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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF6 Gene

protein-coding   GIFtS: 64
GCID: GC12M004543

fibroblast growth factor 6
 Explore 10 diseases affiliated with
FGF6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FGF6    

Aliases
for FGF6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fibroblast Growth Factor 61 2     HST-22 3
Heparin Secretory-Transforming Protein 22 3     HST22 3
Heparin-Binding Growth Factor 62 3     HSTF-22 3
FGF-62 3     HSTF23
HBGF-62 3     

External Ids:    HGNC: 36841   Entrez Gene: 22512   Ensembl: ENSG000001112417   OMIM: 1349215   UniProtKB: P107673   

Export aliases for FGF6 gene to outside databases

Previous GC identifers: GC12M004280 GC12M004435 GC12M004422 GC12M004413


Summaries
for FGF6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FGF6:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess
broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including
embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed
oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a
restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or
differentiation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767
Function: Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and
myogenesis, and is required for normal muscle regeneration

Gene Wiki entry for FGF6


Genomic Views
for FGF6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF6 gene promoter:
         SRF   SRF (504 AA)   MEF-2   LUN-1   Ik-3   N-Myc   MEF-2A   AREB6   aMEF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGF6 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.32   HGNC cytogenetic band: 12p13

FGF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M004543:  view genomic region     (about GC identifiers)

Start:
 4,537,321 bp from pter      End:
 4,554,780 bp from pter
Size:
 17,460 bases      Orientation:
 minus strand

Proteins
for FGF6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767 (See protein sequence)
Recommended Name: Fibroblast growth factor 6 precursor  
Size: 208 amino acids; 22905 Da
Subunit: Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors
is increased by heparan sulfate glycosaminoglycans that function as coreceptors
Subcellular location: Secreted, extracellular space
Sequence caution: Sequence=CAA40359.1; Type=Erroneous initiation; Sequence=CAA40360.1; Type=Erroneous initiation;
Secondary accessions: Q0VAE1

Explore the universe of human proteins at neXtProt for FGF6: NX_P10767

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P10767

    • FGF6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066276.2  
    ENSEMBL proteins: 
     ENSP00000445479   ENSP00000228837  
    Reactome Protein details: P10767
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for FGF6 (FGF-6)
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    OriGene Protein Over-expression Lysate: FGF6
    OriGene Custom Protein Services for FGF6 
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    Novus Biologicals FGF6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FGF6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0042383sarcolemma IEA--


    FGF6 for ontologies           About GeneDecksing



    FGF6 Antibody Products: 
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    ThermoFisher Antibody for FGF6

    Assay Products for FGF6: 
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    Uscn ELISAs and CLIAs for FGF6

    Protein Domains /
    Families
    for FGF6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FGF6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry P10767

    ProtoNet protein and cluster: P10767

    2 Blocks protein families:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767
    Similarity: Belongs to the heparin-binding growth factors family


    Function
    for FGF6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767
    Function: Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and
    myogenesis, and is required for normal muscle regeneration

         Genatlas biochemistry entry for FGF6:
    fibroblast growth factor 6,basic,HST oncogene homolog,expressed during embryonic development and in adult
    testis,heart,skeletal muscle,mitogenic for fibroblasts and endothelial cells

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF6
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF6:
    hsa-miR-19b hsa-miR-19a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF6 (see all 7)
    OriGene shRNA RFP: FGF6
    OriGene siRNA: FGF6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FGF6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF6 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FGF6 (NM_020996)
    Sino Biological Human cDNA Clone for FGF6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF6 

    Cell Line
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    Search LifeMap BioReagents cell lines for FGF6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF6

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IEA--


    FGF6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FGF6:
     Increased cell death in breast 

    Animal Models:
         Mouse knock-out Fgf6tm1Thbr for FGF6
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fgf6):
     cellular  craniofacial  integument  muscle  normal 
     reproductive system  skeleton 

    FGF6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FGF6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2FGFR2c binds to FGF
    8/13 pathways (see all 13)
    		FGFR2c binds to FGF1.00
    		Signaling by activated point mutants of FGFR10.71
    		FGFR2c ligand binding and activation1.00
    		FGFR1 ligand binding and activation0.59
    		FGFR2 ligand binding and activation0.76
    		FGFR ligand binding and activation0.57
    		Signaling by FGFR2 mutants0.76
    		SHC-mediated cascade0.45
    3Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    4PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    5IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FGF6
        Development FGF-family signaling

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF6 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF6
        Development FGF-family signaling

    2 BioSystems Pathways for FGF6 
        Regulation of Actin Cytoskeleton
    Syndecan-4-mediated signaling events

    5/53        Reactome Pathways for FGF6 (see all 53)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    4         Kegg Pathways  (Kegg details for FGF6):
        MAPK signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Melanoma


    FGF6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/22 Interacting proteins for FGF6 (P107673 ENSP000002288374) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR4P224553, ENSP000002924084I2D: score=1 STRING: ENSP00000292408
    FGFR3P226073, ENSP000002607954I2D: score=1 STRING: ENSP00000260795
    FGFR1ENSP000003802804STRING: ENSP00000380280
    FGFR2ENSP000004102944STRING: ENSP00000410294
    FGF1ENSP000003385484STRING: ENSP00000338548
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0001525angiogenesis IEA--
    GO:0007165signal transduction TAS2649847
    GO:0007267cell-cell signaling TAS2649847
    GO:0008283cell proliferation TAS2649847


