Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FGF7 Gene

protein-coding GIFtS: 67
GCID: GC15P049715

fibroblast growth factor 7

(Previous name: fibroblast growth factor 7 (keratinocyte growth factor)...)

Explore 81 diseases affiliated with
FGF7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fibroblast Growth Factor 7¹ ²		FGF-7² ³
KGF¹ ² ³		HBGF-7² ³
Heparin-Binding Growth Factor 7² ³		Fibroblast Growth Factor 7 (Keratinocyte Growth Factor)¹
Keratinocyte Growth Factor² ³

External Ids:	HGNC: 3685¹	Entrez Gene: 2252²	Ensembl: ENSG00000140285⁷	OMIM: 148180⁵	UniProtKB: P21781³

Export aliases for FGF7 gene to outside databases

Previous GC identifers: GC15P045272 GC15P042761 GC15P047294 GC15P047431 GC15P047502 GC15P026547

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF7:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess

broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including

embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent

epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not

in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis

of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781

Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell

differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major

paracrine effector of normal epithelial cell proliferation

Gene Wiki entry for FGF7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FGF7 gene promoter:
C/EBPbeta AP-1 ATF-2 FOXD1 HNF-3beta C/EBPalpha STAT3 c-Jun Msx-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGF7 promoter sequence

Search SABiosciences Chromatin IP Primers for FGF7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2 Ensembl cytogenetic band: 15q21.2 HGNC cytogenetic band: 15q21.2

FGF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF7 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P049715: view genomic region (about GC identifiers)

Start:	49,715,293 bp from pter	End:	50,149,346 bp from pter
Size:	434,054 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781 (See protein sequence)

Recommended Name: Fibroblast growth factor 7 precursor

Size: 194 amino acids; 22509 Da

Subunit: Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their

receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors

Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for FGF7: NX_P21781

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P21781

FGF7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002000.1

ENSEMBL proteins:

ENSP00000267843 ENSP00000454205 ENSP00000453048 ENSP00000453980

Reactome Protein details: P21781
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant FGF7 Protein
	R&D Systems Recombinant & Natural Proteins for FGF7 (KGF/FGF-7)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): FGF7 OriGene Protein Over-expression Lysate: FGF7 OriGene Custom Protein Services for FGF7
	GenScript Purified and Recombinant Proteins for FGF7
	Novus Biologicals FGF7 Proteins Novus Biologicals FGF7 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for FGF7
	Uscn Proteins for FGF7

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	--	--
GO:0005794	Golgi apparatus	IEA	--

FGF7 for ontologies About GeneDecksing

FGF7 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for FGF7 (KGF/FGF-7)
	OriGene Antibodies: FGF7 OriGene Custom Antibody Services for FGF7
	GenScript Custom Superior Antibodies Services for FGF7
	Novus Biologicals FGF7 Antibodies
	Abcam antibodies for FGF7
	Uscn Antibodies for FGF7
	ThermoFisher Antibodies for FGF7

Assay Products for FGF7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for FGF7 (KGF/FGF-7) (see all)
	GenScript Custom Assay Services for FGF7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FGF7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FGF7 for domains About GeneDecksing

3 InterPro domains/families:

IPR002348 IL1_HBGF

IPR008996 Cytokine_IL1-like

IPR002209 GF_heparin-bd

Graphical View of Domain Structure for InterPro Entry P21781

ProtoNet protein and cluster: P21781

2 Blocks protein families:

IPB002209 Heparin binding growth factor family signature

IPB002348 IL1/HBGF family signature

UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781

Similarity: Belongs to the heparin-binding growth factors family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781

Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell

differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major

paracrine effector of normal epithelial cell proliferation

Genatlas biochemistry entry for FGF7:

fibroblast growth factor 7,expressed in epithelial tissues,including corneal and mammary epithelial cells,mitogenic for

epithelial cells

Summary:

During embryonic development, FGF7 as signaling molecule is secreted from the following cells: Metanephric Mesenchyme Cells in Metanephric Mesenchyme It affects the following cells: Multipotent Lung Progenitor Cells in Ventral Foregut Endoderm

FGF7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Posterior foregut endoderm, Immature proximal lung cells (see all 11).

miRNA Products:		miRTarBase miRNAs that target FGF7: hsa-mir-155 (MIRT003482)

		OriGene 3'-UTR Clone: FGF7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF7
		8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF7 (see all 83):
		hsa-miR-582-3p hsa-miR-361-5p hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-199a-3p hsa-miR-632 hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: FGF7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF7 (see all 6) OriGene siRNA: FGF7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF7

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FGF7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FGF7 (NM_002009)
		Sino Biological Human cDNA Clone for FGF7
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FGF7
		Search LifeMap BioReagents cell lines for FGF7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF7

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005111	type 2 fibroblast growth factor receptor binding	--	--
GO:0005515	protein binding	IPI	1309608
GO:0008083	growth factor activity	IEA	--
GO:0008201	heparin binding	IEA	--
GO:0042056	chemoattractant activity	IDA	17449030

FGF7 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FGF7:

Decreased viability with pacli

Animal Models:
Mouse knock-out Fgf7^tm1Efu for FGF7
8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fgf7):

behavior/neurological	hematopoietic system	homeostasis/metabolism	immune system	integument
nervous system	renal/urinary system	reproductive system

FGF7 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58	P2Y Receptor Signaling	0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FGF7

Development FGF-family signaling

5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF7 (see all 59)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 GeneGo (Thomson Reuters) Pathway for FGF7

Development FGF-family signaling

2 BioSystems Pathways for FGF7

	Regulation of Actin Cytoskeleton
	Glypican 3 network

5/48 Reactome Pathways for FGF7 (see all 48)

	FGFR2 ligand binding and activation
	FGFR ligand binding and activation
	Signaling by EGFR in Cancer
	Signaling by FGFR2 mutants
	Downstream signal transduction

4 Kegg Pathways (Kegg details for FGF7):

	MAPK signaling pathway
	Regulation of actin cytoskeleton
	Pathways in cancer
	Melanoma

FGF7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FGF7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/30 Interacting proteins for FGF7 (P21781^{1, 3} ENSP00000267843⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FGFR2	P21802-3¹, ENSP00000410294⁴	EBI-3937699,EBI-6354683 I2D: score=1 STRING: ENSP00000410294
HSPG2	P98160³, ENSP00000363827⁴	I2D: score=2 STRING: ENSP00000363827
COL1A1	P02452³, ENSP00000225964⁴	I2D: score=1 STRING: ENSP00000225964
COL3A1	P02461³, ENSP00000304408⁴	I2D: score=1 STRING: ENSP00000304408
COL6A1	P12109³, ENSP00000355180⁴	I2D: score=1 STRING: ENSP00000355180

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001541	ovarian follicle development	--	--
GO:0006656	phosphatidylcholine biosynthetic process	--	--
GO:0007165	signal transduction	NAS	2475908
GO:0008284	positive regulation of cell proliferation	IGI	8663044
GO:0008286	insulin receptor signaling pathway	TAS	--

FGF7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FGF7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FGF7

