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Aliases for FGG Gene

Aliases for FGG Gene

  • Fibrinogen Gamma Chain 2 3 5
  • Fibrinogen, Gamma Polypeptide 2

External Ids for FGG Gene

Previous GeneCards Identifiers for FGG Gene

  • GC04M156374
  • GC04M155913
  • GC04M155991
  • GC04M156102
  • GC04M155882
  • GC04M155744
  • GC04M155525
  • GC04M151265

Summaries for FGG Gene

Entrez Gene Summary for FGG Gene

  • The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

GeneCards Summary for FGG Gene

FGG (Fibrinogen Gamma Chain) is a Protein Coding gene. Diseases associated with FGG include afibrinogenemia, congenital and dysfibrinogenemia, congenital. Among its related pathways are Platelet activation, signaling and aggregation and Degradation of the extracellular matrix. GO annotations related to this gene include receptor binding and protein binding, bridging. An important paralog of this gene is FGB.

UniProtKB/Swiss-Prot for FGG Gene

  • Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Gene Wiki entry for FGG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGG Gene

Genomics for FGG Gene

Regulatory Elements for FGG Gene

Promoters for FGG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FGG on UCSC Golden Path with GeneCards custom track

Genomic Location for FGG Gene

Chromosome:
4
Start:
154,604,134 bp from pter
End:
154,612,967 bp from pter
Size:
8,834 bases
Orientation:
Minus strand

Genomic View for FGG Gene

Genes around FGG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGG Gene

Proteins for FGG Gene

  • Protein details for FGG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02679-FIBG_HUMAN
    Recommended name:
    Fibrinogen gamma chain
    Protein Accession:
    P02679
    Secondary Accessions:
    • A8K057
    • P04469
    • P04470
    • Q53Y18
    • Q96A14
    • Q96KJ3
    • Q9UC62
    • Q9UC63
    • Q9UCF3

    Protein attributes for FGG Gene

    Size:
    453 amino acids
    Molecular mass:
    51512 Da
    Quaternary structure:
    • Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
    Miscellaneous:
    • The gamma-chain carries the main binding site for the platelet receptor.

    Three dimensional structures from OCA and Proteopedia for FGG Gene

    Alternative splice isoforms for FGG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGG Gene

Proteomics data for FGG Gene at MOPED

Post-translational modifications for FGG Gene

  • Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
  • Sulfation of C-terminal tyrosines increases affinity for thrombin.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGG Gene

No data available for DME Specific Peptides for FGG Gene

Domains & Families for FGG Gene

Suggested Antigen Peptide Sequences for FGG Gene

Graphical View of Domain Structure for InterPro Entry

P02679

UniProtKB/Swiss-Prot:

FIBG_HUMAN :
  • A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
Domain:
  • A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with FGG: view

Function for FGG Gene

Molecular function for FGG Gene

GENATLAS Biochemistry:
fibrinogen,gamma polypeptide, (see FG@),with a longer form gamma arising by alternative processing
UniProtKB/Swiss-Prot Function:
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Gene Ontology (GO) - Molecular Function for FGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050839 cell adhesion molecule binding IPI 7822297
genes like me logo Genes that share ontologies with FGG: view
genes like me logo Genes that share phenotypes with FGG: view

Human Phenotype Ontology for FGG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGG Gene

MGI Knock Outs for FGG:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGG Gene

Localization for FGG Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGG Gene COMPARTMENTS Subcellular localization image for FGG gene
Compartment Confidence
extracellular 5
plasma membrane 5
mitochondrion 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 6777381
GO:0005737 cytoplasm IEA --
GO:0031093 platelet alpha granule lumen TAS --
GO:0072562 blood microparticle IEA,IDA 22516433
genes like me logo Genes that share ontologies with FGG: view

Pathways & Interactions for FGG Gene

SuperPathways for FGG Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Platelet activation, signaling and aggregation
3 Formation of Fibrin Clot (Clotting Cascade)
4 Integrin alphaIIb beta3 signaling
5 Signaling by GPCR
genes like me logo Genes that share pathways with FGG: view

Gene Ontology (GO) - Biological Process for FGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007160 cell-matrix adhesion IDA 10903502
GO:0007165 signal transduction IEA --
GO:0030168 platelet activation IEA --
GO:0031639 plasminogen activation IDA 16846481
genes like me logo Genes that share ontologies with FGG: view

No data available for SIGNOR curated interactions for FGG Gene

Drugs & Compounds for FGG Gene

(3) Drugs for FGG Gene - From: DGIdb, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sucralfate Approved Pharma Target, antagonist 9
Alfimeprase Investigational Pharma 0
RECOMBINANT FACTOR IX FC FUSION PROTEIN Pharma 0

(2) Additional Compounds for FGG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGG: view

Transcripts for FGG Gene

Unigene Clusters for FGG Gene

Fibrinogen gamma chain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGG Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a ·
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -
SP8: -
SP9:
SP10: - -
SP11:
SP12: -
SP13: -
SP14:

ExUns: 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for FGG Gene

GeneLoc Exon Structure for
FGG
ECgene alternative splicing isoforms for
FGG

Expression for FGG Gene

mRNA expression in normal human tissues for FGG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGG Gene

This gene is overexpressed in Liver (x52.4).

