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Aliases for FGFR1OP2 Gene

Aliases for FGFR1OP2 Gene

  • FGFR1 Oncogene Partner 2 2 3 5
  • Fibroblast Growth Factor Receptor 1 Oncogene Partner 2 3
  • Wound Inducible Transcript 3.0 3
  • HSPC123-Like 3
  • WIT3.0 3

External Ids for FGFR1OP2 Gene

Previous GeneCards Identifiers for FGFR1OP2 Gene

  • GC00U912750
  • GC12P026983
  • GC12P026984
  • GC12P027091

Summaries for FGFR1OP2 Gene

GeneCards Summary for FGFR1OP2 Gene

FGFR1OP2 (FGFR1 Oncogene Partner 2) is a Protein Coding gene. Diseases associated with FGFR1OP2 include 8P11 Myeloproliferative Syndrome. Among its related pathways are FGFR1 mutant receptor activation and Infectious disease. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is SIKE1.

UniProtKB/Swiss-Prot for FGFR1OP2 Gene

  • May be involved in wound healing pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFR1OP2 Gene

Genomics for FGFR1OP2 Gene

Regulatory Elements for FGFR1OP2 Gene

Enhancers for FGFR1OP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FGFR1OP2 on UCSC Golden Path with GeneCards custom track

Promoters for FGFR1OP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FGFR1OP2 Gene

26,938,372 bp from pter
26,966,650 bp from pter
28,279 bases
Plus strand

Genomic View for FGFR1OP2 Gene

Genes around FGFR1OP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFR1OP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFR1OP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFR1OP2 Gene

Proteins for FGFR1OP2 Gene

  • Protein details for FGFR1OP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FGFR1 oncogene partner 2
    Protein Accession:
    Secondary Accessions:
    • Q6R955
    • Q8N5L7
    • Q9P034
    • Q9UFK8

    Protein attributes for FGFR1OP2 Gene

    253 amino acids
    Molecular mass:
    29426 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF29087.1; Type=Frameshift; Positions=61, 67, 72, 91; Evidence={ECO:0000305}; Sequence=CAB56012.1; Type=Frameshift; Positions=189; Evidence={ECO:0000305};

    Alternative splice isoforms for FGFR1OP2 Gene


neXtProt entry for FGFR1OP2 Gene

Post-translational modifications for FGFR1OP2 Gene

  • Ubiquitination at Lys 188 and Lys 212
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFR1OP2 Gene

No data available for DME Specific Peptides for FGFR1OP2 Gene

Domains & Families for FGFR1OP2 Gene

Protein Domains for FGFR1OP2 Gene


Suggested Antigen Peptide Sequences for FGFR1OP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SIKE family.
  • Belongs to the SIKE family.
genes like me logo Genes that share domains with FGFR1OP2: view

No data available for Gene Families for FGFR1OP2 Gene

Function for FGFR1OP2 Gene

Molecular function for FGFR1OP2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in wound healing pathway.

Gene Ontology (GO) - Molecular Function for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with FGFR1OP2: view

Phenotypes for FGFR1OP2 Gene

genes like me logo Genes that share phenotypes with FGFR1OP2: view

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FGFR1OP2 Gene

Localization for FGFR1OP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFR1OP2 Gene


Subcellular locations from

Jensen Localization Image for FGFR1OP2 Gene COMPARTMENTS Subcellular localization image for FGFR1OP2 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FGFR1OP2: view

Pathways & Interactions for FGFR1OP2 Gene

genes like me logo Genes that share pathways with FGFR1OP2: view

Pathways by source for FGFR1OP2 Gene

Gene Ontology (GO) - Biological Process for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009611 response to wounding IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0042060 wound healing IEA --
genes like me logo Genes that share ontologies with FGFR1OP2: view

No data available for SIGNOR curated interactions for FGFR1OP2 Gene

Drugs & Compounds for FGFR1OP2 Gene

No Compound Related Data Available

Transcripts for FGFR1OP2 Gene

Unigene Clusters for FGFR1OP2 Gene

FGFR1 oncogene partner 2:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFR1OP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: -

