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Aliases for FGL1 Gene

Aliases for FGL1 Gene

  • Fibrinogen Like 1 2 3 5
  • Hepatocyte-Derived Fibrinogen-Related Protein 1 3 4
  • Liver Fibrinogen-Related Protein 1 3 4
  • Hepassocin 3 4
  • LFIRE-1 3 4
  • HFREP1 3 4
  • HP-041 3 4
  • Hepatocellular Carcinoma-Related Sequence 3
  • Fibrinogen-Like 1 3
  • HFREP-1 4
  • LFIRE1 3

External Ids for FGL1 Gene

Previous GeneCards Identifiers for FGL1 Gene

  • GC08M017602
  • GC08M017789
  • GC08M017732
  • GC08M017766
  • GC08M016265
  • GC08M017721

Summaries for FGL1 Gene

Entrez Gene Summary for FGL1 Gene

  • Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGL1 Gene

FGL1 (Fibrinogen Like 1) is a Protein Coding gene. Diseases associated with FGL1 include Hepatocellular Carcinoma. An important paralog of this gene is FGB.

UniProtKB/Swiss-Prot for FGL1 Gene

  • Has hepatocyte mitogenic activity.

Gene Wiki entry for FGL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGL1 Gene

Genomics for FGL1 Gene

Regulatory Elements for FGL1 Gene

Enhancers for FGL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FGL1 on UCSC Golden Path with GeneCards custom track

Promoters for FGL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FGL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FGL1 Gene

17,864,380 bp from pter
17,910,365 bp from pter
45,986 bases
Minus strand

Genomic View for FGL1 Gene

Genes around FGL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGL1 Gene

Proteins for FGL1 Gene

  • Protein details for FGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibrinogen-like protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NKU4
    • Q4PJH9
    • Q53YF1
    • Q8NG32
    • Q96KW6
    • Q96QM6

    Protein attributes for FGL1 Gene

    312 amino acids
    Molecular mass:
    36379 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FGL1 Gene

Proteomics data for FGL1 Gene at MOPED

Post-translational modifications for FGL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for FGL1 Gene

Domains & Families for FGL1 Gene

Gene Families for FGL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibrinogen C-terminal domain.
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with FGL1: view

Function for FGL1 Gene

Molecular function for FGL1 Gene

GENATLAS Biochemistry:
fibrinogen related gene overexpressed in hepatocellular carcinoma
UniProtKB/Swiss-Prot Function:
Has hepatocyte mitogenic activity.
genes like me logo Genes that share phenotypes with FGL1: view

Animal Models for FGL1 Gene

MGI Knock Outs for FGL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGL1 Gene

Localization for FGL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGL1 Gene


Subcellular locations from

Jensen Localization Image for FGL1 Gene COMPARTMENTS Subcellular localization image for FGL1 gene
Compartment Confidence
extracellular 5
mitochondrion 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FGL1: view

Pathways & Interactions for FGL1 Gene

SuperPathways for FGL1 Gene

No Data Available

Interacting Proteins for FGL1 Gene

Gene Ontology (GO) - Biological Process for FGL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FGL1 Gene

Drugs & Compounds for FGL1 Gene

(1) Additional Compounds for FGL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGL1: view

Transcripts for FGL1 Gene

Unigene Clusters for FGL1 Gene

Fibrinogen-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGL1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - - - -
SP10: - - - -
SP12: -

Relevant External Links for FGL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGL1 Gene

mRNA expression in normal human tissues for FGL1 Gene

mRNA differential expression in normal tissues according to GTEx for FGL1 Gene

This gene is overexpressed in Liver (x47.8) and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for FGL1 Gene

This gene is overexpressed in Plasma (45.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FGL1 Gene

SOURCE GeneReport for Unigene cluster for FGL1 Gene Hs.491143

mRNA Expression by UniProt/SwissProt for FGL1 Gene

Tissue specificity: Liver specific.
genes like me logo Genes that share expression patterns with FGL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for FGL1 Gene

