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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FHL2 Gene

protein-coding   GIFtS: 65
GCID: GC02M105974

four and a half LIM domains 2
 Explore 21 diseases affiliated with
FHL2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FHL2    

Aliases
for FHL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Four And A Half LIM Domains 21 2     AAG112
DRAL1 2 3 5     Aging-Associated Gene 112
SLIM31 2 3     Down-Regulated In Rhabdomyosarcoma LIM Protein2
Skeletal Muscle LIM-Protein 32 3     Four And A Half LIM Domains Protein 22
FHL-22 3     Four And A Half LIM-Domain Protein 22
SLIM-32 3     Four-And-A-Half LIM Domains 22
LIM Domain Protein DRAL2 3     

External Ids:    HGNC: 37031   Entrez Gene: 22742   Ensembl: ENSG000001156417   OMIM: 6026335   UniProtKB: Q141923   

Export aliases for FHL2 gene to outside databases

Previous GC identifers: GC02M103841 GC02M104429 GC02M105574 GC02M105598 GC02M105590 GC02M105435 GC02M105343 GC02M099745


Summaries
for FHL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FHL2:
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved,
tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger.
This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated
during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link
between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the
same protein, have been identified. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192
Function: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation.
Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional
activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation

Gene Wiki entry for FHL2


Genomic Views
for FHL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FHL2 gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FHL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FHL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FHL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.2   Ensembl cytogenetic band:  2q12.2   HGNC cytogenetic band: 2q12.2

FHL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FHL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M105974:  view genomic region     (about GC identifiers)

Start:
 105,974,169 bp from pter      End:
 106,055,230 bp from pter
Size:
 81,062 bases      Orientation:
 minus strand

Proteins
for FHL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192 (See protein sequence)
Recommended Name: Four and a half LIM domains protein 2  
Size: 279 amino acids; 32193 Da
Subunit: Interacts with ZNF638 and TTN/titin. Interacts with E4F1. Interacts with GRB7. Interacts with SIRT1 and FOXO1
Subcellular location: Cytoplasm. Nucleus
3 PDB 3D structures from and Proteopedia for FHL2:
1X4K (3D)        1X4L (3D)        2D8Z (3D)    
Secondary accessions: Q13229 Q13644 Q2I5I4 Q9P294

Explore the universe of human proteins at neXtProt for FHL2: NX_Q14192

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14192

    • FHL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001034581.1  NP_001441.4  NP_963849.1  NP_963851.2  

    ENSEMBL proteins: 
     ENSP00000386892   ENSP00000344266   ENSP00000377021   ENSP00000433567   ENSP00000377020  
     ENSP00000322909   ENSP00000386665   ENSP00000386633   ENSP00000414872   ENSP00000397083  
     ENSP00000350846   ENSP00000338270  
    Reactome Protein details: Q14192
    Human Recombinant Protein Products: 
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    Novus Biologicals FHL2 Protein
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    Uscn Proteins for FHL2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005925focal adhesion IDA--
    GO:0015629actin cytoskeleton IDA--
    GO:0030018Z disc IEA--


    FHL2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FHL2

    Protein Domains /
    Families
    for FHL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FHL2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q14192

    ProtoNet protein and cluster: Q14192

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192
    Domain: The third LIM zinc-binding mediates interaction with E4F1
    Similarity: Contains 4 LIM zinc-binding domains


    Function
    for FHL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192
    Function: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation.
    Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional
    activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation

         Genatlas biochemistry entry for FHL2:
    four and a half LIM domain protein 2,heart specific form,tissue specific coactivator of the androgen
    receptor,downregulated in rhabdomyosarcoma

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FHL2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FHL2:
    hsa-miR-4325 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: FHL2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS15572661
    GO:0005515protein binding IPI19608030
    GO:0008134transcription factor binding IPI15692560
    GO:0008270zinc ion binding IEA--
    GO:0042802identical protein binding IPI18255255


