FGFBP2 Gene

Aliases
for FGFBP2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC04M015571 GC04M015311

Summaries
for FGFBP2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for FGFBP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000004.11  NC_018915.2  NT_006316.17  

SwitchGear Promoter luciferase reporter plasmid: FGFBP2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGFBP2

FGFBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M015961:  view genomic region     (about GC identifiers)

Proteins
for FGFBP2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for FGFBP2: NX_Q9BYJ0

Explore proteomics data for FGFBP2 at MOPED

Post-translational modifications: 

FGFBP2 Human Recombinant Protein Products:

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	antibodies-online peptides for FGFBP2

FGFBP2 Antibody Products:

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	antibodies-online antibodies for FGFBP2 (19 products)

FGFBP2 Assay Products:

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	antibodies-online kits for FGFBP2 (19 products)

Domains /
Families
for FGFBP2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9BYJ0

Find genes that share domains with FGFBP2           About GenesLikeMe

Function
for FGFBP2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for FGFBP2

miRNA Products:		Block miRNA regulation of human, mouse, rat FGFBP2 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate FGFBP2:
		hsa-miR-875-3p
		SwitchGear 3'UTR luciferase reporter plasmid: FGFBP2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for FGFBP2
		Predesigned siRNA for gene silencing in human, mouse, rat FGFBP2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for FGFBP2

Clone Products:		OriGene clones in human, mouse for FGFBP2 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FGFBP2 (NM_031950)
		Sino Biological Human cDNA Clone for FGFBP2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGFBP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGFBP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FGFBP2
		Browse ESI BIO Cell Lines and PureStem Progenitors for FGFBP2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGFBP2

Localization
for FGFBP2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
cytosol	1
nucleus	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for FGFBP2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for FGFBP2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for FGFBP2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for FGFBP2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FGFBP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATTTCCAGT

About this image

Bone (Muscoskeletal System)    fully expand to see all 5 entries
HyStem+TGFbeta3+GDF5-induced SK11 cells
Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
HyStem+TGFbeta3+GDF5-induced SK11 cells
Neural Crest (Gastrulation Derivatives)
PureStem MEL2, NCr-fac Progenitor
Blood (Hematopoietic System)
Natural Killer Cells Peripheral Blood

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for FGFBP2
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FGFBP2
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		QuantiFast Probe-based Assays in human, mouse, rat FGFBP2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGFBP2

Orthologs
for FGFBP2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for FGFBP2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for FGFBP2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FGFBP2 (see all 180)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1471123551,2		--	15961483(+)	AGGATA/GGACCC	1	--	ds5001		0	--	--	--	--
rs1929192111,2		--	15961520(+)	GGAGAA/GGGAAA	1	--	ds5001		0	--	--	--	--
rs46984311,2	C,F,H	--	15961555(+)	TCCATG/ATGAAG	1	--	ds5001		26		NS EA NA WA CSA	2494
rs1385695141,2		--	15961689(+)	CTTTGA/GTGACA	1	--	ds5001		0	--	--	--	--
rs1841440611,2		--	15961718(+)	CTCCAA/TCACTG	1	--	ds5001		0	--	--	--	--
rs285444861,2	C,F	--	15961874(+)	TTCTGA/CAATCA	1	--	ut31 ese3		1		WA	118
rs1894274721,2		--	15961914(+)	ATTTAC/TTGAAC	1	--	ut31		0	--	--	--	--
rs747330211,2	C,F	--	15961965(+)	AGAAGG/TCTCAG	1	--	ut31		1		WA	118
rs1175354671,2	C,F	--	15961969(+)	GGCTCA/GGATCA	1	--	ut31		1		EA	120
rs1810736501,2		--	15962025(+)	CACTCC/TTGGGC	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for FGFBP2 (15961863 - 15970932 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for FGFBP2:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv527861	CNV	Gain	19592680

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing FGFBP2

DNA2.0 Custom Variant and Variant Library Synthesis for FGFBP2

Disorders / Diseases
for FGFBP2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for FGFBP2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. A novel serum protein that is selectively produced by cytotoxic lymphocytes. (PubMed id 11342666)^{1, 2, 3} Ogawa K.... Nagata K. (J. Immunol. 2001)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (Genome Res. 2003)
4. Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy. (PubMed id 12322897)^{1, 3} Hayano C....Aso T. (Am. J. Reprod. Immunol. 2002)
5. Generalization of Variants Identified by Genome-Wide Association Studies for Electrocardiographic Traits in African Americans. (PubMed id 23534349)¹ Jeff J.M....Crawford D.C. (Ann. Hum. Genet. 2013)
6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
7. POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas. (PubMed id 21079801)¹ Elgaaen B.V....Gautvik K.M. (PLoS ONE 2010)
8. Identification of expressed genes characterizing long-term survival in malignant glioma patients. (PubMed id 16652150)¹ Yamanaka R....Nishio K. (Oncogene 2006)
9. Increase in killer-specific secretory protein of 37 kDa in bronchoalveolar lavage fluid of allergen-challenged patients with atopic asthma. (PubMed id 15898988)¹ Kuepper M....Virchow J.C. (Clin. Exp. Allergy 2005)
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for FGFBP2 gene

Genome Databases showing FGFBP2 gene

Other Databases showing FGFBP2 gene

Specialized Databases showing FGFBP2 gene

Products
for FGFBP2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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