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Aliases for FGFRL1 Gene

Aliases for FGFRL1 Gene

  • Fibroblast Growth Factor Receptor-Like 1 2 3
  • Fibroblast Growth Factor Receptor 5 3 4
  • FGF Homologous Factor Receptor 3 4
  • FGF Receptor-Like Protein 1 3 4
  • FGFR-Like Protein 3 4
  • FGFR-5 3 4
  • FGFR5 3 4
  • FHFR 3 4

External Ids for FGFRL1 Gene

Previous GeneCards Identifiers for FGFRL1 Gene

  • GC04M001066
  • GC04P000994
  • GC04P000996

Summaries for FGFRL1 Gene

Entrez Gene Summary for FGFRL1 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGFRL1 Gene

FGFRL1 (Fibroblast Growth Factor Receptor-Like 1) is a Protein Coding gene. Diseases associated with FGFRL1 include wolf-hirschhorn syndrome and radioulnar synostosis. Among its related pathways are VEGF Signaling Pathway. GO annotations related to this gene include heparin binding and fibroblast growth factor-activated receptor activity.

UniProtKB/Swiss-Prot for FGFRL1 Gene

  • Has a negative effect on cell proliferation.

Gene Wiki entry for FGFRL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFRL1 Gene

Genomics for FGFRL1 Gene

Regulatory Elements for FGFRL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FGFRL1 Gene

1,009,936 bp from pter
1,026,898 bp from pter
16,963 bases
Plus strand

Genomic View for FGFRL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGFRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFRL1 Gene

Proteins for FGFRL1 Gene

  • Protein details for FGFRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibroblast growth factor receptor-like 1
    Protein Accession:
    Secondary Accessions:
    • B2RAU9
    • Q6PJN1
    • Q9BXN7
    • Q9H4D7

    Protein attributes for FGFRL1 Gene

    504 amino acids
    Molecular mass:
    54537 Da
    Quaternary structure:
    • Interacts with FGF2 with a low affinity.

neXtProt entry for FGFRL1 Gene

Proteomics data for FGFRL1 Gene at MOPED

Post-translational modifications for FGFRL1 Gene

  • Glycosylation at Asn111, Asn231, Asn255, and Asn293
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFRL1 Gene

Antibody Products

  • R&D Systems Antibodies for FGFRL1 (FGF R5/FGFRL1)

No data available for DME Specific Peptides for FGFRL1 Gene

Domains for FGFRL1 Gene

Gene Families for FGFRL1 Gene

Protein Domains for FGFRL1 Gene

Suggested Antigen Peptide Sequences for FGFRL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FGFRL1: view

Function for FGFRL1 Gene

Molecular function for FGFRL1 Gene

UniProtKB/Swiss-Prot Function:
Has a negative effect on cell proliferation.

Gene Ontology (GO) - Molecular Function for FGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005007 fibroblast growth factor-activated receptor activity IDA 12813049
GO:0005515 protein binding --
GO:0008201 heparin binding IMP 18061161
GO:0017134 fibroblast growth factor binding IEA --
genes like me logo Genes that share ontologies with FGFRL1: view
genes like me logo Genes that share phenotypes with FGFRL1: view

Animal Models for FGFRL1 Gene

MGI Knock Outs for FGFRL1:

Animal Model Products

miRNA for FGFRL1 Gene

miRTarBase miRNAs that target FGFRL1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGFRL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGFRL1 Gene

Localization for FGFRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFRL1 Gene

Membrane; Single-pass type I membrane protein. Note=Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.

Subcellular locations from

Jensen Localization Image for FGFRL1 Gene COMPARTMENTS Subcellular localization image for FGFRL1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA 18061161
GO:0005886 plasma membrane IDA 12813049
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IDA 18061161
GO:0044291 cell-cell contact zone IDA 18061161
genes like me logo Genes that share ontologies with FGFRL1: view

Pathways for FGFRL1 Gene

SuperPathways for FGFRL1 Gene

Superpath Contained pathways
1 VEGF Signaling Pathway
genes like me logo Genes that share pathways with FGFRL1: view

Pathways by source for FGFRL1 Gene

1 PharmGKB pathway for FGFRL1 Gene

Gene Ontology (GO) - Biological Process for FGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0003179 heart valve morphogenesis IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway IEA --
GO:0034446 NOT substrate adhesion-dependent cell spreading IDA 18061161
genes like me logo Genes that share ontologies with FGFRL1: view

Drugs for FGFRL1 Gene

(1) ApexBio Compounds for FGFRL1 Gene

Compound Action Cas Number
LY2874455 FGF/FGFR Inhibitor [1254473-64-7]

(1) Novoseek inferred chemical compound relationships for FGFRL1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 28.7 2
genes like me logo Genes that share compounds with FGFRL1: view

Transcripts for FGFRL1 Gene

Unigene Clusters for FGFRL1 Gene

Fibroblast growth factor receptor-like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGFRL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFRL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - -
SP4: -
SP5: -

Relevant External Links for FGFRL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGFRL1 Gene

mRNA expression in normal human tissues for FGFRL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FGFRL1 Gene

SOURCE GeneReport for Unigene cluster for FGFRL1 Gene Hs.193326

mRNA Expression by UniProt/SwissProt for FGFRL1 Gene

Tissue specificity: Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.
genes like me logo Genes that share expressions with FGFRL1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Expression partners for FGFRL1 Gene

Orthologs for FGFRL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGFRL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FGFRL1 35
  • 88.37 (n)
  • 91.49 (a)
  • 91 (a)
(Canis familiaris)
Mammalia LOC102151155 35
  • 88.26 (n)
  • 89.66 (a)
  • 85 (a)
(Mus musculus)
Mammalia Fgfrl1 35
  • 85.52 (n)
  • 90.95 (a)
Fgfrl1 16
Fgfrl1 36
  • 82 (a)
(Rattus norvegicus)
Mammalia Fgfrl1 35
  • 85.44 (n)
  • 91.18 (a)
(Monodelphis domestica)
Mammalia FGFRL1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia FGFRL1 36
  • 76 (a)
(Gallus gallus)
Aves FGFRL1 35
  • 72.56 (n)
  • 74.45 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia FGFRL1 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfrl1 35
  • 67.62 (n)
  • 72.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17937 35
(Danio rerio)
Actinopterygii fgfrl1a 35
  • 69.46 (n)
  • 70.7 (a)
zgc64084 35
fgfrl1a 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31431 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea igcm-4 35
  • 41.37 (n)
  • 33.15 (a)
igcm-4 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for FGFRL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FGFRL1 Gene

Gene Tree for FGFRL1 (if available)
Gene Tree for FGFRL1 (if available)

Paralogs for FGFRL1 Gene

(6) SIMAP similar genes for FGFRL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FGFRL1: view

No data available for Paralogs for FGFRL1 Gene

Variants for FGFRL1 Gene

Sequence variations from dbSNP and Humsavar for FGFRL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs748650 -- 1,017,296(+) AGGAC(A/G)CTCTT intron-variant
rs748651 -- 1,017,327(+) GAACT(C/T)GGGTA intron-variant
rs935975 -- 1,019,695(+) CCGCC(A/G)TCTCA intron-variant
rs1064838 -- 1,025,884(+) ACACG(C/T)GTGCA utr-variant-3-prime
rs1064839 -- 1,025,909(+) GGACA(C/G)GCACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FGFRL1 Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
dgv5390n71 CNV Loss 21882294
dgv5391n71 CNV Loss 21882294
nsv469998 CNV Loss 18288195
dgv5395n71 CNV Loss 21882294
dgv5396n71 CNV Loss 21882294
dgv5397n71 CNV Loss 21882294
nsv878292 CNV Loss 21882294
nsv822428 CNV Gain 20364138
nsv878310 CNV Loss 21882294
dgv5398n71 CNV Loss 21882294
nsv878315 CNV Loss 21882294
dgv5399n71 CNV Loss 21882294
nsv878317 CNV Loss 21882294
dgv5400n71 CNV Loss 21882294
esv28049 CNV Loss 19812545
nsv878323 CNV Gain 21882294
nsv878324 CNV Gain 21882294
nsv878325 CNV Loss 21882294
nsv878326 CNV Loss 21882294

Relevant External Links for FGFRL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFRL1 Gene

Disorders for FGFRL1 Gene

Relevant External Links for FGFRL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FGFRL1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for FGFRL1 Gene

Publications for FGFRL1 Gene

  1. Identification of a new fibroblast growth factor receptor, FGFR5. (PMID: 11418238) Sleeman M. … Murison J.G. (Gene 2001) 3 4 23
  2. Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. (PMID: 12813049) Trueb B. … Wiedemann M. (J. Biol. Chem. 2003) 3 4 23
  3. A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas. (PMID: 11267671) Kim I. … Koh G.Y. (Biochim. Biophys. Acta 2001) 3 4 23
  4. Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. (PMID: 11031111) Wiedemann M. … Trueb B. (Genomics 2000) 3 4
  5. Characterization of the first FGFRL1 mutation identified in a craniosynostosis patient. (PMID: 19056490) Rieckmann T. … Trueb B. (Biochim. Biophys. Acta 2009) 3 23

Products for FGFRL1 Gene

Sources for FGFRL1 Gene

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