Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FGFR1OP Gene

Aliases for FGFR1OP Gene

  • FGFR1 Oncogene Partner 2 3 5
  • FOP 3 4
  • Fibroblast Growth Factor Receptor 1 Oncogene Partner 3

External Ids for FGFR1OP Gene

Previous GeneCards Identifiers for FGFR1OP Gene

  • GC06P167246
  • GC06P167322
  • GC06P167384
  • GC06P167332
  • GC06P167412
  • GC06P164887

Summaries for FGFR1OP Gene

Entrez Gene Summary for FGFR1OP Gene

  • This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]

GeneCards Summary for FGFR1OP Gene

FGFR1OP (FGFR1 Oncogene Partner) is a Protein Coding gene. Diseases associated with FGFR1OP include Graves' Disease and Crohn's Disease. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and HIV Life Cycle. GO annotations related to this gene include protein homodimerization activity and protein kinase binding.

UniProtKB/Swiss-Prot for FGFR1OP Gene

  • Required for anchoring microtubules to the centrosomes.

Gene Wiki entry for FGFR1OP Gene

Additional gene information for FGFR1OP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFR1OP Gene

Genomics for FGFR1OP Gene

Regulatory Elements for FGFR1OP Gene

Enhancers for FGFR1OP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H166004 1.6 FANTOM5 Ensembl ENCODE 21.2 -992.1 -992110 4.8 PKNOX1 SIN3A FEZF1 BRCA1 ZNF2 ZNF121 GLIS2 FOS ZNF202 TSHZ1 FGFR1OP HNRNPA1P49 T PRR18 LINC00473 LOC105378117
GH06H167150 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +153.4 153358 3.4 PKNOX1 TBL1XR1 SIN3A BATF ATF7 ETV6 RUNX3 CREM IKZF2 CBFB GPR31 RNASET2 CCR6 LOC105378120 FGFR1OP ENSG00000249141 UNC93A RPS6KA2 RPS6KA2-AS1 AFDN
GH06H167089 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +93.8 93789 7.3 HDGF PKNOX1 TBL1XR1 SIN3A BMI1 BATF ZNF143 ZNF207 ATF7 ETV6 RNASET2 LOC105378120 FGFR1OP CCR6 GPR31 PIR47545 PIR53334
GH06H167046 1.4 FANTOM5 Ensembl ENCODE 12 +48.3 48264 2.2 HDGF CTCF PKNOX1 TBL1XR1 MAX BATF RAD21 POLR2A ZNF366 EED RNASET2 CCR6 FGFR1OP LOC105378120 ENSG00000249141 GPR31 GC06P167051 PIR56971 GC06P167042
GH06H166624 1.5 FANTOM5 ENCODE dbSUPER 9.8 -372.3 -372328 4.9 HDGF PKNOX1 ATF1 ARNT ZNF2 GLIS2 ZNF207 FOS SP3 NFYC FGFR1OP RPS6KA2 GC06M166644 FAM103A2P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGFR1OP on UCSC Golden Path with GeneCards custom track

Promoters for FGFR1OP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000206900 -82 2601 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 SP3

Genomic Locations for FGFR1OP Gene

Genomic Locations for FGFR1OP Gene
53,532 bases
Plus strand

Genomic View for FGFR1OP Gene

Genes around FGFR1OP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFR1OP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFR1OP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFR1OP Gene

Proteins for FGFR1OP Gene

  • Protein details for FGFR1OP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FGFR1 oncogene partner
    Protein Accession:
    Secondary Accessions:
    • A8K1D1
    • B2R705
    • Q49AI0
    • Q5R3F6
    • Q96EW1

    Protein attributes for FGFR1OP Gene

    399 amino acids
    Molecular mass:
    43065 Da
    Quaternary structure:
    • Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1.

    Three dimensional structures from OCA and Proteopedia for FGFR1OP Gene

    Alternative splice isoforms for FGFR1OP Gene


neXtProt entry for FGFR1OP Gene

Post-translational modifications for FGFR1OP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGFR1OP Gene

No data available for DME Specific Peptides for FGFR1OP Gene

Domains & Families for FGFR1OP Gene

Gene Families for FGFR1OP Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for FGFR1OP Gene

Suggested Antigen Peptide Sequences for FGFR1OP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FGFR1OP family.
  • Belongs to the FGFR1OP family.
genes like me logo Genes that share domains with FGFR1OP: view

Function for FGFR1OP Gene

Molecular function for FGFR1OP Gene

UniProtKB/Swiss-Prot Function:
Required for anchoring microtubules to the centrosomes.

Phenotypes From GWAS Catalog for FGFR1OP Gene

Gene Ontology (GO) - Molecular Function for FGFR1OP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005515 protein binding IPI 17888034
GO:0019901 protein kinase binding IPI 17888034
GO:0030292 protein tyrosine kinase inhibitor activity IDA 17888034
GO:0042803 protein homodimerization activity IDA 16690081
genes like me logo Genes that share ontologies with FGFR1OP: view
genes like me logo Genes that share phenotypes with FGFR1OP: view

Animal Models for FGFR1OP Gene

MGI Knock Outs for FGFR1OP:

Animal Model Products

CRISPR Products

miRNA for FGFR1OP Gene

miRTarBase miRNAs that target FGFR1OP

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGFR1OP Gene

Localization for FGFR1OP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFR1OP Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with gamma-tubulin.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFR1OP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FGFR1OP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17888034
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 16690081
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with FGFR1OP: view

Pathways & Interactions for FGFR1OP Gene

genes like me logo Genes that share pathways with FGFR1OP: view

Pathways by source for FGFR1OP Gene

SIGNOR curated interactions for FGFR1OP Gene


Gene Ontology (GO) - Biological Process for FGFR1OP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006469 negative regulation of protein kinase activity IDA 17888034
GO:0008284 positive regulation of cell proliferation IDA 17888034
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with FGFR1OP: view

Drugs & Compounds for FGFR1OP Gene

No Compound Related Data Available

Transcripts for FGFR1OP Gene

Unigene Clusters for FGFR1OP Gene

FGFR1 oncogene partner:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFR1OP Gene

No ASD Table

Relevant External Links for FGFR1OP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGFR1OP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGFR1OP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FGFR1OP Gene

This gene is overexpressed in Testis (45.0) and Blymphocyte (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FGFR1OP Gene

Protein tissue co-expression partners for FGFR1OP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FGFR1OP Gene:


SOURCE GeneReport for Unigene cluster for FGFR1OP Gene:


mRNA Expression by UniProt/SwissProt for FGFR1OP Gene:

Tissue specificity: Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.

Evidence on tissue expression from TISSUES for FGFR1OP Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Blood(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with FGFR1OP: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFR1OP Gene

Orthologs for FGFR1OP Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGFR1OP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FGFR1OP 33 34
  • 99.25 (n)
(Bos Taurus)
Mammalia FGFR1OP 33 34
  • 87.47 (n)
(Rattus norvegicus)
Mammalia LOC683722 33
  • 87.47 (n)
(Canis familiaris)
Mammalia FGFR1OP 33 34
  • 86.5 (n)
(Mus musculus)
Mammalia Fgfr1op 33 16 34
  • 86.38 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
-- 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia FGFR1OP 34
  • 73 (a)
(Gallus gallus)
Aves FGFR1OP 33 34
  • 72.84 (n)
(Anolis carolinensis)
Reptilia FGFR1OP 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfr1op 33
  • 64.58 (n)
Str.6447 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15774 33
(Danio rerio)
Actinopterygii fgfr1op 33 34
  • 60.23 (n)
Dr.3646 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.846 33
Species where no ortholog for FGFR1OP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGFR1OP Gene

Gene Tree for FGFR1OP (if available)
Gene Tree for FGFR1OP (if available)

Paralogs for FGFR1OP Gene

No data available for Paralogs for FGFR1OP Gene

Variants for FGFR1OP Gene

Sequence variations from dbSNP and Humsavar for FGFR1OP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000032773 -- 167,037,680(+) AGAGG(A/G)TATGT intron-variant
rs1000046212 -- 166,999,493(+) AACAG(A/C)GGGGT upstream-variant-2KB, reference, missense
rs1000111003 -- 167,010,766(+) TATTT(A/G)TGTTT intron-variant
rs1000210776 -- 167,028,500(+) GTTTT(A/G)CAACA intron-variant
rs1000221327 -- 167,020,714(+) GACCA(A/G)CGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGFR1OP Gene

Variant ID Type Subtype PubMed ID
nsv605260 CNV gain 21841781
nsv519550 CNV loss 19592680
nsv464140 CNV loss 19166990
nsv1124147 CNV deletion 24896259
esv3355616 CNV duplication 20981092
esv3327167 CNV insertion 20981092
esv2752099 CNV gain 17911159
esv2733216 CNV deletion 23290073
esv2733215 CNV deletion 23290073
esv2733214 CNV deletion 23290073
esv2733213 CNV deletion 23290073
esv2182370 CNV deletion 18987734

Variation tolerance for FGFR1OP Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.83; 73.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGFR1OP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFR1OP Gene

Disorders for FGFR1OP Gene

MalaCards: The human disease database

(4) MalaCards diseases for FGFR1OP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
graves' disease
  • toxic diffuse goiter
crohn's disease
  • crohn disease
bone marrow cancer
  • bone marrow neoplasm
8p11 myeloproliferative syndrome
  • 8p11 stem cell leukemia/lymphoma syndrome
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity (PubMed:9949182). {ECO:0000269 PubMed:9949182}.

Relevant External Links for FGFR1OP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FGFR1OP: view

No data available for Genatlas for FGFR1OP Gene

Publications for FGFR1OP Gene

  1. The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. (PMID: 9949182) Popovici C … Pébusque MJ (Blood 1999) 2 3 4 22 60
  2. A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. (PMID: 16314388) Yan X … Nigg EA (Molecular biology of the cell 2006) 3 4 22 60
  3. Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. (PMID: 16690081) Mikolajka A … Holak TA (Journal of molecular biology 2006) 3 4 22 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. (PMID: 20526339) Quan C … Zhang XJ (Nature genetics 2010) 3 45 60

Products for FGFR1OP Gene

Sources for FGFR1OP Gene

Loading form....