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Aliases for FGF7 Gene

Aliases for FGF7 Gene

  • Fibroblast Growth Factor 7 2 3 5
  • Keratinocyte Growth Factor 2 3 4
  • Heparin-Binding Growth Factor 7 3 4
  • HBGF-7 3 4
  • FGF-7 3 4
  • KGF 3 4
  • Fibroblast Growth Factor 7 (Keratinocyte Growth Factor) 2

External Ids for FGF7 Gene

Previous GeneCards Identifiers for FGF7 Gene

  • GC15P045272
  • GC15P042761
  • GC15P047294
  • GC15P047431
  • GC15P047502
  • GC15P049715
  • GC15P026547

Summaries for FGF7 Gene

Entrez Gene Summary for FGF7 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF7 Gene

FGF7 (Fibroblast Growth Factor 7) is a Protein Coding gene. Diseases associated with FGF7 include Mucositis and Apert Syndrome. Among its related pathways are RET signaling and p70S6K Signaling. GO annotations related to this gene include growth factor activity and chemoattractant activity. An important paralog of this gene is FGF10.

UniProtKB/Swiss-Prot for FGF7 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

Gene Wiki entry for FGF7 Gene

Additional gene information for FGF7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF7 Gene

Genomics for FGF7 Gene

Regulatory Elements for FGF7 Gene

Enhancers for FGF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H049421 1.3 Ensembl ENCODE dbSUPER 19 +0.8 767 3 TBP CTCF RB1 ARNT ZSCAN4 DNMT3B ZNF2 RAD21 CHAMP1 CC2D1A FGF7 DTWD1 COPS2 ENSG00000259715 SECISBP2L GALK2 LOC105370811
GH15H049876 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +454.7 454653 3 CTCF TARDBP MAX SMC3 CEBPG RAD21 NR2F2 LOC102724587 FGF7 DTWD1 GC15P049911
GH15H049846 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.7 +424.7 424681 3 TBP MXI1 JUN MAX RAD21 BRCA1 POLR2A FOS MAFK CHD2 DTWD1 FAM227B FGF7 ATP8B4 LOC102724587 RLIMP3
GH15H049618 1.2 ENCODE 10.2 +198.9 198876 6 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GABPB1-AS1 CEP152 FAM227B ENSG00000259298 ENSG00000259618 USP8 DTWD1 FGF7 ENSG00000259715 GC15P049652
GH15H049154 1.1 ENCODE 11 -267.4 -267428 3 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 DTWD1 COPS2 DUT ENSG00000259488 CEP152 FGF7 SECISBP2L FAM227B NDUFAF4P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGF7 on UCSC Golden Path with GeneCards custom track

Promoters for FGF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076344 1804 3400 TBP CTCF ZNF654 JUND POLR2A RAD21

Genomic Location for FGF7 Gene

Chromosome:
15
Start:
49,423,096 bp from pter
End:
49,488,775 bp from pter
Size:
65,680 bases
Orientation:
Plus strand

Genomic View for FGF7 Gene

Genes around FGF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF7 Gene

Proteins for FGF7 Gene

  • Protein details for FGF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21781-FGF7_HUMAN
    Recommended name:
    Fibroblast growth factor 7
    Protein Accession:
    P21781
    Secondary Accessions:
    • H0YNY5
    • Q6FGV5
    • Q96FG5

    Protein attributes for FGF7 Gene

    Size:
    194 amino acids
    Molecular mass:
    22509 Da
    Quaternary structure:
    • Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

    Alternative splice isoforms for FGF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF7 Gene

Post-translational modifications for FGF7 Gene

  • Glycosylation at isoforms=245
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF7 Gene

Antibody Products

Assay Products

  • Cloud-Clone Corp. Assay Kits for FGF7
  • Abcam assays for FGF7

No data available for DME Specific Peptides for FGF7 Gene

Domains & Families for FGF7 Gene

Gene Families for FGF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P21781

UniProtKB/Swiss-Prot:

FGF7_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF7: view

Function for FGF7 Gene

Molecular function for FGF7 Gene

GENATLAS Biochemistry:
fibroblast growth factor 7,expressed in epithelial tissues,including corneal and mammary epithelial cells,mitogenic for epithelial cells
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

Phenotypes From GWAS Catalog for FGF7 Gene

Gene Ontology (GO) - Molecular Function for FGF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0005515 protein binding IPI 1309608
GO:0008083 growth factor activity IEA,TAS --
genes like me logo Genes that share ontologies with FGF7: view
genes like me logo Genes that share phenotypes with FGF7: view

Animal Models for FGF7 Gene

MGI Knock Outs for FGF7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FGF7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF7 Gene

Localization for FGF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF7 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
cytosol 2
golgi apparatus 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FGF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with FGF7: view

Pathways & Interactions for FGF7 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 GPCR Pathway
4 PI3K/AKT activation
5 TGF-Beta Pathway
genes like me logo Genes that share pathways with FGF7: view

