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FHL2 Gene

protein-coding   GIFtS: 68
GCID: GC02M105974

Four And A Half LIM Domains 2

  See FHL2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Four And A Half LIM Domains 21 2     LIM Domain Protein DRAL2 3
DRAL2 3 5     AAG112
Skeletal Muscle LIM-Protein 32 3     Aging-Associated Gene 112
FHL-22 3     Down-Regulated In Rhabdomyosarcoma LIM Protein2
SLIM-32 3     Four And A Half LIM Domains Protein 22
SLIM32 3     

External Ids:    HGNC: 37031   Entrez Gene: 22742   Ensembl: ENSG000001156417   OMIM: 6026335   UniProtKB: Q141923   

Export aliases for FHL2 gene to outside databases

Previous GC identifers: GC02M103841 GC02M104429 GC02M105574 GC02M105598 GC02M105590 GC02M105435 GC02M105343 GC02M099745


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FHL2 Gene:
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly
conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in
each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this
gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded
protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple
alternatively spliced variants, encoding the same protein, have been identified. (provided by RefSeq, Aug 2011)

GeneCards Summary for FHL2 Gene:
FHL2 (four and a half LIM domains 2) is a protein-coding gene. Diseases associated with FHL2 include rhabdomyosarcoma, and cardiomyopathy, dilated, 1w. GO annotations related to this gene include transcription coactivator activity and identical protein binding. An important paralog of this gene is LIMS1.

UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192
Function: May function as a molecular transmitter linking various signaling pathways to transcriptional
regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the
transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and
FOXO1 deacetylation

Gene Wiki entry for FHL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FHL2 gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FHL2 promoter sequence
   Search Chromatin IP Primers for FHL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FHL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.2   Ensembl cytogenetic band:  2q12.2   HGNC cytogenetic band: 2q12.2

FHL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FHL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M105974:  view genomic region     (about GC identifiers)

Start:
105,974,169 bp from pter      End:
106,055,230 bp from pter
Size:
81,062 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192 (See protein sequence)
Recommended Name: Four and a half LIM domains protein 2  
Size: 279 amino acids; 32193 Da
Subunit: Interacts with ZNF638 and TTN/titin. Interacts with E4F1. Interacts with GRB7. Interacts with SIRT1 and
FOXO1
4 PDB 3D structures from and Proteopedia for FHL2:
1X4K (3D)        1X4L (3D)        2D8Z (3D)        2MIU (3D)    
Secondary accessions: Q13229 Q13644 Q2I5I4 Q9P294

Explore the universe of human proteins at neXtProt for FHL2: NX_Q14192

Explore proteomics data for FHL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys167
  • Modification sites at PhosphoSitePlus

  • See FHL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001034581.1  NP_001441.4  NP_963849.1  NP_963851.2  

    ENSEMBL proteins: 
     ENSP00000386892   ENSP00000344266   ENSP00000377021   ENSP00000433567   ENSP00000377020  
     ENSP00000322909   ENSP00000386665   ENSP00000386633   ENSP00000414872   ENSP00000476199  
     ENSP00000397083   ENSP00000350846   ENSP00000338270  
    Reactome Protein details: Q14192

    FHL2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q14192

    ProtoNet protein and cluster: Q14192

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192
    Domain: The third LIM zinc-binding mediates interaction with E4F1
    Similarity: Contains 4 LIM zinc-binding domains


    Find genes that share domains with FHL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FHL2_HUMAN, Q14192
    Function: May function as a molecular transmitter linking various signaling pathways to transcriptional
    regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the
    transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and
    FOXO1 deacetylation

         Genatlas biochemistry entry for FHL2:
    four and a half LIM domain protein 2,heart specific form,tissue specific coactivator of the androgen
    receptor,downregulated in rhabdomyosarcoma

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS15572661
    GO:0005515protein binding IPI14550570
    GO:0008134transcription factor binding IPI15692560
    GO:0008270zinc ion binding IEA--
    GO:0042802identical protein binding IPI10906324
         
