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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGFRL1 Gene

protein-coding   GIFtS: 57
GCID: GC04P001003

fibroblast growth factor receptor-like 1
 Explore 10 diseases affiliated with
FGFRL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FGFRL1    

Aliases
for FGFRL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fibroblast Growth Factor Receptor-Like 11 2     FHFR2 3
Fibroblast Growth Factor Receptor 52 3     FGF Homologous Factor Receptor2 3
FGFR-52 3     FGF Receptor-Like Protein 12 3
FGFR52 3     FGFR-Like Protein2 3

External Ids:    HGNC: 36931   Entrez Gene: 538342   Ensembl: ENSG000001274187   OMIM: 6058305   UniProtKB: Q8N4413   

Export aliases for FGFRL1 gene to outside databases

Previous GC identifers: GC04M001066 GC04P000994 GC04P000996


Summaries
for FGFRL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FGFRL1:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid
sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in
their ligand affinities and tissue distribution. A full-length representative protein would consist of an
extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment
and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth
factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A
marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase
domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit
signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FGRL1_HUMAN, Q8N441
Function: Has a negative effect on cell proliferation (By similarity)

Gene Wiki entry for FGFRL1


Genomic Views
for FGFRL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_037622.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGFRL1 gene promoter:
         SRF   SRF (504 AA)   Nkx2-5   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGFRL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGFRL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGFRL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16

FGFRL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGFRL1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P001003:  view genomic region     (about GC identifiers)

Start:
 1,003,724 bp from pter      End:
 1,020,686 bp from pter
Size:
 16,963 bases      Orientation:
 plus strand

Proteins
for FGFRL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FGRL1_HUMAN, Q8N441 (See protein sequence)
Recommended Name: Fibroblast growth factor receptor-like 1 precursor  
Size: 504 amino acids; 54537 Da
Subunit: Interacts with FGF2 with a low affinity (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein. Note=Predominantly localized in the plasma
membrane but also detected in the Golgi and in secretory vesicles
Secondary accessions: B2RAU9 Q6PJN1 Q9BXN7 Q9H4D7

Explore the universe of human proteins at neXtProt for FGFRL1: NX_Q8N441

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N441

    • FGFRL1 Protein expression data from MOPED and PaxDb:    About this image 
    FGFRL1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001004356.1  NP_001004358.1  NP_068742.2  

    ENSEMBL proteins: 
     ENSP00000381498   ENSP00000425025   ENSP00000423091   ENSP00000426740   ENSP00000424037  
     ENSP00000264748  

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    Novus Biologicals FGFRL1 Proteins
    Sino Biological Recombinant Protein for FGFRL1
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    Uscn Proteins for FGFRL1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA12813049
    GO:0016021integral to membrane IEA--

    FGFRL1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FGFRL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FGFRL1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8N441

    ProtoNet protein and cluster: Q8N441

    2 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: FGRL1_HUMAN, Q8N441
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for FGFRL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGRL1_HUMAN, Q8N441
    Function: Has a negative effect on cell proliferation (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005007fibroblast growth factor-activated receptor activity IDA12813049
    GO:0008201heparin binding IDA12813049
    GO:0017134fibroblast growth factor binding IEA--
         
    FGFRL1 for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fgfrl1):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size  hematopoietic system  homeostasis/metabolism  mortality/aging  muscle 
     nervous system  normal  renal/urinary system  respiratory system  skeleton 

    FGFRL1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for FGFRL1: Fgfrl1tm1True Fgfrl1tm1.1Ptew
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FGFRL1 

    miRNA
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    hsa-miR-3163 hsa-miR-495 hsa-miR-7-2* hsa-miR-618 hsa-miR-371-5p hsa-miR-4282 hsa-miR-942 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmid: FGFRL1 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: FGFRL1
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FGFRL1 
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for FGFRL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FGFRL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for FGFRL1 (Q8N4413 ENSP000002647484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGF2P090383, ENSP000002644984I2D: score=2 STRING: ENSP00000264498
    FGF1ENSP000003385484STRING: ENSP00000338548
    FGFR2ENSP000004102944STRING: ENSP00000410294
    FGFR3ENSP000002607954STRING: ENSP00000260795
    FGFR1ENSP000003802804STRING: ENSP00000380280
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0001558regulation of cell growth NAS--
    GO:0003179heart valve morphogenesis IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0008543fibroblast growth factor receptor signaling pathway IDA12813049

    FGFRL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FGFRL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGFRL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGFRL1
    1 Novoseek chemical compound relationship for FGFRL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 28.7 2 11418238 (1), 19056490 (1)

    Search CenterWatch for drugs/clinical trials and news about FGFRL1 / FGRL1 

    Transcripts
    for FGFRL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FGFRL1 gene (3 alternative transcripts): 
    NM_001004356.2  NM_001004358.1  NM_021923.3  

    Unigene Cluster for FGFRL1:

    Fibroblast growth factor receptor-like 1
    Hs.193326  [show with all ESTs]
    Unigene Representative Sequence: AY358303
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512562 ENST00000398484(uc003gce.3) ENST00000510644 ENST00000504138
    ENST00000512174 ENST00000507339 ENST00000264748(uc003gcf.3 uc003gcg.3 uc010ibo.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGFRL1
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate FGFRL1 (see all 11):
    hsa-miR-3163 hsa-miR-495 hsa-miR-7-2* hsa-miR-618 hsa-miR-371-5p hsa-miR-4282 hsa-miR-942 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmid: FGFRL1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGFRL1 (see all 7)
    OriGene shRNA RFP: FGFRL1
    OriGene siRNA: FGFRL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGFRL1
    Sirion Biotech Custom design and validation of potent shRNA sequences against FGFRL1 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGFRL1 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): FGFRL1 (NM_001004356)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGFRL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGFRL1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGFRL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGFRL1

    Additional cDNA sequence: 

    AF279689.1 AF312678.1 AJ277437.1 AK022597.1 AK172829.1 AK225486.1 AK314365.1 AY358303.1 
    BC002537.2 BC013955.2 BC015228.1 BC036769.1 

    11 DOTS entries:

    DT.111737  DT.102826791  DT.95276971  DT.91868466  DT.97816786  DT.121258841  DT.99955648  DT.95276966 
    DT.95276967  DT.95276969  DT.95361017 

    24/157 AceView cDNA sequences (see all 157):

    AA496510 NM_001004358 BQ183009 BC002537 BQ952255 AW083114 BM806988 BQ924530 
    AK172829 BU528897 BQ186722 BM738736 AA479851 AA477491 C01952 CA416621 
    AW135378 BQ689708 BU169023 BQ879072 AV707425 BQ000420 NM_021923 BM746883 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FGFRL1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:        -     -     -     -                                                         
    SP2:              -     -     -                                                         
    SP3:                                                                                    
    SP4:                          -                                                         
    SP5:                                                              -                     


    ECgene alternative splicing isoforms for FGFRL1

    Expression
    for FGFRL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGFRL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGTGCATC
    FGFRL1 Expression
    About this image

    FGFRL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal VesicleDistal Renal Vesicle CellsKidney
    KidneyRenal VesicleProximal Renal Vesicle CellsKidney
    KidneyS-shaped Body Distal SegmentS-shaped Body Distal CellsKidney
    KidneyS-shaped Body Medial SegmentS-shaped Body Medial CellsKidney
    KidneyS-shaped Body Proximal SegmentS-shaped Body Proximal CellsKidney
    LungTracheal CartilageChondrocytesLung
    BoneAutopod Long BoneBone
    BoneEndochondral Facial BonesBone
    BoneStylopod Long BoneBone
    BoneThoracic RibBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FGFRL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGFRL1

    SOURCE GeneReport for Unigene cluster: Hs.193326

    UniProtKB/Swiss-Prot: FGRL1_HUMAN, Q8N441
    Tissue specificity: Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver,
    kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen

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    In Situ
    Assay Products:     
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    Orthologs
    for FGFRL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FGFRL1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fgfrl11 , 5 fibroblast growth factor receptor-like 11, 5 85.04(n)1
    89.98(a)1    		   5 (53.24 cM)5
    1167011  NM_054071.21  NP_473412.11 
     1086942295 
    chicken
    (Gallus gallus)    		 Aves FGFRL11 fibroblast growth factor receptor-like 1 72.16(n)
    73.49(a)    		   395107  NM_204456.1  NP_989787.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FGFRL16
    --
    		 --
    		 72(a)
    31(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343622.1(46694-268686)
    GL343520.1(474612-477123)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.179372 Xenopus laevis transcribed sequence with weak similarity more 74.18(n)    CD361943.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc640842 hypothetical protein MGC64084 76.15(n)   393347  AJ574916.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG314316
    		 --
    		 20(a)
    		 1 ↔ 1
    		 3R(17696406-17699362)
    worm
    (Caenorhabditis elegans)    		 Secernentea igcm-41 Protein IGCM-4 41.71(n)
    33.33(a)    		   180518  NM_075976.3  NP_508377.1 


    ENSEMBL Gene Tree for FGFRL1 (if available)
    TreeFam Gene Tree for FGFRL1 (if available) 

    Paralogs
    for FGFRL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for FGFRL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/403 NCBI SNPs in FGFRL1 are shown (see all 403)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs45697071,2
    		C,F,A--1003788(+) GCCACC/GTTTCC 2 -- us2k19Minor allele frequency- G:0.27NA CSA WA EA 368
    rs1885335941,2
    		--1003896(+) CTCCCA/GCGGGC 2 -- us2k10--------
    rs1813458441,2
    		--1004090(+) GCGGGA/GGCAGG 2 -- us2k10--------
    rs1133954641,2
    		--1004192(+) CAGCAC/GCTTGG 2 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs1413063741,2
    		--1004208(+) CCGGGA/TAGTTC 2 -- us2k10--------
    rs1450728231,2
    		--1004229(+) GAGTCC/TCACAC 2 -- us2k10--------
    rs1127325121,2
    		--1004257(+) CCCACG/ACCCCG 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1404702371,2
    		--1004343(+) AAGAGA/GGGGCT 3 -- us2k10--------
    rs774885131,2
    		--1004351(+) GCTTCA/TGGCCC 3 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs343443801,2
    		C--1004359(-) TCTTTA/CTGGGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for FGFRL1 (1003724 - 1020686 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for FGFRL1
         4 CNVs: 30190 30189 68596 30188
    Human Gene Mutation Database (HGMD): FGFRL1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGFRL1
    DNA2.0 Custom Variant and Variant Library Synthesis for FGFRL1

    Disorders / Diseases
    for FGFRL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FGFRL1 for disorders           About GeneDecksing

    OMIM gene information: 605830    OMIM disorders: --

    10 diseases for FGFRL1:    About MalaCards
    antley-bixler syndrome    wolf-hirschhorn syndrome    radioulnar synostosis    congenital diaphragmatic hernia
    vesicoureteral reflux    synostosis    hernia    craniosynostosis
    esophagitis    adenocarcinoma

    4 diseases from the University of Copenhagen DISEASES database for FGFRL1:
    Radioulnar synostosis     Wolf-Hirschhorn syndrome     Vesicoureteral reflux     Congenital diaphragmatic hernia
    Human Genome Epidemiology (HuGE) Navigator: FGFRL1 (5 documents)

    Export disorders for FGFRL1 gene to outside databases

    Publications
    for FGFRL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGFRL1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with FGFRL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas. (PubMed id 11267671)1, 2, 9 Kim I.... Koh G.Y. (2001)
    2. Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. (PubMed id 12813049)1, 2, 9 Trueb B.... Wiedemann M. (2003)
    3. Identification of a new fibroblast growth factor receptor, FGFR5. (PubMed id 11418238)1, 2, 9 Sleeman M.... Murison J.G. (2001)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. (PubMed id 11031111)1, 2 Wiedemann M. and Trueb B. (2000)
    9. Characterization of the first FGFRL1 mutation identified in a craniosynostosis patient. (PubMed id 19056490)1, 9 Rieckmann T....Trueb B. (2009)
    10. Interaction of the receptor FGFRL1 with the negative regulator Spred1. (PubMed id 21616146)1 Zhuang L....Trueb B. (2011)

    External Searches for FGFRL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FGFRL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53834 HGNC: 3693 AceView: FGFRL1 Ensembl:ENSG00000127418 euGenes: HUgn53834
    ECgene: FGFRL1 H-InvDB: FGFRL1

    Other Databases showing FGFRL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FGFRL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGFRL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FGFRL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FGFRL1 gene:
    Search GeneIP for patents involving FGFRL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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