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Aliases for FGFR1OP2 Gene

Aliases for FGFR1OP2 Gene

  • FGFR1 Oncogene Partner 2 2 3 5
  • Fibroblast Growth Factor Receptor 1 Oncogene Partner 2 3
  • Wound Inducible Transcript 3.0 3
  • HSPC123-Like 3
  • WIT3.0 3

External Ids for FGFR1OP2 Gene

Previous GeneCards Identifiers for FGFR1OP2 Gene

  • GC00U912750
  • GC12P026983
  • GC12P026984
  • GC12P027091

Summaries for FGFR1OP2 Gene

GeneCards Summary for FGFR1OP2 Gene

FGFR1OP2 (FGFR1 Oncogene Partner 2) is a Protein Coding gene. Diseases associated with FGFR1OP2 include 8P11 Myeloproliferative Syndrome. Among its related pathways are VEGF Signaling Pathway and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is SIKE1.

UniProtKB/Swiss-Prot for FGFR1OP2 Gene

  • May be involved in wound healing pathway.

Additional gene information for FGFR1OP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFR1OP2 Gene

Genomics for FGFR1OP2 Gene

GeneHancer (GH) Regulatory Elements for FGFR1OP2 Gene

Promoters and enhancers for FGFR1OP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I026935 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 923 8.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B FGFR1OP2 INTS13 ENSG00000247903 TM7SF3 MED21 ITPR2 PIR61598
GH12I027330 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.3 +395.7 395713 7.4 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZNF48 GLIS2 ZNF416 ZNF207 ARNTL2 STK38L TM7SF3 MED21 HMGB1P49 FGFR1OP2 GC12P027317 ARNTL2-AS1
GH12I026473 Enhancer 1.2 FANTOM5 Ensembl ENCODE 1.8 -464.9 -464873 1 HDGF PKNOX1 BACH1 MAX BMI1 BATF IRF4 RELA POLR2A NFATC1 SSPN BHLHE41 FGFR1OP2 GC12P026450 GC12P026546 ITPR2
GH12I026471 Enhancer 1.3 FANTOM5 Ensembl ENCODE 1.6 -466.7 -466740 1.1 PKNOX1 SMAD1 BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 BHLHE41 SSPN FGFR1OP2 GC12P026450 GC12P026546 ITPR2
GH12I026952 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 +15.1 15058 1.1 RXRA GTF2E2 BHLHE40 CEBPB CEBPG ZBTB40 MITF ATF4 ZBTB33 NR2C2 ENSG00000247903 ITPR2 FGFR1OP2 PIR61598
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FGFR1OP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FGFR1OP2 gene promoter:

Genomic Locations for FGFR1OP2 Gene

Genomic Locations for FGFR1OP2 Gene
chr12:26,938,372-26,966,650
(GRCh38/hg38)
Size:
28,279 bases
Orientation:
Plus strand
chr12:27,091,305-27,119,583
(GRCh37/hg19)

Genomic View for FGFR1OP2 Gene

Genes around FGFR1OP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFR1OP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFR1OP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFR1OP2 Gene

Proteins for FGFR1OP2 Gene

  • Protein details for FGFR1OP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVK5-FGOP2_HUMAN
    Recommended name:
    FGFR1 oncogene partner 2
    Protein Accession:
    Q9NVK5
    Secondary Accessions:
    • Q6R955
    • Q8N5L7
    • Q9P034
    • Q9UFK8

    Protein attributes for FGFR1OP2 Gene

    Size:
    253 amino acids
    Molecular mass:
    29426 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF29087.1; Type=Frameshift; Positions=61, 67, 72, 91; Evidence={ECO:0000305}; Sequence=CAB56012.1; Type=Frameshift; Positions=189; Evidence={ECO:0000305};

    Alternative splice isoforms for FGFR1OP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGFR1OP2 Gene

Post-translational modifications for FGFR1OP2 Gene

  • Ubiquitination at Lys188 and posLast=212212

Other Protein References for FGFR1OP2 Gene

No data available for DME Specific Peptides for FGFR1OP2 Gene

Domains & Families for FGFR1OP2 Gene

Gene Families for FGFR1OP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for FGFR1OP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FGFR1OP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVK5

UniProtKB/Swiss-Prot:

FGOP2_HUMAN :
  • Belongs to the SIKE family.
Family:
  • Belongs to the SIKE family.
genes like me logo Genes that share domains with FGFR1OP2: view

Function for FGFR1OP2 Gene

Molecular function for FGFR1OP2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in wound healing pathway.