    Find genes that share ontologies with FHL2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for FHL2:
     Decreased focal adhesion (FA)   Increased cell number in G1, a  Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fhl2):
     cardiovascular system  normal  skeleton 

    Find genes that share phenotypes with FHL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fhl2tm2Wlm for FHL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FHL2
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    hsa-mir-124-3p (MIRT023214)

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    2 qRT-PCR Assays for microRNAs that regulate FHL2:
    hsa-miR-4325 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidFHL2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FHL2_HUMAN, Q14192: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005925focal adhesion IDA--
    GO:0015629actin cytoskeleton IDA--
    GO:0030018Z disc IEA--

    Find genes that share ontologies with FHL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FHL2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37
    4RANK Signaling in Osteoclasts
    RANKL/RANK Signaling Pathway0.31
    5Transcription P53 signaling pathway
    Transcription P53 signaling pathway


    Find genes that share SuperPaths with FHL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for FHL2
        Transcription P53 signaling pathway

    5 BioSystems Pathways for FHL2
        Androgen receptor signaling pathway
    Wnt Signaling Pathway NetPath
    RANKL/RANK Signaling Pathway
    Signaling events mediated by HDAC Class III
    Coregulation of Androgen receptor activity


    1 Reactome Pathway for FHL2
        PPARA activates gene expression


    1 Kegg Pathway  (Kegg details for FHL2):
        Osteoclast differentiation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FHL2
    Interactions:

        GeneGlobe Interaction Network for FHL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FHL2 (Q141921, 2, 3 ENSP000003229094) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA1P383981, 2, 3, ENSP000003502834EBI-701903,EBI-349905 MINT-7032797 MINT-7032815 MINT-7032781 MINT-7032844 MINT-7032828 I2D: score=4 STRING: ENSP00000350283
    PSEN2P498102, 3, ENSP000003557474MINT-16272 MINT-16270 MINT-16271 I2D: score=4 STRING: ENSP00000355747
    ARP102752, 3, ENSP000003638224MINT-16358 MINT-16359 I2D: score=3 STRING: ENSP00000363822
    REV1Q9UBZ92, 3, ENSP000002584284MINT-17606 MINT-17605 I2D: score=3 STRING: ENSP00000258428
    CARD8Q9Y2G22, 3, ENSP000003519014MINT-18623 MINT-18622 I2D: score=2 STRING: ENSP00000351901
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15692560
    GO:0001649osteoblast differentiation IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0009725response to hormone IMP17975004

    Find genes that share ontologies with FHL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FHL2

    4 Novoseek inferred chemical compound relationships for FHL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 39.8 9 17975004 (3), 19015043 (1), 19164447 (1), 11001931 (1)
    zinc 17.6 1 17093190 (1)
    tamoxifen 6.85 5 16378916 (3), 15666801 (1)
    tyrosine 0 1 15161045 (1)



    Find genes that share compounds with FHL2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FHL2 gene (5 alternative transcripts): 
    NM_001039492.2  NM_001450.3  NM_201555.1  NM_201557.3  NM_201556.1  

    Unigene Cluster for FHL2:

    Four and a half LIM domains 2
    Hs.443687  [show with all ESTs]
    Unigene Representative Sequence: CR936799
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409177(uc002tdb.3) ENST00000344213(uc002tcv.3 uc002tcw.3 uc002tcy.3 uc002tcz.3 uc002tda.3 uc002tde.1)
    ENST00000393353 ENST00000530340(uc002tcx.3) ENST00000393352(uc002tct.3 uc002tdd.3 uc002tdc.3)
    ENST00000322142 ENST00000409807 ENST00000408995 ENST00000452732 ENST00000607522
    ENST00000447958 ENST00000358129 ENST00000336660
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    hsa-miR-4325 hsa-miR-340
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    Additional mRNA sequence: 

    AB158503.1 AK097756.1 AK313841.1 AY634685.1 BC012742.2 BC014397.1 BC093049.1 BT006960.1 
    CR457437.1 CR936682.1 CR936799.1 DQ266432.1 DQ307067.1 JQ313902.1 L42176.1 U29332.1 
    U60117.1 

    22 DOTS entries:

    DT.100827711  DT.100770543  DT.100827720  DT.315605  DT.100827708  DT.95120234  DT.100827721  DT.95114047 
    DT.100771253  DT.121011322  DT.100827712  DT.121011340  DT.86838184  DT.97825801  DT.97848418  DT.121011330 
    DT.121011374  DT.40107456  DT.40132449  DT.40132450  DT.95154699  DT.121011391 

    Selected AceView cDNA sequences (see all 305):

    BM461447 BF221639 AA376561 CR595150 BX446510 BC014397 BI821099 U29332 
    BQ691655 BU624620 BU726612 CR626389 BF222227 BQ070653 AW069447 BG765878 
    AW513704 AJ709258 CB120986 AI357956 CR617985 BC012742 CR624937 AI129522 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FHL2 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
    SP1:                                                        -           -                 -                                                   
    SP2:                                                        -           -     -           -                                                   
    SP3:                                                  -     -           -     -           -                                                   
    SP4:                                                  -     -     -     -     -           -                                                   
    SP5:                                                        -           -     -           -     -     -                                       


    ECgene alternative splicing isoforms for FHL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FHL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTGCGTTC
    FHL2 Expression
    About this image


    FHL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
    FHL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FHL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443687

    UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192
    Tissue specificity: Expressed in skeletal muscle and heart

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FHL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FHL2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fhl21 , 5 four and a half LIM domains 21, 5 87.22(n)1
    92.11(a)1
      1 (22.33 cM)5
    142001  NM_010212.31  NP_034342.11 
     431230745 
    chicken
    (Gallus gallus)
    Aves FHL21 four and a half LIM domains 2 81.96(n)
    90.32(a)
      418726  XM_004938511.1  XP_004938568.1 
    lizard
    (Anolis carolinensis)
    Reptilia FHL26
    four and a half LIM domains 2
    90(a)
    1 ↔ 1
    3(108872874-108909824)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fhl21 four and a half LIM domains 2 79.21(n)
    85.3(a)
      100145283  NM_001126761.1  NP_001120233.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fhl2a1 four and a half LIM domains 2a 81.12(n)
    82.44(a)
      445277  NM_001003732.1  NP_001003732.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lmpt1 , 3 transcription factor3
    Limpet1
    56(a)3
    64.47(n)1
    56.41(a)1
      398891  NM_206388.31  NP_996110.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F25H5.1a3
    lim-91
    LIM domain containing proteins (6
    domains)3
    lim-91
    55(a)
    (best of 2)3
    57.13(n)1
    55.43(a)1
      I(9190482-9200886)3
    35657121  NM_001026239.41  NP_001021410.21 


    ENSEMBL Gene Tree for FHL2 (if available)
    TreeFam Gene Tree for FHL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FHL2 gene
    LIMS12  PDLIM72  LIMS3L2  FHL32  FHL52  LDB32  LPXN2  FHL12  
    ENSG000002572072  LIMS32  TGFB1I12  PDLIM52  PXN2  LIMS22  
    15 SIMAP similar genes for FHL2 using alignment to 11 protein entries:     FHL2_HUMAN (see all proteins):
    AAG11    FHL5    APOPT1    LYRM4    OK/SW-cl.41    FHL3
    ZNF254    NRAMP1    FHL1    DKFZp686P2249    PRICKLE2    PRICKLE3
    LHx4    CRIP1    AJUBA

