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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGG Gene

protein-coding   GIFtS: 66
GCID: GC04M155525

fibrinogen gamma chain

(Previous names: fibrinogen, gamma polypeptide )
 Explore 32 diseases affiliated with
FGG via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FGG    

Aliases
for FGG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fibrinogen Gamma Chain1 2
Fibrinogen, Gamma Polypeptide1 2

External Ids:    HGNC: 36941   Entrez Gene: 22662   Ensembl: ENSG000001715577   OMIM: 1348505   UniProtKB: P026793   

Export aliases for FGG gene to outside databases

Previous GC identifers: GC04M156374 GC04M155913 GC04M155991 GC04M156102 GC04M155882 GC04M155744 GC04M151265


Summaries
for FGG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FGG:
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three
pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin
which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin
regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several
cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and
thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FIBG_HUMAN, P02679
Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in
platelet aggregation

Gene Wiki entry for FGG


Genomic Views
for FGG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGG gene promoter:
         USF1   Tal-1   USF-1   FOXJ2 (long isoform)   USF2   STAT3   USF-1:USF-2   FOXJ2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGG promoter sequence
   Search SABiosciences Chromatin IP Primers for FGG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q28

FGG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGG gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M155525:  view genomic region     (about GC identifiers)

Start:
 155,525,286 bp from pter      End:
 155,534,119 bp from pter
Size:
 8,834 bases      Orientation:
 minus strand

Proteins
for FGG gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FIBG_HUMAN, P02679 (See protein sequence)
Recommended Name: Fibrinogen gamma chain precursor  
Size: 453 amino acids; 51512 Da
Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2
heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity)
Subcellular location: Secreted
Miscellaneous: The gamma-chain carries the main binding site for the platelet receptor
6/44 PDB 3D structures from and Proteopedia for FGG (see all 44):
1DUG (3D)        1FIB (3D)        1FIC (3D)        1FID (3D)        1FZA (3D)        1FZB (3D)    
Secondary accessions: A8K057 P04469 P04470 Q53Y18 Q96A14 Q96KJ3 Q9UC62 Q9UC63 Q9UCF3
Alternative splicing: 2 isoforms:  P02679-1   P02679-2   (Present in about 10% of the fibrinogen molecules in plasma but absent from those in the platelets)

Explore the universe of human proteins at neXtProt for FGG: NX_P02679

Post-translational modifications:

  • Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta
    • chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft
    clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking
    between gamma chains (stronger) and between alpha chains (weaker) of different monomers1
  • Sulfation of C-terminal tyrosines increases affinity for thrombin1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P02679

    • FGG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000500.2  NP_068656.2  

    ENSEMBL proteins: 
     ENSP00000384860   ENSP00000384101   ENSP00000336829   ENSP00000384552   ENSP00000407562  
     ENSP00000377429  
    Reactome Protein details: P02679
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005577fibrinogen complex IEA--
    GO:0005615extracellular space IDA6777381
    GO:0005886plasma membrane TAS--
    GO:0005938cell cortex IEA--


    FGG for ontologies           About GeneDecksing



    FGG Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for FGG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FGG for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR012290 Fibrinogen_a/b/g_coil_dom
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry P02679

    ProtoNet protein and cluster: P02679

    1 Blocks protein family: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: FIBG_HUMAN, P02679
    Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal
    domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the
    coiled coil structure
    Similarity: Contains 1 fibrinogen C-terminal domain


    Function
    for FGG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FIBG_HUMAN, P02679
    Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in
    platelet aggregation

         Genatlas biochemistry entry for FGG:
    fibrinogen,gamma polypeptide, (see FG@),with a longer form gamma arising by alternative processing

    miRNA
    Products:            		miRTarBase miRNAs that target FGG:
    hsa-mir-144 (MIRT005523), hsa-mir-409-3p (MIRT005519), hsa-mir-29b (MIRT005522), hsa-mir-29c (MIRT005525), hsa-mir-29a (MIRT005521)

    OriGene 3'-UTR Clone (see all 2): FGG
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate FGG:
    hsa-miR-548a-3p hsa-miR-548e hsa-miR-26b*
    SwitchGear 3'UTR luciferase reporter plasmid: FGG 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGG (see all 7)
    OriGene shRNA RFP: FGG
    OriGene siRNA: FGG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGG

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FGG

    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0030674protein binding, bridging IEA--
    GO:0043499eukaryotic cell surface binding IDA6777381
    GO:0046872metal ion binding IEA--


    FGG for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FGG:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Fggtm1Fjc for FGG
         9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Fgg):
     cardiovascular system  embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  reproductive system  respiratory system 

