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Aliases for FGG Gene

Aliases for FGG Gene

  • Fibrinogen Gamma Chain 2 3
  • Fibrinogen, Gamma Polypeptide 2

External Ids for FGG Gene

Previous GeneCards Identifiers for FGG Gene

  • GC04M156374
  • GC04M155913
  • GC04M155991
  • GC04M156102
  • GC04M155882
  • GC04M155744
  • GC04M155525
  • GC04M151265

Summaries for FGG Gene

Entrez Gene Summary for FGG Gene

  • The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGG Gene

FGG (Fibrinogen Gamma Chain) is a Protein Coding gene. Diseases associated with FGG include fgg-related congenital afibrinogenemia and dysfibrinogenemia. Among its related pathways are Signaling by GPCR and Hemostasis. GO annotations related to this gene include receptor binding and protein binding, bridging. An important paralog of this gene is FIBCD1.

UniProtKB/Swiss-Prot for FGG Gene

  • Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Gene Wiki entry for FGG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGG Gene

Genomics for FGG Gene

Regulatory Elements for FGG Gene

Genomic Location for FGG Gene

Start:
154,604,134 bp from pter
End:
154,612,967 bp from pter
Size:
8,834 bases
Orientation:
Minus strand

Genomic View for FGG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGG Gene

Proteins for FGG Gene

  • Protein details for FGG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02679-FIBG_HUMAN
    Recommended name:
    Fibrinogen gamma chain
    Protein Accession:
    P02679
    Secondary Accessions:
    • A8K057
    • P04469
    • P04470
    • Q53Y18
    • Q96A14
    • Q96KJ3
    • Q9UC62
    • Q9UC63
    • Q9UCF3

    Protein attributes for FGG Gene

    Size:
    453 amino acids
    Molecular mass:
    51512 Da
    Quaternary structure:
    • Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).
    Miscellaneous:
    • The gamma-chain carries the main binding site for the platelet receptor

    Three dimensional structures from OCA and Proteopedia for FGG Gene

    Alternative splice isoforms for FGG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGG Gene

Proteomics data for FGG Gene at MOPED

Post-translational modifications for FGG Gene

  • Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
  • Sulfation of C-terminal tyrosines increases affinity for thrombin.
  • Glycosylation at Asn78 and Asn334
  • Modification sites at PhosphoSitePlus

Other Protein References for FGG Gene

No data available for DME Specific Peptides for FGG Gene

Domains for FGG Gene

Gene Families for FGG Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • FIBC :Fibrinogen C domain containing

Suggested Antigen Peptide Sequences for FGG Gene

Graphical View of Domain Structure for InterPro Entry

P02679

UniProtKB/Swiss-Prot:

FIBG_HUMAN :
  • P02679
Domain:
  • A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with FGG: view

Function for FGG Gene

Molecular function for FGG Gene

GENATLAS Biochemistry: fibrinogen,gamma polypeptide, (see FG@),with a longer form gamma arising by alternative processing
UniProtKB/Swiss-Prot Function: Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Gene Ontology (GO) - Molecular Function for FGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 7822297
GO:0005198 structural molecule activity IDA 8910396
GO:0030674 protein binding, bridging IEA --
GO:0046872 metal ion binding IEA --
GO:0050839 cell adhesion molecule binding IPI 7822297
genes like me logo Genes that share ontologies with FGG: view
genes like me logo Genes that share phenotypes with FGG: view

Animal Models for FGG Gene

MGI Knock Outs for FGG:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FGG Gene

Localization for FGG Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGG Gene COMPARTMENTS Subcellular localization image for FGG gene
Compartment Confidence
extracellular 5
plasma membrane 4
mitochondrion 2
cytosol 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005577 fibrinogen complex IDA 6451630
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with FGG: view

Pathways for FGG Gene

genes like me logo Genes that share pathways with FGG: view

Gene Ontology (GO) - Biological Process for FGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007160 cell-matrix adhesion IDA 10903502
GO:0007165 signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with FGG: view

Compounds for FGG Gene

(1) Drugbank Compounds for FGG Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Sucralfate
54182-58-0 target antagonist

(2) Novoseek inferred chemical compound relationships for FGG Gene

Compound -log(P) Hits PubMed IDs
fibrinogen 82.3 29
rsai 68.3 1
genes like me logo Genes that share compounds with FGG: view

