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Aliases for FGFBP3 Gene

Aliases for FGFBP3 Gene

  • Fibroblast Growth Factor Binding Protein 3 2 3 5
  • FGF-Binding Protein 3 3 4
  • C10orf13 3 4
  • FGF-BP3 3 4
  • FGFBP-3 3 4
  • Fibroblast Growth Factor-Binding Protein 3 3
  • Chromosome 10 Open Reading Frame 13 2

External Ids for FGFBP3 Gene

Previous HGNC Symbols for FGFBP3 Gene

  • C10orf13

Previous GeneCards Identifiers for FGFBP3 Gene

  • GC10M093657
  • GC10M087295

Summaries for FGFBP3 Gene

GeneCards Summary for FGFBP3 Gene

FGFBP3 (Fibroblast Growth Factor Binding Protein 3) is a Protein Coding gene. Among its related pathways are Signaling by FGFR2 and Signaling by GPCR. GO annotations related to this gene include heparin binding and fibroblast growth factor binding.

UniProtKB/Swiss-Prot for FGFBP3 Gene

  • Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFBP3 Gene

Genomics for FGFBP3 Gene

Regulatory Elements for FGFBP3 Gene

Enhancers for FGFBP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G091607 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21 +300.7 300733 2.6 PKNOX1 CREB3L1 ARNT DMAP1 YY1 ZNF766 ZNF416 DEK MCM3 REST RPP30 PPP1R3C FGFBP3 BTAF1 TNKS2-AS1 HECTD2 TNKS2 HECTD2-AS1 LOC105378433
GH10G091587 2.1 VISTA Ensembl ENCODE dbSUPER 10.2 +318.3 318282 7.3 PKNOX1 FOXA2 SIN3A FEZF1 ZNF766 ZNF548 FOS JUNB REST SMARCB1 RPP30 BTAF1 TNKS2-AS1 FGFBP3 HECTD2 PPP1R3C TNKS2 HECTD2-AS1 LOC105378433
GH10G092387 0.8 ENCODE 10.4 -478.0 -477988 0.2 HDAC1 PKNOX1 ATF1 ARID4B SIN3A ZSCAN9 CHAMP1 SLC30A9 ZNF766 EGR1 FGFBP3 CPEB3 MARK2P9 GC10P092357
GH10G091907 1.1 ENCODE 6.9 +0.9 888 2.2 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 ZNF263 FGFBP3 TNKS2 ENSG00000272817
GH10G091900 1.2 Ensembl ENCODE 6.1 +7.6 7561 2.4 FOXA2 ATF1 ZFP64 ARID4B FEZF1 BRCA1 YY1 GATA2 FOS JUNB TNKS2 FGFBP3 EXOC6 EIF2S2P3 ENSG00000272817 ENSG00000273497
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGFBP3 on UCSC Golden Path with GeneCards custom track

Promoters for FGFBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000031616 701 2001 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207

Genomic Location for FGFBP3 Gene

Chromosome:
10
Start:
91,906,588 bp from pter
End:
91,909,501 bp from pter
Size:
2,914 bases
Orientation:
Minus strand

Genomic View for FGFBP3 Gene

Genes around FGFBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFBP3 Gene

Proteins for FGFBP3 Gene

  • Protein details for FGFBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAT2-FGFP3_HUMAN
    Recommended name:
    Fibroblast growth factor-binding protein 3
    Protein Accession:
    Q8TAT2
    Secondary Accessions:
    • B2RD68
    • Q8NBN0

    Protein attributes for FGFBP3 Gene

    Size:
    258 amino acids
    Molecular mass:
    27590 Da
    Quaternary structure:
    • Interacts with FGF2.

neXtProt entry for FGFBP3 Gene

Post-translational modifications for FGFBP3 Gene

  • Glycosylation at Thr158
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGFBP3 Gene

Domains & Families for FGFBP3 Gene

Protein Domains for FGFBP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FGFBP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAT2

UniProtKB/Swiss-Prot:

FGFP3_HUMAN :
  • Belongs to the fibroblast growth factor-binding protein family.
Family:
  • Belongs to the fibroblast growth factor-binding protein family.
genes like me logo Genes that share domains with FGFBP3: view

No data available for Gene Families for FGFBP3 Gene

Function for FGFBP3 Gene

Molecular function for FGFBP3 Gene

UniProtKB/Swiss-Prot Function:
Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.

