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FGL2 Gene

protein-coding   GIFtS: 56
GCID: GC07M076822

Fibrinogen-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibrinogen-Like 21 2
Fibrinogen-Like Protein 22 3
pT492 3
T492
fibroleukin2

External Ids:    HGNC: 36961   Entrez Gene: 108752   Ensembl: ENSG000001279517   OMIM: 6053515   UniProtKB: Q143143   

Export aliases for FGL2 gene to outside databases

Previous GC identifers: GC07M075361 GC07M076423 GC07M076437 GC07M076470 GC07M076662 GC07M071425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGL2 Gene:
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of
fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The
encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may
play a role in physiologic functions at mucosal sites. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGL2 Gene:
FGL2 (fibrinogen-like 2) is a protein-coding gene. Diseases associated with FGL2 include severe acute respiratory syndrome, and acute liver failure. An important paralog of this gene is ANGPT4.

UniProtKB/Swiss-Prot: FGL2_HUMAN, Q14314
Function: May play a role in physiologic lymphocyte functions at mucosal sites

Gene Wiki entry for FGL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGL2 gene promoter:
         STAT1   AML1a   FOXF2   Brachyury   Olf-1   STAT1beta   IRF-1   STAT1alpha   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGL2 promoter sequence
   Search Chromatin IP Primers for FGL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

FGL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGL2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M076822:  view genomic region     (about GC identifiers)

Start:
76,822,688 bp from pter      End:
76,829,150 bp from pter
Size:
6,463 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 76,155,751-76,162,213     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FGL2_HUMAN, Q14314 (See protein sequence)
Recommended Name: Fibroleukin precursor  
Size: 439 amino acids; 50229 Da
Subunit: Homotetramer; disulfide-linked

Explore the universe of human proteins at neXtProt for FGL2: NX_Q14314

Explore proteomics data for FGL2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn25, Asn179, Asn235, Asn263, Asn336

  • See FGL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006673.1  
    ENSEMBL proteins: 
     ENSP00000248598  

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    Cloud-Clone Corp. CLIAs for FGL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FIBC: Fibrinogen C domain containing

    4 InterPro protein domains:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry Q14314

    ProtoNet protein and cluster: Q14314

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: FGL2_HUMAN, Q14314
    Similarity: Contains 1 fibrinogen C-terminal domain


    FGL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGL2_HUMAN, Q14314
    Function: May play a role in physiologic lymphocyte functions at mucosal sites

         Genatlas biochemistry entry for FGL2:
    fibrinogen-like 2,expressed in T lymphocytes

    Phenotypes:
         1 GenomeRNAi human phenotype for FGL2:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fgl2):
     cardiovascular system  homeostasis/metabolism  immune system  mortality/aging 

    FGL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fgl2tm1Stsm for FGL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGL2
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    miRNA
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    miRTarBase miRNAs that target FGL2:
    hsa-mir-26b-5p (MIRT030088), hsa-mir-335-5p (MIRT018781)

    Block miRNA regulation of human, mouse, rat FGL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGL2 (see all 18):
    hsa-miR-607 hsa-miR-16-2* hsa-miR-199b-3p hsa-miR-4328 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-3692 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidFGL2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGL2_HUMAN, Q14314: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005577fibrinogen complex TAS7642106
    GO:0070062extracellular vesicular exosome IDA19056867

    FGL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FGL2
    Interactions:

        Search GeneGlobe Interaction Network for FGL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for FGL2 (Q143143 ENSP000002485984) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF6Q166303I2D: score=1 
    FGAENSP000003063614STRING: ENSP00000306361
    FGBENSP000003060994STRING: ENSP00000306099
    FGGENSP000003368294STRING: ENSP00000336829
    FN1ENSP000003468394STRING: ENSP00000346839
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGL2

    3 Novoseek inferred chemical compound relationships for FGL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hirudin 59.3 2 17627227 (1), 18955143 (1)
    serine 17.7 3 11994472 (3)
    fibrinogen 17.1 2 15268797 (1), 9647217 (1)



    FGL2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FGL2 gene: 
    NM_006682.2  

    Unigene Cluster for FGL2:

    Fibrinogen-like 2
    Hs.520989  [show with all ESTs]
    Unigene Representative Sequence: NM_006682
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248598(uc003ugb.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FGL2 (see all 18):
    hsa-miR-607 hsa-miR-16-2* hsa-miR-199b-3p hsa-miR-4328 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-3692 hsa-miR-3916
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      QuantiTect SYBR Green Assays in human, mouse, rat FGL2
      QuantiFast Probe-based Assays in human, mouse, rat FGL2

    Additional mRNA sequence: 

    AK222999.1 AK310921.1 AK312672.1 BC017813.1 BC033820.1 BC073986.1 CR626993.1 Z36531.1 

    9 DOTS entries:

    DT.100763829  DT.411270  DT.99966380  DT.121124933  DT.121124849  DT.100763827  DT.100690071  DT.425175 
    DT.91734133 

    Selected AceView cDNA sequences (see all 89):

    AL574274 BU929217 CD369260 BP348913 BM724154 BC033820 AW611535 BC017813 
    AW204815 CA407168 BC073986 CA394164 CR610336 CD671192 AU136637 AW294447 
    H64776 AL550407 AI767076 BI760455 AI796353 BF433325 BX095475 AW316574 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FGL2 Expression
    About this image


    FGL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Dermis (Integumentary System)    fully expand to see all 3 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Kidney (Urinary System)
             S-shaped Body
    FGL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520989

    UniProtKB/Swiss-Prot: FGL2_HUMAN, Q14314
    Tissue specificity: Constitutively expressed in cytotoxic T-cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGL2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgl21 , 5 fibrinogen-like protein 21, 5 80.51(n)1
    79.12(a)1
      5 (9.83 cM)5
    141901  NM_008013.41  NP_032039.21 
     213726425 
    chicken
    (Gallus gallus)
    Aves FGL21 fibrinogen-like 2 69.55(n)
    66.82(a)
      768821  NM_001079486.1  NP_001072954.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGL26
    fibrinogen-like 2
    65(a)
    1 ↔ 1
    5(95123256-95129607)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.236842 Xenopus laevis transcribed sequence with moderate similarity more 79.7(n)    BQ398999.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgl21 fibrinogen-like 2 61.69(n)
    59.95(a)
      565637  NM_001025539.2  NP_001020710.1 


    ENSEMBL Gene Tree for FGL2 (if available)
    TreeFam Gene Tree for FGL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGL2 gene
    ANGPT42  FGG2  FIBCD12  ANGPTL62  FCN32  ANGPTL22  FCN22  FCN12  
    ANGPT12  ANGPTL12  ANGPTL72  FGB2  ANGPT22  MFAP42  FGL12  
    6 SIMAP similar genes for FGL2 using alignment to 2 protein entries:     FGL2_HUMAN (see all proteins):
    FCN3    ANGPTL7    LFIRE1    FGL1    ANGPT2    ANGPT1

    FGL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for FGL2    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20757611,2,4
    ----see VAR_0130662 mis40--------

    HapMap Linkage Disequilibrium report for FGL2 (76822688 - 76829150 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FGL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34102CNV Loss18971310
    nsv526097CNV Gain19592680
    nsv888508CNV Gain21882294
    nsv428174CNV Gain18775914
    essv14753CNV CNV17122850
    dgv2109e1CNV Complex17122850
    dgv2104e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605351    OMIM disorders: --

    13 diseases for FGL2:    
    About MalaCards
    severe acute respiratory syndrome    acute liver failure    viral hepatitis    endocarditis
    hepatitis b    nasopharyngitis    hepatitis    liver disease
    periodontitis    endotheliitis    malaria    hepatocellular carcinoma
    cerebritis

    1 disease from the University of Copenhagen DISEASES database for FGL2:
    Hepatitis

    FGL2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FGL2 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis fulminant 74.1 1 12752447 (1)
    hepatic necrosis 67 1 12594208 (1)
    viral hepatitis 66.7 15 12840059 (2), 16437596 (2), 18801734 (1), 15100314 (1) (see all 6)
    hepatic failure fulminant 58.5 9 19785959 (3), 12594208 (1)
    hepatitis b chronic 58.1 3 12840059 (2), 16437596 (1)
    hepatitis 54.4 6 12840059 (1), 19785959 (1), 12594208 (1), 15268797 (1) (see all 5)
    thrombosis 28.6 4 15100314 (4)
    liver diseases 24.7 1 12594208 (1)
    hepatitis b 22.6 11 16437596 (3), 18801734 (1), 15268797 (1)
    necrosis 22.3 3 10429765 (1), 19785959 (1)

    Genetic Association Database (GAD): FGL2
    Human Genome Epidemiology (HuGE) Navigator: FGL2 (2 documents)

    Export disorders for FGL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGL2 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with FGL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein. (PubMed id 7642106)1, 2, 3 Ruegg C. and Pytela R. (Gene 1995)
    2. Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. (PubMed id 9647217)1, 2, 9 Marazzi S.... Ruegg C. (J. Immunol. 1998)
    3. Candidate genes associated with susceptibility for SARS-coronavirus. (PubMed id 19590927)1, 4 Hsieh Y.H....Ho M.S. (Bull. Math. Biol. 2010)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    5. Large-scale investigation of genomic markers for severe periodontitis. (PubMed id 15490304)1, 4 Suzuki A....Kamoi K. (Odontology 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The FGL2/fibroleukin prothrombinase is involved in alveolar macrophage activation in COPD through the MAPK pathway. (PubMed id 20438701)1, 9 Liu Y....Ning Q. (Biochem. Biophys. Res. Commun. 2010)
    8. Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejection. (PubMed id 15905589)1, 9 Ning Q....Luo X. (J. Immunol. 2005)
    9. Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B. (PubMed id 16437596)1, 9 Zhu C.L....Ning Q. (World J. Gastroenterol. 2005)
    10. Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: a novel human procoagulant. (PubMed id 11170750)1, 9 Yuwaraj S....Levy G.A. (Genomics 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10875 HGNC: 3696 AceView: FGL2 Ensembl:ENSG00000127951 euGenes: HUgn10875
    ECgene: FGL2 H-InvDB: FGL2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGL2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/fgl2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGL2 gene:
    Search GeneIP for patents involving FGL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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