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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGFBP1 Gene

protein-coding   GIFtS: 52
GCID: GC04M015937

fibroblast growth factor binding protein 1
 Explore 12 diseases affiliated with
FGFBP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FGFBP1    

Aliases
for FGFBP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fibroblast Growth Factor Binding Protein 11 2     FGF-BP12 3
FGFBP1 2 3 5     FGFBP-12 3
HBP171 2 3 5     FGF-Binding Protein 12 3
17 KDa HBGF-Binding Protein2 3     Fibroblast Growth Factor-Binding Protein 12
17 KDa Heparin-Binding Growth Factor-Binding Protein2 3     Heparin-Binding Growth Factor Binding Protein2
FGF-BP2 3     HBp173

External Ids:    HGNC: 196951   Entrez Gene: 99822   Ensembl: ENSG000001374407   OMIM: 6077375   UniProtKB: Q145123   

Export aliases for FGFBP1 gene to outside databases

Previous GC identifers: GC04M015689 GC04M015613 GC04M015546 GC04M015286


Summaries
for FGFBP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FGFBP1:
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in
cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their
biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch
molecule, and expression of this gene has been associated with several types of cancer including pancreatic and
colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. (provided by
RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: FGFP1_HUMAN, Q14512
Function: Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM)
storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis
and in tumor growth

Gene Wiki entry for FGFBP1


Genomic Views
for FGFBP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGFBP1 gene promoter:
         RP58   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   POU3F2   Cdc5   E47   AREB6   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGFBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGFBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGFBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.32   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p15.32

FGFBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGFBP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M015937:  view genomic region     (about GC identifiers)

Start:
 15,937,192 bp from pter      End:
 15,940,363 bp from pter
Size:
 3,172 bases      Orientation:
 minus strand

Proteins
for FGFBP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FGFP1_HUMAN, Q14512 (See protein sequence)
Recommended Name: Fibroblast growth factor-binding protein 1 precursor  
Size: 234 amino acids; 26264 Da
Subunit: Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2
Subcellular location: Secreted, extracellular space. Cell membrane; Peripheral membrane protein. Note=Extracellular and
plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas
Miscellaneous: Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell
carcinomas, some colon cancer cell lines and tumors
Secondary accessions: A8K5J2

Explore the universe of human proteins at neXtProt for FGFBP1: NX_Q14512

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14512

    • FGFBP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005121.1  
    ENSEMBL proteins: 
     ENSP00000371770   ENSP00000259988  

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    Uscn Proteins for FGFBP1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IEA--


    FGFBP1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FGFBP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FGFBP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR010510 FGF1-bd

    Graphical View of Domain Structure for InterPro Entry Q14512

    ProtoNet protein and cluster: Q14512

    UniProtKB/Swiss-Prot: FGFP1_HUMAN, Q14512
    Similarity: Belongs to the fibroblast growth factor-binding protein family


    Function
    for FGFBP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FGFP1_HUMAN, Q14512
    Function: Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM)
    storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis
    and in tumor growth
    Induction: Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens

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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16257968
    GO:0008201heparin binding TAS1885605
    GO:0017134fibroblast growth factor binding IEA--


    FGFBP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FGFBP1:
     Increased cell number in G1, s 


    Pathways & Interactions
    for FGFBP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGFBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/10 Interacting proteins for FGFBP1 (Q145121, 2, 3 ENSP000002599884) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGF2P090381, 3, ENSP000002644984EBI-953742,EBI-977447 I2D: score=4 STRING: ENSP00000264498
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2867903 I2D: score=3 STRING: ENSP00000357292
    FGF1P052303, ENSP000003385484I2D: score=2 STRING: ENSP00000338548
    FIBPO434273, ENSP000003445724I2D: score=1 STRING: ENSP00000344572
    HSPG2P981603, ENSP000003638274I2D: score=2 STRING: ENSP00000363827
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS1885605
    GO:0007267cell-cell signaling TAS1885605
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0008285negative regulation of cell proliferation TAS1885605
    GO:0045743positive regulation of fibroblast growth factor receptor signaling pathway IEA--


    FGFBP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FGFBP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGFBP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FGFBP1

    1 HMDB Compound for FGFBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--
    3 Novoseek chemical compound relationships for FGFBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    12-o-tetradecanoylphorbol 13-acetate 34.4 3 9668098 (1), 10871606 (1)
    heparin 26.5 1 11304685 (1)
    retinoic acid 14.4 3 11077050 (1), 10831072 (1)

    Search CenterWatch for drugs/clinical trials and news about FGFBP1 / FGFP1 

    Transcripts
    for FGFBP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FGFBP1 gene: 
    NM_005130.4  

    Unigene Cluster for FGFBP1:

    Fibroblast growth factor binding protein 1
    Hs.1690  [show with all ESTs]
    Unigene Representative Sequence: NM_005130
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382333(uc003gom.3) ENST00000259988

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK291307.1 BC003628.2 BC008910.2 BC018852.2 M60047.1 

    1 DOTS entry:

    DT.204229 

    24/101 AceView cDNA sequences (see all 101):

    T28175 AW873701 CR593039 NM_005130 BM848302 BM761065 M60047 BC008910 
    CA314184 AI814629 BE563406 BG284029 CB159199 BM843581 BM844441 BM762070 
    BM819411 BM985280 BM018990 BM843662 BM782118 BM762590 BM847431 BM840875 

    GeneLoc Exon Structure


    Expression
    for FGFBP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGFBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCCACACAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FGFBP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    KidneyPodocyte LayerPodocytesKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FGFBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGFBP1

    SOURCE GeneReport for Unigene cluster: Hs.1690

    UniProtKB/Swiss-Prot: FGFP1_HUMAN, Q14512
    Tissue specificity: Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at
    the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin
    and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various
    squamous cell carcinomas

        SABiosciences Expression via Pathway-Focused PCR Arrays including FGFBP1: 
              Angiogenic Growth Factors in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for FGFBP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FGFBP1 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FGFBP11 fibroblast growth factor binding protein 1 48.59(n)
    36(a)    		   422826  XM_420773.2  XP_420773.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fgfbp11 fibroblast growth factor binding protein 1 48.05(n)
    31.82(a)    		   799002  XM_001339372.4  XP_001339408.2 


    ENSEMBL Gene Tree for FGFBP1 (if available)
    TreeFam Gene Tree for FGFBP1 (if available) 

    Paralogs
    for FGFBP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGFBP1 gene
    FGFBP22  

    FGFBP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FGFBP1
    PGOHUM00000245857


    Genomic Variants
    for FGFBP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): FGFBP1
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGFBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for FGFBP1

    Disorders / Diseases
    for FGFBP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FGFBP1 for disorders           About GeneDecksing

    OMIM gene information: 607737    OMIM disorders: --

    12 diseases for FGFBP1:    About MalaCards
    adenocarcinoma    hemolytic-uremic syndrome    pancreatitis    squamous cell carcinoma
    breast cancer    carcinoma    peritonitis    prostate carcinoma
    ataxia    hypertension    cerebritis    prostatitis

    7 Novoseek disease relationships for FGFBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 49.9 11 12910691 (2), 9668098 (1), 11077050 (1), 11291074 (1) (see all 7)
    tumors 34.5 39 9334727 (4), 11304685 (4), 11291074 (2), 19770422 (2) (see all 14)
    pathological processes 29 2 10831072 (1)
    cancer 17.2 4 14678957 (1), 10831072 (1), 10753873 (1), 15548369 (1)
    renal disease 0.477 6 16352855 (4), 11318942 (1)
    breast cancer 0 1 19668233 (1), 12670924 (1)
    carcinoma 0 2 11291074 (1), 12670924 (1)

    Human Genome Epidemiology (HuGE) Navigator: FGFBP1 (3 documents)

    Export disorders for FGFBP1 gene to outside databases

    Publications
    for FGFBP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGFBP1 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with FGFBP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. (PubMed id 11148217)1, 2, 3 Mongiat M.... Iozzo R.V. (2001)
    2. Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. (PubMed id 1885605)1, 2, 3 Wu D.Q....Sato J.D. (1991)
    3. Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. (PubMed id 16257968)1, 2, 9 Xie B.... Wellstein A. (2006)
    4. A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. (PubMed id 9334727)1, 2, 9 Czubayko F.... Wellstein A. (1997)
    5. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PubMed id 15806171)1, 2, 9 Beer H.-D....Werner S. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Enhancement of fibroblast growth factor (FGF) activity by an FGF- binding protein. (PubMed id 11509569)1, 2 Tassi E.... Wellstein A. (2001)
    8. Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways. (PubMed id 10753873)1, 9 Harris V.K....Riegel A.T. (2000)
    9. KrA1ppel-like factor 5 promotes breast cell proliferat ion partially through upregulating the transcription of fibroblast growth facto r binding protein 1. (PubMed id 19668233)1, 9 Zheng H.Q....Chen C. (2009)
    10. Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium. (PubMed id 11291074)1, 9 Sauter E.R....Herlyn M. (2001)

    External Searches for FGFBP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing FGFBP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9982 HGNC: 19695 AceView: FGFBP1 Ensembl:ENSG00000137440 euGenes: HUgn9982
    ECgene: FGFBP1 H-InvDB: FGFBP1

    Other Databases showing FGFBP1 gene

    (According to HUGE)
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    Specialized Databases showing FGFBP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGFBP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for FGFBP1 gene:
    Search GeneIP for patents involving FGFBP1

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