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FGF9 Gene

protein-coding   GIFtS: 67
GCID: GC13P022245

Fibroblast Growth Factor 9

(Previous name: fibroblast growth factor 9 (glia-activating factor))
  See FGF9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 91 2     GAF2 3
Fibroblast Growth Factor 9 (Glia-Activating Factor)1 2     HBGF-92 3
Glia-Activating Factor1 3     SYNS32 5
Heparin-Binding Growth Factor 92 3     HBFG-92
FGF-92 3     

External Ids:    HGNC: 36871   Entrez Gene: 22542   Ensembl: ENSG000001026787   OMIM: 6009215   UniProtKB: P313713   

Export aliases for FGF9 gene to outside databases

Previous GC identifers: GC13P020225 GC13P016225 GC13P021175 GC13P020044 GC13P020045 GC13P021144 GC13P003046


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF9 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This
protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In
nervous system, this protein is produced mainly by neurons and may be important for glial cell development.
Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice
lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular
embryogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF9 Gene:
FGF9 (fibroblast growth factor 9) is a protein-coding gene. Diseases associated with FGF9 include multiple synostoses syndrome 3, and synovial chondromatosis. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371
Function: Plays an important role in the regulation of embryonic development, cell proliferation, cell
differentiation and cell migration. May have a role in glial cell growth and differentiation during development,
gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal
cells, and growth stimulation of glial tumors

Gene Wiki entry for FGF9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF9 gene promoter:
         Max1   Tal-1   Pax-5   Nkx2-5   HNF-4alpha1   E47   POU2F1   POU2F1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF9 promoter sequence
   Search Chromatin IP Primers for FGF9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q11-q12   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q11-q12

FGF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF9 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P022245:  view genomic region     (about GC identifiers)

Start:
22,245,215 bp from pter      End:
22,278,640 bp from pter
Size:
33,426 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371 (See protein sequence)
Recommended Name: Fibroblast growth factor 9 precursor  
Size: 208 amino acids; 23441 Da
Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth
factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as
coreceptors
Miscellaneous: Biochemical analysis of the Asn-99 mutation reveals a significantly impaired FGF signaling, as
evidenced by diminished activity of the MAPK1/MAPK2 pathway and decreases CTNNB1 and MYC expression when compared
with wild-type protein. Binding of mutant protein to the receptor FGFR3 is severely impaired, although
homodimerization of mutant to itself or wild-type is not detectably affected, providing a basis for the observed
defective FGF9 signaling
2 PDB 3D structures from and Proteopedia for FGF9:
1G82 (3D)        1IHK (3D)    
Secondary accessions: A8K427 Q3SY32

Explore the universe of human proteins at neXtProt for FGF9: NX_P31371

Explore proteomics data for FGF9 at MOPED

Post-translational modifications: 

  • Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively.
    The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal
    sequence in the 30 kDa species which is uncleavable in the secretion step1
  • N-glycosylated1
  • Glycosylation2 at Asn79

  • See FGF9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002001.1  
    ENSEMBL proteins: 
     ENSP00000371790  
    Reactome Protein details: P31371

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    Cloud-Clone Corp. Proteins for FGF9

     
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    antibodies-online proteins for FGF9 (75 products) 

     
    antibodies-online peptides for FGF9

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    antibodies-online kits for FGF9 (43 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR028251 FGF9
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam

    Graphical View of Domain Structure for InterPro Entry P31371

    ProtoNet protein and cluster: P31371

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371
    Similarity: Belongs to the heparin-binding growth factors family


    Find genes that share domains with FGF9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF9_HUMAN, P31371
    Function: Plays an important role in the regulation of embryonic development, cell proliferation, cell
    differentiation and cell migration. May have a role in glial cell growth and differentiation during development,
    gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal
    cells, and growth stimulation of glial tumors

         Genatlas biochemistry entry for FGF9:
    fibroblast growth factor 9

         Summary: 
    During embryonic development, FGF9 as signaling molecule is secreted from the following cells:
          selected tissues (see all 3)      fully expand
    Bone: Endochondral Preosteoblasts (Rib), Endochondral Preosteoblasts (Vertebrae)      fully expand to see all 5 cells
    Head Mesenchyme: Ectoderm Cells (Branchial Arch 1)

    It affects the following cells:
          selected tissues (see all 5)      fully expand
    Bone: Endochondral Preosteoblasts (Autopod Perichondrium), Hypertrophic Chondrocytes (Zeugopod Perichondrium)      fully expand to see all 9 cells
    Head Mesenchyme: Dental Mesenchymal Cells (Branchial Arch 1), Cranial Neural Crest Cells (Branchial Arch 1)      fully expand to see all 2 cells

    FGF9 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                fully expand
    Kidney: Renal progenitor cells, Cap mesenchyme-like cells      fully expand to see all 3 cells
    Intermediate Mesoderm: Intermediate mesoderm cells, Intermediate mesoderm cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IEA--
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with FGF9           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Fgf9) (see all 18):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  muscle  normal  reproductive system 

