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Aliases for FGFBP2 Gene

Aliases for FGFBP2 Gene

  • Fibroblast Growth Factor Binding Protein 2 2 3
  • KSP37 3 4 6
  • Killer-Specific Secretory Protein Of 37 KDa 2 3
  • 37 KDa Killer-Specific Secretory Protein 3 4
  • FGF-Binding Protein 2 3 4
  • HBp17-Related Protein 3 4
  • HBp17-RP 3 4
  • FGF-BP2 3 4
  • FGFBP-2 3 4
  • Fibroblast Growth Factor-Binding Protein 2 3
  • HBP17RP 3

External Ids for FGFBP2 Gene

Summaries for FGFBP2 Gene

Entrez Gene Summary for FGFBP2 Gene

  • This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008]

GeneCards Summary for FGFBP2 Gene

FGFBP2 (Fibroblast Growth Factor Binding Protein 2) is a Protein Coding gene. Diseases associated with FGFBP2 include asthma. GO annotations related to this gene include growth factor binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFBP2 Gene

Genomics for FGFBP2 Gene

Genomic Location for FGFBP2 Gene

Start:
15,960,240 bp from pter
End:
15,969,309 bp from pter
Size:
9,070 bases
Orientation:
Minus strand

Genomic View for FGFBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGFBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFBP2 Gene

Regulatory Elements for FGFBP2 Gene

Proteins for FGFBP2 Gene

  • Protein details for FGFBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYJ0-FGFP2_HUMAN
    Recommended name:
    Fibroblast growth factor-binding protein 2
    Protein Accession:
    Q9BYJ0
    Secondary Accessions:

    Protein attributes for FGFBP2 Gene

    Size:
    223 amino acids
    Molecular mass:
    24581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FGFBP2 Gene

Proteomics data for FGFBP2 Gene at MOPED

Post-translational modifications for FGFBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser136, Thr147, Ser149, Thr155, Thr159, and Thr162

Other Protein References for FGFBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGFBP2 Gene

Domains for FGFBP2 Gene

Protein Domains for FGFBP2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FGFP2_HUMAN
Family:
  • Belongs to the fibroblast growth factor-binding protein family.:
    • Q9BYJ0
genes like me logo Genes that share domains with FGFBP2: view

No data available for Gene Families for FGFBP2 Gene

Function for FGFBP2 Gene

Gene Ontology (GO) - Molecular Function for FGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019838 growth factor binding IEA --
genes like me logo Genes that share ontologies with FGFBP2: view

Phenotypes for FGFBP2 Gene

GenomeRNAi human phenotypes for FGFBP2:
genes like me logo Genes that share phenotypes with FGFBP2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FGFBP2 Gene

Localization for FGFBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFBP2 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGFBP2 Gene COMPARTMENTS Subcellular localization image for FGFBP2 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with FGFBP2: view

Pathways for FGFBP2 Gene

SuperPathways for FGFBP2 Gene

No Data Available

Interacting Proteins for FGFBP2 Gene

Gene Ontology (GO) - Biological Process for FGFBP2 Gene

None

No data available for Pathways by source for FGFBP2 Gene

Transcripts for FGFBP2 Gene

mRNA/cDNA for FGFBP2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGFBP2 Gene

Fibroblast growth factor binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGFBP2 Gene

No ASD Table

Relevant External Links for FGFBP2 Gene

GeneLoc Exon Structure for
FGFBP2
ECgene alternative splicing isoforms for
FGFBP2

Expression for FGFBP2 Gene

mRNA expression in normal human tissues for FGFBP2 Gene

mRNA differential expression in normal tissues according to GTEx for FGFBP2 Gene

This gene is overexpressed in Whole Blood (15.6) and Nerve - Tibial (13.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FGFBP2 Gene

SOURCE GeneReport for Unigene cluster for FGFBP2 Gene Hs.98785

mRNA Expression by UniProt/SwissProt for FGFBP2 Gene

Q9BYJ0-FGFP2_HUMAN
Tissue specificity: Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at protein level).
genes like me logo Genes that share expressions with FGFBP2: view

Orthologs for FGFBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGFBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGFBP2 36
  • 98.65 (n)
  • 99.1 (a)
FGFBP2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGFBP2 37
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGFBP2 36
  • 54.75 (n)
  • 43 (a)
FGFBP2 37
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGFBP2 37
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfbp2 36
  • 47.97 (n)
  • 36.51 (a)
zebrafish
(Danio rerio)
Actinopterygii fgfbp2a 37
  • 26 (a)
OneToMany
fgfbp2b 36
  • 49.75 (n)
  • 34.17 (a)
fgfbp2b 37
  • 21 (a)
OneToMany
Species with no ortholog for FGFBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGFBP2 Gene

ENSEMBL:
Gene Tree for FGFBP2 (if available)
TreeFam:
Gene Tree for FGFBP2 (if available)

Paralogs for FGFBP2 Gene

No data available for Paralogs for FGFBP2 Gene

Variants for FGFBP2 Gene

Sequence variations from dbSNP and Humsavar for FGFBP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs758328 -- 15,962,950(-) CTTCG(C/T)GTCGA synonymous-codon, reference
rs758329 - 15,962,862(-) CCAAA(C/T)CTTAC reference, missense
rs1541458 -- 15,965,217(-) ACCCT(A/G)AGTCA upstream-variant-2KB
rs2286459 - 15,962,878(-) GCTTT(C/G/T)GCTGC reference, missense, synonymous-codon
rs2286460 -- 15,962,417(-) TTACT(C/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGFBP2 Gene

Variant ID Type Subtype PubMed ID
nsv527861 CNV Gain 19592680

Relevant External Links for FGFBP2 Gene

HapMap Linkage Disequilibrium report
FGFBP2

Disorders for FGFBP2 Gene

(1) MalaCards Diseases for FGFBP2 Gene

Search for FGFBP2 Gene in MalaCards »
genes like me logo Genes that share disorders with FGFBP2: view

No data available for UniProtKB/Swiss-Prot for FGFBP2 Gene

Publications for FGFBP2 Gene

  1. A novel serum protein that is selectively produced by cytotoxic lymphocytes. (PMID: 11342666) Ogawa K. … Nagata K. (J. Immunol. 2001) 2 3 4
  2. Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy. (PMID: 12322897) Hayano C. … Aso T. (Am. J. Reprod. Immunol. 2002) 2 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Increase in killer-specific secretory protein of 37 kDa in bronchoalveolar lavage fluid of allergen-challenged patients with atopic asthma. (PMID: 15898988) Kuepper M. … Virchow J.C. (Clin. Exp. Allergy 2005) 3

Products for FGFBP2 Gene

Sources for FGFBP2 Gene

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