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FGF8 Gene

protein-coding   GIFtS: 68
GCID: GC10M103530

Fibroblast Growth Factor 8 (Androgen-Induced)

  See FGF8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 8 (Androgen-Induced)1 2     HBGF-82 3
Androgen-Induced Growth Factor2 3     HH62 5
Heparin-Binding Growth Factor 82 3     KAL62
AIGF2 3     Fibroblast Growth Factor 82
FGF-82 3     

External Ids:    HGNC: 36861   Entrez Gene: 22532   Ensembl: ENSG000001078317   OMIM: 6004835   UniProtKB: P550753   

Export aliases for FGF8 gene to outside databases

Previous GC identifers: GC10M102423 GC10M102763 GC10M103661 GC10M103194 GC10M103519 GC10M097160


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF8 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This
protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells.
Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this
gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its
function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain
and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative
splicing of this gene results in four transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF8 Gene:
FGF8 (fibroblast growth factor 8 (androgen-induced)) is a protein-coding gene. Diseases associated with FGF8 include septopreoptic holoprosencephaly, and midline interhemispheric variant of holoprosencephaly. GO annotations related to this gene include growth factor activity and type 1 fibroblast growth factor receptor binding. An important paralog of this gene is FGF17.

UniProtKB/Swiss-Prot: FGF8_HUMAN, P55075
Function: Plays an important role in the regulation of embryonic development, cell proliferation, cell
differentiation and cell migration. Required for normal brain, eye, ear and limb development during
embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system

Gene Wiki entry for FGF8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF8 gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF8 promoter sequence
   Search Chromatin IP Primers for FGF8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q25-q26

FGF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M103530:  view genomic region     (about GC identifiers)

Start:
103,529,887 bp from pter      End:
103,540,126 bp from pter
Size:
10,240 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FGF8_HUMAN, P55075 (See protein sequence)
Recommended Name: Fibroblast growth factor 8 precursor  
Size: 233 amino acids; 26525 Da
Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth
factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as
coreceptors
Developmental stage: In adults expression is restricted to the gonads
1 PDB 3D structure from and Proteopedia for FGF8:
2FDB (3D)    
Secondary accessions: A1A514 Q14915 Q15766
Alternative splicing: 4 isoforms:  P55075-1   P55075-2   P55075-3   P55075-4   

Explore the universe of human proteins at neXtProt for FGF8: NX_P55075

Explore proteomics data for FGF8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn155

  • See FGF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001193318.1  NP_006110.1  NP_149353.1  NP_149354.1  NP_149355.1  

    ENSEMBL proteins: 
     ENSP00000473299   ENSP00000340039   ENSP00000321797   ENSP00000344306   ENSP00000321945  
    Reactome Protein details: P55075

    FGF8 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant FGF8 Protein
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    OriGene Protein Over-expression Lysate for FGF8
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    GenScript Purified and Recombinant Proteins for FGF8
    Novus Biologicals FGF8 Proteins
    Novus Biologicals FGF8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FGF8
    Cloud-Clone Corp. Proteins for FGF8

     
    Search eBioscience for Proteins for FGF8 

    FGF8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FGF8 (FGF-8)
    OriGene Antibodies for FGF8
    OriGene Custom Antibody Services for FGF8
    Novus Biologicals FGF8 Antibodies
    Abcam antibodies for FGF8 (P55075, A1A515)
    Cloud-Clone Corp. Antibodies for FGF8
    Search ThermoFisher Antibodies for FGF8
    LSBio Antibodies in human, mouse, rat for FGF8

    FGF8 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF8
    Cloud-Clone Corp. CLIAs for FGF8
    Search eBioscience for ELISAs for FGF8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam
     IPR028249 FGF8

    Graphical View of Domain Structure for InterPro Entry P55075

    ProtoNet protein and cluster: P55075

    1 Blocks protein domain: IPB002348 IL1/HBGF family signature

    UniProtKB/Swiss-Prot: FGF8_HUMAN, P55075
    Similarity: Belongs to the heparin-binding growth factors family


    Find genes that share domains with FGF8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF8_HUMAN, P55075
    Function: Plays an important role in the regulation of embryonic development, cell proliferation, cell
    differentiation and cell migration. Required for normal brain, eye, ear and limb development during
    embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system

         Genatlas biochemistry entry for FGF8:
    fibroblast growth factor 8,involved in the development of the central nervous system,face,limbs,(key indicator of
    apical ectodermal ridge,AER) kidney in mouse,unlikely involved in craniosynostosis/limb defect syndromes

