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Aliases for FGF7 Gene

Aliases for FGF7 Gene

  • Fibroblast Growth Factor 7 2 3
  • Keratinocyte Growth Factor 2 3 4
  • Heparin-Binding Growth Factor 7 3 4
  • HBGF-7 3 4
  • FGF-7 3 4
  • KGF 3 4
  • Fibroblast Growth Factor 7 (Keratinocyte Growth Factor) 2

External Ids for FGF7 Gene

Previous GeneCards Identifiers for FGF7 Gene

  • GC15P045272
  • GC15P042761
  • GC15P047294
  • GC15P047431
  • GC15P047502
  • GC15P049715
  • GC15P026547

Summaries for FGF7 Gene

Entrez Gene Summary for FGF7 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF7 Gene

FGF7 (Fibroblast Growth Factor 7) is a Protein Coding gene. Diseases associated with FGF7 include bazex syndrome and familial progressive hyperpigmentation. Among its related pathways are PI3K-Akt signaling pathway and PI3K/AKT Signaling in Cancer. GO annotations related to this gene include growth factor activity and chemoattractant activity. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF7 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

Gene Wiki entry for FGF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF7 Gene

Genomics for FGF7 Gene

Regulatory Elements for FGF7 Gene

Genomic Location for FGF7 Gene

Chromosome:
15
Start:
49,423,096 bp from pter
End:
49,488,775 bp from pter
Size:
65,680 bases
Orientation:
Plus strand

Genomic View for FGF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF7 Gene

Proteins for FGF7 Gene

  • Protein details for FGF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21781-FGF7_HUMAN
    Recommended name:
    Fibroblast growth factor 7
    Protein Accession:
    P21781
    Secondary Accessions:
    • H0YNY5
    • Q6FGV5
    • Q96FG5

    Protein attributes for FGF7 Gene

    Size:
    194 amino acids
    Molecular mass:
    22509 Da
    Quaternary structure:
    • Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

    Alternative splice isoforms for FGF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF7 Gene

Proteomics data for FGF7 Gene at MOPED

Post-translational modifications for FGF7 Gene

  • Glycosylation at Asn 45
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF7 Gene

Antibody Products

No data available for DME Specific Peptides for FGF7 Gene

Domains & Families for FGF7 Gene

Gene Families for FGF7 Gene

Graphical View of Domain Structure for InterPro Entry

P21781

UniProtKB/Swiss-Prot:

FGF7_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF7: view

Function for FGF7 Gene

Molecular function for FGF7 Gene

GENATLAS Biochemistry:
fibroblast growth factor 7,expressed in epithelial tissues,including corneal and mammary epithelial cells,mitogenic for epithelial cells
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

LifeMap Function Summary for FGF7 Gene

Gene Ontology (GO) - Molecular Function for FGF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding --
GO:0005111 type 2 fibroblast growth factor receptor binding IEA --
GO:0005515 protein binding IPI 1309608
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with FGF7: view
genes like me logo Genes that share phenotypes with FGF7: view

Animal Models for FGF7 Gene

MGI Knock Outs for FGF7:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF7 Gene

Localization for FGF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF7 Gene COMPARTMENTS Subcellular localization image for FGF7 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
golgi apparatus 2
nucleus 2
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for FGF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with FGF7: view

Pathways & Interactions for FGF7 Gene

SuperPathways for FGF7 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI3K/AKT Signaling in Cancer
4 GPCR Pathway
5 TGF-Beta Pathway
genes like me logo Genes that share pathways with FGF7: view

PCR Array Products

Gene Ontology (GO) - Biological Process for FGF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001541 ovarian follicle development IEA --
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006656 phosphatidylcholine biosynthetic process IEA --
genes like me logo Genes that share ontologies with FGF7: view

No data available for SIGNOR curated interactions for FGF7 Gene

Drugs & Compounds for FGF7 Gene

(39) Drugs for FGF7 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 672,226
Amifostine Approved, Investigational Pharma 81
Bicalutamide Approved Pharma Androgen receptor antagonist, Non-steroidal androgen receptor antagonist 158
Bleomycin Approved Pharma 142
Celecoxib Approved, Investigational Pharma Inhibition, Inhibitor Selective cyclooxygenase-2 (COX-2) inhibitor 395

(42) Additional Compounds for FGF7 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,25 DIHYDROXY VITAMIN D3
12-O-Tetradecanoylphorbol 13-acetate
5fluorouracil
Actinomycin D
adenylate
genes like me logo Genes that share compounds with FGF7: view

