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FGF5 Gene

protein-coding   GIFtS: 60

GC04P081406
fibroblast growth factor 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
FGF-5 3
HBGF-5 2, 3
Smag-82 2, 3
Descriptions
Heparin-binding growth factor 5 2, 3
fibroblast growth factor 5 2
External Ids
HGNC: 36831
Entrez Gene: 22502
UniProtKB: P120343
Ensembl: ENSG000001386757
Search outside databases for aliases for FGF5 gene

Previous GC identifers: GC04P081074 GC04P081473 GC04P081580 GC04P081646 GC04P081545

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FGF5:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF
family members possess broad mitogenic and cell survival activities, and are involved in a variety
of biological processes, including embryonic development, cell growth, morphogenesis, tissue
repair, tumor growth and invasion. This gene was identified as an oncogene, which confers
transforming potential when transfected into mammalian cells. Targeted disruption of the homolog
of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a
function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding
different isoforms have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
Function: Functions as an inhibitor of hair elongation by promoting progression from anagen, the
growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By
similarity)

Gene Wiki entry for FGF5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FGF5 gene  

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21

FGF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P081406:     (about GC identifiers)

Start:
81,406,766 bp from pter
End:
81,431,195 bp from pter
Size:
24,430 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000004.10  NT_016354.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034 (See protein sequence)
Recommended Name: Fibroblast growth factor 5 precursor  
Size: 268 amino acids; 29551 Da
Subcellular location: Secreted (Potential)
Developmental stage: Can transform NIH 3T3 cells
Secondary accessions: O75846 Q3Y8M3
Alternative splicing: 2 isoforms:  P12034-1   P12034-2   

REFSEQ proteins (2 alternative transcripts): 
NP_004455.2  NP_149134.1  


ENSEMBL proteins: 
ENSP00000350269 ENSP00000370002 ENSP00000311697 


Human Recombinant Proteins 
Invitrogen human recombinant proteins for FGF5
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich Proteins for FGF5  
R&D Systems Recombinant & Natural Proteins for FGF5 (FGF-5)
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (FGF5)
Human Recombinant Proteins from Abnova (FGF5)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005615 extracellular space TAS9786939
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Antibodies for FGF5: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for FGF5
R&D Systems Antibodies for FGF5 (FGF-5)
Antibodies from Abcam (FGF5), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (FGF5)
Novus Biologicals Antibody for FGF5

Assays for FGF5: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro domains/families:
 IPR002348 IL1_HBGF
 IPR002209 GF_heparin_bd


   GeneDecks  FGF5 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P12034

ProtoNet protein and cluster: P12034

2 Blocks protein families:
IPB002209 Heparin binding growth factor family signature
IPB002348 IL1/HBGF family signature


UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
Similarity: Belongs to the heparin-binding growth factors family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (FGF5)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_033143

              Applied Biosystems Silencer® siRNAs for FGF5

              Sigma-Aldrich siRNA and siRNA Panels for FGF5  
                     Sigma-Aldrich shRNA for FGF5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for FGF5
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004464
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004464
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_004464 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_004464

UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
Function: Functions as an inhibitor of hair elongation by promoting progression from anagen, the
growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By
similarity)

Genatlas biochemistry entry for FGF5:
fibroblast growth factor 5,basic,HST oncogene homolog,expressed by fibroblasts,epithelium and
during embryonic development mitogenic for fibroblast

2 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Fgf5):

skin/coat/nailstouch/vibrissae

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008083 growth factor activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


4 Sigma-Aldrich "Your Favorite Gene" Pathways for  FGF5  (Your Favorite Gene powered by Ingenuity) 
 Actin Cytoskeleton Signaling
 Clathrin-mediated Endocytosis
 Bladder Cancer Signaling
 FGF Signaling

   GeneDecks  FGF5 for the pathways selected above  
About GeneDecksing

4 Kegg Pathways  (Kegg details for FGF5):
 hsa04010 MAPK signaling pathway
 hsa04810 Regulation of actin cytoskeleton
 hsa05200 Pathways in cancer
 hsa05218 Melanoma

