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Aliases for FGF5 Gene

Aliases for FGF5 Gene

  • Fibroblast Growth Factor 5 2 3 5
  • Heparin-Binding Growth Factor 5 3 4
  • Smag-82 3 4
  • HBGF-5 3 4
  • TCMGLY 3
  • FGF-5 4

External Ids for FGF5 Gene

Previous GeneCards Identifiers for FGF5 Gene

  • GC04P081074
  • GC04P081473
  • GC04P081580
  • GC04P081646
  • GC04P081545
  • GC04P081406
  • GC04P081187
  • GC04P076931

Summaries for FGF5 Gene

Entrez Gene Summary for FGF5 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF5 Gene

FGF5 (Fibroblast Growth Factor 5) is a Protein Coding gene. Diseases associated with FGF5 include Trichomegaly and Hereditary Spherocytosis. Among its related pathways are RET signaling and Negative regulation of FGFR3 signaling. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF3.

UniProtKB/Swiss-Prot for FGF5 Gene

  • Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).

Gene Wiki entry for FGF5 Gene

Additional gene information for FGF5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF5 Gene

Genomics for FGF5 Gene

GeneHancer (GH) Regulatory Elements for FGF5 Gene

Promoters and enhancers for FGF5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I080264 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 732 5.7 PKNOX1 POLR2B GLIS2 FOS ATF7 ZNF202 SP3 REST GMEB1 SMARCA4 GC04M080267 FGF5 MRPS25P1
GH04I080234 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.6 -28.4 -28379 7.1 MEIS2 PKNOX1 FOXA2 JUN BMI1 POLR2A ADNP ATF7 FOSL2 ETV6 GC04M080238 FGF5 GC04M080167 GC04M080195
GH04I080171 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -93.8 -93792 3.2 FOSL1 GATA3 HMBOX1 TRIM24 ETV6 IKZF2 RUNX3 ANTXR2 PRDM8 FGF5 RPSAP39 GC04M080167
GH04I080213 Enhancer 0.5 ENCODE dbSUPER 11 -53.2 -53160 0.6 PRDM1 LOC105377303 PRDM8 FGF5 GC04M080195 GC04M080238 GC04M080167
GH04I080292 Enhancer 0.4 dbSUPER 11.5 +28.8 28831 6.6 ZFHX2 POLR2A SCRT2 C4orf22 FGF5 BMP3 MRPS25P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FGF5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FGF5 gene promoter:

Genomic Locations for FGF5 Gene

Genomic Locations for FGF5 Gene
70,093 bases
Plus strand

Genomic View for FGF5 Gene

Genes around FGF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF5 Gene

Proteins for FGF5 Gene

  • Protein details for FGF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibroblast growth factor 5
    Protein Accession:
    Secondary Accessions:
    • B2R554
    • O75846
    • Q3Y8M3
    • Q8NF90

    Protein attributes for FGF5 Gene

    268 amino acids
    Molecular mass:
    29551 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
    • Sequence=AAB60698.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FGF5 Gene


neXtProt entry for FGF5 Gene

Post-translational modifications for FGF5 Gene

Other Protein References for FGF5 Gene

No data available for DME Specific Peptides for FGF5 Gene

Domains & Families for FGF5 Gene

Gene Families for FGF5 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FGF5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heparin-binding growth factors family.
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF5: view

Function for FGF5 Gene

Molecular function for FGF5 Gene

GENATLAS Biochemistry:
fibroblast growth factor 5,basic,HST oncogene homolog,expressed by fibroblasts,epithelium and during embryonic development mitogenic for fibroblast
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).

Phenotypes From GWAS Catalog for FGF5 Gene

Gene Ontology (GO) - Molecular Function for FGF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IDA,IEA 8386828
GO:0008083 growth factor activity IEA --
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS --
genes like me logo Genes that share ontologies with FGF5: view
genes like me logo Genes that share phenotypes with FGF5: view

Human Phenotype Ontology for FGF5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGF5 Gene

MGI Knock Outs for FGF5:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF5 Gene

Localization for FGF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF5 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FGF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space TAS 9786939
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with FGF5: view

Pathways & Interactions for FGF5 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Apoptotic Pathways in Synovial Fibroblasts
4 Negative regulation of FGFR3 signaling
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF5: view

SIGNOR curated interactions for FGF5 Gene


Gene Ontology (GO) - Biological Process for FGF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007267 cell-cell signaling TAS 9786939
GO:0007399 nervous system development TAS 9786939
GO:0008283 cell proliferation TAS 3211147
GO:0008284 positive regulation of cell proliferation IGI 8663044
genes like me logo Genes that share ontologies with FGF5: view

Drugs & Compounds for FGF5 Gene

(3) Drugs for FGF5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 905,282

(2) Additional Compounds for FGF5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF5: view

Transcripts for FGF5 Gene

Unigene Clusters for FGF5 Gene

Fibroblast growth factor 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF5 Gene

No ASD Table

Relevant External Links for FGF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF5 Gene

This gene is overexpressed in Brain - Cerebellum (x6.1) and Brain - Cerebellar Hemisphere (x6.0).

