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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF5 Gene

protein-coding   GIFtS: 60
GCID: GC04P081187

Fibroblast Growth Factor 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibroblast Growth Factor 51 2
Heparin-Binding Growth Factor 52 3
HBGF-52 3
Smag-822 3
FGF-53

External Ids:    HGNC: 36831   Entrez Gene: 22502   Ensembl: ENSG000001386757   OMIM: 1651905   UniProtKB: P120343   

Export aliases for FGF5 gene to outside databases

Previous GC identifers: GC04P081074 GC04P081473 GC04P081580 GC04P081646 GC04P081545 GC04P081406 GC04P076931


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF5 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene
was identified as an oncogene, which confers transforming potential when transfected into mammalian cells.
Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which
suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding
different isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF5 Gene: 
FGF5 (fibroblast growth factor 5) is a protein-coding gene. Diseases associated with FGF5 include acquired immunodeficiency syndrome, and kaposi's sarcoma, and among its related super-pathways are Regulation of actin cytoskeleton and FGFR2c ligand binding and activation. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
Function: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for
normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression
from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By
similarity)

Gene Wiki entry for FGF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF5 gene promoter:
         AREB6   MEF-2   MyoD   CUTL1   Nkx2-5   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21

FGF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P081187:  view genomic region     (about GC identifiers)

Start:
81,187,742 bp from pter      End:
81,257,834 bp from pter
Size:
70,093 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034 (See protein sequence)
Recommended Name: Fibroblast growth factor 5 precursor  
Size: 268 amino acids; 29551 Da
Subunit: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is
increased by heparan sulfate glycosaminoglycans that function as coreceptors
Subcellular location: Secreted (Potential)
Developmental stage: Can transform NIH 3T3 cells
Sequence caution: Sequence=AAB60698.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R554 O75846 Q3Y8M3
Alternative splicing: 2 isoforms:  P12034-1   P12034-2   (Seems to have an antagonistic effect compared to that of the isoform Long)

Explore the universe of human proteins at neXtProt for FGF5: NX_P12034

Explore proteomics data for FGF5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12034

  • FGF5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FGF5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004455.2  NP_149134.1  

    ENSEMBL proteins: 
     ENSP00000311697   ENSP00000398353   ENSP00000423903  
    Reactome Protein details: P12034
    Human Recombinant Protein Products for FGF5: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for FGF5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9786939

    FGF5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry P12034

    ProtoNet protein and cluster: P12034

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
    Similarity: Belongs to the heparin-binding growth factors family


    FGF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF5_HUMAN, P12034
    Function: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for
    normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression
    from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By
    similarity)

         Genatlas biochemistry entry for FGF5:
    fibroblast growth factor 5,basic,HST oncogene homolog,expressed by fibroblasts,epithelium and during embryonic
    development mitogenic for fibroblast

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IDA8386828
    GO:0008083growth factor activity IEA--
         
    FGF5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 6 alleles(MGI details for Fgf5):
     integument 

    FGF5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fgf5tm1Mrt for FGF5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FGF5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FGF5

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FGF5 About   (see all 31)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2FGFR2c ligand binding and activation
    FGFR ligand binding and activation0.79
    Signaling by activated point mutants of FGFR10.79
    SHC-mediated cascade0.79
    FGFR1c ligand binding and activation0.79
    FGFR2c ligand binding and activation0.79
    FGFR2 ligand binding and activation0.76
    FGFR1 ligand binding and activation0.79
    Signaling by FGFR2 mutants0.76
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    5PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI-3K cascade0.88
    Signaling by SCF-KIT0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF5 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for FGF5
        Regulation of Actin Cytoskeleton


    5/57        Reactome Pathways for FGF5 (see all 57)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    5/6         Kegg Pathways  (Kegg details for FGF5) (see all 6):
        MAPK signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Proteoglycans in cancer


