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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF7 Gene

protein-coding   GIFtS: 67
GCID: GC15P049715

fibroblast growth factor 7

(Previous name: fibroblast growth factor 7 (keratinocyte growth factor)...)
 Explore 81 diseases affiliated with
FGF7 via our new
 Human Malady Compendium 
Biological research products
for FGF7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fibroblast Growth Factor 71 2     FGF-72 3
KGF1 2 3     HBGF-72 3
Heparin-Binding Growth Factor 72 3     Fibroblast Growth Factor 7 (Keratinocyte Growth Factor)1
Keratinocyte Growth Factor2 3     

External Ids:    HGNC: 36851   Entrez Gene: 22522   Ensembl: ENSG000001402857   OMIM: 1481805   UniProtKB: P217813   

Export aliases for FGF7 gene to outside databases

Previous GC identifers: GC15P045272 GC15P042761 GC15P047294 GC15P047431 GC15P047502 GC15P026547


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF7:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess
broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including
embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent
epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not
in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis
of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781
Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell
differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major
paracrine effector of normal epithelial cell proliferation

Gene Wiki entry for FGF7


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF7 gene promoter:
         C/EBPbeta   AP-1   ATF-2   FOXD1   HNF-3beta   C/EBPalpha   STAT3   c-Jun   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF7 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

FGF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P049715:  view genomic region     (about GC identifiers)

Start:
49,715,293 bp from pter      End:
50,149,346 bp from pter
Size:
434,054 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781 (See protein sequence)
Recommended Name: Fibroblast growth factor 7 precursor  
Size: 194 amino acids; 22509 Da
Subunit: Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their
receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for FGF7: NX_P21781

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P21781

  • FGF7 Protein expression data from MOPED and PaxDb:    About this image 
    FGF7 Protein Expression
    REFSEQ proteins: NP_002000.1  
    ENSEMBL proteins: 
     ENSP00000267843   ENSP00000454205   ENSP00000453048   ENSP00000453980  
    Reactome Protein details: P21781
    Human Recombinant Protein Products for FGF7: 
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    OriGene Purified Proteins (see all 2): FGF7
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    Novus Biologicals FGF7 Proteins
    Novus Biologicals FGF7 Lysates
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    ProSpec Recombinant Protein for FGF7
    Uscn Proteins for FGF7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ----
    GO:0005794Golgi apparatus IEA--

    FGF7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FGF7


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FGF7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry P21781

    ProtoNet protein and cluster: P21781

    2 Blocks protein families:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781
    Similarity: Belongs to the heparin-binding growth factors family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF7_HUMAN, P21781
    Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell
    differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major
    paracrine effector of normal epithelial cell proliferation

         Genatlas biochemistry entry for FGF7:
    fibroblast growth factor 7,expressed in epithelial tissues,including corneal and mammary epithelial cells,mitogenic for
    epithelial cells

         Summary:  
    During embryonic development, FGF7 as signaling molecule is secreted from the following cells: Metanephric Mesenchyme Cells in Metanephric Mesenchyme It affects the following cells: Multipotent Lung Progenitor Cells in Ventral Foregut Endoderm

    FGF7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Posterior foregut endoderm, Immature proximal lung cells (see all 11).

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005111type 2 fibroblast growth factor receptor binding ----
    GO:0005515protein binding IPI1309608
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--
    GO:0042056chemoattractant activity IDA17449030
         
    FGF7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FGF7:
     Decreased viability with pacli 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fgf7):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  integument 
     nervous system  renal/urinary system  reproductive system 

    FGF7 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Fgf7tm1Efu for FGF7
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FGF7 

