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Aliases for FHL2 Gene

Aliases for FHL2 Gene

  • Four And A Half LIM Domains 2 2 3 5
  • Skeletal Muscle LIM-Protein 3 3 4
  • LIM Domain Protein DRAL 3 4
  • SLIM-3 3 4
  • FHL-2 3 4
  • SLIM3 3 4
  • DRAL 3 4
  • Down-Regulated In Rhabdomyosarcoma LIM Protein 3
  • Aging-Associated Gene 11 3
  • AAG11 3

External Ids for FHL2 Gene

Previous GeneCards Identifiers for FHL2 Gene

  • GC02M103841
  • GC02M104429
  • GC02M105574
  • GC02M105598
  • GC02M105590
  • GC02M105435
  • GC02M105974
  • GC02M099745

Summaries for FHL2 Gene

Entrez Gene Summary for FHL2 Gene

  • This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]

GeneCards Summary for FHL2 Gene

FHL2 (Four And A Half LIM Domains 2) is a Protein Coding gene. Diseases associated with FHL2 include Familial Isolated Dilated Cardiomyopathy and Rhabdomyosarcoma. Among its related pathways are RANK Signaling in Osteoclasts and Androgen receptor signaling pathway. GO annotations related to this gene include identical protein binding and transcription coactivator activity. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for FHL2 Gene

  • May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.

Gene Wiki entry for FHL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHL2 Gene

Genomics for FHL2 Gene

Regulatory Elements for FHL2 Gene

Enhancers for FHL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FHL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FHL2 Gene

Chromosome:
2
Start:
105,357,712 bp from pter
End:
105,438,773 bp from pter
Size:
81,062 bases
Orientation:
Minus strand

Genomic View for FHL2 Gene

Genes around FHL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FHL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FHL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHL2 Gene

Proteins for FHL2 Gene

  • Protein details for FHL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14192-FHL2_HUMAN
    Recommended name:
    Four and a half LIM domains protein 2
    Protein Accession:
    Q14192
    Secondary Accessions:
    • Q13229
    • Q13644
    • Q2I5I4
    • Q5TM15
    • Q9P294

    Protein attributes for FHL2 Gene

    Size:
    279 amino acids
    Molecular mass:
    32193 Da
    Quaternary structure:
    • Interacts with ZNF638 and TTN/titin. Interacts with E4F1. Interacts with GRB7. Interacts with SIRT1 and FOXO1.

    Three dimensional structures from OCA and Proteopedia for FHL2 Gene

    Alternative splice isoforms for FHL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FHL2 Gene

Proteomics data for FHL2 Gene at MOPED

Post-translational modifications for FHL2 Gene

  • Ubiquitination at Lys 167
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for FHL2 Gene

Domains & Families for FHL2 Gene

Gene Families for FHL2 Gene

Protein Domains for FHL2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q14192

UniProtKB/Swiss-Prot:

FHL2_HUMAN :
  • The third LIM zinc-binding mediates interaction with E4F1.
Domain:
  • The third LIM zinc-binding mediates interaction with E4F1.
  • Contains 4 LIM zinc-binding domains.
genes like me logo Genes that share domains with FHL2: view

Function for FHL2 Gene

Molecular function for FHL2 Gene

GENATLAS Biochemistry:
four and a half LIM domain protein 2,heart specific form,tissue specific coactivator of the androgen receptor,downregulated in rhabdomyosarcoma
UniProtKB/Swiss-Prot Function:
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.

Gene Ontology (GO) - Molecular Function for FHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IPI 15692560
genes like me logo Genes that share ontologies with FHL2: view
genes like me logo Genes that share phenotypes with FHL2: view

Human Phenotype Ontology for FHL2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FHL2 Gene

MGI Knock Outs for FHL2:

Animal Model Products

miRNA for FHL2 Gene

miRTarBase miRNAs that target FHL2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FHL2 Gene

Localization for FHL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FHL2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FHL2 Gene COMPARTMENTS Subcellular localization image for FHL2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with FHL2: view

Pathways & Interactions for FHL2 Gene

genes like me logo Genes that share pathways with FHL2: view

SIGNOR curated interactions for FHL2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15692560
GO:0001649 osteoblast differentiation IEA --
GO:0030521 androgen receptor signaling pathway NAS 15572661
GO:0043066 negative regulation of apoptotic process IDA 15692560
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with FHL2: view

Drugs & Compounds for FHL2 Gene

(4) Drugs for FHL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FHL2: view

Transcripts for FHL2 Gene

Unigene Clusters for FHL2 Gene

Four and a half LIM domains 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FHL2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - -
SP10: - - - - - - -
SP11: - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - -

Relevant External Links for FHL2 Gene

GeneLoc Exon Structure for
FHL2
ECgene alternative splicing isoforms for
FHL2

Expression for FHL2 Gene

mRNA expression in normal human tissues for FHL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FHL2 Gene

This gene is overexpressed in Heart - Left Ventricle (x18.3) and Ovary (x5.9).

