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FHAD1 Gene(Protein Coding)

Forkhead Associated Phosphopeptide Binding Domain 1

GCID:
GC01P015248
GIFtS:
41
Genes Participants
UDN Logo

Aliases for FHAD1 Gene

Aliases for FHAD1 Gene

  • Forkhead Associated Phosphopeptide Binding Domain 1 2 3 5
  • Forkhead-Associated (FHA) Phosphopeptide Binding Domain 1 2
  • FHA Domain-Containing Protein 1 4
  • KIAA1937 4

External Ids for FHAD1 Gene

Previous GeneCards Identifiers for FHAD1 Gene

  • GC01P015309
  • GC01P015435
  • GC01P015563
  • GC01P014095

Summaries for FHAD1 Gene

GeneCards Summary for FHAD1 Gene

FHAD1 (Forkhead Associated Phosphopeptide Binding Domain 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHAD1 Gene

Genomics for FHAD1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FHAD1 Gene

Enhancers for FHAD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G015258 2 FANTOM5 Ensembl ENCODE dbSUPER 14.7 +24.1 24077 3.8 HNRNPUL1 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B FOS SP5 NFYC SPEN FHAD1 LOC101927417 ENSG00000237938 PLEKHM2 TMEM51 EFHD2 CASP9 PIR39012
GH01G015406 2 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +177.0 177043 13.8 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SPEN EFHD2 LOC101927441 CTRC LOC101927417 FHAD1 CASP9 PLEKHM2 ENSG00000224621 DDI2
GH01G015245 1.5 FANTOM5 ENCODE dbSUPER 15 +10.0 9987 2.3 SIN3A ZNF121 GLIS2 ZNF207 ZNF263 SP3 ZHX2 ZNF623 RFX3 GLIS1 FHAD1 LOC101927417 PLEKHM2 TMEM51 EFHD2 CASP9 PIR39012
GH01G015322 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +87.8 87760 2.7 PKNOX1 ARNT TCF12 ZNF766 ZNF143 KLF13 REST ZNF592 MAFF SMARCA4 FHAD1 CTRC CASP9 EFHD2 PLEKHM2 ENSG00000236045 PIR39012
GH01G015249 1.3 FANTOM5 ENCODE 15.7 +12.8 12753 0.4 PKNOX1 ZFP64 ZNF121 ZNF354C KLF7 RELB ETV6 IKZF2 CREM ZNF680 SPEN ENSG00000237938 FHAD1 LOC101927417 RPS16P1 TMEM51 PLEKHM2 EFHD2 PIR39012
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FHAD1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FHAD1 gene promoter:

Genomic Location for FHAD1 Gene

Chromosome:
1
Start:
15,236,602 bp from pter
End:
15,400,283 bp from pter
Size:
163,682 bases
Orientation:
Plus strand

Genomic View for FHAD1 Gene

Genes around FHAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FHAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FHAD1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FHAD1 Gene

Proteins for FHAD1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FHAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B1AJZ9-FHAD1_HUMAN
    Recommended name:
    Forkhead-associated domain-containing protein 1
    Protein Accession:
    B1AJZ9
    Secondary Accessions:
    • Q0P6F5
    • Q8N8D3
    • Q8N9T6
    • Q8NA05

    Protein attributes for FHAD1 Gene

    Size:
    1412 amino acids
    Molecular mass:
    161904 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04126.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04242.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04913.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI21427.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21811.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23268.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FHAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FHAD1 Gene

Protein Expression for FHAD1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FHAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FHAD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FHAD1 Gene

Domains & Families for FHAD1 Gene

No data available for Gene Families and UniProtKB/Swiss-Prot for FHAD1 Gene

Function for FHAD1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Phenotypes for FHAD1 Gene

GenomeRNAi human phenotypes for FHAD1:
genes like me logo Genes that share phenotypes with FHAD1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FHAD1 Gene

Localization for FHAD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FHAD1 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FHAD1 Gene

Pathways & Interactions for FHAD1 Gene

SuperPathways for FHAD1 Gene

PathCards logo More details on SuperPathways for FHAD1
No Data Available

Interacting Proteins for FHAD1 Gene

Selected Interacting proteins: B1AJZ9-FHAD1_HUMAN for FHAD1 Gene via IID

Symbol External ID(s) Details
YWHAE

Gene Ontology (GO) - Biological Process for FHAD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FHAD1 Gene

