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Aliases & Descriptions for FGF6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FGF-6 3 | | HBGF-6 2, 3 | | HST-2 3 | | HST2 2, 3 |
| | | Descriptions |
|---|
| Heparin-binding growth factor 6 3 | | fibroblast growth factor 6 2 |
|
| | Search outside databases for aliases for FGF6 genePrevious GC identifers: GC12M004280 GC12M004435 GC12M004422 |
Summaries for FGF6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for FGF6: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq] UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767Function: Can transform NIH 3T3 cells. Exhibits strong mitogenic and angiogenic propertiesGene Wiki entry for FGF6 |
Genomic Location for FGF6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the FGF6 gene 
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.32 HGNC cytogenetic band: 12p13FGF6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M004413:
(about GC identifiers)
Start:
|
4,413,569 bp from pter |
End:
|
4,425,041 bp from pter |
Size:
|
11,473 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009759.15
| Proteins for FGF6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767 (See
protein sequence)Recommended Name: Fibroblast growth factor 6 precursor Size: 208 amino acids; 22905 Da
Subcellular location: Secreted, extracellular space
Secondary accessions: Q0VAE1REFSEQ proteins: NP_066276.2
ENSEMBL proteins: ENSP00000228837
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for FGF6: Assays for FGF6: | Protein
Domains/ Families for FGF6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P10767
ProtoNet protein and cluster: P10767 2 Blocks protein families: IPB002209 Heparin binding growth factor family signature IPB002348 IL1/HBGF family signature
UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767Similarity: Belongs to the heparin-binding growth factors family | Gene Function for FGF6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020996
Applied Biosystems Silencer® siRNAs for FGF6
Sigma-Aldrich siRNA and siRNA Panels for FGF6  Sigma-Aldrich shRNA for FGF6  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020996                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020996                                  untagged cDNA clone in CMV expression vector: NM_020996 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020996
UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767Function: Can transform NIH 3T3 cells. Exhibits strong mitogenic and angiogenic propertiesGenatlas biochemistry entry for FGF6:fibroblast growth factor 6,basic,HST oncogene homolog,expressed during embryonic development and in adult testis,heart,skeletal muscle,mitogenic for fibroblasts and endothelial cells7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Fgf6):
1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for FGF6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Sigma-Aldrich "Your Favorite Gene" Pathways for FGF6 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for FGF6 
5/33 Interacting proteins for FGF6 (ENSP000002288373) via UniProtKB, MINT, and/or STRING (see all 33
)About this table
5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9
): About this table
|
Drugs & Compounds for FGF6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for FGF6
|
Transcripts for FGF6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020996
Sigma-Aldrich siRNA and siRNA Panels for FGF6  Sigma-Aldrich shRNA for FGF6  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_020996 REFSEQ mRNAs for FGF6 gene: NM_020996.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020996               OriGene GFP tagged cDNA clone in CMV expression vector: NM_020996                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020996                                  untagged cDNA clone in CMV expression vector: NM_020996  Additional cDNA sequence: BC121097.1 BC121098.1 X63454.1 1 DOTS entry: DT.40125292 4 AceView cDNA sequences:AA781411 NM_020996 X63454 F22806
highest scoring ESTs for FGF6:X63454 NM_020996 AA781411 BC121097 BC121098 F22806 AI217705 Unigene Cluster for FGF6: Fibroblast growth factor 6 Hs.166015 [show with all ESTs]Unigene Representative Sequence: BC121098
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000228837
|
Expression for FGF6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FGF6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FGF6
1 / 2 / 3 3 probe-sets matching FGF6 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACTGTCACTC
SOURCE GeneReport for Unigene cluster: Hs.166015
Expression variation in blood from EXPOLDB for FGF6 UniProtKB/Swiss-Prot: FGF6_HUMAN, P10767Tissue specificity: Leukemia cell lines with platelet/ megakaryocytic differentiation potential |
Orthologs for FGF6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FGF6 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for FGF6
ENSEMBL Gene Tree for FGF6 | Paralogs for FGF6(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FGF6 gene
- FGF132 FGF42
|
SNPs/Variants for FGF6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FGF6 (up to first 250kb)
|
Disorders & Mutations for FGF6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 134921
2 Novoseek disease relationships for FGF6 gene
About this table
Tumor Gene Database: FGF6
|
Medical News for FGF6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FGF6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/36 PubMed articles for FGF6 gene (see all 36
):- Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization. (PubMed id 1549352)1, 3, 4 Iida S.... Terada M. (1992)
- Putative structure of the FGF6 gene product and role of the signal peptide. (PubMed id 1886714)1, 3, 4 Coulier F.... Birnbaum D. (1991)
- Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)2, 3 Zhang X....Ornitz D.M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family. (PubMed id 2649847)3, 4 Marics I.... Birnbaum D. (1989)
- Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. (PubMed id 10945637)1, 3 Ropiquet F....Ittmann M. (2000)
- Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. (PubMed id 17133345)3 Moffa A.B. and Ethier S.P. (2007)
- Functional phylogeny relates LET-756 to fibroblast growth factor 9. (PubMed id 15199049)3 Popovici C....Roubin R. (2004)
- Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor variant. (PubMed id 11801566)3 Duplan S.M....Kenigsberg R.L. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for FGF6
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FGF6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FGF6
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FGF6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for FGF6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FGF6:

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Incremental update: 13 Oct 2009
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