Aliases for FGFBP3 Gene
Aliases for FGFBP3 Gene
External Ids for FGFBP3 Gene
- HGNC: 23428
- Entrez Gene: 143282
- Ensembl: ENSG00000174721
- UniProtKB: Q8TAT2
Previous HGNC Symbols for FGFBP3 Gene
- C10orf13
Previous GeneCards Identifiers for FGFBP3 Gene
- GC10M093657
- GC10M087295
Summaries for FGFBP3 Gene
GeneCards Summary for FGFBP3 Gene
FGFBP3 (Fibroblast Growth Factor Binding Protein 3) is a Protein Coding gene. Among its related pathways are Signaling by FGFR2 and Signaling by GPCR. GO annotations related to this gene include heparin binding and fibroblast growth factor binding.
UniProtKB/Swiss-Prot for FGFBP3 Gene
-
Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFBP3 Gene
Genomics for FGFBP3 Gene
Regulatory Elements for FGFBP3 Gene
- Transcription factor binding sites by QIAGEN in the FGFBP3 gene promoter:
Regulatory Element Products
Genomic Location for FGFBP3 Gene
- Chromosome:
- 10
- Start:
- 91,906,588 bp from pter
- End:
- 91,909,501 bp from pter
- Size:
- 2,914 bases
- Orientation:
- Minus strand
Genomic View for FGFBP3 Gene
- Cytogenetic band:
-
- 10q23.32 by Ensembl
- 10q23.32 by Entrez Gene
- 10q23.32 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGFBP3 Gene
Proteins for FGFBP3 Gene
-
Protein details for FGFBP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TAT2-FGFP3_HUMAN
- Recommended name:
- Fibroblast growth factor-binding protein 3
- Protein Accession:
- Q8TAT2
- B2RD68
- Q8NBN0
Protein attributes for FGFBP3 Gene
- Size:
- 258 amino acids
- Molecular mass:
- 27590 Da
- Quaternary structure:
-
- Interacts with FGF2.
Protein Expression for FGFBP3 Gene
Post-translational modifications for FGFBP3 Gene
Other Protein References for FGFBP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FGFBP3
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Protein Products
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- Novus Biologicals proteins for FGFBP3
- Sino Biological Recombinant Proteins for FGFBP3
- Sino Biological Cell Lysates for FGFBP3
- Search GeneTex for Proteins for FGFBP3
Assay Products
No data available for DME Specific Peptides for FGFBP3 Gene
Domains & Families for FGFBP3 Gene
Suggested Antigen Peptide Sequences for FGFBP3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TAT2- Family:
-
- Belongs to the fibroblast growth factor-binding protein family.
No data available for Gene Families for FGFBP3 Gene
Function for FGFBP3 Gene
Molecular function for FGFBP3 Gene
- UniProtKB/Swiss-Prot Function:
- Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008201 | heparin binding | IDA | 18669637 |
| GO:0017134 | fibroblast growth factor binding | IPI | 18669637 |
| GO:0019838 | growth factor binding | IEA | -- |
Phenotypes for FGFBP3 Gene
- MGI mutant phenotypes for FGFBP3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FGFBP3:
Animal Model Products
-
Taconic Biosciences Mouse Models for FGFBP3
-
ViGene Biosciences lentiviral particle packaged cDNA for FGFBP3 gene
- Search ViGene Biosciences for FGFBP3
CRISPR Products
-
OriGene CRISPR knockouts for FGFBP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGFBP3
- GenScript: Design CRISPR guide RNA sequences for FGFBP3
miRNA for FGFBP3 Gene
- miRTarBase miRNAs that target FGFBP3
-
- hsa-mir-335-5p (MIRT018530)
- hsa-mir-484 (MIRT042123)
- hsa-mir-6083 (MIRT614381)
- hsa-mir-190a-3p (MIRT614382)
- hsa-mir-3941 (MIRT614383)
- hsa-mir-4729 (MIRT614384)
- hsa-mir-5011-5p (MIRT614385)
- hsa-mir-603 (MIRT614386)
- hsa-mir-362-3p (MIRT614387)
- hsa-mir-329-3p (MIRT614388)
- hsa-mir-8485 (MIRT614389)
- hsa-mir-5690 (MIRT620375)
- hsa-mir-7977 (MIRT620376)
- hsa-mir-5588-3p (MIRT620377)
- hsa-mir-2114-5p (MIRT620378)
- hsa-mir-483-3p (MIRT620379)
- hsa-mir-26a-2-3p (MIRT664077)
- hsa-mir-26a-1-3p (MIRT664078)
miRNA Products
- Search ViGene Biosciences for FGFBP3
Inhibitory RNA Products
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Clone Products
-
OriGene ORF clones in human for FGFBP3
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Cell Line Products
-
Horizon Cell Lines for FGFBP3
-
ViGene Biosciences adenoviral particle packaged cDNA for FGFBP3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FGFBP3 gene
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGFBP3 Gene
Localization for FGFBP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGFBP3 Gene
- Secreted.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA | 18669637 |
| GO:0031012 | extracellular matrix | IDA | 23658023 |
Pathways & Interactions for FGFBP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by FGFR2 | ||
| 2 | Signaling by GPCR | ||
Pathways by source for FGFBP3 Gene
5 Reactome pathways for FGFBP3 Gene
Interacting Proteins for FGFBP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0043117 | positive regulation of vascular permeability | IDA | 18669637 |
| GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway | IGI | 18669637 |
No data available for SIGNOR curated interactions for FGFBP3 Gene
Transcripts for FGFBP3 Gene
mRNA/cDNA for FGFBP3 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGFBP3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FGFBP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGFBP3
- GenScript: Design CRISPR guide RNA sequences for FGFBP3
miRNA Products
- Search ViGene Biosciences for FGFBP3
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for FGFBP3
- Browse OriGene Inhibitory RNA Products For FGFBP3
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Clone Products
-
OriGene ORF clones in human for FGFBP3
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Flow Cytometry Products
Expression for FGFBP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Glial Cells
- Protoplasmic Astrocyte Cells Neocortex
-
Spinal Cord (Nervous System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGFBP3 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGFBP3 Gene:
FGFBP3SOURCE GeneReport for Unigene cluster for FGFBP3 Gene:
Hs.466120Evidence on tissue expression from TISSUES for FGFBP3 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for FGFBP3
-
OriGene qPCR primer pairs for FGFBP3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFBP3 Gene
Orthologs for FGFBP3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGFBP3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FGFBP3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FGFBP3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fgfbp3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fgfbp3 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | FGFBP3 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FGFBP3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgfbp3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:165461 34 |
|
||
| FGFBP3 35 |
|
OneToOne |
- Species where no ortholog for FGFBP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGFBP3 Gene
No data available for Paralogs for FGFBP3 Gene
Variants for FGFBP3 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001369496 | -- | 91,907,533(+) | TGTCA(-/G)GGGAA | utr-variant-3-prime | |
| rs1002364309 | -- | 91,909,166(+) | GAGAC(C/T)CTCTG | intron-variant | |
| rs1002880509 | -- | 91,910,429(+) | TGAGA(C/T)GGGAG | upstream-variant-2KB | |
| rs1003176829 | -- | 91,907,411(+) | CTACT(C/T)CTAGC | utr-variant-3-prime | |
| rs1003314074 | -- | 91,907,189(+) | ATTTC(A/G/T)TTAAA | utr-variant-3-prime |
Relevant External Links for FGFBP3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FGFBP3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP3 Gene
Disorders for FGFBP3 Gene
Relevant External Links for FGFBP3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FGFBP3
No disorders were found for FGFBP3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGFBP3 Gene
Publications for FGFBP3 Gene
- Effect of FGF-binding protein 3 on vascular permeability. (PMID: 18669637) Zhang W. … Wellstein A. (J. Biol. Chem. 2008) 3 4 64
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. (PMID: 23658023) Soteriou D. … Kimber S.J. (J. Biol. Chem. 2013) 3 64
Products for FGFBP3 Gene
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- Custom Antibody ServicesOriGene Antibodies for FGFBP3
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- Taconic Biosciences Mouse Models for FGFBP3
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- Genetically Engineered Models Available Immediately
- Humanized Mice
- ViGene Biosciences adenoviral particle packaged cDNA for FGFBP3 gene
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- Horizon Cell Lines for FGFBP3
- Cyagen custom Knockout/knockin (KOKI) mouse models for FGFBP3
- VectorBuilder custom plasmid, inducible vectors for FGFBP3
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FGFBP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
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- (62) NCBI
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- (64) PubMed
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- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
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- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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- (100) COMPARTMENTS
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- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (155) Gene ORGANizer