    FHL2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for FHL2:
     Decreased focal adhesion (FA)   Increased cell number in G1, a  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-out Fhl2tm2Wlm for FHL2
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fhl2):
     cardiovascular system  normal  skeleton 

    FHL2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FHL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    		PPARA Activates Gene Expression0.74
    2Transcription_P53 signaling pathway
    		Transcription_P53 signaling pathway1.00
    		Transcription P53 signaling pathway0.98
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    4Expression of FHL2
    		Expression of FHL21.00
    5Androgen receptor signaling pathway
    		Androgen receptor signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FHL2
        Transcription P53 signaling pathway


    1 GeneGo (Thomson Reuters) Pathway for FHL2
        Transcription P53 signaling pathway

    5 BioSystems Pathways for FHL2 
        RANKL/RANK Signaling Pathway
    Androgen receptor signaling pathway
    Wnt Signaling Pathway NetPath
    Signaling events mediated by HDAC Class III
    Coregulation of Androgen receptor activity

    5/6        Reactome Pathways for FHL2 (see all 6)
        Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Expression of FHL2
    Metabolism
    PPARA Activates Gene Expression
    Fatty acid, triacylglycerol, and ketone body metabolism


    1         Kegg Pathway  (Kegg details for FHL2):
        Osteoclast differentiation


    FHL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FHL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/103 Interacting proteins for FHL2 (Q141921, 2, 3 ENSP000003229094) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA1P383982, 3, ENSP000003502834MINT-7032797 MINT-7032815 MINT-7032781 MINT-7032844 MINT-7032828 I2D: score=4 STRING: ENSP00000350283
    PSEN2P498102, 3, ENSP000003557474MINT-16272 MINT-16270 MINT-16271 I2D: score=4 STRING: ENSP00000355747
    ARP102752, 3, ENSP000003638224MINT-16358 MINT-16359 I2D: score=3 STRING: ENSP00000363822
    REV1Q9UBZ92, 3, ENSP000002584284MINT-17606 MINT-17605 I2D: score=3 STRING: ENSP00000258428
    CARD8Q9Y2G22, 3, ENSP000003519014MINT-18623 MINT-18622 I2D: score=2 STRING: ENSP00000351901
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15692560
    GO:0001649osteoblast differentiation IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0009725response to hormone stimulus IMP17975004


    FHL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FHL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FHL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FHL2
    4 Novoseek chemical compound relationships for FHL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 39.8 9 17975004 (3), 19015043 (1), 19164447 (1), 11001931 (1)
    zinc 17.6 1 17093190 (1)
    tamoxifen 6.85 5 16378916 (3), 15666801 (1)
    tyrosine 0 1 15161045 (1)

    Search CenterWatch for drugs/clinical trials and news about FHL2 

    Transcripts
    for FHL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FHL2 gene (5 alternative transcripts): 
    NM_001039492.2  NM_001450.3  NM_201555.1  NM_201557.3  NM_201556.1  

    Unigene Cluster for FHL2:

    Four and a half LIM domains 2
    Hs.443687  [show with all ESTs]
    Unigene Representative Sequence: CR936799
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409177(uc002tdb.3) ENST00000344213(uc002tcv.3 uc002tcw.3 uc002tcy.3 uc002tcz.3 uc002tda.3 uc002tde.1)
    ENST00000393353 ENST00000530340(uc002tcx.3) ENST00000393352(uc002tct.3 uc002tdd.3 uc002tdc.3)
    ENST00000322142 ENST00000409807 ENST00000408995 ENST00000452732 ENST00000447958
    ENST00000358129 ENST00000336660

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    Inhib. RNA
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    Additional cDNA sequence: 

    AB158503.1 AK097756.1 AK313841.1 AY634685.1 BC012742.2 BC014397.1 BC093049.1 BT006960.1 
    CR457437.1 CR936682.1 CR936799.1 DQ266432.1 DQ307067.1 JQ313902.1 L42176.1 U29332.1 
    U60117.1 

    22 DOTS entries:

    DT.100827711  DT.100770543  DT.100827720  DT.315605  DT.100827708  DT.95120234  DT.100827721  DT.95114047 
    DT.100771253  DT.121011322  DT.100827712  DT.121011340  DT.86838184  DT.97825801  DT.97848418  DT.121011330 
    DT.121011374  DT.40107456  DT.40132449  DT.40132450  DT.95154699  DT.121011391 

    24/305 AceView cDNA sequences (see all 305):

    AA308343 AI918068 CB120986 AA376561 BI821099 AK097756 NM_201556 NM_201557 
    BC014397 BM760566 CR595150 CR605289 AI918076 AI283387 BX446510 AI891006 
    CR608826 CR594847 BQ000148 NM_001450 AJ711337 BQ691655 BU506908 BX094449 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for FHL2 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
    SP1:                                                        -           -                 -                                                   
    SP2:                                                        -           -     -           -                                                   
    SP3:                                                  -     -           -     -           -                                                   
    SP4:                                                  -     -     -     -     -           -                                                   
    SP5:                                                        -           -     -           -     -     -                                       


    ECgene alternative splicing isoforms for FHL2

    Expression
    for FHL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FHL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGTGCGTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FHL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyInterstitial StromaKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FHL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FHL2

    SOURCE GeneReport for Unigene cluster: Hs.443687

    UniProtKB/Swiss-Prot: FHL2_HUMAN, Q14192
    Tissue specificity: Expressed in skeletal muscle and heart

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    In Situ
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    Orthologs
    for FHL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FHL2 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FHL21 four and a half LIM domains 2 81.96(n)
    90.32(a)    		   418726  XM_416924.3  XP_416924.2 
    lizard
    (Anolis carolinensis)    		 Reptilia FHL26
    		 --
    		 90(a)
    		 1 ↔ 1
    		 3(108893369-108905247)
    zebrafish
    (Danio rerio)    		 Actinopterygii fhl2a1 four and a half LIM domains 2a 81.12(n)
    82.44(a)    		   445277  NM_001003732.1  NP_001003732.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Lmpt3 transcription factor 56(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea F25H5.1a3 LIM domain containing proteins (6 domains) 55(a)
    (best of 2)    		   I(9190482-9200886)   --


    ENSEMBL Gene Tree for FHL2 (if available)
    TreeFam Gene Tree for FHL2 (if available) 

    Paralogs
    for FHL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FHL2 gene
    ABLIM32  LIMS12  LIMS3L2  FHL52  LDB32  LPXN2  ABLIM22  PDLIM52  
    ENSG000002572072  LIMS22  ABLIM12  PDLIM72  EPB492  FHL32  FHL12  TGFB1I12  
    LIMS32  PXN2  
    16 SIMAP similar genes for FHL2 using alignment to 10 protein entries:     FHL2_HUMAN (see all proteins):
    AAG11    LOC100506792    FHL5    APOPT1    LYRM4    OK/SW-cl.41
    FHL3    NRAMP1    FHL1    DKFZp686P2249    PRICKLE2    LHx4
    PRICKLE3    CRIP1    AJUBA    LHX3

    FHL2 for paralogs           About GeneDecksing



    Genomic Variants
    for FHL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1464 NCBI SNPs in FHL2 are shown (see all 1464)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs621520611,2
    		C,F,--99747862(+) AAGATG/TCTAGG 4 -- int14Minor allele frequency- T:0.10NA 126
    rs1154529351,2
    		C,F,--99749325(+) NNNNAC/ATAGCA 4 -- int11Minor allele frequency- A:0.03NA 120
    rs728238771,2
    		--99749632(+) TCACAA/GTCACA 4 -- int10--------
    rs758851381,2
    		C,F,--99749803(+) TGGTTA/CATGAC 4 -- int11Minor allele frequency- C:0.04WA 118
    rs170308171,2
    		C,F,H,--99751220(+) CAGCAC/GTTAGA 4 -- int18Minor allele frequency- G:0.04NA NS EA WA 678
    rs784791131,2
    		F,--99751413(+) CTGGCG/ACTGCC 4 -- int11Minor allele frequency- A:0.05WA 118
    rs758736631,2
    		--99751425(+) AGGGCG/AAGTGA 4 -- int11Minor allele frequency- A:0.01WA 118
    rs170308211,2
    		C,F,H,--99751496(+) AGCTAT/CAGCAT 4 -- int112Minor allele frequency- C:0.13NA NS EA WA 1450
    rs729450061,2
    		C,--99752097(+) ACATCC/TGTCTC 4 -- int11Minor allele frequency- T:0.50WA 2
    rs773391191,2
    		F,--99752261(+) GAACAT/CATTTA 4 -- int11Minor allele frequency- C:0.07WA 118

    HapMap Linkage Disequilibrium report for FHL2 (105974169 - 106055230 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FHL2: --
    Human Gene Mutation Database (HGMD): FHL2

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    Disorders / Diseases
    for FHL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FHL2 for disorders           About GeneDecksing

    OMIM gene information: 602633    OMIM disorders: --

    20/21 diseases for FHL2 (see all 21):    About MalaCards
    rhabdomyosarcoma    hemophagocytic lymphohistiocytosis    temporal lobe epilepsy    dilated cardiomyopathy
    epithelial ovarian cancer    ovarian cancer    myeloid leukemia    cardiomyopathy
    osteosarcoma    prostate cancer    breast cancer    liver cancer
    alzheimer's disease    colon cancer    pharyngitis    melanoma
    prostatitis    ataxia    leukemia    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for FHL2:
    Hemophagocytic lymphohistiocytosis

    7 Novoseek disease relationships for FHL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial hemophagocytic lymphohistiocytosis 89.1 3 15632205 (1), 16778144 (1), 16365863 (1)
    prostate cancer 18.7 9 15948728 (2), 17975004 (2), 17145880 (2)
    cancer 18.4 24 17352216 (5), 17682292 (2), 20428824 (2), 10649446 (2) (see all 10)
    tumors 14.3 19 16378916 (6), 20442768 (2), 20428824 (2), 10873680 (1) (see all 7)
    osteosarcoma 9.72 1 16311053 (1)
    breast cancer 5.03 15 17682292 (6), 16378916 (5), 14550570 (1)
    melanoma 0 2 14583455 (2)


    Export disorders for FHL2 gene to outside databases

    Publications
    for FHL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FHL2 gene, integrated from 9 sources (see all 140):
    (articles sorted by number of sources associating them with FHL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Slim defines a novel family of LIM-proteins expressed in skeletal muscle. (PubMed id 8753811)1, 2, 3, 9 Morgan M.J. and Madgwick A.J.A. (1996)
    2. Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein. (PubMed id 11001931)1, 2, 9 Tanahashi H. and Tabira T. (2000)
    3. Interaction of the heart-specific LIM domain protein, FHL2, with DNA- binding nuclear protein, hNP220. (PubMed id 11813260)1, 2, 9 Ng E.K.O.... Fung K.P. (2002)
    4. Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart. (PubMed id 9573400)1, 2, 9 Chan K.K.... Lee C.Y. (1998)
    5. The LIM-only protein FHL2 is a negative regulator of E4F1. (PubMed id 16652157)1, 2 Paul C.... Sardet C. (2006)
    6. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. (PubMed id 15692560)1, 2 Yang Y....Bai W. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. (PubMed id 12432079)1, 2 Lange S.... Ehler E. (2002)
    9. Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma. (PubMed id 9150430)1, 2 Genini M....Schaefer B.W. (1997)
    10. FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells. (PubMed id 17682292)1, 9 Martin B.T....Strebhardt K. (2007)

    External Searches for FHL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing FHL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2274 HGNC: 3703 AceView: FHL2 Ensembl:ENSG00000115641 euGenes: HUgn2274
    ECgene: FHL2 Kegg: 2274 H-InvDB: FHL2

    Other Databases showing FHL2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FHL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FHL2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FHL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FHL2 gene:
    Search GeneIP for patents involving FHL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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