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Aliases for FHDC1 Gene

Aliases for FHDC1 Gene

  • FH2 Domain Containing 1 2 3 5
  • KIAA1727 4

External Ids for FHDC1 Gene

Previous GeneCards Identifiers for FHDC1 Gene

  • GC04P154084
  • GC04P153864
  • GC04P149590
  • GC04P152936

Summaries for FHDC1 Gene

GeneCards Summary for FHDC1 Gene

FHDC1 (FH2 Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is INF2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHDC1 Gene

Genomics for FHDC1 Gene

Regulatory Elements for FHDC1 Gene

Enhancers for FHDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G152953 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.4 +45.1 45133 5.6 CTCF FOXA2 MAX RAD21 RARA TEAD3 GATA2 FOXK2 HNF4G NR2F6 FHDC1 RNF175 ARFIP1 TRIM2 PIR52121 GC04P152944
GH04G153142 1.5 Ensembl ENCODE dbSUPER 10.3 +232.4 232376 2.8 ARNT ZFP64 FEZF1 TCF12 GATA2 ZNF263 TSHZ1 REST ZNF623 ZNF518A MND1 FHDC1 RNF175 TRIM2 GC04P153071 GC04P153070
GH04G152972 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +61.8 61821 2.4 ZFHX2 JUND FOS EGR2 FHDC1 PIR52121 ENSG00000249022
GH04G153062 1.4 FANTOM5 Ensembl ENCODE 10.5 +153.9 153947 5.9 ELF3 TBP PKNOX1 FOXA2 DMAP1 RARA FOS CREM SP5 USF2 FHDC1 GC04P153072 ENSG00000249022
GH04G153079 0.7 FANTOM5 19.1 +168.6 168562 0.4 TCF12 PKNOX1 ATF3 NR4A1 TAL1 CEBPB TRIM24 CEBPG ZNF398 ZIC2 FHDC1 TMEM131L GC04P153070 GC04P153071 TRIM2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FHDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FHDC1 Gene

Chromosome:
4
Start:
152,911,570 bp from pter
End:
152,979,696 bp from pter
Size:
68,127 bases
Orientation:
Plus strand

Genomic View for FHDC1 Gene

Genes around FHDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FHDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FHDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHDC1 Gene

Proteins for FHDC1 Gene

  • Protein details for FHDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0D6-FHDC1_HUMAN
    Recommended name:
    FH2 domain-containing protein 1
    Protein Accession:
    Q9C0D6

    Protein attributes for FHDC1 Gene

    Size:
    1143 amino acids
    Molecular mass:
    124762 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FHDC1 Gene

Post-translational modifications for FHDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FHDC1 Gene

No data available for DME Specific Peptides for FHDC1 Gene

Domains & Families for FHDC1 Gene

Protein Domains for FHDC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FHDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FHDC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FHDC1 Gene

Function for FHDC1 Gene

Phenotypes for FHDC1 Gene

genes like me logo Genes that share phenotypes with FHDC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FHDC1 Gene

Localization for FHDC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FHDC1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FHDC1 Gene

Pathways & Interactions for FHDC1 Gene

SuperPathways for FHDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FHDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FHDC1 Gene

Drugs & Compounds for FHDC1 Gene

No Compound Related Data Available

Transcripts for FHDC1 Gene

mRNA/cDNA for FHDC1 Gene

Unigene Clusters for FHDC1 Gene

FH2 domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FHDC1 Gene

No ASD Table

Relevant External Links for FHDC1 Gene

GeneLoc Exon Structure for
FHDC1
ECgene alternative splicing isoforms for
FHDC1

Expression for FHDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FHDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FHDC1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.7), Skin - Not Sun Exposed (Suprapubic) (x4.4), and Thyroid (x4.0).

Protein differential expression in normal tissues from HIPED for FHDC1 Gene

This gene is overexpressed in Cervix (31.7), Breast (23.7), and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FHDC1 Gene



Protein tissue co-expression partners for FHDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FHDC1 Gene:

FHDC1

SOURCE GeneReport for Unigene cluster for FHDC1 Gene:

Hs.132629
genes like me logo Genes that share expression patterns with FHDC1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FHDC1 Gene

Orthologs for FHDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FHDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FHDC1 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia FHDC1 34 35
  • 80.97 (n)
rat
(Rattus norvegicus)
Mammalia Fhdc1 34
  • 76.69 (n)
mouse
(Mus musculus)
Mammalia Fhdc1 34 16 35
  • 76.09 (n)
cow
(Bos Taurus)
Mammalia FHDC1 34 35
  • 75.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FHDC1 35
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FHDC1 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves FHDC1 34 35
  • 60.29 (n)
lizard
(Anolis carolinensis)
Reptilia FHDC1 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fhdc1 34
  • 55.26 (n)
zebrafish
(Danio rerio)
Actinopterygii fhdc1 34 35
  • 50.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta form3 35
  • 19 (a)
OneToOne
Species where no ortholog for FHDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FHDC1 Gene

ENSEMBL:
Gene Tree for FHDC1 (if available)
TreeFam:
Gene Tree for FHDC1 (if available)

Paralogs for FHDC1 Gene

Paralogs for FHDC1 Gene

genes like me logo Genes that share paralogs with FHDC1: view

Variants for FHDC1 Gene

Sequence variations from dbSNP and Humsavar for FHDC1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000072036 -- 152,942,328(+) TTTTC(A/T)TATCT intron-variant, upstream-variant-2KB
rs1000076524 -- 152,948,959(+) TGGCT(C/T)GTGCC intron-variant
rs1000077679 -- 152,936,523(+) AGGCT(C/G)AGGCG intron-variant, upstream-variant-2KB
rs1000083430 -- 152,914,330(+) ACAGG(A/C)AACGA intron-variant
rs1000119070 -- 152,956,485(+) TTTTC(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FHDC1 Gene

Variant ID Type Subtype PubMed ID
nsv461691 CNV loss 19166990
nsv509019 CNV insertion 20534489
nsv595745 CNV loss 21841781
nsv830117 CNV gain 17160897

Variation tolerance for FHDC1 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.31; 97.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FHDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FHDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHDC1 Gene

Disorders for FHDC1 Gene

Relevant External Links for FHDC1

Genetic Association Database (GAD)
FHDC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FHDC1

No disorders were found for FHDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FHDC1 Gene

Publications for FHDC1 Gene

  1. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. (PMID: 17362836) Schymick J.C. … Traynor B.J. (Lancet Neurol 2007) 3 46 64
  2. Identification and characterization of human FHDC1, mouse Fhdc1 and zebrafish fhdc1 genes in silico. (PMID: 15138637) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 64
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  5. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J. … Vissers L.E. (N. Engl. J. Med. 2012) 4 64

Products for FHDC1 Gene

Sources for FHDC1 Gene

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