FGR Gene
protein-coding GIFtS: 71
GCID: GC01M027938
|
|
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
(Previous symbol: SRC2)
| |
Aliases
for FGR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog1 2 3 | | C-Src-2 Proto-Oncogene2 | | SRC21 2 3 5 | | C-Src21 | | C-Fgr1 | | P55-C-Fgr Protein2 | | P55c-Fgr1 | | P58c-Fgr1 | | Proto-Oncogene C-Fgr2 3 | | Proto-Oncogene Tyrosine-Protein Kinase FGR2 | | P55-Fgr1 | | Tyrosine-Protein Kinase Fgr2 | | P58-Fgr1 | | P58c-Fgr1 | | EC 2.7.10.23 8 | | EC 2.7.108 | | C-Fgr Protooncogene2 | | |
Export aliases for FGR gene to outside databasesPrevious GC identifers: GC01P027512 GC01M026912 GC01M027171 GC01M027543 GC01M027622 GC01M027811 GC01M026195 |
Summaries
for FGR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FGR:
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminalsites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediatingprotein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The proteinlocalizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggeredby the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression ofthis gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FGR_HUMAN, P09769Function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinaseactivity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mastcell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion andmigration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Actsdownstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Actsdownstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Dependingon the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling,phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading andadhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeletonreorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 andMAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and theproduction of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1.Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1.Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has alreadybeen phosphorylated by SYK, but not unphosphorylated HCLS1
Gene Wiki entry for FGR
|
Genomic Views
for FGR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FGR gene promoter:
p53 AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for FGR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.2-p36.1 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.2-p36.1FGR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M027938: view genomic region
(about GC identifiers)
Start:
|
27,938,575 bp from pter |
End:
|
27,961,788 bp from pter |
Size:
|
23,214 bases |
Orientation:
|
minus strand |
|
Proteins
for FGR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FGR_HUMAN, P09769 (See
protein sequence)Recommended Name: Tyrosine-protein kinase Fgr Size: 529 amino acids; 59479 Da
Subunit: Interacts with ITGB1, ITGB2, MS4A2/FCER1B, FCER1G, FCGR2A and/or FCGR2B. Interacts (via SH2 domain) with SYK(tyrosine phosphorylated). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with PTK2/FAK1.Interacts (via SH2 domain) with HCLS1 (tyrosine phosphorylated by SYK). Interacts with SIRPA and PTPNS1. Interacts(not phosphorylated on tyrosine residues) with CBL; FGR tyrosine phosphorylation promotes dissociation. Interacts withPIK3R1 and FASLG (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Cell membrane; Peripheral membraneprotein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton.Mitochondrion inner membrane (By similarity). Mitochondrion intermembrane space (By similarity). Note=Detected inmitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membraneruffles. Detected at plasma membrane lipid rafts
Secondary accessions: D3DPL7 Q9UIQ3Explore the universe of human proteins at neXtProt for FGR: NX_P09769
Post-translational modifications:
Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation1
Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2Bengagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulteriorautophosphorylation at Tyr-4121
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P09769
4/27 DME Specific Peptides for FGR (P09769) (see all 27)
FGR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001036194.1 NP_001036212.1 NP_005239.1
ENSEMBL proteins: ENSP00000363117 ENSP00000363116 ENSP00000363115 ENSP00000407670 ENSP00000445302 ENSP00000382126 Reactome Protein details: P09769
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
FGR for ontologies About GeneDecksing
FGR Antibody Products:
Assay Products for FGR: |
Protein
Domains /
Families
for FGR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FGR for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P09769ProtoNet protein and cluster: P09769 3 Blocks protein families: IPB000980 SH2 domain signature IPB001452 SH3 domain signature IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: FGR_HUMAN, P09769Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SH2 domainSimilarity: Contains 1 SH3 domain |
Function
