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Aliases for FGFBP3 Gene

Aliases for FGFBP3 Gene

  • Fibroblast Growth Factor Binding Protein 3 2 3
  • FGF-Binding Protein 3 3 4
  • C10orf13 3 4
  • FGF-BP3 3 4
  • FGFBP-3 3 4
  • Fibroblast Growth Factor-Binding Protein 3 3
  • Chromosome 10 Open Reading Frame 13 2

External Ids for FGFBP3 Gene

Previous HGNC Symbols for FGFBP3 Gene

  • C10orf13

Previous GeneCards Identifiers for FGFBP3 Gene

  • GC10M093657
  • GC10M087295

Summaries for FGFBP3 Gene

GeneCards Summary for FGFBP3 Gene

FGFBP3 (Fibroblast Growth Factor Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include heparin binding and fibroblast growth factor binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFBP3 Gene

Genomics for FGFBP3 Gene

Regulatory Elements for FGFBP3 Gene

Genomic Location for FGFBP3 Gene

Start:
91,906,588 bp from pter
End:
91,909,501 bp from pter
Size:
2,914 bases
Orientation:
Minus strand

Genomic View for FGFBP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGFBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFBP3 Gene

Proteins for FGFBP3 Gene

  • Protein details for FGFBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAT2-FGFP3_HUMAN
    Recommended name:
    Fibroblast growth factor-binding protein 3
    Protein Accession:
    Q8TAT2
    Secondary Accessions:
    • B2RD68
    • Q8NBN0

    Protein attributes for FGFBP3 Gene

    Size:
    258 amino acids
    Molecular mass:
    27590 Da
    Quaternary structure:
    • Interacts with FGF1.

neXtProt entry for FGFBP3 Gene

Proteomics data for FGFBP3 Gene at MOPED

Post-translational modifications for FGFBP3 Gene

  • Glycosylation at Thr158
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGFBP3 Gene

Domains for FGFBP3 Gene

Protein Domains for FGFBP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FGFBP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAT2

UniProtKB/Swiss-Prot:

FGFP3_HUMAN :
  • Q8TAT2
Family:
  • Belongs to the fibroblast growth factor-binding protein family.
genes like me logo Genes that share domains with FGFBP3: view

No data available for Gene Families for FGFBP3 Gene

Function for FGFBP3 Gene

Gene Ontology (GO) - Molecular Function for FGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IDA 18669637
GO:0017134 fibroblast growth factor binding IPI 18669637
genes like me logo Genes that share ontologies with FGFBP3: view

Phenotypes for FGFBP3 Gene

MGI mutant phenotypes for FGFBP3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with FGFBP3: view

Animal Model Products

CRISPR Products

miRNA for FGFBP3 Gene

miRTarBase miRNAs that target FGFBP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGFBP3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FGFBP3 Gene

Localization for FGFBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFBP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGFBP3 Gene COMPARTMENTS Subcellular localization image for FGFBP3 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for FGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 18669637
GO:0031012 extracellular matrix IDA 23658023
genes like me logo Genes that share ontologies with FGFBP3: view

Pathways for FGFBP3 Gene

SuperPathways for FGFBP3 Gene

No Data Available

Interacting Proteins for FGFBP3 Gene

Gene Ontology (GO) - Biological Process for FGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043117 positive regulation of vascular permeability IDA 18669637
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway IGI 18669637
genes like me logo Genes that share ontologies with FGFBP3: view

No data available for Pathways by source for FGFBP3 Gene

Transcripts for FGFBP3 Gene

mRNA/cDNA for FGFBP3 Gene

(34) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGFBP3 Gene

Fibroblast growth factor binding protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGFBP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFBP3 Gene

No ASD Table

Relevant External Links for FGFBP3 Gene

GeneLoc Exon Structure for
FGFBP3
ECgene alternative splicing isoforms for
FGFBP3

Expression for FGFBP3 Gene

mRNA expression in normal human tissues for FGFBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FGFBP3 Gene

SOURCE GeneReport for Unigene cluster for FGFBP3 Gene Hs.466120

genes like me logo Genes that share expressions with FGFBP3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FGFBP3 Gene

Orthologs for FGFBP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGFBP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGFBP3 35
  • 99.1 (n)
  • 98.05 (a)
FGFBP3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGFBP3 35
  • 81.82 (n)
  • 72.29 (a)
FGFBP3 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGFBP3 35
  • 82.55 (n)
  • 74.47 (a)
FGFBP3 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgfbp3 35
  • 70.97 (n)
  • 59.45 (a)
Fgfbp3 16
Fgfbp3 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgfbp3 35
  • 73.58 (n)
  • 58.53 (a)
chicken
(Gallus gallus)
Aves FGFBP3 35
  • 63.04 (n)
  • 52.17 (a)
lizard
(Anolis carolinensis)
Reptilia FGFBP3 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfbp3 35
  • 44.85 (n)
  • 35.08 (a)
zebrafish
(Danio rerio)
Actinopterygii FGFBP3 36
  • 23 (a)
OneToOne
zgc:165461 35
  • 47.81 (n)
  • 33.71 (a)
Species with no ortholog for FGFBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGFBP3 Gene

ENSEMBL:
Gene Tree for FGFBP3 (if available)
TreeFam:
Gene Tree for FGFBP3 (if available)

Paralogs for FGFBP3 Gene

No data available for Paralogs for FGFBP3 Gene

Variants for FGFBP3 Gene

Sequence variations from dbSNP and Humsavar for FGFBP3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1107947 - 91,908,353(-) CAACG(A/T)GGGCA reference, missense
rs1890897 -- 91,907,878(-) CAGAG(A/G)GAGGC utr-variant-3-prime
rs3197263 -- 91,909,590(+) ctctc(C/T)ctctc upstream-variant-2KB
rs3204190 -- 91,909,169(+) ACCCT(C/T)TGAGG intron-variant
rs3204191 -- 91,909,265(+) ATAGC(A/G)AAACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGFBP3 Gene

Variant ID Type Subtype PubMed ID
nsv7491 CNV Loss 18451855
esv22161 CNV Loss 19812545

Relevant External Links for FGFBP3 Gene

HapMap Linkage Disequilibrium report
FGFBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP3 Gene

Disorders for FGFBP3 Gene

No disorders were found for FGFBP3 Gene.

No data available for UniProtKB/Swiss-Prot for FGFBP3 Gene

Publications for FGFBP3 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. Effect of FGF-binding protein 3 on vascular permeability. (PMID: 18669637) Zhang W. … Wellstein A. (J. Biol. Chem. 2008) 3
  5. Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. (PMID: 23658023) Soteriou D. … Kimber S.J. (J. Biol. Chem. 2013) 3

Products for FGFBP3 Gene

Sources for FGFBP3 Gene

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