Aliases for FHL3 Gene
Aliases for FHL3 Gene
External Ids for FHL3 Gene
- HGNC: 3704
- Entrez Gene: 2275
- Ensembl: ENSG00000183386
- OMIM: 602790
- UniProtKB: Q13643
Previous GeneCards Identifiers for FHL3 Gene
- GC01P038251
- GC01U900008
- GC01M037875
- GC01M038131
- GC01M038235
- GC01M038462
- GC01M036580
Summaries for FHL3 Gene
-
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for FHL3 Gene
FHL3 (Four And A Half LIM Domains 3) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is FHL2.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHL3 Gene
Genomics for FHL3 Gene
Regulatory Elements for FHL3 Gene
Enhancers for FHL3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FHL3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FHL3 gene promoter:
Regulatory Element Products
Genomic Location for FHL3 Gene
- Chromosome:
- 1
- Start:
- 37,996,770 bp from pter
- End:
- 38,005,606 bp from pter
- Size:
- 8,837 bases
- Orientation:
- Minus strand
Genomic View for FHL3 Gene
Genes around FHL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.3 by Ensembl
- 1p34.3 by Entrez Gene
- 1p34.3 by HGNC
FHL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FHL3 Gene
Proteins for FHL3 Gene
-
Protein details for FHL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13643-FHL3_HUMAN
- Recommended name:
- Four and a half LIM domains protein 3
- Protein Accession:
- Q13643
- D3DPT6
- Q6I9T0
- Q9BVA2
Protein attributes for FHL3 Gene
- Size:
- 280 amino acids
- Molecular mass:
- 31192 Da
- Quaternary structure:
- No Data Available
Protein Expression for FHL3 Gene
Post-translational modifications for FHL3 Gene
Other Protein References for FHL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FHL3
- Invitrogen Antibodies for FHL3
- antibodies-online Antibodies for FHL3: See all 33
- GeneTex FHL3 antibody for FHL3
-
Santa Cruz Biotechnology (SCBT) Antibodies for FHL3
Protein Products
-
OriGene Purified Proteins for FHL3
- Search Origene for MassSpec and Protein Over-expression Lysates for FHL3
- Origene Custom Protein Services for FHL3
- ProSpec Recombinant Proteins for FHL3
- antibodies-online Proteins for FHL3: See all 10
- Search antibodies-online for peptides
- GeneTex Proteins for FHL3
Assay Products
No data available for DME Specific Peptides for FHL3 Gene
Domains & Families for FHL3 Gene
Gene Families for FHL3 Gene
Protein Domains for FHL3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FHL3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FHL3 Gene
Function for FHL3 Gene
Molecular function for FHL3 Gene
- GENATLAS Biochemistry:
- four and a half LIM domain protein 3,skeletal muscle specific
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for FHL3 Gene
- GenomeRNAi human phenotypes for FHL3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FHL3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FHL3 gene
- Search ViGene Biosciences for FHL3
CRISPR Products
-
OriGene CRISPR knockouts for FHL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FHL3
- GenScript: Design CRISPR guide RNA sequences for FHL3
miRNA for FHL3 Gene
- miRTarBase miRNAs that target FHL3
miRNA Products
- Search ViGene Biosciences for FHL3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FHL3
- Browse OriGene Inhibitory RNA Products For FHL3
-
ViGene Biosciences ready-to-package AAV shRNAs for FHL3 gene
Clone Products
- Sino Biological Human cDNA Clone for FHL3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FHL3
-
ViGene Biosciences adenoviral particle packaged cDNA for FHL3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FHL3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FHL3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FHL3 Gene
Localization for FHL3 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| cytoskeleton | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001725 | stress fiber | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005925 | focal adhesion | IDA | 21423176 |
| GO:0030018 | Z disc | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FHL3 Gene
Pathways & Interactions for FHL3 Gene
No Data Available
Interacting Proteins for FHL3 Gene
Selected Interacting proteins:
Q13643-FHL3_HUMAN
ENSP00000362107
for FHL3 Gene via
IID
UniProtKB
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007517 | muscle organ development | TAS | 10049693 |
| GO:0030036 | actin cytoskeleton organization | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FHL3 Gene
Transcripts for FHL3 Gene
mRNA/cDNA for FHL3 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (240) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FHL3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FHL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FHL3
- GenScript: Design CRISPR guide RNA sequences for FHL3
miRNA Products
- Search ViGene Biosciences for FHL3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FHL3
- Browse OriGene Inhibitory RNA Products For FHL3
-
ViGene Biosciences ready-to-package AAV shRNAs for FHL3 gene
Clone Products
- Sino Biological Human cDNA Clone for FHL3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||
| SP8: | - | - |
Expression for FHL3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Skeletal Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for FHL3 Gene
This gene is overexpressed in Muscle - Skeletal (x29.8).
