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FHL2 Gene

protein-coding GIFtS: 65

GC02M105343

four and a half LIM domains 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AAG11 ^²
DRAL ^¹, ², ³, ⁵
FHL-2 ^³
SLIM3 ^¹, ², ³

Descriptions
LIM domain protein DRAL ^³
SLIM 3 ^³
Skeletal muscle LIM-protein 3 ^³
aging-associated gene 11 ^²
down-regulated in rhabdomyosarcoma LIM protein ^²
four and a half LIM domains 2 ^²
four and a half LIM-domain protein 2 ^²

External Ids
HGNC: 3703¹
Entrez Gene: 2274²
UniProtKB: Q14192³
Ensembl: ENSG00000115641⁷

Search outside databases for aliases for FHL2 gene

Previous GC identifers: GC02M103841 GC02M104429 GC02M105574 GC02M105598 GC02M105590 GC02M105435

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for FHL2:

LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.[supplied by

OMIM]

UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192

Function: May function as a molecular transmitter linking various signaling pathways to

transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may

function in cell growth

Gene Wiki entry for FHL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FHL2 gene

Entrez Gene cytogenetic band: 2q12-q14 Ensembl cytogenetic band: 2q12.2 HGNC cytogenetic band: 2q12.2

FHL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M105343: (about GC identifiers)

Start:	105,340,601 bp from pter
End:	105,421,392 bp from pter
Size:	80,792 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022171.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192 (See protein sequence)

Recommended Name: Four and a half LIM domains protein 2

Size: 279 amino acids; 32193 Da

Subunit: Interacts with ZNF638 and TTN/titin. Interacts with E4F1

Subcellular location: Cytoplasm. Nucleus

PDB structures from and Proteopedia :

1X4K (3D)

1X4L (3D)

2D8Z (3D)

Secondary accessions: Q13229 Q13644 Q9P294

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001034581.1 NP_001441.4 NP_963849.1 NP_963851.2

ENSEMBL proteins:

ENSP00000338270 ENSP00000386633 ENSP00000386665 ENSP00000386892 ENSP00000350846 ENSP00000322909

ENSP00000377020 ENSP00000344266 ENSP00000377021

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FHL2)
	Human Recombinant Proteins from Abnova (FHL2)

OriGene Purified Recombinant Human Protein: FHL2

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	9150430
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IDA	18029348
GO:0005925	focal adhesion	IDA	18029348

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Antibodies for FHL2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FHL2
	R&D Systems Antibodies for FHL2
	Antibodies from Abcam (FHL2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FHL2)
	Novus Biologicals Antibodies for FHL2

Assays for FHL2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q14192

ProtoNet protein and cluster: Q14192

1 Blocks protein family: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192

Domain: The third LIM zinc-binding mediates interaction with E4F1

Similarity: Contains 4 LIM zinc-binding domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FHL2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FHL2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001039492

Applied Biosystems Silencer® siRNAs for FHL2

Sigma-Aldrich siRNA for FHL2

Sigma-Aldrich shRNA for FHL2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FHL2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001039492
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001039492
untagged cDNA clones in CMV expression vector (see all 5): NM_001039492

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001450

UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192

Function: May function as a molecular transmitter linking various signaling pathways to

transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may

function in cell growth

Genatlas biochemistry entry for FHL2:

four and a half LIM domain protein 2,heart specific form,tissue specific coactivator of the

androgen receptor,downregulated in rhabdomyosarcoma

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fhl2):

normal

skeleton

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	NAS	15572661
GO:0008270	zinc ion binding	IEA	--
GO:0042802	identical protein binding	IPI	18255255
GO:0046872	metal ion binding	IEA	--
GO:0050681	androgen receptor binding	NAS	15572661

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for FHL2

5/66 Interacting proteins for FHL2 (Q14192^{1, 2} ENSP00000344266³) via UniProtKB, MINT, and/or STRING (see all 66 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSEN2	P49810², ENSP00000355746³	MINT-16272 MINT-16270 MINT-16271 STRING (score=.983)
AR	P10275², ENSP00000363822³	MINT-16358 MINT-16359 STRING (score=.991)
ITGA7	Q13683², ENSP00000257880³	MINT-17127 MINT-17128 STRING (score=.906)
FHL3	Q13643², ENSP00000362107³	MINT-16479 MINT-16480 STRING (score=.878)
ITGB1	P05556², ENSP00000364094³	MINT-16547 MINT-16546 STRING (score=.77)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0009725	response to hormone stimulus	IMP	17975004
GO:0030521	androgen receptor signaling pathway	NAS	15572661
GO:0045893	positive regulation of transcription, DNA-dependent	NAS	15572661

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FHL2
2 Novoseek chemical compound relationships for FHL2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	21.03	1	17093190 (1)
tyrosine	0.00	1	15161045 (1)

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1 PharmGKB drug compound relationship for FHL2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antiarrhythmics	FA	12237170

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FHL2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FHL2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001039492

Sigma-Aldrich siRNA for FHL2

Sigma-Aldrich shRNA for FHL2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001039492 NM_001450 NM_201555 NM_201557

