Aliases for FGFBP2 Gene
Aliases for FGFBP2 Gene
External Ids for FGFBP2 Gene
- HGNC: 29451
- Entrez Gene: 83888
- Ensembl: ENSG00000137441
- OMIM: 607713
- UniProtKB: Q9BYJ0
Previous GeneCards Identifiers for FGFBP2 Gene
- GC04M015571
- GC04M015311
Summaries for FGFBP2 Gene
-
This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008]
GeneCards Summary for FGFBP2 Gene
FGFBP2 (Fibroblast Growth Factor Binding Protein 2) is a Protein Coding gene. Diseases associated with FGFBP2 include Asthma. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and SHC-mediated cascade-FGFR4. GO annotations related to this gene include growth factor binding.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFBP2 Gene
Genomics for FGFBP2 Gene
Regulatory Elements for FGFBP2 Gene
Enhancers for FGFBP2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around FGFBP2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FGFBP2 Gene
- Chromosome:
- 4
- Start:
- 15,960,240 bp from pter
- End:
- 15,969,309 bp from pter
- Size:
- 9,070 bases
- Orientation:
- Minus strand
Genomic View for FGFBP2 Gene
Genes around FGFBP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p15.32 by Ensembl
- 4p16 by Entrez Gene
- 4p15.32 by HGNC
FGFBP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGFBP2 Gene
Proteins for FGFBP2 Gene
-
Protein details for FGFBP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BYJ0-FGFP2_HUMAN
- Recommended name:
- Fibroblast growth factor-binding protein 2
- Protein Accession:
- Q9BYJ0
Protein attributes for FGFBP2 Gene
- Size:
- 223 amino acids
- Molecular mass:
- 24581 Da
- Quaternary structure:
- No Data Available
Protein Expression for FGFBP2 Gene
Post-translational modifications for FGFBP2 Gene
Other Protein References for FGFBP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FGFBP2
- Abcam antibodies for FGFBP2
- Invitrogen Antibodies for FGFBP2
- antibodies-online Antibodies for FGFBP2: See all 24
- Search GeneTex for Antibodies for FGFBP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGFBP2
Protein Products
-
OriGene Purified Proteins for FGFBP2
- Search Origene for MassSpec and Protein Over-expression Lysates for FGFBP2
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- antibodies-online Proteins for FGFBP2: See all 4
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- Abcam proteins for FGFBP2
Assay Products
- antibodies-online Kits for FGFBP2: See all 20
No data available for DME Specific Peptides for FGFBP2 Gene
Domains & Families for FGFBP2 Gene
Suggested Antigen Peptide Sequences for FGFBP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BYJ0- Family:
-
- Belongs to the fibroblast growth factor-binding protein family.
No data available for Gene Families for FGFBP2 Gene
Function for FGFBP2 Gene
Phenotypes for FGFBP2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FGFBP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
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CRISPR Products
-
OriGene CRISPR knockouts for FGFBP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGFBP2
- GenScript: Design CRISPR guide RNA sequences for FGFBP2
miRNA Products
- Search ViGene Biosciences for FGFBP2
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
Clone Products
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for FGFBP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FGFBP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FGFBP2 Gene
Localization for FGFBP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGFBP2 Gene
- Secreted, extracellular space.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
No data available for Gene Ontology (GO) - Cellular Components for FGFBP2 Gene
Pathways & Interactions for FGFBP2 Gene
More details on SuperPathways for FGFBP2| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | SHC-mediated cascade-FGFR4 | ||
| 2 | Interleukin-3, 5 and GM-CSF signaling | ||
| 3 | Signaling by GPCR |
Pathways by source for FGFBP2 Gene
5 Reactome pathways for FGFBP2 Gene
Interacting Proteins for FGFBP2 Gene
No data available for SIGNOR curated interactions for FGFBP2 Gene
Transcripts for FGFBP2 Gene
mRNA/cDNA for FGFBP2 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (45) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGFBP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FGFBP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGFBP2
- GenScript: Design CRISPR guide RNA sequences for FGFBP2
miRNA Products
- Search ViGene Biosciences for FGFBP2
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FGFBP2
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-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
Clone Products
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Flow Cytometry Products
Expression for FGFBP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
- Neural Crest (Gastrulation Derivatives)
mRNA differential expression in normal tissues according to GTEx for FGFBP2 Gene
This gene is overexpressed in Whole Blood (x15.6) and Nerve - Tibial (x13.0).
This gene is overexpressed in Synovial fluid (52.5) and Monocytes (12.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGFBP2 Gene
SOURCE GeneReport for Unigene cluster for FGFBP2 Gene Hs.98785
mRNA Expression by UniProt/SwissProt for FGFBP2 Gene
Q9BYJ0-FGFP2_HUMAN
Tissue specificity:
Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at protein level).
Primer Products
-
OriGene qPCR primer pairs for FGFBP2
No data available for Protein tissue co-expression partners for FGFBP2 Gene
Orthologs for FGFBP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGFBP2 35 |
|
||
| FGFBP2 36 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | FGFBP2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGFBP2 35 |
|
||
| FGFBP2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | FGFBP2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgfbp2 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgfbp2b 35 |
|
||
| fgfbp2a 36 |
|
OneToMany | |||
| fgfbp2b 36 |
|
OneToMany |
- Species with no ortholog for FGFBP2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGFBP2 Gene
No data available for Paralogs for FGFBP2 Gene
Variants for FGFBP2 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs758329 | - | 15,962,862(-) | CCAAA(A/C/T)CTTAC | reference, missense | |
| rs2286459 | - | 15,962,878(-) | GCTTT(C/G/T)GCTGC | reference, synonymous-codon | |
| rs35496730 | - | 15,963,047(+) | CAGTG(C/T)TTCCT | reference, missense | |
| rs758328 | -- | 15,962,950(-) | CTTCG(C/T)GTCGA | reference, synonymous-codon | |
| rs1541458 | -- | 15,965,217(-) | ACCCT(A/G)AGTCA | upstream-variant-2KB |
Residual Variation Intolerance Score:
85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.11;
80.52% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FGFBP2 Gene
Disorders for FGFBP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| asthma |
|
|
Search FGFBP2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FGFBP2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FGFBP2
No data available for UniProtKB/Swiss-Prot and Genatlas for FGFBP2 Gene
Publications for FGFBP2 Gene
- A novel serum protein that is selectively produced by cytotoxic lymphocytes. (PMID: 11342666) Ogawa K. … Nagata K. (J. Immunol. 2001) 2 3 4 67
- Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy. (PMID: 12322897) Hayano C. … Aso T. (Am. J. Reprod. Immunol. 2002) 2 3
- CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
- Generalization of Variants Identified by Genome-Wide Association Studies for Electrocardiographic Traits in African Americans. (PMID: 23534349) Jeff J.M. … Crawford D.C. (Ann. Hum. Genet. 2013) 3
- Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
Products for FGFBP2 Gene
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- Abcam antibodies for FGFBP2
- Abcam proteins for FGFBP2
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- antibodies-online Antibodies for FGFBP2: See all 24
- antibodies-online Kits for FGFBP2: See all 20
- antibodies-online Proteins for FGFBP2: See all 4
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- Search GeneTex for Antibodies for FGFBP2
- Search GeneTex for Proteins for FGFBP2
- ViGene Biosciences adenoviral particle packaged cDNA for FGFBP2 gene
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Sources for FGFBP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (11) GO
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- (30) ASD
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- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
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- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
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