This gene is overexpressed in Uterus (7.2), Breast (7.0), and Esophagus (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FHL3 Gene
NURSA nuclear receptor signaling pathways regulating expression of FHL3 Gene:
FHL3SOURCE GeneReport for Unigene cluster for FHL3 Gene:
Hs.57687mRNA Expression by UniProt/SwissProt for FHL3 Gene:
Q13643-FHL3_HUMAN
Tissue specificity:
Expressed only in skeletal muscle.
Evidence on tissue expression from TISSUES for FHL3 Gene
- Muscle(4.7)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs for FHL3
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FHL3 Gene
Orthologs for FHL3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FHL3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FHL3 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FHL3 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FHL3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fhl3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fhl3 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FHL3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FHL3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FHL3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fhl3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fhl3a 34 35 |
|
||
| fhl3b 35 |
|
OneToMany | |||
| wufb09g09 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Lmpt 36 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | F25H5.1a 36 |
|
|
|
| F25H5.1b 36 |
|
|
|||
| pin-2 35 |
|
OneToOne |
- Species where no ortholog for FHL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FHL3 Gene
Paralogs for FHL3 Gene
(10) SIMAP similar genes for FHL3 Gene using alignment to 3 proteins:
Variants for FHL3 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000272678 | -- | 38,002,008(+) | AATGG(C/T)AGCTA | intron-variant | |
| rs1000307184 | -- | 37,997,322(+) | GGGGG(A/G)GCTGA | utr-variant-3-prime | |
| rs1000402425 | -- | 37,996,698(+) | CTTCC(G/T)TCCCC | downstream-variant-500B | |
| rs1000454231 | -- | 38,001,356(+) | CTGGG(C/T)CTCTT | intron-variant | |
| rs1000600703 | -- | 37,997,197(+) | GGCTT(C/G)ACTCA | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1075438 | CNV | deletion | 25765185 |
| nsv1130955 | CNV | deletion | 24896259 |
| nsv950632 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.15;
51.60% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FHL3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FHL3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHL3 Gene
Disorders for FHL3 Gene
Relevant External Links for FHL3
No disorders were found for FHL3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FHL3 Gene
Publications for FHL3 Gene
- The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. (PMID: 10049693) Morgan M.J. … Madgwick A.J.A. (Biochem. Biophys. Res. Commun. 1999) 3 4 22 64
- Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1. (PMID: 10226657) Lee S.M. … Lee C.Y. (Somat. Cell Mol. Genet. 1998) 2 3 22 64
- Slim defines a novel family of LIM-proteins expressed in skeletal muscle. (PMID: 8753811) Morgan M.J. … Madgwick A.J.A. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 64
- Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. (PMID: 19139564) Ding L. … Ye Q. (J. Clin. Invest. 2009) 3 22 64
- FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF- 1. (PMID: 15453830) Takahashi K. … Ra C. (Biochem. J. 2005) 3 22 64
Products for FHL3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for FHL3
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- OriGene qPCR primer pairs for FHL3
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- GenScript: Next-day shipping cDNA ORF clone for FHL3 in any vector
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- GenScript: Design CRISPR guide RNA sequences for FHL3
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- CloneReady with Over 120,000 Genes
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- Sino Biological Human cDNA Clone for FHL3
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FHL3
- Novus Biologicals proteins and lysates for FHL3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for FHL3
- antibodies-online Antibodies for FHL3: See all 33
- Search antibodies-online for kits
- antibodies-online Proteins for FHL3: See all 10
- Search antibodies-online for peptides
- GeneTex FHL3 antibody for FHL3
- GeneTex Proteins for FHL3
- ViGene Biosciences adenoviral particle packaged cDNA for FHL3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FHL3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FHL3 gene
- Search ViGene Biosciences for FHL3
- Santa Cruz Biotechnology (SCBT) Antibodies for FHL3
- Search Santa Cruz Biotechnology (SCBT) for FHL3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FHL3
- Horizon Cell Lines for FHL3
- Cyagen custom Knockout/knockin (KOKI) mouse models for FHL3
- VectorBuilder custom plasmid, inducible vectors for FHL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FHL3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FHL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
- (129) MeSH
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (141) ENCODE
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- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer