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Aliases for FGFBP3 Gene

Aliases for FGFBP3 Gene

  • Fibroblast Growth Factor Binding Protein 3 2 3 5
  • FGF-Binding Protein 3 3 4
  • C10orf13 3 4
  • FGF-BP3 3 4
  • FGFBP-3 3 4
  • Chromosome 10 Open Reading Frame 13 2

External Ids for FGFBP3 Gene

Previous HGNC Symbols for FGFBP3 Gene

  • C10orf13

Previous GeneCards Identifiers for FGFBP3 Gene

  • GC10M093657
  • GC10M087295

Summaries for FGFBP3 Gene

GeneCards Summary for FGFBP3 Gene

FGFBP3 (Fibroblast Growth Factor Binding Protein 3) is a Protein Coding gene. Among its related pathways are SHC-mediated cascade-FGFR4 and Signaling by GPCR. GO annotations related to this gene include heparin binding and fibroblast growth factor binding.

UniProtKB/Swiss-Prot for FGFBP3 Gene

  • Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFBP3 Gene

Genomics for FGFBP3 Gene

Regulatory Elements for FGFBP3 Gene

Enhancers for FGFBP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FGFBP3 on UCSC Golden Path with GeneCards custom track

Promoters for FGFBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FGFBP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FGFBP3 Gene

Chromosome:
10
Start:
91,906,588 bp from pter
End:
91,909,501 bp from pter
Size:
2,914 bases
Orientation:
Minus strand

Genomic View for FGFBP3 Gene

Genes around FGFBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFBP3 Gene

Proteins for FGFBP3 Gene

  • Protein details for FGFBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAT2-FGFP3_HUMAN
    Recommended name:
    Fibroblast growth factor-binding protein 3
    Protein Accession:
    Q8TAT2
    Secondary Accessions:
    • B2RD68
    • Q8NBN0

    Protein attributes for FGFBP3 Gene

    Size:
    258 amino acids
    Molecular mass:
    27590 Da
    Quaternary structure:
    • Interacts with FGF2.

neXtProt entry for FGFBP3 Gene

Proteomics data for FGFBP3 Gene at MOPED

Post-translational modifications for FGFBP3 Gene

  • Glycosylation at Thr 158
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGFBP3 Gene

Domains & Families for FGFBP3 Gene

Protein Domains for FGFBP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FGFBP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAT2

UniProtKB/Swiss-Prot:

FGFP3_HUMAN :
  • Belongs to the fibroblast growth factor-binding protein family.
Family:
  • Belongs to the fibroblast growth factor-binding protein family.
genes like me logo Genes that share domains with FGFBP3: view

No data available for Gene Families for FGFBP3 Gene

Function for FGFBP3 Gene

Molecular function for FGFBP3 Gene

UniProtKB/Swiss-Prot Function:
Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.

Phenotypes for FGFBP3 Gene

genes like me logo Genes that share phenotypes with FGFBP3: view

Animal Models for FGFBP3 Gene

MGI Knock Outs for FGFBP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGFBP3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGFBP3 Gene

Localization for FGFBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFBP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGFBP3 Gene COMPARTMENTS Subcellular localization image for FGFBP3 gene
Compartment Confidence
extracellular 5
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for FGFBP3 Gene

Pathways & Interactions for FGFBP3 Gene

genes like me logo Genes that share pathways with FGFBP3: view

Interacting Proteins for FGFBP3 Gene

Gene Ontology (GO) - Biological Process for FGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway IGI 18669637
genes like me logo Genes that share ontologies with FGFBP3: view

No data available for SIGNOR curated interactions for FGFBP3 Gene

Drugs & Compounds for FGFBP3 Gene

No Compound Related Data Available

Transcripts for FGFBP3 Gene

mRNA/cDNA for FGFBP3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGFBP3 Gene

Fibroblast growth factor binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGFBP3 Gene

No ASD Table

Relevant External Links for FGFBP3 Gene

GeneLoc Exon Structure for
FGFBP3
ECgene alternative splicing isoforms for
FGFBP3

Expression for FGFBP3 Gene

mRNA expression in normal human tissues for FGFBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FGFBP3 Gene

This gene is overexpressed in Fetal gut (32.4), Heart (20.9), and Fetal Brain (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGFBP3 Gene



SOURCE GeneReport for Unigene cluster for FGFBP3 Gene Hs.466120

genes like me logo Genes that share expression patterns with FGFBP3: view

Protein tissue co-expression partners for FGFBP3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FGFBP3 Gene

Orthologs for FGFBP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGFBP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGFBP3 35
  • 81.82 (n)
  • 72.29 (a)
FGFBP3 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGFBP3 35
  • 82.55 (n)
  • 74.47 (a)
FGFBP3 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgfbp3 35
  • 70.97 (n)
  • 59.45 (a)
Fgfbp3 16
Fgfbp3 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGFBP3 35
  • 99.1 (n)
  • 98.05 (a)
FGFBP3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgfbp3 35
  • 73.58 (n)
  • 58.53 (a)
chicken
(Gallus gallus)
Aves FGFBP3 35
  • 63.04 (n)
  • 52.17 (a)
lizard
(Anolis carolinensis)
Reptilia FGFBP3 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfbp3 35
  • 44.85 (n)
  • 35.08 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:165461 35
  • 47.81 (n)
  • 33.71 (a)
FGFBP3 36
  • 23 (a)
OneToOne
Species with no ortholog for FGFBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGFBP3 Gene

ENSEMBL:
Gene Tree for FGFBP3 (if available)
TreeFam:
Gene Tree for FGFBP3 (if available)

Paralogs for FGFBP3 Gene

No data available for Paralogs for FGFBP3 Gene

Variants for FGFBP3 Gene

Sequence variations from dbSNP and Humsavar for FGFBP3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1107947 - 91,908,353(-) CAACG(A/T)GGGCA reference, missense
rs10881994 - 91,908,651(+) GTGCG(C/T)GCGGC reference, missense
rs1890897 -- 91,907,878(-) CAGAG(A/G)GAGGC utr-variant-3-prime
rs3197263 -- 91,909,590(+) ctctc(C/T)ctctc upstream-variant-2KB
rs3204190 -- 91,909,169(+) ACCCT(C/T)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGFBP3 Gene

Variant ID Type Subtype PubMed ID
nsv7491 CNV Loss 18451855
esv22161 CNV Loss 19812545

Variation tolerance for FGFBP3 Gene

Gene Damage Index Score: 5.70; 73.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGFBP3 Gene

HapMap Linkage Disequilibrium report
FGFBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP3 Gene

Disorders for FGFBP3 Gene

Relevant External Links for FGFBP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGFBP3

No disorders were found for FGFBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGFBP3 Gene

Publications for FGFBP3 Gene

  1. Effect of FGF-binding protein 3 on vascular permeability. (PMID: 18669637) Zhang W. … Wellstein A. (J. Biol. Chem. 2008) 3 4 67
  2. Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. (PMID: 23658023) Soteriou D. … Kimber S.J. (J. Biol. Chem. 2013) 3
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for FGFBP3 Gene

Sources for FGFBP3 Gene

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