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    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF7 (see all 83):
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    SwitchGear 3'UTR luciferase reporter plasmidFGF7 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/30 super-pathways (see all 30About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    Apoptotic Pathways in Synovial Fibroblasts1.00
    ERK5 Signaling0.61
    p53 Mediated Apoptosis0.84
    eIF2 Pathway0.60
    Mitochondrial Apoptosis0.73
    Rac1 Pathway0.58
    Telomerase Components in Cell Signaling0.72
    Nuclear Receptor Activation by Vitamin-A0.57
    2Signaling by FGFR
    8/12 pathways (see all 12)
    Signaling by FGFR1.00
    DAP12 signaling0.83
    Downstream signaling of activated FGFR0.92
    Signaling by EGFR in Cancer0.83
    Signaling by FGFR in disease0.91
    DAP12 interactions0.76
    Signaling by ERBB20.89
    Signaling by PDGF0.72
    3PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    PI-3K cascade1.00
    PI3K/AKT activation0.97
    PIP3 activates AKT signaling1.00
    GAB1 signalosome0.96
    PI3K/AKT Signaling in Cancer1.00
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI3K events in ERBB2 signaling1.00
    Signaling by SCF-KIT0.72
    4IRS-related events
    IRS-related events1.00
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    IRS-mediated signalling0.98
    IGF1R signaling cascade0.90
    Insulin receptor signalling cascade0.94
    PI3K Cascade0.84
    IRS-related events triggered by IGF1R0.93
    Signaling by Insulin receptor0.74
    5GPCR Pathway
    GPCR Pathway1.00
    Estrogen Pathway0.55
    Ras Pathway0.62
    Pancreatic Adenocarcinoma0.55
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.53
    NFAT in Immune Response0.58
    P2Y Receptor Signaling0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FGF7
        Development FGF-family signaling

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF7 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF7
        Development FGF-family signaling

    2 BioSystems Pathways for FGF7 
        Regulation of Actin Cytoskeleton
    Glypican 3 network

    5/48        Reactome Pathways for FGF7 (see all 48)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    4         Kegg Pathways  (Kegg details for FGF7):
        MAPK signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Melanoma


    FGF7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for FGF7 (P217811, 3 ENSP000002678434) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR2P21802-31, ENSP000004102944EBI-3937699,EBI-6354683 I2D: score=1 STRING: ENSP00000410294
    HSPG2P981603, ENSP000003638274I2D: score=2 STRING: ENSP00000363827
    COL1A1P024523, ENSP000002259644I2D: score=1 STRING: ENSP00000225964
    COL3A1P024613, ENSP000003044084I2D: score=1 STRING: ENSP00000304408
    COL6A1P121093, ENSP000003551804I2D: score=1 STRING: ENSP00000355180
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development ----
    GO:0006656phosphatidylcholine biosynthetic process ----
    GO:0007165signal transduction NAS2475908
    GO:0008284positive regulation of cell proliferation IGI8663044
    GO:0008286insulin receptor signaling pathway TAS--

    FGF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF7

    1 HMDB Compound for FGF7    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--
    10/81 Novoseek chemical compound relationships for FGF7 gene (see all 81)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    palifermin 93.5 38 17059384 (2), 15681392 (1), 17103218 (1), 18708365 (1) (see all 24)
    kepivance 85.8 1 15843784 (1)
    vegf 53 61 17920582 (4), 19930634 (4), 18674742 (2), 14681639 (2) (see all 33)
    heparan sulfate 47.1 22 19755711 (2), 11724555 (2), 16315317 (2), 9466688 (2) (see all 8)
    heparin 44.7 112 10593896 (9), 8806707 (6), 9636026 (5), 8783184 (5) (see all 29)
    bromodeoxyuridine 39.7 21 7658592 (2), 12947032 (1), 10329601 (1), 11076805 (1) (see all 12)
    tyrosine 38.3 30 11286634 (2), 11757032 (2), 15672868 (2), 9692365 (2) (see all 18)
    amifostine 37.1 2 12621500 (1), 15018311 (1)
    thymidine 33.4 18 10691999 (2), 14695201 (1), 17593825 (1), 17953372 (1) (see all 12)
    dextran sulfate sodium 32.1 2 17449036 (1), 16698153 (1)

    Search CenterWatch for drugs/clinical trials and news about FGF7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FGF7 gene: 
    NM_002009.3  

    Unigene Cluster for FGF7:

    Fibroblast growth factor 7
    Hs.567268  [show with all ESTs]
    Unigene Representative Sequence: NM_002009
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267843(uc001zxn.3) ENST00000560270 ENST00000560765 ENST00000560979
    ENST00000560704

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    hsa-miR-582-3p hsa-miR-361-5p hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-199a-3p hsa-miR-632 hsa-miR-3653
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF7

    Additional cDNA sequence: 

    AK313160.1 BC010956.1 CR542002.1 M60828.1 S81661.1 

    8 DOTS entries:

    DT.211693  DT.95260045  DT.121049828  DT.121049830  DT.121049713  DT.121049744  DT.121049814  DT.121096587 

    24/67 AceView cDNA sequences (see all 67):

    CR617541 AU280372 CR593889 AL703203 W79892 AL525382 BQ953882 BX094084 
    BX483338 CR609737 BU838527 BX328135 CD679601 CB998699 BI222235 BP379722 
    AL525342 S81661 BP335485 BP374851 BQ892377 BG571312 CD613700 BM685449 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    FGF7 Expression
    About this image

    FGF7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusChoroid Plexus Progenitor CellsChoroid Plexus
    EndotheliumMicrovesselsPericytesPericytes
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    mK3 (Cell line)Kidney
    mK4 (Cell line)Kidney

    See FGF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF7

    SOURCE GeneReport for Unigene cluster: Hs.567268

    UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781
    Tissue specificity: Epithelial cell

        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF7: 
              Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Wound Healing in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FGF7 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FGF71 fibroblast growth factor 7 85.74(n)
    82.99(a)
      415439  NM_001012525.1  NP_001012543.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF76
    --
    75(a)
    1 ↔ 1
    GL343506.1(157358-184607)
    zebrafish
    (Danio rerio)
    Actinopterygii fgf71 fibroblast growth factor 7 60.99(n)
    58.16(a)
      493181  NM_001007761.1  NP_001007762.1 
    worm
    (Caenorhabditis elegans)
    Secernentea let-7566
    Protein let-756
    12(a)
    1 → many
    III(6407076-6409965)


    ENSEMBL Gene Tree for FGF7 (if available)
    TreeFam Gene Tree for FGF7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF7 gene
    FGF122  FGF52  FGF202  FGF162  FGF42  FGF92  FGF62  FGF32  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    18/19 SIMAP similar genes for FGF7 using alignment to 5 protein entries:     FGF7_HUMAN (see all proteins) (see all similar genes):
    KGFLP1    KGFLP2    PRED3    FGF10    FGF16    FGF22
    FGF9    FGF20    FGF8    FGF5    FGF12    FGF13
    FGF6    FGF11    FGF4    FGF3    FGF2    fgf gene

    FGF7 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for FGF7 (see all 8)
    PGOHUM00000262128 PGOHUM00000239126 PGOHUM00000236072 PGOHUM00000236104 PGOHUM00000236144


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/953 NCBI SNPs in FGF7 are shown (see all 953    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116383141,2
    C,H--26545850(+) ATTCTG/AAGCCT 1 -- us2k13Minor allele frequency- A:0.23NA 124
    rs125930681,2
    C,F,H--26546223(+) TCACAT/GAGAGA 1 -- us2k14Minor allele frequency- G:0.02EA NS NA 278
    rs1125642761,2
    --26546284(+) GTGCAT/CGCGTG 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs733982841,2
    C--26546304(+) AGGAGT/CATATA 1 -- us2k13Minor allele frequency- C:0.16WA NA 240
    rs125910521,2
    H--26546354(+) ATTTAG/TATAGA 1 -- us2k10--------
    rs733982861,2
    C--26547293(+) TGCTTC/TCAATG 1 -- ut511Minor allele frequency- T:0.50WA 2
    rs777302491,2
    --26547873(+) TGCAGT/CATGGT 1 -- int11Minor allele frequency- C:0.01WA 118
    rs345312311,2
    C,F--26548574(+) TTACAT/CGGAAG 2 /T /M mis13Minor allele frequency- C:0.11NA 70
    rs733982871,2
    C--26549149(+) ACTTAA/TTCTGT 1 -- int12Minor allele frequency- T:0.02WA 120
    rs727272861,2
    --26549374(+) AAAAAA/GTGGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for FGF7 (49715293 - 49965293 bp, first 250kb of FGF7)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for FGF7
         3 CNVs: 87685 72246 30712
         1 Indel: 58725

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FGF7 for disorders           About GeneDecksing

    OMIM gene information: 148180    OMIM disorders: --

    20/81 diseases for FGF7 (see all 81):    About MalaCards
    graft versus host disease    middle ear cholesteatoma    cleft lip/palate    chronic venous leg ulcers
    oncogenic osteomalacia    clear cell acanthoma    gingival overgrowth    congenital diaphragmatic hernia
    dry eye syndrome    short bowel syndrome    pfeiffer syndrome    bronchopulmonary dysplasia
    acanthoma    cleft lip    inflammatory bowel disease    bazex syndrome
    hernia    squamous cell carcinoma    chronic obstructive pulmonary disease    cholesteatoma

    2 diseases from the University of Copenhagen DISEASES database for FGF7:
    Cholesteatoma     Cancer

    10/81 Novoseek disease relationships for FGF7 gene (see all 81)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stomatitis 67.8 15 11258848 (1), 18708365 (1), 15327889 (1), 12182998 (1) (see all 11)
    mucositis 67.1 28 18560408 (4), 12139710 (3), 9422575 (2), 11045187 (1) (see all 18)
    epithelial hyperplasia 54.5 9 12492503 (1), 7560096 (1), 9109075 (1), 7977634 (1) (see all 5)
    benign prostatic hyperplasia 51.3 16 10411093 (3), 9285567 (1), 9844400 (1), 18386288 (1) (see all 11)
    apert syndrome 48 2 11596961 (1), 14613973 (1)
    hematologic malignancies 41.8 7 18708365 (1), 15327889 (1), 16499139 (1), 18632516 (1) (see all 7)
    acute respiratory distress 39.9 6 10921560 (2), 19325470 (2), 16672636 (1)
    hyperplasia 35.4 20 9788959 (3), 11076805 (2), 10766812 (2), 9256328 (1) (see all 13)
    pfeiffer syndrome 35.2 1 14613973 (1)
    respiratory distress syndrome 33.2 6 10921560 (2), 19325470 (2), 16672636 (1)

    Human Genome Epidemiology (HuGE) Navigator: FGF7 (1 document)

    Export disorders for FGF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF7 gene, integrated from 9 sources (see all 726):
    (articles sorted by number of sources associating them with FGF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PubMed id 15806171)1, 2, 9 Beer H.-D....Werner S. (2005)
    2. Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)1, 2 Ornitz D.M....Goldfarb M. (1996)
    3. Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively. (PubMed id 7749227)1, 3 Mattei M.G....Mason I. (1995)
    4. Emergence of the keratinocyte growth factor multigene family during the great ape radiation. (PubMed id 1409637)1, 3 Kelley M.J....Aaronson S.A. (1992)
    5. Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. (PubMed id 1664700)1, 2 Aaronson S.A.... Rubin J.S. (1991)
    6. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. (PubMed id 2475908)1, 2 Finch P.W.... Aaronson S.A. (1989)
    7. Purification and characterization of a newly identified growth factor specific for epithelial cells. (PubMed id 2915979)1, 2 Rubin J.S....Aaronson S.A. (1989)
    8. Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer. (PubMed id 11000522)1, 9 Parrott J.A....Skinner M.K. (2000)
    9. Role of keratinocyte growth factor in the pathogenesis of autosomal dominant polycystic kidney disease. (PubMed id 16141466)1, 9 Mei C....Sun T. (2005)
    10. Elevated expression of FGF7 protein is common in human gastric diseases. (PubMed id 17049492)1, 9 Shaoul R....Ron D. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2252 HGNC: 3685 AceView: FGF7 Ensembl:ENSG00000140285 euGenes: HUgn2252
    ECgene: FGF7 Kegg: 2252 H-InvDB: FGF7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FGF7 gene:
    Search GeneIP for patents involving FGF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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