Gene Ontology (GO) - Molecular Function for FGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IDA 18669637
GO:0017134 fibroblast growth factor binding IPI 18669637
GO:0019838 growth factor binding IEA --
genes like me logo Genes that share ontologies with FGFBP3: view

Phenotypes for FGFBP3 Gene

genes like me logo Genes that share phenotypes with FGFBP3: view

Animal Models for FGFBP3 Gene

MGI Knock Outs for FGFBP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGFBP3

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGFBP3 Gene

Localization for FGFBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFBP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFBP3 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for FGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 18669637
GO:0031012 extracellular matrix IDA 23658023
genes like me logo Genes that share ontologies with FGFBP3: view

Pathways & Interactions for FGFBP3 Gene

genes like me logo Genes that share pathways with FGFBP3: view

Gene Ontology (GO) - Biological Process for FGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043117 positive regulation of vascular permeability IDA 18669637
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway IGI 18669637
genes like me logo Genes that share ontologies with FGFBP3: view

No data available for SIGNOR curated interactions for FGFBP3 Gene

Drugs & Compounds for FGFBP3 Gene

No Compound Related Data Available

Transcripts for FGFBP3 Gene

mRNA/cDNA for FGFBP3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGFBP3 Gene

Fibroblast growth factor binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFBP3 Gene

No ASD Table

Relevant External Links for FGFBP3 Gene

GeneLoc Exon Structure for
FGFBP3
ECgene alternative splicing isoforms for
FGFBP3

Expression for FGFBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGFBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FGFBP3 Gene

This gene is overexpressed in Fetal gut (32.4), Heart (20.9), and Fetal Brain (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGFBP3 Gene



Protein tissue co-expression partners for FGFBP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FGFBP3 Gene:

FGFBP3

SOURCE GeneReport for Unigene cluster for FGFBP3 Gene:

Hs.466120

Evidence on tissue expression from TISSUES for FGFBP3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FGFBP3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFBP3 Gene

Orthologs for FGFBP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGFBP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGFBP3 34 35
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia FGFBP3 34 35
  • 82.55 (n)
cow
(Bos Taurus)
Mammalia FGFBP3 34 35
  • 81.82 (n)
rat
(Rattus norvegicus)
Mammalia Fgfbp3 34
  • 73.58 (n)
mouse
(Mus musculus)
Mammalia Fgfbp3 34 16 35
  • 70.97 (n)
chicken
(Gallus gallus)
Aves FGFBP3 34
  • 63.04 (n)
lizard
(Anolis carolinensis)
Reptilia FGFBP3 35
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfbp3 34
  • 44.85 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:165461 34
  • 47.81 (n)
FGFBP3 35
  • 23 (a)
OneToOne
Species where no ortholog for FGFBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGFBP3 Gene

ENSEMBL:
Gene Tree for FGFBP3 (if available)
TreeFam:
Gene Tree for FGFBP3 (if available)

Paralogs for FGFBP3 Gene

No data available for Paralogs for FGFBP3 Gene

Variants for FGFBP3 Gene

Sequence variations from dbSNP and Humsavar for FGFBP3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1001369496 -- 91,907,533(+) TGTCA(-/G)GGGAA utr-variant-3-prime
rs1002364309 -- 91,909,166(+) GAGAC(C/T)CTCTG intron-variant
rs1002880509 -- 91,910,429(+) TGAGA(C/T)GGGAG upstream-variant-2KB
rs1003176829 -- 91,907,411(+) CTACT(C/T)CTAGC utr-variant-3-prime
rs1003314074 -- 91,907,189(+) ATTTC(A/G/T)TTAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FGFBP3 Gene

Variant ID Type Subtype PubMed ID
esv22161 CNV loss 19812545
nsv551921 CNV gain 21841781
nsv551922 CNV loss 21841781
nsv7491 CNV deletion 18451855

Variation tolerance for FGFBP3 Gene

Gene Damage Index Score: 5.70; 73.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGFBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGFBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP3 Gene

Disorders for FGFBP3 Gene

Relevant External Links for FGFBP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGFBP3

No disorders were found for FGFBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGFBP3 Gene

Publications for FGFBP3 Gene

  1. Effect of FGF-binding protein 3 on vascular permeability. (PMID: 18669637) Zhang W. … Wellstein A. (J. Biol. Chem. 2008) 3 4 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. (PMID: 23658023) Soteriou D. … Kimber S.J. (J. Biol. Chem. 2013) 3 64

Products for FGFBP3 Gene

Sources for FGFBP3 Gene

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