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Aliases & Descriptions for FGF5
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FGF-5 3 HBGF-5 2 , 3 Smag-82 2 , 3
Descriptions Heparin-binding growth factor 5 2 , 3 fibroblast growth factor 5 2
Search outside databases for aliases for FGF5 genePrevious GC identifers: GC04P081074 GC04P081473 GC04P081580 GC04P081646 GC04P081545
Summaries for FGF5 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for FGF5 : The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGFfamily members possess broad mitogenic and cell survival activities, and are involved in a varietyof biological processes, including embryonic development, cell growth, morphogenesis, tissuerepair, tumor growth and invasion. This gene was identified as an oncogene, which conferstransforming potential when transfected into mammalian cells. Targeted disruption of the homologof this gene in mouse resulted in the phenotype of abnormally long hair, which suggested afunction as an inhibitor of hair elongation. Alternatively spliced transcript variants encodingdifferent isoforms have been identified. [provided by RefSeq] UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034 Function : Functions as an inhibitor of hair elongation by promoting progression from anagen, thegrowth phase of the hair follicle, into catagen the apoptosis-induced regression phase (Bysimilarity)
Gene Wiki entry for FGF5
Genomic Location for FGF5
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the FGF5 gene Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q21.21 HGNC cytogenetic band: 4q21 FGF5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P081406:
(about GC identifiers )
Start:
81,406,766 bp from pter
End:
81,431,195 bp from pter
Size:
24,430 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000004.10 NT_016354.18 Proteins for FGF5
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034 (See
protein sequence )Recommended Name: Fibroblast growth factor 5 precursor Size : 268 amino acids; 29551 Da
Subcellular location : Secreted (Potential)
Developmental stage : Can transform NIH 3T3 cells
Secondary accessions : O75846 Q3Y8M3Alternative splicing : 2 isoforms : P12034-1 P12034-2
REFSEQ proteins (2 alternative transcripts):
NP_004455.2 NP_149134.1 ENSEMBL proteins: ENSP00000350269 ENSP00000370002 ENSP00000311697 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for FGF5: Assays for FGF5:
Protein
Domains/ Families for FGF5(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P12034 ProtoNet protein and cluster: P12034
2 Blocks protein families : IPB002209 Heparin binding growth factor family signature IPB002348 IL1/HBGF family signature UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034 Similarity : Belongs to the heparin-binding growth factors family
Gene Function for FGF5
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
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Millipore ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_033143 Applied Biosystems Silencer ® siRNAs for FGF5 Sigma-Aldrich siRNA and siRNA Panels for FGF5 Sigma-Aldrich shRNA for FGF5 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004464                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004464                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_004464  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004464 UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034 Function : Functions as an inhibitor of hair elongation by promoting progression from anagen, thegrowth phase of the hair follicle, into catagen the apoptosis-induced regression phase (Bysimilarity)
Genatlas biochemistry entry for FGF5 :fibroblast growth factor 5,basic,HST oncogene homolog,expressed by fibroblasts,epithelium andduring embryonic development mitogenic for fibroblast
2 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Fgf5) :1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008083 growth factor activity
IEA --
About this table
Pathways & Interactions for FGF5
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for FGF5 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for FGF5 5/34 Interacting proteins for FGF5 (ENSP00000311697 3 ) via UniProtKB, MINT, and/or STRING (see all 34
)About this table 5 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for FGF5 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for FGF5 3 Novoseek chemical compound relationships for FGF5 gene
About this table
Transcripts for FGF5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_033143 Sigma-Aldrich siRNA and siRNA Panels for FGF5 Sigma-Aldrich shRNA for FGF5 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004464 NM_033143
REFSEQ mRNAs for FGF5 gene (2 alternative transcripts): NM_004464.3 NM_033143.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004464 NM_033143
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004464                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004464                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_004464  
Additional cDNA sequence: AB016517.1 AF171928.1 AF355187.1 AF535149.1 AK090557.1 AK291962.1 AK312065.1 BC074858.2 BC074859.2 BC131502.1 M37825.1
4 DOTS entries : DT.95153354 DT.209995 DT.99932759 DT.102822933
24/26 AceView cDNA sequences (see all 26
):BC074859 AL702742 N33833 AI082077 BQ773933 CA487169 BC074858 AA373315 AK090557 M37825 AF171928 N24958 NM_004464 NM_033143 BQ001160 AF355187 BG169736 AF535149 AA373667 AA373379 AB016517 AA461028 BQ018239 AW168314
highest scoring ESTs for FGF5 :M37825 W46575 AA373315 AB016517 AF171928 AF535149 AI050722 AK090557 AW168314 BG169736
Unigene Cluster for FGF5: Fibroblast growth factor 5 Hs.37055 [show with all ESTs ] Unigene Representative Sequence: NM_004464 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000357642
ENST00000380628
ENST00000312465
Expression for FGF5
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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FGF5 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for FGF5 1 / 2 / 3
8 probe-sets matching FGF5 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.37055 Expression variation in blood from EXPOLDB for FGF5
UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034 Tissue specificity : Expressed in neonatal brain
Orthologs for FGF5
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for FGF5 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for FGF5 ENSEMBL Gene Tree for FGF5 Paralogs for FGF5 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for FGF5 gene FGF16 2 FGF20 2 FGF9 2
SNPs/Variants for FGF5 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for FGF5 (up to first 250kb)
Disorders & Mutations for FGF5
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 165190 9 Novoseek disease relationships for FGF5 gene
About this table Human Genome Epidemiology Navigator: FGF5 (1 document)Tumor Gene Database : FGF5
Medical News for FGF5 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for FGF5 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/85 PubMed articles for FGF5 gene (see all 85
): The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. (PubMed id 3211147) 2, 3, 4 Zhan X.... Goldfarb M. (1988) Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. (PubMed id 1700424) 1, 3, 4 Haub O.... Goldfarb M. (1990) Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes. (PubMed id 10823842) 1, 3, 4 de Vries C.J.M.... Pannekoek H. (2000) The FGF-related oncogenes hst and int.2, and the bcl.1 locus are contained within one megabase in band q13 of chromosome 11, while the fgf.5 oncogene maps to 4q21. (PubMed id 2577873) 2, 3 Nguyen C....Jordan B.R. (1988) Expression of the IIIc variant of FGF receptor-1 confers mitogenic responsiveness to heparin and FGF-5 in TAKA-1 pancreatic ductal cells. (PubMed id 11876253) 1, 3 Kornmann M....Korc M. (2001) An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity. (PubMed id 9786939) 1, 3 Ozawa K....Imamura T. (1998) Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions. (PubMed id 9333017) 1, 3 Kornmann M....Korc M. (1997) Biosynthesis of human fibroblast growth factor-5. (PubMed id 2005884) 1, 3 Bates B.... Goldfarb M. (1991) FGF5 as an oncogenic factor in human glioblastoma multiforme: autocrine and paracrine activities. (PubMed id 18362893) 1, 3 Allerstorfer S....Berger W. (2008) Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas. (PubMed id 11454700) 1, 3 Hanada K....Yang J.C. (2001)
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Genome Databases showing FGF5
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing FGF5
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Specialized Databases showing FGF5 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for FGF5 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for FGF5:
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