    FGG for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FGG gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Common Pathway
    		Common Pathway1.00
    		fibrin multimer -> fibrin multimer, crosslinked + NH4+0.36
    		Extrinsic Prothrombin Activation Pathway0.69
    2Cell adhesion_Integrin inside-out signaling
    		Cell adhesion_Integrin inside-out signaling1.00
    		Cell adhesion Integrin inside-out signaling0.99
    3Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43
    4Platelet degranulation
    		Platelet degranulation 1.00
    		Response to elevated platelet cytosolic Ca2+0.94
    5Integrin alphaIIb beta3 signaling
    		Integrin alphaIIb beta3 signaling1.00
    		Platelet Aggregation (Plug Formation)0.73

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for FGG
        Cell adhesion Integrin inside-out signaling
    Metalloproteases in connective tissue degradation
    Cell adhesion Plasmin signaling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGG
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    2 GeneGo (Thomson Reuters) Pathways for FGG
        Cell adhesion Integrin inside-out signaling
    Cell adhesion Plasmin signaling

    3 BioSystems Pathways for FGG 
        Blood Clotting Cascade
    IL6-mediated signaling events
    Glucocorticoid receptor regulatory network

    5/13        Reactome Pathways for FGG (see all 13)
        Hemostasis
    Integrin cell surface interactions
    Response to elevated platelet cytosolic Ca2+
    p130Cas linkage to MAPK signaling for integrins
    Common Pathway

    1 PharmGKB Pathway for FGG
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for FGG):
        Complement and coagulation cascades
    Staphylococcus aureus infection


    FGG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for FGG (P026793 ENSP000003368294) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGAP026713, ENSP000003063614I2D: score=5 STRING: ENSP00000306361
    FGBP026753, ENSP000003060994I2D: score=3 STRING: ENSP00000306099
    F13BP051603, ENSP000003563824I2D: score=2 STRING: ENSP00000356382
    F13A1P004883, ENSP000002648704I2D: score=1 STRING: ENSP00000264870
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007165signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0051258protein polymerization IEA--


    FGG for ontologies           About GeneDecksing



    Drugs & Compounds
    for FGG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGG

    1 DrugBank Compound for FGG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sucralfate-- 54182-58-0targetantagonist6892775

    2 Novoseek chemical compound relationships for FGG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 82.3 48 20059469 (2), 17264959 (2), 16959688 (1), 17083511 (1) (see all 27)
    rsai 68.3 1 15795544 (1)

    Search CenterWatch for drugs/clinical trials and news about FGG / FIBG 

    Transcripts
    for FGG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FGG gene (2 alternative transcripts): 
    NM_000509.4  NM_021870.2  

    Unigene Cluster for FGG:

    Fibrinogen gamma chain
    Hs.727584  [show with all ESTs]
    Unigene Representative Sequence: NM_021870
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404648(uc003iog.3) ENST00000492082 ENST00000465913 ENST00000405164
    ENST00000336098(uc003ioj.3) ENST00000407946 ENST00000443553 ENST00000393846
    ENST00000464532 ENST00000473393 ENST00000465336 ENST00000484695

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGG
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate FGG:
    hsa-miR-548a-3p hsa-miR-548e hsa-miR-26b*
    SwitchGear 3'UTR luciferase reporter plasmid: FGG 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK289422.1 AK290824.1 BC007044.1 BC021674.1 BT007081.1 BX538098.1 X00086.1 X51473.1 

    24/52 DOTS entries (see all 52):

    DT.100808460  DT.100889225  DT.100889199  DT.100889221  DT.100889213  DT.86840463  DT.121231047  DT.100889200 
    DT.100889220  DT.95275417  DT.100889218  DT.100889205  DT.121231054  DT.100889165  DT.91975594  DT.95275372 
    DT.95275413  DT.100889222  DT.91783131  DT.91783119  DT.100889186  DT.100889171  DT.100889161  DT.100889170 

    24/1586 AceView cDNA sequences (see all 1586):

    AA343530 AA343857 BG616736 CB116646 BG564427 AV692558 AL531992 CR621472 
    CR599176 BG616937 AA344006 CR596270 CR598376 AA344597 CR616498 BG618891 
    AL531088 BG565980 BG616940 BX449114 BG617637 AL579746 CB141244 CR593597 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for FGG (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a ·
    SP1:                                                              -                                                                       -           -         
    SP2:                                                              -                                                                                             
    SP3:              -     -           -                             -                                                                                             
    SP4:              -     -                                         -                                                                                             
    SP5:                                                              -                 -                                                                           

    ExUns: 14b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for FGG

    Expression
    for FGG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTTCAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FGG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMature Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Embryoid bodies (Two-step protocol fo...)