Orthologs for FGL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FGL1 35
  • 89.42 (n)
  • 88.78 (a)
FGL1 36
  • 89 (a)
(Canis familiaris)
Mammalia FGL1 35
  • 90.4 (n)
  • 88.67 (a)
FGL1 36
  • 89 (a)
(Mus musculus)
Mammalia Fgl1 35
  • 84.4 (n)
  • 82.05 (a)
Fgl1 16
Fgl1 36
  • 82 (a)
(Pan troglodytes)
Mammalia FGL1 35
  • 99.25 (n)
  • 98.08 (a)
FGL1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Fgl1 35
  • 81.4 (n)
  • 79.46 (a)
(Monodelphis domestica)
Mammalia FGL1 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia FGL1 36
  • 70 (a)
(Gallus gallus)
Aves FGL1 35
  • 72.57 (n)
  • 70.49 (a)
FGL1 36
  • 67 (a)
(Anolis carolinensis)
Reptilia FGL1 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgl1 35
  • 67.32 (n)
  • 66.45 (a)
(Danio rerio)
Actinopterygii LOC100003029 35
  • 61.95 (n)
  • 57.89 (a)
FGL1 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5550 37
  • 39 (a)
Species with no ortholog for FGL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGL1 Gene

Gene Tree for FGL1 (if available)
Gene Tree for FGL1 (if available)

Paralogs for FGL1 Gene

Paralogs for FGL1 Gene

genes like me logo Genes that share paralogs with FGL1: view

Variants for FGL1 Gene

Sequence variations from dbSNP and Humsavar for FGL1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs484373 - 17,885,511(-) TCTGA(C/T)AATGG reference, missense
rs3739406 - 17,882,029(-) CTGTC(A/G)TTGAT reference, missense
rs2653406 - 17,874,452(-) GAGCC(C/T)AGCAG reference, missense
rs34019703 - 17,874,435(-) CTGTT(C/T)ATTGT reference, missense
rs34239530 - 17,874,405(-) GATGG(A/T)CTGTA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FGL1 Gene

Variant ID Type Subtype PubMed ID
nsv831250 CNV Loss 17160897
nsv890560 CNV Loss 21882294
nsv890561 CNV Loss 21882294
nsv890562 CNV Gain 21882294
nsv890563 CNV Loss 21882294
nsv890564 CNV Loss 21882294
nsv890565 CNV Loss 21882294
dgv7738n71 CNV Loss 21882294
nsv890568 CNV Gain 21882294
dgv7739n71 CNV Loss 21882294
nsv890571 CNV Loss 21882294
nsv890572 CNV Gain 21882294
esv1981831 CNV Deletion 18987734
esv2736697 CNV Deletion 23290073
esv3690 CNV Deletion 18987735
esv999314 CNV Deletion 20482838
nsv397275 CNV Loss 16902084
esv2736698 CNV Deletion 23290073
esv1091529 CNV Deletion 17803354
nsv890573 CNV Gain 21882294
nsv890574 CNV Loss 21882294
esv24172 CNV Loss 19812545
nsv890575 CNV Loss 21882294
nsv890576 CNV Loss 21882294
dgv7740n71 CNV Loss 21882294
nsv890578 CNV Loss 21882294
esv1120408 CNV Insertion 17803354
esv1012336 CNV Insertion 17803354
esv2657492 CNV Deletion 23128226
dgv7741n71 CNV Loss 21882294
dgv7742n71 CNV Gain 21882294
dgv7743n71 CNV Loss 21882294
nsv890586 CNV Gain 21882294
dgv7744n71 CNV Loss 21882294
dgv7745n71 CNV Gain 21882294
esv24086 CNV Loss 19812545
esv2664484 CNV Deletion 23128226
esv2736699 CNV Deletion 23290073
nsv824560 CNV Loss 20364138
esv2421689 CNV Deletion 20811451

Variation tolerance for FGL1 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.94; 89.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGL1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGL1 Gene

Disorders for FGL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FGL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search FGL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FGL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGL1 Gene

Publications for FGL1 Gene

  1. Molecular cloning and initial characterization of a novel fibrinogen- related gene, HFREP-1. (PMID: 8390249) Yamamoto T. … Hirohashi S. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 23 67
  2. Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma. (PMID: 19304666) Yu H.T. … Yang X.M. (J. Biol. Chem. 2009) 3 23
  3. Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant. (PMID: 18039467) Liu Z. … Ukomadu C. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Hepatocyte-derived fibrinogen-related protein-1 is associated with the fibrin matrix of a plasma clot. (PMID: 16996032) Rijken D.C. … Leebeek F.W. (Biochem. Biophys. Res. Commun. 2006) 3 23
  5. LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma. (PMID: 14981537) Yan J. … Xu Y. (Oncogene 2004) 3 23

Products for FGL1 Gene

Sources for FGL1 Gene