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FGF6 Gene

protein-coding   GIFtS: 66
GCID: GC12M004543

Fibroblast Growth Factor 6

  See FGF6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 61 2     HST-22 3
Heparin Secretory-Transforming Protein 22 3     HST22 3
Heparin-Binding Growth Factor 62 3     HSTF-22 3
FGF-62 3     HSTF23
HBGF-62 3     

External Ids:    HGNC: 36841   Entrez Gene: 22512   Ensembl: ENSG000001112417   OMIM: 1349215   UniProtKB: P107673   

Export aliases for FGF6 gene to outside databases

Previous GC identifers: GC12M004280 GC12M004435 GC12M004422 GC12M004413


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF6 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene
displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene
exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle
regeneration or differentiation. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF6 Gene:
FGF6 (fibroblast growth factor 6) is a protein-coding gene. Diseases associated with FGF6 include signet ring cell adenocarcinoma. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767
Function: Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and
myogenesis, and is required for normal muscle regeneration

Gene Wiki entry for FGF6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF6 gene promoter:
         SRF   SRF (504 AA)   MEF-2   LUN-1   Ik-3   N-Myc   MEF-2A   AREB6   aMEF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF6 promoter sequence
   Search Chromatin IP Primers for FGF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.32   HGNC cytogenetic band: 12p13

FGF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M004543:  view genomic region     (about GC identifiers)

Start:
4,537,321 bp from pter      End:
4,554,780 bp from pter
Size:
17,460 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767 (See protein sequence)
Recommended Name: Fibroblast growth factor 6 precursor  
Size: 208 amino acids; 22905 Da
Subunit: Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their
receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
Sequence caution: Sequence=CAA40359.1; Type=Erroneous initiation; Sequence=CAA40360.1; Type=Erroneous initiation;
Secondary accessions: Q0VAE1

Explore the universe of human proteins at neXtProt for FGF6: NX_P10767

Explore proteomics data for FGF6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn45

  • See FGF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066276.2  
    ENSEMBL proteins: 
     ENSP00000445479   ENSP00000228837  
    Reactome Protein details: P10767

    FGF6 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for FGF6
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FGF6

     
    Search eBioscience for Proteins for FGF6 

     
    antibodies-online proteins for FGF6 (8 products) 

     
    Search antibodies-online for peptides for FGF6

    FGF6 Antibody Products:

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    antibodies-online antibodies for FGF6 (24 products) 

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    Cloud-Clone Corp. ELISAs for FGF6
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    antibodies-online kits for FGF6 (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR028242 FGF6
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam

    Graphical View of Domain Structure for InterPro Entry P10767

    ProtoNet protein and cluster: P10767

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767
    Similarity: Belongs to the heparin-binding growth factors family


    Find genes that share domains with FGF6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF6_HUMAN, P10767
    Function: Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and
    myogenesis, and is required for normal muscle regeneration

         Genatlas biochemistry entry for FGF6:
    fibroblast growth factor 6,basic,HST oncogene homolog,expressed during embryonic development and in adult
    testis,heart,skeletal muscle,mitogenic for fibroblasts and endothelial cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IEA--
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with FGF6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FGF6:
     Increased cell death in breast 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fgf6):
     cellular  craniofacial  integument  muscle  normal 
     reproductive system  skeleton 

    Find genes that share phenotypes with FGF6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fgf6tm1Thbr for FGF6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF6

    miRNA
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    hsa-miR-19b hsa-miR-19a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FGF6
    Predesigned siRNA for gene silencing in human, mouse, rat FGF6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: FGF6 (NM_020996)
    Sino Biological Human cDNA Clone for FGF6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF6

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF6_HUMAN, P10767: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0042383sarcolemma IEA--

    Find genes that share ontologies with FGF6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF6 About   (see all 33)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR4 ligand binding and activation0.00
    SHC-mediated cascade0.79
    FGFR1 ligand binding and activation0.00
    FGFR2 ligand binding and activation0.74
    Activated point mutants of FGFR20.00
    FRS2-mediated cascade0.70
    Signaling by FGFR2 mutants0.00
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82


    Find genes that share SuperPaths with FGF6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF6 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF6
        Development FGF-family signaling

    2 BioSystems Pathways for FGF6
        Regulation of Actin Cytoskeleton
    Syndecan-4-mediated signaling events


    Selected Reactome Pathways for FGF6 (see all 14)
        Signaling by FGFR mutants
    PI3K Cascade
    FGFR2c ligand binding and activation
    Phospholipase C-mediated cascade
    Signaling by activated point mutants of FGFR1


    Selected Kegg Pathways  (Kegg details for FGF6) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF6: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Growth Factors in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for FGF6 (P107673 ENSP000002288374) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR4P224553, ENSP000002924084I2D: score=1 STRING: ENSP00000292408
    FGFR3P226073, ENSP000002607954I2D: score=1 STRING: ENSP00000260795
    FGFR1ENSP000003802804STRING: ENSP00000380280
    FGFR2ENSP000004102944STRING: ENSP00000410294
    FGF1ENSP000003385484STRING: ENSP00000338548
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0001525angiogenesis IEA--
    GO:0007165signal transduction TAS2649847
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007267cell-cell signaling TAS2649847

    Find genes that share ontologies with FGF6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF6

    1 HMDB Compound for FGF6    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    1 Novoseek inferred chemical compound relationship for FGF6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 23.2 3 8612679 (2), 7547864 (1)



    Find genes that share compounds with FGF6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGF6 gene: 
    NM_020996.1  