    See FGG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGG

    SOURCE GeneReport for Unigene cluster: Hs.727584
        SABiosciences Custom PCR Arrays for FGG
    Primer
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    Orthologs
    for FGG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FGG gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FGG1 fibrinogen gamma chain 71.31(n)
    68.03(a)    		   395837  NM_204989.1  NP_990320.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FGG6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 5(130240285-130248094)
    African clawed frog
    (Xenopus laevis)    		 Amphibia fgg-prov2 fibrinogen, gamma polypeptide 79.57(n)    BC054185.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.49072 Danio rerio mRNA similar to fibrinogen, gamma polypeptide more 76.87(n)    BC045868.1 


    ENSEMBL Gene Tree for FGG (if available)
    TreeFam Gene Tree for FGG (if available) 

    Paralogs
    for FGG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGG gene
    FGL22  ANGPT42  FGA2  ANGPTL62  ANGPTL22  ANGPTL42  ANGPT12  ANGPTL32  
    ANGPTL12  ANGPTL72  ANGPT22  FGB2  FGL12  
    13 SIMAP similar genes for FGG using alignment to 6 protein entries:     FIBG_HUMAN (see all proteins):
    DKFZp779N0926    FGL1    LFIRE1    ANGPTL4    FCN1    FGB
    ANGPTL2    FCN3    FIBCD1    MFAP4    FCN2    ANGPTL7
    ANGPT1

    FGG for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FGG
    PGOHUM00000245734


    Genomic Variants
    for FGG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): FGG

    Locus Specific Mutation Databases (LSDB): FGG
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGG
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    Disorders / Diseases
    for FGG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FGG for disorders           About GeneDecksing

    OMIM gene information: 134850    OMIM disorders: --

    UniProtKB/Swiss-Prot: FIBG_HUMAN, P02679
  • Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This rare autosomal recessive
    • disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels
    of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different
    clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a
    predisposition for thrombosis with or without bleeding

    20/32 diseases for FGG (see all 32):    About MalaCards
    hypofibrinogenemia    dysfibrinogenemia    thrombophilia    dysfibrinogenemia, gamma type
    hypofibrinogenemia, gamma type    thrombophilia, dysfibrinogenemic    afibrinogenemia    age related macular degeneration
    congenital afibrinogenemia    blood clots    non-hodgkin lymphoma    macular degeneration
    myocardial infarction    acute myocardial infarction    hodgkin's lymphoma    crohn's disease
    hepatitis b    kidney disease    thrombosis    homocysteine

    1 disease from the University of Copenhagen DISEASES database for FGG:
    Congenital afibrinogenemia

    4 Novoseek disease relationships for FGG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital afibrinogenemia 97.9 4 15284111 (2), 10891444 (1), 11354637 (1)
    afibrinogenemia 96.9 6 12511408 (1), 19551918 (1), 10891444 (1), 11354637 (1) (see all 6)
    hypofibrinogenemia 89.7 2 16607083 (1), 18676163 (1)
    coagulopathy 60.4 2 18676163 (1), 19551918 (1)

    Genetic Association Database (GAD): FGG
    Human Genome Epidemiology (HuGE) Navigator: FGG (39 documents)

    Export disorders for FGG gene to outside databases

    Publications
    for FGG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGG gene, integrated from 9 sources (see all 225):
    (articles sorted by number of sources associating them with FGG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. gammaAla82Gly represents a common fibrinogen gamma-chain variant in Caucasians. (PubMed id 15795540)1, 4, 9 Ivaskevicius V....Oldenburg J. (2005)
    2. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (2006)
    3. Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction. (PubMed id 15735812)1, 4 Mannila M.N....Silveira A. (2005)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen gamma' levels. (PubMed id 16144795)1, 4 Uitte de Willige S....Bertina R.M. (2005)
    6. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Fibrinogen Hillsborough: a novel gamma-gly309asp dysfibrinogen with impaired clotting. (PubMed id 11986213)1, 2 Mullin J.L.... George P.M. (2002)
    9. Fibrinogen Milano XII: a dysfunctional variant containing 2 amino acid substitutions, A-alpha R16C and gamma G165R. (PubMed id 11435303)1, 2 Bolliger-Stucki B.... Furlan M. (2001)
    10. Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction: a systematic review. (PubMed id 11748101)1, 4 Boekholdt S.M....Peters R.J. (2001)

    External Searches for FGG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FGG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2266 HGNC: 3694 AceView: FGG Ensembl:ENSG00000171557 euGenes: HUgn2266
    ECgene: FGG Kegg: 2266 H-InvDB: FGG

    Other Databases showing FGG gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FGG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGG Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FGG
    Wikipedia http://en.wikipedia.org/wiki/Fibrinogen
    SeattleSNPshttp://pga.gs.washington.edu/data/fgg/

    Intellectual Property
    for FGG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FGG gene:
    Search GeneIP for patents involving FGG

    GeneCards and IP:
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