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Aliases for FGFR1OP Gene

Aliases for FGFR1OP Gene

  • FGFR1 Oncogene Partner 2 3
  • FOP 3 4 6
  • Fibroblast Growth Factor Receptor 1 Oncogene Partner 3

External Ids for FGFR1OP Gene

Previous GeneCards Identifiers for FGFR1OP Gene

  • GC06P167246
  • GC06P167322
  • GC06P167384
  • GC06P167332
  • GC06P167412
  • GC06P164887

Summaries for FGFR1OP Gene

Entrez Gene Summary for FGFR1OP Gene

  • This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]

GeneCards Summary for FGFR1OP Gene

FGFR1OP (FGFR1 Oncogene Partner) is a Protein Coding gene. Diseases associated with FGFR1OP include steroid-induced glaucoma and 8p11 myeloproliferative syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR1 mutants. GO annotations related to this gene include protein homodimerization activity and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for FGFR1OP Gene

  • Required for anchoring microtubules to the centrosomes.

Gene Wiki entry for FGFR1OP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFR1OP Gene

Genomics for FGFR1OP Gene

Regulatory Elements for FGFR1OP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FGFR1OP Gene

Start:
166,999,182 bp from pter
End:
167,052,713 bp from pter
Size:
53,532 bases
Orientation:
Plus strand

Genomic View for FGFR1OP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGFR1OP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFR1OP Gene

Proteins for FGFR1OP Gene

  • Protein details for FGFR1OP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95684-FR1OP_HUMAN
    Recommended name:
    FGFR1 oncogene partner
    Protein Accession:
    O95684
    Secondary Accessions:
    • A8K1D1
    • B2R705
    • Q49AI0
    • Q5R3F6
    • Q96EW1

    Protein attributes for FGFR1OP Gene

    Size:
    399 amino acids
    Molecular mass:
    43065 Da
    Quaternary structure:
    • Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1.

    Three dimensional structures from OCA and Proteopedia for FGFR1OP Gene

    Alternative splice isoforms for FGFR1OP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGFR1OP Gene

Proteomics data for FGFR1OP Gene at MOPED

Post-translational modifications for FGFR1OP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGFR1OP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGFR1OP Gene

Domains for FGFR1OP Gene

Protein Domains for FGFR1OP Gene

Suggested Antigen Peptide Sequences for FGFR1OP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95684

UniProtKB/Swiss-Prot:

FR1OP_HUMAN :
  • O95684
Domain:
  • Contains 1 LisH domain.
Family:
  • Belongs to the FGFR1OP family.
genes like me logo Genes that share domains with FGFR1OP: view

No data available for Gene Families for FGFR1OP Gene

Function for FGFR1OP Gene

Molecular function for FGFR1OP Gene

UniProtKB/Swiss-Prot Function:
Required for anchoring microtubules to the centrosomes.

Gene Ontology (GO) - Molecular Function for FGFR1OP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005515 protein binding IPI 17888034
GO:0019901 protein kinase binding IPI 17888034
GO:0030292 protein tyrosine kinase inhibitor activity IDA 17888034
GO:0042803 protein homodimerization activity IDA 16690081
genes like me logo Genes that share ontologies with FGFR1OP: view

Animal Model Products

CRISPR Products

miRNA for FGFR1OP Gene

miRTarBase miRNAs that target FGFR1OP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGFR1OP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FGFR1OP Gene

Localization for FGFR1OP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFR1OP Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with gamma-tubulin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGFR1OP Gene COMPARTMENTS Subcellular localization image for FGFR1OP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for FGFR1OP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17888034
GO:0005813 centrosome IDA 16690081
GO:0005815 microtubule organizing center --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IDA 17888034
genes like me logo Genes that share ontologies with FGFR1OP: view

Pathways for FGFR1OP Gene

genes like me logo Genes that share pathways with FGFR1OP: view

Pathways by source for FGFR1OP Gene

Gene Ontology (GO) - Biological Process for FGFR1OP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006469 negative regulation of protein kinase activity IDA 17888034
GO:0006996 organelle organization TAS --
GO:0008284 positive regulation of cell proliferation IDA 17888034
genes like me logo Genes that share ontologies with FGFR1OP: view

Transcripts for FGFR1OP Gene

Unigene Clusters for FGFR1OP Gene

FGFR1 oncogene partner:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGFR1OP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFR1OP Gene

No ASD Table

Relevant External Links for FGFR1OP Gene

GeneLoc Exon Structure for
FGFR1OP
ECgene alternative splicing isoforms for
FGFR1OP

