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Aliases for FGFBP1 Gene

Aliases for FGFBP1 Gene

  • Fibroblast Growth Factor Binding Protein 1 2 3
  • FGFBP 3 4 6
  • HBP17 3 4 6
  • 17 KDa Heparin-Binding Growth Factor-Binding Protein 3 4
  • 17 KDa HBGF-Binding Protein 3 4
  • FGF-Binding Protein 1 3 4
  • FGF-BP1 3 4
  • FGFBP-1 3 4
  • FGF-BP 3 4
  • Heparin-Binding Growth Factor Binding Protein 3
  • Fibroblast Growth Factor-Binding Protein 1 3

External Ids for FGFBP1 Gene

Previous GeneCards Identifiers for FGFBP1 Gene

  • GC04M015689
  • GC04M015613
  • GC04M015546
  • GC04M015286

Summaries for FGFBP1 Gene

Entrez Gene Summary for FGFBP1 Gene

  • This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]

GeneCards Summary for FGFBP1 Gene

FGFBP1 (Fibroblast Growth Factor Binding Protein 1) is a Protein Coding gene. Diseases associated with FGFBP1 include colorectal adenocarcinoma and adenocarcinoma. GO annotations related to this gene include heparin binding and fibroblast growth factor binding.

UniProtKB/Swiss-Prot for FGFBP1 Gene

  • Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.

Gene Wiki entry for FGFBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFBP1 Gene

Genomics for FGFBP1 Gene

Regulatory Elements for FGFBP1 Gene

Genomic Location for FGFBP1 Gene

Start:
15,935,569 bp from pter
End:
15,938,740 bp from pter
Size:
3,172 bases
Orientation:
Minus strand

Genomic View for FGFBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGFBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFBP1 Gene

Proteins for FGFBP1 Gene

  • Protein details for FGFBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14512-FGFP1_HUMAN
    Recommended name:
    Fibroblast growth factor-binding protein 1
    Protein Accession:
    Q14512
    Secondary Accessions:
    • A8K5J2

    Protein attributes for FGFBP1 Gene

    Size:
    234 amino acids
    Molecular mass:
    26264 Da
    Quaternary structure:
    • Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2.
    Miscellaneous:
    • Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors

neXtProt entry for FGFBP1 Gene

Proteomics data for FGFBP1 Gene at MOPED

Post-translational modifications for FGFBP1 Gene

  • Glycosylation at Ser37, Thr46, Thr73, Ser169, Thr179, Thr180, Ser182, Thr187, Thr189, and Thr192
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGFBP1 Gene

Domains for FGFBP1 Gene

Protein Domains for FGFBP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FGFBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14512

UniProtKB/Swiss-Prot:

FGFP1_HUMAN :
  • Q14512
Family:
  • Belongs to the fibroblast growth factor-binding protein family.
genes like me logo Genes that share domains with FGFBP1: view

No data available for Gene Families for FGFBP1 Gene

Function for FGFBP1 Gene

Molecular function for FGFBP1 Gene

UniProtKB/Swiss-Prot Function: Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
UniProtKB/Swiss-Prot Induction: Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens.

Gene Ontology (GO) - Molecular Function for FGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16257968
GO:0008201 heparin binding TAS 1885605
GO:0017134 fibroblast growth factor binding IEA --
genes like me logo Genes that share ontologies with FGFBP1: view

Phenotypes for FGFBP1 Gene

GenomeRNAi human phenotypes for FGFBP1:
genes like me logo Genes that share phenotypes with FGFBP1: view

Animal Model Products

CRISPR Products

miRNA for FGFBP1 Gene

miRTarBase miRNAs that target FGFBP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGFBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FGFBP1 Gene

Localization for FGFBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFBP1 Gene

Secreted, extracellular space. Cell membrane; Peripheral membrane protein. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGFBP1 Gene COMPARTMENTS Subcellular localization image for FGFBP1 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for FGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with FGFBP1: view

Pathways for FGFBP1 Gene

SuperPathways for FGFBP1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Angiogenic Growth Factors in human,mouse,rat
    • Epithelial to Mesenchymal Transition (EMT) in human,mouse,rat

Interacting Proteins for FGFBP1 Gene

Gene Ontology (GO) - Biological Process for FGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0007165 signal transduction NAS 1885605
GO:0007267 cell-cell signaling TAS 1885605
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008285 negative regulation of cell proliferation TAS 1885605
genes like me logo Genes that share ontologies with FGFBP1: view

No data available for Pathways by source for FGFBP1 Gene

Compounds for FGFBP1 Gene

(1) HMDB Compounds for FGFBP1 Gene

Compound Synonyms Cas Number PubMed IDs
Heparin
  • Arteven
9005-49-6

(3) Novoseek inferred chemical compound relationships for FGFBP1 Gene

Compound -log(P) Hits PubMed IDs
12-o-tetradecanoylphorbol 13-acetate 34.4 2
heparin 26.5 1
retinoic acid 14.4 2
genes like me logo Genes that share compounds with FGFBP1: view

Transcripts for FGFBP1 Gene

mRNA/cDNA for FGFBP1 Gene

(101) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGFBP1 Gene

Fibroblast growth factor binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGFBP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFBP1 Gene

No ASD Table

Relevant External Links for FGFBP1 Gene

GeneLoc Exon Structure for
FGFBP1
ECgene alternative splicing isoforms for
FGFBP1

Expression for FGFBP1 Gene

mRNA expression in normal human tissues for FGFBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGFBP1 Gene

This gene is overexpressed in Esophagus - Mucosa (17.3), Minor Salivary Gland (16.8), Vagina (6.1), and Cervix - Ectocervix (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FGFBP1 Gene

SOURCE GeneReport for Unigene cluster for FGFBP1 Gene Hs.1690

mRNA Expression by UniProt/SwissProt for FGFBP1 Gene

Q14512-FGFP1_HUMAN
Tissue specificity: Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.
genes like me logo Genes that share expressions with FGFBP1: view

In Situ Assay Products

Orthologs for FGFBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGFBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGFBP1 35
  • 98.58 (n)
  • 98.72 (a)
FGFBP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGFBP1 35
  • 73.3 (n)
  • 59.72 (a)
FGFBP1 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGFBP1 36
  • 54 (a)
OneToOne
LOC488818 35
  • 73.68 (n)
  • 60.94 (a)
mouse
(Mus musculus)
Mammalia Fgfbp1 35
  • 72.99 (n)
  • 64.93 (a)
Fgfbp1 16
Fgfbp1 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGFBP1 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGFBP1 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgfbp1 35
  • 71.43 (n)
  • 60.1 (a)
chicken
(Gallus gallus)
Aves FGFBP1 36
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fgfbp1 36
  • 26 (a)
OneToMany
fgfbp1 36
  • 25 (a)
OneToMany
Species with no ortholog for FGFBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGFBP1 Gene

ENSEMBL:
Gene Tree for FGFBP1 (if available)
TreeFam:
Gene Tree for FGFBP1 (if available)

Paralogs for FGFBP1 Gene

Pseudogenes.org Pseudogenes for FGFBP1 Gene

genes like me logo Genes that share paralogs with FGFBP1: view

No data available for Paralogs for FGFBP1 Gene

Variants for FGFBP1 Gene

Sequence variations from dbSNP and Humsavar for FGFBP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs732244 -- 15,935,377(-) ACTAG(A/G)ATCCC downstream-variant-500B
rs732245 -- 15,935,462(+) ACTTG(C/T)GAAGG downstream-variant-500B
rs1042510 -- 15,935,903(-) GTTCC(C/T)TTAAG utr-variant-3-prime
rs1985753 -- 15,935,743(-) TGGAT(A/G)CGATG utr-variant-3-prime
rs2072313 -- 15,936,108(-) ATCAA(A/G)GGCAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FGFBP1 Gene

Variant ID Type Subtype PubMed ID
nsv878715 CNV Loss 21882294
nsv527861 CNV Gain 19592680
dgv5484n71 CNV Gain 21882294
dgv5485n71 CNV Gain 21882294

Relevant External Links for FGFBP1 Gene

HapMap Linkage Disequilibrium report
FGFBP1
Human Gene Mutation Database (HGMD)
FGFBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP1 Gene

Disorders for FGFBP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for FGFBP1 Gene including...

Search for FGFBP1 Gene in MalaCards »

(7) Novoseek inferred disease relationships for FGFBP1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 49.9 8
tumors 34.5 23
pathological processes 29 1
cancer 17.2 4
renal disease 0.477 5

Relevant External Links for FGFBP1

Genetic Association Database (GAD)
FGFBP1
Human Genome Epidemiology (HuGE) Navigator
FGFBP1
genes like me logo Genes that share disorders with FGFBP1: view

No data available for UniProtKB/Swiss-Prot for FGFBP1 Gene

Publications for FGFBP1 Gene

  1. A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. (PMID: 9334727) Czubayko F. … Wellstein A. (Nat. Med. 1997) 3 4 23
  2. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PMID: 15806171) Beer H.-D. … Werner S. (Oncogene 2005) 3 4 23
  3. Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. (PMID: 16257968) Xie B. … Wellstein A. (J. Biol. Chem. 2006) 3 4 23
  4. Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. (PMID: 1885605) Wu D.Q. … Sato J.D. (J. Biol. Chem. 1991) 2 3 4
  5. Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. (PMID: 11148217) Mongiat M. … Iozzo R.V. (J. Biol. Chem. 2001) 2 3 4

Products for FGFBP1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Angiogenic Growth Factors in human,mouse,rat
    • Epithelial to Mesenchymal Transition (EMT) in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FGFBP1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FGFBP1
    • Block miRNA regulation of FGFBP1 using miScript Target Protectors
    • antibodies-online proteins for FGFBP1
    • antibodies-online antibodies for FGFBP1
    • antibodies-online kits for FGFBP1

    Sources for FGFBP1 Gene

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