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Aliases for FGGY Gene

Aliases for FGGY Gene

  • FGGY Carbohydrate Kinase Domain Containing 2 3
  • EC 2.7.1.- 4
  • EC 2.7.1 63

External Ids for FGGY Gene

Previous GeneCards Identifiers for FGGY Gene

  • GC01P059535
  • GC01P059762
  • GC01P057873

Summaries for FGGY Gene

Entrez Gene Summary for FGGY Gene

  • This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for FGGY Gene

FGGY (FGGY Carbohydrate Kinase Domain Containing) is a Protein Coding gene. GO annotations related to this gene include kinase activity and phosphotransferase activity, alcohol group as acceptor.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGGY Gene

Genomics for FGGY Gene

Regulatory Elements for FGGY Gene

Genomic Location for FGGY Gene

Start:
59,296,638 bp from pter
End:
59,767,675 bp from pter
Size:
471,038 bases
Orientation:
Plus strand

Genomic View for FGGY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGGY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGGY Gene

Proteins for FGGY Gene

  • Protein details for FGGY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C11-FGGY_HUMAN
    Recommended name:
    FGGY carbohydrate kinase domain-containing protein
    Protein Accession:
    Q96C11
    Secondary Accessions:
    • B1AK92
    • B1AK93
    • B1AK94
    • B2RDR8
    • D3DQ56
    • Q9HA63
    • Q9NV20

    Protein attributes for FGGY Gene

    Size:
    551 amino acids
    Molecular mass:
    59993 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14947.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FGGY Gene

neXtProt entry for FGGY Gene

Proteomics data for FGGY Gene at MOPED

Selected DME Specific Peptides for FGGY Gene

Post-translational modifications for FGGY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for FGGY Gene

Protein Domains for FGGY Gene

Graphical View of Domain Structure for InterPro Entry

Q96C11

UniProtKB/Swiss-Prot:

FGGY_HUMAN :
  • Q96C11
Family:
  • Belongs to the FGGY kinase family.
genes like me logo Genes that share domains with FGGY: view

No data available for Gene Families for FGGY Gene

Function for FGGY Gene

Enzyme Numbers (IUBMB) for FGGY Gene

Gene Ontology (GO) - Molecular Function for FGGY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016301 kinase activity IEA --
GO:0016773 phosphotransferase activity, alcohol group as acceptor IEA --
genes like me logo Genes that share ontologies with FGGY: view

miRNA for FGGY Gene

miRTarBase miRNAs that target FGGY

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FGGY Gene

Localization for FGGY Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGGY Gene COMPARTMENTS Subcellular localization image for FGGY gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FGGY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with FGGY: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FGGY Gene

Pathways for FGGY Gene

SuperPathways for FGGY Gene

No Data Available

Interacting Proteins for FGGY Gene

Gene Ontology (GO) - Biological Process for FGGY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0008219 cell death --
GO:0016310 phosphorylation IEA --
GO:0070050 neuron cellular homeostasis IMP 17671248
genes like me logo Genes that share ontologies with FGGY: view

No data available for Pathways by source for FGGY Gene

Transcripts for FGGY Gene

Unigene Clusters for FGGY Gene

FGGY carbohydrate kinase domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGGY Gene

No ASD Table

Relevant External Links for FGGY Gene

GeneLoc Exon Structure for
FGGY
ECgene alternative splicing isoforms for
FGGY

Expression for FGGY Gene

mRNA expression in normal human tissues for FGGY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGGY Gene

This gene is overexpressed in Liver (9.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FGGY Gene

SOURCE GeneReport for Unigene cluster for FGGY Gene Hs.444301

mRNA Expression by UniProt/SwissProt for FGGY Gene

Q96C11-FGGY_HUMAN
Tissue specificity: Expressed in kidney, lung and small intestine and to a lower extent in liver and detected in cerebrospinal fluid (at protein level).
genes like me logo Genes that share expressions with FGGY: view

Orthologs for FGGY Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FGGY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGGY 35
  • 99.4 (n)
  • 99.27 (a)
FGGY 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGGY 35
  • 90.36 (n)
  • 92.36 (a)
FGGY 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGGY 35
  • 90.62 (n)
  • 92.74 (a)
FGGY 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fggy 35
  • 88.16 (n)
  • 91.44 (a)
Fggy 16
Fggy 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fggy 35
  • 87.37 (n)
  • 91.26 (a)
chicken
(Gallus gallus)
Aves FGGY 35
  • 75.9 (n)
  • 77.78 (a)
FGGY 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGGY 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fggy 35
  • 69.98 (n)
  • 73.16 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.19740 35
fggy 35
  • 62.41 (n)
  • 63.15 (a)
fggy 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005956 35
  • 54.84 (n)
  • 52.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11594 35
  • 54.98 (n)
  • 50 (a)
CG11594 36
  • 49 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR092W 35
  • 48.39 (n)
  • 41.32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 32 (a)
OneToOne
-- 38
YDR109C 35
  • 49.13 (n)
  • 42.36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19041g 35
  • 50.4 (n)
  • 45.98 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G30310 35
  • 53.83 (n)
  • 50.18 (a)
rice
(Oryza sativa)
Liliopsida Os02g0177900 35
  • 56.89 (n)
  • 53.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01701 35
  • 50.34 (n)
  • 43.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for FGGY:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGGY Gene

ENSEMBL:
Gene Tree for FGGY (if available)
TreeFam:
Gene Tree for FGGY (if available)

Paralogs for FGGY Gene

Selected SIMAP similar genes for FGGY Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FGGY: view

No data available for Paralogs for FGGY Gene

Variants for FGGY Gene

Sequence variations from dbSNP and Humsavar for FGGY Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs581975 -- 59,407,277(-) CAGGG(G/T)ACAGG intron-variant
rs582333 -- 59,483,617(-) ACCTG(C/T)CCCAA intron-variant
rs583739 -- 59,483,302(-) AGTCT(A/G)GCAAA intron-variant
rs585368 -- 59,408,410(-) GCAAA(A/G)GGTGT intron-variant
rs585896 -- 59,489,386(-) cagag(A/T)atggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGGY Gene

Variant ID Type Subtype PubMed ID
nsv829982 CNV Loss 17160897
esv2748874 CNV Deletion 23290073
esv2748885 CNV Deletion 23290073
esv271999 CNV Insertion 20981092
esv273066 CNV Insertion 20981092
nsv870485 CNV Loss 21882294
esv1430411 CNV Insertion 17803354
nsv461639 CNV Loss 19166990
nsv523577 CNV Loss 19592680
nsv1043 CNV Loss 18451855
nsv871532 CNV Gain 21882294
esv2657989 CNV Deletion 23128226
esv2421406 CNV Deletion 20811451
nsv441695 CNV CNV 18776908
nsv822887 CNV Loss 20364138
esv2675145 CNV Deletion 23128226
esv28159 CNV Loss 19812545
esv994342 CNV Loss 20482838
esv2674836 CNV Deletion 23128226
dgv44n67 CNV Loss 20364138
esv1008172 CNV Loss 20482838
nsv822921 CNV Loss 20364138
nsv819226 CNV Gain 19587683
nsv820893 CNV Deletion 20802225
esv22806 CNV Gain 19812545
dgv45n67 CNV Gain 20364138
esv2663896 CNV Deletion 23128226
nsv829993 CNV Loss 17160897

Relevant External Links for FGGY Gene

HapMap Linkage Disequilibrium report
FGGY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGGY Gene

Disorders for FGGY Gene

UniProtKB/Swiss-Prot

FGGY_HUMAN
  • Amyotrophic lateral sclerosis (ALS) [MIM:105400]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:17671248}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for FGGY Gene

Relevant External Links for FGGY

Genetic Association Database (GAD)
FGGY
Human Genome Epidemiology (HuGE) Navigator
FGGY
genes like me logo Genes that share disorders with FGGY: view

Publications for FGGY Gene

  1. Whole-genome analysis of sporadic amyotrophic lateral sclerosis. (PMID: 17671248) Dunckley T. … Stephan D.A. (N. Engl. J. Med. 2007) 2 3 4 48
  2. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. (PMID: 19193627) ChiA^ A. … Traynor B.J. (Hum. Mol. Genet. 2009) 3 48
  3. No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort. (PMID: 19464757) FernA!ndez-Santiago R. … Gasser T. (Neurobiol. Aging 2011) 3 48
  4. Genomewide association study of movement-related adverse antipsychotic effects. (PMID: 19875103) Aberg K. … van den Oord E.J. (Biol. Psychiatry 2010) 3 48
  5. Clinical and genetic features of patients with sporadic amyotrophic lateral sclerosis in south-west China. (PMID: 19922123) Fang D.F. … Shang H.F. (Amyotroph Lateral Scler 2009) 3 48

Products for FGGY Gene

Sources for FGGY Gene

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