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FGF7 Gene

protein-coding   GIFtS: 67
GCID: GC15P049715

Fibroblast Growth Factor 7

(Previous name: fibroblast growth factor 7 (keratinocyte growth factor))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 71 2     HBGF-72 3
Keratinocyte Growth Factor1 2 3     KGF2 3
Heparin-Binding Growth Factor 72 3     Fibroblast Growth Factor 7 (Keratinocyte Growth Factor)1
FGF-72 3     

External Ids:    HGNC: 36851   Entrez Gene: 22522   Ensembl: ENSG000001402857   OMIM: 1481805   UniProtKB: P217813   

Export aliases for FGF7 gene to outside databases

Previous GC identifers: GC15P045272 GC15P042761 GC15P047294 GC15P047431 GC15P047502 GC15P026547


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF7 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This
protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited
in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene
implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung
organogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF7 Gene:
FGF7 (fibroblast growth factor 7) is a protein-coding gene. Diseases associated with FGF7 include clear cell acanthoma, and acanthoma. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781
Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell
differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible
major paracrine effector of normal epithelial cell proliferation

Gene Wiki entry for FGF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF7 gene promoter:
         C/EBPbeta   AP-1   ATF-2   FOXD1   HNF-3beta   C/EBPalpha   STAT3   c-Jun   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF7 promoter sequence
   Search Chromatin IP Primers for FGF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

FGF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P049715:  view genomic region     (about GC identifiers)

Start:
49,715,293 bp from pter      End:
49,780,972 bp from pter
Size:
65,680 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781 (See protein sequence)
Recommended Name: Fibroblast growth factor 7 precursor  
Size: 194 amino acids; 22509 Da
Subunit: Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their
receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors

Explore the universe of human proteins at neXtProt for FGF7: NX_P21781

Explore proteomics data for FGF7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn45
  • Modification sites at PhosphoSitePlus

  • See FGF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002000.1  
    ENSEMBL proteins: 
     ENSP00000267843   ENSP00000454205   ENSP00000453048   ENSP00000453980  
    Reactome Protein details: P21781

    FGF7 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FGF7
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    Novus Biologicals FGF7 Proteins
    Novus Biologicals FGF7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FGF7
    Cloud-Clone Corp. Proteins for FGF7

    FGF7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FGF7 (KGF/FGF-7)
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    Abcam antibodies for FGF7
    Cloud-Clone Corp. Antibodies for FGF7
    ThermoFisher Antibodies for FGF7
    LSBio Antibodies in human, mouse, rat for FGF7

    FGF7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FGF7
    R&D Systems ELISAs for FGF7 (KGF/FGF-7)         (see all)
    GenScript Custom Assay Services for FGF7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF7
    Cloud-Clone Corp. CLIAs for FGF7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR028247 FGF7
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam

    Graphical View of Domain Structure for InterPro Entry P21781

    ProtoNet protein and cluster: P21781

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781
    Similarity: Belongs to the heparin-binding growth factors family


    FGF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF7_HUMAN, P21781
    Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell
    differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible
    major paracrine effector of normal epithelial cell proliferation

         Genatlas biochemistry entry for FGF7:
    fibroblast growth factor 7,expressed in epithelial tissues,including corneal and mammary epithelial
    cells,mitogenic for epithelial cells

         Summary: 
    During embryonic development, FGF7 as signaling molecule is secreted from the following cells:
                
    Kidney: Metanephric Mesenchyme Cells (Metanephric Mesenchyme)

    It affects the following cells:
          selected tissues (see all 3)
    Gut Tube: Multipotent Lung Progenitor Cells (Ventral Foregut Endoderm)
    Epidermis: Basal Keratinocytes (Embryonic Epidermis)

    FGF7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 3)      fully expand
    Pancreas: Pancreatic progenitor-like cells, Primitive gut tube      fully expand to see all 4 cells
    Lung: Lung Epithelial Progenitors, Immature proximal lung cells      fully expand to see all 3 cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IEA--
    GO:0005515protein binding IPI1309608
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--
    GO:0042056chemoattractant activity IDA17449030
         
    FGF7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FGF7:
     Decreased viability with pacli 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fgf7):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  integument 
     nervous system  renal/urinary system  reproductive system 

    FGF7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fgf7tm1Efu for FGF7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF7

    miRNA
    Products:
        
    miRTarBase miRNAs that target FGF7:
    hsa-mir-20a-5p (MIRT050488), hsa-mir-155-5p (MIRT003482)

    Block miRNA regulation of human, mouse, rat FGF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF7 (see all 83):
    hsa-miR-582-3p hsa-miR-361-5p hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-199a-3p hsa-miR-632 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidFGF7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FGF7
    Predesigned siRNA for gene silencing in human, mouse, rat FGF7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FGF7

    Clone
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    OriGene clones in human, mouse for FGF7 (see all 6)
    OriGene ORF clones in mouse, rat for FGF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FGF7 (NM_002009)
    Sino Biological Human cDNA Clone for FGF7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FGF7 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF7_HUMAN, P21781: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    golgi apparatus2
    plasma membrane2
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005794Golgi apparatus IEA--

    FGF7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF7 About   (see all 32)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    Development FGF family signaling0.43
    SHC-mediated cascade0.79
    FGFR2b ligand binding and activation0.00
    FGFR2 ligand binding and activation0.74
    Activated point mutants of FGFR20.00
    FRS2-mediated cascade0.70
    Signaling by FGFR2 mutants0.00
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF7 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF7
        Development FGF-family signaling

    2 BioSystems Pathways for FGF7
        Regulation of Actin Cytoskeleton
    Glypican 3 network


    Selected Reactome Pathways for FGF7 (see all 11)
        Signaling by FGFR mutants
    PI3K Cascade
    Phospholipase C-mediated cascade
    FRS2-mediated cascade
    FGFR2b ligand binding and activation


    Selected Kegg Pathways  (Kegg details for FGF7) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton


    FGF7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF7: 
              Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Wound Healing in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGF7 (P217811, 3 ENSP000002678434) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR2P21802-31, ENSP000004102944EBI-3937699,EBI-6354683 I2D: score=1 STRING: ENSP00000410294
    HSPG2P981603, ENSP000003638274I2D: score=2 STRING: ENSP00000363827
    COL1A1P024523, ENSP000002259644I2D: score=1 STRING: ENSP00000225964
    COL3A1P024613, ENSP000003044084I2D: score=1 STRING: ENSP00000304408
    COL6A1P121093, ENSP000003551804I2D: score=1 STRING: ENSP00000355180
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS2475908
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008284positive regulation of cell proliferation IGI8663044
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--

    FGF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF7

    1 HMDB Compound for FGF7    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    Selected Novoseek inferred chemical compound relationships for FGF7 gene (see all 81)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    palifermin 93.5 38 17059384 (2), 15681392 (1), 17103218 (1), 18708365 (1) (see all 24)
    kepivance 85.8 1 15843784 (1)
    vegf 53 61 17920582 (4), 19930634 (4), 18674742 (2), 14681639 (2) (see all 33)
    heparan sulfate 47.1 22 19755711 (2), 11724555 (2), 16315317 (2), 9466688 (2) (see all 8)
    heparin 44.7 112 10593896 (9), 8806707 (6), 9636026 (5), 8783184 (5) (see all 29)
    bromodeoxyuridine 39.7 21 7658592 (2), 12947032 (1), 10329601 (1), 11076805 (1) (see all 12)
    tyrosine 38.3 30 11286634 (2), 11757032 (2), 15672868 (2), 9692365 (2) (see all 18)
    amifostine 37.1 2 12621500 (1), 15018311 (1)
    thymidine 33.4 18 10691999 (2), 14695201 (1), 17593825 (1), 17953372 (1) (see all 12)
    dextran sulfate sodium 32.1 2 17449036 (1), 16698153 (1)



    FGF7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FGF7 gene: 
    NM_002009.3  

    Unigene Cluster for FGF7:

    Fibroblast growth factor 7
    Hs.567268  [show with all ESTs]
    Unigene Representative Sequence: NM_002009
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267843(uc001zxn.3) ENST00000560270 ENST00000560765 ENST00000560979
    ENST00000560704
    miRNA
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    Block miRNA regulation of human, mouse, rat FGF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF7 (see all 83):
    hsa-miR-582-3p hsa-miR-361-5p hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-199a-3p hsa-miR-632 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidFGF7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FGF7
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    OriGene ORF clones in mouse, rat for FGF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FGF7 (NM_002009)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF7
    Primer
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    OriGene qPCR primer pairs and template standards for FGF7
    OriGene qSTAR qPCR primer pairs in human, mouse for FGF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF7
      QuantiTect SYBR Green Assays in human, mouse, rat FGF7
      QuantiFast Probe-based Assays in human, mouse, rat FGF7

    Additional mRNA sequence: 

    AK313160.1 BC010956.1 CR542002.1 M60828.1 S81661.1 

    8 DOTS entries:

    DT.211693  DT.95260045  DT.121049828  DT.121049830  DT.121049713  DT.121049744  DT.121049814  DT.121096587 

    Selected AceView cDNA sequences (see all 67):

    AU280372 CR609737 BU838527 BX094084 AL703203 W79892 AL525382 BQ953882 
    CR617541 CR593889 BX483338 BX328135 CR542002 AW069586 BG571122 BI222235 
    BP335485 BP379722 S81661 CF594251 CD613700 AL525342 AL079980 BQ026844 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FGF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FGF7 Expression
    About this image


    FGF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 6 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
             Human neonatal dermal fibroblasts (Dermagraft)
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             mK3
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Epidermis (Integumentary System)
             MSC-containing human skin substitute (Grafix)
    FGF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567268

    UniProtKB/Swiss-Prot: FGF7_HUMAN, P21781
    Tissue specificity: Epithelial cell

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF7: 
              Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Wound Healing in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for FGF7
    OriGene qSTAR qPCR primer pairs in human, mouse for FGF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF7
    QuantiTect SYBR Green Assays in human, mouse, rat FGF7
    QuantiFast Probe-based Assays in human, mouse, rat FGF7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf71 , 5 fibroblast growth factor 71, 5 91.92(n)1
    94.33(a)1
      2 (61.76 cM)5
    141781  NM_008008.41  NP_032034.11 
     1260346585 
    chicken
    (Gallus gallus)
    Aves FGF71 fibroblast growth factor 7 85.74(n)
    82.99(a)
      415439  NM_001012525.1  NP_001012543.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF76
    fibroblast growth factor 7
    75(a)
    1 ↔ 1
    GL343506.1(157358-184607)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fgf71 fibroblast growth factor 7 76.46(n)
    75.77(a)
      496833  NM_001011366.1  NP_001011366.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf71 fibroblast growth factor 7 60.99(n)
    58.16(a)
      493181  NM_001007761.1  NP_001007762.1 


    ENSEMBL Gene Tree for FGF7 (if available)
    TreeFam Gene Tree for FGF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF7 gene
    FGF122  FGF162  FGF52  FGF202  FGF42  FGF62  FGF92  FGF32  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    Selected SIMAP similar genes for FGF7 using alignment to 5 protein entries:     FGF7_HUMAN (see all proteins) (see all similar genes):
    KGFLP1    KGFLP2    PRED3    FGF10    FGF16    FGF22
    FGF9    FGF20    FGF8    FGF5    FGF12    FGF13
    FGF6    FGF11    FGF4    FGF3    FGF2    fgf gene

    FGF7 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for FGF7 (see all 8)
    PGOHUM00000262128 PGOHUM00000239126 PGOHUM00000236072 PGOHUM00000236104 PGOHUM00000236144


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF7 (see all 1108)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341188711,2
    C--26568026(+) AGAGTC/-AGTTG 1 -- int13Minor allele frequency- -:0.17NA CSA 6
    rs717343911,2
    C--26573204(+) GAATTCAAA/-  
            
    CAGAG
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs724271101,2
    C--26573206(+) ATTCA-/AACA  
            
    GAGAC
    1 -- int10--------
    rs345452021,2
    C--26587655(+) GTCTC-/AA/AAA
            
    AAAAA
    2 -- int1 cds10--------
    rs1421658531,2
    C--26589697(+) CCAAA-/AAAG  
            
    AGAGA
    1 -- int10--------
    rs761015851,2
    C--26589698(+) CAAAA-/AAGA  
            
    GAGAC
    1 -- int10--------
    rs2005362071,2
    C--26589698(+) CAAAAA/GAGAGA 1 -- int10--------
    rs1419461391,2
    C--26599110(+) ATAAA-/AGAT  
            
    AGAAT
    1 -- int10--------
    rs559629081,2
    C--26600347(+) TTTTGT/GTTTTT 1 -- int13Minor allele frequency- G:0.20WA NA CSA 5
    rs1465612821,2
    C--29779749(+) CAGAGC/TGTAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FGF7 (49715293 - 49780972 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FGF7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819023CNV Loss19587683
    esv27180CNV Loss19812545
    nsv526246CNV Loss19592680
    nsv833002CNV Gain17160897
    nsv9263CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF7
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 148180    OMIM disorders: --

    Selected diseases for FGF7 (see all 69):    
    About MalaCards
    clear cell acanthoma    acanthoma    oncogenic osteomalacia    short bowel syndrome
    craniosynostosis, syndromic    bronchopulmonary dysplasia    gingival overgrowth    dry eye syndrome
    osteomalacia    gingivitis    chronic venous leg ulcers    cholesteatoma
    pulmonary edema    paraneoplastic syndromes    gastric ulcer    craniosynostosis
    middle ear cholesteatoma    fasciitis    teratocarcinoma    hypophosphatemia

    2 diseases from the University of Copenhagen DISEASES database for FGF7:
    Cholesteatoma     Cancer

    FGF7 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FGF7 gene (see all 81)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stomatitis 67.8 15 11258848 (1), 18708365 (1), 15327889 (1), 12182998 (1) (see all 11)
    mucositis 67.1 28 18560408 (4), 12139710 (3), 9422575 (2), 11045187 (1) (see all 18)
    epithelial hyperplasia 54.5 9 12492503 (1), 7560096 (1), 9109075 (1), 7977634 (1) (see all 5)
    benign prostatic hyperplasia 51.3 16 10411093 (3), 9285567 (1), 9844400 (1), 18386288 (1) (see all 11)
    apert syndrome 48 2 11596961 (1), 14613973 (1)
    hematologic malignancies 41.8 7 18708365 (1), 15327889 (1), 16499139 (1), 18632516 (1) (see all 7)
    acute respiratory distress 39.9 6 10921560 (2), 19325470 (2), 16672636 (1)
    hyperplasia 35.4 20 9788959 (3), 11076805 (2), 10766812 (2), 9256328 (1) (see all 13)
    pfeiffer syndrome 35.2 1 14613973 (1)
    respiratory distress syndrome 33.2 6 10921560 (2), 19325470 (2), 16672636 (1)

    Genetic Association Database (GAD): FGF7
    Human Genome Epidemiology (HuGE) Navigator: FGF7 (1 document)

    Export disorders for FGF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF7 gene, integrated from 10 sources (see all 736):
    (articles sorted by number of sources associating them with FGF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PubMed id 15806171)1, 2, 9 Beer H.-D....Werner S. (Oncogene 2005)
    2. Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. (PubMed id 21565293)1, 4 Teumer A....VAPlzke H. (Am. J. Hum. Genet. 2011)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)1, 2 Ornitz D.M.... Goldfarb M. (J. Biol. Chem. 1996)
    5. Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively. (PubMed id 7749227)1, 3 Mattei M.G....Mason I. (Mamm. Genome 1995)
    6. Emergence of the keratinocyte growth factor multigene family during the great ape radiation. (PubMed id 1409637)1, 3 Kelley M.J....Aaronson S.A. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    7. Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. (PubMed id 1664700)1, 2 Aaronson S.A.... Rubin J.S. (Ann. N. Y. Acad. Sci. 1991)
    8. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. (PubMed id 2475908)1, 2 Finch P.W.... Aaronson S.A. (Science 1989)
    9. Purification and characterization of a newly identified growth factor specific for epithelial cells. (PubMed id 2915979)1, 2 Rubin J.S....Aaronson S.A. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    10. Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer. (PubMed id 11000522)1, 9 Parrott J.A....Skinner M.K. (Mol. Cell. Endocrinol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2252 HGNC: 3685 AceView: FGF7 Ensembl:ENSG00000140285 euGenes: HUgn2252
    ECgene: FGF7 Kegg: 2252 H-InvDB: FGF7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGF7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF7 gene:
    Search GeneIP for patents involving FGF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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