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FGR Gene(Protein Coding)

FGR Proto-Oncogene, Src Family Tyrosine Kinase

GCID:
GC01M027622
GIFtS:
67
Genes Participants
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Aliases for FGR Gene

Aliases for FGR Gene

  • FGR Proto-Oncogene, Src Family Tyrosine Kinase 2 3 5
  • Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog 2 3 4
  • V-Fgr Feline Gardner-Rasheed Sarcoma Viral Oncogene Homolog 2 3
  • Feline Gardner-Rasheed Sarcoma Viral Oncogene Homolog 2 3
  • Proto-Oncogene C-Fgr 3 4
  • EC 2.7.10.2 4 61
  • P58c-Fgr 3 4
  • P55-Fgr 3 4
  • P58-Fgr 3 4
  • SRC2 3 4
  • Proto-Oncogene Tyrosine-Protein Kinase FGR 3
  • Tyrosine-Protein Kinase Fgr 3
  • C-Src-2 Proto-Oncogene 3
  • C-Fgr Protooncogene 3
  • P55-C-Fgr Protein 3
  • EC 2.7.10 61
  • P55c-Fgr 3
  • C-Src2 3
  • C-Fgr 3

External Ids for FGR Gene

Previous HGNC Symbols for FGR Gene

  • SRC2

Previous GeneCards Identifiers for FGR Gene

  • GC01P027512
  • GC01M026912
  • GC01M027171
  • GC01M027543
  • GC01M027811
  • GC01M027938
  • GC01M026195

Summaries for FGR Gene

Entrez Gene Summary for FGR Gene

  • This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGR Gene

FGR (FGR Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FGR include Sarcoma and Spherocytosis, Type 1. Among its related pathways are Innate Immune System and Role of phospholipids in phagocytosis. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FYN.

UniProtKB/Swiss-Prot for FGR Gene

  • Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.

Gene Wiki entry for FGR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGR Gene

Genomics for FGR Gene

Products:

  1. Regulatory Element

Regulatory Elements for FGR Gene

Enhancers for FGR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G027614 2.1 FANTOM5 Ensembl ENCODE dbSUPER 29.5 +9.7 9724 23.4 MLX ZFP64 DMAP1 YBX1 FEZF1 YY1 ZNF143 ZNF263 SP3 MCM3 FGR ACTG1P20 THEMIS2 ENSG00000225886 XKR8 FAM76A TMEM222 RNU6-48P TRNAU1AP RPA2
GH01G027871 1.7 FANTOM5 ENCODE dbSUPER 30.3 -239.1 -239063 5.3 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 SIN3A FEZF1 GTF3C2 ZNF143 ZNF207 FGR THEMIS2 RPA2 XKR8 EYA3 GMEB1 PHACTR4 PTAFR SNHG12 ACTG1P20
GH01G027862 1.8 FANTOM5 Ensembl ENCODE dbSUPER 26.5 -228.6 -228640 4.4 HDAC1 HDGF PKNOX1 KLF17 RAD21 FOS RELB ETV6 IKZF2 ZBTB11 FGR THEMIS2 PTAFR XKR8 MED18 SESN2 STX12 EYA3 WASF2 PIR39917
GH01G027658 2 FANTOM5 Ensembl ENCODE dbSUPER 22.4 -25.7 -25692 6.3 HDGF PKNOX1 WRNIP1 ARID4B SIN3A ZNF143 ZNF207 FOS KLF13 DEK FGR THEMIS2 STX12 EYA3 GPN2 XKR8 FAM76A SYTL1 WASF2 ENSG00000233975
GH01G028110 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18 -477.0 -477040 4.4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A YY1 ZNF766 FOS PTAFR EYA3 FGR RNU6-176P RNU7-29P THEMIS2 SCARNA1 RNU6-1245P PPP1R8 SESN2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGR on UCSC Golden Path with GeneCards custom track

Promoters for FGR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003758 1061 1401 HDGF TBL1XR1 RB1 SIN3A YBX1 ZEB1 EGR1 ZNF143 RELB ETV6

Transcription factor binding sites by QIAGEN in the FGR gene promoter:

Genomic Location for FGR Gene

Chromosome:
1
Start:
27,612,064 bp from pter
End:
27,635,561 bp from pter
Size:
23,498 bases
Orientation:
Minus strand

Genomic View for FGR Gene

Genes around FGR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGR Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FGR Gene

Proteins for FGR Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09769-FGR_HUMAN
    Recommended name:
    Tyrosine-protein kinase Fgr
    Protein Accession:
    P09769
    Secondary Accessions:
    • D3DPL7
    • Q9UIQ3

