Aliases for FGFBP2 Gene
Aliases for FGFBP2 Gene
External Ids for FGFBP2 Gene
- HGNC: 29451
- Entrez Gene: 83888
- Ensembl: ENSG00000137441
- OMIM: 607713
- UniProtKB: Q9BYJ0
Previous GeneCards Identifiers for FGFBP2 Gene
- GC04M015571
- GC04M015311
Summaries for FGFBP2 Gene
-
This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008]
GeneCards Summary for FGFBP2 Gene
FGFBP2 (Fibroblast Growth Factor Binding Protein 2) is a Protein Coding gene. Diseases associated with FGFBP2 include Asthma. Among its related pathways are Signaling by FGFR2 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include growth factor binding.
Additional gene information for FGFBP2 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFBP2 Gene
Genomics for FGFBP2 Gene
GeneHancer (GH) Regulatory Elements for FGFBP2 Gene
Promoters and enhancers for FGFBP2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04I015960 | Promoter/Enhancer | 1.3 | EPDnew Ensembl ENCODE | 574.7 | +6.9 | 6905 | 2.9 | CTCF ESRRA DPF2 RAD21 IKZF1 SMC3 ZNF143 ATF7 ZBTB33 IKZF2 | FGFBP2 GC04M015932 PROM1 | |
| GH04I015904 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 15.8 | +62.9 | 62877 | 4 | CTCF BCOR KLF1 FOXA2 JUN MAX ZMYM3 RFX5 E2F1 POLR2A | FGFBP1 FGFBP2 PROM1 CD38 FBXL5 BST1 HPRT1P1 | |
| GH04I015920 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 11.1 | +48.0 | 48015 | 2.2 | NFIB JUN INSM2 FOSL1 POLR2A RCOR1 CBFA2T2 FOSL2 FOS ZNF10 | FGFBP2 PROM1 FGFBP1 HPRT1P1 | |
| GH04I015808 | Enhancer | 1 | FANTOM5 Ensembl | 11.8 | +160.1 | 160108 | 1.2 | HDGF BACH1 BMI1 BATF IRF4 RELA NFATC1 ATF7 IKZF2 RUNX3 | CD38 FGFBP2 PROM1 BST1 GC04P015792 PIR31595 | |
| GH04I016001 | Enhancer | 0.9 | Ensembl ENCODE | 11.8 | -32.3 | -32290 | 0.6 | CTCF RB1 MAX RAD21 RELA TEAD3 POLR2A VEZF1 SMC3 ZNF143 | FGFBP2 PROM1 BST1 GC04M016016 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FGFBP2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FGFBP2 Gene
Genomic Locations for FGFBP2 Gene
- chr4:15,960,240-15,969,309
- (GRCh38/hg38)
- Size:
- 9,070 bases
- Orientation:
- Minus strand
- chr4:15,961,863-15,970,932
- (GRCh37/hg19)
Genomic View for FGFBP2 Gene
Genes around FGFBP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p15.32 by Ensembl
- 4p15.32 by Entrez Gene
- 4p15.32 by HGNC
FGFBP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGFBP2 Gene
Proteins for FGFBP2 Gene
-
Protein details for FGFBP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BYJ0-FGFP2_HUMAN
- Recommended name:
- Fibroblast growth factor-binding protein 2
- Protein Accession:
- Q9BYJ0
Protein attributes for FGFBP2 Gene
- Size:
- 223 amino acids
- Molecular mass:
- 24581 Da
- Quaternary structure:
- No Data Available
Protein Expression for FGFBP2 Gene
Post-translational modifications for FGFBP2 Gene
- Glycosylation at Ser136, posLast=159159, and Thr162
Other Protein References for FGFBP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FGFBP2 (FGFBP2)
-
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-
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Protein Products
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-
Quality Products:
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-
Abcam proteins for FGFBP2
Assay Products
No data available for DME Specific Peptides for FGFBP2 Gene
Domains & Families for FGFBP2 Gene
Gene Families for FGFBP2 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for FGFBP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BYJ0- Family:
-
- Belongs to the fibroblast growth factor-binding protein family.
