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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF5 Gene

protein-coding   GIFtS: 59
GCID: GC04P081187

fibroblast growth factor 5
 Explore 22 diseases affiliated with
FGF5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FGF5    

Aliases
for FGF5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fibroblast Growth Factor 51 2
Heparin-Binding Growth Factor 52 3
HBGF-52 3
Smag-822 3
FGF-53

External Ids:    HGNC: 36831   Entrez Gene: 22502   Ensembl: ENSG000001386757   OMIM: 1651905   UniProtKB: P120343   

Export aliases for FGF5 gene to outside databases

Previous GC identifers: GC04P081074 GC04P081473 GC04P081580 GC04P081646 GC04P081545 GC04P081406 GC04P076931


Summaries
for FGF5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FGF5:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess
broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including
embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified
as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the
homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an
inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been
identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
Function: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal
regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from
anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity)

Gene Wiki entry for FGF5


Genomic Views
for FGF5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF5 gene promoter:
         AREB6   MEF-2   MyoD   CUTL1   Nkx2-5   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21

FGF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P081187:  view genomic region     (about GC identifiers)

Start:
 81,187,742 bp from pter      End:
 81,257,834 bp from pter
Size:
 70,093 bases      Orientation:
 plus strand

Proteins
for FGF5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034 (See protein sequence)
Recommended Name: Fibroblast growth factor 5 precursor  
Size: 268 amino acids; 29551 Da
Subunit: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is
increased by heparan sulfate glycosaminoglycans that function as coreceptors
Subcellular location: Secreted (Potential)
Developmental stage: Can transform NIH 3T3 cells
Sequence caution: Sequence=AAB60698.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R554 O75846 Q3Y8M3
Alternative splicing: 2 isoforms:  P12034-1   P12034-2   (Seems to have an antagonistic effect compared to that of the isoform Long)

Explore the universe of human proteins at neXtProt for FGF5: NX_P12034

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P12034

    • FGF5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004455.2  NP_149134.1  

    ENSEMBL proteins: 
     ENSP00000311697   ENSP00000398353   ENSP00000423903  
    Reactome Protein details: P12034
    Human Recombinant Protein Products: 
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    Novus Biologicals FGF5 Proteins
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    Browse Sino Biological Recombinant Proteins
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    Uscn Proteins for FGF5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9786939


    FGF5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FGF5

    Protein Domains /
    Families
    for FGF5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FGF5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry P12034

    ProtoNet protein and cluster: P12034

    2 Blocks protein families:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
    Similarity: Belongs to the heparin-binding growth factors family


    Function
    for FGF5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
    Function: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal
    regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from
    anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity)

         Genatlas biochemistry entry for FGF5:
    fibroblast growth factor 5,basic,HST oncogene homolog,expressed by fibroblasts,epithelium and during embryonic
    development mitogenic for fibroblast

    miRNA
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    hsa-miR-548j hsa-miR-3678-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-376b hsa-miR-106a hsa-miR-374a hsa-miR-138-2*
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IDA8386828
    GO:0008083growth factor activity IEA--


    FGF5 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Fgf5tm1Mrt for FGF5
         1 MGI mutant phenotype (inferred from 5 alleles) (MGI details for Fgf5):
     integument 

    FGF5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FGF5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1FGFR2c binds to FGF
    8/16 pathways (see all 16)
    		FGFR2c binds to FGF1.00
    		Activated point mutants of FGFR20.76
    		FGFR2c ligand binding and activation1.00
    		FGFR1c ligand binding and activation0.71
    		FGFR3c ligand binding and activation0.79
    		Signaling by activated point mutants of FGFR10.71
    		FGFR3 ligand binding and activation0.79
    		FGFR1 ligand binding and activation0.59
    2Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    3Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    4PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    5IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF5 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for FGF5 
        Regulation of Actin Cytoskeleton

    5/56        Reactome Pathways for FGF5 (see all 56)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    4         Kegg Pathways  (Kegg details for FGF5):
        MAPK signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Melanoma