Relevant External Links for FGFR1OP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGFR1OP2 Gene

mRNA expression in normal human tissues for FGFR1OP2 Gene

Protein differential expression in normal tissues from HIPED for FGFR1OP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.8), CD8 Tcells (7.8), and Platelet (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FGFR1OP2 Gene

Protein tissue co-expression partners for FGFR1OP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGFR1OP2 Gene:


SOURCE GeneReport for Unigene cluster for FGFR1OP2 Gene:


mRNA Expression by UniProt/SwissProt for FGFR1OP2 Gene:

Tissue specificity: Expressed in bone marrow, spleen and thymus.
genes like me logo Genes that share expression patterns with FGFR1OP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FGFR1OP2 Gene

Orthologs for FGFR1OP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGFR1OP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FGFR1OP2 34
  • 93.96 (n)
  • 98.83 (a)
  • 97 (a)
(Canis familiaris)
Mammalia FGFR1OP2 34
  • 93.33 (n)
  • 98.6 (a)
  • 98 (a)
(Mus musculus)
Mammalia Fgfr1op2 34
  • 89.06 (n)
  • 98.81 (a)
Fgfr1op2 16
Fgfr1op2 35
  • 99 (a)
(Pan troglodytes)
Mammalia FGFR1OP2 34
  • 99.87 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Fgfr1op2 34
  • 88.67 (n)
  • 97.63 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 90 (a)
-- 35
  • 78 (a)
-- 35
  • 98 (a)
-- 35
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia FGFR1OP2 35
  • 77 (a)
(Gallus gallus)
Aves FGFR1OP2 34
  • 82.02 (n)
  • 93.95 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia FGFR1OP2 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfr1op2 34
  • 71.01 (n)
  • 84.19 (a)
Str.19970 34
African clawed frog
(Xenopus laevis)
Amphibia MGC52963 34
(Danio rerio)
Actinopterygii fgfr1op2 34
  • 71.01 (n)
  • 76.74 (a)
wufj17h04 34
fgfr1op2 35
  • 76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2577 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012118 34
  • 50.79 (n)
  • 46.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10158 34
  • 47.41 (n)
  • 35 (a)
CG10158 35
  • 20 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7504 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8091 35
  • 39 (a)
Species where no ortholog for FGFR1OP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGFR1OP2 Gene

Gene Tree for FGFR1OP2 (if available)
Gene Tree for FGFR1OP2 (if available)

Paralogs for FGFR1OP2 Gene

Paralogs for FGFR1OP2 Gene

(1) SIMAP similar genes for FGFR1OP2 Gene using alignment to 2 proteins: Pseudogenes for FGFR1OP2 Gene

genes like me logo Genes that share paralogs with FGFR1OP2: view

Variants for FGFR1OP2 Gene

Sequence variations from dbSNP and Humsavar for FGFR1OP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1872192 -- 26,952,777(+) TTCTG(G/T)GGCAA intron-variant
rs2046937 -- 26,956,722(+) TATTT(A/G)TTGCT intron-variant
rs2129091 -- 26,966,684(-) GAATA(A/C)GGGTA downstream-variant-500B
rs2129092 -- 26,954,335(+) AAGCA(A/G)TCATT intron-variant
rs7954107 -- 26,942,778(+) gtctt(G/T)tattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGFR1OP2 Gene

Variant ID Type Subtype PubMed ID
esv3892164 CNV loss 25118596
esv3892165 CNV loss 25118596
nsv557804 CNV loss 21841781

Variation tolerance for FGFR1OP2 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGFR1OP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFR1OP2 Gene

Disorders for FGFR1OP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FGFR1OP2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
8p11 myeloproliferative syndrome
  • 8p11 stem cell leukemia/lymphoma syndrome
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.

Relevant External Links for FGFR1OP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FGFR1OP2: view

No data available for Genatlas for FGFR1OP2 Gene

Publications for FGFR1OP2 Gene

  1. Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. (PMID: 15034873) Grand E.K. … Cross N.C.P. (Genes Chromosomes Cancer 2004) 2 3 4 22 65
  2. Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. (PMID: 16946300) Gu T.-L. … Polakiewicz R.D. (Blood 2006) 3 4 22 65
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 65

Products for FGFR1OP2 Gene

Sources for FGFR1OP2 Gene

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