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FGFR1OP Gene

protein-coding   GIFtS: 60
GCID: GC06P167412

FGFR1 Oncogene Partner

  See FGFR1OP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FGFR1 Oncogene Partner1 2
FOP2 3 5
Fibroblast Growth Factor Receptor 1 Oncogene Partner2

External Ids:    HGNC: 170121   Entrez Gene: 111162   Ensembl: ENSG000002130667   OMIM: 6053925   UniProtKB: O956843   

Export aliases for FGFR1OP gene to outside databases

Previous GC identifers: GC06P167246 GC06P167322 GC06P167384 GC06P167332 GC06P164887


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGFR1OP Gene:
This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to
subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth
factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric
protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of
FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo.
Alternatively spliced transcript variants that encode different proteins have been identified. (provided by
RefSeq, Jul 2013)

GeneCards Summary for FGFR1OP Gene:
FGFR1OP (FGFR1 oncogene partner) is a protein-coding gene. Diseases associated with FGFR1OP include myeloproliferative disorder, and steroid-induced glaucoma. GO annotations related to this gene include protein tyrosine kinase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: FR1OP_HUMAN, O95684
Function: Required for anchoring microtubules to the centrosomes

Gene Wiki entry for FGFR1OP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGFR1OP gene promoter:
         FOXF2   Sp1   Pax-5   CUTL1   POU3F2   MEF-2A   HOXA5   c-Myb   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FGFR1OP promoter sequence
   Search Chromatin IP Primers for FGFR1OP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGFR1OP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

FGFR1OP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGFR1OP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P167412:  view genomic region     (about GC identifiers)

Start:
167,412,670 bp from pter      End:
167,466,201 bp from pter
Size:
53,532 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FR1OP_HUMAN, O95684 (See protein sequence)
Recommended Name: FGFR1 oncogene partner  
Size: 399 amino acids; 43065 Da
Subunit: Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with
CEP350 and MAPRE1
1 PDB 3D structure from and Proteopedia for FGFR1OP:
2D68 (3D)    
Secondary accessions: A8K1D1 B2R705 Q49AI0 Q5R3F6 Q96EW1
Alternative splicing: 3 isoforms:  O95684-1   O95684-2   O95684-3   

Explore the universe of human proteins at neXtProt for FGFR1OP: NX_O95684

Explore proteomics data for FGFR1OP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGFR1OP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265619.1  NP_008976.1  NP_919410.1  

    ENSEMBL proteins: 
     ENSP00000355812   ENSP00000230248  
    Reactome Protein details: O95684

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006594 LisH_dimerisation
     IPR018993 FOP_dimerisation-dom_N

    Graphical View of Domain Structure for InterPro Entry O95684

    ProtoNet protein and cluster: O95684

    1 Blocks protein domain: IPB006594 Lissencephaly type-1-like homology motif

    UniProtKB/Swiss-Prot: FR1OP_HUMAN, O95684
    Similarity: Belongs to the FGFR1OP family
    Similarity: Contains 1 LisH domain


    Find genes that share domains with FGFR1OP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FR1OP_HUMAN, O95684
    Function: Required for anchoring microtubules to the centrosomes

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0005515protein binding IPI17888034
    GO:0019901protein kinase binding IPI17888034
    GO:0030292protein tyrosine kinase inhibitor activity IDA17888034
    GO:0042803protein homodimerization activity IDA16690081
         
    Find genes that share ontologies with FGFR1OP           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Fgfr1op (no phenotypes)

    Find genes that share phenotypes with FGFR1OP           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGFR1OP
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    miRTarBase miRNAs that target FGFR1OP:
    hsa-mir-192-5p (MIRT026178)

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    7 qRT-PCR Assays for microRNAs that regulate FGFR1OP:
    hsa-miR-495 hsa-miR-1184 hsa-miR-124 hsa-miR-1252 hsa-miR-506 hsa-miR-219-5p hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidFGFR1OP 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for FGFR1OP
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FR1OP_HUMAN, O95684: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with
    gamma-tubulin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17888034
    GO:0005813centrosome IDA16690081
    GO:0005815microtubule organizing center ----
    GO:0005829cytosol TAS--
    GO:0048471perinuclear region of cytoplasm IDA17888034

