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Aliases for FGFRL1 Gene

Aliases for FGFRL1 Gene

  • Fibroblast Growth Factor Receptor-Like 1 2 3 5
  • Fibroblast Growth Factor Receptor 5 3 4
  • FGF Homologous Factor Receptor 3 4
  • FGF Receptor-Like Protein 1 3 4
  • FGFR-Like Protein 3 4
  • FGFR-5 3 4
  • FGFR5 3 4
  • FHFR 3 4

External Ids for FGFRL1 Gene

Previous GeneCards Identifiers for FGFRL1 Gene

  • GC04M001066
  • GC04P000994
  • GC04P000996

Summaries for FGFRL1 Gene

Entrez Gene Summary for FGFRL1 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGFRL1 Gene

FGFRL1 (Fibroblast Growth Factor Receptor-Like 1) is a Protein Coding gene. Diseases associated with FGFRL1 include Wolf-Hirschhorn Syndrome. Among its related pathways are VEGF Signaling Pathway and mTOR signaling pathway (KEGG). GO annotations related to this gene include heparin binding and fibroblast growth factor-activated receptor activity.

UniProtKB/Swiss-Prot for FGFRL1 Gene

  • Has a negative effect on cell proliferation.

Gene Wiki entry for FGFRL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFRL1 Gene

Genomics for FGFRL1 Gene

Regulatory Elements for FGFRL1 Gene

Enhancers for FGFRL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F001014 0.7 ENCODE 20 +5.1 5055 1.3 BCOR CTCF TFAP4 SAP130 ARID4B ZMYM3 RAD21 ZIC2 ZNF335 GLIS2 FGFRL1 SLC26A1 CRIPAK GC04M001024
GH04F000921 0.9 FANTOM5 Ensembl ENCODE 18.5 -86.4 -86363 4.5 HDGF KLF1 TBL1XR1 NFXL1 EBF1 ZIC2 ZBTB40 RELA ZNF121 GLIS2 FGFRL1 DGKQ SLC26A1 GAK PCGF3 PIGG TMEM175 UVSSA ZNF721 GC04M000897
GH04F001288 0.4 ENCODE 10.5 +280.1 280094 3.5 PKNOX1 ATF1 ARID4B SIN3A ZNF48 ETS1 YY1 GLIS2 ZNF143 FOS MAEA UVSSA HAUS3 CTBP1 CTBP1-AS2 SPON2 FGFRL1 GC04M001299
GH04F001020 1.3 Ensembl ENCODE 8.7 +10.2 10165 1.0 GATAD2A SRF KLF1 TFAP4 ZBTB8A REST PPARG ZNF48 HIC1 GLIS2 UVSSA FGFRL1 ENSG00000251639 GC04M001024
GH04F000929 1 FANTOM5 ENCODE 7.8 -78.3 -78323 3.5 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF143 ZNF207 ZNF263 SP3 DGKQ CRIPAK GAK PCGF3 FGFRL1 SLC26A1 UVSSA MAEA MFSD7 IDUA
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FGFRL1 on UCSC Golden Path with GeneCards custom track

Promoters for FGFRL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001682790 1064 3601 HDGF PKNOX1 ZFP64 SIN3A ARID4B ZNF48 GLIS2 CBX5 FOS ZNF263

Genomic Location for FGFRL1 Gene

Chromosome:
4
Start:
1,009,936 bp from pter
End:
1,026,898 bp from pter
Size:
16,963 bases
Orientation:
Plus strand

Genomic View for FGFRL1 Gene

Genes around FGFRL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFRL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFRL1 Gene

Proteins for FGFRL1 Gene

  • Protein details for FGFRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N441-FGRL1_HUMAN
    Recommended name:
    Fibroblast growth factor receptor-like 1
    Protein Accession:
    Q8N441
    Secondary Accessions:
    • B2RAU9
    • Q6PJN1
    • Q9BXN7
    • Q9H4D7

    Protein attributes for FGFRL1 Gene

    Size:
    504 amino acids
    Molecular mass:
    54537 Da
    Quaternary structure:
    • Interacts with FGF2 with a low affinity.

neXtProt entry for FGFRL1 Gene

Post-translational modifications for FGFRL1 Gene

  • Glycosylation at Asn 111, Asn 231, Asn 255, and Asn 293
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for FGFRL1 (FGF R5/FGFRL1)
  • Abcam antibodies for FGFRL1
  • Cloud-Clone Corp. Antibodies for FGFRL1

No data available for DME Specific Peptides for FGFRL1 Gene

Domains & Families for FGFRL1 Gene

Gene Families for FGFRL1 Gene

Suggested Antigen Peptide Sequences for FGFRL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N441

UniProtKB/Swiss-Prot:

FGRL1_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FGFRL1: view

Function for FGFRL1 Gene

Molecular function for FGFRL1 Gene

UniProtKB/Swiss-Prot Function:
Has a negative effect on cell proliferation.

Gene Ontology (GO) - Molecular Function for FGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005007 fibroblast growth factor-activated receptor activity IDA 12813049
GO:0008201 heparin binding IMP 18061161
GO:0017134 fibroblast growth factor binding IEA --
genes like me logo Genes that share ontologies with FGFRL1: view
genes like me logo Genes that share phenotypes with FGFRL1: view

Animal Models for FGFRL1 Gene

MGI Knock Outs for FGFRL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGFRL1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGFRL1 Gene

Localization for FGFRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFRL1 Gene

Membrane; Single-pass type I membrane protein. Note=Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGFRL1 Gene COMPARTMENTS Subcellular localization image for FGFRL1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
endoplasmic reticulum 2
extracellular 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA 18061161
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IDA 18061161
genes like me logo Genes that share ontologies with FGFRL1: view

Pathways & Interactions for FGFRL1 Gene

genes like me logo Genes that share pathways with FGFRL1: view

Pathways by source for FGFRL1 Gene

1 PharmGKB pathway for FGFRL1 Gene

Gene Ontology (GO) - Biological Process for FGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0003179 heart valve morphogenesis IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0034446 NOT substrate adhesion-dependent cell spreading IDA 18061161
genes like me logo Genes that share ontologies with FGFRL1: view

No data available for SIGNOR curated interactions for FGFRL1 Gene

Drugs & Compounds for FGFRL1 Gene

(2) Drugs for FGFRL1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LY2874455 Pharma FGF/FGFR Inhibitor 0

(1) ApexBio Compounds for FGFRL1 Gene

Compound Action Cas Number
LY2874455 FGF/FGFR Inhibitor 1254473-64-7
genes like me logo Genes that share compounds with FGFRL1: view

Transcripts for FGFRL1 Gene

Unigene Clusters for FGFRL1 Gene

Fibroblast growth factor receptor-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFRL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - -
SP3:
SP4: -
SP5: -

Relevant External Links for FGFRL1 Gene

GeneLoc Exon Structure for
FGFRL1
ECgene alternative splicing isoforms for
FGFRL1

Expression for FGFRL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGFRL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGFRL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FGFRL1 Gene:

FGFRL1

SOURCE GeneReport for Unigene cluster for FGFRL1 Gene:

Hs.193326

mRNA Expression by UniProt/SwissProt for FGFRL1 Gene:

Q8N441-FGRL1_HUMAN
Tissue specificity: Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.
genes like me logo Genes that share expression patterns with FGFRL1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for FGFRL1 Gene

Orthologs for FGFRL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGFRL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGFRL1 34 35
  • 88.37 (n)
dog
(Canis familiaris)
Mammalia LOC102151155 34
  • 88.26 (n)
FGFRL1 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgfrl1 34 16 35
  • 85.52 (n)
rat
(Rattus norvegicus)
Mammalia Fgfrl1 34
  • 85.44 (n)
oppossum
(Monodelphis domestica)
Mammalia FGFRL1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGFRL1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGFRL1 34 35
  • 72.56 (n)
lizard
(Anolis carolinensis)
Reptilia FGFRL1 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfrl1 34
  • 67.62 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17937 34
zebrafish
(Danio rerio)
Actinopterygii fgfrl1a 34 35
  • 69.46 (n)
zgc64084 34
fruit fly
(Drosophila melanogaster)
Insecta CG31431 35
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea igcm-4 34 35
  • 41.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToOne
Species where no ortholog for FGFRL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FGFRL1 Gene

ENSEMBL:
Gene Tree for FGFRL1 (if available)
TreeFam:
Gene Tree for FGFRL1 (if available)

Paralogs for FGFRL1 Gene

(6) SIMAP similar genes for FGFRL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FGFRL1: view

No data available for Paralogs for FGFRL1 Gene

Variants for FGFRL1 Gene

Sequence variations from dbSNP and Humsavar for FGFRL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1064838 -- 1,025,884(+) ACACG(C/T)GTGCA utr-variant-3-prime
rs1064839 -- 1,025,909(+) GGACA(C/T)GCACA utr-variant-3-prime
rs111216247 -- 1,020,912(+) GGGGC(A/G)GGGCT intron-variant
rs111246053 -- 1,024,966(+) TGGCC(C/T)GTGGT reference, synonymous-codon
rs111348090 -- 1,011,597(+) GGGTC(-/G)GGGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FGFRL1 Gene

Variant ID Type Subtype PubMed ID
dgv2703n106 CNV deletion 24896259
esv28049 CNV loss 19812545
nsv1003219 CNV gain 25217958
nsv1008352 CNV gain 25217958
nsv1073282 CNV deletion 25765185
nsv1120469 CNV tandem duplication 24896259
nsv1133572 CNV deletion 24896259
nsv469998 CNV loss 18288195
nsv593226 CNV loss 21841781
nsv593228 CNV loss 21841781
nsv593231 CNV gain 21841781
nsv593233 CNV loss 21841781
nsv593234 CNV loss 21841781
nsv593235 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv822428 CNV gain 20364138
nsv950328 CNV deletion 24416366

Variation tolerance for FGFRL1 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGFRL1 Gene

Human Gene Mutation Database (HGMD)
FGFRL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGFRL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFRL1 Gene

Disorders for FGFRL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FGFRL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
wolf-hirschhorn syndrome
  • 4p deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FGFRL1

Genetic Association Database (GAD)
FGFRL1
Human Genome Epidemiology (HuGE) Navigator
FGFRL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGFRL1
genes like me logo Genes that share disorders with FGFRL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGFRL1 Gene

Publications for FGFRL1 Gene

  1. Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. (PMID: 12813049) Trueb B. … Wiedemann M. (J. Biol. Chem. 2003) 3 4 22 64
  2. Identification of a new fibroblast growth factor receptor, FGFR5. (PMID: 11418238) Sleeman M. … Murison J.G. (Gene 2001) 3 4 22 64
  3. A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas. (PMID: 11267671) Kim I. … Koh G.Y. (Biochim. Biophys. Acta 2001) 3 4 22 64
  4. Examination of FGFRL1 as a candidate gene for diaphragmatic defects at chromosome 4p16.3 shows that Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm. (PMID: 20024584) LopezJimenez N. … Slavotinek A.M. (Hum. Genet. 2010) 3 46 64
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64

Products for FGFRL1 Gene

Sources for FGFRL1 Gene

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