Aliases for FHL2 Gene
Aliases for FHL2 Gene
External Ids for FHL2 Gene
- HGNC: 3703
- Entrez Gene: 2274
- Ensembl: ENSG00000115641
- OMIM: 602633
- UniProtKB: Q14192
Previous GeneCards Identifiers for FHL2 Gene
- GC02M103841
- GC02M104429
- GC02M105574
- GC02M105598
- GC02M105590
- GC02M105435
- GC02M105974
- GC02M099745
Summaries for FHL2 Gene
-
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]
GeneCards Summary for FHL2 Gene
FHL2 (Four And A Half LIM Domains 2) is a Protein Coding gene. Diseases associated with FHL2 include Familial Isolated Dilated Cardiomyopathy and Rhabdomyosarcoma. Among its related pathways are Ectoderm Differentiation and Osteoclast differentiation. GO annotations related to this gene include identical protein binding and transcription coactivator activity. An important paralog of this gene is FHL5.
UniProtKB/Swiss-Prot for FHL2 Gene
-
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHL2 Gene
Genomics for FHL2 Gene
Regulatory Elements for FHL2 Gene
Enhancers for FHL2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FHL2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FHL2 gene promoter:
Regulatory Element Products
Genomic Location for FHL2 Gene
- Chromosome:
- 2
- Start:
- 105,357,712 bp from pter
- End:
- 105,438,773 bp from pter
- Size:
- 81,062 bases
- Orientation:
- Minus strand
Genomic View for FHL2 Gene
Genes around FHL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q12.2 by Ensembl
- 2q12.2 by Entrez Gene
- 2q12.2 by HGNC
FHL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FHL2 Gene
Proteins for FHL2 Gene
-
Protein details for FHL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14192-FHL2_HUMAN
- Recommended name:
- Four and a half LIM domains protein 2
- Protein Accession:
- Q14192
- Q13229
- Q13644
- Q2I5I4
- Q5TM15
- Q9P294
Protein attributes for FHL2 Gene
- Size:
- 279 amino acids
- Molecular mass:
- 32193 Da
- Quaternary structure:
-
- Interacts with ZNF638 and TTN/titin. Interacts with E4F1. Interacts with GRB7. Interacts with SIRT1 and FOXO1.
Three dimensional structures from OCA and Proteopedia for FHL2 Gene
Protein Expression for FHL2 Gene
Post-translational modifications for FHL2 Gene
Other Protein References for FHL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FHL2
- R&D Systems Antibodies for FHL2 (FHL2)
-
Custom Antibody ServicesOriGene Antibodies for FHL2
- Novus Biologicals Antibodies for FHL2
- Invitrogen Antibodies for FHL2
- antibodies-online Antibodies for FHL2: See all 72
- GeneTex FHL2 antibody for FHL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FHL2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FHL2
- Origene Custom Protein Services for FHL2
- ProSpec Recombinant Proteins for FHL2
- antibodies-online Proteins for FHL2: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FHL2
Assay Products
No data available for DME Specific Peptides for FHL2 Gene
Domains & Families for FHL2 Gene
Gene Families for FHL2 Gene
Protein Domains for FHL2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FHL2 Gene
Graphical View of Domain Structure for InterPro Entry
Q14192- Domain:
-
- The third LIM zinc-binding mediates interaction with E4F1.
