Aliases for FGL1 Gene
Aliases for FGL1 Gene
External Ids for FGL1 Gene
- HGNC: 3695
- Entrez Gene: 2267
- Ensembl: ENSG00000104760
- OMIM: 605776
- UniProtKB: Q08830
Previous GeneCards Identifiers for FGL1 Gene
- GC08M017602
- GC08M017789
- GC08M017732
- GC08M017766
- GC08M016265
- GC08M017721
Summaries for FGL1 Gene
-
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGL1 Gene
FGL1 (Fibrinogen Like 1) is a Protein Coding gene. Diseases associated with FGL1 include Hepatocellular Carcinoma and Basal Laminar Drusen. An important paralog of this gene is FGL2.
UniProtKB/Swiss-Prot for FGL1 Gene
-
Has hepatocyte mitogenic activity.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGL1 Gene
Genomics for FGL1 Gene
Regulatory Elements for FGL1 Gene
- Transcription factor binding sites by QIAGEN in the FGL1 gene promoter:
Regulatory Element Products
Genomic Location for FGL1 Gene
- Chromosome:
- 8
- Start:
- 17,864,380 bp from pter
- End:
- 17,910,365 bp from pter
- Size:
- 45,986 bases
- Orientation:
- Minus strand
Genomic View for FGL1 Gene
- Cytogenetic band:
-
- 8p22 by Ensembl
- 8p22 by Entrez Gene
- 8p22 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGL1 Gene
Proteins for FGL1 Gene
-
Protein details for FGL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q08830-FGL1_HUMAN
- Recommended name:
- Fibrinogen-like protein 1
- Protein Accession:
- Q08830
- A6NKU4
- Q4PJH9
- Q53YF1
- Q8NG32
- Q96KW6
- Q96QM6
Protein attributes for FGL1 Gene
- Size:
- 312 amino acids
- Molecular mass:
- 36379 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for FGL1 Gene
Post-translational modifications for FGL1 Gene
Other Protein References for FGL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FGL1 (Hepassocin)
-
Custom Antibody ServicesOriGene Antibodies for FGL1
- Novus Biologicals Antibodies for FGL1
-
Cloud-Clone Corp. Antibodies for FGL1
- Invitrogen Antibodies for FGL1
- antibodies-online Antibodies for FGL1: See all 105
- GeneTex FGL1 antibody for FGL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGL1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FGL1
- Origene Custom Protein Services for FGL1
-
Cloud-Clone Corp. Proteins for FGL1
- antibodies-online Proteins for FGL1: See all 17
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FGL1
No data available for DME Specific Peptides for FGL1 Gene
Domains & Families for FGL1 Gene
Gene Families for FGL1 Gene
Protein Domains for FGL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FGL1 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FGL1 Gene
Function for FGL1 Gene
Molecular function for FGL1 Gene
- GENATLAS Biochemistry:
- fibrinogen related gene overexpressed in hepatocellular carcinoma
- UniProtKB/Swiss-Prot Function:
- Has hepatocyte mitogenic activity.
Phenotypes for FGL1 Gene
- MGI mutant phenotypes for FGL1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FGL1:
Animal Model Products
-
Taconic Biosciences Mouse Models for FGL1
-
ViGene Biosciences lentiviral particle packaged cDNA for FGL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGL1 gene
- Search ViGene Biosciences for FGL1
CRISPR Products
-
OriGene CRISPR knockouts for FGL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGL1
- GenScript: Design CRISPR guide RNA sequences for FGL1
miRNA Products
- Search ViGene Biosciences for FGL1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FGL1
- Browse OriGene Inhibitory RNA Products For FGL1
-
ViGene Biosciences ready-to-package AAV shRNAs for FGL1 gene
Clone Products
- Sino Biological Human cDNA Clone for FGL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FGL1
-
ViGene Biosciences adenoviral particle packaged cDNA for FGL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FGL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGL1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGL1 Gene
Localization for FGL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGL1 Gene
- Secreted.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005577 | fibrinogen complex | TAS | 8390249 |
| GO:0070062 | extracellular exosome | IDA | 23376485 |
Transcripts for FGL1 Gene
mRNA/cDNA for FGL1 Gene
- (6) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (198) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FGL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGL1
- GenScript: Design CRISPR guide RNA sequences for FGL1
miRNA Products
- Search ViGene Biosciences for FGL1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FGL1
- Browse OriGene Inhibitory RNA Products For FGL1
-
ViGene Biosciences ready-to-package AAV shRNAs for FGL1 gene
Clone Products
- Sino Biological Human cDNA Clone for FGL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
Expression for FGL1 Gene
mRNA differential expression in normal tissues according to GTEx for FGL1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FGL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGL1 Gene:
FGL1SOURCE GeneReport for Unigene cluster for FGL1 Gene:
Hs.491143mRNA Expression by UniProt/SwissProt for FGL1 Gene:
Q08830-FGL1_HUMANEvidence on tissue expression from TISSUES for FGL1 Gene
- Liver(4.9)
- Pancreas(2.3)
Primer Products
-
OriGene qPCR primer pairs for FGL1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGL1 Gene
Orthologs for FGL1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGL1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FGL1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FGL1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fgl1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fgl1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FGL1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FGL1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGL1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FGL1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgl1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | FGL1 35 |
|
OneToOne | |
| LOC100003029 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5550 36 |
|
|
- Species where no ortholog for FGL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGL1 Gene
Paralogs for FGL1 Gene
(25) SIMAP similar genes for FGL1 Gene using alignment to 2 proteins:
Variants for FGL1 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000009960 | -- | 17,879,857(+) | ATTAG(C/G)TGCCC | intron-variant | |
| rs1000085027 | -- | 17,871,916(+) | AATAC(A/G)TTTGA | intron-variant | |
| rs1000171537 | -- | 17,873,492(+) | GATTT(C/G)TGAGA | intron-variant | |
| rs1000219416 | -- | 17,896,314(+) | CTACT(A/G)GACTT | upstream-variant-2KB, utr-variant-5-prime | |
| rs1000237583 | -- | 17,868,244(+) | ATATA(C/T)ATGCT | intron-variant |
Relevant External Links for FGL1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGL1 Gene
Disorders for FGL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatocellular carcinoma |
|
|
| basal laminar drusen |
|
|
Relevant External Links for FGL1
No data available for UniProtKB/Swiss-Prot and Genatlas for FGL1 Gene
Publications for FGL1 Gene
- Molecular cloning and initial characterization of a novel fibrinogen- related gene, HFREP-1. (PMID: 8390249) Yamamoto T. … Hirohashi S. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 22 64
- Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity. (PMID: 11470158) Hara H. … Shiokawa K. (Biochim. Biophys. Acta 2001) 3 4 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
Products for FGL1 Gene
- R&D Systems Antibodies for FGL1 (Hepassocin)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for FGL1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for FGL1
- Origene Custom Protein Services for FGL1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FGL1
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- OriGene qPCR primer pairs for FGL1
- OriGene CRISPR knockouts for FGL1
- OriGene ORF clones in human for FGL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for FGL1 in any vector
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- GenScript: Design CRISPR guide RNA sequences for FGL1
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- Sino Biological Human cDNA Clone for FGL1
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FGL1
- Novus Biologicals proteins and lysates for FGL1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for FGL1
- Cloud-Clone Corp. Proteins for FGL1
- Cloud-Clone Corp Assay Kits for FGL1
- Taconic Biosciences Mouse Models for FGL1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for FGL1: See all 105
- antibodies-online Kits for FGL1: See all 35
- antibodies-online Proteins for FGL1: See all 17
- Search antibodies-online for peptides
- GeneTex FGL1 antibody for FGL1
- Search GeneTex for Proteins for FGL1
- ViGene Biosciences adenoviral particle packaged cDNA for FGL1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FGL1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FGL1 gene
- Search ViGene Biosciences for FGL1
- Santa Cruz Biotechnology (SCBT) Antibodies for FGL1
- Search Santa Cruz Biotechnology (SCBT) for FGL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FGL1
- Horizon Cell Lines for FGL1
- Cyagen custom Knockout/knockin (KOKI) mouse models for FGL1
- VectorBuilder custom plasmid, inducible vectors for FGL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FGL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FGL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




