Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FGF5 Gene

protein-coding   GIFtS: 61
GCID: GC04P081187

Fibroblast Growth Factor 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fibroblast Growth Factor 51 2
Heparin-Binding Growth Factor 52 3
HBGF-52 3
Smag-822 3
FGF-53

External Ids:    HGNC: 36831   Entrez Gene: 22502   Ensembl: ENSG000001386757   OMIM: 1651905   UniProtKB: P120343   

Export aliases for FGF5 gene to outside databases

Previous GC identifers: GC04P081074 GC04P081473 GC04P081580 GC04P081646 GC04P081545 GC04P081406 GC04P076931


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FGF5 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene
was identified as an oncogene, which confers transforming potential when transfected into mammalian cells.
Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which
suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding
different isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF5 Gene:
FGF5 (fibroblast growth factor 5) is a protein-coding gene. Diseases associated with FGF5 include kaposi's sarcoma, and acquired immunodeficiency syndrome. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
Function: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for
normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression
from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By
similarity)

Gene Wiki entry for FGF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF5 gene promoter:
         AREB6   MEF-2   MyoD   CUTL1   Nkx2-5   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF5 promoter sequence
   Search Chromatin IP Primers for FGF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21

FGF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P081187:  view genomic region     (about GC identifiers)

Start:
81,187,742 bp from pter      End:
81,257,834 bp from pter
Size:
70,093 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034 (See protein sequence)
Recommended Name: Fibroblast growth factor 5 precursor  
Size: 268 amino acids; 29551 Da
Subunit: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is
increased by heparan sulfate glycosaminoglycans that function as coreceptors
Developmental stage: Can transform NIH 3T3 cells
Sequence caution: Sequence=AAB60698.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R554 O75846 Q3Y8M3 Q8NF90
Alternative splicing: 2 isoforms:  P12034-1   P12034-2   (Seems to have an antagonistic effect compared to that of the isoform Long)

Explore the universe of human proteins at neXtProt for FGF5: NX_P12034

Explore proteomics data for FGF5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn110
  • Modification sites at PhosphoSitePlus

  • See FGF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004455.2  NP_149134.1  

    ENSEMBL proteins: 
     ENSP00000311697   ENSP00000398353   ENSP00000423903  
    Reactome Protein details: P12034

    FGF5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FGF5 (FGF-5)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FGF5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FGF5
    GenScript Custom Purified and Recombinant Proteins Services for FGF5
    Novus Biologicals FGF5 Proteins
    Novus Biologicals FGF5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FGF5

    FGF5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FGF5 (FGF-5)
    OriGene Antibodies for FGF5
    OriGene Custom Antibody Services for FGF5
    Novus Biologicals FGF5 Antibodies
    Abcam antibodies for FGF5
    Cloud-Clone Corp. Antibodies for FGF5
    Search ThermoFisher Antibodies for FGF5
    LSBio Antibodies in human, mouse, rat for FGF5

    FGF5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FGF5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FGF5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF5
    Cloud-Clone Corp. CLIAs for FGF5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR028240 FGF5
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam

    Graphical View of Domain Structure for InterPro Entry P12034

    ProtoNet protein and cluster: P12034

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
    Similarity: Belongs to the heparin-binding growth factors family


    FGF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF5_HUMAN, P12034
    Function: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for
    normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression
    from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By
    similarity)

         Genatlas biochemistry entry for FGF5:
    fibroblast growth factor 5,basic,HST oncogene homolog,expressed by fibroblasts,epithelium and during embryonic
    development mitogenic for fibroblast

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IDA8386828
    GO:0008083growth factor activity IEA--
         
    FGF5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 6 alleles(MGI details for Fgf5):
     integument 

    FGF5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fgf5tm1Mrt for FGF5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF5

    miRNA
    Products:
        
    miRTarBase miRNAs that target FGF5:
    hsa-mir-15b-5p (MIRT046529), hsa-mir-124-3p (MIRT022485)

    Block miRNA regulation of human, mouse, rat FGF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF5 (see all 80):
    hsa-miR-548j hsa-miR-3678-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-376b hsa-miR-106a hsa-miR-374a hsa-miR-138-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FGF5
    Predesigned siRNA for gene silencing in human, mouse, rat FGF5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FGF5

    Clone
    Products:
         
    OriGene clones in human, mouse for FGF5 (see all 12)
    OriGene ORF clones in mouse, rat for FGF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FGF5 (NM_004464)
    Sino Biological Human cDNA Clone for FGF5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FGF5
    Browse ESI BIO Cell Lines and PureStem Progenitors for FGF5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FGF5_HUMAN, P12034: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytoskeleton1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9786939

    FGF5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FGF5 About   (see all 32)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    4Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    5FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR1 ligand binding and activation0.00
    SHC-mediated cascade0.79
    Activated point mutants of FGFR20.00
    FGFR2 ligand binding and activation0.74
    Signaling by FGFR2 mutants0.00
    FRS2-mediated cascade0.70
    FGFR2c ligand binding and activation0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF5 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for FGF5
        Regulation of Actin Cytoskeleton


    Selected Reactome Pathways for FGF5 (see all 16)
        PI3K Cascade
    Signaling by FGFR mutants
    FGFR2c ligand binding and activation
    Phospholipase C-mediated cascade
    Signaling by activated point mutants of FGFR1


    Selected Kegg Pathways  (Kegg details for FGF5) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton


    FGF5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF5: 
              Notch Signaling Targets in human mouse rat
              Growth Factors in human mouse rat
              Cell Lineage Identification in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for FGF5 (P120343 ENSP000003116974) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR3P226073, ENSP000002607954I2D: score=1 STRING: ENSP00000260795
    FGFR4P224553, ENSP000002924084I2D: score=1 STRING: ENSP00000292408
    EGFRENSP000002754934STRING: ENSP00000275493
    IGF1RENSP000002680354STRING: ENSP00000268035
    METENSP000003172724STRING: ENSP00000317272
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007267cell-cell signaling TAS9786939
    GO:0007399nervous system development TAS9786939
    GO:0008283cell proliferation TAS3211147
    GO:0008284positive regulation of cell proliferation IGI8663044

    FGF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF5

    1 HMDB Compound for FGF5    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    5 Novoseek inferred chemical compound relationships for FGF5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidine 10.3 1 8394679 (1)
    vegf 9.36 3 17161616 (1), 19450457 (1)
    heparin 4.52 4 8386828 (1), 11876253 (1), 7547864 (1)
    tyrosine 0 1 9786939 (1)
    gold 0 1 9134330 (1)



    FGF5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FGF5 gene (2 alternative transcripts): 
    NM_004464.3  NM_033143.2  

    Unigene Cluster for FGF5:

    Fibroblast growth factor 5
    Hs.37055  [show with all ESTs]
    Unigene Representative Sequence: NM_004464
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312465 ENST00000456523(uc003hmd.3 uc003hme.3) ENST00000380628
    ENST00000507780 ENST00000503413
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FGF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF5 (see all 80):
    hsa-miR-548j hsa-miR-3678-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-376b hsa-miR-106a hsa-miR-374a hsa-miR-138-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FGF5
    Predesigned siRNA for gene silencing in human, mouse, rat FGF5
    Clone
    Products:
         
    OriGene clones in human, mouse for FGF5 (see all 12)
    OriGene ORF clones in mouse, rat for FGF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FGF5 (NM_004464)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FGF5
    OriGene qSTAR qPCR primer pairs in human, mouse for FGF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF5
      QuantiTect SYBR Green Assays in human, mouse, rat FGF5
      QuantiFast Probe-based Assays in human, mouse, rat FGF5

    Additional mRNA sequence: 

    AB016517.1 AF171928.1 AF355187.1 AF535149.1 AK090557.1 AK291962.1 AK312065.1 BC074858.2 
    BC074859.2 BC131502.1 M37825.1 

    4 DOTS entries:

    DT.95153354  DT.209995  DT.99932759  DT.102822933 

    Selected AceView cDNA sequences (see all 26):

    N33833 AK090557 BC074859 BC074858 AI082077 AA373315 CA487169 BQ773933 
    AL702742 NM_004464 AF535149 NM_033143 N24958 AA373379 M37825 BG169736 
    BQ001160 AA373667 AF171928 AB016517 AF355187 AW168314 AA461028 BQ018239 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FGF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FGF5 Expression
    About this image


    FGF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 6 entries
             Early Epiblast Cells Epiblast
             Epiblast Stem Cells
             Epiblast-like cells
     
     Eye (Sensory Organs)
             Anterior neural specified EBs
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    FGF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37055

    UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
    Tissue specificity: Expressed in neonatal brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF5: 
              Notch Signaling Targets in human mouse rat
              Growth Factors in human mouse rat
              Cell Lineage Identification in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FGF5
    OriGene qSTAR qPCR primer pairs in human, mouse for FGF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF5
    QuantiTect SYBR Green Assays in human, mouse, rat FGF5
    QuantiFast Probe-based Assays in human, mouse, rat FGF5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FGF5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf51 , 5 fibroblast growth factor 51, 5 84.08(n)1
    87.04(a)1
      5 (47.77 cM)5
    141761  NM_010203.51  NP_034333.11 
     982541845 
    chicken
    (Gallus gallus)
    Aves FGF51 fibroblast growth factor 5 65.45(n)
    71.2(a)
      770457  XM_001233790.3  XP_001233791.2 
    lizard
    (Anolis carolinensis)
    Reptilia FGF56
    fibroblast growth factor 5
    69(a)
    1 ↔ 1
    GL343425.1(424005-456815)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fgf51 fibroblast growth factor 5 73.47(n)
    77.04(a)
      100486176  XM_002934009.2  XP_002934055.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf51 fibroblast growth factor 5 66.31(n)
    70.27(a)
      494454  NM_001009561.1  NP_001009561.1 


    ENSEMBL Gene Tree for FGF5 (if available)
    TreeFam Gene Tree for FGF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FGF5 gene
    FGF122  FGF162  FGF202  FGF42  FGF62  FGF92  FGF32  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    15 SIMAP similar genes for FGF5 using alignment to 2 protein entries:     FGF5_HUMAN (see all proteins):
    FGF20    KGFLP1    PRED3    FGF7    FGF22    FGF16
    FGF10    FGF9    FGF11    FGF14    FGF3    FGF6
    FGF1    FGF2    FGF4

    FGF5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FGF5 (see all 640)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1855424491,2
    --81004757(+) GGAACA/CACTCT 2 -- us2k10--------
    rs170048571,2
    C,F,H--81004837(+) TCTTCG/ATCACT 2 -- us2k127Minor allele frequency- A:0.06NA NS EA WA 2476
    rs287182381,2
    C,F--81004861(+) GTGTAT/CTTGCG 2 -- us2k17Minor allele frequency- C:0.04NS WA 310
    rs174662891,2
    C,F,H--81004896(+) CATTCA/GGCAGC 2 -- us2k120Minor allele frequency- G:0.05NA NS EA 1648
    rs1508250491,2
    --81004946(+) TCAGGG/TCATTG 2 -- us2k10--------
    rs38067511,2
    C,F--81005005(+) TCCCCA/GGAAGA 2 -- us2k10--------
    rs353208471,2
    C,F--81005031(+) AGTAGA/GCCATT 2 -- us2k16Minor allele frequency- G:0.02NS WA 308
    rs356143881,2
    F--81005105(+) CCCACC/TCTAGT 2 -- us2k15Minor allele frequency- T:0.01NS 190
    rs340503301,2
    C,F--81005118(+) AGGGAG/AAAGTA 2 -- us2k16Minor allele frequency- A:0.06NS NA 310
    rs1161766361,2
    F--81005146(+) ACAGTG/AGACAG 2 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for FGF5 (81187742 - 81257834 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FGF5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF5
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 165190    OMIM disorders: --

    Selected diseases for FGF5 (see all 22):    
    About MalaCards
    kaposi's sarcoma    acquired immunodeficiency syndrome    choroiditis    glioblastoma multiforme
    pancreatic cancer    sarcoma    ischemia    periodontitis
    pancreatitis    renal cell carcinoma    melanoma    adenocarcinoma
    esophagitis    hypertension    retinitis    rheumatoid arthritis
    arthritis    ovarian cancer    endotheliitis    breast cancer


