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FGFR1OP2 Gene

protein-coding   GIFtS: 56
GCID: GC12P027091

FGFR1 Oncogene Partner 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FGFR1 Oncogene Partner 21 2
HSPC123-like2
WIT3.02
Fibroblast Growth Factor Receptor 1 Oncogene Partner 22
Wound Inducible Transcript 3.02

External Ids:    HGNC: 230981   Entrez Gene: 261272   Ensembl: ENSG000001117907   OMIM: 6088585   UniProtKB: Q9NVK53   

Export aliases for FGFR1OP2 gene to outside databases

Previous GC identifers: GC00U912750 GC12P026983 GC12P026984 GC12P026861


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FGFR1OP2 Gene:
FGFR1OP2 (FGFR1 oncogene partner 2) is a protein-coding gene. Diseases associated with FGFR1OP2 include 8p11 myeloproliferative syndrome, and cerebral cavernous malformations 3. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is SIKE1.

UniProtKB/Swiss-Prot: FGOP2_HUMAN, Q9NVK5
Function: May be involved in wound healing pathway (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGFR1OP2 gene promoter:
         Elk-1   AML1a   Nkx2-2   HSF1 (long)   HNF-3beta   GATA-2   Egr-4   FAC1   HFH-1   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FGFR1OP2 promoter sequence
   Search Chromatin IP Primers for FGFR1OP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGFR1OP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.23   Ensembl cytogenetic band:  12p11.23   HGNC cytogenetic band: 12p12.1

FGFR1OP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGFR1OP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P027091:  view genomic region     (about GC identifiers)

Start:
27,091,305 bp from pter      End:
27,119,583 bp from pter
Size:
28,279 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FGOP2_HUMAN, Q9NVK5 (See protein sequence)
Recommended Name: FGFR1 oncogene partner 2  
Size: 253 amino acids; 29426 Da
Sequence caution: Sequence=AAF29087.1; Type=Frameshift; Positions=61, 67, 72, 91; Sequence=CAB56012.1;
Type=Frameshift; Positions=189;
Secondary accessions: Q6R955 Q8N5L7 Q9P034 Q9UFK8
Alternative splicing: 3 isoforms:  Q9NVK5-1   Q9NVK5-2   Q9NVK5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FGFR1OP2: NX_Q9NVK5

Explore proteomics data for FGFR1OP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys188, Lys212
  • Modification sites at PhosphoSitePlus

  • See FGFR1OP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001165358.1  NP_001165359.1  NP_056448.1  

    ENSEMBL proteins: 
     ENSP00000229395   ENSP00000441144   ENSP00000437556   ENSP00000323763  
    Reactome Protein details: Q9NVK5

    FGFR1OP2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008555 SIKE

    Graphical View of Domain Structure for InterPro Entry Q9NVK5

    ProtoNet protein and cluster: Q9NVK5

    UniProtKB/Swiss-Prot: FGOP2_HUMAN, Q9NVK5
    Similarity: Belongs to the SIKE family


    FGFR1OP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGOP2_HUMAN, Q9NVK5
    Function: May be involved in wound healing pathway (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042803protein homodimerization activity IEA--
         
    FGFR1OP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FGFR1OP2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGFR1OP2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGFR1OP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGFR1OP2

    miRNA
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    miRTarBase miRNAs that target FGFR1OP2:
    hsa-mir-361-5p (MIRT020087)

    Block miRNA regulation of human, mouse, rat FGFR1OP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGFR1OP2 (see all 23):
    hsa-miR-495 hsa-miR-520d-5p hsa-miR-1297 hsa-miR-1244 hsa-miR-7-1* hsa-miR-558 hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidFGFR1OP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FGFR1OP2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGFR1OP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGOP2_HUMAN, Q9NVK5: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    FGFR1OP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGFR1OP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR1 mutants
    Signaling by FGFR1 mutants0.67
    Signaling by FGFR1 fusion mutants0.00
    Signaling by FGFR mutants0.67
    2Signaling by FGFR
    Signaling by FGFR in disease0.91
    3VEGF Signaling Pathway
    VEGF Signaling Pathway0.34
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for FGFR1OP2
        Signaling by FGFR1 fusion mutants

