Aliases for FGFBP2 Gene
Aliases for FGFBP2 Gene
External Ids for FGFBP2 Gene
- HGNC: 29451
- Entrez Gene: 83888
- Ensembl: ENSG00000137441
- OMIM: 607713
- UniProtKB: Q9BYJ0
Previous GeneCards Identifiers for FGFBP2 Gene
- GC04M015571
- GC04M015311
Summaries for FGFBP2 Gene
-
This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008]
GeneCards Summary for FGFBP2 Gene
FGFBP2 (Fibroblast Growth Factor Binding Protein 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR2 and Signaling by GPCR. GO annotations related to this gene include growth factor binding.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFBP2 Gene
Genomics for FGFBP2 Gene
Regulatory Elements for FGFBP2 Gene
Enhancers for FGFBP2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH04G015904 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 15.8 | +62.9 | 62877 | 4.0 | BCOR GTF2F1 CTCF KLF1 FOXA2 JUN SREBF2 MAX ZMYM3 SIN3A | FGFBP1 FGFBP2 PROM1 CD38 FBXL5 BST1 HPRT1P1 |
| GH04G015960 | 1 | Ensembl ENCODE | 24.7 | +6.9 | 6905 | 2.9 | CTCF ESRRA RAD21 SMC3 RELB IKZF2 CHD2 MTA2 NR2F1 BHLHE40 | FGFBP2 GC04M015932 |
| GH04G015920 | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 11.1 | +48.0 | 48016 | 2.2 | NFIB JUN INSM2 FOSL1 GATA2 RCOR1 FOSL2 FOS MAFK ZNF10 | FGFBP2 PROM1 FGFBP1 HPRT1P1 |
| GH04G015808 | 1.1 | FANTOM5 Ensembl | 11.8 | +160.1 | 160109 | 1.2 | HDGF BACH1 BMI1 RELA ARID3A RELB IKZF2 MTA2 NR2F1 BHLHE40 | CD38 FGFBP2 PROM1 BST1 GC04P015792 PIR31595 |
| GH04G016001 | 1 | Ensembl ENCODE | 11.8 | -32.3 | -32291 | 0.6 | CTCF WRNIP1 TEAD4 MAX RAD21 RELA TEAD3 POLR2A ZNF143 SMC3 | FGFBP2 PROM1 BST1 GC04M016016 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FGFBP2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FGFBP2 Gene
- Chromosome:
- 4
- Start:
- 15,960,240 bp from pter
- End:
- 15,969,309 bp from pter
- Size:
- 9,070 bases
- Orientation:
- Minus strand
Genomic View for FGFBP2 Gene
Genes around FGFBP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p15.32 by Ensembl
- 4p15.32 by Entrez Gene
- 4p15.32 by HGNC
FGFBP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGFBP2 Gene
Proteins for FGFBP2 Gene
-
Protein details for FGFBP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BYJ0-FGFP2_HUMAN
- Recommended name:
- Fibroblast growth factor-binding protein 2
- Protein Accession:
- Q9BYJ0
Protein attributes for FGFBP2 Gene
- Size:
- 223 amino acids
- Molecular mass:
- 24581 Da
- Quaternary structure:
- No Data Available
Protein Expression for FGFBP2 Gene
Post-translational modifications for FGFBP2 Gene
Other Protein References for FGFBP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FGFBP2 (FGFBP2)
- Novus Biologicals Antibodies for FGFBP2
-
Abcam antibodies for FGFBP2
- Invitrogen Antibodies for FGFBP2
- antibodies-online Antibodies for FGFBP2: See all 24
- Search GeneTex for Antibodies for FGFBP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGFBP2
Protein Products
-
OriGene Purified Proteins for FGFBP2
- Search Origene for MassSpec and Protein Over-expression Lysates for FGFBP2
- Origene Custom Protein Services for FGFBP2
- antibodies-online Proteins for FGFBP2: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FGFBP2
-
Abcam proteins for FGFBP2
Assay Products
- antibodies-online Kits for FGFBP2: See all 20
No data available for DME Specific Peptides for FGFBP2 Gene
Domains & Families for FGFBP2 Gene
Suggested Antigen Peptide Sequences for FGFBP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BYJ0- Family:
-
- Belongs to the fibroblast growth factor-binding protein family.