Transcripts for FGG Gene

Unigene Clusters for FGG Gene

Fibrinogen gamma chain:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGG Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a ·
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -
SP8: -
SP9:
SP10: - -
SP11:
SP12: -
SP13: -
SP14:

ExUns: 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for FGG Gene

GeneLoc Exon Structure for
FGG
ECgene alternative splicing isoforms for
FGG

Expression for FGG Gene

mRNA expression in normal human tissues for FGG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGG Gene

This gene is overexpressed in Liver (52.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FGG Gene

SOURCE GeneReport for Unigene cluster for FGG Gene Hs.727584

genes like me logo Genes that share expressions with FGG: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FGG Gene

Orthologs for FGG Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGG 35
  • 99.08 (n)
  • 99.08 (a)
FGG 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGG 35
  • 86.27 (n)
  • 82.13 (a)
FGG 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGG 35
  • 86.89 (n)
  • 84.49 (a)
FGG 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgg 35
  • 82.68 (n)
  • 83.6 (a)
Fgg 16
Fgg 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGG 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGG 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgg 35
  • 82.6 (n)
  • 83.83 (a)
chicken
(Gallus gallus)
Aves FGG 35
  • 70.26 (n)
  • 66.98 (a)
FGG 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGG 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fgg-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fgg 35
  • 67.92 (n)
  • 67.53 (a)
Str.15548 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8421 35
zebrafish
(Danio rerio)
Actinopterygii Dr.4907 35
fgg 35
  • 61.34 (n)
  • 57.28 (a)
fgg 36
  • 56 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for FGG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGG Gene

ENSEMBL:
Gene Tree for FGG (if available)
TreeFam:
Gene Tree for FGG (if available)

Paralogs for FGG Gene

Pseudogenes.org Pseudogenes for FGG Gene

genes like me logo Genes that share paralogs with FGG: view

Variants for FGG Gene

Sequence variations from dbSNP and Humsavar for FGG Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs6061 - 154,604,968(-) CCACT(A/G)TGAAG reference, missense
rs6062 -- 154,609,995(-) ACTGG(A/G)AAGTA intron-variant
rs6063 Pathogenic, - 154,609,725(-) AGAGC(A/G)GGCTT missense, reference
rs6064 -- 154,608,699(-) TTACA(A/T)GCATT intron-variant
rs12739 -- 154,611,869(-) AGTCC(A/G)GGATA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FGG Gene

Variant ID Type Subtype PubMed ID
nsv881601 CNV Loss 21882294

Relevant External Links for FGG Gene

HapMap Linkage Disequilibrium report
FGG
Human Gene Mutation Database (HGMD)
FGG
Locus Specific Mutation Databases (LSDB)
FGG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGG Gene

Disorders for FGG Gene

UniProtKB/Swiss-Prot

FIBG_HUMAN
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269 PubMed:25427968}. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
  • Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]: A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). {ECO:0000269 PubMed:15632207, ECO:0000269 PubMed:2257302, ECO:0000269 PubMed:2976995, ECO:0000269 PubMed:3708159}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for FGG Gene

(4) Novoseek inferred disease relationships for FGG Gene

Disease -log(P) Hits PubMed IDs
congenital afibrinogenemia 97.9 4
afibrinogenemia 96.9 6
hypofibrinogenemia 89.7 2
coagulopathy 60.4 2

Relevant External Links for FGG

Genetic Association Database (GAD)
FGG
Human Genome Epidemiology (HuGE) Navigator
FGG
genes like me logo Genes that share disorders with FGG: view

Publications for FGG Gene

  1. gammaAla82Gly represents a common fibrinogen gamma-chain variant in Caucasians. (PMID: 15795540) Ivaskevicius V. … Oldenburg J. (Blood Coagul. Fibrinolysis 2005) 3 23 48
  2. Fibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: the Rotterdam Study. (PMID: 17264959) Kardys I. … de Maat M.P. (Thromb. Haemost. 2007) 3 23 48
  3. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. (PMID: 18278190) Carty C.L. … Reiner A.P. (Thromb. Haemost. 2008) 3 23 48
  4. Fibrinogen gene variation and ischemic stroke. (PMID: 18331453) Jood K. … Jern C. (J. Thromb. Haemost. 2008) 3 23 48
  5. Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study. (PMID: 18690352) Cheung E.Y. … Breteler M.M. (Thromb. Haemost. 2008) 3 23 48

Products for FGG Gene

  • Addgene plasmids for FGG

Sources for FGG Gene

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