1 HMDB Compound for FGF7 About this table

Compound	Synonyms	CAS #	PubMed Ids
Heparin	Arteven (see all 17)	9005-49-6	--

10/81 Novoseek chemical compound relationships for FGF7 gene (see all 81) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
palifermin	93.5	38	17059384 (2), 15681392 (1), 17103218 (1), 18708365 (1) (see all 24)
kepivance	85.8	1	15843784 (1)
vegf	53	61	17920582 (4), 19930634 (4), 18674742 (2), 14681639 (2) (see all 33)
heparan sulfate	47.1	22	19755711 (2), 11724555 (2), 16315317 (2), 9466688 (2) (see all 8)
heparin	44.7	112	10593896 (9), 8806707 (6), 9636026 (5), 8783184 (5) (see all 29)
bromodeoxyuridine	39.7	21	7658592 (2), 12947032 (1), 10329601 (1), 11076805 (1) (see all 12)
tyrosine	38.3	30	11286634 (2), 11757032 (2), 15672868 (2), 9692365 (2) (see all 18)
amifostine	37.1	2	12621500 (1), 15018311 (1)
thymidine	33.4	18	10691999 (2), 14695201 (1), 17593825 (1), 17953372 (1) (see all 12)
dextran sulfate sodium	32.1	2	17449036 (1), 16698153 (1)

Search CenterWatch for drugs/clinical trials and news about FGF7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FGF7 gene:

NM_002009.3

Unigene Cluster for FGF7:

Fibroblast growth factor 7

Hs.567268 [show with all ESTs]

Unigene Representative Sequence: NM_002009

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000267843(uc001zxn.3) ENST00000560270 ENST00000560765 ENST00000560979

ENST00000560704

miRNA Products:		OriGene 3'-UTR Clone: FGF7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF7
		8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF7 (see all 83):
		hsa-miR-582-3p hsa-miR-361-5p hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-199a-3p hsa-miR-632 hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: FGF7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF7 (see all 6) OriGene siRNA: FGF7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FGF7 (NM_002009)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FGF7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF7

Additional cDNA sequence:

AK313160.1 BC010956.1 CR542002.1 M60828.1 S81661.1

8 DOTS entries:

DT.211693 DT.95260045 DT.121049828 DT.121049830 DT.121049713 DT.121049744 DT.121049814 DT.121096587

24/67 AceView cDNA sequences (see all 67):

CR617541 AU280372 CR593889 AL703203 W79892 AL525382 BQ953882 BX094084

BX483338 CR609737 BU838527 BX328135 CD679601 CB998699 BI222235 BP379722

AL525342 S81661 BP335485 BP374851 BQ892377 BG571312 CD613700 BM685449

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FGF7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

FGF7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Choroid Plexus Progenitor Cells

Choroid Plexus

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

mK3 (Cell line)

Kidney

mK4 (Cell line)

Kidney

See FGF7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGF7

SOURCE GeneReport for Unigene cluster: Hs.567268

UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781

Tissue specificity: Epithelial cell

SABiosciences Expression via Pathway-Focused PCR Arrays including FGF7:

Growth Factors in human mouse rat

WNT Signaling Targets in human mouse rat

Wound Healing in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FGF7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FGF7 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FGF7¹	fibroblast growth factor 7	85.74(n) 82.99(a)		415439 NM_001012525.1 NP_001012543.1
lizard (Anolis carolinensis)	Reptilia	FGF7⁶	--	75(a)	1 ↔ 1	GL343506.1(157358-184607)
zebrafish (Danio rerio)	Actinopterygii	fgf7¹	fibroblast growth factor 7	60.99(n) 58.16(a)		493181 NM_001007761.1 NP_001007762.1
worm (Caenorhabditis elegans)	Secernentea	let-756⁶	Protein let-756	12(a)	1 → many	III(6407076-6409965)

ENSEMBL Gene Tree for FGF7 (if available)
TreeFam Gene Tree for FGF7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FGF7 gene

FGF12² FGF5² FGF20² FGF16² FGF4² FGF9² FGF6² FGF3²

FGF11² FGF10² FGF13² FGF22² FGF14²

18/19 SIMAP similar genes for FGF7 using alignment to 5 protein entries: FGF7_HUMAN (see all proteins) (see all similar genes):

KGFLP1 KGFLP2 PRED3 FGF10 FGF16 FGF22

FGF9 FGF20 FGF8 FGF5 FGF12 FGF13

FGF6 FGF11 FGF4 FGF3 FGF2 fgf gene

FGF7 for paralogs About GeneDecksing

5/8 Pseudogenes.org Pseudogenes for FGF7 (see all 8)
PGOHUM00000262128 PGOHUM00000239126 PGOHUM00000236072 PGOHUM00000236104 PGOHUM00000236144