    Find genes that share phenotypes with FGF9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FGF9: Fgf9tm1.2Fwan Fgf9tm1Dor

       genOway: Develop your customized and physiologically relevant rodent model for FGF9

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FGF9 (see all 123):
    hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-520e hsa-miR-376b hsa-miR-15a hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidFGF9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FGF9

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: FGF9 (NM_002010)
    Sino Biological Human cDNA Clone for FGF9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF9

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF9_HUMAN, P31371: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA8321227
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with FGF9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF9 About   (see all 22)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR4 ligand binding and activation0.00
    SHC-mediated cascade0.79
    FGFR1 ligand binding and activation0.00
    FGFR2 ligand binding and activation0.74
    Activated point mutants of FGFR20.00
    FRS2-mediated cascade0.70
    Signaling by FGFR2 mutants0.00
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    4Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    5Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    IRS-related events triggered by IGF1R0.92
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PI3K Cascade0.87
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.80


    Find genes that share SuperPaths with FGF9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF9
        P2Y Receptor Signaling
    FGF Pathway
    RhoGDI Pathway
    Regulation of eIF4 and p70S6K
    SOCS Pathway

    1 GeneGo (Thomson Reuters) Pathway for FGF9
        Development FGF-family signaling

    1 BioSystems Pathway for FGF9
        Regulation of Actin Cytoskeleton


    Selected Reactome Pathways for FGF9 (see all 18)
        Signaling by activated point mutants of FGFR1
    FRS2-mediated cascade
    FGFR4 ligand binding and activation
    Negative regulation of FGFR signaling
    Activated point mutants of FGFR2


    Selected Kegg Pathways  (Kegg details for FGF9) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF9: 
              Growth Factors in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Targets in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGF9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGF9 (P313713 ENSP000003717904) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR4P224553, ENSP000002924084I2D: score=1 STRING: ENSP00000292408
    FGFR3P226073, ENSP000002607954I2D: score=2 STRING: ENSP00000260795
    FGF1ENSP000003385484STRING: ENSP00000338548
    FGF10ENSP000002646644STRING: ENSP00000264664
    FGF18ENSP000002746254STRING: ENSP00000274625
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001525angiogenesis IEA--
    GO:0001649osteoblast differentiation IEA--
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0002062chondrocyte differentiation IEA--

    Find genes that share ontologies with FGF9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF9

    7 Novoseek inferred chemical compound relationships for FGF9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 35.1 2 16452189 (1)
    heparin 26.8 2 15058010 (1), 12820388 (1)
    vegf 22.2 5 17082335 (2), 16377203 (1), 14872006 (1), 17881491 (1)
    calcium 0 2 18093889 (3), 18978176 (2), 15760907 (1)
    tyrosine 0 3 18336810 (1)
    methionine 0 2 9139882 (1), 8321227 (1)
    estrogen 0 4 14602803 (4)



    Find genes that share compounds with FGF9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGF9 gene: 
    NM_002010.2  

    Unigene Cluster for FGF9:

    Fibroblast growth factor 9 (glia-activating factor)
    Hs.111  [show with all ESTs]
    Unigene Representative Sequence: NM_002010
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382353(uc001uog.2) ENST00000461657 ENST00000478546
    miRNA
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    hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-520e hsa-miR-376b hsa-miR-15a hsa-miR-485-3p
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      QuantiFast Probe-based Assays in human, mouse, rat FGF9

    Additional mRNA sequence: 

    AK095571.1 AK290792.1 BC069692.1 BC103978.1 BC103979.1 D14838.1 

    4 DOTS entries:

    DT.206299  DT.65284556  DT.102823820  DT.75182799 

    Selected AceView cDNA sequences (see all 38):

    BM724935 BX402882 AI221350 BX110535 AI963033 AA989402 CD613707 AI334161 
    AW466928 NM_002010 D14838 AI078616 BI827161 BM926135 BM680164 BC069692 
    BX282365 AI798776 AI765602 AK095571 CD613709 BM720010 AL583692 BG398877 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FGF9    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b
    SP1:                    -               
    SP2:                                    


    ECgene alternative splicing isoforms for FGF9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGF9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGAAAAAA
    FGF9 Expression
    About this image


    FGF9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 16 entries
             Endochondral Preosteoblasts Vertebrae
             Membranous Facial Bones
             Bone marrow-derived mesenchymal stem cells
     
     Ectoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
     
     Mesenchymal Stem Cells
             Placenta-derived mesenchymal stem cells (family)
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
             Floor plate-like cells
    FGF9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.111

    UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371
    Tissue specificity: Glial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF9: 
              Growth Factors in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Targets in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF9 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf91 , 5 fibroblast growth factor 91, 5 92.47(n)1
    99.52(a)1
      14 (30.51 cM)5
    141801  NM_013518.41  NP_038546.21 
     580705475 
    chicken
    (Gallus gallus)
    Aves FGF91 fibroblast growth factor 9 (glia-activating factor) 89.1(n)
    97.6(a)
      378917  NM_204399.1  NP_989730.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF96
    fibroblast growth factor 9
    93(a)
    1 ↔ 1
    3(188009617-188056526)
    African clawed frog
    (Xenopus laevis)
    Amphibia fgf9-A2 fibroblast growth factor 9 (glia-activating factor) 84.23(n)    U47622.1 


    ENSEMBL Gene Tree for FGF9 (if available)
    TreeFam Gene Tree for FGF9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF9 gene
    FGF122  FGF162  FGF52  FGF202  FGF42  FGF62  FGF32  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    15 SIMAP similar genes for FGF9 using alignment to 1 protein entry:     FGF9_HUMAN:
    FGF20    FGF16    FGF10    FGF12    FGF7    FGF22
    FGF13    FGF1    FGF11    FGF14    FGF6    FGF3
    FGF5    FGF4    FGF2

    Find genes that share paralogs with FGF9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF9 (see all 666)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0632544
    Multiple synostoses syndrome 3 (SYNS3)4--see VAR_0632542 S N mis40--------
    rs106242651,2
    C--3047547(+) TTTTT-/T/TT  
            
    CTCTC
    2 -- ut51 trp31CSA 2
    rs1905925761,2
    --3197422(+) CCTGTA/CTCTGT 1 -- us2k10--------
    rs749256641,2
    F--3197560(+) TTTATG/TAGAAG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs18868611,2
    C,F,A,H--3197575(+) ACTTAA/CTACCC 1 -- us2k122Minor allele frequency- C:0.33NS EA NA CSA WA 2528
    rs1122654361,2
    C,F--3197621(+) AAGCCC/TGCTCT 1 -- us2k13Minor allele frequency- T:0.05CSA WA 122
    rs1483696421,2
    C--3197634(+) ACCACC/GGCGGA 1 -- us2k10--------
    rs2021815271,2
    C--3197746(+) GCAAA-/GGGGGG 1 -- us2k10--------
    rs1415780541,2
    --3197749(+) AAAGGG/TGGGGT 1 -- us2k10--------
    rs1925079671,2
    --3197812(+) GGGCCA/GGAGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FGF9 (22245215 - 22278640 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FGF9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509497CNV Insertion20534489
    nsv832560CNV Loss17160897
    nsv899879CNV Gain21882294

    Human Gene Mutation Database (HGMD): FGF9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF9
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600921   
    OMIM disorders: 612961  
    UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371
  • Multiple synostoses syndrome 3 (SYNS3) [MIM:612961]: A bone disease characterized by multiple progressive
    joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine
    joints. Additional features can include progressive conductive deafness and facial dysmorphism. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 7 diseases for FGF9:    
    About MalaCards
    multiple synostoses syndrome 3    synovial chondromatosis    multiple synostosis syndrome 1    multiple synostoses syndrome
    moebius syndrome    osteochondroma    thanatophoric dysplasia

    1 disease from the University of Copenhagen DISEASES database for FGF9:
    Achondroplasia

    Find genes that share disorders with FGF9           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FGF9 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian endometrioid adenocarcinoma 72.4 1 16452189 (1)
    craniosynostosis 48.7 2 14613973 (1)
    glioma 35.5 15 9864407 (3), 9696088 (2), 9139882 (1), 8321227 (1) (see all 7)
    neoplastic transformation 20.3 2 16452189 (1)
    nsclc 6.51 6 18849352 (4), 19358281 (1)
    glioblastoma 5.8 4 9696088 (1), 9507114 (1)
    endometriosis 4.16 3 14602803 (1), 16982695 (1)
    hypertrophy 0 1 17544391 (1)
    brain tumors 0 5 9696088 (4)
    tumors 0 18 9696088 (3), 18165946 (3), 9139882 (2), 16452189 (1) (see all 8)

    Genetic Association Database (GAD): FGF9
    Human Genome Epidemiology (HuGE) Navigator: FGF9 (6 documents)

    Export disorders for FGF9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF9 gene, integrated from 10 sources (see all 163):
    (articles sorted by number of sources associating them with FGF9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. (PubMed id 8321227)1, 2, 3, 9 Miyamoto M.... Kurokawa T. (Mol. Cell. Biol. 1993)
    2. Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. (PubMed id 11060292)1, 2, 9 Plotnikov A.N.... Mohammadi M. (J. Biol. Chem. 2001)
    3. Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. (PubMed id 19589401)1, 2, 9 Wu X.L.... Wang Z.G. (Am. J. Hum. Genet. 2009)
    4. Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces. (PubMed id 11223514)1, 2, 9 Hecht H.J.... Yayon A. (Acta Crystallogr. D 2001)
    5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    6. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    7. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    8. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 2 Zhang X....Ornitz D.M. (J. Biol. Chem. 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2254 HGNC: 3687 AceView: FGF9 Ensembl:ENSG00000102678 euGenes: HUgn2254
    ECgene: FGF9 Kegg: 2254 H-InvDB: FGF9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGF9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF9 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: FGF-9http://www.rndsystems.com/molecule_detail.aspx?m=1436
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF9 gene:
    Search GeneIP for patents involving FGF9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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