    FGF5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for FGF5 (P120343 ENSP000003116974) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR3P226073, ENSP000002607954I2D: score=1 STRING: ENSP00000260795
    FGFR4P224553, ENSP000002924084I2D: score=1 STRING: ENSP00000292408
    EGFRENSP000002754934STRING: ENSP00000275493
    IGF1RENSP000002680354STRING: ENSP00000268035
    METENSP000003172724STRING: ENSP00000317272
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007267cell-cell signaling TAS9786939
    GO:0007399nervous system development TAS9786939
    GO:0008283cell proliferation TAS3211147
    GO:0008284positive regulation of cell proliferation IGI8663044

    FGF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF5

    1 HMDB Compound for FGF5    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    5 Novoseek inferred chemical compound relationships for FGF5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidine 10.3 1 8394679 (1)
    vegf 9.36 3 17161616 (1), 19450457 (1)
    heparin 4.52 4 8386828 (1), 11876253 (1), 7547864 (1)
    tyrosine 0 1 9786939 (1)
    gold 0 1 9134330 (1)

    Search CenterWatch for drugs/clinical trials and news about FGF5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FGF5 gene (2 alternative transcripts): 
    NM_004464.3  NM_033143.2  

    Unigene Cluster for FGF5:

    Fibroblast growth factor 5
    Hs.37055  [show with all ESTs]
    Unigene Representative Sequence: NM_004464
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312465 ENST00000456523(uc003hmd.3 uc003hme.3) ENST00000380628
    ENST00000507780 ENST00000503413
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    Additional mRNA sequence: 

    AB016517.1 AF171928.1 AF355187.1 AF535149.1 AK090557.1 AK291962.1 AK312065.1 BC074858.2 
    BC074859.2 BC131502.1 M37825.1 

    4 DOTS entries:

    DT.95153354  DT.209995  DT.99932759  DT.102822933 

    24/26 AceView cDNA sequences (see all 26):

    AL702742 BQ773933 AA373315 AK090557 N33833 BC074858 AI082077 BC074859 
    CA487169 BG169736 N24958 M37825 BQ001160 AF535149 AF171928 AA373667 
    NM_004464 AF355187 AB016517 NM_033143 AA373379 BQ018239 AA461028 AW168314 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF5 expression in normal human tissues (normalized intensities)      FGF5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FGF5 Expression
    About this image


    FGF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 5 entries
             Early Epiblast Cells Epiblast
             Epiblast Stem Cells
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             heart/atrium   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
             brain/midbrain   
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 3 entries
             Visceral Endoderm Cells Visceral Endoderm
     
     Yolk Sac (Extraembryonic Tissues)    fully expand to see all 3 entries
             Visceral Endoderm Cells Visceral Endoderm

    See FGF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF5

    SOURCE GeneReport for Unigene cluster: Hs.37055

    UniProtKB/Swiss-Prot: FGF5_HUMAN, P12034
    Tissue specificity: Expressed in neonatal brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF5: 
              Notch Signaling Targets in human mouse rat
              Growth Factors in human mouse rat
              Cell Lineage Identification in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FGF5 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf51 , 5 fibroblast growth factor 51, 5 86.19(n)1
    87.45(a)1
      5 (47.77 cM)5
    141761  NM_010203.41  NP_034333.11 
     982541845 
    chicken
    (Gallus gallus)
    Aves FGF51 fibroblast growth factor 5 64.36(n)
    68.83(a)
      770457  XM_001233790.2  XP_001233791.2 
    lizard
    (Anolis carolinensis)
    Reptilia FGF56
    fibroblast growth factor 5
    69(a)
    1 ↔ 1
    GL343425.1(424005-456815)
    zebrafish
    (Danio rerio)
    Actinopterygii fgf51 fibroblast growth factor 5 66.49(n)
    71.35(a)
      494454  NM_001009561.1  NP_001009561.1 


    ENSEMBL Gene Tree for FGF5 (if available)
    TreeFam Gene Tree for FGF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF5 gene
    FGF122  FGF162  FGF202  FGF42  FGF62  FGF92  FGF32  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    15 SIMAP similar genes for FGF5 using alignment to 3 protein entries:     FGF5_HUMAN (see all proteins):
    FGF20    KGFLP1    PRED3    FGF7    FGF22    FGF16
    FGF10    FGF9    FGF11    FGF14    FGF3    FGF6
    FGF1    FGF2    FGF4