No data available for Gene Families for FGFBP2 Gene
Function for FGFBP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019838 | growth factor binding | IEA | -- |
Phenotypes for FGFBP2 Gene
- GenomeRNAi human phenotypes for FGFBP2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FGFBP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
- Search ViGene Biosciences for FGFBP2
CRISPR Products
-
OriGene CRISPR knockouts for FGFBP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGFBP2
- GenScript: Design CRISPR guide RNA sequences for FGFBP2
miRNA Products
- Search ViGene Biosciences for FGFBP2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FGFBP2
- Browse OriGene Inhibitory RNA Products For FGFBP2
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
Clone Products
-
OriGene ORF clones in human for FGFBP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGFBP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FGFBP2
-
ViGene Biosciences adenoviral particle packaged cDNA for FGFBP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FGFBP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FGFBP2 Gene
Localization for FGFBP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGFBP2 Gene
- Secreted, extracellular space.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IEA | -- |
Pathways & Interactions for FGFBP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by FGFR2 | ||
| 2 | Signaling by GPCR | ||
Pathways by source for FGFBP2 Gene
5 Reactome pathways for FGFBP2 Gene
Interacting Proteins for FGFBP2 Gene
No data available for SIGNOR curated interactions for FGFBP2 Gene
Transcripts for FGFBP2 Gene
mRNA/cDNA for FGFBP2 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (45) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGFBP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FGFBP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGFBP2
- GenScript: Design CRISPR guide RNA sequences for FGFBP2
miRNA Products
- Search ViGene Biosciences for FGFBP2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FGFBP2
- Browse OriGene Inhibitory RNA Products For FGFBP2
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
Clone Products
-
OriGene ORF clones in human for FGFBP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGFBP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FGFBP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
- Neural Crest (Gastrulation Derivatives)
mRNA differential expression in normal tissues according to GTEx for FGFBP2 Gene
This gene is overexpressed in Whole Blood (x15.6) and Nerve - Tibial (x13.0).
This gene is overexpressed in Synovial fluid (52.5) and Monocytes (12.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGFBP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGFBP2 Gene:
FGFBP2SOURCE GeneReport for Unigene cluster for FGFBP2 Gene:
Hs.98785mRNA Expression by UniProt/SwissProt for FGFBP2 Gene:
Q9BYJ0-FGFP2_HUMAN
Tissue specificity:
Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at protein level).
Evidence on tissue expression from TISSUES for FGFBP2 Gene
- Blood(4.3)
- Pancreas(4.2)
Primer Products
-
OriGene qPCR primer pairs for FGFBP2
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFBP2 Gene
Orthologs for FGFBP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGFBP2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FGFBP2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGFBP2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FGFBP2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgfbp2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgfbp2b 34 35 |
|
||
| fgfbp2a 35 |
|
OneToMany |
- Species where no ortholog for FGFBP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGFBP2 Gene
No data available for Paralogs for FGFBP2 Gene
Variants for FGFBP2 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000592455 | -- | 15,961,938(+) | GAGAA(C/T)AAGAC | intron-variant | |
| rs1001061171 | -- | 15,961,588(+) | TAATA(G/T)GAAAA | intron-variant | |
| rs1001247347 | -- | 15,965,186(+) | GGAGG(A/C)AGTGG | upstream-variant-2KB | |
| rs1001513821 | -- | 15,959,854(+) | TTGAT(G/T)AGGAT | downstream-variant-500B | |
| rs1001866543 | -- | 15,961,037(+) | TATGG(C/T)AGCCC | intron-variant |
Residual Variation Intolerance Score:
85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.11;
80.52% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FGFBP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FGFBP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP2 Gene
Disorders for FGFBP2 Gene
Relevant External Links for FGFBP2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FGFBP2
No disorders were found for FGFBP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGFBP2 Gene
Publications for FGFBP2 Gene
- A novel serum protein that is selectively produced by cytotoxic lymphocytes. (PMID: 11342666) Ogawa K. … Nagata K. (J. Immunol. 2001) 2 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
- Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy. (PMID: 12322897) Hayano C. … Aso T. (Am. J. Reprod. Immunol. 2002) 2 3 64
- Killer-specific secretory (Ksp37) gene expression in subjects with Down's syndrome. (PMID: 27032399) Salemi M. … Romano C. (Neurol. Sci. 2016) 3 64
Products for FGFBP2 Gene
- R&D Systems Antibodies for FGFBP2 (FGFBP2)
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- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- OriGene Purified Proteins for FGFBP2
- Search Origene for MassSpec and Protein Over-expression Lysates for FGFBP2
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FGFBP2
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- OriGene qPCR primer pairs for FGFBP2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for FGFBP2 in any vector
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- GenScript Custom overexpressing Cell Line Services for FGFBP2
- GenScript: Design CRISPR guide RNA sequences for FGFBP2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Plasmid Preparation
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- Novus Biologicals Antibodies for FGFBP2
- Novus Biologicals proteins and lysates for FGFBP2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FGFBP2
- Abcam proteins for FGFBP2
- Search for Assays for FGFBP2 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- antibodies-online Antibodies for FGFBP2: See all 24
- antibodies-online Kits for FGFBP2: See all 20
- antibodies-online Proteins for FGFBP2: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for FGFBP2
- Search GeneTex for Proteins for FGFBP2
- ViGene Biosciences adenoviral particle packaged cDNA for FGFBP2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FGFBP2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
- Search ViGene Biosciences for FGFBP2
- Santa Cruz Biotechnology (SCBT) Antibodies for FGFBP2
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- Santa Cruz Biotechnology (SCBT) CRISPR for FGFBP2
- Horizon Cell Lines for FGFBP2
- Cyagen custom Knockout/knockin (KOKI) mouse models for FGFBP2
- VectorBuilder custom plasmid, inducible vectors for FGFBP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FGFBP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FGFBP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
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- (88) miRTarBase
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- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
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- (141) ENCODE
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- (143) Horizon
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer