Free for academic non-profit institutions. Other users need a Commercial license

FGFR4 Gene(Protein Coding)

Fibroblast Growth Factor Receptor 4

GCID:
GC05P177086
GIFtS:
75
Genes Participants
UDN Logo

Aliases for FGFR4 Gene

Aliases for FGFR4 Gene

  • Fibroblast Growth Factor Receptor 4 2 3 5
  • EC 2.7.10.1 4 61
  • JTK2 3 4
  • TKF 3 4
  • Tyrosine Kinase Related To Fibroblast Growth Factor Receptor 3
  • Hydroxyaryl-Protein Kinase 3
  • Protein-Tyrosine Kinase 3
  • Tyrosylprotein Kinase 3
  • CD334 Antigen 4
  • EC 2.7.10 61
  • FGFR-4 4
  • CD334 3

External Ids for FGFR4 Gene

Previous GeneCards Identifiers for FGFR4 Gene

  • GC05P176887
  • GC05P177356
  • GC05P176449
  • GC05P176494
  • GC05P176446
  • GC05P176513
  • GC05P171435

Summaries for FGFR4 Gene

Entrez Gene Summary for FGFR4 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGFR4 Gene

FGFR4 (Fibroblast Growth Factor Receptor 4) is a Protein Coding gene. Diseases associated with FGFR4 include Prostate Cancer and Neuroma. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGFR3.

UniProtKB/Swiss-Prot for FGFR4 Gene

  • Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Tocris Summary for FGFR4 Gene

  • Fibroblast growth factors (FGFs) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGF receptors (FGFRs) are transmembrane catalytic receptors with intracellular tyrosine kinase activity.

Gene Wiki entry for FGFR4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFR4 Gene

Genomics for FGFR4 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FGFR4 Gene

Enhancers for FGFR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G177093 1.8 FANTOM5 Ensembl ENCODE dbSUPER 72.1 +10.7 10686 8.4 ARID4B DMAP1 ZNF48 YY1 ZNF121 GLIS2 FOS PAF1 ZNF263 SP5 FGFR4 RAB24 RGS14 NSD1
GH05G177085 1.4 Ensembl ENCODE 59 +1.3 1318 5.2 HDGF HNRNPUL1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 FGFR4 RAB24 LMAN2 NSD1
GH05G177108 1.4 ENCODE dbSUPER 22.6 +23.0 22975 1.9 HDGF HNRNPUL1 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 FGFR4 NSD1 PRELID1 RAB24 MXD3 RGS14 TSPAN17
GH05G176895 1.3 Ensembl ENCODE dbSUPER 12.2 -187.8 -187844 7.7 CTCF ZNF146 ZSCAN26 NFIB RAD21 ZIC2 ZBTB40 FOXK2 POLR2A EED ZNF346 FGFR4 UNC5A ZNF346-IT1 UIMC1 HK3 GC05M176812
GH05G177105 0.8 dbSUPER 18.5 +19.0 18968 1.4 MLX NFIB ARID4B DMAP1 ZNF121 KAT8 ZNF579 NFIC ZNF341 CEBPA FGFR4 RAB24 RGS14 PRELID1 NSD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGFR4 on UCSC Golden Path with GeneCards custom track

Promoters for FGFR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000191295 128 801 HDGF HNRNPUL1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1
ENSR00000318781 1028 201 PAF1 SMARCA5 ATF1 ZMYM3 ZBTB33 RBFOX2 YY1

Transcription factor binding sites by QIAGEN in the FGFR4 gene promoter:

Genomic Location for FGFR4 Gene

Chromosome:
5
Start:
177,086,872 bp from pter
End:
177,098,144 bp from pter
Size:
11,273 bases
Orientation:
Plus strand

Genomic View for FGFR4 Gene

Genes around FGFR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFR4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FGFR4 Gene

Proteins for FGFR4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FGFR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22455-FGFR4_HUMAN
    Recommended name:
    Fibroblast growth factor receptor 4
    Protein Accession:
    P22455
    Secondary Accessions:
    • G3JVM2
    • G3JVM5
    • G3JVM7
    • G3JVM9
    • O43785
    • Q14309
    • Q71TW8
    • Q8TDA0
    • Q96KE5

    Protein attributes for FGFR4 Gene

    Size:
    802 amino acids
    Molecular mass:
    87954 Da
    Quaternary structure:
    • Monomer. Homodimer after ligand binding. Interacts with FGF1, FGF2, FGF4, FGF6, FGF8, FGF9, FGF16, FGF17, FGF18, FGF19, FGF21 and FGF23 (in vitro). Binding affinity for FGF family members is enhanced by interactions between FGFs and heparan sulfate proteoglycans. Interacts with KLB; this strongly increases the affinity for FGF19 and FGF23. Affinity for FGF19 is strongly increased by KLB and sulfated glycosaminoglycans. KLB and KL both interact with the core-glycosylated FGFR4 in the endoplasmic reticulum and promote its degradation, so that only FGFR4 with fully mature N-glycans is expressed at the cell surface. Identified in a complex with NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with MMP14 and HIP1 (PubMed:11433297, PubMed:16597617, PubMed:17623664, PubMed:18670643, PubMed:20683963, PubMed:20798051, PubMed:21653700, PubMed:7518429, PubMed:8663044). Interacts with STAT3 (PubMed:26675719).