    FGF5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for FGF5 (P120343 ENSP000003116974) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR3P226073, ENSP000002607954I2D: score=1 STRING: ENSP00000260795
    FGFR4P224553, ENSP000002924084I2D: score=1 STRING: ENSP00000292408
    EGFRENSP000002754934STRING: ENSP00000275493
    IGF1RENSP000002680354STRING: ENSP00000268035
    METENSP000003172724STRING: ENSP00000317272
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS9786939
    GO:0007399nervous system development TAS9786939
    GO:0008283cell proliferation TAS3211147
    GO:0008284positive regulation of cell proliferation IGI8663044
    GO:0008286insulin receptor signaling pathway TAS--


    FGF5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FGF5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF5

    1 HMDB Compound for FGF5    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--
    5 Novoseek chemical compound relationships for FGF5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidine 10.3 1 8394679 (1)
    vegf 9.36 3 17161616 (1), 19450457 (1)
    heparin 4.52 4 8386828 (1), 11876253 (1), 7547864 (1)
    tyrosine 0 1 9786939 (1)
    gold 0 1 9134330 (1)

    Search CenterWatch for drugs/clinical trials and news about FGF5 

    Transcripts
    for FGF5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FGF5 gene (2 alternative transcripts): 
    NM_004464.3  NM_033143.2  

    Unigene Cluster for FGF5:

    Fibroblast growth factor 5
    Hs.37055  [show with all ESTs]
    Unigene Representative Sequence: NM_004464
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312465 ENST00000456523(uc003hmd.3 uc003hme.3) ENST00000380628
    ENST00000507780 ENST00000503413

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    hsa-miR-548j hsa-miR-3678-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-376b hsa-miR-106a hsa-miR-374a hsa-miR-138-2*
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    Additional cDNA sequence: 

    AB016517.1 AF171928.1 AF355187.1 AF535149.1 AK090557.1 AK291962.1 AK312065.1 BC074858.2 
    BC074859.2 BC131502.1 M37825.1 

    4 DOTS entries:

    DT.95153354  DT.209995  DT.99932759  DT.102822933 

    24/26 AceView cDNA sequences (see all 26):

    AA373315 BC074859 AK090557 AI082077 AL702742 BQ773933 BC074858 N33833 
    CA487169 NM_004464 AF355187 AA373379 BG169736 N24958 AB016517 AF171928 
    AA373667 AF535149 M37825 BQ001160 NM_033143 AA461028 BQ018239 AW168314 

    GeneLoc Exon Structure


    Expression
    for FGF5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FGF5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EpiblastEpiblastEarly Epiblast CellsEarly Embryo
    EpiblastEpiblastEpiblast CellsEarly Embryo
    HypoblastExtraembryonic EndodermExtraembryonic Endoderm CellsExtraembryonic Tissues, Yolk Sac
    HypoblastVisceral EndodermEarly Distal Visceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    HypoblastVisceral EndodermVisceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    Primitive StreakPrimitive StreakPrimitive Streak CellsEarly Embryo
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    LiverHepatic MesenchymeMesothelial CellsLiver
    BoneMandibular ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Epiblast Stem Cells (Fetal Stem / Progenitor Cell)Early Embryo
    Epiblast-like cells (Reconstitution of mo...)
    Anterior neural specified EBs (Differentiation of h...)
    Endoderm progenitor-like cells (Generation and expan...)

    See FGF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF5

    SOURCE GeneReport for Unigene cluster: Hs.37055

    UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
    Tissue specificity: Expressed in neonatal brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF5: 
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              Growth Factors in human mouse rat
              Cell Lineage Identification in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for FGF5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FGF5 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FGF51 fibroblast growth factor 5 64.36(n)
    68.83(a)    		   770457  XM_001233790.2  XP_001233791.2 
    lizard
    (Anolis carolinensis)    		 Reptilia FGF56
    		 --
    		 71(a)
    		 1 ↔ 1
    		 GL343425.1(423959-453821)
    zebrafish
    (Danio rerio)    		 Actinopterygii fgf51 fibroblast growth factor 5 66.49(n)
    71.35(a)    		   494454  NM_001009561.1  NP_001009561.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea let-7566
    		 Protein let-756
    		 14(a)
    		 1 → many
    		 III(6407076-6409965)


    ENSEMBL Gene Tree for FGF5 (if available)
    TreeFam Gene Tree for FGF5 (if available) 

    Paralogs
    for FGF5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF5 gene
    FGF122  FGF202  FGF162  FGF42  FGF92  FGF62  FGF32  FGF72  
    FGF112  FGF102  FGF222  FGF132  FGF142  
    15 SIMAP similar genes for FGF5 using alignment to 3 protein entries:     FGF5_HUMAN (see all proteins):
    FGF20    KGFLP1    PRED3    FGF7    FGF22    FGF16
    FGF10    FGF9    FGF11    FGF14    FGF3    FGF6
    FGF1    FGF2    FGF4

    FGF5 for paralogs           About GeneDecksing



    Genomic Variants
    for FGF5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF5
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF5

    Disorders / Diseases
    for FGF5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FGF5 for disorders           About GeneDecksing

    OMIM gene information: 165190    OMIM disorders: --

    20/22 diseases for FGF5 (see all 22):    About MalaCards
    kaposi's sarcoma    acquired immunodeficiency syndrome    renal cell carcinoma    rheumatoid arthritis
    sarcoma    pancreatic cancer    ischemia    choroiditis
    seizures    pancreatitis    arthritis    periodontitis
    ovarian cancer    immunodeficiency    melanoma    adenocarcinoma
    breast cancer    glioblastoma    hypertension    carcinoma

    9 Novoseek disease relationships for FGF5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kaposi sarcoma 45.6 3 1987771 (3)
    carcinoma renal cell 25.8 4 11454700 (1), 8616814 (1), 14724640 (1)
    gastric cancer 20.7 1 7511892 (1)
    pancreatic cancer 20.4 6 9333017 (4), 11876253 (1)
    tumors 5.04 7 2005884 (1), 8374885 (1), 1716514 (1), 1992446 (1) (see all 5)
    myocardial ischemia 0 3 8616711 (1), 16149904 (1)
    adenocarcinoma 0 3 11454700 (2), 8334620 (1)
    melanoma 0 1 1716514 (1)
    cancer 0 4 11454700 (1), 9333017 (1), 14724640 (1)

    Human Genome Epidemiology (HuGE) Navigator: FGF5 (9 documents)
    Tumor Gene Database (TGDB): FGF5

    Export disorders for FGF5 gene to outside databases

    Publications
    for FGF5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF5 gene, integrated from 9 sources (see all 100):
    (articles sorted by number of sources associating them with FGF5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. (PubMed id 3211147)1, 2, 3 Zhan X.... Goldfarb M. (1988)
    2. Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. (PubMed id 1700424)1, 2, 9 Haub O.... Goldfarb M. (1990)
    3. Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes. (PubMed id 10823842)1, 2, 9 de Vries C.J.M.... Pannekoek H. (2000)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)1, 2 Ornitz D.M....Goldfarb M. (1996)
    6. The FGF-related oncogenes hst and int.2, and the bcl.1 locus are contained within one megabase in band q13 of chromosome 11, while the fgf.5 oncogene maps to 4q21. (PubMed id 2577873)1, 3 Nguyen C....Jordan B.R. (1988)
    7. Expression of the IIIc variant of FGF receptor-1 confers mitogenic responsiveness to heparin and FGF-5 in TAKA-1 pancreatic ductal cells. (PubMed id 11876253)1, 9 Kornmann M....Korc M. (2001)
    8. An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity. (PubMed id 9786939)1, 9 Ozawa K....Imamura T. (1998)
    9. Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions. (PubMed id 9333017)1, 9 Kornmann M....Korc M. (1997)
    10. Biosynthesis of human fibroblast growth factor-5. (PubMed id 2005884)1, 9 Bates B.... Goldfarb M. (1991)

    External Searches for FGF5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FGF5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2250 HGNC: 3683 AceView: FGF5 Ensembl:ENSG00000138675 euGenes: HUgn2250
    ECgene: FGF5 Kegg: 2250 H-InvDB: FGF5

    Other Databases showing FGF5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FGF5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf5/

    Intellectual Property
    for FGF5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FGF5 gene:
    Search GeneIP for patents involving FGF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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