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Aliases for FGF6 Gene

Aliases for FGF6 Gene

  • Fibroblast Growth Factor 6 2 3
  • Heparin Secretory-Transforming Protein 2 3 4
  • Heparin-Binding Growth Factor 6 3 4
  • HBGF-6 3 4
  • HSTF-2 3 4
  • FGF-6 3 4
  • HST-2 3 4
  • HST2 3 4
  • HSTF2 4

External Ids for FGF6 Gene

Previous GeneCards Identifiers for FGF6 Gene

  • GC12M004280
  • GC12M004435
  • GC12M004422
  • GC12M004543

Summaries for FGF6 Gene

Entrez Gene Summary for FGF6 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF6 Gene

FGF6 (Fibroblast Growth Factor 6) is a Protein Coding gene. Diseases associated with FGF6 include signet ring cell adenocarcinoma and apert syndrome. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF6 Gene

  • Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.

Gene Wiki entry for FGF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF6 Gene

Genomics for FGF6 Gene

Regulatory Elements for FGF6 Gene

Genomic Location for FGF6 Gene

Start:
4,428,155 bp from pter
End:
4,445,614 bp from pter
Size:
17,460 bases
Orientation:
Minus strand

Genomic View for FGF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF6 Gene

Proteins for FGF6 Gene

  • Protein details for FGF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10767-FGF6_HUMAN
    Recommended name:
    Fibroblast growth factor 6
    Protein Accession:
    P10767
    Secondary Accessions:
    • Q0VAE1

    Protein attributes for FGF6 Gene

    Size:
    208 amino acids
    Molecular mass:
    22905 Da
    Quaternary structure:
    • Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
    SequenceCaution:
    • Sequence=CAA40359.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA40360.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FGF6 Gene

Proteomics data for FGF6 Gene at MOPED

Post-translational modifications for FGF6 Gene

  • Glycosylation at Asn45
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF6 Gene

Domains for FGF6 Gene

Gene Families for FGF6 Gene

HGNC:

Suggested Antigen Peptide Sequences for FGF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10767

UniProtKB/Swiss-Prot:

FGF6_HUMAN :
  • P10767
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF6: view

Function for FGF6 Gene

Molecular function for FGF6 Gene

GENATLAS Biochemistry: fibroblast growth factor 6,basic,HST oncogene homolog,expressed during embryonic development and in adult testis,heart,skeletal muscle,mitogenic for fibroblasts and endothelial cells
UniProtKB/Swiss-Prot Function: Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.

Gene Ontology (GO) - Molecular Function for FGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with FGF6: view
genes like me logo Genes that share phenotypes with FGF6: view

Animal Models for FGF6 Gene

MGI Knock Outs for FGF6:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FGF6 Gene

Localization for FGF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF6 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF6 Gene COMPARTMENTS Subcellular localization image for FGF6 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0042383 sarcolemma IEA --
genes like me logo Genes that share ontologies with FGF6: view

Pathways for FGF6 Gene

SuperPathways for FGF6 Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 PI-3K cascade
3 Signaling by FGFR
4 FGFR ligand binding and activation
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF6: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction TAS 2649847
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007267 cell-cell signaling TAS 2649847
genes like me logo Genes that share ontologies with FGF6: view

Compounds for FGF6 Gene

(1) HMDB Compounds for FGF6 Gene

Compound Synonyms Cas Number PubMed IDs
Heparin
  • Arteven
9005-49-6

(1) Novoseek inferred chemical compound relationships for FGF6 Gene

Compound -log(P) Hits PubMed IDs
heparin 23.2 3
genes like me logo Genes that share compounds with FGF6: view

Transcripts for FGF6 Gene

mRNA/cDNA for FGF6 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF6 Gene

Fibroblast growth factor 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF6 Gene

No ASD Table

Relevant External Links for FGF6 Gene

GeneLoc Exon Structure for
FGF6
ECgene alternative splicing isoforms for
FGF6

Expression for FGF6 Gene

mRNA expression in normal human tissues for FGF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF6 Gene

This gene is overexpressed in Muscle - Skeletal (50.3).

