Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FGFR4 Gene

protein-coding   GIFtS: 75
GCID: GC05P176513

Fibroblast Growth Factor Receptor 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fibroblast Growth Factor Receptor 41 2     Hydroxyaryl-Protein Kinase2
FGFR-42 3     Protein-Tyrosine Kinase2
JTK22 3     Tyrosine Kinase Related To Fibroblast Growth Factor Receptor2
TKF2 3     Tyrosylprotein Kinase2
EC 2.7.10.13 8     CD334 Antigen3
CD3342     EC 2.7.108

External Ids:    HGNC: 36911   Entrez Gene: 22642   Ensembl: ENSG000001608677   OMIM: 1349355   UniProtKB: P224553   

Export aliases for FGFR4 gene to outside databases

Previous GC identifers: GC05P176887 GC05P177356 GC05P176449 GC05P176494 GC05P176446 GC05P171435


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FGFR4 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid
sequence is highly conserved between members and throughout evolution. FGFR family members differ from one
another in their ligand affinities and tissue distribution. A full-length representative protein would consist of
an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning
segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with
fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis
and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather
than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of
the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This
particular family member preferentially binds acidic fibroblast growth factor and, although its specific function
is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian
tumorigenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGFR4 Gene:
FGFR4 (fibroblast growth factor receptor 4) is a protein-coding gene. Diseases associated with FGFR4 include cancer progression/metastasis, and achondroplasia. GO annotations related to this gene include fibroblast growth factor binding and heparin binding. An important paralog of this gene is FLT4.

UniProtKB/Swiss-Prot: FGFR4_HUMAN, P22455
Function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a
role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid
metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for
normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response
to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades.
Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol
1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates
activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling
pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4
signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and
degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation
lead to aberrant signaling

summary for FGFR4 Gene:
Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles
in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind
heparan sulfate glycosaminoglycans (HSGAGs), which facilitates dimerization (activation) of FGF receptors
(FGFRs). FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. There
are four human genes encoding FGFRs, which produce seven different receptors (FGFR1b, FGFR1c, FGFR2b,
FGFR2c, FGFR3b, FGFR3c and FGFR4) due to alternative splicing events occurring both in the extracellular and
intracellular regions. The alternative splice isoforms are generally tissue specific: the b isoform is
expressed in epithelial tissue, whereas the c isoform is expressed in mesenchymal tissue. HSGAG-FGF-FGFR
binding initiates FGFR dimerization, enabling the cytoplasmic kinase domains to transphosphorylate tyrosine
residues and become activated. HSGAGs also function to stabilize FGF-FGFR binding and prevent FGF
degradation. FGFRs couple to the PLCgamma, MAPK and PI3-K/Akt intracellular signaling cascades and there is
evidence of cross talk with the Notch signaling pathway. In addition, some activated FGF-FGFR complexes are
endocytosed and function directly in the cytosol and/or nucleus of the cell. Mutations in FGFR genes are the
cause of several human developmental disorders characterized by skeletal abnormalities such as
achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer.

Gene Wiki entry for FGFR4 (Fibroblast growth factor receptor 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGFR4 gene promoter:
         AREB6   ER-alpha   AhR   AML1a   SEF-1 (1)   AP-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGFR4 promoter sequence
   Search Chromatin IP Primers for FGFR4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGFR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

FGFR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGFR4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P176513:  view genomic region     (about GC identifiers)