Protein differential expression in normal tissues from HIPED for FGG Gene

This gene is overexpressed in Synovial fluid (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FGG Gene



SOURCE GeneReport for Unigene cluster for FGG Gene Hs.727584

mRNA Expression by UniProt/SwissProt for FGG Gene

P02679-FIBG_HUMAN
Tissue specificity: Detected in blood plasma (at protein level).
genes like me logo Genes that share expression patterns with FGG: view

Protein tissue co-expression partners for FGG Gene

- Elite partner

In Situ Assay Products

Orthologs for FGG Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGG 35
  • 86.27 (n)
  • 82.13 (a)
FGG 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGG 35
  • 86.89 (n)
  • 84.49 (a)
FGG 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgg 35
  • 82.68 (n)
  • 83.6 (a)
Fgg 16
Fgg 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGG 35
  • 99.08 (n)
  • 99.08 (a)
FGG 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgg 35
  • 82.6 (n)
  • 83.83 (a)
oppossum
(Monodelphis domestica)
Mammalia FGG 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGG 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGG 35
  • 70.26 (n)
  • 66.98 (a)
FGG 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGG 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgg 35
  • 67.92 (n)
  • 67.53 (a)
Str.15548 35
African clawed frog
(Xenopus laevis)
Amphibia fgg-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.4907 35
fgg 35
  • 61.34 (n)
  • 57.28 (a)
fgg 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8421 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for FGG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGG Gene

ENSEMBL:
Gene Tree for FGG (if available)
TreeFam:
Gene Tree for FGG (if available)

Paralogs for FGG Gene

Pseudogenes.org Pseudogenes for FGG Gene

genes like me logo Genes that share paralogs with FGG: view

Variants for FGG Gene

Sequence variations from dbSNP and Humsavar for FGG Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_002409 -
VAR_002410 Dysfibrinogenemia, congenital (DYSFIBRIN)
VAR_002411 Dysfibrinogenemia, congenital (DYSFIBRIN)
VAR_002412 -
rs121913090 - 154,606,833(-) CCATA(A/T)TGGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FGG Gene

Variant ID Type Subtype PubMed ID
nsv881601 CNV Loss 21882294

Variation tolerance for FGG Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGG Gene

HapMap Linkage Disequilibrium report
FGG
Human Gene Mutation Database (HGMD)
FGG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGG Gene

Disorders for FGG Gene

MalaCards: The human disease database

(8) MalaCards diseases for FGG Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
afibrinogenemia, congenital
  • hypofibrinogenemia, congenital
dysfibrinogenemia, congenital
  • hypodysfibrinogenemia, congenital
hypofibrinogenemia, familial
  • familial hypofibrinogenemia
familial hypodysfibrinogenemia
dysfibrinogenemia
  • dysfibrinogenemia, congenital
- elite association - COSMIC cancer census association via MalaCards
Search FGG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FIBG_HUMAN
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269 PubMed:25427968}. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
  • Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]: A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). {ECO:0000269 PubMed:15632207, ECO:0000269 PubMed:2257302, ECO:0000269 PubMed:2976995, ECO:0000269 PubMed:3708159}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FGG

Genetic Association Database (GAD)
FGG
Human Genome Epidemiology (HuGE) Navigator
FGG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGG
genes like me logo Genes that share disorders with FGG: view

No data available for Genatlas for FGG Gene

Publications for FGG Gene

  1. Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study. (PMID: 18690352) Cheung E.Y. … Breteler M.M. (Thromb. Haemost. 2008) 3 23 48 67
  2. Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study. (PMID: 20059469) Carty C.L. … Reiner A.P. (Ann. Hum. Genet. 2010) 3 23
  3. Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. (PMID: 20167083) Theodoraki E.V. … Dedoussis G.V. (BMC Med. Genet. 2010) 3 23
  4. Genetic variation in the fibrinogen-alpha and fibrinogen-gamma genes in relation to arterial stiffness: the Rotterdam Study. (PMID: 19412134) Sie M.P. … Witteman J.C. (J. Hypertens. 2009) 3 23
  5. Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies. (PMID: 19515723) Nowak-GAPttl U. … Stoll M. (Blood 2009) 3 23

Products for FGG Gene

Sources for FGG Gene

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