REFSEQ mRNAs for FHL2 gene (4 alternative transcripts):

NM_001039492.2 NM_001450.3 NM_201555.1 NM_201557.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001039492 NM_001450 NM_201555 NM_201557

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001039492
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001039492
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001039492

Additional cDNA sequence:

AB158503.1 AK097756.1 AK313841.1 AY634685.1 BC012742.2 BC014397.1 BC093049.1 BT006960.1

CR457437.1 CR594847.1 CR595150.1 CR604413.1 CR605289.1 CR606106.1 CR608826.1 CR615688.1

CR615852.1 CR616017.1 CR617985.1 CR623221.1 CR624743.1 CR624937.1 CR626389.1 CR626700.1

CR936682.1 CR936799.1 DQ266432.1 DQ307067.1 L42176.1 U29332.1 U60117.1

22 DOTS entries:

DT.100827711 DT.100770543 DT.100827708 DT.100827720 DT.315605 DT.95120234 DT.100827721 DT.100771253

DT.95114047 DT.121011322 DT.100827712 DT.121011340 DT.86838184 DT.97825801 DT.97848418 DT.121011330

DT.121011374 DT.40107456 DT.40132449 DT.40132450 DT.95154699 DT.121011391

24/305 AceView cDNA sequences (see all 305 ):

CR617985 CR626700 AJ709258 NM_201556 BU624620 BI821099 AW950172 CR615852

NM_201555 BX116006 AI918076 BX446510 BQ671167 CR615688 AW069447 BF221639

L42176 AI620458 NM_001450 CR606106 AI873832 BQ691655 AI357956 BM739390

highest scoring ESTs for FHL2:

U29332 AA249230 BI829702 BI836901 CF552311 N56433 N88051 R57165 AA083419 AA092085

Unigene Cluster for FHL2:

Four and a half LIM domains 2

Hs.443687 [show with all ESTs]

Unigene Representative Sequence: CR936799

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for FHL2 (see all 13 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c	·	11d
SP1:																			-				-						-
SP2:																			-				-		-				-
SP3:																	-		-				-		-				-
SP4:																	-		-		-		-		-				-
SP5:																			-				-		-				-		-		-

About this scheme

ECgene alternative splicing isoforms for FHL2

9 Ensembl transcripts including schematic representations:

ENST00000336660 ENST00000408995 ENST00000409807 ENST00000409177 ENST00000358129 ENST00000322142

ENST00000393352 ENST00000344213 ENST00000393353

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FHL2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FHL2

¹ / ² / ³

3 probe-sets matching FHL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38422_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U29332	1.00	1.00	1.00	1
202949_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001450	0.60	1.00	0.82	1
202949_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FHL2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGTGCGTTC

SOURCE GeneReport for Unigene cluster: Hs.443687
Expression variation in blood from EXPOLDB for FHL2
UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192
Tissue specificity: Expressed in skeletal muscle and heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FHL2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FHL2¹	--	four and a half LIM domains 2	90.32(n) 92.83(a)	474544 XM_531773.2 XP_531773.2
chimpanzee (Pan troglodytes)	FHL2¹	--	four and a half LIM domains 2	82.16(n) 75.46(a)	459469 XM_530486.2 XP_530486.2
cow (Bos taurus)	FHL2¹	--	four and a half LIM domains 2	86.62(n) 90.68(a)	510008 NM_001046046.1 NP_001039511.1
rat (Rattus norvegicus)	Fhl2¹	--	four and a half LIM domains 2	87.81(n) 91.4(a)	63839 NM_031677.1 NP_113865.1
mouse (Mus musculus)	Fhl2^{1, 5}	1⁵	four and a half LIM domains 2^{1, 5}	87.22(n)¹ 92.11(a)¹	14200¹ NM_010212.3¹ NP_034342.1¹ AF055889⁵ AF114381⁵ (see all 16)

About this table Species with no ortholog for FHL2

ENSEMBL Gene Tree for FHL2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for FHL2 gene

FHL5² FHL1² FHL3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/477 NCBI SNPs in FHL2 are shown (see all 477 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 180)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4851766^1,2	A,C,F,H	105383122(+)	`CTGGGG/ATGTGG`	4	--	int¹ ng3¹		4		EU EA WA	418
	rs7562577^1,2	A,C,F,H	105422640(+)	`CATATT/AATTAT`	1	--	ng3¹		4		EU EA WA	388
	rs9789508^1,2	A,C,F	105382727(+)	`AACCGG/ATCCAC`	4	--	int¹ ng3¹		4		NA EA	362
	rs17030907^1,2	C,F,H	105423189(+)	`GTTTCC/TGAGAC`	1	--	ng3¹		8		NA EA EU WA	590
	rs17651437^1,2	C,F,H	105422116(+)	`GATTCT/CTCCTT`	1	--	ng3¹		11		NA EU EA WA	980
	rs11691434^1,2	C,F,H	105422103(+)	`ACCAAC/TAGCTC`	1	--	ng3¹		8		EU EA WA	840
	rs2278500^1,2	C,F	105343978(+)	`AGGGCG/AAGTTT`	4	--	ut3¹ ese³		1		EA	748
	rs4851767^1,2	A,C	105383353(+)	`TCAAGA/GCAGGC`	4	--	ng3¹ int¹		0	--	--	--	--
--	rs11695005^1,2	C	105383862(+)	`AACAAC/TGATGC`	4	--	int¹ ng3¹		0	--	--	--	--
--	rs1850667^1,2	C	105422895(+)	`ggttgC/Tggtga`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for FHL2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602633

7 Novoseek disease relationships for FHL2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
familial hemophagocytic lymphohistiocytosis	89.24	3	15632205 (1), 16778144 (1), 16365863 (1)
prostate cancer	16.68	9	15948728 (2), 17975004 (2), 17145880 (2)
cancer	15.95	18	17352216 (5), 17682292 (2), 10649446 (2), 19015043 (1) (see all 7)
tumors	14.45	11	16378916 (6), 10873680 (1), 15161045 (1), 18252802 (1) (see all 5)
osteosarcoma	13.17	1	16311053 (1)
melanoma	0.00	2	14583455 (2)
breast cancer	0.00	15	17682292 (6), 16378916 (5), 14550570 (1)

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1 PharmGKB disease relationship for FHL2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Long QT Syndrome	FA	12237170

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/97 PubMed articles for FHL2 gene (see all 97 ):

Slim defines a novel family of LIM-proteins expressed in skeletal muscle. (PubMed id 8753811)^{1, 2, 3, 4} Morgan M.J. and Madgwick A.J.A. (1996)
Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein. (PubMed id 11001931)^{1, 3, 4} Tanahashi H. and Tabira T. (2000)
Interaction of the heart-specific LIM domain protein, FHL2, with DNA- binding nuclear protein, hNP220. (PubMed id 11813260)^{1, 3, 4} Ng E.K.O.... Fung K.P. (2002)
Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart. (PubMed id 9573400)^{1, 3, 4} Chan K.K.... Lee C.Y. (1998)
The LIM-only protein FHL2 is a negative regulator of E4F1. (PubMed id 16652157)^{3, 4} Paul C....Sardet C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. (PubMed id 12432079)^{3, 4} Lange S.... Ehler E. (2002)
Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma. (PubMed id 9150430)^{3, 4} Genini M....Schaefer B.W. (1997)
FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells. (PubMed id 17682292)^{1, 3} Martin B.T....Strebhardt K. (2007)
Expression of the transcriptional coregulator FHL2 in human breast cancer: a clinicopathologic study. (PubMed id 16378916)^{1, 3} Gabriel B....Hasenburg A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2274	HGNC: 3703	AceView: FHL2	Ensembl:ENSG00000115641	euGenes: HUgn2274
ECgene: FHL2	H-InvDB: FHL2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for FHL2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for FHL2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FHL2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FHL2		Antibodies for FHL2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FHL2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	shRNA in GFP-retroviral vector

Search Tocris compounds for FHL2

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Antibodies for FHL2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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FHL2 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for FHL2

Summaries
for FHL2

Genomic Location
for FHL2

Proteins
for FHL2

Protein Domains/
Families
for FHL2

Gene Function
for FHL2

Pathways & Interactions
for FHL2

Drugs & Compounds
for FHL2

Transcripts
for FHL2

Expression
for FHL2

Orthologs
for FHL2

Paralogs
for FHL2

SNPs/Variants
for FHL2

Disorders & Mutations
for FHL2

Medical News
for FHL2

Publications
for FHL2

Search for FHL2

Genome Databases showing FHL2

Other Databases showing FHL2

Specialized Databases showing FHL2

Licensable Technologies
for FHL2

Services
for FHL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FHL2 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor FHL2

Summariesfor FHL2

Genomic Locationfor FHL2

Proteinsfor FHL2

Protein Domains/Familiesfor FHL2

Gene Functionfor FHL2

Pathways & Interactionsfor FHL2

Drugs & Compoundsfor FHL2

Transcriptsfor FHL2

Expression for FHL2

Orthologsfor FHL2

Paralogsfor FHL2

SNPs/Variantsfor FHL2

Disorders & Mutationsfor FHL2

Medical Newsfor FHL2

Publicationsfor FHL2

Search for FHL2

Genome Databases showing FHL2

Other Databases showing FHL2

Specialized Databases showing FHL2

Licensable Technologiesfor FHL2

Servicesfor FHL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FHL2

Summaries
for FHL2

Genomic Location
for FHL2

Proteins
for FHL2

Protein Domains/
Families
for FHL2

Gene Function
for FHL2

Pathways & Interactions
for FHL2

Drugs & Compounds
for FHL2

Transcripts
for FHL2

Expression
for FHL2

Orthologs
for FHL2

Paralogs
for FHL2

SNPs/Variants
for FHL2

Disorders & Mutations
for FHL2

Medical News
for FHL2

Publications
for FHL2

Licensable Technologies
for FHL2

Services
for FHL2