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FGFRL1 Gene

protein-coding   GIFtS: 59
GCID: GC04P001003

Fibroblast Growth Factor Receptor-Like 1

  See FGFRL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor Receptor-Like 11 2     FHFR2 3
Fibroblast Growth Factor Receptor 52 3     FGF Homologous Factor Receptor2 3
FGFR-52 3     FGF Receptor-Like Protein 12 3
FGFR52 3     FGFR-Like Protein2 3

External Ids:    HGNC: 36931   Entrez Gene: 538342   Ensembl: ENSG000001274187   OMIM: 6058305   UniProtKB: Q8N4413   

Export aliases for FGFRL1 gene to outside databases

Previous GC identifers: GC04M001066 GC04P000994 GC04P000996


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGFRL1 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino
acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one
another in their ligand affinities and tissue distribution. A full-length representative protein would consist of
an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning
segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with
fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis
and differentiation. A marked difference between this gene product and the other family members is its lack of a
cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family
members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same
isoform have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGFRL1 Gene:
FGFRL1 (fibroblast growth factor receptor-like 1) is a protein-coding gene. Diseases associated with FGFRL1 include radioulnar synostosis, and wolf-hirschhorn syndrome. GO annotations related to this gene include heparin binding and fibroblast growth factor-activated receptor activity.

UniProtKB/Swiss-Prot: FGRL1_HUMAN, Q8N441
Function: Has a negative effect on cell proliferation (By similarity)

Gene Wiki entry for FGFRL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006051.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGFRL1 gene promoter:
         SRF   SRF (504 AA)   Nkx2-5   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGFRL1 promoter sequence
   Search Chromatin IP Primers for FGFRL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGFRL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16

FGFRL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGFRL1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P001003:  view genomic region     (about GC identifiers)

Start:
1,003,724 bp from pter      End:
1,020,686 bp from pter
Size:
16,963 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FGRL1_HUMAN, Q8N441 (See protein sequence)
Recommended Name: Fibroblast growth factor receptor-like 1 precursor  
Size: 504 amino acids; 54537 Da
Subunit: Interacts with FGF2 with a low affinity (By similarity)
Secondary accessions: B2RAU9 Q6PJN1 Q9BXN7 Q9H4D7

Explore the universe of human proteins at neXtProt for FGFRL1: NX_Q8N441

Explore proteomics data for FGFRL1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn111, Asn231, Asn255, Asn293
  • Modification sites at PhosphoSitePlus

  • See FGFRL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001004356.1  NP_001004358.1  NP_068742.2  

    ENSEMBL proteins: 
     ENSP00000381498   ENSP00000425025   ENSP00000423091   ENSP00000426740   ENSP00000424037  
     ENSP00000264748  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8N441

    ProtoNet protein and cluster: Q8N441

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: FGRL1_HUMAN, Q8N441
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with FGFRL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGRL1_HUMAN, Q8N441
    Function: Has a negative effect on cell proliferation (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005007fibroblast growth factor-activated receptor activity IDA12813049
    GO:0005515protein binding ----
    GO:0008201heparin binding IDA12813049
    GO:0017134fibroblast growth factor binding IEA--
         
    Find genes that share ontologies with FGFRL1           About GenesLikeMe


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fgfrl1):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size/body  hematopoietic system  homeostasis/metabolism  mortality/aging  muscle 
     nervous system  normal  renal/urinary system  respiratory system  skeleton 

    Find genes that share phenotypes with FGFRL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FGFRL1: Fgfrl1tm1True Fgfrl1tm1.1Ptew

       genOway: Develop your customized and physiologically relevant rodent model for FGFRL1

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    Selected qRT-PCR Assays for microRNAs that regulate FGFRL1 (see all 11):
    hsa-miR-3163 hsa-miR-495 hsa-miR-7-2* hsa-miR-618 hsa-miR-371-5p hsa-miR-4282 hsa-miR-942 hsa-miR-656
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGRL1_HUMAN, Q8N441: Membrane; Single-pass type I membrane protein. Note=Predominantly localized in the plasma
    membrane but also detected in the Golgi and in secretory vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA12813049
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FGFRL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGFRL1 About    
    See pathways by source

    SuperPathContained pathways About
    1VEGF Signaling Pathway
    VEGF Signaling Pathway0.34



    1 PharmGKB Pathway for FGFRL1
        VEGF Signaling Pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FGFRL1
    Interactions:

        Search GeneGlobe Interaction Network for FGFRL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for FGFRL1 (Q8N4413 ENSP000002647484) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGF2P090383, ENSP000002644984I2D: score=2 STRING: ENSP00000264498
    FGF1ENSP000003385484STRING: ENSP00000338548
    EPYCENSP000002611724STRING: ENSP00000261172
    LRRTM1ENSP000002950574STRING: ENSP00000295057
    MUSKENSP000003635714STRING: ENSP00000363571
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0001558regulation of cell growth ----
    GO:0003179heart valve morphogenesis IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0008543fibroblast growth factor receptor signaling pathway IDA12813049

    Find genes that share ontologies with FGFRL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGFRL1 (FGRL1)

    1 Novoseek inferred chemical compound relationship for FGFRL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 28.7 2 11418238 (1), 19056490 (1)



    Find genes that share compounds with FGFRL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGFRL1 gene (3 alternative transcripts): 
    NM_001004356.2  NM_001004358.1  NM_021923.3  

    Unigene Cluster for FGFRL1:

    Fibroblast growth factor receptor-like 1
    Hs.193326  [show with all ESTs]
    Unigene Representative Sequence: AY358303
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512562 ENST00000398484(uc003gce.3) ENST00000510644 ENST00000504138
    ENST00000512174 ENST00000507339 ENST00000264748(uc003gcf.3 uc003gcg.3 uc010ibo.3)

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    hsa-miR-3163 hsa-miR-495 hsa-miR-7-2* hsa-miR-618 hsa-miR-371-5p hsa-miR-4282 hsa-miR-942 hsa-miR-656
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    Additional mRNA sequence: 

    AF279689.1 AF312678.1 AJ277437.1 AK022597.1 AK172829.1 AK225486.1 AK314365.1 AY358303.1 
    BC002537.2 BC013955.2 BC015228.1 BC036769.1 

    11 DOTS entries:

    DT.111737  DT.102826791  DT.95276971  DT.91868466  DT.97816786  DT.121258841  DT.99955648  DT.95276966 
    DT.95276967  DT.95276969  DT.95361017 

    Selected AceView cDNA sequences (see all 157):

    AK022597 AA496510 BC036769 BC002537 CA429575 BM806988 AA477491 BQ952255 
    BM746883 BM770668 C01952 BC015228 BU169023 CA416621 AV707425 BF436316 
    BM561628 BQ689708 AW135378 BM738736 BQ183009 BQ000420 AW083114 BU528897 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FGFRL1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:        -     -     -     -                                                         
    SP2:              -     -     -                                                         
    SP3:                                                                                    
    SP4:                          -                                                         
    SP5:                                                              -                     


    ECgene alternative splicing isoforms for FGFRL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGFRL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGTGCATC
    FGFRL1 Expression
    About this image


    FGFRL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Long Bone
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Distal Renal Vesicle Cells Renal Vesicle
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Chondrocytes Tracheal Cartilage
             Tracheal Cartilage
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Laryngeal Cartilage
    FGFRL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGFRL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.193326

    UniProtKB/Swiss-Prot: FGRL1_HUMAN, Q8N441
    Tissue specificity: Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver,
    kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FGFRL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgfrl11 , 5 fibroblast growth factor receptor-like 11, 5 85.52(n)1
    90.95(a)1
      5 (53.24 cM)5
    1167011  NM_054071.21  NP_473412.11 
     1086942295 
    chicken
    (Gallus gallus)
    Aves FGFRL11 fibroblast growth factor receptor-like 1 72.56(n)
    74.45(a)
      395107  NM_204456.1  NP_989787.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGFRL16
    fibroblast growth factor receptor-like 1
    72(a)
    1 ↔ 1
    GL343622.1(43002-268689)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.179372 Xenopus laevis transcribed sequence with weak similarity to protein refNP_068742.1 (H.sapiens) fibroblast growth factor receptor-like 1 precursor [Homo sapiens] less 74.18(n)    CD361943.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640842 hypothetical protein MGC64084 76.15(n)   393347  AJ574916.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG314316
    --
    23(a)
    1 ↔ 1
    3R(17696406-17699362)
    worm
    (Caenorhabditis elegans)
    Secernentea igcm-41 igcm-4 41.37(n)
    33.15(a)
      180518  NM_075976.4  NP_508377.1 


