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Aliases for FGR Gene

Aliases for FGR Gene

  • FGR Proto-Oncogene, Src Family Tyrosine Kinase 2 3 5
  • Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog 2 3 4
  • V-Fgr Feline Gardner-Rasheed Sarcoma Viral Oncogene Homolog 2 3
  • Feline Gardner-Rasheed Sarcoma Viral Oncogene Homolog 2 3
  • Proto-Oncogene C-Fgr 3 4
  • EC 2.7.10.2 4 63
  • P58c-Fgr 3 4
  • P55-Fgr 3 4
  • P58-Fgr 3 4
  • SRC2 3 4
  • Proto-Oncogene Tyrosine-Protein Kinase FGR 3
  • C-Src-2 Proto-Oncogene 3
  • C-Fgr Protooncogene 3
  • P55-C-Fgr Protein 3
  • EC 2.7.10 63
  • P55c-Fgr 3
  • C-Src2 3
  • C-Fgr 3

External Ids for FGR Gene

Previous HGNC Symbols for FGR Gene

  • SRC2

Previous GeneCards Identifiers for FGR Gene

  • GC01P027512
  • GC01M026912
  • GC01M027171
  • GC01M027543
  • GC01M027811
  • GC01M027938
  • GC01M026195

Summaries for FGR Gene

Entrez Gene Summary for FGR Gene

  • This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGR Gene

FGR (FGR Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FGR include sarcoma and hematologic cancer. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ABL2.

UniProtKB/Swiss-Prot for FGR Gene

  • Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.

Gene Wiki entry for FGR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGR Gene

Genomics for FGR Gene

Regulatory Elements for FGR Gene

Promoters for FGR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FGR on UCSC Golden Path with GeneCards custom track

Genomic Location for FGR Gene

Chromosome:
1
Start:
27,612,064 bp from pter
End:
27,635,561 bp from pter
Size:
23,498 bases
Orientation:
Minus strand

Genomic View for FGR Gene

Genes around FGR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGR Gene

Proteins for FGR Gene

  • Protein details for FGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09769-FGR_HUMAN
    Recommended name:
    Tyrosine-protein kinase Fgr
    Protein Accession:
    P09769
    Secondary Accessions:
    • D3DPL7
    • Q9UIQ3

    Protein attributes for FGR Gene

    Size:
    529 amino acids
    Molecular mass:
    59479 Da
    Quaternary structure:
    • Interacts with ITGB1, ITGB2, MS4A2/FCER1B, FCER1G, FCGR2A and/or FCGR2B. Interacts (via SH2 domain) with SYK (tyrosine phosphorylated). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with PTK2/FAK1. Interacts (via SH2 domain) with HCLS1 (tyrosine phosphorylated by SYK). Interacts with SIRPA and PTPNS1. Interacts (not phosphorylated on tyrosine residues) with CBL; FGR tyrosine phosphorylation promotes dissociation. Interacts with PIK3R1 and FASLG (By similarity).

neXtProt entry for FGR Gene

Proteomics data for FGR Gene at MOPED

Post-translational modifications for FGR Gene

  • Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.
  • Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGR Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FGR (FGR)

Domains & Families for FGR Gene

Suggested Antigen Peptide Sequences for FGR Gene

Graphical View of Domain Structure for InterPro Entry

P09769

UniProtKB/Swiss-Prot:

FGR_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with FGR: view

Function for FGR Gene

Molecular function for FGR Gene

GENATLAS Biochemistry:
Gardner-Rasheed feline sarcoma viral (c-fgr) oncogene homolog
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412. Activated by phorbol myristate acetate, phosphatidic acid and poly-Lys. Binding (via SH2 domain) of HCLS1 that is already phosphorylated by SYK strongly increases kinase activity.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.

Enzyme Numbers (IUBMB) for FGR Gene

Gene Ontology (GO) - Molecular Function for FGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with FGR: view
genes like me logo Genes that share phenotypes with FGR: view

Animal Models for FGR Gene

MGI Knock Outs for FGR:

Animal Model Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGR Gene

Localization for FGR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGR Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane. Mitochondrion intermembrane space. Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGR Gene COMPARTMENTS Subcellular localization image for FGR gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
cytoskeleton 4
mitochondrion 4
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with FGR: view

Pathways & Interactions for FGR Gene

genes like me logo Genes that share pathways with FGR: view

SIGNOR curated interactions for FGR Gene

Activates:

Gene Ontology (GO) - Biological Process for FGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002768 immune response-regulating cell surface receptor signaling pathway TAS 8327512
GO:0007229 integrin-mediated signaling pathway ISS --
GO:0009615 response to virus TAS 3003578
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP 10739672
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FGR: view

Drugs & Compounds for FGR Gene

(18) Drugs for FGR Gene - From: Novoseek, HMDB, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Phosphodiesterase 5 Inhibitors Pharma 513
Phosphodiesterase Inhibitors Pharma 1062
Sildenafil Citrate Pharma Treat erectile dysfunction and PAH 304
Vasodilator Agents Pharma 2926

(11) Additional Compounds for FGR Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with FGR: view

Transcripts for FGR Gene

Unigene Clusters for FGR Gene

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGR Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^
SP1: - - - - - - - - - - -
SP2: - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - -
SP13:
SP14: - - - - - - - - - -
SP15: - - - - - - - -
SP16: -

ExUns: 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: -
SP3: - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for FGR Gene

GeneLoc Exon Structure for
FGR
ECgene alternative splicing isoforms for
FGR

Expression for FGR Gene

mRNA expression in normal human tissues for FGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGR Gene

This gene is overexpressed in Whole Blood (x36.9).

