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FHIT Gene

protein-coding GIFtS: 69

GC03M059712

fragile histidine triad gene
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AP3Aase ^¹, ², ³
Dinucleosidetriphosphatase ^³
EC 3.6.1.29 ^³
FRA3B ^¹, ², ⁵
bis(5'-adenosyl)-triphosphatase ^²
dinucleosidetriphosphatase ^²

Descriptions
AP3A hydrolase ^², ³
Diadenosine 5',5'''-P1,P3-triphosphate hydrolase ^², ³
Fragile histidine triad protein ^³
fragile histidine triad gene ^²
tumor suppressor protein ^²

External Ids
HGNC: 3701¹
Entrez Gene: 2272²
UniProtKB: P49789³
Ensembl: ENSG00000189283⁷

Search outside databases for aliases for FHIT gene

Previous GC identifers: GC03M058591 GC03M059076 GC03M059592 GC03U900473 GC03M059692

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FHIT:

This gene, a member of the histidine triad gene family, encodes a diadenosine

5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene

encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can

lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from

this gene have been found in about half of all esophageal, stomach, and colon carcinomas.

[provided by RefSeq]

UniProtKB/Swiss-Prot: FHIT_HUMAN, P49789

Function: Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues

Gene Wiki entry for FHIT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FHIT gene

Entrez Gene cytogenetic band: 3p14.2 Ensembl cytogenetic band: 3p14.2 HGNC cytogenetic band: 3p14.2

FHIT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M059712: (about GC identifiers)

Start:	59,710,076 bp from pter
End:	61,212,164 bp from pter
Size:	1,502,089 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FHIT_HUMAN, P49789 (See protein sequence)

Recommended Name: Bis(5'-adenosyl)-triphosphatase

Size: 147 amino acids; 16858 Da

Cofactor: Divalent cations. Magnesium, but manganese and to a lesser extent calcium or cobalt can

be substituted; but not zinc, cadmium or nickel

Subunit: Homodimer

Subcellular location: Cytoplasm

Mass spectrometry: Mass=16733; Method=MALDI; Range=2-147; Source=PubMed:15007172;

PDB structures from and Proteopedia :

1FHI (3D)

1FIT (3D)

2FHI (3D)

2FIT (3D)

3FIT (3D)

4FIT (3D)

5FIT (3D)

6FIT (3D)

Secondary accessions: Q6IU12

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002003.1

ENSEMBL proteins:

ENSP00000342087

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant FHIT Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FHIT)
	Human Recombinant Proteins from Abnova (FHIT)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	15007172

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Antibodies for FHIT:

	Invitrogen Antibodies for FHIT
	Millipore Mono- and Polyclonal Antibodies for the study of FHIT
	Sigma-Aldrich Antibodies for FHIT
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for FHIT
	Antibodies from Abcam (FHIT), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FHIT)
	Novus Biologicals Antibodies for FHIT

Assays for FHIT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P49789

ProtoNet protein and cluster: P49789

1 Blocks protein family: IPB001310 Histidine triad (HIT) protein

UniProtKB/Swiss-Prot: FHIT_HUMAN, P49789

Similarity: Contains 1 HIT domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FHIT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FHIT)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002012

Applied Biosystems Silencer® siRNAs for FHIT

Sigma-Aldrich siRNA and siRNA Panels for FHIT

Sigma-Aldrich shRNA for FHIT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FHIT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002012
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002012
untagged cDNA clones in CMV expression vector (see all 2): NM_002012

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002012

UniProtKB/Swiss-Prot: FHIT_HUMAN, P49789

Function: Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues

Catalytic activity: P(1)-P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP

Enzyme Number (IUBMB): EC 3.6.1.29

Genatlas biochemistry entry for FHIT:

fragile histidine triad gene member of a superfamily HIT of nucleotide binding

proteins,dinucleoside 5',5''' - P1,P3 - triphosphate Ap3A hydrolase,producing multiple transcripts

in normal cell lines,non tumor specific,telomeric to PTPRG,encompassing the t(3;8) breakpoint in

RCC1 and FRA3B,commonly but inconstantly involved in deletions in cancer cell-lines and in

lung,pancreatic (RER+),stomach,kidney,cervical carcinomas and sporadic breast cancer of poor

prognosis or in an advanced stage,maybe a tumor suppressor gene in relation to induction of

apoptosis and cell cycle alteration and by interacting with microtubules and tubulin (see TSG3C)

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fhit):

digestive/alimentary	hematopoietic system	homeostasis/metabolism	immune system	life span-post-weaning/aging
skin/coat/nails	tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0005515	protein binding	IPI	18319262
GO:0016787	hydrolase activity	IDA	8794732
GO:0030145	manganese ion binding	IEA	--
GO:0047710	bis(5'-adenosyl)-triphosphatase activity	IDA	8794732

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for FHIT (Your Favorite Gene powered by Ingenuity)

Non-Small Cell Lung Cancer Signaling
Purine Metabolism
Small Cell Lung Cancer Signaling

GeneDecks FHIT for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for FHIT

5/44 Interacting proteins for FHIT (P49789^{1, 2} ENSP00000342087³) via UniProtKB, MINT, and/or STRING (see all 44 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FDXR	P22570¹, ENSP00000293195³	EBI-741760, EBI-1751533 STRING (score=.964)
HSPD1	P10809¹	EBI-741760, EBI-352528
HSPE1	P61604¹	EBI-741760, EBI-711483
FHIT	P49789²	MINT-66194
CCND1	ENSP00000227507³	STRING (score=.957)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006260	DNA replication	IEA	--
GO:0009117	nucleotide metabolic process	TAS	8794732
GO:0045786	negative regulation of cell cycle	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FHIT
10/22 Novoseek chemical compound relationships for FHIT gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diadenosine triphosphate	91.86	37	9576908 (4), 9543008 (4), 11896678 (1), 16547961 (1) (see all 17)
nickel subsulfide	47.64	3	12678982 (2), 17044645 (1)
crcs	47.31	4	11606365 (1), 12973852 (1)
galactose-1-phosphate	29.15	5	10090754 (2), 9261067 (1), 15182206 (1)
histidine	18.64	8	8794732 (2), 9391102 (1), 10090754 (1), 17310323 (1) (see all 5)
diethyl pyrocarbonate	15.69	1	16359767 (1)
dutp	13.31	1	15633221 (1)
protoporphyrin ix	13.08	6	16990010 (2), 17310323 (2), 19286306 (2)
adp	5.90	5	10090754 (2), 11896678 (1), 10407161 (1), 10027001 (1)
nucleoside	4.04	4	12627509 (1), 9261067 (1), 10671479 (1), 18694747 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FHIT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FHIT)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002012

Sigma-Aldrich siRNA and siRNA Panels for FHIT

Sigma-Aldrich shRNA for FHIT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002012

REFSEQ mRNAs for FHIT gene:

NM_002012.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002012

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002012
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002012
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002012

Additional cDNA sequence:

AK127931.1 AK289824.1 BC032336.1 BC057223.1 DQ120721.1 U46922.1

11 DOTS entries:

DT.451640 DT.92070447 DT.97795062 DT.101957680 DT.75187299 DT.100815436 DT.120886967 DT.120887070

DT.91967025 DT.95293229 DT.97836690

13 AceView cDNA sequences:

AI275155 AW772653 AW299725 BG674126 CB996786 AL699473 BG494853 BX105615

BM007419 AI026665 U46922 NM_002012 R11128

highest scoring ESTs for FHIT:

U46922 AI741386 CA306530 AA621493 AA918722 AI026665 AI245155 AI400094 AI582390 BF170093

Unigene Cluster for FHIT:

Fragile histidine triad gene

Hs.715588 [show with all ESTs]

Unigene Representative Sequence: AK127931

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FHIT (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c
SP1:			-		-		-						-				-		-				-		-
SP2:							-		-		-		-				-		-
SP3:																	-		-
SP4:																							-		-		-
SP5:					-

About this scheme

ECgene alternative splicing isoforms for FHIT

1 Ensembl transcript including schematic representation:

ENST00000341848

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FHIT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FHIT

¹ / ² / ³

4 probe-sets matching FHIT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1971_g_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.98	U46922	1.00	0.83	0.92	1
1992_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.02	U46922	1.00	0.83	0.92	1
206492_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002012	0.60	1.00	0.82	1
206492_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FHIT for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.715588
Expression variation in blood from EXPOLDB for FHIT
UniProtKB/Swiss-Prot: FHIT_HUMAN, P49789
Tissue specificity: Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and
kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FHIT gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	FHIT¹	--	fragile histidine triad gene	98.99(n) 98.48(a)	747260 XM_001156390.1 XP_001156390.1
cow (Bos taurus)	FHIT¹	--	fragile histidine triad gene	87.07(n) 90.48(a)	692183 NM_001040646.1 NP_001035736.1
rat (Rattus norvegicus)	Fhit¹	--	fragile histidine triad gene	84.58(n) 88.44(a)	60398 NM_021774.1 NP_068542.1
mouse (Mus musculus)	Fhit^{1, 5}	14 (1.75 cM)⁵	fragile histidine triad gene^{1, 5}	87.07(n)¹ 91.16(a)¹	14198¹ NM_010210.2¹ NP_034340.1¹ AA797426⁵ AF047699⁵ (see all 15)
chicken (Gallus gallus)	FHIT¹	--	fragile histidine triad gene	76.16(n) 80.56(a)	416071 XM_414409.2 XP_414409.2

About this table Species with no ortholog for FHIT

ENSEMBL Gene Tree for FHIT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/11654 NCBI SNPs in FHIT are shown (see all 11654 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 4130)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1996958^1,2	A,C,F,H	61213594(+)	`AAAAAT/AATATA`	1	--	ng3¹		4		EU EA WA	416
	rs9866051^1,2	C,F,H	59709727(+)	`TTTGCA/GGAGTG`	1	--	ng5¹		7		EU EA WA NA	472
	rs9862543^1,2	A,C	61213799(+)	`GATTTC/TAACAC`	1	--	ng3¹		0	--	--	--	--
--	rs9880846^1,2	A	61212263(+)	`GCCTAC/GGCCGG`	1	--	ng3¹		0	--	--	--	--
	rs1385816^1,2	C,F,H,O	59883166(+)	`AGAACA/GTGGAC`	1	H/H	syn¹ ese³		22		NA EA WA EU	3350
	rs17255497^1,2	C,F,H	59972152(+)	`TGTCCG/AGCTTC`	1	A/A	syn¹ ese³		11		NA EU EA WA	982
	rs2253211^1,2	A,C,F,H,O	59824587(-)	`GAATTC/TGAGCT`	1	--	int¹		8		EU EA WA	838
	rs212034^1,2	A,C,F,H,O	59936576(-)	`CAGTTC/TGTTGC`	1	--	int¹		14		NS MN EU EA WA NA	926
	rs1569346^1,2	A,C,F,H,O	60725102(+)	`AGGATA/GCAGAA`	1	--	int¹		11		EU EA WA NA	972
	rs213386^1,2	A,C,F,H,O	60283119(+)	`TGACAT/CCCCAT`	1	--	int¹		11		NA EU EA WA	974

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HapMap Linkage Disequilibrium images for FHIT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601153

UniProtKB/Swiss-Prot: FHIT_HUMAN, P49789

A chromosomal aberration involving FHIT is observed in early onset bilateral and

multifocal clear cell renal carcinoma [MIM:144700]. Translocation t(3;8) (3p14.2)

Associated with digestive tract cancers. Numerous tumor types are found to have aberrant

forms of FHIT protein due to deletions in a coding region of chromosome 3p14.2 including the

fragile site locus FRA3B

10/95 Novoseek disease relationships for FHIT gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fragile sites chromosome	85.28	7	17044645 (1), 9196019 (1), 16864578 (1), 12678982 (1) (see all 6)
allelic loss	82.16	43	10375597 (3), 11169516 (3), 11731438 (2), 15047740 (2) (see all 28)
tumors	72.17	864	16030101 (8), 12627509 (7), 16985034 (7), 10618602 (7) (see all 99)
cancer	66.87	313	11712940 (5), 17457056 (4), 10334551 (4), 12574506 (4) (see all 99)
carcinoma squamous cell	66.45	112	15231689 (8), 15757192 (4), 12753709 (4), 9699676 (3) (see all 51)
cancer lung	65.67	192	17562266 (10), 11402444 (9), 12948402 (7), 16231322 (6) (see all 61)
renal clear cell carcinoma	65.37	16	18378390 (4), 11920739 (2), 9679951 (2), 11390984 (1) (see all 8)
cervical carcinoma	64.79	77	15573771 (8), 9354423 (6), 16078573 (4), 12893195 (4) (see all 25)
cervical cancer	64.08	106	15642192 (7), 17029211 (4), 16963412 (4), 11498789 (3) (see all 36)
microsatellite instability	64.08	12	15906520 (1), 11916557 (1), 16078573 (1), 16217683 (1) (see all 11)

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1 PharmGKB disease relationship for FHIT gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Genetic Association Database: FHIT
Human Genome Epidemiology Navigator: FHIT (10 documents)
Tumor Gene Database: FHIT

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/578 PubMed articles for FHIT gene (see all 578 ):

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. (PubMed id 8598045)^{1, 2, 3, 4} Ohta M.... Huebner K. (1996)
MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family. (PubMed id 9261067)^{1, 3, 4} Lima C.D....Hendrickson W.A. (1997)
Genetic, biochemical, and crystallographic characterization of Fhit- substrate complexes as the active signaling form of Fhit. (PubMed id 9576908)^{1, 3, 4} Pace H.C....Brenner C. (1998)
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5''-P1,P3-triphosphate hydrolase. (PubMed id 8794732)^{1, 3, 4} Barnes L.D.... Huebner K. (1996)
Fhit is a physiological target of the protein kinase Src. (PubMed id 15007172)^{1, 3, 4} Pekarsky Y.... Croce C.M. (2004)
The mechanism of action of the fragile histidine triad, Fhit: isolation of a covalent adenylyl enzyme and chemical rescue of H96G- Fhit. (PubMed id 15182206)^{1, 3, 4} Huang K.... Frey P.A. (2004)
The effect of codon 98 of the FHIT gene on cervical cancer in Korean women. (PubMed id 14675322)^{1, 3, 6} Jee S.H....Park J.S. (2003)
Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. (PubMed id 9671749)^{1, 2, 3} Pekarsky Y....Croce C.M. (1998)
Structure and expression of the human FHIT gene in normal and tumor cells. (PubMed id 9012482)^{1, 3, 4} Druck T.... Huebner K. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2272	HGNC: 3701	AceView: FHIT.1	Ensembl:ENSG00000189283	euGenes: HUgn2272
ECgene: FHIT	H-InvDB: FHIT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FHIT	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for FHIT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FHIT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FHIT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FHIT		Antibodies for FHIT
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FHIT		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FHIT)
	Antibodies (FHIT)
	Chimera RNAi (FHIT)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for FHIT

	Recombinant Proteins (FHIT)
	Antibodies (FHIT)

Search OriGene for FHIT

Search Tocris compounds for FHIT

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FHIT

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
FHIT Gene at Home site.
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FHIT Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for FHIT

Summaries
for FHIT

Genomic Location
for FHIT

Proteins
for FHIT

Protein Domains/
Families
for FHIT

Gene Function
for FHIT

Pathways & Interactions
for FHIT

Drugs & Compounds
for FHIT

Transcripts
for FHIT

Expression
for FHIT

Orthologs
for FHIT

Paralogs
for FHIT

SNPs/Variants
for FHIT

Disorders & Mutations
for FHIT

Medical News
for FHIT

Publications
for FHIT

Search for FHIT

Genome Databases showing FHIT

Other Databases showing FHIT

Specialized Databases showing FHIT

Licensable Technologies
for FHIT

Services
for FHIT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FHIT Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor FHIT

Summariesfor FHIT

Genomic Locationfor FHIT

Proteinsfor FHIT

Protein Domains/Familiesfor FHIT

Gene Functionfor FHIT

Pathways & Interactionsfor FHIT

Drugs & Compoundsfor FHIT

Transcriptsfor FHIT

Expression for FHIT

Orthologsfor FHIT

Paralogsfor FHIT

SNPs/Variantsfor FHIT

Disorders & Mutationsfor FHIT

Medical Newsfor FHIT

Publicationsfor FHIT

Search for FHIT

Genome Databases showing FHIT

Other Databases showing FHIT

Specialized Databases showing FHIT

Licensable Technologiesfor FHIT

Servicesfor FHIT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FHIT

Summaries
for FHIT

Genomic Location
for FHIT

Proteins
for FHIT

Protein Domains/
Families
for FHIT

Gene Function
for FHIT

Pathways & Interactions
for FHIT

Drugs & Compounds
for FHIT

Transcripts
for FHIT

Expression
for FHIT

Orthologs
for FHIT

Paralogs
for FHIT

SNPs/Variants
for FHIT

Disorders & Mutations
for FHIT

Medical News
for FHIT

Publications
for FHIT

Licensable Technologies
for FHIT

Services
for FHIT