    FGF5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/640 SNPs in FGF5 are shown (see all 640)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1855424491,2
    --81004757(+) GGAACA/CACTCT 2 -- us2k10--------
    rs170048571,2
    C,F,H--81004837(+) TCTTCG/ATCACT 2 -- us2k127Minor allele frequency- A:0.06NA NS EA WA 2476
    rs287182381,2
    C,F--81004861(+) GTGTAT/CTTGCG 2 -- us2k17Minor allele frequency- C:0.04NS WA 310
    rs174662891,2
    C,F,H--81004896(+) CATTCA/GGCAGC 2 -- us2k120Minor allele frequency- G:0.05NA NS EA 1648
    rs1508250491,2
    --81004946(+) TCAGGG/TCATTG 2 -- us2k10--------
    rs38067511,2
    C,F--81005005(+) TCCCCA/GGAAGA 2 -- us2k10--------
    rs353208471,2
    C,F--81005031(+) AGTAGA/GCCATT 2 -- us2k16Minor allele frequency- G:0.02NS WA 308
    rs356143881,2
    F--81005105(+) CCCACC/TCTAGT 2 -- us2k15Minor allele frequency- T:0.01NS 190
    rs340503301,2
    C,F--81005118(+) AGGGAG/AAAGTA 2 -- us2k16Minor allele frequency- A:0.06NS NA 310
    rs1161766361,2
    F--81005146(+) ACAGTG/AGACAG 2 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for FGF5 (81187742 - 81257834 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FGF5: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF5
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165190    OMIM disorders: --

    20/22 diseases for FGF5 (see all 22):    About MalaCards
    acquired immunodeficiency syndrome    kaposi's sarcoma    esophageal adenocarcinoma    choroiditis
    pancreatic cancer    ischemia    sarcoma    periodontitis
    renal cell carcinoma    pancreatitis    melanoma    glioblastoma
    hypertension    retinitis    adenocarcinoma    rheumatoid arthritis
    endotheliitis    arthritis    gastric cancer    esophagitis


    FGF5 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for FGF5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kaposi sarcoma 45.6 3 1987771 (3)
    carcinoma renal cell 25.8 4 11454700 (1), 8616814 (1), 14724640 (1)
    gastric cancer 20.7 1 7511892 (1)
    pancreatic cancer 20.4 6 9333017 (4), 11876253 (1)
    tumors 5.04 7 2005884 (1), 8374885 (1), 1716514 (1), 1992446 (1) (see all 5)
    myocardial ischemia 0 3 8616711 (1), 16149904 (1)
    adenocarcinoma 0 3 11454700 (2), 8334620 (1)
    melanoma 0 1 1716514 (1)
    cancer 0 4 11454700 (1), 9333017 (1), 14724640 (1)

    Genetic Association Database (GAD): FGF5
    Human Genome Epidemiology (HuGE) Navigator: FGF5 (9 documents)
    Tumor Gene Database (TGDB): FGF5

    Export disorders for FGF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF5 gene, integrated from 9 sources (see all 102):
    (articles sorted by number of sources associating them with FGF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. (PubMed id 3211147)1, 2, 3 Zhan X.... Goldfarb M. (1988)
    2. Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. (PubMed id 1700424)1, 2, 9 Haub O.... Goldfarb M. (1990)
    3. Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes. (PubMed id 10823842)1, 2, 9 de Vries C.J.M.... Pannekoek H. (2000)
    4. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    5. Confirmation of top polymorphisms in hypertension gen ome wide association study among Han Chinese. (PubMed id 20542020)1, 4 Niu W....Zhu D. (2010)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    7. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    8. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PubMed id 20479155)1, 4 Takeuchi F....Kato N. (2010)
    9. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (2009)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2250 HGNC: 3683 AceView: FGF5 Ensembl:ENSG00000138675 euGenes: HUgn2250
    ECgene: FGF5 Kegg: 2250 H-InvDB: FGF5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FGF5 gene:
    Search GeneIP for patents involving FGF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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