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FGR Gene

protein-coding   GIFtS: 73
GCID: GC01M027938

Feline Gardner-Rasheed Sarcoma Viral Oncogene Homolog

(Previous names: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog,...)
(Previous symbol: SRC2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Feline Gardner-Rasheed Sarcoma Viral Oncogene Homolog1 2     C-Src-2 Proto-Oncogene2
SRC21 2 3 5     c-src22
Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog1 2 3     P55-C-Fgr Protein2
V-Fgr Feline Gardner-Rasheed Sarcoma Viral Oncogene Homolog1 2     p55c-fgr2
Proto-Oncogene C-Fgr2 3     p58c-fgr2
p55-Fgr2 3     Proto-Oncogene Tyrosine-Protein Kinase FGR2
p58-Fgr2 3     Tyrosine-Protein Kinase Fgr2
EC 2.7.10.23 8     p58c-Fgr3
c-fgr2     EC 2.7.108
C-Fgr Protooncogene2     

External Ids:    HGNC: 36971   Entrez Gene: 22682   Ensembl: ENSG000000009387   OMIM: 1649405   UniProtKB: P097693   

Export aliases for FGR gene to outside databases

Previous GC identifers: GC01P027512 GC01M026912 GC01M027171 GC01M027543 GC01M027622 GC01M027811 GC01M026195


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGR Gene:
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains
N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in
mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The
protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and
adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results
in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been
identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGR Gene:
FGR (feline Gardner-Rasheed sarcoma viral oncogene homolog) is a protein-coding gene. Diseases associated with FGR include placental insufficiency, and severe pre-eclampsia. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and protein kinase binding. An important paralog of this gene is FRK.

UniProtKB/Swiss-Prot: FGR_HUMAN, P09769
Function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase
activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and
mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion
and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis.
Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or
FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and
adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of
ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling,
normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell
migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and
promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated
mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and
diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and
subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1,
PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated
HCLS1

Gene Wiki entry for FGR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGR gene promoter:
         p53   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FGR promoter sequence
   Search Chromatin IP Primers for FGR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2-p36.1   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.2-p36.1

FGR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M027938:  view genomic region     (about GC identifiers)

Start:
27,938,575 bp from pter      End:
27,961,788 bp from pter
Size:
23,214 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FGR_HUMAN, P09769 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Fgr  
Size: 529 amino acids; 59479 Da
Subunit: Interacts with ITGB1, ITGB2, MS4A2/FCER1B, FCER1G, FCGR2A and/or FCGR2B. Interacts (via SH2 domain) with
SYK (tyrosine phosphorylated). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with
PTK2/FAK1. Interacts (via SH2 domain) with HCLS1 (tyrosine phosphorylated by SYK). Interacts with SIRPA and
PTPNS1. Interacts (not phosphorylated on tyrosine residues) with CBL; FGR tyrosine phosphorylation promotes
dissociation. Interacts with PIK3R1 and FASLG (By similarity)
Secondary accessions: D3DPL7 Q9UIQ3

Explore the universe of human proteins at neXtProt for FGR: NX_P09769

Explore proteomics data for FGR at MOPED

Post-translational modifications: 

  • Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation1
  • Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or
    FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits
    ulterior autophosphorylation at Tyr-4121
  • Ubiquitination2 at Lys177
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FGR (P09769) (see all 27)
     FLIRESE  PIYIVTE  LRHDKLV  KWTAPEA 


    See FGR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001036194.1  NP_001036212.1  NP_005239.1  

    ENSEMBL proteins: 
     ENSP00000363117   ENSP00000363116   ENSP00000363115   ENSP00000407670   ENSP00000445302  
     ENSP00000382126  
    Reactome Protein details: P09769

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
    Src family

    Selected InterPro protein domains (see all 9):
     IPR028459 FGR
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P09769

    ProtoNet protein and cluster: P09769

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FGR_HUMAN, P09769
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    FGR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGR_HUMAN, P09769
    Function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase
    activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and
    mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion
    and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis.
    Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or
    FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and
    adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of
    ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling,
    normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell
    migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and
    promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated
    mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and
    diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and
    subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1,
    PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated
    HCLS1
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by autophosphorylation. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior
    autophosphorylation at Tyr-412. Activated by phorbol myristate acetate, phosphatidic acid and poly-Lys. Binding
    (via SH2 domain) of HCLS1 that is already phosphorylated by SYK strongly increases kinase activity

