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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF9 Gene

protein-coding   GIFtS: 67
GCID: GC13P022245

Fibroblast Growth Factor 9

(Previous name: fibroblast growth factor 9 (glia-activating factor))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibroblast Growth Factor 91 2     GAF2 3
Fibroblast Growth Factor 9 (Glia-Activating Factor)1 2     HBGF-92 3
Glia-Activating Factor1 3     SYNS32 5
Heparin-Binding Growth Factor 92 3     HBFG-92
FGF-92 3     

External Ids:    HGNC: 36871   Entrez Gene: 22542   Ensembl: ENSG000001026787   OMIM: 6009215   UniProtKB: P313713   

Export aliases for FGF9 gene to outside databases

Previous GC identifers: GC13P020225 GC13P016225 GC13P021175 GC13P020044 GC13P020045 GC13P021144 GC13P003046


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF9 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This
protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In
nervous system, this protein is produced mainly by neurons and may be important for glial cell development.
Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice
lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular
embryogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF9 Gene: 
FGF9 (fibroblast growth factor 9) is a protein-coding gene. Diseases associated with FGF9 include cystic adenomatoid malformation of lung, and synovial chondromatosis, and among its related super-pathways are Regulation of actin cytoskeleton and Development FGF-family signaling. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371
Function: Plays an important role in the regulation of embryonic development, cell proliferation, cell
differentiation and cell migration. May have a role in glial cell growth and differentiation during development,
gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal
cells, and growth stimulation of glial tumors

Gene Wiki entry for FGF9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF9 gene promoter:
         Max1   Tal-1   Pax-5   Nkx2-5   HNF-4alpha1   E47   POU2F1   POU2F1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF9 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q11-q12   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q11-q12

FGF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF9 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P022245:  view genomic region     (about GC identifiers)

Start:
22,245,215 bp from pter      End:
22,278,640 bp from pter
Size:
33,426 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371 (See protein sequence)
Recommended Name: Fibroblast growth factor 9 precursor  
Size: 208 amino acids; 23441 Da
Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth
factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as
coreceptors
Subcellular location: Secreted
Miscellaneous: Biochemical analysis of the Asn-99 mutation reveals a significantly impaired FGF signaling, as
evidenced by diminished activity of the MAPK1/MAPK2 pathway and decreases CTNNB1 and MYC expression when compared
with wild-type protein. Binding of mutant protein to the receptor FGFR3 is severely impaired, although
homodimerization of mutant to itself or wild-type is not detectably affected, providing a basis for the observed
defective FGF9 signaling
2 PDB 3D structures from and Proteopedia for FGF9:
1G82 (3D)        1IHK (3D)    
Secondary accessions: A8K427 Q3SY32

Explore the universe of human proteins at neXtProt for FGF9: NX_P31371

Explore proteomics data for FGF9 at MOPED 

Post-translational modifications:

  • UniProtKB: Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively.
    The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal
    sequence in the 30 kDa species which is uncleavable in the secretion step
  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P31371

  • FGF9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FGF9 Protein Expression
    REFSEQ proteins: NP_002001.1  
    ENSEMBL proteins: 
     ENSP00000371790  
    Reactome Protein details: P31371
    Human Recombinant Protein Products for FGF9: 
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    Sino Biological Recombinant Protein for FGF9
    Sino Biological Cell Lysate for FGF9 
    ProSpec Recombinant Protein for FGF9
    Cloud-Clone Corp. Proteins for FGF9 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA8321227
    GO:0005737cytoplasm IEA--

    FGF9 for ontologies           About GeneDecksing



    FGF9 Antibody Products: 
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    Assay Products for FGF9: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF9 
    Cloud-Clone Corp. CLIAs for FGF9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry P31371

    ProtoNet protein and cluster: P31371

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371
    Similarity: Belongs to the heparin-binding growth factors family


    FGF9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF9_HUMAN, P31371
    Function: Plays an important role in the regulation of embryonic development, cell proliferation, cell
    differentiation and cell migration. May have a role in glial cell growth and differentiation during development,
    gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal
    cells, and growth stimulation of glial tumors

         Genatlas biochemistry entry for FGF9:
    fibroblast growth factor 9

         Summary:
    During embryonic development, FGF9 as signaling molecule is secreted from the following cells: Ectoderm Cells in Branchial Arch 1, Endochondral Preosteoblasts in Zeugopod Perichondrium (see all 10).

    It affects the following cells: Cardiomyocytes in Myocardium, Cranial Neural Crest Cells in Branchial Arch 1 (see all 16).

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IEA--
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--
         
    FGF9 for ontologies           About GeneDecksing


    Phenotypes:
         15/18 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Fgf9) (see all 18):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  muscle  normal  reproductive system 

    FGF9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FGF9: Fgf9tm1.2Fwan Fgf9tm1Dor

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FGF9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FGF9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF9 

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    SwitchGear 3'UTR luciferase reporter plasmidFGF9 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FGF9 About   (see all 21)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2Development FGF-family signaling
    Development FGF-family signaling0.63
    FGF Pathway0.38
    3FGFR2c ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR1c ligand binding and activation0.79
    SHC-mediated cascade0.79
    FGFR2 ligand binding and activation0.76
    FGFR2c ligand binding and activation0.79
    Signaling by FGFR2 mutants0.76
    FGFR1 ligand binding and activation0.79
    Activated point mutants of FGFR20.76
    4Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    5PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI-3K cascade0.88
    Signaling by SCF-KIT0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FGF9
        Development FGF-family signaling

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF9
        P2Y Receptor Signaling
    FGF Pathway
    RhoGDI Pathway
    Regulation of eIF4 and p70S6K
    SOCS Pathway

    1 GeneGo (Thomson Reuters) Pathway for FGF9
        Development FGF-family signaling

    1 BioSystems Pathway for FGF9
        Regulation of Actin Cytoskeleton


    5/59        Reactome Pathways for FGF9 (see all 59)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    5/6         Kegg Pathways  (Kegg details for FGF9) (see all 6):
        MAPK signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Proteoglycans in cancer


    FGF9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/21 Interacting proteins for FGF9 (P313713 ENSP000003717904) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR4P224553, ENSP000002924084I2D: score=1 STRING: ENSP00000292408
    FGFR3P226073, ENSP000002607954I2D: score=2 STRING: ENSP00000260795
    FGF1ENSP000003385484STRING: ENSP00000338548
    FGF10ENSP000002646644STRING: ENSP00000264664
    FGF18ENSP000002746254STRING: ENSP00000274625
    About this table

    Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001649osteoblast differentiation IEA--
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0002062chondrocyte differentiation IEA--
    GO:0006606protein import into nucleus IEA--

    FGF9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF9

    7 Novoseek inferred chemical compound relationships for FGF9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 35.1 2 16452189 (1)
    heparin 26.8 2 15058010 (1), 12820388 (1)
    vegf 22.2 5 17082335 (2), 16377203 (1), 14872006 (1), 17881491 (1)
    calcium 0 2 18093889 (3), 18978176 (2), 15760907 (1)
    tyrosine 0 3 18336810 (1)
    methionine 0 2 9139882 (1), 8321227 (1)
    estrogen 0 4 14602803 (4)

    Search CenterWatch for drugs/clinical trials and news about FGF9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FGF9 gene: 
    NM_002010.2  

    Unigene Cluster for FGF9:

    Fibroblast growth factor 9 (glia-activating factor)
    Hs.111  [show with all ESTs]
    Unigene Representative Sequence: NM_002010
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382353(uc001uog.2) ENST00000461657 ENST00000478546
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    hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-520e hsa-miR-376b hsa-miR-15a hsa-miR-485-3p
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    Additional mRNA sequence: 

    AK095571.1 AK290792.1 BC069692.1 BC103978.1 BC103979.1 D14838.1 

    4 DOTS entries:

    DT.206299  DT.65284556  DT.102823820  DT.75182799 

    24/38 AceView cDNA sequences (see all 38):

    AI221350 BM724935 BX402882 BX110535 AI765602 AI078616 CD613709 CD613707 
    NM_002010 AL583692 BM680164 BM720010 AI334161 AA989402 BI827161 BX282365 
    AI963033 BM926135 AI798776 D14838 AW466928 AK095571 BC069692 BF942066 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FGF9    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b
    SP1:                    -               
    SP2:                                    


    ECgene alternative splicing isoforms for FGF9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF9 expression in normal human tissues (normalized intensities)      FGF9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGAAAAAA
    FGF9 Expression
    About this image


    FGF9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 19 entries
             Endochondral Preosteoblasts Stylopod Perichondrium
             Membranous Facial Bones
             Bone marrow-derived mesenchymal stem cells
             sensory organ/ear/inner ear   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
             limb/hindlimb   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Retina
             sensory organ/eye/cornea   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Epicardial Progenitors Cells Epicardium
             heart/ventricle   

    See FGF9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF9

    SOURCE GeneReport for Unigene cluster: Hs.111

    UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371
    Tissue specificity: Glial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF9: 
              Growth Factors in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Targets in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FGF9 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf91 , 5 fibroblast growth factor 91, 5 92.47(n)1
    99.52(a)1
      14 (30.51 cM)5
    141801  NM_013518.41  NP_038546.21 
     580705475 
    chicken
    (Gallus gallus)
    Aves FGF91 fibroblast growth factor 9 (glia-activating factor) 89.1(n)
    97.6(a)
      378917  NM_204399.1  NP_989730.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF96
    Uncharacterized protein
    93(a)
    1 ↔ 1
    3(188009617-188056526)
    African clawed frog
    (Xenopus laevis)
    Amphibia fgf9-A2 fibroblast growth factor 9 (glia-activating factor) 84.23(n)    U47622.1 


    ENSEMBL Gene Tree for FGF9 (if available)
    TreeFam Gene Tree for FGF9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF9 gene
    FGF122  FGF162  FGF52  FGF202  FGF42  FGF62  FGF32  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    15 SIMAP similar genes for FGF9 using alignment to 1 protein entry:     FGF9_HUMAN:
    FGF20    FGF16    FGF10    FGF12    FGF7    FGF22
    FGF13    FGF1    FGF11    FGF14    FGF6    FGF3
    FGF5    FGF4    FGF2

    FGF9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/666 SNPs in FGF9 are shown (see all 666)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0632544
    Multiple synostoses syndrome 3 (SYNS3)4--see VAR_0632542 S N mis40--------
    rs106242651,2
    C--3047547(+) TTTTT-/T/TT  
            
    CTCTC
    2 -- ut51 trp31CSA 2
    rs1905925761,2
    --3197422(+) CCTGTA/CTCTGT 1 -- us2k10--------
    rs749256641,2
    F--3197560(+) TTTATG/TAGAAG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs18868611,2
    C,F,A,H--3197575(+) ACTTAA/CTACCC 1 -- us2k122Minor allele frequency- C:0.33NS EA NA CSA WA 2528
    rs1122654361,2
    C,F--3197621(+) AAGCCC/TGCTCT 1 -- us2k13Minor allele frequency- T:0.05CSA WA 122
    rs1483696421,2
    C--3197634(+) ACCACC/GGCGGA 1 -- us2k10--------
    rs2021815271,2
    C--3197746(+) GCAAA-/GGGGGG 1 -- us2k10--------
    rs1415780541,2
    --3197749(+) AAAGGG/TGGGGT 1 -- us2k10--------
    rs1925079671,2
    --3197812(+) GGGCCA/GGAGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FGF9 (22245215 - 22278640 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FGF9:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509497CNV Insertion20534489
    nsv832560CNV Loss17160897
    nsv899879CNV Gain21882294


    Human Gene Mutation Database (HGMD): FGF9
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF9
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600921   
    OMIM disorders: 612961  
    UniProtKB/Swiss-Prot: FGF9_HUMAN, P31371
  • Multiple synostoses syndrome 3 (SYNS3) [MIM:612961]: A bone disease characterized by multiple progressive
    joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine
    joints. Additional features can include progressive conductive deafness and facial dysmorphism. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 20/36 diseases for FGF9 (see all 36):    About MalaCards
    cystic adenomatoid malformation of lung    synovial chondromatosis    multiple synostoses syndrome 3    moebius syndrome
    melanoma of soft part    clouston syndrome    ladd syndrome    craniosynostosis, syndromic
    thanatophoric dysplasia    craniosynostosis    osteochondroma    achondroplasia
    skeletal dysplasias    lung adenocarcinoma    mood disorder    cleft lip
    endometriosis    teratocarcinoma    neuroendocrine tumor    chondrosarcoma

    1 disease from the University of Copenhagen DISEASES database for FGF9:
    Achondroplasia

    FGF9 for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for FGF9 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian endometrioid adenocarcinoma 72.4 1 16452189 (1)
    craniosynostosis 48.7 2 14613973 (1)
    glioma 35.5 15 9864407 (3), 9696088 (2), 9139882 (1), 8321227 (1) (see all 7)
    neoplastic transformation 20.3 2 16452189 (1)
    nsclc 6.51 6 18849352 (4), 19358281 (1)
    glioblastoma 5.8 4 9696088 (1), 9507114 (1)
    endometriosis 4.16 3 14602803 (1), 16982695 (1)
    hypertrophy 0 1 17544391 (1)
    brain tumors 0 5 9696088 (4)
    tumors 0 18 9696088 (3), 18165946 (3), 9139882 (2), 16452189 (1) (see all 8)

    Genetic Association Database (GAD): FGF9
    Human Genome Epidemiology (HuGE) Navigator: FGF9 (6 documents)

    Export disorders for FGF9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF9 gene, integrated from 9 sources (see all 160):
    (articles sorted by number of sources associating them with FGF9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. (PubMed id 8321227)1, 2, 3, 9 Miyamoto M.... Kurokawa T. (1993)
    2. Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. (PubMed id 11060292)1, 2, 9 Plotnikov A.N....Mohammadi M. (2001)
    3. Multiple synostoses syndrome is due to a missense mut ation in exon 2 of FGF9 gene. (PubMed id 19589401)1, 2, 9 Wu X.L....Wang Z.G. (2009)
    4. Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces. (PubMed id 11223514)1, 2, 9 Hecht H.J.... Yayon A. (2001)
    5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    6. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    7. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    8. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 2 Zhang X....Ornitz D.M. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2254 HGNC: 3687 AceView: FGF9 Ensembl:ENSG00000102678 euGenes: HUgn2254
    ECgene: FGF9 Kegg: 2254 H-InvDB: FGF9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF9 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: FGF-9http://www.rndsystems.com/molecule_detail.aspx?m=1436
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FGF9 gene:
    Search GeneIP for patents involving FGF9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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