SOURCE GeneReport for Unigene cluster for FGF6 Gene Hs.166015

mRNA Expression by UniProt/SwissProt for FGF6 Gene

P10767-FGF6_HUMAN
Tissue specificity: Leukemia cell lines with platelet/ megakaryocytic differentiation potential
genes like me logo Genes that share expressions with FGF6: view

In Situ Assay Products

No data available for Protein expression for FGF6 Gene

Orthologs for FGF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF6 35
  • 99.04 (n)
  • 99.04 (a)
FGF6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGF6 35
  • 89.9 (n)
  • 92.79 (a)
FGF6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF6 35
  • 93.59 (n)
  • 95.67 (a)
FGF6 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf6 35
  • 88.62 (n)
  • 93.27 (a)
Fgf6 16
Fgf6 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGF6 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF6 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf6 35
  • 89.74 (n)
  • 93.75 (a)
chicken
(Gallus gallus)
Aves FGF6 35
  • 65.21 (n)
  • 67.48 (a)
FGF6 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF6 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf6 35
  • 65.95 (n)
  • 67.91 (a)
zebrafish
(Danio rerio)
Actinopterygii fgf6a 36
  • 63 (a)
OneToMany
fgf6b 36
  • 64 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.125 36
  • 24 (a)
OneToMany
Species with no ortholog for FGF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF6 Gene

ENSEMBL:
Gene Tree for FGF6 (if available)
TreeFam:
Gene Tree for FGF6 (if available)

Paralogs for FGF6 Gene

Paralogs for FGF6 Gene

Selected SIMAP similar genes for FGF6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGF6: view

Variants for FGF6 Gene

Sequence variations from dbSNP and Humsavar for FGF6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1019398 -- 4,435,898(-) AGCTG(C/T)TTCCC intron-variant
rs2193647 -- 4,442,648(-) TTCTT(C/T)CCAGC intron-variant
rs2241277 -- 4,444,357(-) TGGAT(A/G)GGGCA intron-variant
rs2241278 -- 4,444,352(-) GGGGC(A/G)ATGGA intron-variant
rs2241279 -- 4,444,217(-) TCCAC(C/T)GTGGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for FGF6 Gene

Variant ID Type Subtype PubMed ID
nsv898616 CNV Gain 21882294
nsv585 CNV Loss 18451855
esv33276 CNV Gain 17666407

Relevant External Links for FGF6 Gene

HapMap Linkage Disequilibrium report
FGF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF6 Gene

Disorders for FGF6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for FGF6 Gene including...

Search for FGF6 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FGF6 Gene

(2) Novoseek inferred disease relationships for FGF6 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 17.1 9
tumors 0 1

Relevant External Links for FGF6

Genetic Association Database (GAD)
FGF6
Human Genome Epidemiology (HuGE) Navigator
FGF6
Tumor Gene Database (TGDB):
FGF6
genes like me logo Genes that share disorders with FGF6: view

No data available for UniProtKB/Swiss-Prot for FGF6 Gene

Publications for FGF6 Gene

  1. Putative structure of the FGF6 gene product and role of the signal peptide. (PMID: 1886714) Coulier F. … Birnbaum D. (Oncogene 1991) 3 4 23
  2. Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization. (PMID: 1549352) Iida S. … Terada M. (Oncogene 1992) 3 4 23
  3. Receptor specificity of the fibroblast growth factor family. (PMID: 8663044) Ornitz D.M. … Goldfarb M. (J. Biol. Chem. 1996) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PMID: 16597617) Zhang X. … Ornitz D.M. (J. Biol. Chem. 2006) 2 3

Products for FGF6 Gene

Sources for FGF6 Gene

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