    FGF5 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for FGF5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kaposi sarcoma 45.6 3 1987771 (3)
    carcinoma renal cell 25.8 4 11454700 (1), 8616814 (1), 14724640 (1)
    gastric cancer 20.7 1 7511892 (1)
    pancreatic cancer 20.4 6 9333017 (4), 11876253 (1)
    tumors 5.04 7 2005884 (1), 8374885 (1), 1716514 (1), 1992446 (1) (see all 5)
    myocardial ischemia 0 3 8616711 (1), 16149904 (1)
    adenocarcinoma 0 3 11454700 (2), 8334620 (1)
    melanoma 0 1 1716514 (1)
    cancer 0 4 11454700 (1), 9333017 (1), 14724640 (1)

    Genetic Association Database (GAD): FGF5
    Human Genome Epidemiology (HuGE) Navigator: FGF5 (9 documents)
    Tumor Gene Database (TGDB): FGF5

    Export disorders for FGF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FGF5 gene, integrated from 10 sources (see all 103):
    (articles sorted by number of sources associating them with FGF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. (PubMed id 3211147)1, 2, 3 Zhan X.... Goldfarb M. (Mol. Cell. Biol. 1988)
    2. Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. (PubMed id 1700424)1, 2, 9 Haub O.... Goldfarb M. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    3. Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas. (PubMed id 11454700)1, 2, 9 Hanada K.-I....Yang J.C. (Cancer Res. 2001)
    4. Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes. (PubMed id 10823842)1, 2, 9 de Vries C.J.M.... Pannekoek H. (J. Biol. Chem. 2000)
    5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    6. Confirmation of top polymorphisms in hypertension genome wide association study among Han Chinese. (PubMed id 20542020)1, 4 Niu W....Zhu D. ( international journal of clinical chemistry 2010)
    7. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    8. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    9. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PubMed id 20479155)1, 4 Takeuchi F....Kato N. (Circulation 2010)
    10. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (Nat. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2250 HGNC: 3683 AceView: FGF5 Ensembl:ENSG00000138675 euGenes: HUgn2250
    ECgene: FGF5 Kegg: 2250 H-InvDB: FGF5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FGF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FGF5 gene:
    Search GeneIP for patents involving FGF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for FGF5 (FGF-5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FGF5 (FGF-5)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FGF5   OriGene RNAi products in human, mouse, rat for FGF5  
     OriGene qPCR primer pairs and template standards for FGF5   OriGene Protein Over-expression Lysate for FGF5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FGF5  
     OriGene qSTAR qPCR primer pairs in human, mouse for FGF5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FGF5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FGF5   OriGene Custom Protein Services for FGF5  

     
     
     Block miRNA regulation of human, mouse, rat FGF5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FGF5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF5 Predesigned siRNA for gene silencing in human, mouse, rat FGF5
     QuantiFast Probe-based Assays in human, mouse, rat FGF5 QuantiTect SYBR Green Assays in human, mouse, rat FGF5
     PCR Arrays including human, mouse, rat FGF5 Search Chromatin IP Primers for FGF5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF5  GeneGlobe Interaction Network for FGF5
     Regulatory tfbs in FGF5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FGF5 GenScript cDNA clones with any tag delivered in your preferred vector for FGF5
     GenScript Custom Assay Services for FGF5 GenScript Custom overexpressing Cell Line Services for FGF5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FGF5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FGF5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FGF5 antibodies
     FGF5 proteins
     FGF5 lysates
     Antibodies for FGF5
     See all of Abcam's Antibodies, Kits and Proteins for FGF5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FGF5
     Antibodies for FGF5
     ELISAs for FGF5
     CLIAs for FGF5



     Browse ESI BIO Cell Lines and PureStem Progenitors for FGF5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FGF5
     SwitchGear Promoter luciferase reporter plasmids for FGF5
     Search ThermoFisher Antibodies for FGF5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF5
     LSBio Antibodies in human, mouse, rat for FGF5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FGF5 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4