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FGG Gene

protein-coding   GIFtS: 65
GCID: GC04M155525

Fibrinogen Gamma Chain

(Previous names: fibrinogen, gamma polypeptide)
  See FGG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibrinogen Gamma Chain1 2
Fibrinogen, Gamma Polypeptide1 2

External Ids:    HGNC: 36941   Entrez Gene: 22662   Ensembl: ENSG000001715577   OMIM: 1348505   UniProtKB: P026793   

Export aliases for FGG gene to outside databases

Previous GC identifers: GC04M156374 GC04M155913 GC04M155991 GC04M156102 GC04M155882 GC04M155744 GC04M151265


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGG Gene:
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of
three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to
form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of
fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities,
and are mitogens for several cell types. Mutations in this gene lead to several disorders, including
dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants
encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGG Gene:
FGG (fibrinogen gamma chain) is a protein-coding gene. Diseases associated with FGG include dysfibrinogenemia, gamma type, and fgg-related congenital afibrinogenemia. GO annotations related to this gene include protein binding, bridging and receptor binding. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot: FIBG_HUMAN, P02679
Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor
in platelet aggregation

Gene Wiki entry for FGG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FGG gene promoter:
         USF1   Tal-1   USF-1   FOXJ2 (long isoform)   USF2   STAT3   USF-1:USF-2   FOXJ2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGG promoter sequence
   Search Chromatin IP Primers for FGG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q28

FGG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGG gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M155525:  view genomic region     (about GC identifiers)

Start:
155,525,286 bp from pter      End:
155,534,119 bp from pter
Size:
8,834 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FIBG_HUMAN, P02679 (See protein sequence)
Recommended Name: Fibrinogen gamma chain precursor  
Size: 453 amino acids; 51512 Da
Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2
heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity)
Miscellaneous: The gamma-chain carries the main binding site for the platelet receptor
Selected PDB 3D structures from and Proteopedia for FGG (see all 45):
1DUG (3D)        1FIB (3D)        1FIC (3D)        1FID (3D)        1FZA (3D)        1FZB (3D)    
Secondary accessions: A8K057 P04469 P04470 Q53Y18 Q96A14 Q96KJ3 Q9UC62 Q9UC63 Q9UCF3
Alternative splicing: 2 isoforms:  P02679-1   P02679-2   (Present in about 10% of the fibrinogen molecules in plasma but absent from those in the platelets)

Explore the universe of human proteins at neXtProt for FGG: NX_P02679

Explore proteomics data for FGG at MOPED

Post-translational modifications: 

  • Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and
    beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot.
    The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine
    cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers1
  • Sulfation of C-terminal tyrosines increases affinity for thrombin1
  • Glycosylation2 at Asn78, Asn334
  • Modification sites at PhosphoSitePlus

  • See FGG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000500.2  NP_068656.2  

    ENSEMBL proteins: 
     ENSP00000384860   ENSP00000384101   ENSP00000336829   ENSP00000384552   ENSP00000407562  
     ENSP00000377429  
    Reactome Protein details: P02679

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    FIBC: Fibrinogen C domain containing

    5 InterPro protein domains:
     IPR012290 Fibrinogen_a/b/g_coil_dom
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry P02679

    ProtoNet protein and cluster: P02679

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: FIBG_HUMAN, P02679
    Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal
    domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to
    the coiled coil structure
    Similarity: Contains 1 fibrinogen C-terminal domain


    Find genes that share domains with FGG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FIBG_HUMAN, P02679
    Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor
    in platelet aggregation

         Genatlas biochemistry entry for FGG:
    fibrinogen,gamma polypeptide, (see FG@),with a longer form gamma arising by alternative processing

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0030674protein binding, bridging IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with FGG           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FGG:
     Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fgg):
     cardiovascular system  embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  reproductive system  respiratory system 

    Find genes that share phenotypes with FGG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fggtm1Fjc for FGG

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGG
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGG

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    hsa-mir-144-3p (MIRT005523), hsa-mir-409-3p (MIRT005519), hsa-mir-29b-3p (MIRT005522), hsa-mir-29c-3p (MIRT005525), hsa-mir-29a-3p (MIRT005521)

    Block miRNA regulation of human, mouse, rat FGG using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate FGG:
    hsa-miR-548a-3p hsa-miR-548e hsa-miR-26b*
    SwitchGear 3'UTR luciferase reporter plasmidFGG 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FIBG_HUMAN, P02679: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    mitochondrion2
    cytosol1
    lysosome1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005577fibrinogen complex IEA--
    GO:0005615extracellular space IDA6777381
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with FGG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGG About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.51
    Common Pathway0.00
    Blood Clotting Cascade0.42
    Extrinsic Prothrombin Activation Pathway0.00
    2Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    GRB2-SOS provides linkage to MAPK signaling for Intergrins0.00
    Platelet Aggregation (Plug Formation)0.73
    p130Cas linkage to MAPK signaling for integrins0.00
    3Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    4Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    5Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38


    Find genes that share SuperPaths with FGG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGG
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    2 GeneGo (Thomson Reuters) Pathways for FGG
        Cell adhesion Integrin inside-out signaling
    Cell adhesion Plasmin signaling

    3 BioSystems Pathways for FGG
        Blood Clotting Cascade
    IL6-mediated signaling events
    Glucocorticoid receptor regulatory network


    Selected Reactome Pathways for FGG (see all 6)
        Integrin cell surface interactions
    Platelet degranulation
    Integrin alphaIIb beta3 signaling
    p130Cas linkage to MAPK signaling for integrins
    GRB2:SOS provides linkage to MAPK signaling for Integrins

    1 PharmGKB Pathway for FGG
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for FGG):
        Complement and coagulation cascades
    Staphylococcus aureus infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FGG
    Interactions:

        GeneGlobe Interaction Network for FGG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGG (P026793 ENSP000003368294) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGAP026713, ENSP000003063614I2D: score=5 STRING: ENSP00000306361
    FGBP026753, ENSP000003060994I2D: score=3 STRING: ENSP00000306099
    F13BP051603, ENSP000003563824I2D: score=2 STRING: ENSP00000356382
    F13A1P004883, ENSP000002648704I2D: score=1 STRING: ENSP00000264870
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007165signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with FGG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGG (FIBG)

    1 DrugBank Compound for FGG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sucralfate-- 54182-58-0targetantagonist6892775

    2 Novoseek inferred chemical compound relationships for FGG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 82.3 48 20059469 (2), 17264959 (2), 16959688 (1), 17083511 (1) (see all 27)
    rsai 68.3 1 15795544 (1)



    Find genes that share compounds with FGG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGG gene (2 alternative transcripts): 
    NM_000509.4  NM_021870.2  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404648(uc003iog.3) ENST00000492082 ENST00000465913 ENST00000405164
    ENST00000336098(uc003ioj.3) ENST00000407946 ENST00000443553 ENST00000393846
    ENST00000464532 ENST00000473393 ENST00000465336 ENST00000484695
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    hsa-miR-548a-3p hsa-miR-548e hsa-miR-26b*
    SwitchGear 3'UTR luciferase reporter plasmidFGG 3' UTR sequence
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    Selected AceView cDNA sequences (see all 1586):

    CR603524 BG562489 Z19963 BG616937 BG617148 AA344615 AA344638 AA345347 
    CB162122 BG568343 BQ647366 BG617978 T67625 AA344285 BG618654 CR626427 
    BG618611 CB133196 AL532044 CB164342 BG565533 BG545107 BG563233 AA343530 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FGG (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a ·
    SP1:                                                              -                                                                       -           -         
    SP2:                                                              -                                                                                             
    SP3:              -     -           -                             -                                                                                             
    SP4:              -     -                                         -                                                                                             
    SP5:                                                              -                 -                                                                           

    ExUns: 14b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for FGG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTCAATA
    FGG Expression
    About this image


    FGG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
    FGG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGG Protein Expression
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGG gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgg1 , 5 fibrinogen gamma chain1, 5 82.68(n)1
    83.6(a)1
      3 (36.94 cM)5
    995711  NM_133862.11  NP_598623.11 
     830078965 
    chicken
    (Gallus gallus)
    Aves FGG1 fibrinogen gamma chain 70.26(n)
    66.98(a)
      395837  NM_204989.1  NP_990320.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGG6
    fibrinogen gamma chain
    66(a)
    1 ↔ 1
    5(130240041-130249250)
    African clawed frog
    (Xenopus laevis)
    Amphibia fgg-prov2 fibrinogen, gamma polypeptide 79.57(n)    BC054185.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.49072 Danio rerio mRNA similar to fibrinogen, gamma polypeptide (cDNA clone MGC56023 IMAGE3819922), complete cds less 76.87(n)    BC045868.1 


    ENSEMBL Gene Tree for FGG (if available)
    TreeFam Gene Tree for FGG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGG gene
    FGL22  ANGPT42  FIBCD12  ANGPTL62  FCN32  ANGPTL22  FCN22  FCN12  
    ANGPT12  ANGPTL12  ANGPTL72  FGB2  ANGPT22  MFAP42  FGL12  
    12 SIMAP similar genes for FGG using alignment to 6 protein entries:     FIBG_HUMAN (see all proteins):
    DKFZp779N0926    FGL1    LFIRE1    ANGPTL4    FCN1    FGB
    ANGPTL2    FCN3    FIBCD1    MFAP4    FCN2    ANGPTL7

    Find genes that share paralogs with FGG           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FGG
    PGOHUM00000245734