    1 PharmGKB Pathway for FGFR1OP2
        VEGF Signaling Pathway


    FGFR1OP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FGFR1OP2
    Interactions:

        Search GeneGlobe Interaction Network for FGFR1OP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGFR1OP2 (Q9NVK53 ENSP000002293954) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK24Q9Y6E03, ENSP000003657304I2D: score=2 STRING: ENSP00000365730
    TRAF3IP3Q9Y2283, ENSP000000103384I2D: score=2 STRING: ENSP00000010338
    ZRANB1Q9UGI03, ENSP000003526764I2D: score=2 STRING: ENSP00000352676
    PPP2R1AP301533, ENSP000003248044I2D: score=1 STRING: ENSP00000324804
    STRNO438153, ENSP000002639184I2D: score=1 STRING: ENSP00000263918
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009611response to wounding ----
    GO:0042060wound healing IEA--

    FGFR1OP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGFR1OP2 (FGOP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FGFR1OP2 gene (3 alternative transcripts): 
    NM_001171887.1  NM_001171888.1  NM_015633.2  

    Unigene Cluster for FGFR1OP2:

    FGFR1 oncogene partner 2
    Hs.591162  [show with all ESTs]
    Unigene Representative Sequence: NM_015633
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229395(uc001rhm.3 uc001rhn.3) ENST00000544111 ENST00000395941
    ENST00000546072(uc001rhl.3) ENST00000327214 ENST00000538172
    miRNA
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    Block miRNA regulation of human, mouse, rat FGFR1OP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGFR1OP2 (see all 23):
    hsa-miR-495 hsa-miR-520d-5p hsa-miR-1297 hsa-miR-1244 hsa-miR-7-1* hsa-miR-558 hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidFGFR1OP2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): FGFR1OP2 (NM_015633)
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      QuantiTect SYBR Green Assays in human, mouse, rat FGFR1OP2
      QuantiFast Probe-based Assays in human, mouse, rat FGFR1OP2

    Additional mRNA sequence: 

    AF086411.1 AF161472.1 AK001534.1 AK094888.1 AL117545.1 AL117608.1 AY506561.1 BC032143.2 

    9 DOTS entries:

    DT.100646168  DT.210166  DT.100042064  DT.100751357  DT.442919  DT.95200942  DT.40118670  DT.95087970 
    DT.95088329 

    Selected AceView cDNA sequences (see all 200):

    BQ694324 BI829470 AA262972 BU787452 BE894371 CB158376 BX395292 AA730013 
    BX954938 Z99418 AL699273 CD678165 BM782815 AA384443 BU739995 AW571785 
    BQ435164 BX507394 BM972617 BM768371 CB104864 BC032143 AK001534 W74643 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FGFR1OP2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                      -           -     -                           
    SP2:              -                       -     -     -     -                           
    SP3:              -                       -           -     -                           
    SP4:              -                       -                                             
    SP5:              -                                                                     


    ECgene alternative splicing isoforms for FGFR1OP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGFR1OP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAAAGACA
    FGFR1OP2 Expression
    About this image


    FGFR1OP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    FGFR1OP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGFR1OP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591162

