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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FGF9 Gene

protein-coding GIFtS: 66
GCID: GC13P022245

fibroblast growth factor 9 (glia-activating factor)

Explore 40 diseases affiliated with
FGF9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fibroblast Growth Factor 9 (Glia-Activating Factor)¹ ²		SYNS3² ⁵
Heparin-Binding Growth Factor 9² ³		HBFG-9²
FGF-9² ³		Fibroblast Growth Factor 9²
GAF² ³		Glia-Activating Factor³
HBGF-9² ³

External Ids:	HGNC: 3687¹	Entrez Gene: 2254²	Ensembl: ENSG00000102678⁷	OMIM: 600921⁵	UniProtKB: P31371³

Export aliases for FGF9 gene to outside databases

Previous GC identifers: GC13P020225 GC13P016225 GC13P021175 GC13P020044 GC13P020045 GC13P021144 GC13P003046

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF9:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess

broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including

embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated

as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this

protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog

of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a

male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371

Function: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation

and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair

and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation

of glial tumors

Gene Wiki entry for FGF9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FGF9 gene promoter:
Max1 Tal-1 Pax-5 Nkx2-5 HNF-4alpha1 E47 POU2F1 POU2F1a c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGF9 promoter sequence

Search SABiosciences Chromatin IP Primers for FGF9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q11-q12 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q11-q12

FGF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF9 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P022245: view genomic region (about GC identifiers)

Start:	22,245,215 bp from pter	End:	22,278,640 bp from pter
Size:	33,426 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371 (See protein sequence)

Recommended Name: Fibroblast growth factor 9 precursor

Size: 208 amino acids; 23441 Da

Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors

(FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors

Subcellular location: Secreted

Miscellaneous: Biochemical analysis of the Asn-99 mutation reveals a significantly impaired FGF signaling, as evidenced

by diminished activity of the MAPK1/MAPK2 pathway and decreases CTNNB1 and MYC expression when compared with wild-type

protein. Binding of mutant protein to the receptor FGFR3 is severely impaired, although homodimerization of mutant to

itself or wild-type is not detectably affected, providing a basis for the observed defective FGF9 signaling

2 PDB 3D structures from and Proteopedia for FGF9:

1G82 (3D)

1IHK (3D)

Secondary accessions: A8K427 Q3SY32

Explore the universe of human proteins at neXtProt for FGF9: NX_P31371

Post-translational modifications:

Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The

smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the

30 kDa species which is uncleavable in the secretion step¹

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P31371

FGF9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002001.1

ENSEMBL proteins:

ENSP00000371790

Reactome Protein details: P31371
Human Recombinant Protein Products:

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	Uscn Proteins for FGF9

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005604	basement membrane	IEA	--
GO:0005615	extracellular space	IDA	8321227
GO:0005737	cytoplasm	IEA	--

FGF9 for ontologies About GeneDecksing

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	ThermoFisher Antibody for FGF9

Assay Products for FGF9:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FGF9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FGF9 for domains About GeneDecksing

3 InterPro domains/families:

IPR002348 IL1_HBGF

IPR008996 Cytokine_IL1-like

IPR002209 GF_heparin-bd

Graphical View of Domain Structure for InterPro Entry P31371

ProtoNet protein and cluster: P31371

2 Blocks protein families:

IPB002209 Heparin binding growth factor family signature

IPB002348 IL1/HBGF family signature

UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371

Similarity: Belongs to the heparin-binding growth factors family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371

Function: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation

and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair

and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation

of glial tumors

Genatlas biochemistry entry for FGF9:

fibroblast growth factor 9

Summary:

During embryonic development, FGF9 as signaling molecule is secreted from the following cells: Endochondral Preosteoblasts in Sacral Vertebrae, Endochondral Preosteoblasts in Zeugopod Perichondrium (see all 9).

It affects the following cells: Cardiomyocytes in Myocardium, Endochondral Preosteoblasts in Autopod Perichondrium (see all 14).

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF9
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		hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-520e hsa-miR-376b hsa-miR-15a hsa-miR-485-3p

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF9

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005104	fibroblast growth factor receptor binding	IEA	--
GO:0008083	growth factor activity	IEA	--
GO:0008201	heparin binding	IEA	--

FGF9 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for FGF9: Fgf9^tm1.2Fwan Fgf9^tm1Dor
     15/18 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Fgf9) (see all 18):

behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	homeostasis/metabolism	integument
limbs/digits/tail	mortality/aging	muscle	normal	reproductive system

FGF9 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

FGFR2c binds to FGF

8/18 pathways (see all 18)
FGFR2c binds to FGF	1.00	FGFR4 ligand binding and activation	0.73
FGFR2c ligand binding and activation	1.00	FGFR1c ligand binding and activation	0.71
FGFR3c ligand binding and activation	0.79	Signaling by activated point mutants of FGFR1	0.71
FGFR3 ligand binding and activation	0.79	FGFR1 ligand binding and activation	0.59

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FGF9

Development FGF-family signaling

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF9

	P2Y Receptor Signaling
	FGF Pathway
	RhoGDI Pathway
	Regulation of eIF4 and p70S6K
	SOCS Pathway

1 GeneGo (Thomson Reuters) Pathway for FGF9

Development FGF-family signaling

1 BioSystems Pathway for FGF9

Regulation of Actin Cytoskeleton

5/58 Reactome Pathways for FGF9 (see all 58)

	FGFR2 ligand binding and activation
	FGFR ligand binding and activation
	Signaling by EGFR in Cancer
	Signaling by FGFR2 mutants
	Downstream signal transduction

4 Kegg Pathways (Kegg details for FGF9):

	MAPK signaling pathway
	Regulation of actin cytoskeleton
	Pathways in cancer
	Melanoma

FGF9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FGF9

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

5/21 Interacting proteins for FGF9 (P31371³ ENSP00000371790⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FGFR4	P22455³, ENSP00000292408⁴	I2D: score=1 STRING: ENSP00000292408
FGFR3	P22607³, ENSP00000260795⁴	I2D: score=2 STRING: ENSP00000260795
FGF1	ENSP00000338548⁴	STRING: ENSP00000338548
FGF10	ENSP00000264664⁴	STRING: ENSP00000264664
FGF18	ENSP00000274625⁴	STRING: ENSP00000274625

About this table

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001649	osteoblast differentiation	IEA	--
GO:0002053	positive regulation of mesenchymal cell proliferation	IEA	--
GO:0002062	chondrocyte differentiation	IEA	--
GO:0006606	protein import into nucleus	IEA	--

FGF9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FGF9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FGF9
7 Novoseek chemical compound relationships for FGF9 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	35.1	2	16452189 (1)
heparin	26.8	2	15058010 (1), 12820388 (1)
vegf	22.2	5	17082335 (2), 16377203 (1), 14872006 (1), 17881491 (1)
calcium	0	2	18093889 (3), 18978176 (2), 15760907 (1)
tyrosine	0	3	18336810 (1)
methionine	0	2	9139882 (1), 8321227 (1)
estrogen	0	4	14602803 (4)

Search CenterWatch for drugs/clinical trials and news about FGF9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FGF9 gene:

NM_002010.2

Unigene Cluster for FGF9:

Fibroblast growth factor 9 (glia-activating factor)

Hs.111 [show with all ESTs]

Unigene Representative Sequence: NM_002010

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000382353(uc001uog.2) ENST00000461657 ENST00000478546

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF9
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		hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-520e hsa-miR-376b hsa-miR-15a hsa-miR-485-3p

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Additional cDNA sequence:

AK095571.1 AK290792.1 BC069692.1 BC103978.1 BC103979.1 D14838.1

4 DOTS entries:

DT.206299 DT.65284556 DT.102823820 DT.75182799

24/38 AceView cDNA sequences (see all 38):

AI221350 BX402882 BM724935 BX110535 CD613709 BM720010 AI765602 AA989402

BX282365 NM_002010 AK095571 AW466928 BC069692 AI798776 BM926135 BM680164

AI334161 CD613707 D14838 AL583692 AI078616 BI827161 AI963033 D80569

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FGF9 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b
SP1:							-
SP2:

ECgene alternative splicing isoforms for FGF9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FGF9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGAAAAAA

About this image

FGF9 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/21 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 21)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Ectoderm

Apical Ectodermal Ridge Cells

Selective marker (cell-identifying gene)

Dermis, Ectoderm

Bone

Autopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Bone

Autopod Perichondrium

Endochondral Preosteoblasts

Bone

Cervical Vertebrae

Endochondral Preosteoblasts

Bone

Facial Sutures

Facial Presumptive Suture Cells

Bone

Facial Sutures

Facial Suture Cells

Bone

Lumbar Vertebrae

Endochondral Preosteoblasts

Bone

Rostral Skull Membranous Bones

Intramembrenous Osteocytes

Bone

Rostral Sutures

Rostral Presumptive Suture Cells

Bone

Rostral Sutures

Rostral Suture Cells

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FGF9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGF9

SOURCE GeneReport for Unigene cluster: Hs.111

UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371

Tissue specificity: Glial cells

SABiosciences Expression via Pathway-Focused PCR Arrays including FGF9:

Growth Factors in human mouse rat

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Targets in human mouse rat

Neurotrophins & Receptors in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FGF9 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FGF9¹	fibroblast growth factor 9 (glia-activating factor)	89.1(n) 97.6(a)		378917 NM_204399.1 NP_989730.1
lizard (Anolis carolinensis)	Reptilia	FGF9⁶	--	90(a)	1 ↔ 1	3(188009717-188052128)
African clawed frog (Xenopus laevis)	Amphibia	fgf9-A²	fibroblast growth factor 9 (glia-activating factor)	84.23(n)		U47622.1
worm (Caenorhabditis elegans)	Secernentea	let-756⁶	Protein let-756	14(a)	1 → many	III(6407076-6409965)

ENSEMBL Gene Tree for FGF9 (if available)
TreeFam Gene Tree for FGF9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FGF9 gene

FGF12² FGF5² FGF20² FGF16² FGF4² FGF6² FGF3² FGF7²

FGF11² FGF10² FGF13² FGF22² FGF14²

15 SIMAP similar genes for FGF9 using alignment to 1 protein entry: FGF9_HUMAN:

FGF20 FGF16 FGF10 FGF12 FGF7 FGF22

FGF13 FGF1 FGF11 FGF14 FGF6 FGF3

FGF5 FGF4 FGF2

FGF9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74925664^1,2	F,	--	3044973(+)	`TTTATG/TAGAAG`	1	--	us2k¹		1		WA	118
rs112265436^1,2	F,	--	3045034(+)	`AAGCCC/TGCTCT`	1	--	us2k¹		3		CSA WA	122
rs17069931^1,2	C,F,H,	--	3046501(+)	`CAGAGC/TCCCAG`	1	--	us2k¹		5		NS NA	864
rs78542788^1,2	F	--	3047377(+)	`GCCTGC/TTAAGA`	1	--	ut5¹		1		NA	4
rs17070006^1,2	C,	--	3048357(+)	`TGTGCC/ACAAAT`	1	--	int¹		1		NS	176
rs17070033^1,2	C,	--	3048634(+)	`TTTCCA/CTNNNN`	1	--	int¹		3		NS NA EA	416
rs17070036^1,2	C,	--	3048661(+)	`TCTCCT/AGNNNN`	1	--	int¹		3		NS NA EA	416
rs17070039^1,2	C,	--	3048662(+)	`CTCCTG/CCGTGG`	1	--	int¹		3		NS NA EA	416
rs17070044^1,2	C,	--	3048866(+)	`AGTCAA/GCTAAC`	1	--	int¹		1		NS	172
rs7999132^1,2	C,	--	3048893(+)	`GGACTC/GTTGAG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FGF9 (22245215 - 22278640 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FGF9
1 CNV: 4797
Human Gene Mutation Database (HGMD): FGF9

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF9

DNA2.0 Custom Variant and Variant Library Synthesis for FGF9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FGF9 for disorders           About GeneDecksing

OMIM gene information: 600921
OMIM disorders: 612961
UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371

Defects in FGF9 are the cause of multiple synostoses syndrome type 3 (SYNS3) [MIM:612961]. Multiple synostoses

syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles

and cervical spine, characteristic facies and progressive conductive deafness

20/40 diseases for FGF9 (see all 40): About MalaCards

sex reversal xy sex reversal synostoses syndrome cleft lip/palate

synovial chondromatosis multiple synostoses syndrome 3 cystic adenomatoid malformation of lung cleft lip

thanatophoric dysplasia craniosynostosis moebius syndrome ladd syndrome

clouston syndrome osteochondroma achondroplasia chronic lymphocytic leukemia

craniosynostosis, syndromic mood disorder lymphocytic leukemia neuronitis

1 disease from the University of Copenhagen DISEASES database for FGF9:

Achondroplasia

10/12 Novoseek disease relationships for FGF9 gene (see all 12) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian endometrioid adenocarcinoma	72.4	1	16452189 (1)
craniosynostosis	48.7	2	14613973 (1)
glioma	35.5	15	9864407 (3), 9696088 (2), 9139882 (1), 8321227 (1) (see all 7)
neoplastic transformation	20.3	2	16452189 (1)
nsclc	6.51	6	18849352 (4), 19358281 (1)
glioblastoma	5.8	4	9696088 (1), 9507114 (1)
endometriosis	4.16	3	14602803 (1), 16982695 (1)
hypertrophy	0	1	17544391 (1)
brain tumors	0	5	9696088 (4)
tumors	0	18	9696088 (3), 18165946 (3), 9139882 (2), 16452189 (1) (see all 8)

Human Genome Epidemiology (HuGE) Navigator: FGF9 (6 documents)

Export disorders for FGF9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FGF9 gene, integrated from 9 sources (see all 147):
(articles sorted by number of sources associating them with FGF9)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. (PubMed id 8321227)^{1, 2, 3, 9} Miyamoto M.... Kurokawa T. (1993)
Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. (PubMed id 11060292)^{1, 2, 9} Plotnikov A.N....Mohammadi M. (2001)
Multiple synostoses syndrome is due to a missense mut ation in exon 2 of FGF9 gene. (PubMed id 19589401)^{1, 2, 9} Wu X.L....Wang Z.G. (2009)
Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces. (PubMed id 11223514)^{1, 2, 9} Hecht H.J.... Yayon A. (2001)
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)^{1, 2} Zhang X....Ornitz D.M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)^{1, 2} Ornitz D.M....Goldfarb M. (1996)
Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties. (PubMed id 8428960)^{1, 2} Naruo K....Kurokawa T. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2254	HGNC: 3687	AceView: FGF9	Ensembl:ENSG00000102678	euGenes: HUgn2254
ECgene: FGF9	Kegg: 2254	H-InvDB: FGF9

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FGF9	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FGF9	Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine source book: FGF-9	http://www.rndsystems.com/molecule_detail.aspx?m=1436
NIEHS-SNPs	http://egp.gs.washington.edu/data/fgf9/

Intellectual Property for FGF9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FGF9 gene:
Search GeneIP for patents involving FGF9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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fibroblast growth factor 9 (glia-activating factor)

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FGF9 Gene

fibroblast growth factor 9 (glia-activating factor)

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