Transcripts for FGF7 Gene

Unigene Clusters for FGF7 Gene

Fibroblast growth factor 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF7 Gene

No ASD Table

Relevant External Links for FGF7 Gene

GeneLoc Exon Structure for
FGF7
ECgene alternative splicing isoforms for
FGF7

Expression for FGF7 Gene

mRNA expression in normal human tissues for FGF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FGF7 Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF7 Gene



SOURCE GeneReport for Unigene cluster for FGF7 Gene Hs.567268

mRNA Expression by UniProt/SwissProt for FGF7 Gene

P21781-FGF7_HUMAN
Tissue specificity: Epithelial cell
genes like me logo Genes that share expression patterns with FGF7: view

Protein tissue co-expression partners for FGF7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FGF7 Gene

Orthologs for FGF7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGF7 35
  • 94.85 (n)
  • 97.42 (a)
FGF7 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF7 35
  • 96.05 (n)
  • 97.42 (a)
FGF7 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf7 35
  • 91.92 (n)
  • 94.33 (a)
Fgf7 16
Fgf7 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGF7 35
  • 100 (n)
  • 100 (a)
FGF7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf7 35
  • 89.35 (n)
  • 90.21 (a)
oppossum
(Monodelphis domestica)
Mammalia FGF7 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF7 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF7 35
  • 85.74 (n)
  • 82.99 (a)
FGF7 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF7 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf7 35
  • 76.46 (n)
  • 75.77 (a)
zebrafish
(Danio rerio)
Actinopterygii fgf7 35
  • 60.99 (n)
  • 58.16 (a)
fgf7 36
  • 49 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 36
  • 17 (a)
OneToMany
Species with no ortholog for FGF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF7 Gene

ENSEMBL:
Gene Tree for FGF7 (if available)
TreeFam:
Gene Tree for FGF7 (if available)

Paralogs for FGF7 Gene

Paralogs for FGF7 Gene

genes like me logo Genes that share paralogs with FGF7: view

Variants for FGF7 Gene

Sequence variations from dbSNP and Humsavar for FGF7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
VAR_049063 -
VAR_071038 -

Structural Variations from Database of Genomic Variants (DGV) for FGF7 Gene

Variant ID Type Subtype PubMed ID
nsv833002 CNV Gain 17160897
nsv819023 CNV Loss 19587683
nsv9263 CNV Gain 18304495
nsv526246 CNV Loss 19592680
esv27180 CNV Loss 19812545

Variation tolerance for FGF7 Gene

Residual Variation Intolerance Score: 49.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF7 Gene

HapMap Linkage Disequilibrium report
FGF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF7 Gene

Disorders for FGF7 Gene

MalaCards: The human disease database

(13) MalaCards diseases for FGF7 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
bazex syndrome
  • bazex-dupre-christol syndrome
familial progressive hyperpigmentation
  • melanosis diffusa congenita
oncogenic osteomalacia
  • oo
apert syndrome
  • acrocephalosyndactyly
clear cell acanthoma
  • pale acanthoma
- elite association
Search FGF7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGF7

Genetic Association Database (GAD)
FGF7
Human Genome Epidemiology (HuGE) Navigator
FGF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF7
genes like me logo Genes that share disorders with FGF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF7 Gene

Publications for FGF7 Gene

  1. Early alterations of growth factor patterns in bronchoalveolar lavage fluid from preterm infants developing bronchopulmonary dysplasia. (PMID: 19770691) Been J.V. … Zimmermann L.J. (Pediatr. Res. 2010) 23 67
  2. KGF Promotes Paracrine Activation of the SCF/c-KIT Axis from Human Keratinocytes to Melanoma Cells. (PMID: 20360932) Belleudi F. … Torrisi M.R. (Transl Oncol 2010) 23 67
  3. The essential oils of Chamaecyparis obtusa promote hair growth through the induction of vascular endothelial growth factor gene. (PMID: 19576968) Lee G.S. … Jeung E.B. (Fitoterapia 2010) 23 67
  4. Reduced expression of fibroblast growth factor receptor 2IIIb in hepatocellular carcinoma induces a more aggressive growth. (PMID: 20093481) Amann T. … Hellerbrand C. (Am. J. Pathol. 2010) 23 67
  5. Keratinocyte growth factor protected cultured human keratinocytes exposed to oxidative stress. (PMID: 20126895) Gragnani A. … Ferreira L.M. (Acta Cir Bras 2010) 23 67

Products for FGF7 Gene

Sources for FGF7 Gene

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