    Find genes that share ontologies with FGFR1OP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGFR1OP About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    2Signaling by FGFR1 mutants
    Signaling by FGFR1 mutants0.67
    Signaling by FGFR1 fusion mutants0.00
    Signaling by FGFR mutants0.67
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Signaling by FGFR
    Signaling by FGFR in disease0.91
    5VEGF Signaling Pathway
    VEGF Signaling Pathway0.34


    Find genes that share SuperPaths with FGFR1OP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5 Reactome Pathways for FGFR1OP
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Signaling by FGFR1 fusion mutants
    Regulation of PLK1 Activity at G2/M Transition
    Loss of Nlp from mitotic centrosomes

    1 PharmGKB Pathway for FGFR1OP
        VEGF Signaling Pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FGFR1OP
    Interactions:

        Search GeneGlobe Interaction Network for FGFR1OP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGFR1OP (O956842, 3 ENSP000003558124) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAGKQ9UJ702, 3, ENSP000002442044MINT-8263467 I2D: score=2 STRING: ENSP00000244204
    PPP2CBP627143, ENSP000002211384I2D: score=2 STRING: ENSP00000221138
    PPP2R1BP301543, ENSP000003113444I2D: score=2 STRING: ENSP00000311344
    CEP350Q5VT063, ENSP000003565794I2D: score=1 STRING: ENSP00000356579
    PPP2R1AP301533, ENSP000003248044I2D: score=1 STRING: ENSP00000324804
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006469negative regulation of protein kinase activity IDA17888034
    GO:0008284positive regulation of cell proliferation IDA17888034
    GO:0018108peptidyl-tyrosine phosphorylation TAS--

    Find genes that share ontologies with FGFR1OP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGFR1OP (FR1OP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGFR1OP gene (3 alternative transcripts): 
    NM_001278690.1  NM_007045.3  NM_194429.2  

    Unigene Cluster for FGFR1OP:

    FGFR1 oncogene partner
    Hs.487175  [show with all ESTs]
    Unigene Representative Sequence: BC037785
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366847(uc011egp.1 uc003qvj.3 uc003qvk.3) ENST00000349556
    ENST00000494781 ENST00000476078 ENST00000496181 ENST00000488525
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate FGFR1OP:
    hsa-miR-495 hsa-miR-1184 hsa-miR-124 hsa-miR-1252 hsa-miR-506 hsa-miR-219-5p hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidFGFR1OP 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat FGFR1OP
      QuantiFast Probe-based Assays in human, mouse, rat FGFR1OP

    Additional mRNA sequence: 

    AJ420472.1 AK289846.1 AK294950.1 AK312791.1 BC011902.2 BC037785.1 Y18046.1 

    13 DOTS entries:

    DT.440730  DT.100758392  DT.100651743  DT.95359744  DT.121386135  DT.95290749  DT.101963467  DT.121386076 
    DT.121386109  DT.121386137  DT.97804512  DT.99965900  DT.99983130 

    Selected AceView cDNA sequences (see all 78):

    AA720658 AA292126 BG289619 BM874378 NM_004367 NM_031409 BU193028 BC037960 
    AI566733 AY242126 BE550052 CB306621 AL043487 BQ082444 AW160364 AA865712 
    BF942057 AI872081 AW575605 BM999497 BX279700 BG400623 AW404691 AW627471 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGFR1OP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAAAGGTG
    FGFR1OP Expression
    About this image


    FGFR1OP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
    FGFR1OP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGFR1OP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487175

    UniProtKB/Swiss-Prot: FR1OP_HUMAN, O95684
    Tissue specificity: Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland,
    prostate, testis, and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGFR1OP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGFR1OP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgfr1op1 , 5 Fgfr1 oncogene partner1, 5 86.38(n)1
    84.71(a)1
      17 (4.88 cM)5
    752961  NM_001197046.11  NP_001183975.11 
     81655015 
    chicken
    (Gallus gallus)
    Aves FGFR1OP1 FGFR1 oncogene partner 72.84(n)
    69.89(a)
      421568  XM_419609.4  XP_419609.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGFR1OP6
    FGFR1 oncogene partner
    66(a)
    1 ↔ 1
    1(225512476-225546348)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.157742 Xenopus laevis transcribed sequence with moderate similarity more 77.62(n)    BX854166.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.36462 Transcribed sequence with weak similarity to protein more 74.1(n)    CK352943.1 