Drugs & Compounds for FHAD1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FHAD1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FHAD1 Gene

(34) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(48) Selected AceView cDNA sequences:
(22) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FHAD1 Gene

Forkhead-associated (FHA) phosphopeptide binding domain 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FHAD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: - - - - - -
SP6:
SP7: - - -
SP8: -
SP9:
SP10:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c ^ 34
SP1: - - - - -
SP2: -
SP3: - - - - - - - -
SP4: - - - -
SP5:
SP6: - - - - - -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for FHAD1 Gene

GeneLoc Exon Structure for
FHAD1
ECgene alternative splicing isoforms for
FHAD1

Expression for FHAD1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FHAD1 Gene

mRNA expression in normal human tissues for FHAD1 Gene
mRNA expression by BioGPS for FHAD1 GenemRNA expression by GTEx for FHAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FHAD1 Gene

This gene is overexpressed in Testis (x21.5).

Protein differential expression in normal tissues from HIPED for FHAD1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (39.8) and Plasma (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FHAD1 Gene



Protein tissue co-expression partners for FHAD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FHAD1 Gene:

FHAD1

SOURCE GeneReport for Unigene cluster for FHAD1 Gene:

Hs.659997
genes like me logo Genes that share expression patterns with FHAD1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FHAD1 Gene

Orthologs for FHAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FHAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FHAD1 35 34
  • 98.35 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia FHAD1 35 34
  • 81.49 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia FHAD1 35 34
  • 80.87 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Fhad1 35 16 34
  • 74.9 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Fhad1 34
  • 74.56 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 40 (a)
 OneToMany
-- 35
  • 15 (a)
 OneToMany
-- 35
  • 2 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia FHAD1 35
  • 7 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LOC771735 34
  • 57.54 (n)
FHAD1 35
  • 3 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia FHAD1 35
  • 6 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii FHAD1 (1 of 2) 35
  • 8 (a)
 OneToMany
FHAD1 (2 of 2) 35
  • 5 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 8 (a)
 OneToOne
Species where no ortholog for FHAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FHAD1 Gene

ENSEMBL:
Gene Tree for FHAD1 (if available)
TreeFam:
Gene Tree for FHAD1 (if available)

Paralogs for FHAD1 Gene

(1) SIMAP similar genes for FHAD1 Gene using alignment to 11 proteins:

genes like me logo Genes that share paralogs with FHAD1: view

No data available for Paralogs for FHAD1 Gene

Variants for FHAD1 Gene

Sequence variations from dbSNP and Humsavar for FHAD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000022013 -- 15,252,997(+) TAGAC(C/T)TTTTT intron-variant
rs1000053098 -- 15,375,285(+) GGGGC(C/G)CACTG intron-variant
rs1000063159 -- 15,334,086(+) CTCCC(A/G)AAGTG intron-variant
rs1000074432 -- 15,297,267(+) AGGGA(A/G)TGAGA intron-variant
rs1000090329 -- 15,289,279(+) CACCC(C/T)GCCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FHAD1 Gene

Variant ID Type Subtype PubMed ID
esv2508152 CNV insertion 19546169
esv2671419 CNV deletion 23128226
esv27394 CNV gain 19812545
esv2744297 CNV deletion 23290073
esv2762133 CNV loss 21179565
esv28285 CNV loss 19812545
esv3585308 CNV loss 21293372
esv3585309 CNV loss 21293372
nsv1007255 CNV loss 25217958
nsv460561 CNV loss 19166990
nsv472480 CNV novel sequence insertion 20440878
nsv475629 CNV novel sequence insertion 20440878
nsv478487 CNV novel sequence insertion 20440878
nsv517234 CNV gain 19592680
nsv545594 CNV loss 21841781
nsv833425 CNV gain 17160897
nsv833536 CNV loss 17160897

Variation tolerance for FHAD1 Gene

Gene Damage Index Score: 18.24; 98.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FHAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FHAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHAD1 Gene

Disorders for FHAD1 Gene

Relevant External Links for FHAD1

Genetic Association Database (GAD)
FHAD1
Human Genome Epidemiology (HuGE) Navigator
FHAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FHAD1

No disorders were found for FHAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FHAD1 Gene

Publications for FHAD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 64
  5. Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer. (PMID: 27358489) Zhao S. … Stanford J.L. (Clin. Cancer Res. 2017) 3 64

Products for FHAD1 Gene

Sources for FHAD1 Gene

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