Protein differential expression in normal tissues from HIPED for FGF5 Gene

This gene is overexpressed in Platelet (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF5 Gene

Protein tissue co-expression partners for FGF5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGF5 Gene:


SOURCE GeneReport for Unigene cluster for FGF5 Gene:


mRNA Expression by UniProt/SwissProt for FGF5 Gene:

Tissue specificity: Expressed in neonatal brain.

Evidence on tissue expression from TISSUES for FGF5 Gene

  • Nervous system(4.4)
  • Lung(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF5 Gene

Germ Layers:
  • ectoderm
  • integumentary
  • nervous
Head and neck:
  • eye
  • eyelid
  • face
  • head
  • hair
  • skin
genes like me logo Genes that share expression patterns with FGF5: view

Orthologs for FGF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FGF5 33 34
  • 99.5 (n)
(Bos Taurus)
Mammalia FGF5 33 34
  • 89.38 (n)
(Ornithorhynchus anatinus)
Mammalia FGF5 34
  • 88 (a)
(Canis familiaris)
Mammalia FGF5 33 34
  • 86.45 (n)
(Rattus norvegicus)
Mammalia Fgf5 33
  • 85.41 (n)
(Mus musculus)
Mammalia Fgf5 33 16 34
  • 84.08 (n)
(Monodelphis domestica)
Mammalia FGF5 34
  • 81 (a)
(Gallus gallus)
Aves FGF5 33 34
  • 65.45 (n)
(Anolis carolinensis)
Reptilia FGF5 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf5 33
  • 73.47 (n)
(Danio rerio)
Actinopterygii fgf5 33 34
  • 66.31 (n)
Species where no ortholog for FGF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF5 Gene

Gene Tree for FGF5 (if available)
Gene Tree for FGF5 (if available)

Paralogs for FGF5 Gene

Paralogs for FGF5 Gene

(15) SIMAP similar genes for FGF5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGF5: view

Variants for FGF5 Gene

Sequence variations from dbSNP and Humsavar for FGF5 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs587777579 pathogenic, Trichomegaly 80,275,013(+) G/ intron_variant, splice_donor_variant
rs587777580 pathogenic, Trichomegaly 80,266,983(+) TAT/T coding_sequence_variant, frameshift, genic_upstream_transcript_variant, upstream_transcript_variant
rs587777581 pathogenic, Trichomegaly, Trichomegaly (TCMGLY) [MIM:190330] 80,286,385(+) T/C/G 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000166696 -- 80,280,966(+) A/G intron_variant
rs1000224671 -- 80,283,944(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FGF5 Gene

Variant ID Type Subtype PubMed ID
esv3893966 CNV loss 25118596

Variation tolerance for FGF5 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGF5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF5 Gene

Disorders for FGF5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FGF5 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • tcmgly
hereditary spherocytosis
  • congenital spherocytic hemolytic anemia
- elite association - COSMIC cancer census association via MalaCards
Search FGF5 in MalaCards View complete list of genes associated with diseases


  • Trichomegaly (TCMGLY) [MIM:190330]: A morphologic trait characterized by unusually long eyelashes and mild hypertrichosis of eyebrows. It can be observed in association with corneal irritation, cataracts, and hereditary spherocytosis. {ECO:0000269 PubMed:24989505}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for FGF5

Genetic Association Database
Human Genome Epidemiology Navigator
Tumor Gene Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FGF5: view

No data available for Genatlas for FGF5 Gene

Publications for FGF5 Gene

  1. Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas. (PMID: 11454700) Hanada K … Yang JC (Cancer research 2001) 3 4 22 58
  2. Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes. (PMID: 10823842) de Vries CJ … Pannekoek H (The Journal of biological chemistry 2000) 3 4 22 58
  3. Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. (PMID: 1700424) Haub O … Goldfarb M (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 22 58
  4. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. (PMID: 3211147) Zhan X … Goldfarb M (Molecular and cellular biology 1988) 2 3 4 58
  5. FGF5 is a crucial regulator of hair length in humans. (PMID: 24989505) Higgins CA … Christiano AM (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4 58

Products for FGF5 Gene

Sources for FGF5 Gene

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