    Three dimensional structures from OCA and Proteopedia for FGFR4 Gene

    Alternative splice isoforms for FGFR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGFR4 Gene

Protein Expression for FGFR4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for FGFR4 Gene

P22455:
  • WEIFTLGGSP
  • RDLAARN
  • NIINLLG
  • WSLVMES
  • MRECWHA
  • LGKPLGEGCFGQV
  • VAVKMLK
  • LPVKWMA
  • EDAGEYTCLAGNSIG
  • SEVEVLYL
  • EALFDRVYT
  • SAWLTVL
  • VMKIADFGLAR
  • LRARRPP
  • IDYYKKT
  • PSQRPTFKQLVE
  • MESVVPSD
  • AARNVLV
  • PHIQWLK
  • GILLWEIF
  • CIHRDLAARNVLV
  • WEFPRDRL
  • CKVYSDAQPH
  • PILQAGLPAN
  • PVKWMAPE
  • YTHQSDVWS
  • LDVLERS
  • YTCLVEN
  • GPLYVIVE
  • ERSPHRPILQAGLP

Post-translational modifications for FGFR4 Gene

  • Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer.
  • N-glycosylated. Full maturation of the glycan chains in the Golgi is essential for high affinity interaction with FGF19.
  • Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated.
  • Glycosylation at Asn112, isoforms=2, 3258, Asn290, Asn311, and isoforms=2, 3322
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FGFR4 (FGFR4)
  • Cloud-Clone Corp. Antibodies for FGFR4
  • Santa Cruz Biotechnology (SCBT) Antibodies for FGFR4

Domains & Families for FGFR4 Gene

Gene Families for FGFR4 Gene

HGNC:
IUPHAR :

Protein Domains for FGFR4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FGFR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22455

UniProtKB/Swiss-Prot:

FGFR4_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
genes like me logo Genes that share domains with FGFR4: view

Function for FGFR4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FGFR4 Gene

GENATLAS Biochemistry:
fibroblast growth factor receptor 4,involved in the development of endoderm derivatives and in skeletal muscle formation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Enzyme Numbers (IUBMB) for FGFR4 Gene

Gene Ontology (GO) - Molecular Function for FGFR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA,TAS --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0005007 fibroblast growth factor-activated receptor activity IGI,IDA 10525310
genes like me logo Genes that share ontologies with FGFR4: view
genes like me logo Genes that share phenotypes with FGFR4: view

Animal Models for FGFR4 Gene

MGI Knock Outs for FGFR4:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGFR4

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGFR4 Gene

Localization for FGFR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFR4 Gene

Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.
Isoform 2: Secreted.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFR4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 5
nucleus 4
cytosol 3
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FGFR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IDA,IEA 20683963
GO:0005794 Golgi apparatus IDA 18061161
genes like me logo Genes that share ontologies with FGFR4: view

Pathways & Interactions for FGFR4 Gene

SuperPathways for FGFR4 Gene

PathCards logo More details on SuperPathways for FGFR4
SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
NCAM signaling for neurite out-growth
.89
DAP12 interactions
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.56
2 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
3 Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR4
.81
FRS-mediated FGFR4 signaling
.81
betaKlotho-mediated ligand binding
.01
FGFR4 ligand binding and activation
.01
FGFR4 mutant receptor activation
.01
Phospholipase C-mediated cascade; FGFR4
.01
PI-3K cascade-FGFR4
.01
SHC-mediated cascade-FGFR4
.01
Signaling by FGFR4 in disease
.01
4 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
5 GAB1 signalosome
Negative regulation of the PI3K/AKT network
.93
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
.93
PIP3 activates AKT signaling
.91
Role of LAT2/NTAL/LAB on calcium mobilization
.91
GAB1 signalosome
.89
PI3K/AKT activation
.89
Constitutive Signaling by Aberrant PI3K in Cancer
.75
PI3K/AKT Signaling in Cancer
.72
genes like me logo Genes that share pathways with FGFR4: view

SIGNOR curated interactions for FGFR4 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FGFR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006468 protein phosphorylation IEA --
GO:0008284 positive regulation of cell proliferation IGI 8663044
GO:0008543 fibroblast growth factor receptor signaling pathway TAS,IDA --
GO:0010628 positive regulation of gene expression IMP 19085950
genes like me logo Genes that share ontologies with FGFR4: view

Drugs & Compounds for FGFR4 Gene

Products:

  1. Drug

(37) Drugs for FGFR4 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palifermin Approved Pharma binder, Target 0
Lenvatinib Approved Pharma Target, Inhibitor Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 62
ponatinib Approved Pharma Target, inhibitor Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors 32
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2935
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1856

(8) Additional Compounds for FGFR4 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
FIIN 1 hydrochloride
1256152-35-8
SUN 11602
704869-38-5

(4) Tocris Compounds for FGFR4 Gene

Compound Action Cas Number
FIIN 1 hydrochloride Potent, irreversible FGFR inhibitor 1256152-35-8
PD 161570 Selective FGFR inhibitor 192705-80-9
PD 173074 FGFR1 and -3 inhibitor 219580-11-7
SUN 11602 Basic fibroblast growth factor (bFGF) mimetic; neuroprotective 704869-38-5

(11) ApexBio Compounds for FGFR4 Gene

Compound Action Cas Number
ACTB-1003 939805-30-8
AZD4547 FGFR inhibitor 1035270-39-3
BGJ398 FGFR inhibitor ,potent and selective 872511-34-7
BLU9931 FGFR4 inhibitor,potent and irreversible 1538604-68-0
CH5183284 (Debio-1347) 1265229-25-1
LY2874455 FGF/FGFR Inhibitor 1254473-64-7
NVP-BGJ398 phosphate FGFR inhibitor 1310746-10-1
Pazopanib Hydrochloride VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor 635702-64-6
PD 161570 192705-80-9
PD 173074 FGFR inhibitor 219580-11-7
Vandetanib (ZD6474) VEGFR2/EGFR antagonist 443913-73-3
genes like me logo Genes that share compounds with FGFR4: view

Transcripts for FGFR4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FGFR4 Gene

(7) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(182) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGFR4 Gene

Fibroblast growth factor receptor 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFR4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - - - -
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 12d ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FGFR4 Gene

GeneLoc Exon Structure for
FGFR4
ECgene alternative splicing isoforms for
FGFR4

Expression for FGFR4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGFR4 Gene

mRNA expression in normal human tissues for FGFR4 Gene
mRNA expression by BioGPS for FGFR4 GenemRNA expression by GTEx for FGFR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGFR4 Gene

This gene is overexpressed in Liver (x8.8), Lung (x7.6), Kidney - Cortex (x5.4), and Pancreas (x4.0).

Protein differential expression in normal tissues from HIPED for FGFR4 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGFR4 Gene



Protein tissue co-expression partners for FGFR4 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGFR4 Gene:

FGFR4

SOURCE GeneReport for Unigene cluster for FGFR4 Gene:

Hs.165950

mRNA Expression by UniProt/SwissProt for FGFR4 Gene:

P22455-FGFR4_HUMAN
Tissue specificity: Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.

Evidence on tissue expression from TISSUES for FGFR4 Gene

  • Muscle(4.7)
  • Intestine(4.5)
  • Liver(4.5)
  • Nervous system(4.4)
  • Blood(4.3)
  • Lung(2.4)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with FGFR4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFR4 Gene

Orthologs for FGFR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGFR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FGFR4 34 35
  • 99.11 (n)
cow
(Bos Taurus)
 Mammalia FGFR4 34 35
  • 89.48 (n)
dog
(Canis familiaris)
 Mammalia FGFR4 34 35
  • 89.45 (n)
mouse
(Mus musculus)
 Mammalia Fgfr4 34 16 35
  • 85.51 (n)
rat
(Rattus norvegicus)
 Mammalia Fgfr4 34
  • 85.26 (n)
oppossum
(Monodelphis domestica)
 Mammalia FGFR4 35
  • 78 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia FGFR4 35
  • 55 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FGFR4 34 35
  • 74.47 (n)
lizard
(Anolis carolinensis)
 Reptilia FGFR4 35
  • 67 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fgfr4 34
  • 65.47 (n)
African clawed frog
(Xenopus laevis)
 Amphibia LOC397701 34
zebrafish
(Danio rerio)
 Actinopterygii fgfr4 34 35
  • 63.91 (n)
fruit fly
(Drosophila melanogaster)
 Insecta tor 36
  • 52 (a)
htl 36 35
  • 40 (a)
btl 36 35
  • 37 (a)
worm
(Caenorhabditis elegans)
 Secernentea ver-2 36
  • 39 (a)
kin-9 36
  • 38 (a)
R151.4 36
  • 38 (a)
W04G5.10 36
  • 38 (a)
kin-16 36
  • 36 (a)
old-1 36
  • 36 (a)
old-2 36
  • 36 (a)
C24G6.2a 36
  • 35 (a)
C24G6.2b 36
  • 35 (a)
kin-23 36
  • 34 (a)
Y50D4B.6 36
  • 34 (a)
R09D1.13 36
  • 33 (a)
ver-4 36
  • 33 (a)
F09G2.1 36
  • 32 (a)
R09D1.12 36
  • 32 (a)
Y38H6C.20 36
  • 32 (a)
egl-15 35
  • 25 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 41 (a)
 OneToMany
Species where no ortholog for FGFR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FGFR4 Gene

ENSEMBL:
Gene Tree for FGFR4 (if available)
TreeFam:
Gene Tree for FGFR4 (if available)

Paralogs for FGFR4 Gene

Paralogs for FGFR4 Gene

(69) SIMAP similar genes for FGFR4 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FGFR4: view

Variants for FGFR4 Gene

Sequence variations from dbSNP and Humsavar for FGFR4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs351855 Pathogenic, Prostate cancer (PC) [MIM:176807] 177,093,242(-) CAGCC(C/T)GGCCA intron-variant, nc-transcript-variant, reference, missense
VAR_046104 A lung adenocarcinoma sample
VAR_046105 A lung neuroendocrine carcinoma sample
rs483352775 Uncertain significance 177,095,586(+) AGTTC(C/T)TGCGG nc-transcript-variant, reference, synonymous-codon
rs1000336443 -- 177,091,329(+) GGAGA(A/G)GAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGFR4 Gene

Variant ID Type Subtype PubMed ID
dgv363n21 CNV gain 19592680
esv24424 CNV loss 19812545
esv2657291 CNV deletion 23128226
esv3607685 CNV loss 21293372
nsv482093 CNV gain 20164927
nsv509101 CNV insertion 20534489
nsv521574 CNV loss 19592680
nsv823351 CNV gain 20364138

Variation tolerance for FGFR4 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.38; 94.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGFR4 Gene

Human Gene Mutation Database (HGMD)
FGFR4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGFR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFR4 Gene

Disorders for FGFR4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FGFR4 Gene - From: Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
neuroma
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search FGFR4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGFR4_HUMAN
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:18670643, ECO:0000269 PubMed:18756523, ECO:0000269 PubMed:20876804, ECO:0000269 PubMed:21349172}. Note=The gene represented in this entry is involved in disease pathogenesis. FGFR4 variant Arg-388 has been associated with prostate cancer as well as cancers of the breast, colon, head and neck, larynx, lung, skin. Arg-388 predisposes cancer patients for accelerated disease progression and is associated with poor prognosis. {ECO:0000269 PubMed:11781352, ECO:0000269 PubMed:11830541, ECO:0000269 PubMed:18670643, ECO:0000269 PubMed:18756523, ECO:0000269 PubMed:20638838, ECO:0000269 PubMed:20876804, ECO:0000269 PubMed:21349172, ECO:0000269 PubMed:21412156, ECO:0000269 PubMed:21882254, ECO:0000269 PubMed:26675719}.

Relevant External Links for FGFR4

Genetic Association Database (GAD)
FGFR4
Human Genome Epidemiology (HuGE) Navigator
FGFR4
Tumor Gene Database (TGDB):
FGFR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGFR4
genes like me logo Genes that share disorders with FGFR4: view

No data available for Genatlas for FGFR4 Gene

Publications for FGFR4 Gene

  1. Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population. (PMID: 18756523) Ma Z. … Habuchi T. (Int. J. Cancer 2008) 3 4 22 46 64
  2. Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. (PMID: 11830541) Bange J. … Ullrich A. (Cancer Res. 2002) 3 4 22 46 64
  3. FGFR4 Gly388Arg polymorphism and prostate cancer risk in Scottish men. (PMID: 19918264) Ho C.K. … Habib F.K. (Prostate Cancer Prostatic Dis. 2010) 3 22 46 64
  4. FGFR4 polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma. (PMID: 20127014) Tanuma J. … Kitano M. (Oncol. Rep. 2010) 3 22 46 64
  5. Polymorphism of FGFR4 in cancer development and sensitivity to cisplatin and radiation in head and neck cancer. (PMID: 18487077) Ansell A. … Thunell L.K. (Oral Oncol. 2009) 3 22 46 64

Products for FGFR4 Gene

  • Cloud-Clone Corp. Antibodies for FGFR4
  • Cloud-Clone Corp. Proteins for FGFR4
  • Cloud-Clone Corp Assay Kits for FGFR4
  • Addgene plasmids for FGFR4

Sources for FGFR4 Gene

Content
Loading form....