    Find genes that share paralogs with FHL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FHL2 (see all 1714)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910426491,2
    --105629400(+) ACAGGC/TGCTCA 4 -- ds5001 int10--------
    rs1464923481,2
    --105629545(+) CCACCA/GTGCCC 4 -- ds5001 int10--------
    rs1837568661,2
    --105629850(+) AGTTCA/GTGACA 4 -- ut310--------
    rs22785001,2
    C,F--105629988(+) AGGGCG/AAGTTT 4 -- ut31 ese32Minor allele frequency- A:0.02EA 868
    rs1450707961,2
    C,F--105630202(+) ACAGTC/TGGGGC 8 N D mis11Minor allele frequency- T:0.00NA 4552
    rs111240291,2
    C,F,A,H--105630203(-) TGCCCC/TGACTG 8 P syn1 ese318Minor allele frequency- T:0.15NS EA NA WA EU 7923
    rs30875231,2
    C,F,A,H--105630218(+) ATGTCG/ATCCCT 8 /D syn1 ese319Minor allele frequency- A:0.09MN EA NS NA EU 9121
    rs1882798571,2
    C--105630297(+) ACTGCC/TGTTCC 8 Q R mis10--------
    rs1158413321,2
    C--105630343(+) TAACAC/GAGAGA 4 -- int10--------
    rs22441821,2
    C,F,O,H--105630345(+) ACAGAG/CAGAAA 4 -- int1 trp320Minor allele frequency- C:0.36EA MN NS NA WA CSA EU 4833

    HapMap Linkage Disequilibrium report for FHL2 (105974169 - 106055230 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FHL2: --
    Human Gene Mutation Database (HGMD): FHL2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FHL2
    DNA2.0 Custom Variant and Variant Library Synthesis for FHL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602633    OMIM disorders: --

    3 diseases for FHL2:    
    About MalaCards
    rhabdomyosarcoma    cardiomyopathy, dilated, 1w    hemophagocytic lymphohistiocytosis

    1 disease from the University of Copenhagen DISEASES database for FHL2:
    Hemophagocytic lymphohistiocytosis

    Find genes that share disorders with FHL2           About GenesLikeMe

    7 Novoseek inferred disease relationships for FHL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial hemophagocytic lymphohistiocytosis 89.1 3 15632205 (1), 16778144 (1), 16365863 (1)
    prostate cancer 18.7 9 15948728 (2), 17975004 (2), 17145880 (2)
    cancer 18.4 24 17352216 (5), 17682292 (2), 20428824 (2), 10649446 (2) (see all 10)
    tumors 14.3 19 16378916 (6), 20442768 (2), 20428824 (2), 10873680 (1) (see all 7)
    osteosarcoma 9.72 1 16311053 (1)
    breast cancer 5.03 15 17682292 (6), 16378916 (5), 14550570 (1)
    melanoma 0 2 14583455 (2)

    Genetic Association Database (GAD): FHL2

    Export disorders for FHL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FHL2 gene, integrated from 10 sources (see all 153):
    (articles sorted by number of sources associating them with FHL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Slim defines a novel family of LIM-proteins expressed in skeletal muscle. (PubMed id 8753811)1, 2, 3, 9 Morgan M.J. and Madgwick A.J.A. (Biochem. Biophys. Res. Commun. 1996)
    2. Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein. (PubMed id 11001931)1, 2, 9 Tanahashi H. and Tabira T. (Hum. Mol. Genet. 2000)
    3. Interaction of the heart-specific LIM domain protein, FHL2, with DNA- binding nuclear protein, hNP220. (PubMed id 11813260)1, 2, 9 Ng E.K.O.... Fung K.P. (J. Cell. Biochem. 2002)
    4. Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart. (PubMed id 9573400)1, 2, 9 Chan K.K.... Lee C.Y. (Gene 1998)
    5. The LIM-only protein FHL2 is a negative regulator of E4F1. (PubMed id 16652157)1, 2 Paul C.... Sardet C. (Oncogene 2006)
    6. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. (PubMed id 15692560)1, 2 Yang Y.... Bai W. (EMBO J. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. (PubMed id 12432079)1, 2 Lange S.... Ehler E. (J. Cell Sci. 2002)
    9. Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma. (PubMed id 9150430)1, 2 Genini M....Schaefer B.W. (DNA Cell Biol. 1997)
    10. FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells. (PubMed id 17682292)1, 9 Martin B.T....Strebhardt K. (Cell Cycle 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2274 HGNC: 3703 AceView: FHL2 Ensembl:ENSG00000115641 euGenes: HUgn2274
    ECgene: FHL2 Kegg: 2274 H-InvDB: FHL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FHL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FHL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FHL2 gene:
    Search GeneIP for patents involving FHL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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