    Unigene Cluster for FGF6:

    Fibroblast growth factor 6
    Hs.166015  [show with all ESTs]
    Unigene Representative Sequence: BC121098
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535390 ENST00000543077 ENST00000228837(uc001qmr.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FGF6
      QuantiFast Probe-based Assays in human, mouse, rat FGF6

    Additional mRNA sequence: 

    BC121097.1 BC121098.1 X63454.1 

    1 DOTS entry:

    DT.40125292 

    4 AceView cDNA sequences:

    NM_020996 F22806 AA781411 X63454 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTCACTC
    FGF6 Expression
    About this image


    FGF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Cervical Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Cervical Hypaxial Myotome
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    FGF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.166015

    UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767
    Tissue specificity: Leukemia cell lines with platelet/ megakaryocytic differentiation potential

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF6: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Growth Factors in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FGF6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf61 , 5 fibroblast growth factor 61, 5 88.62(n)1
    93.27(a)1
      6 (61.92 cM)5
    141771  NM_010204.11  NP_034334.11 
     1270155425 
    chicken
    (Gallus gallus)
    Aves FGF61 fibroblast growth factor 6 65.21(n)
    67.48(a)
      768907  XM_001232070.2  XP_001232071.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF66
    fibroblast growth factor 6
    68(a)
    1 ↔ 1
    5(80995631-81005991)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fgf61 fibroblast growth factor 6 65.95(n)
    67.91(a)
      100217326  NM_001142823.1  NP_001136295.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf6b6
    fgf6a6
    fibroblast growth factor 6a
    64(a)
    63(a)
    1 ↔ many
    1 ↔ many
    4(5053899-5056586) ENSDARG00000045856
    25(17302404-17308946) ENSDARG00000009351


    ENSEMBL Gene Tree for FGF6 (if available)
    TreeFam Gene Tree for FGF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF6 gene
    FGF122  FGF162  FGF52  FGF202  FGF42  FGF92  FGF32  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    13 SIMAP similar genes for FGF6 using alignment to 2 protein entries:     FGF6_HUMAN (see all proteins):
    FGF4    FGF9    FGF13    FGF7    FGF12    FGF10
    FGF14    FGF16    FGF2    FGF5    FGF1    FGF20
    FGF3

    Find genes that share paralogs with FGF6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF6 (see all 322)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932525491,2
    Cuntested14474602(+) TGCCTA/G/TTCTCT 1 -- int10--------
    rs1811576901,2
    --4473256(+) CTGCCA/GTCTCT 1 -- ds50010--------
    rs171773951,2
    C,F--4473270(-) TGTCCT/CCAAAG 1 -- ds50013Minor allele frequency- C:0.02NS CSA WA 300
    rs1158064001,2
    C--4473361(+) GCACAC/TATCAA 1 -- ds50010--------
    rs1859878911,2
    --4473457(+) CCATTC/GCTCTG 1 -- ds50010--------
    rs1904012101,2
    --4473469(+) GAATGC/TGTATA 1 -- ds50010--------
    rs1841277701,2
    --4473524(+) CCTTTC/TCCTAT 1 -- ds50010--------
    rs1870445881,2
    --4473604(+) ATTGCC/TATTCT 1 -- ds50010--------
    rs171837921,2
    C,F--4473648(-) ACGGCA/GTGTAG 1 -- ds50012Minor allele frequency- G:0.02NS WA 298
    rs1910613681,2
    --4473661(+) GGTCCA/GGTGGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGF6 (4537321 - 4554780 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FGF6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv585CNV Loss18451855
    nsv898616CNV Gain21882294
    esv33276CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134921    OMIM disorders: --

    1 disease for FGF6:    
    About MalaCards
    signet ring cell adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for FGF6:
    Signet ring cell adenocarcinoma

    Find genes that share disorders with FGF6           About GenesLikeMe

    2 Novoseek inferred disease relationships for FGF6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 17.1 14 10945637 (7), 15613447 (1), 17697126 (1)
    tumors 0 1 1549352 (1)

    Genetic Association Database (GAD): FGF6
    Human Genome Epidemiology (HuGE) Navigator: FGF6 (1 document)
    Tumor Gene Database (TGDB): FGF6

    Export disorders for FGF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF6 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with FGF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization. (PubMed id 1549352)1, 2, 9 Iida S.... Terada M. (Oncogene 1992)
    2. Putative structure of the FGF6 gene product and role of the signal peptide. (PubMed id 1886714)1, 2, 9 Coulier F.... Birnbaum D. (Oncogene 1991)
    3. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 3 Zhang X....Ornitz D.M. (J. Biol. Chem. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)1, 2 Ornitz D.M.... Goldfarb M. (J. Biol. Chem. 1996)
    6. Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family. (PubMed id 2649847)1, 2 Marics I.... Birnbaum D. (Oncogene 1989)
    7. Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. (PubMed id 10945637)1, 9 Ropiquet F....Ittmann M. (Cancer Res. 2000)
    8. Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. (PubMed id 23263487)1 Jia W.H....Zheng W. (Nat. Genet. 2013)
    9. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    10. Common genetic variants associate with serum phosphorus concentration. (PubMed id 20558539)1 Kestenbaum B....Fox C.S. (J. Am. Soc. Nephrol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2251 HGNC: 3684 AceView: FGF6 Ensembl:ENSG00000111241 euGenes: HUgn2251
    ECgene: FGF6 Kegg: 2251 H-InvDB: FGF6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FGF6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF6 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF6 gene:
    Search GeneIP for patents involving FGF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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