Start:
176,513,887 bp from pter      End:
176,525,145 bp from pter
Size:
11,259 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FGFR4_HUMAN, P22455 (See protein sequence)
Recommended Name: Fibroblast growth factor receptor 4 precursor  
Size: 802 amino acids; 87954 Da
Subunit: Monomer. Homodimer after ligand binding. Interacts with FGF1, FGF2, FGF4, FGF6, FGF8, FGF9, FGF16, FGF17,
FGF18, FGF19, FGF21 and FGF23 (in vitro). Binding affinity for FGF family members is enhanced by interactions
between FGFs and heparan sulfate proteoglycans. Interacts with KLB; this strongly increases the affinity for
FGF19 and FGF23. Affinity for FGF19 is strongly increased by KLB and sulfated glycosaminoglycans. KLB and KL both
interact with the core-glycosylated FGFR4 in the endoplasmic reticulum and promote its degradation, so that only
FGFR4 with fully mature N-glycans is expressed at the cell surface. Identified in a complex with NCAM1, CDH2,
PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with MMP14 and HIP1
1 PDB 3D structure from and Proteopedia for FGFR4:
1QCT (3D)    
Secondary accessions: G3JVM2 G3JVM5 G3JVM7 G3JVM9 O43785 Q14309 Q71TW8 Q8TDA0 Q96KE5
Alternative splicing: 3 isoforms:  P22455-1   P22455-2   P22455-3   (Lacks a signal peptide. Constitutively phosphorylated)

Explore the universe of human proteins at neXtProt for FGFR4: NX_P22455

Explore proteomics data for FGFR4 at MOPED

Post-translational modifications: 

  • N-glycosylated. Full maturation of the glycan chains in the Golgi is essential for high affinity interaction with
    FGF191
  • Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated1
  • Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes
    receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between
    the two FGFR molecules present in the dimer1
  • Glycosylation2 at Asn112, Asn258, Asn290, Asn311, Asn322
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FGFR4 (P22455) (see all 30)
     RDLAARN  PHIQWLK  NIINLLG  WSLVMES 


    See FGFR4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_002002.3  NP_075252.2  NP_998812.1  

    ENSEMBL proteins: 
     ENSP00000292408   ENSP00000424905   ENSP00000377259   ENSP00000426492   ENSP00000424960  
     ENSP00000427222   ENSP00000422889   ENSP00000377254   ENSP00000395164   ENSP00000424670  
     ENSP00000292410  
    Reactome Protein details: P22455

    FGFR4 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant FGFR4 Protein
    R&D Systems Recombinant & Natural Proteins for FGFR4 (FGF R4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FGFR4
    OriGene Protein Over-expression Lysate for FGFR4
    OriGene MassSpec for FGFR4
    OriGene Custom Protein Services for FGFR4
    GenScript Custom Purified and Recombinant Proteins Services for FGFR4
    Novus Biologicals FGFR4 Proteins
    Novus Biologicals FGFR4 Lysates
    Sino Biological Recombinant Protein for FGFR4
    Sino Biological Cell Lysate for FGFR4
    ProSpec Recombinant Protein for FGFR4
    Cloud-Clone Corp. Proteins for FGFR4

    FGFR4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FGFR4 (FGF R4)
    Cell Signaling Technology (CST) Antibodies for FGFR4 
    OriGene Antibodies for FGFR4
    OriGene Custom Antibody Services for FGFR4
    Novus Biologicals FGFR4 Antibodies
    Abcam antibodies for FGFR4
    Cloud-Clone Corp. Antibodies for FGFR4
    ThermoFisher Antibodies for FGFR4
    LSBio Antibodies in human, mouse, rat for FGFR4

    FGFR4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FGFR4
    R&D Systems ELISAs for FGFR4 (FGF R4)         (see all)
    GenScript FGFR4-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGFR4
    Cloud-Clone Corp. CLIAs for FGFR4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: fibroblast growth factor receptor 4
    FGF (fibroblast growth factor) receptor family
    FGF (fibroblast growth factor) receptor family

    Selected InterPro protein domains (see all 11):
     IPR003598 Ig_sub2
     IPR017441 Protein_kinase_ATP_BS
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom
     IPR016248 FGF_rcpt_fam

    Graphical View of Domain Structure for InterPro Entry P22455

    ProtoNet protein and cluster: P22455

    3 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: FGFR4_HUMAN, P22455
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor
    receptor subfamily
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    FGFR4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGFR4_HUMAN, P22455
    Function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a
    role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid
    metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for
    normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response
    to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades.
    Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol
    1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates
    activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling
    pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4
    signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and
    degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation
    lead to aberrant signaling
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to
    dimerization and activation by autophosphorylation on tyrosine residues

