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Aliases for FGL1 Gene

Aliases for FGL1 Gene

  • Fibrinogen Like 1 2 3 5
  • Hepatocyte-Derived Fibrinogen-Related Protein 1 3 4
  • Liver Fibrinogen-Related Protein 1 3 4
  • Hepassocin 3 4
  • LFIRE-1 3 4
  • HFREP1 3 4
  • HP-041 3 4
  • Hepatocellular Carcinoma-Related Sequence 3
  • Fibrinogen-Like Protein 1 3
  • HFREP-1 4
  • LFIRE1 3

External Ids for FGL1 Gene

Previous GeneCards Identifiers for FGL1 Gene

  • GC08M017602
  • GC08M017789
  • GC08M017732
  • GC08M017766
  • GC08M016265
  • GC08M017721

Summaries for FGL1 Gene

Entrez Gene Summary for FGL1 Gene

  • Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGL1 Gene

FGL1 (Fibrinogen Like 1) is a Protein Coding gene. Diseases associated with FGL1 include Hepatocellular Carcinoma and Basal Laminar Drusen. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot for FGL1 Gene

  • Has hepatocyte mitogenic activity.

Gene Wiki entry for FGL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGL1 Gene

Genomics for FGL1 Gene

Regulatory Elements for FGL1 Gene

Enhancers for FGL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G017732 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +174.5 174488 6.5 ARID4B SIN3A FEZF1 BMI1 RAD21 ZNF2 RARA ZNF366 SCRT2 FOS ENSG00000253215 FGL1 NAT1 GC08P017749 GC08P017724
GH08G017846 1.5 FANTOM5 Ensembl ENCODE 11.2 +60.8 60842 5.1 TBP FOXA2 ATF1 ARID4B FEZF1 ZSCAN9 RARA RFX5 ZNF121 ZNF366 MTUS1 ENSG00000253671 ENSG00000253215 FGL1 ENSG00000253944 ASAH1 PCM1 MTMR7 GC08M017832 GC08P017880
GH08G017921 1.7 Ensembl ENCODE dbSUPER 8.8 -15.1 -15058 8.1 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 SP3 TBX21 ZNF610 GLIS1 ENSG00000253671 PCM1 MTUS1 ASAH1 FGL1 SLC7A2 LOC101929066
GH08G017895 1 ENCODE 10.3 +13.8 13802 1.1 HNRNPUL1 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 PAF1 ENSG00000253671 FGL1 ASAH1 MTUS1 ENSG00000254054 PIR60344 GC08M017885
GH08G017915 1.5 Ensembl ENCODE dbSUPER 6.6 -6.1 -6073 1.5 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 PAF1 SP5 MXD4 PCM1 ENSG00000253671 MTUS1 ASAH1 FGL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FGL1 Gene

17,864,380 bp from pter
17,910,365 bp from pter
45,986 bases
Minus strand

Genomic View for FGL1 Gene

Genes around FGL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGL1 Gene

Proteins for FGL1 Gene

  • Protein details for FGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibrinogen-like protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NKU4
    • Q4PJH9
    • Q53YF1
    • Q8NG32
    • Q96KW6
    • Q96QM6

    Protein attributes for FGL1 Gene

    312 amino acids
    Molecular mass:
    36379 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FGL1 Gene

Post-translational modifications for FGL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FGL1 Gene

Domains & Families for FGL1 Gene

Gene Families for FGL1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FGL1: view

No data available for UniProtKB/Swiss-Prot for FGL1 Gene

Function for FGL1 Gene

Molecular function for FGL1 Gene

GENATLAS Biochemistry:
fibrinogen related gene overexpressed in hepatocellular carcinoma
UniProtKB/Swiss-Prot Function:
Has hepatocyte mitogenic activity.
genes like me logo Genes that share phenotypes with FGL1: view

Animal Models for FGL1 Gene

MGI Knock Outs for FGL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGL1

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGL1 Gene

Localization for FGL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGL1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGL1 gene
Compartment Confidence
extracellular 5
mitochondrion 2
lysosome 1

Gene Ontology (GO) - Cellular Components for FGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005577 fibrinogen complex TAS 8390249
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FGL1: view

Pathways & Interactions for FGL1 Gene

No Data Available

Interacting Proteins for FGL1 Gene

Selected Interacting proteins: Q08830-FGL1_HUMAN for FGL1 Gene via IID

Gene Ontology (GO) - Biological Process for FGL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FGL1 Gene

Drugs & Compounds for FGL1 Gene

(1) Additional Compounds for FGL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGL1: view

Transcripts for FGL1 Gene

Unigene Clusters for FGL1 Gene

Fibrinogen-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGL1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - - - -
SP10: - - - -
SP12: -

Relevant External Links for FGL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGL1 Gene

mRNA differential expression in normal tissues according to GTEx for FGL1 Gene

This gene is overexpressed in Liver (x47.8) and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for FGL1 Gene

This gene is overexpressed in Plasma (45.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FGL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGL1 Gene:


SOURCE GeneReport for Unigene cluster for FGL1 Gene:


mRNA Expression by UniProt/SwissProt for FGL1 Gene:

Tissue specificity: Liver specific.

Evidence on tissue expression from TISSUES for FGL1 Gene

  • Liver(4.9)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with FGL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGL1 Gene

Orthologs for FGL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FGL1 35 34
  • 99.25 (n)
(Canis familiaris)
Mammalia FGL1 34 35
  • 90.4 (n)
(Bos Taurus)
Mammalia FGL1 34 35
  • 89.42 (n)
(Mus musculus)
Mammalia Fgl1 34 16 35
  • 84.4 (n)
(Rattus norvegicus)
Mammalia Fgl1 34
  • 81.4 (n)
(Monodelphis domestica)
Mammalia FGL1 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia FGL1 35
  • 70 (a)
(Gallus gallus)
Aves FGL1 34 35
  • 72.57 (n)
(Anolis carolinensis)
Reptilia FGL1 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgl1 34
  • 67.32 (n)
(Danio rerio)
Actinopterygii FGL1 35
  • 62 (a)
LOC100003029 34
  • 61.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5550 36
  • 39 (a)
Species where no ortholog for FGL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGL1 Gene

Gene Tree for FGL1 (if available)
Gene Tree for FGL1 (if available)

Paralogs for FGL1 Gene

Paralogs for FGL1 Gene

genes like me logo Genes that share paralogs with FGL1: view

Variants for FGL1 Gene

Sequence variations from dbSNP and Humsavar for FGL1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000009960 -- 17,879,857(+) ATTAG(C/G)TGCCC intron-variant
rs1000085027 -- 17,871,916(+) AATAC(A/G)TTTGA intron-variant
rs1000171537 -- 17,873,492(+) GATTT(C/G)TGAGA intron-variant
rs1000219416 -- 17,896,314(+) CTACT(A/G)GACTT upstream-variant-2KB, utr-variant-5-prime
rs1000237583 -- 17,868,244(+) ATATA(C/T)ATGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGL1 Gene

Variant ID Type Subtype PubMed ID
dgv12044n54 CNV gain 21841781
dgv12045n54 CNV loss 21841781
dgv1385e214 CNV loss 21293372
dgv3787n106 CNV deletion 24896259
dgv7121n100 CNV gain 25217958
esv1012336 CNV insertion 17803354
esv1091529 CNV deletion 17803354
esv1120408 CNV insertion 17803354
esv1981831 CNV deletion 18987734
esv24086 CNV loss 19812545
esv24172 CNV loss 19812545
esv2421689 CNV deletion 20811451
esv2657492 CNV deletion 23128226
esv2664484 CNV deletion 23128226
esv2736697 CNV deletion 23290073
esv2736698 CNV deletion 23290073
esv2736699 CNV deletion 23290073
esv2762735 CNV gain 21179565
esv3543160 CNV deletion 23714750
esv3616500 CNV gain 21293372
esv3616503 CNV gain 21293372
esv3616505 CNV loss 21293372
esv3690 CNV loss 18987735
esv999314 CNV deletion 20482838
nsv1024843 CNV loss 25217958
nsv1034118 CNV loss 25217958
nsv1075121 CNV deletion 25765185
nsv1076066 CNV deletion 25765185
nsv1128407 CNV deletion 24896259
nsv1147006 CNV deletion 26484159
nsv397275 CNV deletion 16902084
nsv477939 CNV novel sequence insertion 20440878
nsv610701 CNV gain 21841781
nsv610706 CNV loss 21841781
nsv610707 CNV loss 21841781
nsv610712 CNV gain 21841781
nsv824560 CNV loss 20364138
nsv831250 CNV loss 17160897
nsv958486 CNV deletion 24416366

Variation tolerance for FGL1 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.94; 89.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGL1 Gene

Disorders for FGL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FGL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
basal laminar drusen
  • cuticular drusen
- elite association - COSMIC cancer census association via MalaCards
Search FGL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FGL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGL1 Gene

Publications for FGL1 Gene

  1. Molecular cloning and initial characterization of a novel fibrinogen- related gene, HFREP-1. (PMID: 8390249) Yamamoto T. … Hirohashi S. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 22 64
  2. Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity. (PMID: 11470158) Hara H. … Shiokawa K. (Biochim. Biophys. Acta 2001) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64

Products for FGL1 Gene

Sources for FGL1 Gene

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