Protein differential expression in normal tissues from HIPED for FHL2 Gene

This gene is overexpressed in Heart (34.2), Fetal heart (11.1), and Amniocyte (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FHL2 Gene



SOURCE GeneReport for Unigene cluster for FHL2 Gene Hs.443687

mRNA Expression by UniProt/SwissProt for FHL2 Gene

Q14192-FHL2_HUMAN
Tissue specificity: Expressed in skeletal muscle and heart.
genes like me logo Genes that share expression patterns with FHL2: view

Protein tissue co-expression partners for FHL2 Gene

- Elite partner

Primer Products

Orthologs for FHL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FHL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FHL2 35
  • 86.62 (n)
  • 90.68 (a)
FHL2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FHL2 35
  • 90.32 (n)
  • 92.83 (a)
FHL2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fhl2 35
  • 87.22 (n)
  • 92.11 (a)
Fhl2 16
Fhl2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FHL2 35
  • 96.52 (n)
  • 96.03 (a)
FHL2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fhl2 35
  • 87.81 (n)
  • 91.4 (a)
oppossum
(Monodelphis domestica)
Mammalia FHL2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FHL2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves FHL2 35
  • 81.96 (n)
  • 90.32 (a)
FHL2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FHL2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fhl2 35
  • 79.21 (n)
  • 85.3 (a)
zebrafish
(Danio rerio)
Actinopterygii fhl2a 35
  • 81.12 (n)
  • 82.44 (a)
fhl2a 36
  • 82 (a)
OneToMany
fhl2b 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Lmpt 37
  • 56 (a)
Lmpt 35
  • 64.47 (n)
  • 56.41 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005400 35
  • 63.74 (n)
  • 56.78 (a)
worm
(Caenorhabditis elegans)
Secernentea F25H5.1a 37
  • 55 (a)
F25H5.1b 37
  • 54 (a)
lim-9 35
  • 57.13 (n)
  • 55.43 (a)
lim-9 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for FHL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FHL2 Gene

ENSEMBL:
Gene Tree for FHL2 (if available)
TreeFam:
Gene Tree for FHL2 (if available)

Paralogs for FHL2 Gene

genes like me logo Genes that share paralogs with FHL2: view

Variants for FHL2 Gene

Sequence variations from dbSNP and Humsavar for FHL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_067455 -
rs880427 -- 105,368,771(-) GTTTA(C/T)ACGCC intron-variant
rs1850667 -- 105,440,006(+) ggttg(C/T)ggtga upstream-variant-2KB
rs1878829 -- 105,428,579(+) GCCCG(C/T)CCATG intron-variant
rs953962 -- 105,422,784(+) ATTGA(A/G)AAAAG intron-variant

Variation tolerance for FHL2 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FHL2 Gene

Human Gene Mutation Database (HGMD)
FHL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FHL2 Gene

Disorders for FHL2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FHL2 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
familial isolated dilated cardiomyopathy
  • familial or idiopathic dilated cardiomyopathy
rhabdomyosarcoma
hemophagocytic lymphohistiocytosis
  • haemophagocytic syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FHL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FHL2

Genetic Association Database (GAD)
FHL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FHL2
genes like me logo Genes that share disorders with FHL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FHL2 Gene

Publications for FHL2 Gene

  1. Slim defines a novel family of LIM-proteins expressed in skeletal muscle. (PMID: 8753811) Morgan M.J. … Madgwick A.J.A. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23 67
  2. Four and a half LIM domain 2 alters the impact of aryl hydrocarbon receptor on androgen receptor transcriptional activity. (PMID: 19815066) Kollara A. … Brown T.J. (J. Steroid Biochem. Mol. Biol. 2010) 3 23
  3. Deficiency of the LIM-only protein FHL2 reduces intestinal tumorigenesis in Apc mutant mice. (PMID: 20442768) Labalette C. … Wei Y. (PLoS ONE 2010) 3 23
  4. Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. (PMID: 19139564) Ding L. … Ye Q. (J. Clin. Invest. 2009) 3 23
  5. The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone. (PMID: 19265191) Neuman N.A. … Hata A. (J. Biol. Chem. 2009) 3 23

Products for FHL2 Gene

Sources for FHL2 Gene

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