Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FGFBP2 Gene

Aliases for FGFBP2 Gene

  • Fibroblast Growth Factor Binding Protein 2 2 3 5
  • Killer-Specific Secretory Protein Of 37 KDa 2 3
  • 37 KDa Killer-Specific Secretory Protein 3 4
  • FGF-Binding Protein 2 3 4
  • HBp17-Related Protein 3 4
  • HBp17-RP 3 4
  • FGF-BP2 3 4
  • FGFBP-2 3 4
  • KSP37 3 4
  • Fibroblast Growth Factor-Binding Protein 2 3
  • HBP17RP 3

External Ids for FGFBP2 Gene

Previous GeneCards Identifiers for FGFBP2 Gene

  • GC04M015571
  • GC04M015311

Summaries for FGFBP2 Gene

Entrez Gene Summary for FGFBP2 Gene

  • This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008]

GeneCards Summary for FGFBP2 Gene

FGFBP2 (Fibroblast Growth Factor Binding Protein 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR2 and Signaling by GPCR. GO annotations related to this gene include growth factor binding.

Additional gene information for FGFBP2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFBP2 Gene

Genomics for FGFBP2 Gene

Regulatory Elements for FGFBP2 Gene

Enhancers for FGFBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H015904 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.8 +62.9 62877 3 BCOR GTF2F1 CTCF KLF1 FOXA2 JUN MAX ZMYM3 RFX5 E2F1 FGFBP1 FGFBP2 PROM1 CD38 FBXL5 BST1 HPRT1P1
GH04H015960 0.9 Ensembl ENCODE 24.7 +6.9 6905 2 CTCF ESRRA DPF2 RAD21 IKZF1 SMC3 ZBTB33 ATF7 IKZF2 SPI1 FGFBP2 GC04M015932
GH04H015920 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +48.0 48016 2 NFIB JUN INSM2 FOSL1 POLR2A RCOR1 FOSL2 FOS MAFK ZNF10 FGFBP2 PROM1 FGFBP1 HPRT1P1
GH04H015808 1.1 FANTOM5 Ensembl 11.8 +160.1 160109 1 HDGF TBL1XR1 BACH1 BMI1 BATF RELA ATF7 RUNX3 IKZF2 CHD2 CD38 FGFBP2 PROM1 BST1 GC04P015792 PIR31595
GH04H016001 1 Ensembl ENCODE 11.8 -32.3 -32291 0 CTCF RB1 MAX RAD21 RELA TEAD3 POLR2A SMC3 ZNF143 PRDM10 FGFBP2 PROM1 BST1 GC04M016016
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGFBP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FGFBP2 Gene

Chromosome:
4
Start:
15,960,240 bp from pter
End:
15,969,309 bp from pter
Size:
9,070 bases
Orientation:
Minus strand

Genomic View for FGFBP2 Gene

Genes around FGFBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFBP2 Gene

Proteins for FGFBP2 Gene

  • Protein details for FGFBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYJ0-FGFP2_HUMAN
    Recommended name:
    Fibroblast growth factor-binding protein 2
    Protein Accession:
    Q9BYJ0

    Protein attributes for FGFBP2 Gene

    Size:
    223 amino acids
    Molecular mass:
    24581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FGFBP2 Gene

Post-translational modifications for FGFBP2 Gene

  • Glycosylation at posLast=136136, isoforms=159, and posLast=162162
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FGFBP2

No data available for DME Specific Peptides for FGFBP2 Gene

Domains & Families for FGFBP2 Gene

Gene Families for FGFBP2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for FGFBP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FGFBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYJ0

UniProtKB/Swiss-Prot:

FGFP2_HUMAN :
  • Belongs to the fibroblast growth factor-binding protein family.
Family:
  • Belongs to the fibroblast growth factor-binding protein family.
genes like me logo Genes that share domains with FGFBP2: view

Function for FGFBP2 Gene

Phenotypes From GWAS Catalog for FGFBP2 Gene

Gene Ontology (GO) - Molecular Function for FGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019838 growth factor binding IEA --
genes like me logo Genes that share ontologies with FGFBP2: view
genes like me logo Genes that share phenotypes with FGFBP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FGFBP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FGFBP2 Gene

Localization for FGFBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFBP2 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFBP2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for FGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with FGFBP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGFBP2 Gene

Pathways & Interactions for FGFBP2 Gene

genes like me logo Genes that share pathways with FGFBP2: view

Interacting Proteins for FGFBP2 Gene

Gene Ontology (GO) - Biological Process for FGFBP2 Gene

None

No data available for SIGNOR curated interactions for FGFBP2 Gene

Drugs & Compounds for FGFBP2 Gene

No Compound Related Data Available

Transcripts for FGFBP2 Gene

mRNA/cDNA for FGFBP2 Gene

Unigene Clusters for FGFBP2 Gene

Fibroblast growth factor binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FGFBP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FGFBP2 Gene

No ASD Table

Relevant External Links for FGFBP2 Gene

GeneLoc Exon Structure for
FGFBP2
ECgene alternative splicing isoforms for
FGFBP2

Expression for FGFBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGFBP2 Gene

mRNA differential expression in normal tissues according to GTEx for FGFBP2 Gene

This gene is overexpressed in Whole Blood (x15.6) and Nerve - Tibial (x13.0).

Protein differential expression in normal tissues from HIPED for FGFBP2 Gene

This gene is overexpressed in Synovial fluid (52.5) and Monocytes (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGFBP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of FGFBP2 Gene:

FGFBP2

SOURCE GeneReport for Unigene cluster for FGFBP2 Gene:

Hs.98785

mRNA Expression by UniProt/SwissProt for FGFBP2 Gene:

Q9BYJ0-FGFP2_HUMAN
Tissue specificity: Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at protein level).

Evidence on tissue expression from TISSUES for FGFBP2 Gene

  • Blood(4.3)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with FGFBP2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFBP2 Gene

Orthologs for FGFBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGFBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGFBP2 33 34
  • 98.65 (n)
oppossum
(Monodelphis domestica)
Mammalia FGFBP2 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGFBP2 33 34
  • 54.75 (n)
lizard
(Anolis carolinensis)
Reptilia FGFBP2 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfbp2 33
  • 47.97 (n)
zebrafish
(Danio rerio)
Actinopterygii fgfbp2b 33 34
  • 49.75 (n)
fgfbp2a 34
  • 26 (a)
OneToMany
Species where no ortholog for FGFBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGFBP2 Gene

ENSEMBL:
Gene Tree for FGFBP2 (if available)
TreeFam:
Gene Tree for FGFBP2 (if available)

Paralogs for FGFBP2 Gene

No data available for Paralogs for FGFBP2 Gene

Variants for FGFBP2 Gene

Sequence variations from dbSNP and Humsavar for FGFBP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000592455 -- 15,961,938(+) GAGAA(C/T)AAGAC intron-variant
rs1001061171 -- 15,961,588(+) TAATA(G/T)GAAAA intron-variant
rs1001247347 -- 15,965,186(+) GGAGG(A/C)AGTGG upstream-variant-2KB
rs1001513821 -- 15,959,854(+) TTGAT(G/T)AGGAT downstream-variant-500B
rs1001866543 -- 15,961,037(+) TATGG(C/T)AGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGFBP2 Gene

Variant ID Type Subtype PubMed ID
nsv527861 CNV gain 19592680

Variation tolerance for FGFBP2 Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGFBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGFBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP2 Gene

Disorders for FGFBP2 Gene

Relevant External Links for FGFBP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGFBP2

No disorders were found for FGFBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGFBP2 Gene

Publications for FGFBP2 Gene

  1. A novel serum protein that is selectively produced by cytotoxic lymphocytes. (PMID: 11342666) Ogawa K … Nagata K (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  4. Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy. (PMID: 12322897) Hayano C … Aso T (American journal of reproductive immunology (New York, N.Y. : 1989) 2002) 2 3 60
  5. Killer-specific secretory (Ksp37) gene expression in subjects with Down's syndrome. (PMID: 27032399) Salemi M … Romano C (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2016) 3 60

Products for FGFBP2 Gene

Sources for FGFBP2 Gene

Content
Loading form....