    ENSEMBL Gene Tree for FGFR1OP (if available)
    TreeFam Gene Tree for FGFR1OP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGFR1OP (see all 1038)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800322041,2
    C--167411298(+) AGAGAC/TGTGTT 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs778400421,2
    C--167411300(+) AGATGC/TGTTTG 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs756929431,2
    C--167411301(+) GATGTG/ATTTGG 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs132160141,2
    C--167411314(+) GCCAGC/TGTGGA 2 -- us2k10--------
    rs1132942561,2
    C--167411343(+) TACACAT/-GTGAC 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs770725201,2
    C--167411362(+) TGCACA/GCCCAC 2 -- us2k10--------
    rs730242341,2
    C--167411388(+) GAGGCC/GTTTGG 2 -- us2k10--------
    rs1896820551,2
    --167413426(+) CGTTTC/TTGACC 2 -- int10--------
    rs755293941,2
    C,F--167413451(+) CCCAGC/TTCGTT 2 -- int11Minor allele frequency- T:0.14WA 118
    rs781274931,2
    C,F--167413482(+) TGGATA/CAATGT 2 -- int11Minor allele frequency- C:0.15WA 118

    HapMap Linkage Disequilibrium report for FGFR1OP (167412670 - 167466201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for FGFR1OP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733216CNV Deletion23290073
    esv2733215CNV Deletion23290073
    esv2733213CNV Deletion23290073
    esv2733214CNV Deletion23290073
    esv2182370CNV Deletion18987734
    nsv886943CNV Loss21882294
    nsv464140CNV Loss19166990
    nsv519550CNV Loss19592680
    esv2752099CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605392    OMIM disorders: --

    UniProtKB/Swiss-Prot: FR1OP_HUMAN, O95684
  • Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder
    (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and
    T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins
    FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming
    activity

  • 5 diseases for FGFR1OP:    
    About MalaCards
    myeloproliferative disorder    steroid-induced glaucoma    8p11 myeloproliferative syndrome    vitiligo
    graves' disease

    1 disease from the University of Copenhagen DISEASES database for FGFR1OP:
    steroid-induced glaucoma

    Find genes that share disorders with FGFR1OP           About GenesLikeMe

    1 Novoseek inferred disease relationship for FGFR1OP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloproliferative disorders 69.1 1 9949182 (1)

    Genetic Association Database (GAD): FGFR1OP
    Human Genome Epidemiology (HuGE) Navigator: FGFR1OP (5 documents)

    Export disorders for FGFR1OP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGFR1OP gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with FGFR1OP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. (PubMed id 9949182)1, 2, 3, 9 Popovici C.... Pebusque M.-J. (Blood 1999)
    2. Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. (PubMed id 16690081)1, 2, 9 Mikolajka A....Holak T.A. (J. Mol. Biol. 2006)
    3. A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. (PubMed id 16314388)1, 2, 9 Yan X.... Nigg E.A. (Mol. Biol. Cell 2006)
    4. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. (PubMed id 20570966)1, 4 McGovern D.P....Rotter J.I. (Hum. Mol. Genet. 2010)
    5. Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. (PubMed id 20526339)1, 4 Quan C....Zhang X.J. (Nat. Genet. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. (PubMed id 19068216)1, 4 Anderson C.A....Parkes M. (Gastroenterology 2009)
    8. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. (PubMed id 18587394)1, 4 Barrett J.C....Daly M.J. (Nat. Genet. 2008)
    9. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11116 HGNC: 17012 AceView: CCR6 Ensembl:ENSG00000213066 euGenes: HUgn11116
    ECgene: FGFR1OP H-InvDB: FGFR1OP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FGFR1OP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGFR1OP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FGFR1OP gene:
    Search GeneIP for patents involving FGFR1OP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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