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Aliases for FGF5 Gene

Aliases for FGF5 Gene

  • Fibroblast Growth Factor 5 2 3 5
  • Heparin-Binding Growth Factor 5 3 4
  • Smag-82 3 4
  • HBGF-5 3 4
  • TCMGLY 3
  • FGF-5 4

External Ids for FGF5 Gene

Previous GeneCards Identifiers for FGF5 Gene

  • GC04P081074
  • GC04P081473
  • GC04P081580
  • GC04P081646
  • GC04P081545
  • GC04P081406
  • GC04P081187
  • GC04P076931

Summaries for FGF5 Gene

Entrez Gene Summary for FGF5 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF5 Gene

FGF5 (Fibroblast Growth Factor 5) is a Protein Coding gene. Diseases associated with FGF5 include Trichomegaly and Kaposi Sarcoma. Among its related pathways are PI-3K cascade-FGFR3 and p70S6K Signaling. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF3.

UniProtKB/Swiss-Prot for FGF5 Gene

  • Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).

Gene Wiki entry for FGF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF5 Gene

Genomics for FGF5 Gene

Regulatory Elements for FGF5 Gene

Enhancers for FGF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FGF5 on UCSC Golden Path with GeneCards custom track

Promoters for FGF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FGF5 Gene

Chromosome:
4
Start:
80,266,588 bp from pter
End:
80,336,680 bp from pter
Size:
70,093 bases
Orientation:
Plus strand

Genomic View for FGF5 Gene

Genes around FGF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF5 Gene

Proteins for FGF5 Gene

  • Protein details for FGF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12034-FGF5_HUMAN
    Recommended name:
    Fibroblast growth factor 5
    Protein Accession:
    P12034
    Secondary Accessions:
    • B2R554
    • O75846
    • Q3Y8M3
    • Q8NF90

    Protein attributes for FGF5 Gene

    Size:
    268 amino acids
    Molecular mass:
    29551 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
    SequenceCaution:
    • Sequence=AAB60698.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FGF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF5 Gene

Post-translational modifications for FGF5 Gene

  • Glycosylation at Asn 110
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF5 Gene

No data available for DME Specific Peptides for FGF5 Gene

Domains & Families for FGF5 Gene

Gene Families for FGF5 Gene

Suggested Antigen Peptide Sequences for FGF5 Gene

Graphical View of Domain Structure for InterPro Entry

P12034

UniProtKB/Swiss-Prot:

FGF5_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF5: view

Function for FGF5 Gene

Molecular function for FGF5 Gene

GENATLAS Biochemistry:
fibroblast growth factor 5,basic,HST oncogene homolog,expressed by fibroblasts,epithelium and during embryonic development mitogenic for fibroblast
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).

Gene Ontology (GO) - Molecular Function for FGF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IDA 8386828
GO:0008083 growth factor activity IEA --
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS --
genes like me logo Genes that share ontologies with FGF5: view
genes like me logo Genes that share phenotypes with FGF5: view

Human Phenotype Ontology for FGF5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGF5 Gene

MGI Knock Outs for FGF5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF5 Gene

Localization for FGF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF5 Gene COMPARTMENTS Subcellular localization image for FGF5 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FGF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 9786939
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with FGF5: view

Pathways & Interactions for FGF5 Gene

SuperPathways for FGF5 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI-3K cascade-FGFR3
4 SHC-mediated cascade-FGFR4
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF5: view

SIGNOR curated interactions for FGF5 Gene

Activates:

Gene Ontology (GO) - Biological Process for FGF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007267 cell-cell signaling TAS 9786939
GO:0007399 nervous system development TAS 9786939
GO:0008283 cell proliferation TAS 3211147
GO:0008284 positive regulation of cell proliferation IGI 8663044
genes like me logo Genes that share ontologies with FGF5: view

Drugs & Compounds for FGF5 Gene

(3) Drugs for FGF5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 779,250

(2) Additional Compounds for FGF5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF5: view

Transcripts for FGF5 Gene

Unigene Clusters for FGF5 Gene

Fibroblast growth factor 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF5 Gene

No ASD Table

Relevant External Links for FGF5 Gene

GeneLoc Exon Structure for
FGF5
ECgene alternative splicing isoforms for
FGF5

Expression for FGF5 Gene

mRNA expression in normal human tissues for FGF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF5 Gene

This gene is overexpressed in Brain - Cerebellum (x6.1) and Brain - Cerebellar Hemisphere (x6.0).

