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Aliases for FHL2 Gene

Aliases for FHL2 Gene

  • Four And A Half LIM Domains 2 2 3
  • DRAL 3 4 6
  • Skeletal Muscle LIM-Protein 3 3 4
  • LIM Domain Protein DRAL 3 4
  • SLIM-3 3 4
  • FHL-2 3 4
  • SLIM3 3 4
  • Down-Regulated In Rhabdomyosarcoma LIM Protein 3
  • Four And A Half LIM Domains Protein 2 3
  • Aging-Associated Gene 11 3
  • AAG11 3

External Ids for FHL2 Gene

Previous GeneCards Identifiers for FHL2 Gene

  • GC02M103841
  • GC02M104429
  • GC02M105574
  • GC02M105598
  • GC02M105590
  • GC02M105435
  • GC02M105974
  • GC02M099745

Summaries for FHL2 Gene

Entrez Gene Summary for FHL2 Gene

  • This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for FHL2 Gene

FHL2 (Four And A Half LIM Domains 2) is a Protein Coding gene. Diseases associated with FHL2 include rhabdomyosarcoma and hemophagocytic lymphohistiocytosis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include identical protein binding and transcription coactivator activity. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for FHL2 Gene

  • May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.

Gene Wiki entry for FHL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHL2 Gene

Genomics for FHL2 Gene

Regulatory Elements for FHL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FHL2 Gene

Start:
105,357,712 bp from pter
End:
105,438,773 bp from pter
Size:
81,062 bases
Orientation:
Minus strand

Genomic View for FHL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FHL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHL2 Gene

Proteins for FHL2 Gene

  • Protein details for FHL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14192-FHL2_HUMAN
    Recommended name:
    Four and a half LIM domains protein 2
    Protein Accession:
    Q14192
    Secondary Accessions:
    • Q13229
    • Q13644
    • Q2I5I4
    • Q5TM15
    • Q9P294

    Protein attributes for FHL2 Gene

    Size:
    279 amino acids
    Molecular mass:
    32193 Da
    Quaternary structure:
    • Interacts with ZNF638 and TTN/titin. Interacts with E4F1. Interacts with GRB7. Interacts with SIRT1 and FOXO1.

    Three dimensional structures from OCA and Proteopedia for FHL2 Gene

    Alternative splice isoforms for FHL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FHL2 Gene

Proteomics data for FHL2 Gene at MOPED

Post-translational modifications for FHL2 Gene

  • Ubiquitination at Lys167
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for FHL2 Gene

Domains for FHL2 Gene

Protein Domains for FHL2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q14192

UniProtKB/Swiss-Prot:

FHL2_HUMAN :
  • Q14192
Domain:
  • The third LIM zinc-binding mediates interaction with E4F1
  • Contains 4 LIM zinc-binding domains.
genes like me logo Genes that share domains with FHL2: view

No data available for Gene Families for FHL2 Gene

Function for FHL2 Gene

Molecular function for FHL2 Gene

GENATLAS Biochemistry: four and a half LIM domain protein 2,heart specific form,tissue specific coactivator of the androgen receptor,downregulated in rhabdomyosarcoma
UniProtKB/Swiss-Prot Function: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.

Gene Ontology (GO) - Molecular Function for FHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0005515 protein binding IPI 14550570
GO:0008134 transcription factor binding IPI 15692560
GO:0008270 zinc ion binding IEA --
GO:0042802 identical protein binding IPI 10906324
genes like me logo Genes that share ontologies with FHL2: view
genes like me logo Genes that share phenotypes with FHL2: view

Animal Models for FHL2 Gene

MGI Knock Outs for FHL2:

Animal Model Products

CRISPR Products

miRNA for FHL2 Gene

miRTarBase miRNAs that target FHL2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FHL2 Gene

Localization for FHL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FHL2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FHL2 Gene COMPARTMENTS Subcellular localization image for FHL2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for FHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005925 focal adhesion IDA --
GO:0015629 actin cytoskeleton IDA --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with FHL2: view

Pathways for FHL2 Gene

genes like me logo Genes that share pathways with FHL2: view

Gene Ontology (GO) - Biological Process for FHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15692560
GO:0001649 osteoblast differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0009725 response to hormone IMP 17975004
genes like me logo Genes that share ontologies with FHL2: view

Compounds for FHL2 Gene

(4) Novoseek inferred chemical compound relationships for FHL2 Gene

Compound -log(P) Hits PubMed IDs
testosterone 39.8 6
zinc 17.6 1
tamoxifen 6.85 4
tyrosine 0 1
genes like me logo Genes that share compounds with FHL2: view