Protein differential expression in normal tissues from HIPED for FGR Gene

This gene is overexpressed in Monocytes (30.3), Peripheral blood mononuclear cells (18.4), and Cervix (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGR Gene



SOURCE GeneReport for Unigene cluster for FGR Gene Hs.1422

mRNA Expression by UniProt/SwissProt for FGR Gene

P09769-FGR_HUMAN
Tissue specificity: Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.
genes like me logo Genes that share expression patterns with FGR: view

Protein tissue co-expression partners for FGR Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for FGR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FGR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGR 35
  • 99.43 (n)
  • 99.62 (a)
FGR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGR 36
  • 90 (a)
OneToOne
FGR 35
  • 89.18 (n)
  • 90.32 (a)
dog
(Canis familiaris)
Mammalia FGR 35
  • 88.99 (n)
  • 89.37 (a)
FGR 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgr 16
Fgr 36
  • 86 (a)
OneToOne
Fgr 35
  • 84.59 (n)
  • 86.07 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FGR 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgr 35
  • 84.72 (n)
  • 87.04 (a)
chicken
(Gallus gallus)
Aves YRK 35
  • 75.16 (n)
  • 73.56 (a)
FGR 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493811 35
  • 69.06 (n)
  • 74.37 (a)
zebrafish
(Danio rerio)
Actinopterygii yrk 36
  • 70 (a)
ManyToMany
Dr.12726 35
yrk 35
  • 69.93 (n)
  • 72.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Src64B 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea F57B9.8 37
  • 33 (a)
src-1 37
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA1 38
SLA1 38
Species with no ortholog for FGR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FGR Gene

ENSEMBL:
Gene Tree for FGR (if available)
TreeFam:
Gene Tree for FGR (if available)

Paralogs for FGR Gene

Paralogs for FGR Gene

genes like me logo Genes that share paralogs with FGR: view

Variants for FGR Gene

Sequence variations from dbSNP and Humsavar for FGR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34597831 - 27,623,042(+) CTTAC(A/G/T)TATTG intron-variant, nc-transcript-variant, reference, missense
rs35334091 - 27,621,597(+) TAGTT(C/G)CTGGG nc-transcript-variant, reference, missense
rs1292088 -- 27,634,944(-) GACAC(A/C)TGAGC intron-variant
rs1890462 -- 27,627,516(+) atagc(A/G)cttac intron-variant, upstream-variant-2KB
rs1890463 -- 27,621,740(-) TCTCT(A/G)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGR Gene

Variant ID Type Subtype PubMed ID
dgv14n27 CNV Loss 19166990
dgv205n71 CNV Loss 21882294
nsv522842 CNV Gain 19592680
dgv207n71 CNV Loss 21882294
nsv508700 CNV Loss 20534489

Variation tolerance for FGR Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGR Gene

HapMap Linkage Disequilibrium report
FGR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGR Gene

Disorders for FGR Gene

MalaCards: The human disease database

(2) MalaCards diseases for FGR Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
hematologic cancer
  • blood cancer
- elite association - COSMIC cancer census association via MalaCards
Search FGR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGR_HUMAN
  • Note=Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation.

Relevant External Links for FGR

Genetic Association Database (GAD)
FGR
Human Genome Epidemiology (HuGE) Navigator
FGR
Tumor Gene Database (TGDB):
FGR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGR
genes like me logo Genes that share disorders with FGR: view

No data available for Genatlas for FGR Gene

Publications for FGR Gene

  1. Fgr but not Syk tyrosine kinase is a target for beta 2 integrin- induced c-Cbl-mediated ubiquitination in adherent human neutrophils. (PMID: 12435267) Melander F. … Dib K. (Biochem. J. 2003) 3 4 23 67
  2. Sorting of Fas ligand to secretory lysosomes is regulated by mono- ubiquitylation and phosphorylation. (PMID: 17164290) Zuccato E. … Griffiths G.M. (J. Cell Sci. 2007) 3 23
  3. CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. (PMID: 10229804) Mikhalap S.V. … Sidorenko S.P. (J. Immunol. 1999) 3 23
  4. Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains. (PMID: 8824280) Finan P.M. … Kellie S. (J. Biol. Chem. 1996) 3 23
  5. Identification of a phorbol ester responsive region in the myeloid-specific promoter of the c-fgr proto-oncogene. (PMID: 7726865) Kefalas P. … Brickell P.M. (Biochem. Biophys. Res. Commun. 1995) 3 23

Products for FGR Gene

Sources for FGR Gene

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