         Genatlas biochemistry entry for FGFR4:
    fibroblast growth factor receptor 4,involved in the development of endoderm derivatives and in skeletal muscle
    formation

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0005007fibroblast growth factor-activated receptor activity IGI10525310
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    FGFR4 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for FGFR4:
     Cells with protrusions  Decreased telomerase activity  Increased HPV18 LCR reporter a  Increased cell death HMECs cel 
     Increased cell number in G1, s  Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fgfr4):
     cellular  growth/size/body  homeostasis/metabolism  mortality/aging  reproductive system 
     respiratory system  tumorigenesis 

    FGFR4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fgfr4tm1Cxd for FGFR4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGFR4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGFR4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGFR4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGFR4

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat FGFR4 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate FGFR4:
    hsa-miR-3163 hsa-miR-607 hsa-miR-3613-3p hsa-miR-205* hsa-miR-32* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidFGFR4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FGFR4
    Predesigned siRNA for gene silencing in human, mouse, rat FGFR4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FGFR4

    Clone
    Products:
         
    OriGene clones in human, mouse for FGFR4 (see all 18)
    OriGene ORF clones in mouse, rat for FGFR4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FGFR4 (NM_002011)
    Sino Biological Human cDNA Clone for FGFR4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGFR4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGFR4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FGFR4
    Browse ESI BIO Cell Lines and PureStem Progenitors for FGFR4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGFR4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FGFR4_HUMAN, P22455: Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum.
    Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane
    FGFR4_HUMAN, P22455: Isoform 2: Secreted
    FGFR4_HUMAN, P22455: Isoform 3: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    extracellular5
    plasma membrane5
    nucleus4
    cytosol2
    cytoskeleton1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IEA--

    FGFR4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FGFR4 About   (see all 40)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    Klotho-mediated ligand binding0.00
    SHC-mediated cascade0.79
    FGFR4 ligand binding and activation0.00
    FRS2-mediated cascade0.70
    betaKlotho-mediated ligand binding0.00
    Negative regulation of FGFR signaling0.56
    Signaling by FGFR4 mutants0.00
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Actin-Based Motility by Rho Family GTPases0.62
    Apoptotic Pathways in Synovial Fibroblasts0.84
    ERK5 Signaling0.61
    p53 Mediated Apoptosis0.84
    eIF2 Pathway0.60
    4PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FGFR4
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGFR4 (see all 60)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for FGFR4
        Angiogenesis
    Tyrosine Kinases / Adaptors

    3 Tocris Bioscience Pathways for FGFR4
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway

    1 GeneGo (Thomson Reuters) Pathway for FGFR4
        Development FGF-family signaling

    2 BioSystems Pathways for FGFR4
        Regulation of Actin Cytoskeleton
    FGF signaling pathway


    Selected Reactome Pathways for FGFR4 (see all 12)
        Signaling by FGFR mutants
    Signaling by FGFR4 mutants
    PI3K Cascade
    betaKlotho-mediated ligand binding
    Phospholipase C-mediated cascade

    2 PharmGKB Pathways for FGFR4
        VEGF Signaling Pathway
    Vemurafenib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for FGFR4) (see all 6):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Endocytosis
    PI3K-Akt signaling pathway


    FGFR4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGFR4: 
              Stem Cell Signaling in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGFR4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGFR4 (P224553 ENSP000002924084) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDH2P190223, ENSP000002691414I2D: score=2 STRING: ENSP00000269141
    FGF4P086203, ENSP000001687124I2D: score=2 STRING: ENSP00000168712
    PLCG1P191743, ENSP000002440074I2D: score=2 STRING: ENSP00000244007
    STAT1P422243, ENSP000003543944I2D: score=2 STRING: ENSP00000354394
    FGF18O760933, ENSP000002746254I2D: score=1 STRING: ENSP00000274625
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001759organ induction IEA--
    GO:0006468protein phosphorylation ----
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008284positive regulation of cell proliferation IGI8663044
    GO:0008286insulin receptor signaling pathway TAS--

