Aliases for FGFBP2 Gene
Aliases for FGFBP2 Gene
External Ids for FGFBP2 Gene
- HGNC: 29451
- Entrez Gene: 83888
- Ensembl: ENSG00000137441
- OMIM: 607713
- UniProtKB: Q9BYJ0
Previous GeneCards Identifiers for FGFBP2 Gene
- GC04M015571
- GC04M015311
Summaries for FGFBP2 Gene
-
This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008]
GeneCards Summary for FGFBP2 Gene
FGFBP2 (Fibroblast Growth Factor Binding Protein 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR2 and Signaling by GPCR. GO annotations related to this gene include growth factor binding.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFBP2 Gene
Genomics for FGFBP2 Gene
Regulatory Elements for FGFBP2 Gene
Enhancers for FGFBP2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH04F015960 | 0.9 | Ensembl ENCODE | 24.7 | +6.6 | 6634 | 3.4 | CTCF MTA2 NR2F1 USF2 TBX21 RAD21 EP300 RAD51 IKZF1 SMC3 | FGFBP2 GC04M015932 |
| GH04F015904 | 1.4 | FANTOM5 Ensembl ENCODE | 15.8 | +62.9 | 62877 | 4.0 | BCOR GTF2F1 CTCF KLF1 SREBF2 JUN MAX ZMYM3 SIN3A YY1 | FGFBP1 FGFBP2 PROM1 CD38 FBXL5 BST1 HPRT1P1 |
| GH04F015920 | 1.3 | FANTOM5 Ensembl ENCODE | 11 | +48.0 | 48016 | 2.2 | JUN CEBPB INSM2 ZEB2 MNT EP300 MAFF JUND STAT3 RCOR1 | FGFBP2 PROM1 FGFBP1 HPRT1P1 |
| GH04F015808 | 1.1 | FANTOM5 Ensembl | 11.8 | +160.4 | 160408 | 1.8 | HDGF MTA2 BMI1 TBX21 EP300 RELA RAD51 IKZF1 TARDBP NBN | CD38 FGFBP2 PROM1 BST1 GC04P015792 PIR31595 |
| GH04F016001 | 1 | Ensembl ENCODE | 11.8 | -32.3 | -32334 | 0.7 | CTCF WRNIP1 TEAD4 MAX RAD21 TEAD3 RELA POLR2A ZNF143 SMC3 | FGFBP2 PROM1 BST1 GC04M016016 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FGFBP2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FGFBP2 Gene
- Chromosome:
- 4
- Start:
- 15,960,240 bp from pter
- End:
- 15,969,309 bp from pter
- Size:
- 9,070 bases
- Orientation:
- Minus strand
Genomic View for FGFBP2 Gene
Genes around FGFBP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p15.32 by Ensembl
- 4p15.32 by Entrez Gene
- 4p15.32 by HGNC
FGFBP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGFBP2 Gene
Proteins for FGFBP2 Gene
-
Protein details for FGFBP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BYJ0-FGFP2_HUMAN
- Recommended name:
- Fibroblast growth factor-binding protein 2
- Protein Accession:
- Q9BYJ0
Protein attributes for FGFBP2 Gene
- Size:
- 223 amino acids
- Molecular mass:
- 24581 Da
- Quaternary structure:
- No Data Available
Protein Expression for FGFBP2 Gene
Post-translational modifications for FGFBP2 Gene
Other Protein References for FGFBP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FGFBP2
-
Abcam antibodies for FGFBP2
- Invitrogen Antibodies for FGFBP2
- antibodies-online Antibodies for FGFBP2: See all 24
- Search GeneTex for Antibodies for FGFBP2
-
St John's Laboratory Antibodies for FGFBP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGFBP2
Protein Products
-
OriGene Purified Proteins for FGFBP2
- Search Origene for MassSpec and Protein Over-expression Lysates for FGFBP2
- Origene Custom Protein Services for FGFBP2
- antibodies-online Proteins for FGFBP2: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FGFBP2
-
Abcam proteins for FGFBP2
Assay Products
- antibodies-online Kits for FGFBP2: See all 20
No data available for DME Specific Peptides for FGFBP2 Gene
Domains & Families for FGFBP2 Gene
Suggested Antigen Peptide Sequences for FGFBP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BYJ0- Family:
-
- Belongs to the fibroblast growth factor-binding protein family.
No data available for Gene Families for FGFBP2 Gene
Function for FGFBP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019838 | growth factor binding | IEA | -- |
Phenotypes for FGFBP2 Gene
- GenomeRNAi human phenotypes for FGFBP2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FGFBP2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for FGFBP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
- Search ViGene Biosciences for FGFBP2
CRISPR Products
-
OriGene CRISPR knockouts for FGFBP2
- GenScript: Design CRISPR guide RNA sequences for FGFBP2
miRNA Products
- Search ViGene Biosciences for FGFBP2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FGFBP2
- Browse OriGene Inhibitory RNA Products For FGFBP2
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
Clone Products
-
OriGene ORF clones in human for FGFBP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGFBP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FGFBP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FGFBP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for FGFBP2
-
ViGene Biosciences adenoviral particle packaged cDNA for FGFBP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FGFBP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FGFBP2 Gene
Localization for FGFBP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGFBP2 Gene
- Secreted, extracellular space.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IEA | -- |
Pathways & Interactions for FGFBP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by FGFR2 | ||
| 2 | Signaling by GPCR | ||
Pathways by source for FGFBP2 Gene
5 Reactome pathways for FGFBP2 Gene
Interacting Proteins for FGFBP2 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| APP |
No data available for SIGNOR curated interactions for FGFBP2 Gene
Transcripts for FGFBP2 Gene
mRNA/cDNA for FGFBP2 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (45) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGFBP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FGFBP2
- GenScript: Design CRISPR guide RNA sequences for FGFBP2
miRNA Products
- Search ViGene Biosciences for FGFBP2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FGFBP2
- Browse OriGene Inhibitory RNA Products For FGFBP2
-
ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
Clone Products
-
OriGene ORF clones in human for FGFBP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGFBP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FGFBP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FGFBP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for FGFBP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
- Neural Crest (Gastrulation Derivatives)
mRNA differential expression in normal tissues according to GTEx for FGFBP2 Gene
This gene is overexpressed in Whole Blood (x15.6) and Nerve - Tibial (x13.0).
This gene is overexpressed in Synovial fluid (52.5) and Monocytes (12.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGFBP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGFBP2 Gene:
FGFBP2SOURCE GeneReport for Unigene cluster for FGFBP2 Gene:
Hs.98785mRNA Expression by UniProt/SwissProt for FGFBP2 Gene:
Q9BYJ0-FGFP2_HUMAN
Tissue specificity:
Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at protein level).
Primer Products
-
OriGene qPCR primer pairs for FGFBP2
No data available for Protein tissue co-expression partners for FGFBP2 Gene
Orthologs for FGFBP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGFBP2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FGFBP2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGFBP2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FGFBP2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgfbp2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgfbp2b 34 35 |
|
||
| fgfbp2a 35 |
|
OneToMany |
- Species where no ortholog for FGFBP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGFBP2 Gene
No data available for Paralogs for FGFBP2 Gene
Variants for FGFBP2 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs111244757 | -- | 15,962,878(+) | GCAGC(-/G)AAAGC | reference, frameshift-variant | |
| rs111310331 | -- | 15,965,124(+) | GCTTC(C/T)TGTAA | upstream-variant-2KB | |
| rs111611403 | -- | 15,963,891(+) | ATGAC(A/G)AGGAA | upstream-variant-2KB | |
| rs111707241 | -- | 15,962,734(+) | TTGAG(A/G)CTGGA | reference, synonymous-codon | |
| rs111774227 | -- | 15,964,666(+) | TTAAA(A/G)TTTTT | upstream-variant-2KB |
Residual Variation Intolerance Score:
85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.11;
80.52% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FGFBP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FGFBP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP2 Gene
Disorders for FGFBP2 Gene
Relevant External Links for FGFBP2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FGFBP2
No disorders were found for FGFBP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGFBP2 Gene
Publications for FGFBP2 Gene
- A novel serum protein that is selectively produced by cytotoxic lymphocytes. (PMID: 11342666) Ogawa K. … Nagata K. (J. Immunol. 2001) 2 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
- Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy. (PMID: 12322897) Hayano C. … Aso T. (Am. J. Reprod. Immunol. 2002) 2 3 64
- CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3 64
Products for FGFBP2 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for FGFBP2
- Search Origene for MassSpec and Protein Over-expression Lysates for FGFBP2
- Origene Custom Protein Services for FGFBP2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FGFBP2
- Browse OriGene Inhibitory RNA Products For FGFBP2
- OriGene qPCR primer pairs for FGFBP2
- OriGene CRISPR knockouts for FGFBP2
- OriGene ORF clones in human for FGFBP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Design CRISPR guide RNA sequences for FGFBP2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Sino Biological Human cDNA Clone for FGFBP2
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- Novus Biologicals Antibodies for FGFBP2
- Novus Biologicals proteins and lysates for FGFBP2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FGFBP2
- Abcam proteins for FGFBP2
- Search for Assays for FGFBP2 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- antibodies-online Antibodies for FGFBP2: See all 24
- antibodies-online Kits for FGFBP2: See all 20
- antibodies-online Proteins for FGFBP2: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for FGFBP2
- Search GeneTex for Proteins for FGFBP2
- ViGene Biosciences adenoviral particle packaged cDNA for FGFBP2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FGFBP2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FGFBP2 gene
- Search ViGene Biosciences for FGFBP2
- Santa Cruz Biotechnology (SCBT) Antibodies for FGFBP2
- Search Santa Cruz Biotechnology (SCBT) for FGFBP2 siRNA/shRNA
- Browse Santa Cruz Biotechnology (SCBT) for FGFBP2 CRISPR
- Horizon Cell Lines for FGFBP2
- Cyagen custom Knockout/knockin (KOKI) mouse models for FGFBP2
- VectorBuilder custom plasmid, inducible vectors for FGFBP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FGFBP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FGFBP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (141) ENCODE
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- (146) Cyagen
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- (148) SNPedia
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