Aliases for FGFRL1 Gene
External Ids for FGFRL1 Gene
Previous GeneCards Identifiers for FGFRL1 Gene
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGFRL1 Gene
FGFRL1 (Fibroblast Growth Factor Receptor-Like 1) is a Protein Coding gene. Diseases associated with FGFRL1 include Wolf-Hirschhorn Syndrome. Among its related pathways are MAPK Signaling: Mitogen Stimulation Pathway and mTOR signaling pathway (KEGG). GO annotations related to this gene include heparin binding and fibroblast growth factor-activated receptor activity.
UniProtKB/Swiss-Prot for FGFRL1 Gene
Has a negative effect on cell proliferation.