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGG (see all 289)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462184421,2
    Cuntested1155320550(+) TCATCG/ACCAAA 4 /G syn11Minor allele frequency- A:0.00NA 4550
    rs758488041,2
    Cother1155318677(-) AAACCC/G/TGGTGG 4 R G mis10--------
    rs1219130901,2,,4
    Cother1155320515(-) CCATAA/TTGGCA 4 N I mis11Minor allele frequency- T:0.00NA 4552
    rs60631,2,,4
    C,F,Hother1155323407(-) AGAGCG/AGGCTT 4 /R /G mis1 ese314Minor allele frequency- A:0.01MN NS EA NA EU 7199
    rs1860603841,2
    --155317433(+) GCTCTA/GAGTTG 1 -- ds50010--------
    rs1911077391,2
    C--155317563(+) TGTGTA/GGCTGT 1 -- ds50010--------
    rs755543391,2
    C--155317595(+) TTCTTG/TTATAG 1 -- ds50010--------
    rs1824010301,2
    --155317671(+) CATAAC/TTGCTA 1 -- ds50010--------
    rs1179036861,2
    F--155317734(+) ACTCAA/GTTACT 1 -- ds50011Minor allele frequency- G:0.01EA 120
    rs1164104131,2
    F--155317746(+) CTGATG/AGTTGC 1 -- ds50011Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for FGG (155525286 - 155534119 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FGG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv881601CNV Loss21882294

    Human Gene Mutation Database (HGMD): FGG
    Locus Specific Mutation Databases (LSDB): FGG

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGG
    DNA2.0 Custom Variant and Variant Library Synthesis for FGG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134850    OMIM disorders: --

    UniProtKB/Swiss-Prot: FIBG_HUMAN, P02679
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by
    bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet
    fibrinogen. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients with
    congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent,
    some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding

  • 8 diseases for FGG:    
    About MalaCards
    dysfibrinogenemia, gamma type    fgg-related congenital afibrinogenemia    hypofibrinogenemia, gamma type    congenital afibrinogenemia
    dysfibrinogenemia    thrombophilia, dysfibrinogenemic    afibrinogenemia    thrombophilia

    1 disease from the University of Copenhagen DISEASES database for FGG:
    Congenital afibrinogenemia

    Find genes that share disorders with FGG           About GenesLikeMe

    4 Novoseek inferred disease relationships for FGG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital afibrinogenemia 97.9 4 15284111 (2), 10891444 (1), 11354637 (1)
    afibrinogenemia 96.9 6 12511408 (1), 19551918 (1), 10891444 (1), 11354637 (1) (see all 6)
    hypofibrinogenemia 89.7 2 16607083 (1), 18676163 (1)
    coagulopathy 60.4 2 18676163 (1), 19551918 (1)

    Genetic Association Database (GAD): FGG
    Human Genome Epidemiology (HuGE) Navigator: FGG (39 documents)

    Export disorders for FGG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGG gene, integrated from 10 sources (see all 248):
    (articles sorted by number of sources associating them with FGG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study. (PubMed id 18690352)1, 4, 9 Cheung E.Y....Breteler M.M. (Thromb. Haemost. 2008)
    2. Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies. (PubMed id 19515723)1, 4, 9 Nowak-GAPttl U....Stoll M. (Blood 2009)
    3. Fibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: the Rotterdam Study. (PubMed id 17264959)1, 4, 9 Kardys I....de Maat M.P. (Thromb. Haemost. 2007)
    4. Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. (PubMed id 20167083)1, 4, 9 Theodoraki E.V....Dedoussis G.V. (BMC Med. Genet. 2010)
    5. Genetic variation in the fibrinogen-alpha and fibrinogen-gamma genes in relation to arterial stiffness: the Rotterdam Study. (PubMed id 19412134)1, 4, 9 Sie M.P....Witteman J.C. (J. Hypertens. 2009)
    6. Fibrinogen gene variation and ischemic stroke. (PubMed id 18331453)1, 4, 9 Jood K....Jern C. (J. Thromb. Haemost. 2008)
    7. Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study. (PubMed id 20059469)1, 4, 9 Carty C.L....Reiner A.P. (Ann. Hum. Genet. 2010)
    8. gammaAla82Gly represents a common fibrinogen gamma-chain variant in Caucasians. (PubMed id 15795540)1, 4, 9 Ivaskevicius V....Oldenburg J. (amp 2005)
    9. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. (PubMed id 18278190)1, 4, 9 Carty C.L....Reiner A.P. (Thromb. Haemost. 2008)
    10. Assessment of genetic determinants of the association of I^' fibrinogen in relation to cardiovascular disease. (PubMed id 21757653)1, 4 Lovely R.S....Farrell D.H. (Arterioscler. Thromb. Vasc. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2266 HGNC: 3694 AceView: FGG Ensembl:ENSG00000171557 euGenes: HUgn2266
    ECgene: FGG Kegg: 2266 H-InvDB: FGG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FGG Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FGG[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Fibrinogen
    SeattleSNPshttp://pga.gs.washington.edu/data/fgg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGG gene:
    Search GeneIP for patents involving FGG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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