Protein differential expression in normal tissues from HIPED for FGF5 Gene

This gene is overexpressed in Platelet (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF5 Gene



Protein tissue co-expression partners for FGF5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGF5 Gene:

FGF5

SOURCE GeneReport for Unigene cluster for FGF5 Gene:

Hs.37055

mRNA Expression by UniProt/SwissProt for FGF5 Gene:

P12034-FGF5_HUMAN
Tissue specificity: Expressed in neonatal brain.
genes like me logo Genes that share expression patterns with FGF5: view

Primer Products

Orthologs for FGF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGF5 34
  • 89.38 (n)
  • 88.45 (a)
FGF5 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF5 34
  • 86.45 (n)
  • 85.26 (a)
FGF5 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf5 34
  • 84.08 (n)
  • 87.04 (a)
Fgf5 16
Fgf5 35
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGF5 34
  • 99.5 (n)
  • 99.25 (a)
FGF5 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf5 34
  • 85.41 (n)
  • 86.35 (a)
oppossum
(Monodelphis domestica)
Mammalia FGF5 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF5 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF5 34
  • 65.45 (n)
  • 71.2 (a)
FGF5 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF5 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf5 34
  • 73.47 (n)
  • 77.04 (a)
zebrafish
(Danio rerio)
Actinopterygii fgf5 34
  • 66.31 (n)
  • 70.27 (a)
fgf5 35
  • 63 (a)
OneToOne
Species where no ortholog for FGF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF5 Gene

ENSEMBL:
Gene Tree for FGF5 (if available)
TreeFam:
Gene Tree for FGF5 (if available)

Paralogs for FGF5 Gene

(15) SIMAP similar genes for FGF5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGF5: view

Variants for FGF5 Gene

Sequence variations from dbSNP and Humsavar for FGF5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs33950145 - 80,266,984(+) GCGCT(A/C/G)TGTCT upstream-variant-2KB, reference, missense
rs587777581 Trichomegaly (TCMGLY) 80,286,385(+) ATACC(C/G/T)ATGCC reference, missense, utr-variant-3-prime
rs716678 -- 80,268,981(-) GTCAA(A/G)AGACC intron-variant
rs1047245 -- 80,266,741(+) GGCAG(A/C)GCCAG upstream-variant-2KB, utr-variant-5-prime
rs1047247 -- 80,266,949(+) CCCTA(G/T)AGGCT upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FGF5 Gene

Variant ID Type Subtype PubMed ID
esv3893966 CNV loss 25118596

Variation tolerance for FGF5 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF5 Gene

Human Gene Mutation Database (HGMD)
FGF5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF5 Gene

Disorders for FGF5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FGF5 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
trichomegaly
  • familial isolated trichomegaly
kaposi sarcoma
  • kaposi sarcoma, susceptibility to
hereditary spherocytosis
  • congenital spherocytic hemolytic anemia
- elite association - COSMIC cancer census association via MalaCards
Search FGF5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGF5_HUMAN
  • Trichomegaly (TCMGLY) [MIM:190330]: A morphologic trait characterized by unusually long eyelashes and mild hypertrichosis of eyebrows. It can be observed in association with corneal irritation, cataracts, and hereditary spherocytosis. {ECO:0000269 PubMed:24989505}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FGF5

Genetic Association Database (GAD)
FGF5
Human Genome Epidemiology (HuGE) Navigator
FGF5
Tumor Gene Database (TGDB):
FGF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF5
genes like me logo Genes that share disorders with FGF5: view

No data available for Genatlas for FGF5 Gene

Publications for FGF5 Gene

  1. Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas. (PMID: 11454700) Hanada K.-I. … Yang J.C. (Cancer Res. 2001) 3 4 22 65
  2. Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes. (PMID: 10823842) de Vries C.J.M. … Pannekoek H. (J. Biol. Chem. 2000) 3 4 22 65
  3. Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. (PMID: 1700424) Haub O. … Goldfarb M. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 22 65
  4. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. (PMID: 3211147) Zhan X. … Goldfarb M. (Mol. Cell. Biol. 1988) 2 3 4 65
  5. FGF5 is a crucial regulator of hair length in humans. (PMID: 24989505) Higgins C.A. … Christiano A.M. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 4 65

Products for FGF5 Gene

Sources for FGF5 Gene

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