    FGF6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FGF6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF6

    1 HMDB Compound for FGF6    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--
    1 Novoseek chemical compound relationship for FGF6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 23.2 3 8612679 (2), 7547864 (1)

    Search CenterWatch for drugs/clinical trials and news about FGF6 

    Transcripts
    for FGF6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FGF6 gene: 
    NM_020996.1  

    Unigene Cluster for FGF6:

    Fibroblast growth factor 6
    Hs.166015  [show with all ESTs]
    Unigene Representative Sequence: BC121098
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535390 ENST00000543077 ENST00000228837(uc001qmr.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF6
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF6:
    hsa-miR-19b hsa-miR-19a
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF6 (see all 7)
    OriGene shRNA RFP: FGF6
    OriGene siRNA: FGF6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF6
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF6

    Additional cDNA sequence: 

    BC121097.1 BC121098.1 X63454.1 

    1 DOTS entry:

    DT.40125292 

    4 AceView cDNA sequences:

    AA781411 X63454 NM_020996 F22806 

    GeneLoc Exon Structure


    Expression
    for FGF6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTGTCACTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FGF6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteCervical Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FGF6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF6

    SOURCE GeneReport for Unigene cluster: Hs.166015

    UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767
    Tissue specificity: Leukemia cell lines with platelet/ megakaryocytic differentiation potential

        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF6: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Growth Factors in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF6

    Orthologs
    for FGF6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FGF6 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FGF61 fibroblast growth factor 6 65.21(n)
    67.48(a)    		   768907  XM_001232070.1  XP_001232071.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FGF66
    		 --
    		 71(a)
    		 1 ↔ 1
    		 5(80996324-81005988)
    zebrafish
    (Danio rerio)    		 Actinopterygii fgf6b6
    fgf6a6
    (see all 4)    		 fibroblast growth factor 6a
    (see all 4)    		 60(a)
    60(a)
    (see all 4)    		 1 ↔ many
    1 ↔ many
    (see all 4)    		 4(5053899-5056586)
    25(17302404-17308946)
    worm
    (Caenorhabditis elegans)    		 Secernentea let-7566
    		 Protein let-756
    		 13(a)
    		 1 → many
    		 III(6407076-6409965)


    ENSEMBL Gene Tree for FGF6 (if available)
    TreeFam Gene Tree for FGF6 (if available) 

    Paralogs
    for FGF6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF6 gene
    FGF122  FGF52  FGF202  FGF162  FGF42  FGF92  FGF32  FGF72  
    FGF112  FGF102  FGF222  FGF132  FGF142  
    13 SIMAP similar genes for FGF6 using alignment to 2 protein entries:     FGF6_HUMAN (see all proteins):
    FGF4    FGF9    FGF13    FGF7    FGF12    FGF10
    FGF14    FGF16    FGF2    FGF5    FGF1    FGF20
    FGF3

    FGF6 for paralogs           About GeneDecksing



    Genomic Variants
    for FGF6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FGF6
         1 CNV: 6985
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF6
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF6

    Disorders / Diseases
    for FGF6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FGF6 for disorders           About GeneDecksing

    OMIM gene information: 134921    OMIM disorders: --

    10 diseases for FGF6:    About MalaCards
    kaposi's sarcoma    prostate cancer    sarcoma    medulloblastoma
    prostatitis    breast cancer    melanoma    leukemia
    adenocarcinoma    pancreatitis

    2 Novoseek disease relationships for FGF6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 17.1 14 10945637 (7), 15613447 (1), 17697126 (1)
    tumors 0 1 1549352 (1)

    Human Genome Epidemiology (HuGE) Navigator: FGF6 (1 document)
    Tumor Gene Database (TGDB): FGF6

    Export disorders for FGF6 gene to outside databases

    Publications
    for FGF6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF6 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with FGF6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization. (PubMed id 1549352)1, 2, 9 Iida S.... Terada M. (1992)
    2. Putative structure of the FGF6 gene product and role of the signal peptide. (PubMed id 1886714)1, 2, 9 Coulier F.... Birnbaum D. (1991)
    3. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 3 Zhang X....Ornitz D.M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)1, 2 Ornitz D.M....Goldfarb M. (1996)
    6. Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family. (PubMed id 2649847)1, 2 Marics I.... Birnbaum D. (1989)
    7. Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. (PubMed id 10945637)1, 9 Ropiquet F....Ittmann M. (2000)
    8. Common genetic variants associate with serum phosphor us concentration. (PubMed id 20558539)1 Kestenbaum B....Fox C.S. (2010)
    9. Fibroblast growth factor signalling: from development to cancer. (PubMed id 20094046)2 Turner N. and Grose R. (2010)
    10. Regulation of osteoblast and osteoclast functions by FGF-6. (PubMed id 20458746)1 Bosetti M....Cannas M.F. (2010)

    External Searches for FGF6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FGF6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2251 HGNC: 3684 AceView: FGF6 Ensembl:ENSG00000111241 euGenes: HUgn2251
    ECgene: FGF6 Kegg: 2251 H-InvDB: FGF6

    Other Databases showing FGF6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FGF6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF6 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf6/

    Intellectual Property
    for FGF6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FGF6 gene:
    Search GeneIP for patents involving FGF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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