   GeneDecks  FGF5 for the pathways selected above  
About GeneDecksing
 Gene Network CentralTM Interacting Genes and Proteins Network for  FGF5 


5/34 Interacting proteins for FGF5 (ENSP000003116973) via UniProtKB, MINT, and/or STRING (see all 34 )
InteractantInteraction Details
GeneCardExternal ID(s)
FGFR3ENSP000003541703STRING (score=.999)
FGFR4ENSP000003664123STRING (score=.999)
FGFR1ENSP000003113373STRING (score=.995)
FGFR2ENSP000003330903STRING (score=.985)
FGF8ENSP000003217973STRING (score=.924)
About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007267 cell-cell signaling TAS9786939
GO:0007399 nervous system development TAS9786939
GO:0008283 cell proliferation TAS3211147
GO:0008543 fibroblast growth factor receptor signaling pathway TAS9786939
GO:0010001 glial cell differentiation IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FGF5
3 Novoseek chemical compound relationships for FGF5 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
thymidine 11.36 1 8394679 (1)
tyrosine 0.00 1 9786939 (1)
gold 0.00 1 9134330 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (FGF5)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_033143

              Sigma-Aldrich siRNA and siRNA Panels for FGF5  
                     Sigma-Aldrich shRNA for FGF5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_004464  NM_033143  

REFSEQ mRNAs for FGF5 gene (2 alternative transcripts): 

NM_004464.3   NM_033143.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_004464  NM_033143  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004464
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004464
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_004464 

Additional cDNA sequence: 

AB016517.1 AF171928.1 AF355187.1 AF535149.1 AK090557.1 AK291962.1 AK312065.1 BC074858.2 
BC074859.2 BC131502.1 M37825.1 

4 DOTS entries:

DT.95153354  DT.209995  DT.99932759  DT.102822933 

24/26 AceView cDNA sequences (see all 26 ):

BC074859 AL702742 N33833 AI082077 BQ773933 CA487169 BC074858 AA373315 
AK090557 M37825 AF171928 N24958 NM_004464 NM_033143 BQ001160 AF355187 
BG169736 AF535149 AA373667 AA373379 AB016517 AA461028 BQ018239 AW168314 

highest scoring ESTs for FGF5:

M37825 W46575 AA373315 AB016517 AF171928 AF535149 AI050722 AK090557 AW168314 BG169736 

Unigene Cluster for FGF5:

Fibroblast growth factor 5
Hs.37055  [show with all ESTs]
Unigene Representative Sequence: NM_004464


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000357642  ENST00000380628  ENST00000312465  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FGF5 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for FGF5

1 / 2 / 3

8 probe-sets matching FGF5 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

46070_r_at2, 3 U95-B 1 1.00 1.00 0.82 1.20 W46575 0.80 1.00 0.91 1

1732_at2, 3 U95-A 1 1.00 1.00 0.75 0.95 M37825 1.00 0.90 0.95 1

210310_s_at2, 3 U133-A 1 1.00 1.00 -- -- AB016517 0.80 0.88 0.84 1

210311_at2, 3 U133-A 1 1.00 1.00 -- -- AF171928 0.80 0.88 0.84 1

208378_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004464 0.60 0.83 0.73 1

210310_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

210311_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

208378_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.37055

Expression variation in blood from EXPOLDB for FGF5

UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
Tissue specificity: Expressed in neonatal brain

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for FGF5 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
FGF51   -- fibroblast growth factor 5 87.19(n)
86.57(a)
608459  XM_845490.1  XP_850583.1 
chimpanzee
(Pan troglodytes)
FGF51   -- fibroblast growth factor 5 99.5(n)
99.25(a)
471190  XM_526572.2  XP_526572.2 
cow
(Bos taurus)
FGF51   -- fibroblast growth factor 5 91.29(n)
91.04(a)
536771  XM_001250317.1  XP_001250318.1 
rat
(Rattus norvegicus)
Fgf51   -- fibroblast growth factor 5 86.54(n)
86.04(a)
60662  NM_022211.1  NP_071547.1 
mouse
(Mus musculus)
Fgf51, 5 5 (55.00 cM)5
fibroblast growth factor 51, 5 86.19(n)1
87.45(a)1
141761  NM_010203.31  NP_034333.11 
 AB0165165  AK0286945  (see all 11)
About this table        Species with no ortholog for FGF5

ENSEMBL Gene Tree for FGF5
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for FGF5 gene
FGF162  FGF202  FGF92  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/301 NCBI SNPs in FGF5 are shown (see all 301 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 243)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 4 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs68382031,2
A,C,F,H81428016(+) AACCAA/TTCCAG 2 -- ut31 ese317Minor allele frequency- N:0.00EA NA EU WA NS 1194
rs37333361,2
A,C,F,H81426987(+) TTTCAA/GTGTGA 2 -- ut3110Minor allele frequency- G:0.25EA EU WA NS 2104
rs46901501,2
A,C,F,H81430594(+) ACAAAC/GAGTTA 2 -- ut3112Minor allele frequency- G:0.44EU EA WA NA NS 728
rs100067531,2
A,C,F,H81428866(+) AACAGG/AAACTA 2 -- ut31 ese312Minor allele frequency- A:0.14NA EU EA WA NS 748
rs174662891,2
C,F,H81405057(+) CATTCA/GGCAGC 2 -- ng5112Minor allele frequency- G:0.03NA EU EA WA NS 750
rs10472451,2
A,C,F81406919(+) GGCAGA/CGCCAG 2 -- ut516Minor allele frequency- C:0.09MN NS 374
rs68492321,2
C,F,H81428455(+) TACCAT/GATAAG 2 -- ut3112Minor allele frequency- G:0.10NA EU EA WA NS 726
rs38067521,2
A,C,F81405504(+) TATGCT/GTTTCA 2 -- ng519Minor allele frequency- G:0.20EA NA NS 1640
rs170048571,2
C,F,H81404998(+) TCTTCG/ATCACT 2 -- ng5116Minor allele frequency- A:0.05NA EU EA WA NS 1170
rs170048581,2
C,F,H81405611(+) TAGCAC/AGGGCC 2 -- ng5112Minor allele frequency- A:0.05NA EU EA WA NS 736
About this table

HapMap Linkage Disequilibrium images for FGF5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 165190

9 Novoseek disease relationships for FGF5 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
kaposi sarcoma 40.51 3 1987771 (3)
carcinoma renal cell 27.65 4 11454700 (1), 8616814 (1), 14724640 (1)
pancreatic cancer 22.70 6 9333017 (4), 11876253 (1)
gastric cancer 13.52 1 7511892 (1)
tumors 4.18 7 2005884 (1), 8374885 (1), 1716514 (1), 1992446 (1) (see all 5)
melanoma 0.00 1 1716514 (1)
cancer 0.00 4 11454700 (1), 9333017 (1), 14724640 (1)
myocardial ischemia 0.00 3 8616711 (1), 16149904 (1)
adenocarcinoma 0.00 2 11454700 (2)
About this table

Human Genome Epidemiology Navigator: FGF5 (1 document)
Tumor Gene Database: FGF5

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/85 PubMed articles for FGF5 gene (see all 85 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2250 HGNC: 3683 AceView: FGF5 Ensembl:ENSG00000138675 euGenes: HUgn2250
ECgene: FGF5 H-InvDB: FGF5
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for FGF5 Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf5/
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for FGF5:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FGF5-related products

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 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
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 Predesigned and custom siRNAs for FGF5 Antibodies for FGF5
 Explore super-pooled esiRNAs Proteins for FGF5
 Lentivirus-delivered shRNAs for FGF5 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

 Recombinant Proteins (FGF5)
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 Recombinant Proteins
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 Search OriGene for FGF5
 Search Tocris compounds for FGF5




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for FGF5

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