         Genatlas biochemistry entry for FGR:
    Gardner-Rasheed feline sarcoma viral (c-fgr) oncogene homolog

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding ISS--
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity IDA7519620
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA8327512
    GO:0005515protein binding IPI16273093
         
    FGR for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for FGR:
     Decreased nuclei size in G2M  Decreased viability with TRAIL  Increased apoptosis  Increased mitotic index 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fgr):
     cardiovascular system  hematopoietic system  immune system  normal 

    FGR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FGR: Fgrtm1Hev Fgrtm2Hev

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGR

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate FGR:
    hsa-miR-4305 hsa-miR-708* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidFGR 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGR_HUMAN, P09769: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Cell membrane; Peripheral membrane
    protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton.
    Mitochondrion inner membrane (By similarity). Mitochondrion intermembrane space (By similarity). Note=Detected in
    mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at
    membrane ruffles. Detected at plasma membrane lipid rafts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    plasma membrane5
    extracellular2
    mitochondrion2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005829cytosol TAS--
    GO:0005856colocalizes with cytoskeleton IDA8603737
    GO:0005886plasma membrane ISS--

    FGR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGR About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Platelet homeostasis
    Platelet sensitization by LDL0.00
    Platelet homeostasis
    2Fcgamma receptor (FCGR) dependent phagocytosis
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    3Focal adhesion
    Focal Adhesion0.65
    4Creation of C4 and C2 activators
    FCGR activation0.54
    5Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for FGR
        Transendothelial Migration of Leukocytes

    1 Cell Signaling Technology (CST) Pathway for FGR
        Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for FGR
        Immune response CCR3 signaling in eosinophils

    Selected BioSystems Pathways for FGR (see all 14)
        Focal Adhesion
    Kit Receptor Signaling Pathway
    IL-6 Signaling Pathway
    Glypican 1 network
    amb2 Integrin signaling

    2 Reactome Pathways for FGR
        FCGR activation
    Platelet sensitization by LDL


    2 Kegg Pathways  (Kegg details for FGR):
        Chemokine signaling pathway
    Epstein-Barr virus infection


    FGR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGR: 
              Leukemia in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGR (P097691, 2, 3 ENSP000003631154) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-1383732,EBI-641062 MINT-74537 MINT-74536 MINT-74538 I2D: score=2 STRING: ENSP00000269571
    SYKP434052, 3, ENSP000003648984MINT-56739 I2D: score=5 STRING: ENSP00000364898
    WASP427682, 3, ENSP000003658914MINT-13728 I2D: score=4 STRING: ENSP00000365891
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908075 I2D: score=1 STRING: ENSP00000365312
    DAB2P980823, ENSP000003133914I2D: score=3 STRING: ENSP00000313391
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002768immune response-regulating cell surface receptor signaling pathway TAS8327512
    GO:0006468protein phosphorylation TAS2995972
    GO:0007229integrin-mediated signaling pathway ISS--
    GO:0007596blood coagulation TAS--
    GO:0008360regulation of cell shape ISS--

    FGR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGR

    2 HMDB Compounds for FGR    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for FGR gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 67.6 33 12435267 (2), 2179817 (2), 9409323 (2), 7786302 (1) (see all 26)
    piceatannol 62.2 1 12435267 (1)
    steroid 47.5 21 19264843 (2), 12082103 (1), 18048071 (1), 16357103 (1) (see all 17)
    zymosan 28.8 1 17173331 (1)
    fmlp 27.8 3 17339487 (3)
    genistein 26.8 1 20049867 (1)
    retinoid 23.5 2 12082103 (1), 15525597 (1)
    calcitriol 21.1 5 7726865 (2), 1628903 (2)
    leukotriene b4 14 1 15749899 (1)
    progesterone 13.8 5 18174919 (2)



    FGR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FGR gene (3 alternative transcripts): 
    NM_001042729.1  NM_001042747.1  NM_005248.2  

    Unigene Cluster for FGR:

    Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
    Hs.1422  [show with all ESTs]
    Unigene Representative Sequence: NM_001042747
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374005(uc001bol.3 uc001bom.3) ENST00000374004(uc001boj.3)
    ENST00000374003 ENST00000457296 ENST00000475472(uc021ojx.1) ENST00000468038
    ENST00000545953 ENST00000399173(uc001bok.3)
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    SwitchGear 3'UTR luciferase reporter plasmidFGR 3' UTR sequence
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    Additional mRNA sequence: 

    AK130188.1 AK301078.1 AK304846.1 BC064382.1 M27454.1 

    12 DOTS entries:

    DT.101981047  DT.97816677  DT.97841220  DT.101981048  DT.95092467  DT.92422455  DT.121402814  DT.121402853 
    DT.91667423  DT.91744878  DT.99930037  DT.411384 

    Selected AceView cDNA sequences (see all 127):

    CB529352 BX505943 AW291279 CB529266 AL548206 BQ448283 CR604589 BQ711268 
    M27454 BG176575 AA761325 BG745955 BM561907 CD365941 CA448709 AI090521 
    CR600467 BC064382 BM454242 CD364431 BU679660 BI018346 CB529777 AW952205 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FGR (see all 16)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^
    SP1:                                -     -     -     -     -     -     -                 -                 -     -     -                                       
    SP2:                                                                                                        -     -     -                                       
    SP3:                                                              -     -                 -           -     -     -     -     -     -     -     -     -     -   
    SP4:                                                  -     -     -     -                 -                 -     -     -                                       
    SP5:                                                              -     -                 -                 -     -     -                                       

    ExUns: 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                  -                                 
    SP2:                                                  -                                 
    SP3:  -     -     -     -     -     -     -     -                                       
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for FGR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FGR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTAGCCT
    FGR Expression
    About this image


    FGR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
     
     Spleen (Hematopoietic System)
    FGR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1422

    UniProtKB/Swiss-Prot: FGR_HUMAN, P09769
    Tissue specificity: Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in
    monocytes and large lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGR: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGR gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgr1 , 5 Gardner-Rasheed feline sarcoma viral (Fgr) oncogene more1, 5 84.59(n)1
    86.07(a)1
      4 (66.11 cM)5
    141911  NM_010208.41  NP_034338.31 
     1329740955 
    chicken
    (Gallus gallus)
    Aves YRK1 proto-oncogene tyrosine-protein kinase Yrk 75.16(n)
    73.56(a)
      777583  NM_001109787.1  NP_001103257.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    70(a)
    many ↔ many
    GL343464.1(630926-647703)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004938111 tyrosine-protein kinase Yes-like 69.06(n)
    74.37(a)
      100493811  XM_002934642.2  XP_002934688.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.127262 Danio rerio Yes-relayed kinase (yrk) mRNA, complete more 78.45(n)    AY169369.1 


    ENSEMBL Gene Tree for FGR (if available)
    TreeFam Gene Tree for FGR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGR gene
    FRK2  LCK2  BLK2  LYN2  PTK62  YES12  HCK2  ABL12  
    SRC2  FYN2  ABL22  SRMS2  
    Selected SIMAP similar genes for FGR using alignment to 5 protein entries:     FGR_HUMAN (see all proteins) (see all similar genes):
    c-fgr    SRC    BLK    LYN    HCK    YES1
    EPHA3    NCK2    ABL1    EPHA5    FRK    CD74/ROS fusion
    LRIG3(NM_001136051)-ROS1    LRIG3(NM_153377)-ROS1    R32    R34    ROS1    SLC34A2-ROS1

    FGR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for FGR (see all 531)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57731941,2
    C--26196421(+) atctc-/Aaaaaa 3 -- int1 trp30--------
    rs710103601,2
    C--26203711(+) GTCTC-/A/AAAA
            
    AAAAA
    3 -- int11NA 2
    rs1150409931,2
    C,F--27938381(+) CTCAGG/TCCTCT 3 -- ds50011Minor allele frequency- T:0.03NA 120
    rs791731291,2
    C--27938392(+) TCTCTA/CTCCTC 3 -- ds50010--------
    rs1835406931,2
    --27938524(+) CTGATG/TAACTC 3 -- ds50010--------
    rs1878380981,2
    --27938672(+) CTCCAC/TACCTT 3 -- ds50010--------
    rs1414480681,2
    --27938713(+) CCTCTC/GCAGCT 3 -- ds50010--------
    rs1469976561,2
    --27938732(+) TGCTGC/TCTGTA 3 -- ds50010--------
    rs1476794561,2
    --27938771(+) ACCACC/TCCCGC 3 -- ds50010--------
    rs8786481,2
    C,F,H--27938796(+) TCAAGG/TGTATT 3 -- ds50018Minor allele frequency- T:0.02EA NA NS 444

