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Aliases for FGF5 Gene

Aliases for FGF5 Gene

  • Fibroblast Growth Factor 5 2 3
  • Heparin-Binding Growth Factor 5 3 4
  • Smag-82 3 4
  • HBGF-5 3 4
  • TCMGLY 3
  • FGF-5 4

External Ids for FGF5 Gene

Previous GeneCards Identifiers for FGF5 Gene

  • GC04P081074
  • GC04P081473
  • GC04P081580
  • GC04P081646
  • GC04P081545
  • GC04P081406
  • GC04P081187
  • GC04P076931

Summaries for FGF5 Gene

Entrez Gene Summary for FGF5 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF5 Gene

FGF5 (Fibroblast Growth Factor 5) is a Protein Coding gene. Diseases associated with FGF5 include trichomegaly and trichomegaly, cataract, and hereditary spherocytosis. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF5 Gene

  • Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).

Gene Wiki entry for FGF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF5 Gene

Genomics for FGF5 Gene

Regulatory Elements for FGF5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FGF5 Gene

Start:
80,266,588 bp from pter
End:
80,336,680 bp from pter
Size:
70,093 bases
Orientation:
Plus strand

Genomic View for FGF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF5 Gene

Proteins for FGF5 Gene

  • Protein details for FGF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12034-FGF5_HUMAN
    Recommended name:
    Fibroblast growth factor 5
    Protein Accession:
    P12034
    Secondary Accessions:
    • B2R554
    • O75846
    • Q3Y8M3
    • Q8NF90

    Protein attributes for FGF5 Gene

    Size:
    268 amino acids
    Molecular mass:
    29551 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
    SequenceCaution:
    • Sequence=AAB60698.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FGF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF5 Gene

Proteomics data for FGF5 Gene at MOPED

Post-translational modifications for FGF5 Gene

  • Glycosylation at Asn110
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGF5 Gene

Domains for FGF5 Gene

Gene Families for FGF5 Gene

HGNC:

Suggested Antigen Peptide Sequences for FGF5 Gene

Graphical View of Domain Structure for InterPro Entry

P12034

UniProtKB/Swiss-Prot:

FGF5_HUMAN :
  • P12034
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF5: view

Function for FGF5 Gene

Molecular function for FGF5 Gene

GENATLAS Biochemistry: fibroblast growth factor 5,basic,HST oncogene homolog,expressed by fibroblasts,epithelium and during embryonic development mitogenic for fibroblast
UniProtKB/Swiss-Prot Function: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).

Gene Ontology (GO) - Molecular Function for FGF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IDA 8386828
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with FGF5: view

Phenotypes for FGF5 Gene

MGI mutant phenotypes for FGF5:
inferred from 6 alleles
genes like me logo Genes that share phenotypes with FGF5: view

Animal Models for FGF5 Gene

MGI Knock Outs for FGF5:

Animal Model Products

CRISPR Products

miRNA for FGF5 Gene

miRTarBase miRNAs that target FGF5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FGF5 Gene

Localization for FGF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF5 Gene COMPARTMENTS Subcellular localization image for FGF5 gene
Compartment Confidence
extracellular 4
cytoskeleton 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FGF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 9786939
genes like me logo Genes that share ontologies with FGF5: view

Pathways for FGF5 Gene

SuperPathways for FGF5 Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 PI-3K cascade
3 Signaling by FGFR
4 FGFR ligand binding and activation
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FGF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007267 cell-cell signaling TAS 9786939
GO:0007399 nervous system development TAS 9786939
GO:0008283 cell proliferation TAS 3211147
GO:0008284 positive regulation of cell proliferation IGI 8663044
genes like me logo Genes that share ontologies with FGF5: view

Compounds for FGF5 Gene

(1) HMDB Compounds for FGF5 Gene

Compound Synonyms Cas Number PubMed IDs
Heparin
  • Arteven
9005-49-6

(5) Novoseek inferred chemical compound relationships for FGF5 Gene

Compound -log(P) Hits PubMed IDs
thymidine 10.3 1
vegf 9.36 2
heparin 4.52 3
tyrosine 0 1
gold 0 1
genes like me logo Genes that share compounds with FGF5: view

Transcripts for FGF5 Gene

Unigene Clusters for FGF5 Gene

Fibroblast growth factor 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF5 Gene

No ASD Table

Relevant External Links for FGF5 Gene

GeneLoc Exon Structure for
FGF5
ECgene alternative splicing isoforms for
FGF5

Expression for FGF5 Gene

mRNA expression in normal human tissues for FGF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF5 Gene

This gene is overexpressed in Brain - Cerebellum (6.1) and Brain - Cerebellar Hemisphere (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FGF5 Gene

SOURCE GeneReport for Unigene cluster for FGF5 Gene Hs.37055

mRNA Expression by UniProt/SwissProt for FGF5 Gene

P12034-FGF5_HUMAN
Tissue specificity: Expressed in neonatal brain
genes like me logo Genes that share expressions with FGF5: view

In Situ Assay Products

Orthologs for FGF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF5 35
  • 99.5 (n)
  • 99.25 (a)
FGF5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGF5 35
  • 89.38 (n)
  • 88.45 (a)
FGF5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF5 35
  • 86.45 (n)
  • 85.26 (a)
FGF5 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf5 35
  • 84.08 (n)
  • 87.04 (a)
Fgf5 16
Fgf5 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGF5 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF5 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf5 35
  • 85.41 (n)
  • 86.35 (a)
chicken
(Gallus gallus)
Aves FGF5 35
  • 65.45 (n)
  • 71.2 (a)
FGF5 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF5 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf5 35
  • 73.47 (n)
  • 77.04 (a)
zebrafish
(Danio rerio)
Actinopterygii fgf5 35
  • 66.31 (n)
  • 70.27 (a)
fgf5 36
  • 63 (a)
OneToOne
Species with no ortholog for FGF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF5 Gene

ENSEMBL:
Gene Tree for FGF5 (if available)
TreeFam:
Gene Tree for FGF5 (if available)

Paralogs for FGF5 Gene

Paralogs for FGF5 Gene

Selected SIMAP similar genes for FGF5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGF5: view

Variants for FGF5 Gene

Sequence variations from dbSNP and Humsavar for FGF5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs716678 -- 80,268,981(-) GTCAA(A/G)AGACC intron-variant
rs982804 -- 80,285,885(+) TGACC(C/T)CATTT intron-variant
rs1047245 -- 80,266,741(+) GGCAG(A/C)GCCAG upstream-variant-2KB, utr-variant-5-prime
rs1047247 -- 80,266,949(+) CCCTA(G/T)AGGCT upstream-variant-2KB, reference, missense
rs1379704 -- 80,278,193(+) TGTGC(A/G)TGAAA intron-variant

Relevant External Links for FGF5 Gene

HapMap Linkage Disequilibrium report
FGF5
Human Gene Mutation Database (HGMD)
FGF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FGF5 Gene

Disorders for FGF5 Gene

UniProtKB/Swiss-Prot

FGF5_HUMAN
  • Trichomegaly (TCMGLY) [MIM:190330]: A morphologic trait characterized by unusually long eyelashes and mild hypertrichosis of eyebrows. It can be observed in association with corneal irritation, cataracts, and hereditary spherocytosis. {ECO:0000269 PubMed:24989505}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(9) Novoseek inferred disease relationships for FGF5 Gene

Disease -log(P) Hits PubMed IDs
kaposi sarcoma 45.6 3
carcinoma renal cell 25.8 3
gastric cancer 20.7 1
pancreatic cancer 20.4 5
tumors 5.04 5

Relevant External Links for FGF5

Genetic Association Database (GAD)
FGF5
Human Genome Epidemiology (HuGE) Navigator
FGF5
Tumor Gene Database (TGDB):
FGF5
genes like me logo Genes that share disorders with FGF5: view

Publications for FGF5 Gene

  1. Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. (PMID: 1700424) Haub O. … Goldfarb M. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 23
  2. Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes. (PMID: 10823842) de Vries C.J.M. … Pannekoek H. (J. Biol. Chem. 2000) 3 4 23
  3. Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas. (PMID: 11454700) Hanada K.-I. … Yang J.C. (Cancer Res. 2001) 3 4 23
  4. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. (PMID: 3211147) Zhan X. … Goldfarb M. (Mol. Cell. Biol. 1988) 2 3 4
  5. Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors. (PMID: 1658709) Werner S. … Hofschneider P.H. (Oncogene 1991) 3 23

Products for FGF5 Gene

Sources for FGF5 Gene

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