Function for FHL2 Gene
Molecular function for FHL2 Gene
- GENATLAS Biochemistry:
- four and a half LIM domain protein 2,heart specific form,tissue specific coactivator of the androgen receptor,downregulated in rhabdomyosarcoma
- UniProtKB/Swiss-Prot Function:
- May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | NAS | 15572661 |
| GO:0005515 | protein binding | IPI | 14550570 |
| GO:0008134 | transcription factor binding | IPI | 15692560 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0042802 | identical protein binding | IPI | 10906324 |
Phenotypes for FHL2 Gene
- MGI mutant phenotypes for FHL2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FHL2:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased cell number in S
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FHL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FHL2 gene
- Search ViGene Biosciences for FHL2
CRISPR Products
-
OriGene CRISPR knockouts for FHL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FHL2
- GenScript: Design CRISPR guide RNA sequences for FHL2
miRNA for FHL2 Gene
- miRTarBase miRNAs that target FHL2
-
- gga-mir-2131-5p (MIRT000619)
- hsa-mir-124-3p (MIRT023214)
- hsa-mir-4768-5p (MIRT297062)
- hsa-mir-6833-3p (MIRT297063)
- hsa-mir-5698 (MIRT476846)
- hsa-mir-493-5p (MIRT476847)
- hsa-let-7g-3p (MIRT476848)
- hsa-let-7a-2-3p (MIRT476849)
- hsa-let-7c-3p (MIRT476850)
- hsa-mir-27b-3p (MIRT476851)
- hsa-mir-27a-3p (MIRT476852)
- hsa-mir-513a-5p (MIRT476853)
- hsa-mir-7151-3p (MIRT476854)
- hsa-mir-5095 (MIRT476855)
- hsa-mir-143-5p (MIRT476856)
- hsa-mir-4687-3p (MIRT476857)
- hsa-mir-7974 (MIRT476858)
- hsa-mir-4430 (MIRT476859)
- hsa-mir-3652 (MIRT476860)
- hsa-mir-122-5p (MIRT476861)
- hsa-mir-504-3p (MIRT476862)
- hsa-mir-6499-3p (MIRT476863)
- hsa-mir-3135b (MIRT476864)
- hsa-mir-5693 (MIRT476865)
- hsa-mir-764 (MIRT476866)
- hsa-mir-552-3p (MIRT476867)
- hsa-mir-4438 (MIRT476868)
- hsa-mir-6818-3p (MIRT523685)
- hsa-mir-548s (MIRT523686)
- hsa-mir-4684-5p (MIRT523687)
- hsa-mir-593-3p (MIRT523688)
- hsa-mir-6895-3p (MIRT523689)
- hsa-mir-3926 (MIRT523690)
- hsa-mir-3190-5p (MIRT523691)
- hsa-mir-8067 (MIRT523692)
- hsa-mir-6508-5p (MIRT523693)
- hsa-mir-5699-3p (MIRT523694)
- hsa-mir-4421 (MIRT523695)
- hsa-mir-339-5p (MIRT523696)
- hsa-mir-5680 (MIRT523697)
- hsa-mir-28-3p (MIRT523698)
- hsa-mir-10b-5p (MIRT523699)
- hsa-mir-10a-5p (MIRT523700)
- hsa-mir-6732-3p (MIRT523701)
- hsa-mir-3662 (MIRT539903)
- hsa-mir-574-5p (MIRT573686)
- hsa-mir-6867-5p (MIRT573687)
- hsa-mir-4999-3p (MIRT573688)
- hsa-mir-223-5p (MIRT573689)
- hsa-mir-34c-3p (MIRT573690)
- hsa-mir-4482-5p (MIRT631219)
- hsa-mir-3130-5p (MIRT631220)
- hsa-mir-1912 (MIRT631221)
- hsa-mir-1295b-5p (MIRT631222)
- hsa-mir-4652-3p (MIRT643960)
- hsa-mir-4743-3p (MIRT643961)
- hsa-mir-6809-3p (MIRT643962)
- hsa-mir-4753-3p (MIRT643963)
- hsa-mir-6794-3p (MIRT643964)
- hsa-mir-6837-3p (MIRT643965)
- hsa-mir-6754-3p (MIRT643966)
- hsa-mir-412-3p (MIRT643967)
- hsa-mir-1236-3p (MIRT643968)
- hsa-mir-4639-3p (MIRT643969)
- hsa-mir-6515-3p (MIRT643970)
- hsa-mir-5010-3p (MIRT688252)
- hsa-mir-2113 (MIRT688253)
- hsa-mir-147a (MIRT688254)
- hsa-mir-6818-5p (MIRT688255)
