Aliases for FGFBP1 Gene
External Ids for FGFBP1 Gene
Previous GeneCards Identifiers for FGFBP1 Gene
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
GeneCards Summary for FGFBP1 Gene
FGFBP1 (Fibroblast Growth Factor Binding Protein 1) is a Protein Coding gene. Diseases associated with FGFBP1 include Colorectal Adenocarcinoma. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and SHC-mediated cascade-FGFR4. GO annotations related to this gene include heparin binding and fibroblast growth factor binding.
UniProtKB/Swiss-Prot for FGFBP1 Gene
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.