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FGFBP2 Gene

protein-coding GIFtS: 46
GCID: GC04M015961

Fibroblast Growth Factor Binding Protein 2

See FGFBP2-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Fibroblast Growth Factor Binding Protein 2¹ ²		HBp17-RP² ³
KSP37² ³ ⁵		FGF-Binding Protein 2² ³
Killer-Specific Secretory Protein Of 37 KDa¹ ²		HBp17-Related Protein² ³
37 KDa Killer-Specific Secretory Protein² ³		HBP17RP²
FGF-BP2² ³		Fibroblast Growth Factor-Binding Protein 2²
FGFBP-2² ³		Ksp37³

External Ids:	HGNC: 29451¹	Entrez Gene: 83888²	Ensembl: ENSG00000137441⁷	OMIM: 607713⁵	UniProtKB: Q9BYJ0³

ORGUL members:

Export aliases for FGFBP2 gene to outside databases

Previous GC identifers: GC04M015571 GC04M015311

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGFBP2 Gene:

This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum

protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic

lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and

mild extrinsic asthma.(provided by RefSeq Staff, Oct 2008)

GeneCards Summary for FGFBP2 Gene:

FGFBP2 (fibroblast growth factor binding protein 2) is a protein-coding gene. Diseases associated with FGFBP2 include asthma. GO annotations related to this gene include growth factor binding.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000004.11 NC_018915.2 NT_006316.17

Regulatory elements:

Regulatory transcription factor binding sites in the FGFBP2 gene promoter:
HFH-3 TBP AP-1 POU3F1 CUTL1 FOXI1 SRY TFIID Msx-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGFBP2 promoter sequence

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Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGFBP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16 Ensembl cytogenetic band: 4p15.32 HGNC cytogenetic band: 4p15.32

FGFBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGFBP2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M015961: view genomic region (about GC identifiers)

Start:	15,961,863 bp from pter	End:	15,970,932 bp from pter
Size:	9,070 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
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About This Section

UniProtKB/Swiss-Prot: FGFP2_HUMAN, Q9BYJ0 (See protein sequence)

Recommended Name: Fibroblast growth factor-binding protein 2 precursor

Size: 223 amino acids; 24581 Da

Explore the universe of human proteins at neXtProt for FGFBP2: NX_Q9BYJ0

Explore proteomics data for FGFBP2 at MOPED

Post-translational modifications:

Glycosylation² at Ser136, Thr147, Ser149, Thr155, Thr159, Thr162

Modification sites at PhosphoSitePlus

See FGFBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_114156.1

ENSEMBL proteins:

ENSP00000259989

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

1 InterPro protein domain:

IPR010510 FGF1-bd

Graphical View of Domain Structure for InterPro Entry Q9BYJ0

ProtoNet protein and cluster: Q9BYJ0

UniProtKB/Swiss-Prot: FGFP2_HUMAN, Q9BYJ0

Similarity: Belongs to the fibroblast growth factor-binding protein family

Find genes that share domains with FGFBP2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019838	growth factor binding	IEA	--

Find genes that share ontologies with FGFBP2 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for FGFBP2:

Increased gamma-H2AX phosphory

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

FGFP2_HUMAN, Q9BYJ0: Secreted, extracellular space

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
cytosol	1
nucleus	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--

Find genes that share ontologies with FGFBP2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

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Search GeneGlobe Interaction Network for FGFBP2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for FGFBP2 gene:

NM_031950.3

Unigene Cluster for FGFBP2:

Fibroblast growth factor binding protein 2

Hs.98785 [show with all ESTs]

Unigene Representative Sequence: BC025720

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000259989(uc003gon.3) ENST00000509331

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Additional mRNA sequence:

AB021123.1 AF361936.1 AY358978.1 BC025720.1

1 DOTS entry:

DT.308036

Selected AceView cDNA sequences (see all 45):

BQ180944 AA563708 BX114768 CA414991 CN479752 CN480296 CA414643 BQ182139

CA413088 BQ183638 BE467511 CA412319 BQ574104 BQ005954 BQ183866 CN480307

BU728487 CA413767 BU617864 AI770009 BQ183143 AA433906 AB021123 CD517420

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FGFBP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATTTCCAGT

About this image

FGFBP2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Bone (Muscoskeletal System) fully expand to see all 5 entries
HyStem+TGFbeta3+GDF5-induced SK11 cells

Cartilage (Muscoskeletal System) fully expand to see all 5 entries
HyStem+TGFbeta3+GDF5-induced SK11 cells

Neural Crest (Gastrulation Derivatives)
PureStem MEL2, NCr-fac Progenitor

Blood (Hematopoietic System)
Natural Killer Cells Peripheral Blood

FGFBP2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

FGFBP2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.98785

UniProtKB/Swiss-Prot: FGFP2_HUMAN, Q9BYJ0

Tissue specificity: Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes

and monocytes (at protein level)

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FGFBP2 gene from Selected species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
oppossum (Monodelphis domestica)	Mammalia	FGFBP2⁶	fibroblast growth factor binding protein 2	46(a)	1 ↔ 1	5(213532001-213532672)
chicken (Gallus gallus)	Aves	FGFBP2¹	fibroblast growth factor binding protein 2	54.75(n) 43(a)		395094 NM_204447.1 NP_989778.1
lizard (Anolis carolinensis)	Reptilia	FGFBP2⁶	fibroblast growth factor binding protein 2	40(a)	1 ↔ 1	4(123927581-123928246)
tropical clawed frog (Xenopus tropicalis)	Amphibia	fgfbp2¹	fibroblast growth factor binding protein 2	47.97(n) 36.51(a)		100491846 XM_002938639.2 XP_002938685.1
zebrafish (Danio rerio)	Actinopterygii	fgfbp2b¹	fibroblast growth factor binding protein 2b	49.75(n) 34.17(a)		100037374 NM_001089526.1 NP_001082995.1

ENSEMBL Gene Tree for FGFBP2 (if available)
TreeFam Gene Tree for FGFBP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147112355^1,2		--	15961483(+)	`AGGATA/GGACCC`	1	--	ds500¹		0	--	--	--	--
rs192919211^1,2		--	15961520(+)	`GGAGAA/GGGAAA`	1	--	ds500¹		0	--	--	--	--
rs4698431^1,2	C,F,H	--	15961555(+)	`TCCATG/ATGAAG`	1	--	ds500¹		26		NS EA NA WA CSA	2494
rs138569514^1,2		--	15961689(+)	`CTTTGA/GTGACA`	1	--	ds500¹		0	--	--	--	--
rs184144061^1,2		--	15961718(+)	`CTCCAA/TCACTG`	1	--	ds500¹		0	--	--	--	--
rs28544486^1,2	C,F	--	15961874(+)	`TTCTGA/CAATCA`	1	--	ut3¹ ese³		1		WA	118
rs189427472^1,2		--	15961914(+)	`ATTTAC/TTGAAC`	1	--	ut3¹		0	--	--	--	--
rs74733021^1,2	C,F	--	15961965(+)	`AGAAGG/TCTCAG`	1	--	ut3¹		1		WA	118
rs117535467^1,2	C,F	--	15961969(+)	`GGCTCA/GGATCA`	1	--	ut3¹		1		EA	120
rs181073650^1,2		--	15962025(+)	`CACTCC/TTGGGC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FGFBP2 (15961863 - 15970932 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for FGFBP2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv527861	CNV	Gain	19592680

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 607713 OMIM disorders: --

1 disease for FGFBP2:
About MalaCards

asthma

Find genes that share disorders with FGFBP2 About GenesLikeMe

Export disorders for FGFBP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FGFBP2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with FGFBP2)

Utopia: connect your pdf to the dynamic
world of online information

A novel serum protein that is selectively produced by cytotoxic lymphocytes. (PubMed id 11342666)^{1, 2, 3} Ogawa K.... Nagata K. (J. Immunol. 2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (Genome Res. 2003)
Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy. (PubMed id 12322897)^{1, 3} Hayano C....Aso T. (Am. J. Reprod. Immunol. 2002)
Generalization of Variants Identified by Genome-Wide Association Studies for Electrocardiographic Traits in African Americans. (PubMed id 23534349)¹ Jeff J.M....Crawford D.C. (Ann. Hum. Genet. 2013)
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas. (PubMed id 21079801)¹ Elgaaen B.V....Gautvik K.M. (PLoS ONE 2010)
Identification of expressed genes characterizing long-term survival in malignant glioma patients. (PubMed id 16652150)¹ Yamanaka R....Nishio K. (Oncogene 2006)
Increase in killer-specific secretory protein of 37 kDa in bronchoalveolar lavage fluid of allergen-challenged patients with atopic asthma. (PubMed id 15898988)¹ Kuepper M....Virchow J.C. (Clin. Exp. Allergy 2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83888	HGNC: 29451	AceView: KSP37	Ensembl:ENSG00000137441	euGenes: HUgn83888
ECgene: FGFBP2	H-InvDB: FGFBP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FGFBP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FGFBP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FGFBP2 gene:
Search GeneIP for patents involving FGFBP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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FGFBP2 Gene

Fibroblast Growth Factor Binding Protein 2

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Export list of displayed genes

FGFBP2 Gene

Fibroblast Growth Factor Binding Protein 2

Aliasesfor FGFBP2 gene

Summariesfor FGFBP2 gene

Genomic Viewsfor FGFBP2 gene

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FGFBP2 Human Recombinant Protein Products:

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Genome Databases showing FGFBP2 gene

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for FGFBP2 gene

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for FGFBP2 gene

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for FGFBP2 gene

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for FGFBP2 gene

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for FGFBP2 gene

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for FGFBP2 gene

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