FGGY Gene
protein-coding GIFtS: 46
GCID: GC01P059762
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FGGY carbohydrate kinase domain containing
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Aliases
for FGGY gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FGGY Carbohydrate Kinase Domain Containing1 2 | | FLJ109861 | | FGGY Carbohydrate Kinase Domain-Containing Protein2 | | EC 2.7.1.-3 | | EC 2.7.18 |
Export aliases for FGGY gene to outside databasesPrevious GC identifers: GC01P059535 GC01P057873 |
Summaries
for FGGY gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FGGY:
This gene encodes a member of the FGGY kinase family which acts as a phosphotransferase. Some GWAS studies have foundan association with amyotrophic lateral sclerosis patients, yet other GWAS studies have not found any association.(provided by RefSeq, Sep 2011)
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Genomic Views
for FGGY gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FGGY gene promoter:
LHX3b/Lhx3b p53 HNF-4alpha1 S8 POU2F1 POU2F1a HSF2 Sox9 LHX3a/Lhx3a Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for FGGY
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGGY |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p32.1 Ensembl cytogenetic band: 1p32.1 HGNC cytogenetic band: 1p32.1FGGY Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P059762: view genomic region
(about GC identifiers)
Start:
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59,762,310 bp from pter |
End:
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60,233,347 bp from pter |
Size:
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471,038 bases |
Orientation:
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plus strand |
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Proteins
for FGGY gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FGGY_HUMAN, Q96C11 (See
protein sequence)Recommended Name: FGGY carbohydrate kinase domain-containing protein Size: 551 amino acids; 59993 Da
Developmental stage: Expressed in fetal brain (at protein level)
Sequence caution: Sequence=AAH14947.1; Type=Erroneous initiation;
Secondary accessions: B1AK92 B1AK93 B1AK94 B2RDR8 D3DQ56 Q9HA63Alternative splicing: 5 isoforms: Q96C11-1 Q96C11-2 Q96C11-4 Q96C11-3 Q96C11-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FGGY: NX_Q96C11
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96C11
4 DME Specific Peptides for FGGY (Q96C11)
FGGY Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001106882.1 NP_001231643.1 NP_060761.3
ENSEMBL proteins: ENSP00000463260 ENSP00000406607 ENSP00000360262 ENSP00000305922 ENSP00000403425 ENSP00000360256 ENSP00000360254
Human Recombinant Protein Products for FGGY:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
FGGY for ontologies About GeneDecksing
FGGY Antibody Products:
Assay Products for FGGY: |
Protein
Domains /
Families
for FGGY gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FGGY for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96C11ProtoNet protein and cluster: Q96C11 UniProtKB/Swiss-Prot: FGGY_HUMAN, Q96C11Similarity: Belongs to the FGGY kinase family |
Function
for FGGY gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Numbers (IUBMB): EC 2.7.1.-1 EC 2.7.12
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0016301 | kinase activity |
IEA | -- | | GO:0016773 | phosphotransferase activity, alcohol group as acceptor |
IEA | -- |
FGGY for ontologies About GeneDecksing
Phenotypes:
1 MGI phenotypic allele  for Fggy (no phenotypes)
FGGY for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGGY (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGGY (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FGGY (NM_018291) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FGGY | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGGY |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGGY |
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Pathways & Interactions
for FGGY gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FGGY
3 Interacting proteins for FGGY (Q96C113) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
FGGY for ontologies About GeneDecksing
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Drugs & Compounds
for FGGY gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FGGY
Search CenterWatch for drugs/clinical trials and news about FGGY
|
Transcripts
for FGGY gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FGGY gene (3 alternative transcripts): NM_001113411.1 NM_001244714.1 NM_018291.3 Unigene Cluster for FGGY: FGGY carbohydrate kinase domain containing Hs.444301 [show with all ESTs]Unigene Representative Sequence: AK09056818/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000582567 ENST00000413489 ENST00000474476 ENST00000462744 ENST00000371218(uc009wac.3 uc001czi.4)
ENST00000495718(uc001czg.2) ENST00000583635 ENST00000303721(uc001czm.4)
ENST00000430447(uc001czh.2) ENST00000371212(uc001czl.4) ENST00000475949
ENST00000485720 ENST00000371210 ENST00000493891 ENST00000466791 ENST00000476939
ENST00000472783 ENST00000471169
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGGY (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGGY (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FGGY (NM_018291) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FGGY | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGGY |
Additional cDNA sequence: AK001848.1 AK022237.1 AK054842.1 AK090568.1 AK315649.1 BC000610.2 BC014947.1 BX647626.1 20 DOTS entries: DT.437862 DT.95339918 DT.100044268 DT.121326626 DT.95166987 DT.100044405 DT.100772917 DT.100779440 DT.100779443 DT.100044403 DT.100739393 DT.100727168 DT.75102673 DT.100779445 DT.100834153 DT.92456033 DT.95147933 DT.95166828 DT.95094649 DT.97765991 24/142 AceView cDNA sequences (see all 142): BQ934625 AU121672 BU149797 AI278286 AK054842 BQ644899 CB138001 CR607394 CA311928 AK022237 BC000610 NM_018291 BC014947 BU556699 BC042048 BX382565 BQ892439 CR609789 BM726496 BQ440371 BX358874 CR599846 BM855106 BM688624
GeneLoc Exon Structure
|
Expression
for FGGY gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FGGY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FGGY Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGGY
SOURCE GeneReport for Unigene cluster: Hs.444301
UniProtKB/Swiss-Prot: FGGY_HUMAN, Q96C11Tissue specificity: Expressed in kidney, lung and small intestine and to a lower extent in liver and detected incerebrospinal fluid (at protein level)
SABiosciences Custom PCR Arrays for FGGY
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGGY
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FGGY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGGY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGGY | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGGY |
Orthologs
for FGGY gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for FGGY gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for FGGY (if available)
TreeFam Gene Tree for FGGY (if available) |
Paralogs
for FGGY gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FGGY gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FGGY (59762310 - 60012310 bp, first 250kb of FGGY)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for FGGY
11 CNVs: 38183 58398 63856 34826 74511 37396 68747 84277 4227 84276 74510
1 Indel: 63867 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGGY |
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Disorders
/ Diseases
for FGGY gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FGGY for disorders About GeneDecksing
OMIM gene information: 611370
OMIM disorders: --
UniProtKB/Swiss-Prot: FGGY_HUMAN, Q96C11
Defects in FGGY are associated with sporadic amyotrophic lateral sclerosis (ALS) [MIM:105400]. Amyotrophiclateral sclerosis is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatalparalysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophiclateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors
5  diseases for FGGY: About MalaCardsamyotrophic lateral sclerosis lateral sclerosis amyotrophic lateral sclerosis (als) neuronitis
alcoholism
1 disease from the University of Copenhagen DISEASES database for FGGY:Amyotrophic lateral sclerosis Human Genome Epidemiology (HuGE) Navigator: FGGY (4 documents)
Export disorders for FGGY gene to outside databases
|
Publications
for FGGY gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FGGY gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FGGY) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Whole-genome analysis of sporadic amyotrophic lateral sclerosis. (PubMed id 17671248)1, 2, 3 Dunckley T.... Stephan D.A. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort. (PubMed id 19464757)1 FernA!ndez-Santiago R....Gasser T. (2011)
- Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922)1 Ramsuran V....Ndung'u T. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
- Genomewide association study of movement-related adve rse antipsychotic effects. (PubMed id 19875103)1 Aberg K....van den Oord E.J. (2010)
- Analysis of DPP6 and FGGY as candidate genes for amyo trophic lateral sclerosis. (PubMed id 20001489)1 Daoud H....Rouleau G.A. (2009)
- A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. (PubMed id 19193627)1 ChiA^ A....Traynor B.J. (2009)
- Clinical and genetic features of patients with sporad ic amyotrophic lateral sclerosis in south-west China. (PubMed id 19922123)1 Fang D.F....Shang H.F. (2009)
|
External Searches for FGGY gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FGGY gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FGGY gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FGGY gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FGGY | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FGGY gene:
Search GeneIP for patents involving FGGY
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FGGY gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FGGY | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGGY | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGGY | | | OriGene Protein Over-expression Lysate for FGGY | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FGGY | | OriGene 3'-UTR Clone for FGGY | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGGY | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGGY | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FGGY | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGGY | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGGY | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGGY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGGY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGGY |
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 | | | FGGY Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGGY |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGGY |
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