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Aliases for FHAD1 Gene

Aliases for FHAD1 Gene

  • Forkhead Associated Phosphopeptide Binding Domain 1 2 3 5
  • Forkhead-Associated (FHA) Phosphopeptide Binding Domain 1 2
  • FHA Domain-Containing Protein 1 4
  • KIAA1937 4

External Ids for FHAD1 Gene

Previous GeneCards Identifiers for FHAD1 Gene

  • GC01P015309
  • GC01P015435
  • GC01P015563
  • GC01P014095

Summaries for FHAD1 Gene

GeneCards Summary for FHAD1 Gene

FHAD1 (Forkhead Associated Phosphopeptide Binding Domain 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHAD1 Gene

Genomics for FHAD1 Gene

Regulatory Elements for FHAD1 Gene

Enhancers for FHAD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F015248 1.4 FANTOM5 Ensembl ENCODE 15.7 +12.5 12485 1.0 PKNOX1 ZFP64 RAD21 YY1 ZNF121 ZNF354C KLF7 CREM ZNF680 ZNF654 SPEN ENSG00000237938 RPS16P1 FHAD1 LOC101927417 ENSG00000224621 DNAJC16 TMEM51 PLEKHM2 EFHD2
GH01F015245 1.2 FANTOM5 ENCODE 15 +10.0 9987 2.3 ZNF76 SIN3A BMI1 ZNF121 GLIS2 ELK1 ZNF391 ZHX1 ZNF263 ZNF280D FHAD1 LOC101927417 PLEKHM2 TMEM51 EFHD2 CASP9 PIR39012
GH01F015258 1.1 FANTOM5 Ensembl ENCODE 14.7 +23.7 23699 4.6 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF143 ZNF207 SPEN ENSG00000237938 FHAD1 LOC101927417 ENSG00000224621 PLEKHM2 RPS16P1 DNAJC16 TMEM51 EFHD2
GH01F015322 1.5 FANTOM5 Ensembl ENCODE 11.8 +87.8 87760 2.7 HDAC1 PKNOX1 ARNT ZBTB40 RAD21 RFX5 ZNF143 KDM4B EGR2 ZNF654 FHAD1 CTRC CASP9 EFHD2 PLEKHM2 ENSG00000236045 PIR39012
GH01F015137 1 Ensembl ENCODE 11.7 -97.4 -97442 3.6 PKNOX1 MLX ARID4B ZNF48 FOS SP5 NFYC MIER2 REST TSHZ1 TMEM51 FHAD1 TMEM51-AS1 GC01M015029
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FHAD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FHAD1 Gene

Chromosome:
1
Start:
15,236,602 bp from pter
End:
15,400,283 bp from pter
Size:
163,682 bases
Orientation:
Plus strand

Genomic View for FHAD1 Gene

Genes around FHAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FHAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FHAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHAD1 Gene

Proteins for FHAD1 Gene

  • Protein details for FHAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B1AJZ9-FHAD1_HUMAN
    Recommended name:
    Forkhead-associated domain-containing protein 1
    Protein Accession:
    B1AJZ9
    Secondary Accessions:
    • Q0P6F5
    • Q8N8D3
    • Q8N9T6
    • Q8NA05

    Protein attributes for FHAD1 Gene

    Size:
    1412 amino acids
    Molecular mass:
    161904 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04126.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04242.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04913.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI21427.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21811.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23268.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FHAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FHAD1 Gene

Post-translational modifications for FHAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FHAD1 Gene

Domains & Families for FHAD1 Gene

Protein Domains for FHAD1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

B1AJZ9

UniProtKB/Swiss-Prot:

FHAD1_HUMAN :
  • Contains 1 FHA domain.
Domain:
  • Contains 1 FHA domain.
genes like me logo Genes that share domains with FHAD1: view

No data available for Gene Families for FHAD1 Gene

Function for FHAD1 Gene

Phenotypes for FHAD1 Gene

GenomeRNAi human phenotypes for FHAD1:
genes like me logo Genes that share phenotypes with FHAD1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FHAD1 Gene

Localization for FHAD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FHAD1 Gene COMPARTMENTS Subcellular localization image for FHAD1 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FHAD1 Gene

Pathways & Interactions for FHAD1 Gene

SuperPathways for FHAD1 Gene

No Data Available

Interacting Proteins for FHAD1 Gene

Selected Interacting proteins: B1AJZ9-FHAD1_HUMAN for FHAD1 Gene via IID

Symbol External ID(s) Details
YWHAE

Gene Ontology (GO) - Biological Process for FHAD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FHAD1 Gene

Transcripts for FHAD1 Gene

Unigene Clusters for FHAD1 Gene

Forkhead-associated (FHA) phosphopeptide binding domain 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FHAD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: - - - - - -
SP6:
SP7: - - -
SP8: -
SP9:
SP10:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c ^ 34
SP1: - - - - -
SP2: -
SP3: - - - - - - - -
SP4: - - - -
SP5:
SP6: - - - - - -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for FHAD1 Gene

GeneLoc Exon Structure for
FHAD1
ECgene alternative splicing isoforms for
FHAD1

Expression for FHAD1 Gene

mRNA expression in normal human tissues for FHAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FHAD1 Gene

This gene is overexpressed in Testis (x21.5).

Protein differential expression in normal tissues from HIPED for FHAD1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (39.8) and Plasma (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FHAD1 Gene



Protein tissue co-expression partners for FHAD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FHAD1 Gene:

FHAD1

SOURCE GeneReport for Unigene cluster for FHAD1 Gene:

Hs.659997
genes like me logo Genes that share expression patterns with FHAD1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FHAD1 Gene

Orthologs for FHAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FHAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FHAD1 34 35
  • 98.35 (n)
dog
(Canis familiaris)
Mammalia FHAD1 34 35
  • 81.49 (n)
cow
(Bos Taurus)
Mammalia FHAD1 34 35
  • 80.87 (n)
mouse
(Mus musculus)
Mammalia Fhad1 34 16 35
  • 74.9 (n)
rat
(Rattus norvegicus)
Mammalia Fhad1 34
  • 74.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 40 (a)
OneToMany
-- 35
  • 15 (a)
OneToMany
-- 35
  • 2 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FHAD1 35
  • 7 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC771735 34
  • 57.54 (n)
FHAD1 35
  • 3 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FHAD1 35
  • 6 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FHAD1 (1 of 2) 35
  • 8 (a)
OneToMany
FHAD1 (2 of 2) 35
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 8 (a)
OneToOne
Species where no ortholog for FHAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FHAD1 Gene

ENSEMBL:
Gene Tree for FHAD1 (if available)
TreeFam:
Gene Tree for FHAD1 (if available)

Paralogs for FHAD1 Gene

genes like me logo Genes that share paralogs with FHAD1: view

No data available for Paralogs for FHAD1 Gene

Variants for FHAD1 Gene

Sequence variations from dbSNP and Humsavar for FHAD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1007571 -- 15,352,681(+) ACTAA(A/G)ATATG intron-variant
rs1010294 -- 15,382,044(-) CTCAA(C/T)GGACA reference, missense
rs10127455 -- 15,324,923(+) TCCCC(C/T)TGGGC intron-variant
rs10127456 -- 15,327,376(+) CATTC(A/G)GGCTT intron-variant
rs10128011 -- 15,327,508(+) GAGGG(G/T)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FHAD1 Gene

Variant ID Type Subtype PubMed ID
esv2508152 CNV insertion 19546169
esv2671419 CNV deletion 23128226
esv27394 CNV gain 19812545
esv2744297 CNV deletion 23290073
esv2762133 CNV loss 21179565
esv28285 CNV loss 19812545
esv3585308 CNV loss 21293372
esv3585309 CNV loss 21293372
nsv1007255 CNV loss 25217958
nsv460561 CNV loss 19166990
nsv472480 CNV novel sequence insertion 20440878
nsv475629 CNV novel sequence insertion 20440878
nsv478487 CNV novel sequence insertion 20440878
nsv517234 CNV gain 19592680
nsv545594 CNV loss 21841781
nsv833425 CNV gain 17160897
nsv833536 CNV loss 17160897

Variation tolerance for FHAD1 Gene

Gene Damage Index Score: 18.24; 98.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FHAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FHAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHAD1 Gene

Disorders for FHAD1 Gene

Relevant External Links for FHAD1

Genetic Association Database (GAD)
FHAD1
Human Genome Epidemiology (HuGE) Navigator
FHAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FHAD1

No disorders were found for FHAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FHAD1 Gene

Publications for FHAD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for FHAD1 Gene

Sources for FHAD1 Gene

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