    Protein attributes for FGR Gene

    Size:
    529 amino acids
    Molecular mass:
    59479 Da
    Quaternary structure:
    • Interacts with ITGB1, ITGB2, MS4A2/FCER1B, FCER1G, FCGR2A and/or FCGR2B. Interacts (via SH2 domain) with SYK (tyrosine phosphorylated). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with PTK2/FAK1. Interacts (via SH2 domain) with HCLS1 (tyrosine phosphorylated by SYK). Interacts with SIRPA and PTPNS1. Interacts (not phosphorylated on tyrosine residues) with CBL; FGR tyrosine phosphorylation promotes dissociation. Interacts with PIK3R1 and FASLG (By similarity).

neXtProt entry for FGR Gene

Protein Expression for FGR Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for FGR Gene

P09769:
  • KTLKPGTM
  • KWTAPEA
  • KHYKIRKLD
  • FLEDYFT
  • IKSDVWSFGILL
  • FLIRESE
  • FTIKSDVWSFG
  • NYIHRDLR
  • CKIADFGLAR
  • VSEEPIYIV
  • EGDWWEARS
  • PIYIVTE
  • RKDAERQLL
  • SLSIRDWD
  • DSIQAEEWY
  • VKHYKIR
  • ALYDYEARTEDDL
  • GRIPYPGM
  • HRDLRAANILV
  • LRHDKLV
  • KSDVWSFG
  • LPQLVDM
  • KFPIKWTAPE
  • RESETTKGA
  • KLVQLYAVV
  • PEERPTFE
  • EPQYQPG

Post-translational modifications for FGR Gene

  • Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.
  • Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FGR (FGR)

Domains & Families for FGR Gene

Gene Families for FGR Gene

HGNC:
IUPHAR :

Protein Domains for FGR Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FGR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09769

UniProtKB/Swiss-Prot:

FGR_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with FGR: view

Function for FGR Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FGR Gene

GENATLAS Biochemistry:
Gardner-Rasheed feline sarcoma viral (c-fgr) oncogene homolog
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412. Activated by phorbol myristate acetate, phosphatidic acid and poly-Lys. Binding (via SH2 domain) of HCLS1 that is already phosphorylated by SYK strongly increases kinase activity.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.

Enzyme Numbers (IUBMB) for FGR Gene

Gene Ontology (GO) - Molecular Function for FGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding ISS --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IDA,TAS 7519620
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS --
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with FGR: view
genes like me logo Genes that share phenotypes with FGR: view

Animal Models for FGR Gene

MGI Knock Outs for FGR:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGR Gene

Localization for FGR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGR Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane. Mitochondrion intermembrane space. Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGR gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
cytoskeleton 4
mitochondrion 4
nucleus 2

Gene Ontology (GO) - Cellular Components for FGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005758 mitochondrial intermembrane space IEA --
genes like me logo Genes that share ontologies with FGR: view

Pathways & Interactions for FGR Gene

genes like me logo Genes that share pathways with FGR: view

Pathways by source for FGR Gene

1 Cell Signaling Technology pathway for FGR Gene
1 GeneGo (Thomson Reuters) pathway for FGR Gene
1 Qiagen pathway for FGR Gene

SIGNOR curated interactions for FGR Gene

Activates:

Gene Ontology (GO) - Biological Process for FGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002768 immune response-regulating cell surface receptor signaling pathway TAS 8327512
GO:0006468 protein phosphorylation TAS 2995972
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007229 integrin-mediated signaling pathway ISS --
genes like me logo Genes that share ontologies with FGR: view

Drugs & Compounds for FGR Gene

Products:

  1. Drug

(21) Drugs for FGR Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Phosphodiesterase 5 Inhibitors Pharma 589
Phosphodiesterase Inhibitors Pharma 1289
Sildenafil Citrate Pharma Treat erectile dysfunction and PAH, Orally active, potent PDE5 inhibitor 331
Vasodilator Agents Pharma 3543

(8) Additional Compounds for FGR Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with FGR: view

Transcripts for FGR Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FGR Gene

(11) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(127) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGR Gene

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGR Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^
SP1: - - - - - - - - - - -
SP2: - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - -
SP13:
SP14: - - - - - - - - - -
SP15: - - - - - - - -
SP16: -

ExUns: 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: -
SP3: - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for FGR Gene

GeneLoc Exon Structure for
FGR
ECgene alternative splicing isoforms for
FGR

Expression for FGR Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGR Gene

mRNA expression in normal human tissues for FGR Gene
mRNA expression by BioGPS for FGR GenemRNA expression by GTEx for FGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGR Gene

This gene is overexpressed in Whole Blood (x36.9).

Protein differential expression in normal tissues from HIPED for FGR Gene

This gene is overexpressed in Monocytes (30.3), Peripheral blood mononuclear cells (18.4), and Cervix (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGR Gene



Protein tissue co-expression partners for FGR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FGR Gene:

FGR

SOURCE GeneReport for Unigene cluster for FGR Gene:

Hs.1422

mRNA Expression by UniProt/SwissProt for FGR Gene:

P09769-FGR_HUMAN
Tissue specificity: Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.

Evidence on tissue expression from TISSUES for FGR Gene

  • Nervous system(4.3)
  • Blood(4)
  • Spleen(2.9)
  • Bone marrow(2.8)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with FGR: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FGR Gene

Orthologs for FGR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FGR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FGR 35 34
  • 99.43 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia FGR 34 35
  • 89.18 (n)
dog
(Canis familiaris)
 Mammalia FGR 34 35
  • 88.99 (n)
rat
(Rattus norvegicus)
 Mammalia Fgr 34
  • 84.72 (n)
mouse
(Mus musculus)
 Mammalia Fgr 35 16 34
  • 84.59 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia FGR 35
  • 76 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FGR 35
  • 82 (a)
 OneToOne
YRK 34
  • 75.16 (n)
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 70 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100493811 34
  • 69.06 (n)
zebrafish
(Danio rerio)
 Actinopterygii yrk 34 35
  • 69.93 (n)
Dr.12726 34
fruit fly
(Drosophila melanogaster)
 Insecta Src64B 36
  • 51 (a)
worm
(Caenorhabditis elegans)
 Secernentea src-1 36
  • 45 (a)
F57B9.8 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SLA1 37 37
Species where no ortholog for FGR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FGR Gene

ENSEMBL:
Gene Tree for FGR (if available)
TreeFam:
Gene Tree for FGR (if available)

Paralogs for FGR Gene

Paralogs for FGR Gene

(151) SIMAP similar genes for FGR Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FGR: view

Variants for FGR Gene

Sequence variations from dbSNP and Humsavar for FGR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000393479 -- 27,632,531(+) ACTCC(A/T)CCACC intron-variant
rs1000463027 -- 27,637,284(+) CACCC(C/T)CAGCA upstream-variant-2KB
rs1000501558 -- 27,612,240(+) TGTCC(A/C/G)TTCAC downstream-variant-500B
rs1000575758 -- 27,613,761(+) TTCGG(A/G)GATCC intron-variant
rs1000802619 -- 27,631,546(+) CTGAG(C/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGR Gene

Variant ID Type Subtype PubMed ID
dgv14n27 CNV loss 19166990
dgv219n54 CNV loss 21841781
dgv220n54 CNV loss 21841781
nsv1014991 CNV gain 25217958
nsv508700 CNV deletion 20534489
nsv522842 CNV gain 19592680
nsv950343 CNV deletion 24416366

Variation tolerance for FGR Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGR Gene

Human Gene Mutation Database (HGMD)
FGR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGR Gene

Disorders for FGR Gene

MalaCards: The human disease database

(2) MalaCards diseases for FGR Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
spherocytosis, type 1
  • hereditary spherocytosis type 1
- elite association - COSMIC cancer census association via MalaCards
Search FGR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGR_HUMAN
  • Note=Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation.

Relevant External Links for FGR

Genetic Association Database (GAD)
FGR
Human Genome Epidemiology (HuGE) Navigator
FGR
Tumor Gene Database (TGDB):
FGR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGR
genes like me logo Genes that share disorders with FGR: view

No data available for Genatlas for FGR Gene

Publications for FGR Gene

  1. Sorting of Fas ligand to secretory lysosomes is regulated by mono- ubiquitylation and phosphorylation. (PMID: 17164290) Zuccato E. … Griffiths G.M. (J. Cell Sci. 2007) 3 4 22 64
  2. Fgr but not Syk tyrosine kinase is a target for beta 2 integrin- induced c-Cbl-mediated ubiquitination in adherent human neutrophils. (PMID: 12435267) Melander F. … Dib K. (Biochem. J. 2003) 3 4 22 64
  3. Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites. (PMID: 1690869) Patel M. … Brickell P.M. (Oncogene 1990) 3 4 22 64
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 46 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for FGR Gene

  • Addgene plasmids for FGR

Sources for FGR Gene

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