Transcripts for FHL2 Gene

Unigene Clusters for FHL2 Gene

Four and a half LIM domains 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FHL2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FHL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FHL2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - -
SP10: - - - - - - -
SP11: - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - -

Relevant External Links for FHL2 Gene

GeneLoc Exon Structure for
FHL2
ECgene alternative splicing isoforms for
FHL2

Expression for FHL2 Gene

mRNA expression in normal human tissues for FHL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FHL2 Gene

This gene is overexpressed in Heart - Left Ventricle (18.3) and Ovary (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FHL2 Gene

SOURCE GeneReport for Unigene cluster for FHL2 Gene Hs.443687

mRNA Expression by UniProt/SwissProt for FHL2 Gene

Q14192-FHL2_HUMAN
Tissue specificity: Expressed in skeletal muscle and heart.
genes like me logo Genes that share expressions with FHL2: view

In Situ Assay Products

Orthologs for FHL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FHL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FHL2 35
  • 96.52 (n)
  • 96.03 (a)
FHL2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FHL2 35
  • 86.62 (n)
  • 90.68 (a)
FHL2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FHL2 35
  • 90.32 (n)
  • 92.83 (a)
FHL2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fhl2 35
  • 87.22 (n)
  • 92.11 (a)
Fhl2 16
Fhl2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FHL2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FHL2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fhl2 35
  • 87.81 (n)
  • 91.4 (a)
chicken
(Gallus gallus)
Aves FHL2 35
  • 81.96 (n)
  • 90.32 (a)
FHL2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FHL2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fhl2 35
  • 79.21 (n)
  • 85.3 (a)
zebrafish
(Danio rerio)
Actinopterygii fhl2a 35
  • 81.12 (n)
  • 82.44 (a)
fhl2a 36
  • 82 (a)
OneToMany
fhl2b 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005400 35
  • 63.74 (n)
  • 56.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lmpt 35
  • 64.47 (n)
  • 56.41 (a)
Lmpt 37
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea lim-9 35
  • 57.13 (n)
  • 55.43 (a)
lim-9 36
  • 23 (a)
OneToMany
F25H5.1a 37
  • 55 (a)
F25H5.1b 37
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for FHL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FHL2 Gene

ENSEMBL:
Gene Tree for FHL2 (if available)
TreeFam:
Gene Tree for FHL2 (if available)

Paralogs for FHL2 Gene

genes like me logo Genes that share paralogs with FHL2: view

Variants for FHL2 Gene

Sequence variations from dbSNP and Humsavar for FHL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs880427 -- 105,368,771(-) GTTTA(C/T)ACGCC intron-variant
rs953962 -- 105,422,784(+) ATTGA(A/G)AAAAG intron-variant
rs989332 -- 105,421,915(+) CTATT(A/G)CCCAC intron-variant
rs989333 -- 105,421,991(+) CCCTC(C/T)TGGGG intron-variant
rs989334 -- 105,422,288(+) AACCA(C/T)AACCA intron-variant

Relevant External Links for FHL2 Gene

HapMap Linkage Disequilibrium report
FHL2
Human Gene Mutation Database (HGMD)
FHL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FHL2 Gene

Disorders for FHL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for FHL2 Gene including...

Search for FHL2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FHL2 Gene

(7) Novoseek inferred disease relationships for FHL2 Gene

Disease -log(P) Hits PubMed IDs
familial hemophagocytic lymphohistiocytosis 89.1 3
prostate cancer 18.7 6
cancer 18.4 17
tumors 14.3 14
osteosarcoma 9.72 1

Relevant External Links for FHL2

Genetic Association Database (GAD)
FHL2
genes like me logo Genes that share disorders with FHL2: view

No data available for UniProtKB/Swiss-Prot for FHL2 Gene

Publications for FHL2 Gene

  1. Slim defines a novel family of LIM-proteins expressed in skeletal muscle. (PMID: 8753811) Morgan M.J. … Madgwick A.J.A. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  2. Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart. (PMID: 9573400) Chan K.K. … Lee C.Y. (Gene 1998) 3 4 23
  3. Interaction of the heart-specific LIM domain protein, FHL2, with DNA- binding nuclear protein, hNP220. (PMID: 11813260) Ng E.K.O. … Fung K.P. (J. Cell. Biochem. 2002) 3 4 23
  4. Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein. (PMID: 11001931) Tanahashi H. … Tabira T. (Hum. Mol. Genet. 2000) 3 4 23
  5. BRCA1 interacts with FHL2 and enhances FHL2 transactivation function. (PMID: 14550570) Yan J. … Ye Q. (FEBS Lett. 2003) 3 23

Products for FHL2 Gene

Sources for FHL2 Gene

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