Gene Ontology (GO) - Biological Process for FGF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction NAS 2475908
GO:0008284 positive regulation of cell proliferation IGI 8663044
GO:0008543 fibroblast growth factor receptor signaling pathway IGI,TAS --
GO:0008544 epidermis development TAS 7973639
genes like me logo Genes that share ontologies with FGF7: view

No data available for SIGNOR curated interactions for FGF7 Gene

Drugs & Compounds for FGF7 Gene

(45) Drugs for FGF7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 874,274

(36) Additional Compounds for FGF7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF7: view

Transcripts for FGF7 Gene

Unigene Clusters for FGF7 Gene

Fibroblast growth factor 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FGF7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FGF7 Gene

No ASD Table

Relevant External Links for FGF7 Gene

GeneLoc Exon Structure for
FGF7
ECgene alternative splicing isoforms for
FGF7

Expression for FGF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FGF7 Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF7 Gene



Protein tissue co-expression partners for FGF7 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGF7 Gene:

FGF7

SOURCE GeneReport for Unigene cluster for FGF7 Gene:

Hs.567268

mRNA Expression by UniProt/SwissProt for FGF7 Gene:

P21781-FGF7_HUMAN
Tissue specificity: Epithelial cell.

Evidence on tissue expression from TISSUES for FGF7 Gene

  • Nervous system(4.7)
  • Lung(3.3)
  • Intestine(2.8)
  • Skin(2.8)
  • Heart(2.5)
  • Muscle(2.4)
  • Eye(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with FGF7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF7 Gene

Orthologs for FGF7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF7 34 33
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FGF7 34 33
  • 96.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FGF7 34 33
  • 94.85 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf7 16 34 33
  • 91.92 (n)
rat
(Rattus norvegicus)
Mammalia Fgf7 33
  • 89.35 (n)
oppossum
(Monodelphis domestica)
Mammalia FGF7 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF7 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF7 33 34
  • 85.74 (n)
lizard
(Anolis carolinensis)
Reptilia FGF7 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf7 33
  • 76.46 (n)
zebrafish
(Danio rerio)
Actinopterygii fgf7 33 34
  • 60.99 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 34
  • 17 (a)
OneToMany
Species where no ortholog for FGF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF7 Gene

ENSEMBL:
Gene Tree for FGF7 (if available)
TreeFam:
Gene Tree for FGF7 (if available)

Paralogs for FGF7 Gene

Variants for FGF7 Gene

Sequence variations from dbSNP and Humsavar for FGF7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000028952 -- 49,453,212(+) CTGTT(A/T)AATCT intron-variant
rs1000060000 -- 49,452,837(+) CAAAC(A/G)TTAGC intron-variant
rs1000083641 -- 49,432,021(+) GTGCC(A/G)AAAAC intron-variant
rs1000095653 -- 49,446,566(+) AGGAT(C/T)GGTTG intron-variant
rs1000099087 -- 49,424,129(+) GTGTT(A/G)TTATC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FGF7 Gene

Variant ID Type Subtype PubMed ID
esv27180 CNV loss 19812545
esv3581696 CNV loss 25503493
esv3636428 CNV gain 21293372
nsv1043119 CNV loss 25217958
nsv526246 CNV loss 19592680
nsv819023 CNV loss 19587683
nsv833002 CNV gain 17160897
nsv9263 CNV gain 18304495
nsv974651 CNV duplication 23825009
nsv976934 CNV duplication 23825009
nsv984069 CNV duplication 23825009

Variation tolerance for FGF7 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF7 Gene

Disorders for FGF7 Gene

MalaCards: The human disease database

(16) MalaCards diseases for FGF7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mucositis
  • inflammatory disease of mucous membrane
apert syndrome
  • acrocephalosyndactylia
bazex syndrome
  • bazex-dupre-christol syndrome
cholesteatoma
  • congenital cholesteatoma
familial progressive hyperpigmentation
  • melanosis diffusa congenita
- elite association - COSMIC cancer census association via MalaCards
Search FGF7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGF7

Genetic Association Database (GAD)
FGF7
Human Genome Epidemiology (HuGE) Navigator
FGF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF7
genes like me logo Genes that share disorders with FGF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF7 Gene

Publications for FGF7 Gene

  1. Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. (PMID: 21565293) Teumer A … Völzke H (American journal of human genetics 2011) 3 45 60
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 45 60
  3. The effects of TGF-alpha, IL-1beta and PDGF on fibroblast adhesion to ECM-derived matrix and KGF gene expression. (PMID: 20036421) Wang X … Kao WJ (Biomaterials 2010) 3 22 60
  4. Modulation of calprotectin in human keratinocytes by keratinocyte growth factor and interleukin-1alpha. (PMID: 20065999) Bando M … Kido J (Immunology and cell biology 2010) 3 22 60
  5. Keratinocyte growth factor induces vascular endothelial growth factor-A expression in colorectal cancer cells. (PMID: 19148469) Narita K … Naito Z (International journal of oncology 2009) 3 22 60

Products for FGF7 Gene

Sources for FGF7 Gene

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