Gene Ontology (GO) - Molecular Function for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with FGFR1OP2: view

Phenotypes for FGFR1OP2 Gene

genes like me logo Genes that share phenotypes with FGFR1OP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FGFR1OP2 Gene

Localization for FGFR1OP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFR1OP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFR1OP2 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FGFR1OP2: view

Pathways & Interactions for FGFR1OP2 Gene

genes like me logo Genes that share pathways with FGFR1OP2: view

Pathways by source for FGFR1OP2 Gene

Gene Ontology (GO) - Biological Process for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009611 response to wounding IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0042060 wound healing IEA --
genes like me logo Genes that share ontologies with FGFR1OP2: view

No data available for SIGNOR curated interactions for FGFR1OP2 Gene

Drugs & Compounds for FGFR1OP2 Gene

No Compound Related Data Available

Transcripts for FGFR1OP2 Gene

Unigene Clusters for FGFR1OP2 Gene

FGFR1 oncogene partner 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFR1OP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for FGFR1OP2 Gene

GeneLoc Exon Structure for
FGFR1OP2
ECgene alternative splicing isoforms for
FGFR1OP2

Expression for FGFR1OP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGFR1OP2 Gene

Protein differential expression in normal tissues from HIPED for FGFR1OP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.8), CD8 Tcells (7.8), and Platelet (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FGFR1OP2 Gene



Protein tissue co-expression partners for FGFR1OP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGFR1OP2 Gene:

FGFR1OP2

SOURCE GeneReport for Unigene cluster for FGFR1OP2 Gene:

Hs.591162

mRNA Expression by UniProt/SwissProt for FGFR1OP2 Gene:

Q9NVK5-FGOP2_HUMAN
Tissue specificity: Expressed in bone marrow, spleen and thymus.

Evidence on tissue expression from TISSUES for FGFR1OP2 Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Blood(4.1)
  • Bone marrow(2.4)
genes like me logo Genes that share expression patterns with FGFR1OP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFR1OP2 Gene

Orthologs for FGFR1OP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGFR1OP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGFR1OP2 34 33
  • 99.87 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 98 (a)
OneToMany
-- 34
  • 92 (a)
OneToMany
-- 34
  • 90 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FGFR1OP2 34 33
  • 93.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FGFR1OP2 34 33
  • 93.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fgfr1op2 16 34 33
  • 89.06 (n)
rat
(Rattus norvegicus)
Mammalia Fgfr1op2 33
  • 88.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FGFR1OP2 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGFR1OP2 34 33
  • 82.02 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGFR1OP2 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfr1op2 33
  • 71.01 (n)
Str.19970 33
African clawed frog
(Xenopus laevis)
Amphibia MGC52963 33
zebrafish
(Danio rerio)
Actinopterygii fgfr1op2 34 33
  • 71.01 (n)
OneToOne
wufj17h04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2577 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012118 33
  • 50.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10158 33 34
  • 47.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8091 34
  • 39 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7504 33
Species where no ortholog for FGFR1OP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGFR1OP2 Gene

ENSEMBL:
Gene Tree for FGFR1OP2 (if available)
TreeFam:
Gene Tree for FGFR1OP2 (if available)

Paralogs for FGFR1OP2 Gene

Paralogs for FGFR1OP2 Gene

(1) SIMAP similar genes for FGFR1OP2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FGFR1OP2 Gene

genes like me logo Genes that share paralogs with FGFR1OP2: view

Variants for FGFR1OP2 Gene

Sequence variations from dbSNP and Humsavar for FGFR1OP2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000159073 -- 26,950,336(+) C/A intron_variant
rs1000167621 -- 26,943,192(+) T/C intron_variant
rs1000199733 -- 26,943,463(+) A/G intron_variant
rs1000307069 -- 26,956,747(+) T/C intron_variant
rs1000371226 -- 26,944,987(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FGFR1OP2 Gene

Variant ID Type Subtype PubMed ID
esv3892164 CNV loss 25118596
esv3892165 CNV loss 25118596
nsv557804 CNV loss 21841781

Variation tolerance for FGFR1OP2 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGFR1OP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGFR1OP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFR1OP2 Gene

Disorders for FGFR1OP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FGFR1OP2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
8p11 myeloproliferative syndrome
  • 8p11 stem cell leukemia/lymphoma syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

FGOP2_HUMAN
  • Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.

Additional Disease Information for FGFR1OP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FGFR1OP2: view

No data available for Genatlas for FGFR1OP2 Gene

Publications for FGFR1OP2 Gene

  1. Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. (PMID: 15034873) Grand EK … Cross NC (Genes, chromosomes & cancer 2004) 2 3 4 22 58
  2. Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. (PMID: 16946300) Gu TL … Polakiewicz RD (Blood 2006) 3 4 22 58
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58

Products for FGFR1OP2 Gene

Sources for FGFR1OP2 Gene

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