    UniProtKB/Swiss-Prot: FGOP2_HUMAN, Q9NVK5
    Tissue specificity: Expressed in bone marrow, spleen and thymus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGFR1OP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FGFR1OP2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgfr1op21 , 5 FGFR1 oncogene partner 21, 5 89.06(n)1
    98.81(a)1
      6 (77.70 cM)5
    675291  NM_026218.21  NP_080494.11 
     1465772035 
    chicken
    (Gallus gallus)
    Aves FGFR1OP21 FGFR1 oncogene partner 2 82.02(n)
    93.95(a)
      418214  NM_001007855.1  NP_001007856.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGFR1OP26
    FGFR1 oncogene partner 2
    81(a)
    1 ↔ 1
    5(91093306-91099956)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC529632 hypothetical protein MGC52963 74(n)    BC041504.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj17h042 wufj17h04 76.31(n)   335511  BC053266.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101581 CG10158 47.41(n)
    35(a)
      33971  NM_135240.4  NP_609084.1 


    ENSEMBL Gene Tree for FGFR1OP2 (if available)
    TreeFam Gene Tree for FGFR1OP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGFR1OP2 gene
    SIKE12  
    1 SIMAP similar gene for FGFR1OP2 using alignment to 2 protein entries:     FGOP2_HUMAN (see all proteins):
    SIKE1

    FGFR1OP2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for FGFR1OP2
    PGOHUM00000239609 PGOHUM00000239768 PGOHUM00000248548


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGFR1OP2 (see all 542)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730846211,2
    C,F--27093421(+) TGCGTT/ACTTTC 3 -- int11Minor allele frequency- A:0.01WA 118
    rs1482050701,2
    --27093536(+) GACACA/GTACCT 3 -- int10--------
    rs8408691,2
    C,F,O,A,H--27093585(+) AGACAC/GATCTG 3 -- int129Minor allele frequency- G:0.16MN NA NS EA WA CSA 2174
    rs749783721,2
    F--27093625(+) GTAGAT/AGTAGT 3 -- int11Minor allele frequency- A:0.02EA 120
    rs1418500931,2
    --27093632(+) TAGTGG/TTAGGA 3 -- int10--------
    rs1996846901,2
    --27093765(+) TGAAA-/TTTTTT 3 -- int10--------
    rs1904061261,2
    --27093861(+) AATTTG/TTCTTA 3 -- int10--------
    rs1462816221,2
    C--27094135(+) GCACTA/GTAAAA 3 -- int10--------
    rs118304591,2
    H--27094390(+) CACTGT/CGTTTC 3 -- int14Minor allele frequency- C:0.00NS EA 420
    rs1380098641,2
    --27094487(+) TTTAAA/GTGTAG 3 -- int10--------

    HapMap Linkage Disequilibrium report for FGFR1OP2 (27091305 - 27119583 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FGFR1OP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898935CNV Loss21882294
    nsv898938CNV Loss21882294
    dgv1397n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608858    OMIM disorders: --

    UniProtKB/Swiss-Prot: FGOP2_HUMAN, Q9NVK5
  • Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder
    (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and
    T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein
    FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity

  • 14 diseases for FGFR1OP2:    
    About MalaCards
    8p11 myeloproliferative syndrome    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation
    lymphoblastic lymphoma    eosinophilia    cerebritis    t-cell leukemia
    acute myeloid leukemia    myeloid leukemia    leukemia    malaria
    multiple myeloma    myeloma


    FGFR1OP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FGFR1OP2
    Human Genome Epidemiology (HuGE) Navigator: FGFR1OP2 (2 documents)

    Export disorders for FGFR1OP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGFR1OP2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with FGFR1OP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. (PubMed id 15034873)1, 2, 3, 9 Grand E.K.... Cross N.C.P. (Genes Chromosomes Cancer 2004)
    2. Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. (PubMed id 16946300)1, 2, 9 Gu T.-L....Polakiewicz R.D. (Blood 2006)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (Oncogene 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26127 HGNC: 23098 AceView: FGFR1OP2 Ensembl:ENSG00000111790 euGenes: HUgn26127
    ECgene: FGFR1OP2 H-InvDB: FGFR1OP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGFR1OP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGFR1OP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGFR1OP2 gene:
    Search GeneIP for patents involving FGFR1OP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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