    FGFR4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for FGFR4 (see all 13)     About this table
    CompoundAction CAS #
    AP26113Dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR)[1197958-12-5]
    AZD4547Potent, selective, and ATP-competitive FGFR inhibitor[1035270-39-3]
    BGJ398FGFR inhibitor [872511-34-7]
    Danusertib (PHA-739358)Pan-aurora kinase inhibitor[827318-97-8]
    Dovitinib (TKI-258, CHIR-258)novel multitargeted growth factor receptor kinase inhibitor of FLT3, c-KIT, FGFR1/3, VEGFR1/2/3[405169-16-6]
    E-3810novel dual inhibitor targeting VEGFRs and FGFRs[1058137-23-7]
    Fenretinidesynthetic retinoid deriverative. [65646-68-6]
    LY2874455novel and potent FGF/FGFR Inhibitor. [1254473-64-7]
    Nintedanib (BIBF 1120)Multi-target kinase inhibitor, inhibits VEGFR, PDGFR, and FGFR[928326-83-4]
    Pazopanib (GW-786034)Multi-target kinase inhibitor, inhibits VEGFR, PDGFR, and FGFR[635702-64-6]

    Compounds for FGFR4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PD 161570Selective FGFR inhibitor[192705-80-9]
    PD 173074FGFR1 and -3 inhibitor[219580-11-7]
    FIIN 1 hydrochloride Potent, irreversible FGFR inhibitor [1256152-35-8]
    SU 5402Potent FGFR and VEGFR inhibitor[215543-92-3]

    2 HMDB Compounds for FGFR4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for FGFR4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    PaliferminFGF-7 (see all 5)162394-19-6target--10950949 11149756 9755102 9843417 7526860
    Ponatinib -- 943319-70-8targetinhibitor23468082

    Selected Novoseek inferred chemical compound relationships for FGFR4 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 173074 85.8 1 19008009 (1)
    tyrosine 60 27 8576110 (2), 9334263 (1), 7774576 (1), 9010226 (1) (see all 21)
    heparan sulfate 45.3 3 10336501 (1), 8227197 (1), 11278860 (1)
    phosphotyrosine 32.3 1 11830541 (1)
    chenodeoxycholic acid 31.1 1 19085950 (1)
    heparin 29.7 17 7774576 (7), 11278860 (2), 10336501 (1), 10736564 (1) (see all 5)
    phosphatidylinositol 27.5 1 15377668 (1)
    arginine 19.9 13 19918264 (2), 17084840 (1), 18756523 (1), 15448004 (1) (see all 8)
    paraffin 14.5 1 11271786 (1)
    cholesterol 0 3 15750181 (2)



    FGFR4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FGFR4 gene (3 alternative transcripts): 
    NM_002011.3  NM_022963.2  NM_213647.1  

    Unigene Cluster for FGFR4:

    Fibroblast growth factor receptor 4
    Hs.165950  [show with all ESTs]
    Unigene Representative Sequence: AB209631
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000292408(uc003mfl.3 uc003mfm.3 uc011dfu.2) ENST00000503708
    ENST00000393648 ENST00000514472 ENST00000502906 ENST00000510911 ENST00000507708
    ENST00000513166 ENST00000393637 ENST00000430285(uc011dfv.1) ENST00000426612(uc003mfn.1)
    ENST00000509511(uc011dfw.1) ENST00000508139 ENST00000511076 ENST00000483872
    ENST00000513423 ENST00000292410(uc003mfo.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FGFR4 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate FGFR4:
    hsa-miR-3163 hsa-miR-607 hsa-miR-3613-3p hsa-miR-205* hsa-miR-32* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidFGFR4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FGFR4
    Predesigned siRNA for gene silencing in human, mouse, rat FGFR4
    Clone
    Products:
         
    OriGene clones in human, mouse for FGFR4 (see all 18)
    OriGene ORF clones in mouse, rat for FGFR4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FGFR4 (NM_002011)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGFR4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGFR4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FGFR4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGFR4
      QuantiTect SYBR Green Assays in human, mouse, rat FGFR4
      QuantiFast Probe-based Assays in human, mouse, rat FGFR4

