation tolerance for FHL3 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FHL3 Gene

Disorders for FHL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FHL3 Gene - From: OMIM

Disorder Aliases PubMed IDs
hemophagocytic lymphohistiocytosis, familial, 3
  • hlh3
- elite association - COSMIC cancer census association via MalaCards
Search FHL3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FHL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FHL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FHL3 Gene

Publications for FHL3 Gene

  1. Slim defines a novel family of LIM-proteins expressed in skeletal muscle. (PMID: 8753811) Morgan M.J. … Madgwick A.J.A. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 67
  2. Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1. (PMID: 10226657) Lee S.M. … Lee C.Y. (Somat. Cell Mol. Genet. 1998) 2 3 23
  3. Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. (PMID: 19139564) Ding L. … Ye Q. (J. Clin. Invest. 2009) 3 23
  4. FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF- 1. (PMID: 15453830) Takahashi K. … Ra C. (Biochem. J. 2005) 3 23
  5. The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. (PMID: 15117962) Samson T. … Wixler V. (J. Biol. Chem. 2004) 3 23

Products for FHL3 Gene

Sources for FHL3 Gene