for FGR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FGR_HUMAN, P09769Function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinaseactivity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mastcell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion andmigration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Actsdownstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Actsdownstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Dependingon the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling,phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading andadhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeletonreorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 andMAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and theproduction of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1.Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1.Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has alreadybeen phosphorylated by SYK, but not unphosphorylated HCLS1Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme regulation: Activated by autophosphorylation. Prior phosphorylation at Tyr-523 by SRC inhibits ulteriorautophosphorylation at Tyr-412. Activated by phorbol myristate acetate, phosphatidic acid and poly-Lys. Binding (viaSH2 domain) of HCLS1 that is already phosphorylated by SYK strongly increases kinase activity Genatlas biochemistry entry for FGR:Gardner-Rasheed feline sarcoma viral (c-fgr) oncogene homolog
Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGR (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGR (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for FGR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGR |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
FGR for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for FGR:
Animal Models:
Mouse knock-outs for FGR: Fgrtm1Hev Fgrtm2Hev
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Fgr):
FGR for phenotypes About GeneDecksing
|
Pathways & Interactions
for FGR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response _CCR3 signaling in eosinophils | | | 2 | Immune System | | | 3 | Cleavage of Alpha-1-Microglobulin | | | 4 | Tyrosine Kinases / Adaptors | | | 5 | Fgr may phosphorylate p38 MAPK | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for FGR
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FGR
1 
Cell Signaling Technology (CST) Pathway for FGR
1  GeneGo (Thomson Reuters) Pathway for FGR
5/14  BioSystems Pathways for FGR (see all 14)
5/9 
Reactome Pathways for FGR (see all 9)
1 
Kegg Pathway (Kegg details for FGR):
FGR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/105 Interacting proteins for FGR (P097691, 2, 3 ENSP000003631154) via UniProtKB, MINT, STRING, and/or I2D (see all 105)About this table
Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table
FGR for ontologies About GeneDecksing
|
Drugs & Compounds
for FGR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FGR for compounds About GeneDecksing
 Browse Tocris compounds for FGR
2 HMDB Compounds for FGR About this table
10/21 Novoseek chemical compound relationships for FGR gene (see all 21) About this table
Search CenterWatch for drugs/clinical trials and news about FGR
|
Transcripts
for FGR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FGR gene (3 alternative transcripts): NM_001042729.1 NM_001042747.1 NM_005248.2 Unigene Cluster for FGR: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog Hs.1422 [show with all ESTs]Unigene Representative Sequence: NM_0010427479 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374005(uc001bol.3 uc001bom.3) ENST00000469062(uc001boi.3)
ENST00000374004(uc001boj.3) ENST00000374003 ENST00000457296 ENST00000475472(uc021ojx.1)
ENST00000468038 ENST00000545953 ENST00000399173(uc001bok.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGR (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGR (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): FGR (NM_005248) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FGR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGR |
Additional cDNA sequence: AK130188.1 AK301078.1 AK304846.1 BC064382.1 M27454.1 12 DOTS entries: DT.101981047 DT.97816677 DT.97841220 DT.101981048 DT.95092467 DT.92422455 DT.121402814 DT.121402853 DT.91667423 DT.91744878 DT.99930037 DT.411384 24/127 AceView cDNA sequences (see all 127): CR604589 BM561907 CA309080 CD364431 AI090521 AW075800 AL548206 CB529879 BM454242 BM921640 CD367148 BX505943 CA448709 CB529352 CR600467 AW952205 CB529266 BX100745 CD365053 CB528674 BC064382 CD365941 BM921569 BI018346
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for FGR (see all 16) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | |
| ExUns: | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FGR
|
Expression
for FGR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FGR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGTAGCCT
About this image
See FGR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGR
SOURCE GeneReport for Unigene cluster: Hs.1422
UniProtKB/Swiss-Prot: FGR_HUMAN, P09769Tissue specificity: Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected inmonocytes and large lymphocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including FGR:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FGR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGR |
Orthologs
for FGR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FGR gene from 3/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.127262 |
Danio rerio Yes-relayed kinase (yrk) mRNA, complete more |
78.45(n) |
|
AY169369.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Src64B3 |
ring canal formation protein tyrosine kinase |
51(a) |
|
64B12 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
src-13 |
Expression: vulva, anus, mu_bod, pharyngeal
muscle, more |
45(a)
(best of 2) |
|
I(1567610-1580076) -- |
ENSEMBL Gene Tree for FGR (if available)
TreeFam Gene Tree for FGR (if available) |
Paralogs
for FGR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FGR gene
- TEC2 FRK2 LCK2 BLK2 ITK2 LYN2 TXK2 HCK2
- YES12 PTK62 SRC2 ABL12 FYN2 BMX2 ABL22 SRMS2
- BTK2
18/118 SIMAP similar genes for FGR using alignment to 5 protein entries: FGR_HUMAN (see all proteins)
(see all similar genes):c-fgr SRC BLK LYN HCK YES1
EPHA3 NCK2 ABL1 EPHA5 FRK CD74/ROS fusion
ROS1 SLC34A2/ROS fusion SLC34A2/ROS1 fusion EPHA6 FYN LCK
FGR for paralogs About GeneDecksing
|
Genomic Variants
for FGR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FGR (27938575 - 27961788 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FGR
1 CNV: 53092 | SABiosciences Cancer Mutation PCR Assays |
| 2 SABiosciences qBiomarker Copy Number PCR Arrays containing FGR: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGR |
|
Disorders
/ Diseases
for FGR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FGR for disorders About GeneDecksing
OMIM gene information: 164940
OMIM disorders: --
UniProtKB/Swiss-Prot: FGR_HUMAN, P09769
Note=Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cellproliferation
20/29  diseases for FGR (see all 29): About MalaCardspre-eclampsia severe pre-eclampsia wiskott-aldrich syndrome sarcoma
placental insufficiency eclampsia chronic myeloid leukemia myeloid leukemia
thrombophilia myelodysplastic syndrome polycythemia periodontitis
lymphoblastic leukemia periodontal disease gout breast cancer
rhabdomyosarcoma colon carcinoma ovarian carcinoma leukemia
2 diseases from the University of Copenhagen DISEASES database for FGR:Lung cancer Leukemia 6 Novoseek disease relationships for FGR gene About this table
Human Genome Epidemiology (HuGE) Navigator: FGR (10 documents)
Tumor Gene Database (TGDB): FGR
Export disorders for FGR gene to outside databases
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Publications
for FGR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FGR gene, integrated from 9 sources (see all 209):
(articles sorted by number of sources associating them with FGR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils. (PubMed id 12435267)1, 2, 9 Melander F....Dib K. (2003)
- Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites. (PubMed id 1690869)1, 2, 9 Patel M.... Brickell P.M. (1990)
- Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation. (PubMed id 17164290)1, 2, 9 Zuccato E....Griffiths G.M. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase. (PubMed id 10739672)1, 2 Axelsson L....Andersson T. (2000)
- Activation of SRC family kinases in human neutrophils. Evidence that p58C-FGR and p53/56LYN redistributed to a Triton X-100-insoluble cytoskeletal fraction, also enriched in the caveolar protein caveolin, display an enhanced kinase activity. (PubMed id 8603737)1, 2 Yan S.R.... Berton G. (1996)
- Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils. (PubMed id 7519620)1, 2 Berton G....Sorio C. (1994)
- Association of immunoglobulin G Fc receptor II with S rc-like protein-tyrosine kinase Fgr in neutrophils. (PubMed id 8327512)1, 2 Hamada F....Toyoshima K. (1993)
- Specific expression of human c-fgr in natural immunity effector cells. (PubMed id 2181286)1, 2 Inoue K.... Toyoshima K. (1990)
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External Searches for FGR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
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Genome Databases showing FGR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing FGR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FGR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for FGR gene:
Search GeneIP for patents involving FGR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FGR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for FGR | | OriGene shRNA RFP for FGR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGR | | | OriGene Protein Over-expression Lysate for FGR | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FGR | | OriGene 3'-UTR Clone for FGR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FGR | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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