    Additional mRNA sequence: 

    AB209631.1 AF202063.1 AF359241.1 AF359246.1 AK225280.1 AK225909.1 AK301169.1 BC011847.2 
    EU826602.1 EU826603.1 L03840.1 M59373.1 X57205.1 

    11 DOTS entries:

    DT.95078845  DT.91981030  DT.100779841  DT.92434632  DT.100042493  DT.120858184  DT.92434636  DT.92434639 
    DT.92434634  DT.100033952  DT.86837266 

    Selected AceView cDNA sequences (see all 182):

    BM453707 AA424022 BQ690497 BE671952 AI989525 BF969971 BM874752 BE501873 
    BX280999 NM_022963 AF359246 NM_213647 AI926324 AW299662 BI115231 NM_002011 
    BM743990 BC011847 BM740261 CA394639 BE270306 BQ708634 BE205845 BQ899186 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FGFR4 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ·
    SP1:                                -     -                             -                                                                             -         
    SP2:                          -     -     -                             -                                                                             -         
    SP3:                                                                    -                                                                       -               
    SP4:                    -     -     -     -                             -                                                                                       
    SP5:                          -     -                                   -                                                                                       

    ExUns: 12d ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
    SP1:              -                                         -                     
    SP2:              -                                         -                     
    SP3:              -                                         -                     
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for FGFR4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FGFR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCCCTGG
    FGFR4 Expression
    About this image


    FGFR4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             Membranous Facial Bones
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H1 (WA01)
    FGFR4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGFR4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.165950

    UniProtKB/Swiss-Prot: FGFR4_HUMAN, P22455
    Tissue specificity: Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer
    cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGFR4: 
              Stem Cell Signaling in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FGFR4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGFR4
    QuantiTect SYBR Green Assays in human, mouse, rat FGFR4
    QuantiFast Probe-based Assays in human, mouse, rat FGFR4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGFR4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FGFR4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgfr41 , 5 fibroblast growth factor receptor 41, 5 85.51(n)1
    90.72(a)1
      13 (29.80 cM)5
    141861  NM_008011.21  NP_032037.21 
     551526405 
    chicken
    (Gallus gallus)
    Aves FGFR41 fibroblast growth factor receptor 4 74.47(n)
    72.81(a)
      395603  XM_003642072.2  XP_003642120.2 
    lizard
    (Anolis carolinensis)
    Reptilia FGFR46
    fibroblast growth factor receptor 4
    67(a)
    1 ↔ 1
    2(145246511-145275001)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977012 FGF receptor 4a 74.14(n)    D31761.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgfr41 fibroblast growth factor receptor 4 63.91(n)
    66.1(a)
      100000160  NM_131430.1  NP_571505.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tor3 eggshell pattern formation
    transmembrane receptor more
    52(a)
    (best of 3)
      43E12   --
    worm
    (Caenorhabditis elegans)
    Secernentea ver-23 protein kinase 39(a)
    (best of 16)
      III(146982-150196)   --


    ENSEMBL Gene Tree for FGFR4 (if available)
    TreeFam Gene Tree for FGFR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FGFR4 gene
    FLT42  PDGFRB2  CSF1R2  KIT2  FGFR32  PDGFRA2  RET2  KDR2  
    FGFR12  FGFR22  FLT32  FLT12  
    Selected SIMAP similar genes for FGFR4 using alignment to 9 protein entries:     FGFR4_HUMAN (see all proteins) (see all similar genes):
    FGFR-4    BEK    K-SAM    FGFR3    FGFR2    FGFR1
    CUX1    ABL1    RET/PTC2    CCDC6-RETa    CCDC6-RETc    MAPK8
    R12    urf-ret    DDR1    TXK    KIT    EPHA2