Function for FGFBP2 Gene
Phenotypes From GWAS Catalog for FGFBP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019838 | growth factor binding | IEA | -- |
Phenotypes for FGFBP2 Gene
- GenomeRNAi human phenotypes for FGFBP2:
Animal Model Products
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-
-
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-
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CRISPR Products
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Inhibitory RNA Products
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- Overview of 49 available FGFBP2 gene related products
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Clone Products
- Sino Biological Human cDNA Clone for FGFBP2
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FGFBP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FGFBP2
-
ViGene Biosciences adenoviral particle packaged cDNA for FGFBP2 gene
-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FGFBP2 Gene
Localization for FGFBP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGFBP2 Gene
- Secreted, extracellular space.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGFBP2 Gene
Pathways & Interactions for FGFBP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by FGFR2 | ||
| 2 | Signaling by GPCR | ||
Pathways by source for FGFBP2 Gene
5 Reactome pathways for FGFBP2 Gene
Interacting Proteins for FGFBP2 Gene
No data available for SIGNOR curated interactions for FGFBP2 Gene
Transcripts for FGFBP2 Gene
mRNA/cDNA for FGFBP2 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (45) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGFBP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FGFBP2
- genomics-online: gRNA clones - Search results for 49 available FGFBP2 gene related products
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- Applied Biological Materials CRISPR for FGFBP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGFBP2
- GenScript: Design CRISPR guide RNA sequences for FGFBP2
miRNA Products
- Search ViGene Biosciences for FGFBP2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FGFBP2
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- genomics-online: shRNA clones - Search results for 49 available FGFBP2 gene related products
- Overview of 49 available FGFBP2 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
Clone Products
- Sino Biological Human cDNA Clone for FGFBP2
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- VectorBuilder custom plasmid, inducible vectors for FGFBP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FGFBP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FGFBP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FGFBP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
- Neural Crest (Gastrulation Derivatives)
mRNA differential expression in normal tissues according to GTEx for FGFBP2 Gene
This gene is overexpressed in Whole Blood (x15.6) and Nerve - Tibial (x13.0).
This gene is overexpressed in Synovial fluid (52.5) and Monocytes (12.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGFBP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGFBP2 Gene:
FGFBP2SOURCE GeneReport for Unigene cluster for FGFBP2 Gene:
Hs.98785mRNA Expression by UniProt/SwissProt for FGFBP2 Gene:
Q9BYJ0-FGFP2_HUMAN
Tissue specificity:
Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at protein level).
Evidence on tissue expression from TISSUES for FGFBP2 Gene
- Blood(4.3)
- Pancreas(4.2)
Primer Products
-
OriGene qPCR primer pairs for FGFBP2
- genomics-online: primer clones - Search results for 49 available FGFBP2 gene related products
- Overview of 49 available FGFBP2 gene related products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFBP2 Gene
Orthologs for FGFBP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGFBP2 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FGFBP2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGFBP2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FGFBP2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgfbp2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgfbp2b 33 34 |
|
||
| fgfbp2a 34 |
|
OneToMany |
- Species where no ortholog for FGFBP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGFBP2 Gene
No data available for Paralogs for FGFBP2 Gene
Variants for FGFBP2 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000592455 | -- | 15,961,938(-) | C/T | intron_variant | |
| rs1001061171 | -- | 15,961,588(-) | T/G | intron_variant | |
| rs1001247347 | -- | 15,965,186(-) | C/A | upstream_transcript_variant | |
| rs1001513821 | -- | 15,959,854(-) | T/G | downstream_transcript_variant | |
| rs1001866543 | -- | 15,961,037(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.11;
80.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FGFBP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FGFBP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP2 Gene
Disorders for FGFBP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| asthma |
|
|
Search FGFBP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FGFBP2
No data available for UniProtKB/Swiss-Prot and Genatlas for FGFBP2 Gene
Publications for FGFBP2 Gene
- A novel serum protein that is selectively produced by cytotoxic lymphocytes. (PMID: 11342666) Ogawa K … Nagata K (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
- Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy. (PMID: 12322897) Hayano C … Aso T (American journal of reproductive immunology (New York, N.Y. : 1989) 2002) 2 3 58
- Killer-specific secretory (Ksp37) gene expression in subjects with Down's syndrome. (PMID: 27032399) Salemi M … Romano C (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2016) 3 58
Products for FGFBP2 Gene
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- Invitrogen Antibodies for FGFBP2
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FGFBP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 30 available FGFBP2 Antibodies ranked by validation data
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- Overview of 49 available FGFBP2 gene related products
Sources for FGFBP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew