Aliases for FGFR1OP Gene
External Ids for FGFR1OP Gene
Previous GeneCards Identifiers for FGFR1OP Gene
This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
GeneCards Summary for FGFR1OP Gene
FGFR1OP (FGFR1 Oncogene Partner) is a Protein Coding gene. Diseases associated with FGFR1OP include steroid-induced glaucoma and 8p11 myeloproliferative syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR1 mutants. GO annotations related to this gene include protein homodimerization activity and protein tyrosine kinase activity.
UniProtKB/Swiss-Prot for FGFR1OP Gene
Required for anchoring microtubules to the centrosomes.