Expression for FGFR1OP Gene

mRNA expression in normal human tissues for FGFR1OP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FGFR1OP Gene

This gene is overexpressed in Testis (45.0) and Blymphocyte (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FGFR1OP Gene

SOURCE GeneReport for Unigene cluster for FGFR1OP Gene Hs.487175

mRNA Expression by UniProt/SwissProt for FGFR1OP Gene

O95684-FR1OP_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.
genes like me logo Genes that share expressions with FGFR1OP: view

Expression partners for FGFR1OP Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FGFR1OP Gene

Orthologs for FGFR1OP Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGFR1OP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGFR1OP 35
  • 87.47 (n)
  • 88.97 (a)
FGFR1OP 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGFR1OP 35
  • 86.5 (n)
  • 88.55 (a)
FGFR1OP 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgfr1op 35
  • 86.38 (n)
  • 84.71 (a)
Fgfr1op 16
Fgfr1op 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGFR1OP 35
  • 99.25 (n)
  • 98.99 (a)
FGFR1OP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC683722 35
  • 87.47 (n)
  • 86.97 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FGFR1OP 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGFR1OP 35
  • 72.84 (n)
  • 69.89 (a)
FGFR1OP 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGFR1OP 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfr1op 35
  • 64.58 (n)
  • 59.4 (a)
Str.6447 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15774 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3646 35
fgfr1op 35
  • 60.23 (n)
  • 61.05 (a)
fgfr1op 36
  • 37 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.846 35
Species with no ortholog for FGFR1OP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGFR1OP Gene

ENSEMBL:
Gene Tree for FGFR1OP (if available)
TreeFam:
Gene Tree for FGFR1OP (if available)

Paralogs for FGFR1OP Gene

No data available for Paralogs for FGFR1OP Gene

Variants for FGFR1OP Gene

Sequence variations from dbSNP and Humsavar for FGFR1OP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs151604 -- 167,039,757(-) atgtc(A/G)gtgaa intron-variant
rs151605 -- 167,032,078(-) TTTCT(G/T)GGCCA intron-variant
rs151606 -- 167,016,994(-) AAAAA(A/T)AAATA intron-variant
rs162283 -- 167,005,692(+) ttgtg(C/T)gctta intron-variant
rs162284 -- 167,014,357(-) TAGTA(C/T)GCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGFR1OP Gene

Variant ID Type Subtype PubMed ID
esv2733213 CNV Deletion 23290073
esv2182370 CNV Deletion 18987734
esv2733214 CNV Deletion 23290073
esv2733215 CNV Deletion 23290073
esv2733216 CNV Deletion 23290073
nsv464140 CNV Loss 19166990
nsv886943 CNV Loss 21882294
esv2752099 CNV Gain 17911159
nsv519550 CNV Loss 19592680

Relevant External Links for FGFR1OP Gene

HapMap Linkage Disequilibrium report
FGFR1OP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFR1OP Gene

Disorders for FGFR1OP Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FGFR1OP Gene in MalaCards »

(3) Diseases for FGFR1OP Gene including...

UniProtKB/Swiss-Prot

FR1OP_HUMAN
  • Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.

(1) University of Copenhagen DISEASES for FGFR1OP Gene

(1) Novoseek inferred disease relationships for FGFR1OP Gene

Disease -log(P) Hits PubMed IDs
myeloproliferative disorders 69.1 1

Relevant External Links for FGFR1OP

Genetic Association Database (GAD)
FGFR1OP
Human Genome Epidemiology (HuGE) Navigator
FGFR1OP
genes like me logo Genes that share disorders with FGFR1OP: view

No data available for OMIM and Genatlas for FGFR1OP Gene

Publications for FGFR1OP Gene

  1. The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. (PMID: 9949182) Popovici C. … Pebusque M.-J. (Blood 1999) 2 3 4 23
  2. A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. (PMID: 16314388) Yan X. … Nigg E.A. (Mol. Biol. Cell 2006) 3 4 23
  3. Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. (PMID: 16690081) Mikolajka A. … Holak T.A. (J. Mol. Biol. 2006) 3 4 23
  4. Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. (PMID: 17888034) Mano Y. … Daigo Y. (Cancer Sci. 2007) 3 23
  5. [The 8p11 myeloproliferative syndrome]. (PMID: 10373756) Reither A. … Cross N.C. (Med. Klin. (Munich) 1999) 2 3

Products for FGFR1OP Gene

Sources for FGFR1OP Gene

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