    ENSEMBL Gene Tree for FGFRL1 (if available)
    TreeFam Gene Tree for FGFRL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGFRL1 gene
    6 SIMAP similar genes for FGFRL1 using alignment to 4 protein entries:     FGRL1_HUMAN (see all proteins):
    FGFR3    CNTN4    BEK    PSG11    K-SAM    FGFR-4

    Find genes that share paralogs with FGFRL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGFRL1 (see all 625)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819411071,2
    --986651(+) ATGGAA/GGCAGG 1 -- int10--------
    rs1114962571,2
    C,F--986685(+) CCCCAG/CGGCAC 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs1504555801,2
    --986721(+) TCCTGG/TCAAGG 1 -- int10--------
    rs1149606581,2
    F--986932(+) AGCCCG/CCTGGG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs2011713851,2
    C--987069(-) TTTTTG/TCCAAA 1 -- int10--------
    rs68278151,2
    C,F,A,H--987259(+) ATGAGC/GTTCCG 1 -- int17Minor allele frequency- G:0.16NS NA CSA WA EA 479
    rs760487881,2
    C,F--987284(+) CCTGGC/TGGCCA 1 -- int14Minor allele frequency- T:0.12CSA WA NA EA 360
    rs131203741,2
    C,F--987324(+) ACTGAC/GGCGTC 1 -- int13Minor allele frequency- G:0.05NA 124
    rs622945231,2
    F--987409(+) AGCCAG/AGGAAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1811319691,2
    --987533(+) CACGCC/TATTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for FGFRL1 (1003724 - 1020686 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FGFRL1 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5397n71CNV Loss21882294
    dgv5396n71CNV Loss21882294
    nsv469998CNV Loss18288195
    dgv5390n71CNV Loss21882294
    nsv878292CNV Loss21882294
    nsv878326CNV Loss21882294
    dgv5391n71CNV Loss21882294
    dgv5395n71CNV Loss21882294
    nsv878325CNV Loss21882294
    esv28049CNV Loss19812545

    Human Gene Mutation Database (HGMD): FGFRL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGFRL1
    DNA2.0 Custom Variant and Variant Library Synthesis for FGFRL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605830    OMIM disorders: --

    2 diseases for FGFRL1:    
    About MalaCards
    radioulnar synostosis    wolf-hirschhorn syndrome

    4 diseases from the University of Copenhagen DISEASES database for FGFRL1:
    Radioulnar synostosis     Wolf-Hirschhorn syndrome     Vesicoureteral reflux     Congenital diaphragmatic hernia

    Find genes that share disorders with FGFRL1           About GenesLikeMe

    Genetic Association Database (GAD): FGFRL1
    Human Genome Epidemiology (HuGE) Navigator: FGFRL1 (5 documents)

    Export disorders for FGFRL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for FGFRL1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with FGFRL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas. (PubMed id 11267671)1, 2, 9 Kim I.... Koh G.Y. (Biochim. Biophys. Acta 2001)
    2. Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. (PubMed id 12813049)1, 2, 9 Trueb B.... Wiedemann M. (J. Biol. Chem. 2003)
    3. Identification of a new fibroblast growth factor receptor, FGFR5. (PubMed id 11418238)1, 2, 9 Sleeman M.... Murison J.G. (Gene 2001)
    4. Examination of FGFRL1 as a candidate gene for diaphragmatic defects at chromosome 4p16.3 shows that Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm. (PubMed id 20024584)1, 4 LopezJimenez N....Slavotinek A.M. (Hum. Genet. 2010)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 53834 HGNC: 3693 AceView: FGFRL1 Ensembl:ENSG00000127418 euGenes: HUgn53834
    ECgene: FGFRL1 H-InvDB: FGFRL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FGFRL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FGFRL1 gene:
    Search GeneIP for patents involving FGFRL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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