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Aliases for FGF9 Gene

Aliases for FGF9 Gene

  • Fibroblast Growth Factor 9 2 3
  • Fibroblast Growth Factor 9 (Glia-Activating Factor) 2 3
  • Heparin-Binding Growth Factor 9 3 4
  • Glia-Activating Factor 2 4
  • HBGF-9 3 4
  • SYNS3 3 6
  • FGF-9 3 4
  • GAF 3 4
  • HBFG-9 3

External Ids for FGF9 Gene

Summaries for FGF9 Gene

Entrez Gene Summary for FGF9 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF9 Gene

FGF9 (Fibroblast Growth Factor 9) is a Protein Coding gene. Diseases associated with FGF9 include multiple synostoses syndrome 3 and synovial chondromatosis. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF9 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

Gene Wiki entry for FGF9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF9 Gene

Genomics for FGF9 Gene

Genomic Location for FGF9 Gene

21,671,076 bp from pter
21,704,501 bp from pter
33,426 bases
Plus strand

Genomic View for FGF9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF9 Gene

Regulatory Elements for FGF9 Gene

Proteins for FGF9 Gene

  • Protein details for FGF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibroblast growth factor 9
    Protein Accession:
    Secondary Accessions:
    • A8K427
    • Q3SY32

    Protein attributes for FGF9 Gene

    208 amino acids
    Molecular mass:
    23441 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
    • Biochemical analysis of the Asn-99 mutation reveals a significantly impaired FGF signaling, as evidenced by diminished activity of the MAPK1/MAPK2 pathway and decreases CTNNB1 and MYC expression when compared with wild-type protein. Binding of mutant protein to the receptor FGFR3 is severely impaired, although homodimerization of mutant to itself or wild-type is not detectably affected, providing a basis for the observed defective FGF9 signaling

    Three dimensional structures from OCA and Proteopedia for FGF9 Gene

neXtProt entry for FGF9 Gene

Proteomics data for FGF9 Gene at MOPED

Post-translational modifications for FGF9 Gene

  • N-glycosylated
  • Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step
  • Glycosylation at Asn79

Other Protein References for FGF9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF9 Gene

Domains for FGF9 Gene

Gene Families for FGF9 Gene



  • Belongs to the heparin-binding growth factors family.:
    • P31371
genes like me logo Genes that share domains with FGF9: view

Function for FGF9 Gene

Molecular function for FGF9 Gene

GENATLAS Biochemistry: fibroblast growth factor 9
UniProtKB/Swiss-Prot Function: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

Gene Ontology (GO) - Molecular Function for FGF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with FGF9: view
genes like me logo Genes that share phenotypes with FGF9: view

Animal Models for FGF9 Gene

MGI Knock Outs for FGF9:

miRNA for FGF9 Gene

miRTarBase miRNAs that target FGF9

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FGF9 Gene

Localization for FGF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF9 Gene


Subcellular locations from

Jensen Localization Image for FGF9 Gene COMPARTMENTS Subcellular localization image for FGF9 gene
Compartment Confidence
extracellular 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FGF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IDA 8321227
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FGF9: view

Pathways for FGF9 Gene

SuperPathways for FGF9 Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 FGFR ligand binding and activation
4 Insulin receptor signalling cascade
5 Signaling by FGFR3 mutants
genes like me logo Genes that share pathways with FGF9: view

Pathways by source for FGF9 Gene

Gene Ontology (GO) - Biological Process for FGF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001525 angiogenesis IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0002062 chondrocyte differentiation IEA --
genes like me logo Genes that share ontologies with FGF9: view

Compounds for FGF9 Gene

(7) Novoseek inferred chemical compound relationships for FGF9 Gene

Compound -log(P) Hits PubMed IDs
matrigel 35.1 1
heparin 26.8 2
vegf 22.2 5
calcium 0 6
tyrosine 0 1
genes like me logo Genes that share compounds with FGF9: view

Transcripts for FGF9 Gene

mRNA/cDNA for FGF9 Gene

Unigene Clusters for FGF9 Gene

Fibroblast growth factor 9 (glia-activating factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGF9 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b
SP1: -

Relevant External Links for FGF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGF9 Gene

mRNA expression in normal human tissues for FGF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF9 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (7.8) and Brain - Cerebellum (6.7).

SOURCE GeneReport for Unigene cluster for FGF9 Gene Hs.111

mRNA Expression by UniProt/SwissProt for FGF9 Gene

Tissue specificity: Glial cells
genes like me logo Genes that share expressions with FGF9: view

Orthologs for FGF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FGF9 36
  • 100 (n)
  • 100 (a)
FGF9 37
  • 100 (a)
(Bos Taurus)
Mammalia FGF9 36
  • 90.22 (n)
  • 99.04 (a)
FGF9 37
  • 99 (a)
(Canis familiaris)
Mammalia FGF9 36
  • 97.12 (n)
  • 100 (a)
FGF9 37
  • 100 (a)
(Mus musculus)
Mammalia Fgf9 36
  • 92.47 (n)
  • 99.52 (a)
Fgf9 16
Fgf9 37
  • 100 (a)
(Monodelphis domestica)
Mammalia FGF9 37
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia FGF9 37
  • 94 (a)
(Rattus norvegicus)
Mammalia Fgf9 36
  • 93.75 (n)
  • 99.52 (a)
(Gallus gallus)
Aves FGF9 36
  • 89.1 (n)
  • 97.6 (a)
FGF9 37
  • 98 (a)
(Anolis carolinensis)
Reptilia FGF9 37
  • 93 (a)
African clawed frog
(Xenopus laevis)
Amphibia fgf9-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf9 36
  • 84.78 (n)
  • 93.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 37
  • 25 (a)
Species with no ortholog for FGF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FGF9 Gene

Gene Tree for FGF9 (if available)
Gene Tree for FGF9 (if available)

Paralogs for FGF9 Gene

Paralogs for FGF9 Gene

Selected SIMAP similar genes for FGF9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FGF9: view

Variants for FGF9 Gene

Sequence variations from dbSNP and Humsavar for FGF9 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs3715 -- 21,702,529(+) GCTTT(C/T)ATTTT utr-variant-3-prime
rs518544 -- 21,701,054(+) ATGTG(C/T)AGGAT intron-variant
rs519234 -- 21,701,071(+) GTTTG(C/T)TAAAT intron-variant
rs546782 -- 21,701,807(+) GGAAA(A/T)AGACA utr-variant-3-prime
rs647236 -- 21,700,988(+) TAATT(A/T)TGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF9 Gene

Variant ID Type Subtype PubMed ID
nsv832560 CNV Loss 17160897
nsv509497 CNV Insertion 20534489
nsv899879 CNV Gain 21882294

Relevant External Links for FGF9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for FGF9 Gene

(1) OMIM Diseases for FGF9 Gene (600921)


  • Multiple synostoses syndrome 3 (SYNS3) [MIM:612961]: A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism. {ECO:0000269 PubMed:19589401}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for FGF9 Gene

(12) Novoseek inferred disease relationships for FGF9 Gene

Disease -log(P) Hits PubMed IDs
ovarian endometrioid adenocarcinoma 72.4 1
craniosynostosis 48.7 1
glioma 35.5 10
neoplastic transformation 20.3 1
nsclc 6.51 5

Relevant External Links for FGF9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FGF9: view

Publications for FGF9 Gene

  1. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. (PMID: 8321227) Miyamoto M. … Kurokawa T. (Mol. Cell. Biol. 1993) 2 3 4 23
  2. Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces. (PMID: 11223514) Hecht H.J. … Yayon A. (Acta Crystallogr. D 2001) 3 4 23
  3. Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. (PMID: 11060292) Plotnikov A.N. … Mohammadi M. (J. Biol. Chem. 2001) 3 4 23
  4. Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. (PMID: 19589401) Wu X.L. … Wang Z.G. (Am. J. Hum. Genet. 2009) 3 4 23
  5. Molecular genetic screening of MBS1 locus on chromosome 13 for microdeletions and exclusion of FGF9, GSH1 and CDX2 as causative genes in patients with Moebius syndrome. (PMID: 19460469) Uzumcu A. … Basaran S. (Eur J Med Genet 2009) 3 23

Products for FGF9 Gene

Sources for FGF9 Gene

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