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FGFBP1 Gene

protein-coding   GIFtS: 53
GCID: GC04M015937

Fibroblast Growth Factor Binding Protein 1

  See FGFBP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor Binding Protein 11 2     FGF-BP12 3
FGFBP2 3 5     FGFBP-12 3
HBP172 3 5     FGF-Binding Protein 12 3
17 KDa HBGF-Binding Protein2 3     Fibroblast Growth Factor-Binding Protein 12
17 KDa Heparin-Binding Growth Factor-Binding Protein2 3     Heparin-Binding Growth Factor Binding Protein2
FGF-BP2 3     HBp173

External Ids:    HGNC: 196951   Entrez Gene: 99822   Ensembl: ENSG000001374407   OMIM: 6077375   UniProtKB: Q145123   

Export aliases for FGFBP1 gene to outside databases

Previous GC identifers: GC04M015689 GC04M015613 GC04M015546 GC04M015286


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGFBP1 Gene:
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role
in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating
their biological effects on target cells. The encoded protein may also play a role in tumor growth as an
angiogenic switch molecule, and expression of this gene has been associated with several types of cancer
including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of
chromosome 4. (provided by RefSeq, Nov 2011)

GeneCards Summary for FGFBP1 Gene:
FGFBP1 (fibroblast growth factor binding protein 1) is a protein-coding gene. Diseases associated with FGFBP1 include colorectal adenocarcinoma, and adenocarcinoma. GO annotations related to this gene include fibroblast growth factor binding and heparin binding.

UniProtKB/Swiss-Prot: FGFP1_HUMAN, Q14512
Function: Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix
(EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair,
angiogenesis and in tumor growth

Gene Wiki entry for FGFBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006316.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGFBP1 gene promoter:
         RP58   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   POU3F2   Cdc5   E47   AREB6   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGFBP1 promoter sequence
   Search Chromatin IP Primers for FGFBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGFBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.32   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p15.32

FGFBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGFBP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M015937:  view genomic region     (about GC identifiers)

Start:
15,937,192 bp from pter      End:
15,940,363 bp from pter
Size:
3,172 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FGFP1_HUMAN, Q14512 (See protein sequence)
Recommended Name: Fibroblast growth factor-binding protein 1 precursor  
Size: 234 amino acids; 26264 Da
Subunit: Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2
Miscellaneous: Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell
carcinomas, some colon cancer cell lines and tumors
Secondary accessions: A8K5J2

Explore the universe of human proteins at neXtProt for FGFBP1: NX_Q14512

Explore proteomics data for FGFBP1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser37, Thr46, Thr73, Ser169, Thr179, Thr180, Ser182, Thr187, Thr189, Thr192
  • Modification sites at PhosphoSitePlus

  • See FGFBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005121.1  
    ENSEMBL proteins: 
     ENSP00000371770   ENSP00000259988  

    FGFBP1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FGFBP1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR010510 FGF1-bd

    Graphical View of Domain Structure for InterPro Entry Q14512

    ProtoNet protein and cluster: Q14512

    UniProtKB/Swiss-Prot: FGFP1_HUMAN, Q14512
    Similarity: Belongs to the fibroblast growth factor-binding protein family


    Find genes that share domains with FGFBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGFP1_HUMAN, Q14512
    Function: Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix
    (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair,
    angiogenesis and in tumor growth
    Induction: Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16257968
    GO:0008201heparin binding TAS1885605
    GO:0017134fibroblast growth factor binding IEA--
         
    Find genes that share ontologies with FGFBP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FGFBP1:
     Increased cell number in G1, s 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGFBP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGFBP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGFBP1

    miRNA
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    miRTarBase miRNAs that target FGFBP1:
    hsa-mir-124-3p (MIRT022832)

    Block miRNA regulation of human, mouse, rat FGFBP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FGFBP1
    SwitchGear 3'UTR luciferase reporter plasmidFGFBP1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGFP1_HUMAN, Q14512: Secreted, extracellular space. Cell membrane; Peripheral membrane protein.
    Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of
    squamous cell carcinomas
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IEA--

    Find genes that share ontologies with FGFBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGFBP1: 
              Angiogenic Growth Factors in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGFBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for FGFBP1 (Q145121, 2, 3 ENSP000002599884) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGF2P090381, 3, ENSP000002644984EBI-953742,EBI-977447 I2D: score=4 STRING: ENSP00000264498
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2867903 I2D: score=3 STRING: ENSP00000357292
    FGF1P052303, ENSP000003385484I2D: score=2 STRING: ENSP00000338548
    FIBPO434273, ENSP000003445724I2D: score=1 STRING: ENSP00000344572
    HSPG2P981603, ENSP000003638274I2D: score=2 STRING: ENSP00000363827
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS1885605
    GO:0007267cell-cell signaling TAS1885605
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0008285negative regulation of cell proliferation TAS1885605
    GO:0045743positive regulation of fibroblast growth factor receptor signaling pathway IEA--

    Find genes that share ontologies with FGFBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGFBP1 (FGFP1)

    1 HMDB Compound for FGFBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    3 Novoseek inferred chemical compound relationships for FGFBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    12-o-tetradecanoylphorbol 13-acetate 34.4 3 9668098 (1), 10871606 (1)
    heparin 26.5 1 11304685 (1)
    retinoic acid 14.4 3 11077050 (1), 10831072 (1)



    Find genes that share compounds with FGFBP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGFBP1 gene: 
    NM_005130.4  

    Unigene Cluster for FGFBP1:

    Fibroblast growth factor binding protein 1
    Hs.1690  [show with all ESTs]
    Unigene Representative Sequence: NM_005130
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382333(uc003gom.3) ENST00000259988
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FGFBP1
      QuantiFast Probe-based Assays in human, mouse, rat FGFBP1

    Additional mRNA sequence: 

    AK291307.1 BC003628.2 BC008910.2 BC018852.2 M60047.1 

    1 DOTS entry:

    DT.204229 

    Selected AceView cDNA sequences (see all 101):

    NM_005130 CR593039 AW873701 T28175 BM549370 BM847132 BE563406 BC003628 
    CB853439 BM763834 BM762070 BM840875 BM848302 AW293392 BE747141 BM844342 
    AI590882 BG319598 BM848474 AI333890 BM784632 BM842243 BM759134 BM844441 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGFBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCACACAG
    FGFBP1 Expression
    About this image


    FGFBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Thymus (Hematopoietic System)
             Thymus
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    FGFBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGFBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1690

    UniProtKB/Swiss-Prot: FGFP1_HUMAN, Q14512
    Tissue specificity: Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane
    at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels),
    wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded
    skin and various squamous cell carcinomas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGFBP1: 
              Angiogenic Growth Factors in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGFBP1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgfbp11 , 5 fibroblast growth factor binding protein 11, 5 72.99(n)1
    64.93(a)1
      5 (23.95 cM)5
    141811  NM_008009.41  NP_032035.21 
     439788655 
    chicken
    (Gallus gallus)
    Aves FGFBP16
    fibroblast growth factor binding protein 1
    32(a)
    1 ↔ 1
    4(76161317-76163848)
    zebrafish
    (Danio rerio)
    Actinopterygii fgfbp16
    fgfbp16
    fibroblast growth factor binding protein 1
    26(a)
    25(a)
    many → 1
    many → 1
    14(49377433-49378020) ENSDARG00000039963
    1(21451706-21452326) ENSDARG00000091660


    ENSEMBL Gene Tree for FGFBP1 (if available)
    TreeFam Gene Tree for FGFBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGFBP1 gene

    Find genes that share paralogs with FGFBP1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FGFBP1
    PGOHUM00000245857


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGFBP1 (see all 150)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851595101,2
    --15936699(+) CCCCTG/TCCTTT 1 -- ds50010--------
    rs1909867901,2
    --15936740(+) CTAGGC/TCTTTC 1 -- ds50010--------
    rs1504294591,2
    --15936827(+) GGGTGA/GGGGAG 1 -- ds50010--------
    rs1381184841,2
    C--15936840(+) AATGGA/GCAGCT 1 -- ds50010--------
    rs1495723591,2
    --15936864(+) GTAGCA/GGAGGT 1 -- ds50010--------
    rs1159624531,2
    C,F--15936934(+) TACCAT/ACTATG 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1810528441,2
    --15936935(+) ACCATC/TTATGA 1 -- ds50010--------
    rs7322441,2
    C,F,A,H--15937000(-) ACTAGG/AATCCC 1 -- ds500116Minor allele frequency- A:0.41EA NA NS CSA WA 835
    rs7322451,2
    C,F,A,H--15937085(+) ACTTGC/TGAAGG 1 -- ds500116Minor allele frequency- T:0.44EA NA NS CSA WA 931
    rs1872715801,2
    --15937151(+) CTTAAC/TGAGTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGFBP1 (15937192 - 15940363 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FGFBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv878715CNV Loss21882294
    dgv5484n71CNV Gain21882294
    nsv527861CNV Gain19592680
    dgv5485n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): FGFBP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGFBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for FGFBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607737    OMIM disorders: --

    2 diseases for FGFBP1:    
    About MalaCards
    colorectal adenocarcinoma    adenocarcinoma


    Find genes that share disorders with FGFBP1           About GenesLikeMe

    7 Novoseek inferred disease relationships for FGFBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 49.9 11 12910691 (2), 9668098 (1), 11077050 (1), 11291074 (1) (see all 7)
    tumors 34.5 39 9334727 (4), 11304685 (4), 11291074 (2), 19770422 (2) (see all 14)
    pathological processes 29 2 10831072 (1)
    cancer 17.2 4 14678957 (1), 10831072 (1), 10753873 (1), 15548369 (1)
    renal disease 0.477 6 16352855 (4), 11318942 (1)
    breast cancer 0 1 19668233 (1), 12670924 (1)
    carcinoma 0 2 11291074 (1), 12670924 (1)

    Genetic Association Database (GAD): FGFBP1
    Human Genome Epidemiology (HuGE) Navigator: FGFBP1 (3 documents)

    Export disorders for FGFBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGFBP1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with FGFBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. (PubMed id 11148217)1, 2, 3 Mongiat M.... Iozzo R.V. (J. Biol. Chem. 2001)
    2. Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. (PubMed id 1885605)1, 2, 3 Wu D.Q.... Sato J.D. (J. Biol. Chem. 1991)
    3. Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. (PubMed id 16257968)1, 2, 9 Xie B.... Wellstein A. (J. Biol. Chem. 2006)
    4. A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. (PubMed id 9334727)1, 2, 9 Czubayko F.... Wellstein A. (Nat. Med. 1997)
    5. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PubMed id 15806171)1, 2, 9 Beer H.-D....Werner S. (Oncogene 2005)
    6. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    7. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Enhancement of fibroblast growth factor (FGF) activity by an FGF- binding protein. (PubMed id 11509569)1, 2 Tassi E.... Wellstein A. (J. Biol. Chem. 2001)
    10. Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways. (PubMed id 10753873)1, 9 Harris V.K....Riegel A.T. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9982 HGNC: 19695 AceView: FGFBP1 Ensembl:ENSG00000137440 euGenes: HUgn9982
    ECgene: FGFBP1 H-InvDB: FGFBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGFBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGFBP1 gene:
    Search GeneIP for patents involving FGFBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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