- hsa-mir-4775 (MIRT716754)
miRNA Products
- Search ViGene Biosciences for FHL2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FHL2
- Browse OriGene Inhibitory RNA Products For FHL2
-
ViGene Biosciences ready-to-package AAV shRNAs for FHL2 gene
Clone Products
- Sino Biological Human cDNA Clone for FHL2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FHL2
-
ViGene Biosciences adenoviral particle packaged cDNA for FHL2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FHL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FHL2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FHL2 Gene
Localization for FHL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FHL2 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| cytoskeleton | 3 |
| extracellular | 2 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 9150430 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005925 | focal adhesion | IDA | 21423176 |
| GO:0030018 | Z disc | IEA | -- |
Pathways & Interactions for FHL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Metabolism |
.37
|
|
| 3 | Osteoclast differentiation | ||
| 4 | Transcription_P53 signaling pathway | ||
| 5 | Androgen receptor signaling pathway | ||
Pathways by source for FHL2 Gene
5 BioSystems pathways for FHL2 Gene
1 KEGG pathway for FHL2 Gene
1 GeneGo (Thomson Reuters) pathway for FHL2 Gene
Interacting Proteins for FHL2 Gene
Selected Interacting proteins:
Q14192-FHL2_HUMAN
ENSP00000322909
for FHL2 Gene via
IID
UniProtKB
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IDA | 15692560 |
| GO:0001649 | osteoblast differentiation | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IEA | -- |
Transcripts for FHL2 Gene
mRNA/cDNA for FHL2 Gene
- (305) Selected AceView cDNA sequences:
- (17) Additional mRNA sequences :
- (12) REFSEQ mRNAs :
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FHL2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FHL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FHL2
- GenScript: Design CRISPR guide RNA sequences for FHL2
miRNA Products
- Search ViGene Biosciences for FHL2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FHL2
- Browse OriGene Inhibitory RNA Products For FHL2
-
ViGene Biosciences ready-to-package AAV shRNAs for FHL2 gene
Clone Products
- Sino Biological Human cDNA Clone for FHL2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - |
Expression for FHL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Cortical Stroma Cells Interstitial Stroma
- Interstitial Stroma
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Smooth Muscle (Muscoskeletal System)
-
Gall Bladder (Hepatobiliary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for FHL2 Gene
This gene is overexpressed in Heart - Left Ventricle (x18.3) and Ovary (x5.9).
This gene is overexpressed in Heart (34.2), Fetal heart (11.1), and Amniocyte (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FHL2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FHL2 Gene:
FHL2SOURCE GeneReport for Unigene cluster for FHL2 Gene:
Hs.443687mRNA Expression by UniProt/SwissProt for FHL2 Gene:
Q14192-FHL2_HUMAN
Tissue specificity:
Expressed in skeletal muscle and heart.
Evidence on tissue expression from TISSUES for FHL2 Gene
- Heart(4.7)
- Muscle(4.7)
- Blood(4.5)
- Bone marrow(4.3)
- Thyroid gland(2.6)
- Kidney(2)
- Nervous system(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FHL2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- respiratory
- skeletal muscle
Organs:
Head and neck:
- brain
- ear
- head
Thorax:
- heart
- heart valve
- lung
Limb:
- lower limb
- upper limb
General:
- blood
- blood vessel
- coagulation system
- red blood cell
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for FHL2
Orthologs for FHL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FHL2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FHL2 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FHL2 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fhl2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fhl2 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FHL2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FHL2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FHL2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FHL2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fhl2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fhl2a 34 35 |
|
||
| fhl2b 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Lmpt 36 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005400 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | lim-9 34 35 |
|
||
| F25H5.1a 36 |
|
|
|||
| F25H5.1b 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for FHL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FHL2 Gene
Paralogs for FHL2 Gene
(15) SIMAP similar genes for FHL2 Gene using alignment to 11 proteins:
Variants for FHL2 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs138189036 | Likely benign | 105,373,683(+) | CACTG(C/T)GAGCA | intron-variant, reference, synonymous-codon, utr-variant-5-prime | |
| rs141208906 | Likely benign | 105,373,716(+) | TGCCG(A/G)TCCTT | intron-variant, reference, synonymous-codon, utr-variant-5-prime | |
| rs199943518 | Likely benign | 105,373,698(+) | AAACA(A/G)GCTTC | intron-variant, reference, synonymous-codon, utr-variant-5-prime | |
| rs397517960 | Likely benign | 105,367,609(-) | TGCTA(C/T)GAGAA | reference, synonymous-codon | |
| rs74575749 | Likely benign | 105,386,408(+) | GTTGG(A/C/T)GAACA | reference, missense, utr-variant-5-prime |
Residual Variation Intolerance Score:
35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.91;
48.82% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FHL2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FHL2 Gene
Disorders for FHL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| familial isolated dilated cardiomyopathy |
|
|
| rhabdomyosarcoma |
|
|
| hemophagocytic lymphohistiocytosis |
|
|
| cervical polyp |
|
|
| testis seminoma |
|
|
Search FHL2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FHL2
No data available for UniProtKB/Swiss-Prot and Genatlas for FHL2 Gene
Publications for FHL2 Gene
- Slim defines a novel family of LIM-proteins expressed in skeletal muscle. (PMID: 8753811) Morgan M.J. … Madgwick A.J.A. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 22 64
- Interaction of the heart-specific LIM domain protein, FHL2, with DNA- binding nuclear protein, hNP220. (PMID: 11813260) Ng E.K.O. … Fung K.P. (J. Cell. Biochem. 2002) 3 4 22 64
- Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein. (PMID: 11001931) Tanahashi H. … Tabira T. (Hum. Mol. Genet. 2000) 3 4 22 64
- Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart. (PMID: 9573400) Chan K.K. … Lee C.Y. (Gene 1998) 3 4 22 64
- Four and a half LIM domain 2 alters the impact of aryl hydrocarbon receptor on androgen receptor transcriptional activity. (PMID: 19815066) Kollara A. … Brown T.J. (J. Steroid Biochem. Mol. Biol. 2010) 3 22 64
Products for FHL2 Gene
- R&D Systems Antibodies for FHL2 (FHL2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for FHL2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for FHL2
- Origene Custom Protein Services for FHL2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FHL2
- Browse OriGene Inhibitory RNA Products For FHL2
- OriGene qPCR primer pairs for FHL2
- OriGene CRISPR knockouts for FHL2
- OriGene ORF clones in human for FHL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FHL2
- GenScript: Next-day shipping cDNA ORF clone for FHL2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FHL2
- GenScript Custom Assay Services for FHL2
- GenScript Custom overexpressing Cell Line Services for FHL2
- GenScript: Design CRISPR guide RNA sequences for FHL2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FHL2
- Sino Biological Human cDNA Clone for FHL2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FHL2
- Novus Biologicals proteins and lysates for FHL2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for FHL2
- antibodies-online Antibodies for FHL2: See all 72
- Search antibodies-online for kits
- antibodies-online Proteins for FHL2: See all 12
- Search antibodies-online for peptides
- GeneTex FHL2 antibody for FHL2
- Search GeneTex for Proteins for FHL2
- ViGene Biosciences adenoviral particle packaged cDNA for FHL2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FHL2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FHL2 gene
- Search ViGene Biosciences for FHL2
- Santa Cruz Biotechnology (SCBT) Antibodies for FHL2
- Search Santa Cruz Biotechnology (SCBT) for FHL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FHL2
- Horizon Cell Lines for FHL2
- Cyagen custom Knockout/knockin (KOKI) mouse models for FHL2
- VectorBuilder custom plasmid, inducible vectors for FHL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FHL2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FHL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer