Aliases for FGL2 Gene
Aliases for FGL2 Gene
External Ids for FGL2 Gene
- HGNC: 3696
- Entrez Gene: 10875
- Ensembl: ENSG00000127951
- OMIM: 605351
- UniProtKB: Q14314
Previous GeneCards Identifiers for FGL2 Gene
- GC07M075361
- GC07M076423
- GC07M076437
- GC07M076470
- GC07M076662
- GC07M076822
- GC07M071425
Summaries for FGL2 Gene
-
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGL2 Gene
FGL2 (Fibrinogen Like 2) is a Protein Coding gene. Diseases associated with FGL2 include Viral Hepatitis and Hepatitis B. Among its related pathways are Innate Immune System. An important paralog of this gene is ANGPT2.
UniProtKB/Swiss-Prot for FGL2 Gene
-
May play a role in physiologic lymphocyte functions at mucosal sites.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGL2 Gene
Genomics for FGL2 Gene
Regulatory Elements for FGL2 Gene
Enhancers for FGL2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G077245 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 11.7 | -46.0 | -46029 | 1.4 | ELF3 TBP MLX ARID4B DMAP1 THRB RAD21 RARA YY1 TCF12 | FGL2 CCDC146 LOC105375359 GC07M077229 |
| GH07G077269 | 0.9 | Ensembl ENCODE dbSUPER | 16.2 | -70.3 | -70335 | 1.5 | ETV6 | FGL2 CCDC146 PIR56172 LOC102723791 |
| GH07G077222 | 0.6 | Ensembl ENCODE | 23.8 | -23.2 | -23162 | 1.2 | TFAP4 | FGL2 ENSG00000250990 CCDC146 GC07M077229 |
| GH07G077154 | 1.2 | Ensembl ENCODE dbSUPER | 11.5 | +43.3 | 43298 | 3.4 | HDGF CTCF RFX1 MTA2 NR2F1 TRIM22 BMI1 CEBPG DPF2 ZBTB40 | FGL2 CCDC146 ENSG00000213542 SPDYE16 ZP3 GC07P077132 GC07M077197 |
| GH07G077252 | 0.5 | ENCODE dbSUPER | 22.5 | -54.5 | -54478 | 3.0 | FGL2 CCDC146 ENSG00000250990 LOC105375359 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FGL2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FGL2 gene promoter:
Regulatory Element Products
Genomic Location for FGL2 Gene
- Chromosome:
- 7
- Start:
- 77,193,371 bp from pter
- End:
- 77,199,848 bp from pter
- Size:
- 6,478 bases
- Orientation:
- Minus strand
Genomic View for FGL2 Gene
Genes around FGL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q11.23 by Ensembl
- 7q11.23 by Entrez Gene
- 7q11.23 by HGNC
FGL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGL2 Gene
Proteins for FGL2 Gene
-
Protein details for FGL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14314-FGL2_HUMAN
- Recommended name:
- Fibroleukin
- Protein Accession:
- Q14314
Protein attributes for FGL2 Gene
- Size:
- 439 amino acids
- Molecular mass:
- 50229 Da
- Quaternary structure:
-
- Homotetramer; disulfide-linked.
Protein Expression for FGL2 Gene
Post-translational modifications for FGL2 Gene
Other Protein References for FGL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FGL2 (FGL2)
-
Custom Antibody ServicesOriGene Antibodies for FGL2
- Novus Biologicals Antibodies for FGL2
-
Abcam antibodies for FGL2
-
Cloud-Clone Corp. Antibodies for FGL2
- Invitrogen Antibodies for FGL2
- antibodies-online Antibodies for FGL2: See all 81
- GeneTex FGL2 antibody for FGL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGL2
Protein Products
-
OriGene Purified Proteins for FGL2
- Search Origene for MassSpec and Protein Over-expression Lysates for FGL2
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-
Cloud-Clone Corp. Proteins for FGL2
- antibodies-online Proteins for FGL2: See all 16
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FGL2
-
Abcam proteins for FGL2
No data available for DME Specific Peptides for FGL2 Gene
Domains & Families for FGL2 Gene
Gene Families for FGL2 Gene
Protein Domains for FGL2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FGL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FGL2 Gene
Function for FGL2 Gene
Molecular function for FGL2 Gene
- GENATLAS Biochemistry:
- fibrinogen-like 2,expressed in T lymphocytes
- UniProtKB/Swiss-Prot Function:
- May play a role in physiologic lymphocyte functions at mucosal sites.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008233 | peptidase activity | IEA | -- |
Phenotypes for FGL2 Gene
- MGI mutant phenotypes for FGL2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FGL2:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for FGL2 gene
-
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- Search ViGene Biosciences for FGL2
CRISPR Products
-
OriGene CRISPR knockouts for FGL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGL2
- GenScript: Design CRISPR guide RNA sequences for FGL2
miRNA for FGL2 Gene
- miRTarBase miRNAs that target FGL2
miRNA Products
- Search ViGene Biosciences for FGL2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FGL2
- Browse OriGene Inhibitory RNA Products For FGL2
-
ViGene Biosciences ready-to-package AAV shRNAs for FGL2 gene
Clone Products
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Cell Line Products
-
Horizon Cell Lines for FGL2
-
ViGene Biosciences adenoviral particle packaged cDNA for FGL2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FGL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGL2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGL2 Gene
Localization for FGL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGL2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 2 |
| mitochondrion | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005577 | fibrinogen complex | TAS | 7642106 |
| GO:0070062 | extracellular exosome | IDA | 19056867 |
| GO:1904813 | ficolin-1-rich granule lumen | TAS | -- |
Pathways & Interactions for FGL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
Pathways by source for FGL2 Gene
3 Reactome pathways for FGL2 Gene
Interacting Proteins for FGL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for FGL2 Gene
Transcripts for FGL2 Gene
mRNA/cDNA for FGL2 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (89) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FGL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGL2
- GenScript: Design CRISPR guide RNA sequences for FGL2
miRNA Products
- Search ViGene Biosciences for FGL2
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for FGL2 gene
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Flow Cytometry Products
Expression for FGL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
- T Helper Cells Thymus
- Hematopoietic Bone Marrow
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Dermal Fibroblasts Dorsal Dermis
- Brain (Nervous System)
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
- Dermal Fibroblasts Dorsal Dermis
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Liver (Hepatobiliary System)
- Mature Mesothelial Cells Liver Lobule
- Kidney (Urinary System)
- Neural Crest (Gastrulation Derivatives)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for FGL2 Gene
This gene is overexpressed in Artery - Aorta (x8.3), Esophagus - Gastroesophageal Junction (x6.6), Esophagus - Muscularis (x5.4), and Whole Blood (x5.2).
This gene is overexpressed in Plasma (21.8), Serum (12.4), and Spleen (9.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGL2 Gene:
FGL2SOURCE GeneReport for Unigene cluster for FGL2 Gene:
Hs.520989mRNA Expression by UniProt/SwissProt for FGL2 Gene:
Q14314-FGL2_HUMAN
Tissue specificity:
Constitutively expressed in cytotoxic T-cells.
Evidence on tissue expression from TISSUES for FGL2 Gene
- Blood(4.6)
- Liver(4.6)
- Intestine(4.4)
- Bone marrow(4.2)
- Pancreas(4.1)
- Spleen(2.9)
- Nervous system(2.9)
- Heart(2.5)
- Kidney(2.5)
- Lymph node(2.3)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for FGL2
-
OriGene qPCR primer pairs and template standards for FGL2
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGL2 Gene
Orthologs for FGL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGL2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FGL2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FGL2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fgl2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fgl2 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FGL2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGL2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FGL2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgl2 34 |
|
||
| Str.15307 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23684 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgl2 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG8642 36 |
|
|
|
| CG1889 36 |
|
|
|||
| CG1791 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CS-FIBRINOGEN-LIKE 35 |
|
OneToOne |
- Species where no ortholog for FGL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGL2 Gene
Variants for FGL2 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000548755 | -- | 77,197,579(+) | GCACA(G/T)GCTTC | intron-variant | |
| rs1001511048 | -- | 77,198,894(+) | AACAT(C/T)AAGAA | intron-variant | |
| rs1001543507 | -- | 77,199,281(+) | ACATA(A/C)TTTTC | intron-variant, reference, missense | |
| rs1001578494 | -- | 77,193,714(+) | TAGGT(A/G)AATCA | intron-variant, utr-variant-3-prime | |
| rs1001924611 | -- | 77,193,419(+) | TAGAT(A/G)TGATA | intron-variant, utr-variant-3-prime |
Residual Variation Intolerance Score:
26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.66;
72.81% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FGL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FGL2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGL2 Gene
Disorders for FGL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| viral hepatitis |
|
|
| hepatitis b |
|
Search FGL2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FGL2
No data available for UniProtKB/Swiss-Prot and Genatlas for FGL2 Gene
Publications for FGL2 Gene
- Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. (PMID: 9647217) Marazzi S. … Ruegg C. (J. Immunol. 1998) 3 4 22 64
- Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein. (PMID: 7642106) Ruegg C. … Pytela R. (Gene 1995) 2 3 4 64
- The FGL2/fibroleukin prothrombinase is involved in alveolar macrophage activation in COPD through the MAPK pathway. (PMID: 20438701) Liu Y. … Ning Q. (Biochem. Biophys. Res. Commun. 2010) 3 22 64
- Candidate genes associated with susceptibility for SARS-coronavirus. (PMID: 19590927) Hsieh Y.H. … Ho M.S. (Bull. Math. Biol. 2010) 3 46 64
- Hepatitis B virus-induced hFGL2 transcription is dependent on c-Ets-2 and MAPK signal pathway. (PMID: 18801734) Han M. … Ning Q. (J. Biol. Chem. 2008) 3 22 64
Products for FGL2 Gene
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- Custom Antibody ServicesOriGene Antibodies for FGL2
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- Cloud-Clone Corp. Antibodies for FGL2
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- antibodies-online Antibodies for FGL2: See all 81
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- antibodies-online Proteins for FGL2: See all 16
- Search antibodies-online for peptides
- GeneTex FGL2 antibody for FGL2
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- ViGene Biosciences adenoviral particle packaged cDNA for FGL2 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for FGL2
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- VectorBuilder custom plasmid, inducible vectors for FGL2
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FGL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (132) NINDS
- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer