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Aliases for FGFR4 Gene

Aliases for FGFR4 Gene

  • Fibroblast Growth Factor Receptor 4 2 3
  • EC 2.7.10.1 4 63
  • JTK2 3 4
  • TKF 3 4
  • Tyrosine Kinase Related To Fibroblast Growth Factor Receptor 3
  • Hydroxyaryl-Protein Kinase 3
  • Protein-Tyrosine Kinase 3
  • Tyrosylprotein Kinase 3
  • CD334 Antigen 4
  • EC 2.7.10 63
  • FGFR-4 4
  • CD334 3

External Ids for FGFR4 Gene

Summaries for FGFR4 Gene

Entrez Gene Summary for FGFR4 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGFR4 Gene

FGFR4 (Fibroblast Growth Factor Receptor 4) is a Protein Coding gene. Diseases associated with FGFR4 include achondroplasia and breast fibroadenoma. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include heparin binding and fibroblast growth factor binding. An important paralog of this gene is FGFR3.

UniProtKB/Swiss-Prot for FGFR4 Gene

  • Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Tocris Summary for FGFR4 Gene

  • Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans (HSGAGs), which facilitates dimerization (activation) of FGF receptors (FGFRs). FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. There are four human genes encoding FGFRs, which produce seven different receptors (FGFR1b, FGFR1c, FGFR2b, FGFR2c, FGFR3b, FGFR3c and FGFR4) due to alternative splicing events occurring both in the extracellular and intracellular regions. The alternative splice isoforms are generally tissue specific: the b isoform is expressed in epithelial tissue, whereas the c isoform is expressed in mesenchymal tissue. HSGAG-FGF-FGFR binding initiates FGFR dimerization, enabling the cytoplasmic kinase domains to transphosphorylate tyrosine residues and become activated. HSGAGs also function to stabilize FGF-FGFR binding and prevent FGF degradation. FGFRs couple to the PLCgamma, MAPK and PI3-K/Akt intracellular signaling cascades and there is evidence of cross talk with the Notch signaling pathway. In addition, some activated FGF-FGFR complexes are endocytosed and function directly in the cytosol and/or nucleus of the cell. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer.

Gene Wiki entry for FGFR4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFR4 Gene

Genomics for FGFR4 Gene

Genomic Location for FGFR4 Gene

Start:
177,086,886 bp from pter
End:
177,098,144 bp from pter
Size:
11,259 bases
Orientation:
Plus strand

Genomic View for FGFR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGFR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFR4 Gene

Regulatory Elements for FGFR4 Gene

Proteins for FGFR4 Gene

  • Protein details for FGFR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22455-FGFR4_HUMAN
    Recommended name:
    Fibroblast growth factor receptor 4
    Protein Accession:
    P22455
    Secondary Accessions:
    • G3JVM2
    • G3JVM5
    • G3JVM7
    • G3JVM9
    • O43785
    • Q14309
    • Q71TW8
    • Q8TDA0
    • Q96KE5

    Protein attributes for FGFR4 Gene

    Size:
    802 amino acids
    Molecular mass:
    87954 Da
    Quaternary structure:
    • Monomer. Homodimer after ligand binding. Interacts with FGF1, FGF2, FGF4, FGF6, FGF8, FGF9, FGF16, FGF17, FGF18, FGF19, FGF21 and FGF23 (in vitro). Binding affinity for FGF family members is enhanced by interactions between FGFs and heparan sulfate proteoglycans. Interacts with KLB; this strongly increases the affinity for FGF19 and FGF23. Affinity for FGF19 is strongly increased by KLB and sulfated glycosaminoglycans. KLB and KL both interact with the core-glycosylated FGFR4 in the endoplasmic reticulum and promote its degradation, so that only FGFR4 with fully mature N-glycans is expressed at the cell surface. Identified in a complex with NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with MMP14 and HIP1.

    Three dimensional structures from OCA and Proteopedia for FGFR4 Gene

    Alternative splice isoforms for FGFR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGFR4 Gene

Proteomics data for FGFR4 Gene at MOPED

Post-translational modifications for FGFR4 Gene

  • Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer.
  • N-glycosylated. Full maturation of the glycan chains in the Golgi is essential for high affinity interaction with FGF19
  • Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn112, Asn258, Asn290, Asn311, and Asn322

Domains for FGFR4 Gene

Gene Families for FGFR4 Gene

Suggested Antigen Peptide Sequences for FGFR4 Gene

Graphical View of Domain Structure for InterPro Entry

P22455

UniProtKB/Swiss-Prot:

FGFR4_HUMAN
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • P22455
  • Contains 1 protein kinase domain.:
    • P22455
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.:
    • P22455
genes like me logo Genes that share domains with FGFR4: view

Function for FGFR4 Gene

Molecular function for FGFR4 Gene

GENATLAS Biochemistry: fibroblast growth factor receptor 4,involved in the development of endoderm derivatives and in skeletal muscle formation
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues.
UniProtKB/Swiss-Prot Function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Enzyme Numbers (IUBMB) for FGFR4 Gene

Gene Ontology (GO) - Molecular Function for FGFR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005007 fibroblast growth factor-activated receptor activity IGI 10525310
GO:0005515 protein binding IPI 17627937
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with FGFR4: view
genes like me logo Genes that share phenotypes with FGFR4: view

Animal Models for FGFR4 Gene

MGI Knock Outs for FGFR4:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for FGFR4 Gene

Localization for FGFR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFR4 Gene

Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.
Isoform 2: Secreted.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGFR4 Gene COMPARTMENTS Subcellular localization image for FGFR4 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
extracellular 5
plasma membrane 5
nucleus 4
cytosol 2
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FGFR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with FGFR4: view

Pathways for FGFR4 Gene

SuperPathways for FGFR4 Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 PI-3K cascade
3 Signaling by FGFR
4 FGFR ligand binding and activation
5 GPCR Pathway
genes like me logo Genes that share pathways with FGFR4: view

Pathways by source for FGFR4 Gene

Gene Ontology (GO) - Biological Process for FGFR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001759 organ induction IEA --
GO:0006468 protein phosphorylation --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008284 positive regulation of cell proliferation IGI 8663044
GO:0008286 insulin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FGFR4: view

Compounds for FGFR4 Gene

(13) ApexBio Compounds for FGFR4 Gene

Compound Action Cas Number
AP26113 Dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). [1197958-12-5]
AZD4547 Potent, selective, and ATP-competitive FGFR inhibitor [1035270-39-3]
BGJ398 FGFR inhibitor [872511-34-7]
Danusertib (PHA-739358) Pan-aurora kinase inhibitor [827318-97-8]
Dovitinib (TKI-258, CHIR-258) novel multitargeted growth factor receptor kinase inhibitor of FLT3, c-KIT, FGFR1/3, VEGFR1/2/3 [405169-16-6]
E-3810 novel dual inhibitor targeting VEGFRs and FGFRs [1058137-23-7]
Fenretinide synthetic retinoid deriverative. [65646-68-6]
LY2874455 novel and potent FGF/FGFR Inhibitor. [1254473-64-7]
Nintedanib (BIBF 1120) Multi-target kinase inhibitor, inhibits VEGFR, PDGFR, and FGFR [928326-83-4]
Pazopanib (GW-786034) Multi-target kinase inhibitor, inhibits VEGFR, PDGFR, and FGFR [635702-64-6]
PD 173074 Potent, ATP-competitive, and reversible FGFR inhibitor [219580-11-7]
Ponatinib (AP24534) pan-BCR-ABL inhibitor [943319-70-8]
SKLB610 Potent VEGFR inhibitor [1125780-41-7]

(4) Tocris Compounds for FGFR4 Gene

Compound Action Cas Number
FIIN 1 hydrochloride Potent, irreversible FGFR inhibitor [1256152-35-8]
PD 161570 Selective FGFR inhibitor [192705-80-9]
PD 173074 FGFR1 and -3 inhibitor [219580-11-7]
SU 5402 Potent FGFR and VEGFR inhibitor [215543-92-3]

(2) HMDB Compounds for FGFR4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) Drugbank Compounds for FGFR4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Palifermin
  • FGF-7
162394-19-6 target
Ponatinib
943319-70-8 target inhibitor

(11) Novoseek inferred chemical compound relationships for FGFR4 Gene

Compound -log(P) Hits PubMed IDs
pd 173074 85.8 1
tyrosine 60 22
heparan sulfate 45.3 3
phosphotyrosine 32.3 1
chenodeoxycholic acid 31.1 1
genes like me logo Genes that share compounds with FGFR4: view

Transcripts for FGFR4 Gene

Unigene Clusters for FGFR4 Gene

Fibroblast growth factor receptor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGFR4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - - - -
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 12d ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FGFR4 Gene

GeneLoc Exon Structure for
FGFR4
ECgene alternative splicing isoforms for
FGFR4

Expression for FGFR4 Gene

mRNA expression in normal human tissues for FGFR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGFR4 Gene

This gene is overexpressed in Liver (8.8), Lung (7.6), Kidney - Cortex (5.4), and Pancreas (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FGFR4 Gene

SOURCE GeneReport for Unigene cluster for FGFR4 Gene Hs.165950

mRNA Expression by UniProt/SwissProt for FGFR4 Gene

P22455-FGFR4_HUMAN
Tissue specificity: Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
genes like me logo Genes that share expressions with FGFR4: view

Orthologs for FGFR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGFR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGFR4 35
  • 99.11 (n)
  • 98.9 (a)
FGFR4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGFR4 35
  • 89.48 (n)
  • 93.13 (a)
FGFR4 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGFR4 35
  • 89.45 (n)
  • 93.01 (a)
FGFR4 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgfr4 35
  • 85.51 (n)
  • 90.72 (a)
Fgfr4 16
Fgfr4 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGFR4 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGFR4 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgfr4 35
  • 85.26 (n)
  • 90.75 (a)
chicken
(Gallus gallus)
Aves FGFR4 35
  • 74.47 (n)
  • 72.81 (a)
FGFR4 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGFR4 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397701 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfr4 35
  • 65.47 (n)
  • 69.01 (a)
zebrafish
(Danio rerio)
Actinopterygii fgfr4 35
  • 63.91 (n)
  • 66.1 (a)
fgfr4 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta btl 36
  • 27 (a)
ManyToMany
htl 36
  • 37 (a)
ManyToMany
btl 37
  • 37 (a)
tor 37
  • 52 (a)
htl 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-15 36
  • 25 (a)
OneToMany
old-2 37
  • 36 (a)
ver-4 37
  • 33 (a)
ver-2 37
  • 39 (a)
R151.4 37
  • 38 (a)
R09D1.13 37
  • 33 (a)
kin-16 37
  • 36 (a)
kin-9 37
  • 38 (a)
F09G2.1 37
  • 32 (a)
C24G6.2a 37
  • 35 (a)
Y38H6C.20 37
  • 32 (a)
old-1 37
  • 36 (a)
R09D1.12 37
  • 32 (a)
W04G5.10 37
  • 38 (a)
Y50D4B.6 37
  • 34 (a)
kin-23 37
  • 34 (a)
C24G6.2b 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for FGFR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FGFR4 Gene

ENSEMBL:
Gene Tree for FGFR4 (if available)
TreeFam:
Gene Tree for FGFR4 (if available)

Paralogs for FGFR4 Gene

Paralogs for FGFR4 Gene

genes like me logo Genes that share paralogs with FGFR4: view

Variants for FGFR4 Gene

Sequence variations from dbSNP and Humsavar for FGFR4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs9489 -- 177,098,028(+) CCCCA(C/G)CGTCT utr-variant-3-prime
rs31776 -- 177,096,596(-) GGAGG(C/T)AGGGC intron-variant, downstream-variant-500B
rs31777 -- 177,096,561(-) CTCCC(G/T)ACGAC intron-variant, downstream-variant-500B
rs31778 -- 177,095,035(-) AGAGA(A/G)GGGAA intron-variant
rs42409 -- 177,095,727(-) CGCCT(A/G)TACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGFR4 Gene

Variant ID Type Subtype PubMed ID
dgv363n21 CNV Gain 19592680
nsv509101 CNV Insertion 20534489
nsv883156 CNV Loss 21882294
nsv883157 CNV Loss 21882294
nsv823351 CNV Gain 20364138
nsv482093 CNV Gain 20164927
nsv521574 CNV Loss 19592680
esv24424 CNV Loss 19812545
esv2657291 CNV Deletion 23128226

Relevant External Links for FGFR4 Gene

HapMap Linkage Disequilibrium report
FGFR4
Human Gene Mutation Database (HGMD)
FGFR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFR4 Gene

Disorders for FGFR4 Gene

(1) University of Copenhagen DISEASES for FGFR4 Gene

(27) Novoseek inferred disease relationships for FGFR4 Gene

Disease -log(P) Hits PubMed IDs
pituitary tumors 48.7 8
aggressiveness 41.7 2
breast cancer 38.9 21
cancer 34.1 19
hnscc 32.6 4

Relevant External Links for FGFR4

Genetic Association Database (GAD)
FGFR4
Human Genome Epidemiology (HuGE) Navigator
FGFR4
Tumor Gene Database (TGDB):
FGFR4
genes like me logo Genes that share disorders with FGFR4: view

No data available for UniProtKB/Swiss-Prot for FGFR4 Gene

Publications for FGFR4 Gene

  1. FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. (PMID: 1709094) Partanen J.M. … Alitalo K. (EMBO J. 1991) 3 4 23
  2. Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor. (PMID: 7680645) Ron D. … Tronick S.R. (J. Biol. Chem. 1993) 3 4 23
  3. Genomic structure and complete sequence of the human FGFR4 gene. (PMID: 9457674) Kostrzewa M. … Muller U. (Mamm. Genome 1998) 3 4 23
  4. Identification of a novel alternative splicing of human FGF receptor 4: soluble-form splice variant expressed in human gastrointestinal epithelial cells. (PMID: 10631118) Takaishi S. … Chiba T. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  5. Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis. (PMID: 11781352) Ezzat S. … Asa S.L. (J. Clin. Invest. 2002) 3 4 23

Products for FGFR4 Gene

Sources for FGFR4 Gene

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