V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

FGF6 Gene

protein-coding   GIFtS: 59

GC12M004413
fibroblast growth factor 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
FGF-6 3
HBGF-6 2, 3
HST-2 3
HST2 2, 3
Descriptions
Heparin-binding growth factor 6 3
fibroblast growth factor 6 2
External Ids
HGNC: 36841
Entrez Gene: 22512
UniProtKB: P107673
Ensembl: ENSG000001112417
Search outside databases for aliases for FGF6 gene

Previous GC identifers: GC12M004280 GC12M004435 GC12M004422

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FGF6:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF
family members possess broad mitogenic and cell survival activities, and are involved in a variety
of biological processes, including embryonic development, cell growth, morphogenesis, tissue
repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when
transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression
profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or
differentiation. [provided by RefSeq]

UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767
Function: Can transform NIH 3T3 cells. Exhibits strong mitogenic and angiogenic properties

Gene Wiki entry for FGF6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FGF6 gene  

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.32   HGNC cytogenetic band: 12p13

FGF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M004413:     (about GC identifiers)

Start:
4,413,569 bp from pter
End:
4,425,041 bp from pter
Size:
11,473 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000012.10  NT_009759.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767 (See protein sequence)
Recommended Name: Fibroblast growth factor 6 precursor  
Size: 208 amino acids; 22905 Da
Subcellular location: Secreted, extracellular space
Secondary accessions: Q0VAE1

REFSEQ proteins: NP_066276.2  

ENSEMBL proteins: 
ENSP00000228837 


Human Recombinant Proteins 
Invitrogen human recombinant proteins for FGF6
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich Proteins for FGF6  
R&D Systems Recombinant & Natural Proteins for FGF6 (FGF-6)
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (FGF6)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region TAS2649847
About this table

Antibodies for FGF6: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
R&D Systems Antibodies for FGF6 (FGF-6)
Antibodies from Abcam (FGF6), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for FGF6

Assays for FGF6: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
R&D Systems ELISAs for FGF6 (FGF-6)         (see all)
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro domains/families:
 IPR002348 IL1_HBGF
 IPR002209 GF_heparin_bd


   GeneDecks  FGF6 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P10767

ProtoNet protein and cluster: P10767

2 Blocks protein families:
IPB002209 Heparin binding growth factor family signature
IPB002348 IL1/HBGF family signature


UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767
Similarity: Belongs to the heparin-binding growth factors family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (FGF6)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020996

              Applied Biosystems Silencer® siRNAs for FGF6

              Sigma-Aldrich siRNA and siRNA Panels for FGF6  
                     Sigma-Aldrich shRNA for FGF6  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020996
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020996
                                 untagged cDNA clone in CMV expression vector: NM_020996 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_020996

UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767
Function: Can transform NIH 3T3 cells. Exhibits strong mitogenic and angiogenic properties

Genatlas biochemistry entry for FGF6:
fibroblast growth factor 6,basic,HST oncogene homolog,expressed during embryonic development and in
adult testis,heart,skeletal muscle,mitogenic for fibroblasts and endothelial cells

7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fgf6):

cellularcraniofacialmusclenormalreproductive system
skeletonskin/coat/nails

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008083 growth factor activity TAS2649847
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Invitrogen iPath™ Online BioAtlas - Pathway for FGF6 (Maps provided by GeneGo):
 FGF-family signaling

   GeneDecks  FGF6 for the pathways selected above  
About GeneDecksing

1 Millipore Pathway for FGF6
 Development FGF-family signaling

   GeneDecks  FGF6 for the pathways selected above  
About GeneDecksing

4 Sigma-Aldrich "Your Favorite Gene" Pathways for  FGF6  (Your Favorite Gene powered by Ingenuity) 
 Actin Cytoskeleton Signaling
 Bladder Cancer Signaling
 FGF Signaling
 Clathrin-mediated Endocytosis

   GeneDecks  FGF6 for the pathways selected above  
About GeneDecksing

4 Kegg Pathways  (Kegg details for FGF6):
 hsa04010 MAPK signaling pathway
 hsa04810 Regulation of actin cytoskeleton
 hsa05200 Pathways in cancer
 hsa05218 Melanoma

   GeneDecks  FGF6 for the pathways selected above  
About GeneDecksing
 Gene Network CentralTM Interacting Genes and Proteins Network for  FGF6 


5/33 Interacting proteins for FGF6 (ENSP000002288373) via UniProtKB, MINT, and/or STRING (see all 33 )
InteractantInteraction Details
GeneCardExternal ID(s)
FGFR1ENSP000003113373STRING (score=.999)
FGFR2ENSP000003330903STRING (score=.999)
FGFR3ENSP000003541703STRING (score=.999)
FGFR4ENSP000003664123STRING (score=.999)
FGF19ENSP000002943123STRING (score=.924)
About this table

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0001502 cartilage condensation IEA--
GO:0001525 angiogenesis IEA--
GO:0007165 signal transduction TAS2649847
GO:0007267 cell-cell signaling TAS2649847
GO:0007275 multicellular organismal development IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FGF6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (FGF6)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020996

              Sigma-Aldrich siRNA and siRNA Panels for FGF6  
                     Sigma-Aldrich shRNA for FGF6  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_020996  

REFSEQ mRNAs for FGF6 gene: 

NM_020996.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_020996  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020996
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020996
                                 untagged cDNA clone in CMV expression vector: NM_020996 

Additional cDNA sequence: 

BC121097.1 BC121098.1 X63454.1 

1 DOTS entry:

DT.40125292 

4 AceView cDNA sequences:

AA781411 NM_020996 X63454 F22806 

highest scoring ESTs for FGF6:

X63454 NM_020996 AA781411 BC121097 BC121098 F22806 AI217705 

Unigene Cluster for FGF6:

Fibroblast growth factor 6
Hs.166015  [show with all ESTs]
Unigene Representative Sequence: BC121098


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000228837  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FGF6 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for FGF6

1 / 2 / 3

3 probe-sets matching FGF6 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

31928_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X63454 1.00 1.00 1.00 1

208417_at2, 3 U133-A 1 1.00 1.00 -- -- NM_020996 0.60 1.00 0.82 1

208417_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ACTGTCACTC

SOURCE GeneReport for Unigene cluster: Hs.166015

Expression variation in blood from EXPOLDB for FGF6

UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767
Tissue specificity: Leukemia cell lines with platelet/ megakaryocytic differentiation potential

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for FGF6 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
FGF61   -- fibroblast growth factor 6 92.15(n)
93.27(a)
486735  XM_862905.1  XP_867998.1 
chimpanzee
(Pan troglodytes)
FGF61   -- fibroblast growth factor 6 99.04(n)
99.04(a)
747181  XM_001157123.1  XP_001157123.1 
cow
(Bos taurus)
FGF61   -- fibroblast growth factor 6 89.9(n)
92.79(a)
540317  XM_593127.2  XP_593127.1 
rat
(Rattus norvegicus)
Fgf61   -- fibroblast growth factor 6 89.74(n)
93.75(a)
170700  NM_131908.1  NP_571983.1 
mouse
(Mus musculus)
Fgf61, 5 6 (61.10 cM)5
fibroblast growth factor 61, 5 88.62(n)1
93.27(a)1
141771  NM_010204.11  NP_034334.11 
 AK0865305  BC1402685  (see all 11)
About this table        Species with no ortholog for FGF6

ENSEMBL Gene Tree for FGF6
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for FGF6 gene
FGF132  FGF42  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/125 NCBI SNPs in FGF6 are shown (see all 125 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 67)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs116134951,2
A,C,F,H4424891(+) AGGGCA/GCCACC 1 V/A mis112Minor allele frequency- G:0.08NS EU EA WA NA 1336
rs73587831,2
A,C,F,H4426444(+) GTCGCT/CGGGGA 1 -- ng318Minor allele frequency- C:0.04NS EU EA WA NA 724
rs38128231,2
A,C,F,H4426897(+) TGAAAC/TCCTGT 1 -- ng3119Minor allele frequency- N:0.00EA NS NA EU WA 1614
rs29708231,2
C,F,H,O4425836(-) AATGTC/TGGGAC 1 -- ng3118Minor allele frequency- T:0.08NS NA EU EA WA 1812
rs29708241,2
A,C,F4425752(-) CATCCC/TCACCC 1 -- ng317Minor allele frequency- T:0.20NS 838
rs22412861,2
C,F,H4413622(-) AGGCTC/TACAGA 1 -- ut31 ese311Minor allele frequency- T:0.07NS EU EA WA 1240
rs79761801,2
A,F,H4426200(+) CTTCTA/GTATTT 1 -- ng314Minor allele frequency- G:0.01EU EA WA 420
rs29708221,2
C,F,H4426015(-) AGAAGT/CTCTGG 1 -- ng315Minor allele frequency- C:0.09NS EU EA WA 598
rs79770241,2
C,F,H4426912(+) CCCAGA/TTGTCT 1 -- ng317Minor allele frequency- T:0.04EU EA WA NA 558
rs79616451,2
C,F,H4413748(+) ACAAGT/ACTGAC 1 V/D mis1 ese324Minor allele frequency- A:0.04NS NA EU EA WA 1998
About this table

HapMap Linkage Disequilibrium images for FGF6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 134921

2 Novoseek disease relationships for FGF6 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer 19.19 14 10945637 (7), 15613447 (1), 17697126 (1)
tumors 0.00 1 1549352 (1)
About this table

Tumor Gene Database: FGF6

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/36 PubMed articles for FGF6 gene (see all 36 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2251 HGNC: 3684 AceView: FGF6 Ensembl:ENSG00000111241 euGenes: HUgn2251
ECgene: FGF6 H-InvDB: FGF6
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for FGF6 Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf6/
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for FGF6:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FGF6-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for FGF6 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Proteins for FGF6
 Lentivirus-delivered shRNAs for FGF6 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Search for Recombinant Proteins
 Search for Antibodies
 Search for Chimera RNAi
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(FGF6)
 Antibodies (FGF6)
 Search OriGene for FGF6
 Search Tocris compounds for FGF6




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for FGF6

GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
FGF6 Gene at Home site.
Version 2.41.1
server5.xennexinc.com