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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FGFBP2 Gene

protein-coding GIFtS: 41
GCID: GC04M015961

fibroblast growth factor binding protein 2

Explore 4 diseases affiliated with
FGFBP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fibroblast Growth Factor Binding Protein 2¹ ²		FGF-Binding Protein 2² ³
KSP37¹ ² ³ ⁵		HBp17-Related Protein² ³
37 KDa Killer-Specific Secretory Protein² ³		HBP17RP²
FGF-BP2² ³		Fibroblast Growth Factor-Binding Protein 2²
FGFBP-2² ³		Killer-Specific Secretory Protein Of 37 KDa²
HBp17-RP² ³		Ksp37³

External Ids:	HGNC: 29451¹	Entrez Gene: 83888²	Ensembl: ENSG00000137441⁷	OMIM: 607713⁵	UniProtKB: Q9BYJ0³

Export aliases for FGFBP2 gene to outside databases

Previous GC identifers: GC04M015571 GC04M015311

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGFBP2:

This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum

protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated

immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic

asthma.(provided by RefSeq Staff, Oct 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_006316.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FGFBP2 gene promoter:
HFH-3 TBP AP-1 POU3F1 CUTL1 FOXI1 SRY TFIID Msx-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGFBP2 promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGFBP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16 Ensembl cytogenetic band: 4p15.32 HGNC cytogenetic band: 4p15.32

FGFBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGFBP2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M015961: view genomic region (about GC identifiers)

Start:	15,961,863 bp from pter	End:	15,970,932 bp from pter
Size:	9,070 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FGFP2_HUMAN, Q9BYJ0 (See protein sequence)

Recommended Name: Fibroblast growth factor-binding protein 2 precursor

Size: 223 amino acids; 24581 Da

Subcellular location: Secreted, extracellular space

Explore the universe of human proteins at neXtProt for FGFBP2: NX_Q9BYJ0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BYJ0

FGFBP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_114156.1

ENSEMBL proteins:

ENSP00000259989

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--

FGFBP2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FGFBP2 for domains About GeneDecksing

1 InterPro domain/family:

IPR010510 FGF1-bd

Graphical View of Domain Structure for InterPro Entry Q9BYJ0

ProtoNet protein and cluster: Q9BYJ0

UniProtKB/Swiss-Prot: FGFP2_HUMAN, Q9BYJ0

Similarity: Belongs to the fibroblast growth factor-binding protein family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019838	growth factor binding	IEA	--

FGFBP2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for FGFBP2:

Increased gamma-H2AX phosphory

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FGFBP2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about FGFBP2 / FGFP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for FGFBP2 gene:

NM_031950.3

Unigene Cluster for FGFBP2:

Fibroblast growth factor binding protein 2

Hs.98785 [show with all ESTs]

Unigene Representative Sequence: BC025720

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000259989(uc003gon.3) ENST00000509331

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Additional cDNA sequence:

AB021123.1 AF361936.1 AY358978.1 BC025720.1

1 DOTS entry:

DT.308036

24/45 AceView cDNA sequences (see all 45):

CA412319 BQ574104 AA563708 BE467511 AI770009 CA413088 BQ183143 BU617864

BQ183866 CA414991 CN479752 BX114768 BU728487 BQ183638 CN480307 CA414643

CA413767 BQ005954 CN480296 BQ180944 BQ182139 BQ028397 AB021123 BI910384

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FGFBP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTTCCAGT

About this image

FGFBP2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+BMP4-induced 4D20.8 cells (Chondrogenic inducti...)

Bone, Cartilage

TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)

HyStem+TGF?3+GDF5-induced 4D20.8 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FGFBP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGFBP2

SOURCE GeneReport for Unigene cluster: Hs.98785

UniProtKB/Swiss-Prot: FGFP2_HUMAN, Q9BYJ0

Tissue specificity: Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and

monocytes (at protein level)

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FGFBP2 gene from 3/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FGFBP2¹	fibroblast growth factor binding protein 2	54.59(n) 43(a)		395094 NM_204447.1 NP_989778.1
lizard (Anolis carolinensis)	Reptilia	FGFBP2⁶	--	39(a)	1 ↔ 1	4(123927581-123928246)
zebrafish (Danio rerio)	Actinopterygii	fgfbp2¹	fibroblast growth factor binding protein 2	47.96(n) 34.44(a)		793049 XM_001332686.3 XP_001332722.1

ENSEMBL Gene Tree for FGFBP2 (if available)
TreeFam Gene Tree for FGFBP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FGFBP2 gene

FGFBP1²

FGFBP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147112355^1,2		--	15961483(+)	`AGGATA/GGACCC`	1	--	ds500¹		0	--	--	--	--
rs192919211^1,2		--	15961520(+)	`GGAGAA/GGGAAA`	1	--	ds500¹		0	--	--	--	--
rs4698431^1,2	C,F,H	--	15961555(+)	`TCCATG/ATGAAG`	1	--	ds500¹		26		NS EA NA WA CSA	2494
rs138569514^1,2		--	15961689(+)	`CTTTGA/GTGACA`	1	--	ds500¹		0	--	--	--	--
rs184144061^1,2		--	15961718(+)	`CTCCAA/TCACTG`	1	--	ds500¹		0	--	--	--	--
rs28544486^1,2	C,F	--	15961874(+)	`TTCTGA/CAATCA`	1	--	ut3¹ ese³		1		WA	118
rs189427472^1,2		--	15961914(+)	`ATTTAC/TTGAAC`	1	--	ut3¹		0	--	--	--	--
rs74733021^1,2	F	--	15961965(+)	`AGAAGG/TCTCAG`	1	--	ut3¹		1		WA	118
rs117535467^1,2	C,F	--	15961969(+)	`GGCTCA/GGATCA`	1	--	ut3¹		1		EA	120
rs181073650^1,2		--	15962025(+)	`CACTCC/TTGGGC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FGFBP2 (15961863 - 15970932 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FGFBP2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FGFBP2 for disorders           About GeneDecksing

OMIM gene information: 607713    OMIM disorders: --

4 diseases for FGFBP2:    About MalaCards

asthma malignant glioma ovarian carcinoma carcinoma

Export disorders for FGFBP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FGFBP2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FGFBP2)

Utopia: connect your pdf to the dynamic
world of online information

A novel serum protein that is selectively produced by cytotoxic lymphocytes. (PubMed id 11342666)^{1, 2, 3} Ogawa K.... Nagata K. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy. (PubMed id 12322897)^{1, 3} Hayano C....Aso T. (2002)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
POLD2 and KSP37 (FGFBP2) correlate strongly with hist ology, stage and outcome in ovarian carcinomas. (PubMed id 21079801)¹ Elgaaen B.V....Gautvik K.M. (2010)
Identification of expressed genes characterizing long-term survival in malignant glioma patients. (PubMed id 16652150)¹ Yamanaka R....Nishio K. (2006)
Increase in killer-specific secretory protein of 37 kDa in bronchoalveolar lavage fluid of allergen-challenged patients with atopic asthma. (PubMed id 15898988)¹ Kuepper M....Virchow J.C. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83888	HGNC: 29451	AceView: KSP37	Ensembl:ENSG00000137441	euGenes: HUgn83888
ECgene: FGFBP2	H-InvDB: FGFBP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FGFBP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FGFBP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FGFBP2 gene:
Search GeneIP for patents involving FGFBP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FGFBP2
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	GenScript Custom Purified and Recombinant Proteins Services for FGFBP2		GenScript cDNA clones with any tag delivered in your preferred vector for FGFBP2
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	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in FGFBP2 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGFBP2

	SwitchGear 3'UTR luciferase reporter plasmids for FGFBP2
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Search ThermoFisher Antibodies for FGFBP2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGFBP2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FGFBP2

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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FGFBP2 Gene

fibroblast growth factor binding protein 2

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FGFBP2 Gene

fibroblast growth factor binding protein 2

Aliasesfor FGFBP2 gene

Summariesfor FGFBP2 gene

Genomic Viewsfor FGFBP2 gene

Proteinsfor FGFBP2 gene

Protein Domains /Familiesfor FGFBP2 gene

Functionfor FGFBP2 gene

Pathways & Interactionsfor FGFBP2 gene

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Genome Databases showing FGFBP2 gene

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Specialized Databases showing FGFBP2 gene

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for FGFBP2 gene

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for FGFBP2 gene

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for FGFBP2 gene

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for FGFBP2 gene

Function
for FGFBP2 gene

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for FGFBP2 gene

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for FGFBP2 gene

Transcripts
for FGFBP2 gene

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for FGFBP2 gene

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