    FGFR4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FGFR4 (see all 525)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0461044
    A lung adenocarcinoma sample4--see VAR_0461042 P T mis40--------
    VAR_0461054
    A lung neuroendocrine carcinoma sample4--see VAR_0461052 S N mis40--------
    rs3518551,2,,4
    C,F,Hpathogenic1176744311(-) CAGCCC/TGGCCA 5 R G mis1 int1 ese324Minor allele frequency- G:0.00MN NA NS EA WA EU 5605
    rs796518131,2
    C--171445568(+) TCCTCC/TTCCTC 3 -- int12Minor allele frequency- T:0.33WA CSA 3
    rs456085361,2
    C,F--176514782(+) GACAGCAG/-TATCT 2 -- int15Minor allele frequency- -:0.04NS 162
    rs114293621,2
    C,F--176515591(+) GGTCAC/-CCGAT 2 -- int17Minor allele frequency- -:0.13NS NA CSA 150
    rs593900481,2
    C--176517136(+) TGTGTGTGT/-  
            
    CTTGG
    3 -- int11Minor allele frequency- -:0.00NA 2
    rs1507602131,2
    C--176524096(+) CCTCC-/TCCTCC
    TGCTCCTCT
    TCCTC
    3 -- int10--------
    rs1890473151,2
    --176524118(+) CTCCTC/GCTCCT 3 -- int10--------
    rs1882684581,2
    --176735963(+) CCTAAA/GCCTCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FGFR4 (176513887 - 176525145 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for FGFR4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657291CNV Deletion23128226
    nsv509101CNV Insertion20534489
    esv24424CNV Loss19812545
    nsv883157CNV Loss21882294
    nsv521574CNV Loss19592680
    nsv883156CNV Loss21882294
    dgv363n21CNV Gain19592680
    nsv482093CNV Gain20164927
    nsv823351CNV Gain20364138

    Human Gene Mutation Database (HGMD): FGFR4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGFR4
    DNA2.0 Custom Variant and Variant Library Synthesis for FGFR4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 134935    OMIM disorders: --

    Selected diseases for FGFR4 (see all 66):    
    About MalaCards
    cancer progression/metastasis    achondroplasia    syndromic diarrhea    breast fibroadenoma
    gliomatosis cerebri    anaplastic astrocytoma    alveolar rhabdomyosarcoma    craniosynostosis, syndromic
    craniosynostosis    sotos syndrome    pituitary tumors    irritable bowel syndrome
    constipation    chordoma    astrocytoma    cblc
    soft tissue sarcoma    pituitary adenoma    rhabdomyosarcoma    fatty liver disease

    1 disease from the University of Copenhagen DISEASES database for FGFR4:
    Craniosynostosis

    FGFR4 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FGFR4 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary tumors 48.7 9 12937159 (3), 12642581 (2), 16857743 (1), 11781352 (1) (see all 5)
    aggressiveness 41.7 4 15448004 (1), 19008009 (1)
    breast cancer 38.9 28 14710228 (3), 20066896 (2), 11549253 (2), 16012724 (2) (see all 15)
    cancer 34.1 33 19240166 (3), 17084840 (1), 17607666 (1), 19946327 (1) (see all 17)
    hnscc 32.6 5 18487077 (2), 15197773 (2)
    adenoma 31.6 9 15070963 (2)
    tumors 30.9 61 15070963 (3), 9740144 (3), 19008009 (3), 11958417 (2) (see all 32)
    pituitary adenoma 28.8 13 15070963 (4), 18070145 (2), 11781345 (1)
    adenocarcinoma lung 25.7 6 17487277 (3), 19296538 (1)
    astrocytoma 24.3 15 8679334 (5), 11958417 (2), 16198476 (1), 15981099 (1)

    Genetic Association Database (GAD): FGFR4
    Human Genome Epidemiology (HuGE) Navigator: FGFR4 (36 documents)
    Tumor Gene Database (TGDB): FGFR4

    Export disorders for FGFR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FGFR4 gene, integrated from 10 sources (see all 288):
    (articles sorted by number of sources associating them with FGFR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. (PubMed id 1709094)1, 2, 9 Partanen J.M.... Alitalo K. (EMBO J. 1991)
    2. Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention. (PubMed id 19008009)1, 4, 9 Ho H.K....Ullrich A. (J. Hepatol. 2009)
    3. Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer. (PubMed id 18949411)1, 4, 9 Sasaki H....Fujii Y. (Oncol. Rep. 2008)
    4. Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression. (PubMed id 18670643)1, 2, 9 Wang J.... Ittmann M.M. (Neoplasia 2008)
    5. Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis. (PubMed id 18762813)1, 4, 9 FitzGerald L.M....Ostrander E.A. (Prostate Cancer Prostatic Dis. 2009)
    6. Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population. (PubMed id 18756523)1, 4, 9 Ma Z....Habuchi T. (Int. J. Cancer 2008)
    7. Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study. (PubMed id 19500394)1, 4, 9 Nan H....Han J. (BMC Cancer 2009)
    8. FGFR4 Gly388Arg polymorphism may affect the clinical stage of patients with lung cancer by modulating the transcriptional profile of normal lung. (PubMed id 19296538)1, 4, 9 Falvella F.S....Dragani T.A. (Int. J. Cancer 2009)
    9. Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4. (PubMed id 17487277)1, 4, 9 Marks J.L....Pao W. (PLoS ONE 2007)
    10. FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer. (PubMed id 16822847)1, 4, 9 Thussbas C....Harbeck N. (J. Clin. Oncol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2264 HGNC: 3691 AceView: FGFR4 Ensembl:ENSG00000160867 euGenes: HUgn2264
    ECgene: FGFR4 Kegg: 2264 H-InvDB: FGFR4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FGFR4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGFR4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgfr4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FGFR4 gene:
    Search GeneIP for patents involving FGFR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     EMD Millipore Purified and/or Recombinant FGFR4 Protein
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for FGFR4 (FGF R4)   Browse Cell Culture Products  
     ELISAs for FGFR4 (FGF R4)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FGFR4 (FGF R4)   Browse Stem Cell Products  
     cDNA Clones for FGFR4 (FGF R4)   Proteome Profiler Antibody Arrays for FGFR4 (FGF R4)  
     OriGene Antibodies for FGFR4   OriGene RNAi products in human, mouse, rat for FGFR4  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FGFR4  
     OriGene MassSpec something-or-other for FGFR4   OriGene clones in human, mouse for FGFR4  
     OriGene qSTAR qPCR primer pairs in human, mouse for FGFR4   OriGene Purified Protein for FGFR4  
     OriGene ORF clones in mouse, rat for FGFR4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FGFR4   OriGene Custom Protein Services for FGFR4  

     
     
     Block miRNA regulation of human, mouse, rat FGFR4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FGFR4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGFR4 Predesigned siRNA for gene silencing in human, mouse, rat FGFR4
     QuantiFast Probe-based Assays in human, mouse, rat FGFR4 QuantiTect SYBR Green Assays in human, mouse, rat FGFR4
     PCR Arrays including human, mouse, rat FGFR4 Search Chromatin IP Primers for FGFR4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGFR4  GeneGlobe Interaction Network for FGFR4
     Regulatory tfbs in FGFR4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FGFR4 GenScript cDNA clones with any tag delivered in your preferred vector for FGFR4
     GenScript FGFR4-Activity-based Kinase Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for FGFR4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for FGFR4 

     Tocris compounds for FGFR4
     Proteins for FGFR4
     Cell Lysates for FGFR4
     cDNA Clones for FGFR4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FGFR4 antibodies
     FGFR4 proteins
     FGFR4 lysates
     Antibodies for FGFR4
     See all of Abcam's Antibodies, Kits and Proteins for FGFR4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FGFR4
     Proteins for FGFR4
     Antibodies for FGFR4
     ELISAs for FGFR4
     CLIAs for FGFR4



     Browse ESI BIO Cell Lines and PureStem Progenitors for FGFR4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGFR4
     SwitchGear 3'UTR luciferase reporter plasmids for FGFR4
     SwitchGear Promoter luciferase reporter plasmids for FGFR4
     ThermoFisher Antibodies for FGFR4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGFR4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGFR4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGFR4
     LSBio Antibodies in human, mouse, rat for FGFR4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for FGFR4
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FGFR4 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4