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11638314^1,2	C,H,	--	26545850(+)	`ATTCTG/AAGCCT`	1	--	us2k¹		3		NA	124
rs12593068^1,2	C,F,H,	--	26546223(+)	`TCACAT/GAGAGA`	1	--	us2k¹		4		EA NS NA	278
rs112564276^1,2		--	26546284(+)	`GTGCAT/CGCGTG`	1	--	us2k¹		1		CSA	1
rs73398284^1,2	C,	--	26546304(+)	`AGGAGT/CATATA`	1	--	us2k¹		3		WA NA	240
rs12591052^1,2	H	--	26546354(+)	`ATTTAG/TATAGA`	1	--	us2k¹		0	--	--	--	--
rs73398286^1,2	C,	--	26547293(+)	`TGCTTC/TCAATG`	1	--	ut5¹		1		WA	2
rs77730249^1,2		--	26547873(+)	`TGCAGT/CATGGT`	1	--	int¹		1		WA	118
rs34531231^1,2	C,F	--	26548574(+)	`TTACAT/CGGAAG`	2	/T /M	mis¹		3		NA	70
rs73398287^1,2	C,	--	26549149(+)	`ACTTAA/TTCTGT`	1	--	int¹		2		WA	120
rs72727286^1,2		--	26549374(+)	`AAAAAA/GTGGGC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FGF7 (49715293 - 49965293 bp, first 250kb of FGF7)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FGF7
3 CNVs: 87685 72246 30712
1 Indel: 58725

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF7

DNA2.0 Custom Variant and Variant Library Synthesis for FGF7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FGF7 for disorders           About GeneDecksing

OMIM gene information: 148180    OMIM disorders: --

20/81 diseases for FGF7 (see all 81):    About MalaCards

graft versus host disease middle ear cholesteatoma cleft lip/palate chronic venous leg ulcers

oncogenic osteomalacia clear cell acanthoma gingival overgrowth congenital diaphragmatic hernia

dry eye syndrome short bowel syndrome pfeiffer syndrome bronchopulmonary dysplasia

acanthoma cleft lip inflammatory bowel disease bazex syndrome

hernia squamous cell carcinoma chronic obstructive pulmonary disease cholesteatoma

2 diseases from the University of Copenhagen DISEASES database for FGF7:

Cholesteatoma Cancer

10/81 Novoseek disease relationships for FGF7 gene (see all 81) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
stomatitis	67.8	15	11258848 (1), 18708365 (1), 15327889 (1), 12182998 (1) (see all 11)
mucositis	67.1	28	18560408 (4), 12139710 (3), 9422575 (2), 11045187 (1) (see all 18)
epithelial hyperplasia	54.5	9	12492503 (1), 7560096 (1), 9109075 (1), 7977634 (1) (see all 5)
benign prostatic hyperplasia	51.3	16	10411093 (3), 9285567 (1), 9844400 (1), 18386288 (1) (see all 11)
apert syndrome	48	2	11596961 (1), 14613973 (1)
hematologic malignancies	41.8	7	18708365 (1), 15327889 (1), 16499139 (1), 18632516 (1) (see all 7)
acute respiratory distress	39.9	6	10921560 (2), 19325470 (2), 16672636 (1)
hyperplasia	35.4	20	9788959 (3), 11076805 (2), 10766812 (2), 9256328 (1) (see all 13)
pfeiffer syndrome	35.2	1	14613973 (1)
respiratory distress syndrome	33.2	6	10921560 (2), 19325470 (2), 16672636 (1)

Human Genome Epidemiology (HuGE) Navigator: FGF7 (1 document)

Export disorders for FGF7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FGF7 gene, integrated from 9 sources (see all 726):
(articles sorted by number of sources associating them with FGF7)

Utopia: connect your pdf to the dynamic
world of online information

The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PubMed id 15806171)^{1, 2, 9} Beer H.-D....Werner S. (2005)
Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)^{1, 2} Ornitz D.M....Goldfarb M. (1996)
Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively. (PubMed id 7749227)^{1, 3} Mattei M.G....Mason I. (1995)
Emergence of the keratinocyte growth factor multigene family during the great ape radiation. (PubMed id 1409637)^{1, 3} Kelley M.J....Aaronson S.A. (1992)
Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. (PubMed id 1664700)^{1, 2} Aaronson S.A.... Rubin J.S. (1991)
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. (PubMed id 2475908)^{1, 2} Finch P.W.... Aaronson S.A. (1989)
Purification and characterization of a newly identified growth factor specific for epithelial cells. (PubMed id 2915979)^{1, 2} Rubin J.S....Aaronson S.A. (1989)
Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer. (PubMed id 11000522)^{1, 9} Parrott J.A....Skinner M.K. (2000)
Role of keratinocyte growth factor in the pathogenesis of autosomal dominant polycystic kidney disease. (PubMed id 16141466)^{1, 9} Mei C....Sun T. (2005)
Elevated expression of FGF7 protein is common in human gastric diseases. (PubMed id 17049492)^{1, 9} Shaoul R....Ron D. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2252	HGNC: 3685	AceView: FGF7	Ensembl:ENSG00000140285	euGenes: HUgn2252
ECgene: FGF7	Kegg: 2252	H-InvDB: FGF7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FGF7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FGF7	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FGF7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FGF7 gene:
Search GeneIP for patents involving FGF7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore Purified and/or Recombinant FGF7 Protein
	Browse Small Molecules at EMD Millipore
	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for FGF7 (KGF/FGF-7)		Browse Cell Culture Products
	ELISAs for FGF7 (KGF/FGF-7)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for FGF7 (KGF/FGF-7)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for FGF7 (KGF/FGF-7)

	OriGene Antibodies for FGF7		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF7		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF7
	OriGene Protein Over-expression Lysate for FGF7		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for FGF7		OriGene 3'-UTR Clone for FGF7
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF7		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF7
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for FGF7		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FGF7		OriGene Custom Protein Services for FGF7
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FGF7
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF7
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF7
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF7
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF7
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF7

	GenScript Purified and Recombinant Proteins for FGF7		GenScript cDNA clones with any tag delivered in your preferred vector for FGF7
	GenScript Custom Assay Services for FGF7		GenScript Custom Superior Antibodies Services for FGF7
	GenScript Custom overexpressing Cell Line Services for FGF7		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in FGF7 promoter
	Search Chromatin IP Primers for FGF7
	RT² qPCR Primer Assay in human, mouse, rat FGF7
	GNC Network for FGF7
	SABiosciences PCR Arrays including human, mouse, rat FGF7

Search Tocris compounds for FGF7

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for FGF7
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	FGF7 antibodies
	FGF7 proteins
	FGF7 lysates

	Antibodies for FGF7
	See all of Abcam's Antibodies, Kits and Proteins for FGF7
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for FGF7

FGF7 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for FGF7

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF7

	SwitchGear 3'UTR luciferase reporter plasmids for FGF7
	SwitchGear Promoter luciferase reporter plasmids for FGF7

ThermoFisher Antibodies for FGF7

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF7

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FGF7 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

FGF7 Gene

fibroblast growth factor 7

Aliases
for FGF7 gene

Summaries
for FGF7 gene

Genomic Views
for FGF7 gene

Proteins
for FGF7 gene

Protein Domains /
Families
for FGF7 gene

Function
for FGF7 gene

Pathways & Interactions
for FGF7 gene

Drugs & Compounds
for FGF7 gene

Transcripts
for FGF7 gene

Expression
for FGF7 gene

Orthologs
for FGF7 gene

Paralogs
for FGF7 gene

Genomic Variants
for FGF7 gene

Disorders / Diseases
for FGF7 gene

Publications
for FGF7 gene

External Searches for FGF7 gene

Genome Databases showing FGF7 gene

Other Databases showing FGF7 gene

Specialized Databases showing FGF7 gene

Intellectual Property
for FGF7 gene

Products
for FGF7 gene

View Random Gene

Cystic Fibrosis
dysplasia
Colitis Ulcerative
COLON CARCINOMA
Teratocarcinoma
Systemic Disease
Skin Diseases
Breast Cancer
Respiratory Distress Syndrome
Neovascularization
Edema
primary tumor
Adenocarcinoma
cell damage
Obstruction
Cancer
Bronchopulmonary Dysplasia
Lymphoma
Apert Syndrome
GASTRIC CARCINOMA
Ovarian Cancer
Nasal Polyps
Bronchoalveolar Lavage Fluid
Ulcer
Colorectal Cancer
Inflammation
Cysts
Psoriasis
Hypertrophy
ENDOMETRIAL CARCINOMA
Rheumatoid Arthritis
prostate cancer
Pneumonia
Tumors
Metastasis
Necrosis
OROPHARYNGEAL
Sarcoma
molecular pathology
FIBROSIS IDIOPATHIC PULMONARY
Gingival Hyperplasia
Colitis
Gastric Cancer
Melanoma
BREAST CARCINOMA
Epithelial hyperplasia
Pulmonary Fibrosis
Hyperplasia
Cholesteatoma
Carcinoma
PROSTATE CARCINOMA
epithelial tumor
Leukemia
Short Bowel Syndrome
CERVICAL CARCINOMA
Carcinoma Renal Cell
Pancreatic Cancer
Hematologic Malignancies
Cancer Lung
gastric ulcer
Inflammatory Bowel Diseases
Hernia Diaphragmatic
PULMONARY INFILTRATE
Pfeiffer Syndrome
Scar
benign prostatic hyperplasia
Bleeding
mucositis
solid tumor
Carcinoma Squamous Cell
Lung diseases
Histopathology
SKIN LESION
Atrophy
Acute respiratory distress
HERNIA DIAPHRAGMATIC CONGENITAL
bowel disease
Graft-Versus-Host Disease
Gingival Overgrowth
Stomatitis
Choriocarcinoma

Advanced Search

Export list of displayed genes

FGF7 Gene

fibroblast growth factor 7

Aliasesfor FGF7 gene

Summariesfor FGF7 gene

Genomic Viewsfor FGF7 gene

Proteinsfor FGF7 gene

Protein Domains /Familiesfor FGF7 gene

Functionfor FGF7 gene

Pathways & Interactionsfor FGF7 gene

Drugs & Compoundsfor FGF7 gene

Transcriptsfor FGF7 gene

Expression for FGF7 gene

Orthologsfor FGF7 gene

Paralogsfor FGF7 gene

Genomic Variantsfor FGF7 gene

Disorders / Diseasesfor FGF7 gene

Publicationsfor FGF7 gene

External Searches for FGF7 gene

Genome Databases showing FGF7 gene

Other Databases showing FGF7 gene

Specialized Databases showing FGF7 gene

Intellectual Propertyfor FGF7 gene

Productsfor FGF7 gene

View Random Gene

Aliases
for FGF7 gene

Summaries
for FGF7 gene

Genomic Views
for FGF7 gene

Proteins
for FGF7 gene

Protein Domains /
Families
for FGF7 gene

Function
for FGF7 gene

Pathways & Interactions
for FGF7 gene

Drugs & Compounds
for FGF7 gene

Transcripts
for FGF7 gene

Expression
for FGF7 gene

Orthologs
for FGF7 gene

Paralogs
for FGF7 gene

Genomic Variants
for FGF7 gene

Disorders / Diseases
for FGF7 gene

Publications
for FGF7 gene

Intellectual Property
for FGF7 gene

Products
for FGF7 gene