Aliases for FGFR1OP2 Gene
Aliases for FGFR1OP2 Gene
External Ids for FGFR1OP2 Gene
- HGNC: 23098
- Entrez Gene: 26127
- Ensembl: ENSG00000111790
- OMIM: 608858
- UniProtKB: Q9NVK5
Previous GeneCards Identifiers for FGFR1OP2 Gene
- GC00U912750
- GC12P026983
- GC12P026984
- GC12P027091
Summaries for FGFR1OP2 Gene
GeneCards Summary for FGFR1OP2 Gene
FGFR1OP2 (FGFR1 Oncogene Partner 2) is a Protein Coding gene. Diseases associated with FGFR1OP2 include 8P11 Myeloproliferative Syndrome. Among its related pathways are FGFR1 mutant receptor activation and HIV Life Cycle. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is SIKE1.
UniProtKB/Swiss-Prot for FGFR1OP2 Gene
-
May be involved in wound healing pathway.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFR1OP2 Gene
Genomics for FGFR1OP2 Gene
Regulatory Elements for FGFR1OP2 Gene
- Transcription factor binding sites by QIAGEN in the FGFR1OP2 gene promoter:
Regulatory Element Products
Genomic Location for FGFR1OP2 Gene
- Chromosome:
- 12
- Start:
- 26,938,372 bp from pter
- End:
- 26,966,650 bp from pter
- Size:
- 28,279 bases
- Orientation:
- Plus strand
Genomic View for FGFR1OP2 Gene
- Cytogenetic band:
-
- 12p11.23 by Ensembl
- 12p11.23 by Entrez Gene
- 12p11.23 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGFR1OP2 Gene
Proteins for FGFR1OP2 Gene
-
Protein details for FGFR1OP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NVK5-FGOP2_HUMAN
- Recommended name:
- FGFR1 oncogene partner 2
- Protein Accession:
- Q9NVK5
- Q6R955
- Q8N5L7
- Q9P034
- Q9UFK8
Protein attributes for FGFR1OP2 Gene
- Size:
- 253 amino acids
- Molecular mass:
- 29426 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAF29087.1; Type=Frameshift; Positions=61, 67, 72, 91; Evidence={ECO:0000305}; Sequence=CAB56012.1; Type=Frameshift; Positions=189; Evidence={ECO:0000305};
Protein Expression for FGFR1OP2 Gene
Post-translational modifications for FGFR1OP2 Gene
Other Protein References for FGFR1OP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FGFR1OP2
- Invitrogen Antibodies for FGFR1OP2
- antibodies-online Antibodies for FGFR1OP2: See all 47
- GeneTex FGFR1OP2 antibody for FGFR1OP2
Protein Products
-
OriGene Purified Proteins for FGFR1OP2
- Search Origene for MassSpec and Protein Over-expression Lysates for FGFR1OP2
- Origene Custom Protein Services for FGFR1OP2
- antibodies-online Proteins for FGFR1OP2: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FGFR1OP2
Assay Products
- antibodies-online Kits for FGFR1OP2: See all 4
No data available for DME Specific Peptides for FGFR1OP2 Gene
Domains & Families for FGFR1OP2 Gene
Gene Families for FGFR1OP2 Gene
- HGNC:
Suggested Antigen Peptide Sequences for FGFR1OP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NVK5- Family:
-
- Belongs to the SIKE family.
Function for FGFR1OP2 Gene
Molecular function for FGFR1OP2 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in wound healing pathway.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0042803 | protein homodimerization activity | IEA | -- |
Phenotypes for FGFR1OP2 Gene
- GenomeRNAi human phenotypes for FGFR1OP2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FGFR1OP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFR1OP2 gene
- Search ViGene Biosciences for FGFR1OP2
CRISPR Products
-
OriGene CRISPR knockouts for FGFR1OP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGFR1OP2
- GenScript: Design CRISPR guide RNA sequences for FGFR1OP2
miRNA for FGFR1OP2 Gene
- miRTarBase miRNAs that target FGFR1OP2
-
- hsa-mir-361-5p (MIRT020087)
- hsa-mir-6848-3p (MIRT633267)
- hsa-mir-6843-3p (MIRT633268)
- hsa-mir-3187-3p (MIRT633269)
- hsa-mir-588 (MIRT633270)
- hsa-mir-4701-5p (MIRT633271)
- hsa-mir-548s (MIRT633272)
- hsa-mir-519e-5p (MIRT633273)
- hsa-mir-515-5p (MIRT633274)
- hsa-mir-1200 (MIRT633275)
- hsa-mir-378a-5p (MIRT633276)
- hsa-mir-6131 (MIRT633277)
- hsa-mir-3663-5p (MIRT633278)
- hsa-mir-5695 (MIRT633279)
- hsa-mir-519d-5p (MIRT633280)
- hsa-mir-4716-5p (MIRT633281)
- hsa-mir-4781-3p (MIRT633282)
- hsa-mir-3156-3p (MIRT642699)
- hsa-mir-4284 (MIRT642700)
- hsa-mir-4772-3p (MIRT642701)
- hsa-mir-4638-5p (MIRT642702)
- hsa-mir-532-3p (MIRT642703)
- hsa-mir-1304-3p (MIRT642704)
- hsa-mir-6741-3p (MIRT642705)
- hsa-mir-4726-3p (MIRT642706)
- hsa-mir-6764-5p (MIRT642707)
- hsa-mir-1915-3p (MIRT642708)
- hsa-mir-6840-3p (MIRT642709)
- hsa-mir-4301 (MIRT642710)
- hsa-mir-6890-3p (MIRT642711)
- hsa-mir-711 (MIRT712707)
- hsa-mir-6859-3p (MIRT712708)
- hsa-mir-6756-3p (MIRT712709)
- hsa-mir-3127-3p (MIRT712710)
miRNA Products
- Search ViGene Biosciences for FGFR1OP2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FGFR1OP2
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-
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for FGFR1OP2
-
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-
ViGene Biosciences lentiviral particle packaged cDNA for FGFR1OP2 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FGFR1OP2 Gene
Localization for FGFR1OP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGFR1OP2 Gene
- Cytoplasm.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for FGFR1OP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FGFR1 mutant receptor activation | ||
| 2 | HIV Life Cycle |
.45
|
|
| 3 | VEGF Signaling Pathway | ||
| 4 | Signaling by FGFR2 in disease | ||
Pathways by source for FGFR1OP2 Gene
6 Reactome pathways for FGFR1OP2 Gene
1 PharmGKB pathway for FGFR1OP2 Gene
Interacting Proteins for FGFR1OP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009611 | response to wounding | IEA | -- |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | -- |
| GO:0042060 | wound healing | IEA | -- |
No data available for SIGNOR curated interactions for FGFR1OP2 Gene
Transcripts for FGFR1OP2 Gene
mRNA/cDNA for FGFR1OP2 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (200) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGFR1OP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FGFR1OP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGFR1OP2
- GenScript: Design CRISPR guide RNA sequences for FGFR1OP2
miRNA Products
- Search ViGene Biosciences for FGFR1OP2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FGFR1OP2
- Browse OriGene Inhibitory RNA Products For FGFR1OP2
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFR1OP2 gene
Clone Products
- Sino Biological Human cDNA Clone for FGFR1OP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: |
Expression for FGFR1OP2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FGFR1OP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGFR1OP2 Gene:
FGFR1OP2SOURCE GeneReport for Unigene cluster for FGFR1OP2 Gene:
Hs.591162mRNA Expression by UniProt/SwissProt for FGFR1OP2 Gene:
Q9NVK5-FGOP2_HUMANEvidence on tissue expression from TISSUES for FGFR1OP2 Gene
- Nervous system(4.7)
- Liver(4.2)
- Blood(4.1)
- Bone marrow(2.4)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for FGFR1OP2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFR1OP2 Gene
Orthologs for FGFR1OP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGFR1OP2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | FGFR1OP2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FGFR1OP2 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fgfr1op2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fgfr1op2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FGFR1OP2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGFR1OP2 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FGFR1OP2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgfr1op2 34 |
|
||
| Str.19970 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC52963 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgfr1op2 34 35 |
|
||
| wufj17h04 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2577 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012118 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10158 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8091 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.7504 34 |
|
- Species where no ortholog for FGFR1OP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGFR1OP2 Gene
(1) SIMAP similar genes for FGFR1OP2 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for FGFR1OP2 Gene
Variants for FGFR1OP2 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000159073 | -- | 26,950,336(+) | TCCTG(A/C)CTCAG | intron-variant | |
| rs1000167621 | -- | 26,943,192(+) | TTTGT(C/T)GAAAA | intron-variant | |
| rs1000199733 | -- | 26,943,463(+) | TGTCA(A/G)TTTCT | intron-variant | |
| rs1000307069 | -- | 26,956,747(+) | ACATA(C/T)GAACA | intron-variant | |
| rs1000371226 | -- | 26,944,987(+) | ATCCA(A/G)TTCAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3892164 | CNV | loss | 25118596 |
| esv3892165 | CNV | loss | 25118596 |
| nsv557804 | CNV | loss | 21841781 |
Relevant External Links for FGFR1OP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FGFR1OP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFR1OP2 Gene
Disorders for FGFR1OP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| 8p11 myeloproliferative syndrome |
|
|
UniProtKB/Swiss-Prot
FGOP2_HUMAN- Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
Relevant External Links for FGFR1OP2
No data available for Genatlas for FGFR1OP2 Gene
Publications for FGFR1OP2 Gene
- Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. (PMID: 15034873) Grand E.K. … Cross N.C.P. (Genes Chromosomes Cancer 2004) 2 3 4 22 64
- Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. (PMID: 16946300) Gu T.-L. … Polakiewicz R.D. (Blood 2006) 3 4 22 64
- A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
Products for FGFR1OP2 Gene
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- Novus Biologicals Antibodies for FGFR1OP2
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- antibodies-online Antibodies for FGFR1OP2: See all 47
- antibodies-online Kits for FGFR1OP2: See all 4
- antibodies-online Proteins for FGFR1OP2: See all 11
- Search antibodies-online for peptides
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- ViGene Biosciences adenoviral particle packaged cDNA for FGFR1OP2 gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FGFR1OP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
- (116) SCBT
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (138) UDN
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer



