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Aliases for FGFR1OP2 Gene

Aliases for FGFR1OP2 Gene

  • FGFR1 Oncogene Partner 2 2 3
  • Fibroblast Growth Factor Receptor 1 Oncogene Partner 2 3
  • Wound Inducible Transcript 3.0 3
  • HSPC123-Like 3
  • WIT3.0 3

External Ids for FGFR1OP2 Gene

Previous GeneCards Identifiers for FGFR1OP2 Gene

  • GC00U912750
  • GC12P026983
  • GC12P026984
  • GC12P027091

Summaries for FGFR1OP2 Gene

GeneCards Summary for FGFR1OP2 Gene

FGFR1OP2 (FGFR1 Oncogene Partner 2) is a Protein Coding gene. Diseases associated with FGFR1OP2 include 8p11 myeloproliferative syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR1 mutants. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is SIKE1.

UniProtKB/Swiss-Prot for FGFR1OP2 Gene

  • May be involved in wound healing pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFR1OP2 Gene

Genomics for FGFR1OP2 Gene

Regulatory Elements for FGFR1OP2 Gene

Genomic Location for FGFR1OP2 Gene

26,938,372 bp from pter
26,966,650 bp from pter
28,279 bases
Plus strand

Genomic View for FGFR1OP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGFR1OP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFR1OP2 Gene

Proteins for FGFR1OP2 Gene

  • Protein details for FGFR1OP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FGFR1 oncogene partner 2
    Protein Accession:
    Secondary Accessions:
    • Q6R955
    • Q8N5L7
    • Q9P034
    • Q9UFK8

    Protein attributes for FGFR1OP2 Gene

    253 amino acids
    Molecular mass:
    29426 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF29087.1; Type=Frameshift; Positions=61, 67, 72, 91; Evidence={ECO:0000305}; Sequence=CAB56012.1; Type=Frameshift; Positions=189; Evidence={ECO:0000305};

    Alternative splice isoforms for FGFR1OP2 Gene


neXtProt entry for FGFR1OP2 Gene

Proteomics data for FGFR1OP2 Gene at MOPED

Post-translational modifications for FGFR1OP2 Gene

  • Ubiquitination at Lys188 and Lys212
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFR1OP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGFR1OP2 Gene

Domains for FGFR1OP2 Gene

Protein Domains for FGFR1OP2 Gene


Suggested Antigen Peptide Sequences for FGFR1OP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SIKE family.
  • Belongs to the SIKE family.
genes like me logo Genes that share domains with FGFR1OP2: view

No data available for Gene Families for FGFR1OP2 Gene

Function for FGFR1OP2 Gene

Molecular function for FGFR1OP2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in wound healing pathway.

Gene Ontology (GO) - Molecular Function for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with FGFR1OP2: view

Phenotypes for FGFR1OP2 Gene

GenomeRNAi human phenotypes for FGFR1OP2:
genes like me logo Genes that share phenotypes with FGFR1OP2: view

Animal Model Products

CRISPR Products

miRNA for FGFR1OP2 Gene

miRTarBase miRNAs that target FGFR1OP2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGFR1OP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FGFR1OP2 Gene

Localization for FGFR1OP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFR1OP2 Gene


Subcellular locations from

Jensen Localization Image for FGFR1OP2 Gene COMPARTMENTS Subcellular localization image for FGFR1OP2 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FGFR1OP2: view

Pathways for FGFR1OP2 Gene

genes like me logo Genes that share pathways with FGFR1OP2: view

Pathways by source for FGFR1OP2 Gene

Gene Ontology (GO) - Biological Process for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009611 response to wounding --
GO:0042060 wound healing IEA --
genes like me logo Genes that share ontologies with FGFR1OP2: view

Transcripts for FGFR1OP2 Gene

Unigene Clusters for FGFR1OP2 Gene

FGFR1 oncogene partner 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGFR1OP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFR1OP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: -

Relevant External Links for FGFR1OP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGFR1OP2 Gene

mRNA expression in normal human tissues for FGFR1OP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FGFR1OP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.8), CD8 Tcells (7.8), and Platelet (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FGFR1OP2 Gene

SOURCE GeneReport for Unigene cluster for FGFR1OP2 Gene Hs.591162

mRNA Expression by UniProt/SwissProt for FGFR1OP2 Gene

Tissue specificity: Expressed in bone marrow, spleen and thymus
genes like me logo Genes that share expressions with FGFR1OP2: view

Expression partners for FGFR1OP2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FGFR1OP2 Gene

Orthologs for FGFR1OP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGFR1OP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FGFR1OP2 35
  • 93.96 (n)
  • 98.83 (a)
  • 97 (a)
(Canis familiaris)
Mammalia FGFR1OP2 35
  • 93.33 (n)
  • 98.6 (a)
  • 98 (a)
(Mus musculus)
Mammalia Fgfr1op2 35
  • 89.06 (n)
  • 98.81 (a)
Fgfr1op2 16
Fgfr1op2 36
  • 99 (a)
(Pan troglodytes)
Mammalia FGFR1OP2 35
  • 99.87 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Fgfr1op2 35
  • 88.67 (n)
  • 97.63 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
-- 36
  • 78 (a)
-- 36
  • 98 (a)
-- 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia FGFR1OP2 36
  • 77 (a)
(Gallus gallus)
Aves FGFR1OP2 35
  • 82.02 (n)
  • 93.95 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia FGFR1OP2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfr1op2 35
  • 71.01 (n)
  • 84.19 (a)
Str.19970 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52963 35
(Danio rerio)
Actinopterygii fgfr1op2 35
  • 71.01 (n)
  • 76.74 (a)
wufj17h04 35
fgfr1op2 36
  • 76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2577 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012118 35
  • 50.79 (n)
  • 46.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10158 35
  • 47.41 (n)
  • 35 (a)
CG10158 36
  • 20 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7504 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8091 36
  • 39 (a)
Species with no ortholog for FGFR1OP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGFR1OP2 Gene

Gene Tree for FGFR1OP2 (if available)
Gene Tree for FGFR1OP2 (if available)

Paralogs for FGFR1OP2 Gene

Paralogs for FGFR1OP2 Gene

(1) SIMAP similar genes for FGFR1OP2 Gene using alignment to 2 proteins: Pseudogenes for FGFR1OP2 Gene

genes like me logo Genes that share paralogs with FGFR1OP2: view

Variants for FGFR1OP2 Gene

Sequence variations from dbSNP and Humsavar for FGFR1OP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs708162 -- 26,943,574(+) aatcc(A/C)agcac intron-variant
rs840895 -- 26,957,090(-) AGCTG(C/T)GGGAA intron-variant
rs859024 -- 26,949,924(+) TGATT(A/G)TGTCA intron-variant
rs1051513 -- 26,963,014(+) ATTCC(C/T)GTTAC intron-variant
rs1058701 -- 26,960,580(+) CTTGA(A/C)GCACC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FGFR1OP2 Gene

Variant ID Type Subtype PubMed ID
nsv898935 CNV Loss 21882294
dgv1397n71 CNV Loss 21882294
nsv898938 CNV Loss 21882294

Relevant External Links for FGFR1OP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFR1OP2 Gene

Disorders for FGFR1OP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FGFR1OP2 Gene in MalaCards »

(1) Disease for FGFR1OP2 Gene


  • Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.

Relevant External Links for FGFR1OP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FGFR1OP2: view

No data available for OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FGFR1OP2 Gene

Publications for FGFR1OP2 Gene

  1. Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. (PMID: 15034873) Grand E.K. … Cross N.C.P. (Genes Chromosomes Cancer 2004) 2 3 4 23
  2. Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. (PMID: 16946300) Gu T.-L. … Polakiewicz R.D. (Blood 2006) 3 4 23
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 48

Products for FGFR1OP2 Gene

Sources for FGFR1OP2 Gene

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