         Summary: 
    During embryonic development, FGF8 as signaling molecule is secreted from the following cells:
          selected tissues (see all 9)      fully expand
    Surface Ectoderm: Surface Ectoderm Cells (Surface Ectoderm), Maxillary Ectoderm Cells (Surface Ectoderm)      fully expand to see all 3 cells
    Neural Ectoderm: Isthmus Cells (Neural Plate), Anterior Neural Ridge Cells (Neural Plate)      fully expand to see all 2 cells

    It affects the following cells:
          selected tissues (see all 12)      fully expand
    Head Mesenchyme: Mesencephalic Neural Crest Cells (Branchial Arch 1), Cranial Neural Crest Cells (Branchial Arch 1)      fully expand to see all 3 cells
    Neural Tube: Dorsolateral Hinge Point Cells (Mesencephalon), Meso-diencephalic Dopaminergic Precursor Cells (Diencephalic Floor Plate)      fully expand to see all 5 cells

    FGF8 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 3)      fully expand
    Brain: N2/LSB/S/F8/CHIR-induced cells, Dopaminergic-like neurons      fully expand to see all 4 cells
    Neurons: Dopaminergic-like neurons, Dopamine-releasing cells       fully expand to see all 2 cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IEA--
    GO:0005105type 1 fibroblast growth factor receptor binding IDA16384934
    GO:0005111type 2 fibroblast growth factor receptor binding IDA16384934
    GO:0008083growth factor activity IEA--
    GO:0042056chemoattractant activity IEA--
         
    Find genes that share ontologies with FGF8           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 14 alleles(MGI details for Fgf8) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  mortality/aging  muscle 

    Find genes that share phenotypes with FGF8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FGF8: Fgf8tm1.4Mrt Fgf8tm1.2Mrt Fgf8tm1Mrc Fgf8tm2.1Jyhl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF8

    miRNA
    Products:
        
    miRTarBase miRNAs that target FGF8:
    hsa-mir-335-5p (MIRT017212)

    Block miRNA regulation of human, mouse, rat FGF8 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate FGF8:
    hsa-miR-548d-3p hsa-miR-3120-3p hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmidFGF8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FGF8
    Predesigned siRNA for gene silencing in human, mouse, rat FGF8

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for FGF8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): FGF8 (NM_033164)
    Sino Biological Human cDNA Clone for FGF8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF8

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FGF8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF8_HUMAN, P55075: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytoskeleton1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA8891346
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with FGF8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF8 About   (see all 34)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR4 ligand binding and activation0.00
    SHC-mediated cascade0.79
    FGFR1 ligand binding and activation0.00
    FGFR2 ligand binding and activation0.74
    Activated point mutants of FGFR20.00
    FRS2-mediated cascade0.70
    Signaling by FGFR2 mutants0.00
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82


    Find genes that share SuperPaths with FGF8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF8 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF8
        Development FGF-family signaling

    3 BioSystems Pathways for FGF8
        Heart Development
    Neural Crest Differentiation
    Regulation of Actin Cytoskeleton


    Selected Reactome Pathways for FGF8 (see all 18)
        Signaling by activated point mutants of FGFR1
    FRS2-mediated cascade
    FGFR4 ligand binding and activation
    Negative regulation of FGFR signaling
    Activated point mutants of FGFR2


    Selected Kegg Pathways  (Kegg details for FGF8) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FGF8
    Interactions:

        GeneGlobe Interaction Network for FGF8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for FGF8 (P550753 ENSP000003217974) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR4P224553, ENSP000002924084I2D: score=1 STRING: ENSP00000292408
    FGFR3P226073, ENSP000002607954I2D: score=2 STRING: ENSP00000260795
    FGFR2ENSP000004102944STRING: ENSP00000410294
    FGFR1ENSP000003802804STRING: ENSP00000380280
    EGFRENSP000002754934STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 77):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IEA--
    GO:0001569patterning of blood vessels IEA--
    GO:0001656metanephros development IEP18437684
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001759organ induction IEA--

    Find genes that share ontologies with FGF8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF8

    1 HMDB Compound for FGF8    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    Selected Novoseek inferred chemical compound relationships for FGF8 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 48.4 25 10872810 (4), 11144352 (2), 17600781 (2), 15069081 (1) (see all 14)
    retinoid 33.3 1 11526081 (1)
    tyrosine 24.8 10 16399079 (2), 11312556 (1), 17085092 (1), 15917474 (1) (see all 5)
    dopamine 16.2 9 15917474 (2), 11312556 (1), 17085092 (1), 18691653 (1) (see all 7)
    vitamin a 7.77 2 9004130 (1)
    heparan sulfate 7.75 2 17493930 (1), 12077148 (1)
    testosterone 4.55 38 16252261 (7), 12140757 (4), 7632608 (3), 9777371 (3) (see all 7)
    suramin 4.2 2 7829396 (1)
    forskolin 1.27 4 15193767 (2), 15245752 (1), 19627448 (1)
    ibmx 0.184 1 15725745 (1)



    Find genes that share compounds with FGF8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGF8 gene (5 alternative transcripts): 
    NM_001206389.1  NM_006119.4  NM_033163.3  NM_033164.3  NM_033165.3  

    Unigene Cluster for FGF8:

    Fibroblast growth factor 8 (androgen-induced)
    Hs.57710  [show with all ESTs]
    Unigene Representative Sequence: NM_033163
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469792 ENST00000344255 ENST00000485728 ENST00000320185(uc001ktp.2 uc001ktq.2)
    ENST00000346714(uc021pxg.1) ENST00000347978(uc001ktr.2 uc001kts.2 uc009xwr.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat FGF8 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate FGF8:
    hsa-miR-548d-3p hsa-miR-3120-3p hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmidFGF8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FGF8
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    GenScript: all cDNA clones in your preferred vector (see all 5): FGF8 (NM_033164)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF8
    Primer
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    OriGene qPCR primer pairs and template standards for FGF8
    OriGene qSTAR qPCR primer pairs in human, mouse for FGF8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF8
      QuantiTect SYBR Green Assays in human, mouse, rat FGF8
      QuantiFast Probe-based Assays in human, mouse, rat FGF8

    Additional mRNA sequence: 

    AB014615.1 BC069106.1 BC128235.1 BC128236.1 U36223.1 U46211.1 U46212.1 U46213.1 
    U46214.1 

    4 DOTS entries:

    DT.456212  DT.92415929  DT.100020014  DT.92415927 

    14 AceView cDNA sequences:

    BX281460 NM_006119 U46211 BC069106 U46213 NM_033163 NM_033164 U46212 
    NM_033165 AB014615 U36223 U56978 BG115475 U46214 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FGF8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                                                
    SP2:                    -                           
    SP3:        -     -                                 
    SP4:              -     -                           
    SP5:              -                                 


    ECgene alternative splicing isoforms for FGF8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FGF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCGGCTGC
    FGF8 Expression
    About this image


    FGF8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 29) fully expand
     
     Ectoderm (Gastrulation Derivatives)    fully expand to see all 4 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
             Limb Bud
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Isthmus Cells Neural Plate
             Mesencephalic Ventricular Zone
             Floor plate-like cells
     
     Surface Ectoderm (Integumentary System)    fully expand to see all 2 entries
             Surface Ectoderm Cells Surface Ectoderm
             Surface Ectoderm
     
     Kidney (Urinary System)    fully expand to see all 6 entries
             Distal Renal Vesicle Cells Renal Vesicle
             Metanephros
    FGF8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.57710
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF8 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf81 , 5 fibroblast growth factor 81, 5 94.81(n)1
    98.36(a)1
      19 (38.75 cM)5
    141791  NM_001166361.11  NP_001159833.11 
     457367985 
    chicken
    (Gallus gallus)
    Aves FGF81 fibroblast growth factor 8 (androgen-induced) 82.29(n)
    84.37(a)
      396313  NM_001012767.1  NP_001012785.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF86
    fibroblast growth factor 8 (androgen-induced)
    79(a)
    1 ↔ 1
    GL343239.1(1252702-1278083)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.200112 X.laevis mRNA for fibroblast growth factor 8, partial 79.79(n)    AF461177.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf82 fibroblast growth factor 8 80.08(n)   30538  AF051365.1 


    ENSEMBL Gene Tree for FGF8 (if available)
    TreeFam Gene Tree for FGF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF8 gene
    FGF172  FGF182  
    8 SIMAP similar genes for FGF8 using alignment to 3 protein entries:     FGF8_HUMAN (see all proteins):
    FGF17    FGF18    FGF7    KGFLP2    PRED3    KGFLP1
    FGF2    FGF11

    Find genes that share paralogs with FGF8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF8 (see all 184)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378526601,2,,4
    CHypogonadotropic hypogonadism 6 with or without anosmia (HH6)4 pathogenic1103534966(-) AGGCCC/TGGGCA 7 P L mis1 int10--------
    VAR_0579674
    Hypogonadotropic hypogonadism 6 with or without anosmia (HH6)4--see VAR_0579672 T M mis40--------
    VAR_0579644
    Hypogonadotropic hypogonadism 6 with or without anosmia (HH6)4--see VAR_0579642 F L mis40--------
    VAR_0579624
    Hypogonadotropic hypogonadism 6 with or without anosmia (HH6)4--see VAR_0579622 H N mis40--------
    VAR_0579654
    Hypogonadotropic hypogonadism 6 with or without anosmia (HH6)4--see VAR_0579652 K E mis40--------
    VAR_0579664
    Hypogonadotropic hypogonadism 6 with or without anosmia (HH6)4--see VAR_0579662 R G mis40--------
    rs1378526641,2
    Cunknown1103530135(-) CTTCAC/TGCGCA 10 T M mis10--------
    rs3747144101,2
    C--103529440(+) GGGGAA/TGGTTG 5 -- ds50010--------
    rs1473550291,2
    --103529560(+) CCCCGA/GCAGGA 5 -- ds50010--------
    rs1394990641,2
    --103529809(+) ATCCCA/TGTCTA 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGF8 (103529887 - 103540126 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FGF8:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv171n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): FGF8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF8
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600483   
    OMIM disorders: 612702  
    UniProtKB/Swiss-Prot: FGF8_HUMAN, P55075
  • Hypogonadotropic hypogonadism 6 with or without anosmia (HH6) [MIM:612702]: A disorder characterized by
    absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating
    gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it
    is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss.
    Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is
    due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of
    gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic
    hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been
    termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations
    affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic
    hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients
    carrying mutations in FGF8 as well as in other HH-associated genes including FGFR1 (PubMed:23643382)

  • 18 diseases for FGF8:    
    About MalaCards
    septopreoptic holoprosencephaly    midline interhemispheric variant of holoprosencephaly    fgf8-related isolated gonadotropin-releasing hormone deficiency    hypogonadotropic hypogonadism 6 with or without anosmia
    prostatic hypertrophy    lobar holoprosencephaly    alobar holoprosencephaly    single median maxillary central incisor
    hypogonadotropic hypogonadism 17 with or without anosmia    hypogonadotropic hypogonadism 8 with or without anosmia    semilobar holoprosencephaly    kallmann syndrome
    teratocarcinoma    split foot    hypospadias    split hand
    septo-optic dysplasia    prostate cancer

    6 diseases from the University of Copenhagen DISEASES database for FGF8:
    Klinefelter's syndrome     Hypogonadism     Syndactyly     Holoprosencephaly
    Parkinson's disease     Polydactyly

    Find genes that share disorders with FGF8           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FGF8 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    caronte 82.7 1 10882519 (1)
    kallmann syndrome 57.8 1 20363464 (1), 18987492 (1)
    pfeiffer syndrome 55.8 2 9332670 (1)
    prostate cancer 41.7 72 11406643 (8), 18386787 (7), 10348350 (4), 10629559 (4) (see all 24)
    teratocarcinoma 39.3 3 11764380 (1), 9366493 (1), 12820388 (1)
    mammary tumor 36.5 13 9784427 (2), 16252261 (2), 8738604 (1), 15897591 (1) (see all 6)
    parkinson disease 34.6 3 17640353 (1), 11532426 (1)
    holoprosencephaly 34.4 1 18173302 (1)
    craniosynostosis 32 5 9332670 (2), 8595889 (1)
    prostatic intraepithelial neoplasia 28.5 1 11406643 (1)

    GeneTests: FGF8
    GeneReviews: FGF8
    Genetic Association Database (GAD): FGF8
    Human Genome Epidemiology (HuGE) Navigator: FGF8 (4 documents)

    Export disorders for FGF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF8 gene, integrated from 10 sources (see all 300):
    (articles sorted by number of sources associating them with FGF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells. (PubMed id 8700553)1, 2, 9 Payson R.A.... Chiu I.-M. (Oncogene 1996)
    2. Molecular cloning and characterization of human FGF8 alternative messenger RNA forms. (PubMed id 8891346)1, 2, 9 Ghosh A.K.... Roy-Burman P. (Cell Growth Differ. 1996)
    3. FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias. (PubMed id 17264867)1, 4, 9 Beleza-Meireles A....NordenskjAPld A. (Eur. J. Hum. Genet. 2007)
    4. Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region. (PubMed id 8595889)1, 3, 9 White R.A....MacArthur C.A. (Genomics 1995)
    5. Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. (PubMed id 18596921)1, 2, 9 Falardeau J.... Pitteloud N. (J. Clin. Invest. 2008)
    6. Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. (PubMed id 16384934)1, 2, 9 Olsen S.K.... Mohammadi M. (Genes Dev. 2006)
    7. Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties. (PubMed id 7737407)1, 2, 9 Tanaka A.... Yoshida H. (FEBS Lett. 1995)
    8. Structure and sequence of human FGF8. (PubMed id 8661131)1, 2, 9 Gemel J.... Macarthur C.A. (Genomics 1996)
    9. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    10. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 2 Zhang X....Ornitz D.M. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2253 HGNC: 3686 AceView: FGF8 Ensembl:ENSG00000107831 euGenes: HUgn2253
    ECgene: FGF8 Kegg: 2253 H-InvDB: FGF8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGF8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF8 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF8 gene:
    Search GeneIP for patents involving FGF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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