    HapMap Linkage Disequilibrium report for FGR (27938575 - 27961788 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FGR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508700CNV Loss20534489
    dgv205n71CNV Loss21882294
    dgv14n27CNV Loss19166990
    dgv207n71CNV Loss21882294
    nsv522842CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing FGR:
    Oncogenes & Tumor Suppressor Genes 384HC
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing FGR
    DNA2.0 Custom Variant and Variant Library Synthesis for FGR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 164940    OMIM disorders: --

    UniProtKB/Swiss-Prot: FGR_HUMAN, P09769
  • Note=Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant
    cell proliferation

  • Selected diseases for FGR (see all 28):    
    About MalaCards
    placental insufficiency    severe pre-eclampsia    sarcoma    pre-eclampsia
    eclampsia    thrombophilia    pharyngitis    wiskott-aldrich syndrome
    gout    periodontal disease    gastrointestinal stromal tumor    polycythemia
    periodontitis    chronic myeloid leukemia    rhabdomyosarcoma    myelodysplastic syndromes
    myeloid leukemia    lymphoblastic leukemia    neuroblastoma    hypoxia

    3 diseases from the University of Copenhagen DISEASES database for FGR:
    Lung cancer     Gastrointestinal stromal tumor     Leukemia

    FGR for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for FGR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    intrauterine growth retardation 41.6 5 1635741 (1), 18548400 (1), 9219458 (1), 9179534 (1) (see all 5)
    breast cancer 11 3 18174919 (1), 18540568 (1), 15525597 (1)
    necrosis 0 4 15811852 (2), 7726865 (1)
    tumors 0 6 15811852 (2), 2179817 (2), 10451706 (1)
    prostate cancer 0 1 19305643 (1)
    cancer 0 1 7690925 (1)

    Genetic Association Database (GAD): FGR
    Human Genome Epidemiology (HuGE) Navigator: FGR (10 documents)
    Tumor Gene Database (TGDB): FGR

    Export disorders for FGR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGR gene, integrated from 10 sources (see all 219):
    (articles sorted by number of sources associating them with FGR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fgr but not Syk tyrosine kinase is a target for beta 2 integrin- induced c-Cbl-mediated ubiquitination in adherent human neutrophils. (PubMed id 12435267)1, 2, 9 Melander F.... Dib K. (Biochem. J. 2003)
    2. Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites. (PubMed id 1690869)1, 2, 9 Patel M.... Brickell P.M. (Oncogene 1990)
    3. Sorting of Fas ligand to secretory lysosomes is regulated by mono- ubiquitylation and phosphorylation. (PubMed id 17164290)1, 2, 9 Zuccato E....Griffiths G.M. (J. Cell Sci. 2007)
    4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase. (PubMed id 10739672)1, 2 Axelsson L....Andersson T. (Exp. Cell Res. 2000)
    8. Activation of SRC family kinases in human neutrophils. Evidence that p58C-FGR and p53/56LYN redistributed to a Triton X-100-insoluble cytoskeletal fraction, also enriched in the caveolar protein caveolin, display an enhanced kinase activity. (PubMed id 8603737)1, 2 Yan S.R.... Berton G. (FEBS Lett. 1996)
    9. Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils. (PubMed id 7519620)1, 2 Berton G.... Sorio C. (J. Cell Biol. 1994)
    10. Association of immunoglobulin G Fc receptor II with Src-like protein- tyrosine kinase Fgr in neutrophils. (PubMed id 8327512)1, 2 Hamada F.... Toyoshima K. (Proc. Natl. Acad. Sci. U.S.A. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2268 HGNC: 3697 AceView: FGR Ensembl:ENSG00000000938 euGenes: HUgn2268
    ECgene: FGR Kegg: 2268 H-InvDB: FGR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FGR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGR gene:
    Search GeneIP for patents involving FGR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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