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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF4 Gene

protein-coding   GIFtS: 68
GCID: GC11M069588

fibroblast growth factor 4

(Previous name: heparin secretory transforming protein 1 )
(Previous symbol: HSTF1)
 Explore 50 diseases affiliated with
FGF4 via
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Biological research products
for FGF4    

Aliases
for FGF4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fibroblast Growth Factor 41 2     Heparin-Binding Growth Factor 42 3
HSTF11 2 3 5     Transforming Protein KS32 3
HBGF-41 2 3     FGF-42 3
HST1 2 3     HSTF-12 3
HST-11 2 3     Fibroblast Growth Factor 4 Splice Isoform2
K-FGF1 2     Human Stomach Cancer, Transforming Factor From FGF-Related Oncogene2
KFGF1 2     Kaposi Sarcoma Oncogene2
Heparin Secretory Transforming Protein 11 2     Oncogene HST2
Heparin Secretory-Transforming Protein 12 3     KS33

External Ids:    HGNC: 36821   Entrez Gene: 22492   Ensembl: ENSG000000753887   OMIM: 1649805   UniProtKB: P086203   

Export aliases for FGF4 gene to outside databases

Previous GC identifers: GC11M072083 GC11M071274 GC11M069835 GC11M069361 GC11M069362 GC11M069297 GC11M065883


Summaries
for FGF4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FGF4:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess
broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic
development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its
oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on
chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog
suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FGF4_HUMAN, P08620
Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell
differentiation. Required for normal limb and cardiac valve development during embryogenesis

Gene Wiki entry for FGF4


Genomic Views
for FGF4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF4 gene promoter:
         COUP-TF1   COUP-TF   MyoD   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGF4 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13.3

FGF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M069588:  view genomic region     (about GC identifiers)

Start:
 69,587,797 bp from pter      End:
 69,590,171 bp from pter
Size:
 2,375 bases      Orientation:
 minus strand

Proteins
for FGF4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FGF4_HUMAN, P08620 (See protein sequence)
Recommended Name: Fibroblast growth factor 4 precursor  
Size: 206 amino acids; 22048 Da
Subunit: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their
receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
Subcellular location: Secreted (Potential)
1 PDB 3D structure from and Proteopedia for FGF4:
1IJT (3D)    

Explore the universe of human proteins at neXtProt for FGF4: NX_P08620

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08620

    • FGF4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001998.1  
    ENSEMBL proteins: 
     ENSP00000168712  
    Reactome Protein details: P08620
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant FGF4 Protein
    R&D Systems Recombinant & Natural Proteins for FGF4 (FGF-4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: FGF4
    OriGene Protein Over-expression Lysate: FGF4
    OriGene Custom Protein Services for FGF4 
    GenScript Purified and Recombinant Proteins for FGF4
    Novus Biologicals FGF4 Proteins
    Novus Biologicals FGF4 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for FGF4
    Uscn Proteins for FGF4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005625soluble fraction ----
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--


    FGF4 for ontologies           About GeneDecksing



    FGF4 Antibody Products: 
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    ThermoFisher Antibody for FGF4

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    Uscn ELISAs and CLIAs for FGF4

    Protein Domains /
    Families
    for FGF4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FGF4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry P08620

    ProtoNet protein and cluster: P08620

    2 Blocks protein families:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF4_HUMAN, P08620
    Similarity: Belongs to the heparin-binding growth factors family


    Function
    for FGF4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FGF4_HUMAN, P08620
    Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell
    differentiation. Required for normal limb and cardiac valve development during embryogenesis

         Genatlas biochemistry entry for FGF4:
    fibroblast growth factor 4,basic,HST oncogene homolog,controlling limb development at the proximodistal axis,involved
    in anteroposterior polarization of the bud through a positive feedback loop controlled by SHH expression,expressed in
    ectoderm under SHH control

         Summary:  
    During embryonic development, FGF4 as signaling molecule is secreted from the following cells: Apical Ectodermal Ridge Cells in Limb Ectoderm, Epiblast Cells in Epiblast (see all 8).

    It affects the following cells: Early Tenocyte Cells in Limb Tendon Primordia, Endocardial Cushion Cells in Atrioventricular Endocardial Cushion (see all 8).

    FGF4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Hepatocyte-like cells, Epithelial Podocyte-like cells (see all 4).

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF4
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF4 (see all 13):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-767-5p hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FGF4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF4 (see all 7)
    OriGene shRNA RFP: FGF4
    OriGene siRNA: FGF4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FGF4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FGF4 (NM_002007)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF4 

    Cell Line
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    Search LifeMap BioReagents cell lines for FGF4

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FGF4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IEA--
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--


    FGF4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FGF4:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for FGF4: Fgf4tm1.3Mrt Fgf4tm1.1Mrc Fgf4tm2Mrc Fgf4tm1Bas Fgf4tm1Gol
         5 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Fgf4):
     limbs/digits/tail  mortality/aging  normal  respiratory system  skeleton 

    FGF4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FGF4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/32 super-pathways (see all 32) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1FGFR2c binds to FGF
    8/17 pathways (see all 17)
    		FGFR2c binds to FGF1.00
    		FGFR4 ligand binding and activation0.73
    		FGFR2c ligand binding and activation1.00
    		FGFR1c ligand binding and activation0.71
    		FGFR3c ligand binding and activation0.79
    		Signaling by activated point mutants of FGFR10.71
    		FGFR3 ligand binding and activation0.79
    		FGFR1 ligand binding and activation0.59
    2Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    3Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    4PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    5IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for FGF4
        Selected targets of Oct-3/4
    Development FGF-family signaling

    5/61 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF4 (see all 61)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF4
        Development FGF-family signaling

    3 BioSystems Pathways for FGF4 
        MAPK signaling pathway
    Regulation of Actin Cytoskeleton
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    5/57        Reactome Pathways for FGF4 (see all 57)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    4         Kegg Pathways  (Kegg details for FGF4):
        MAPK signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Melanoma


    FGF4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/22 Interacting proteins for FGF4 (P086202, 3 ENSP000001687124) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR2P218022, 3, ENSP000004102944MINT-8400532 I2D: score=1 STRING: ENSP00000410294
    FGFR3P226073, ENSP000002607954I2D: score=1 STRING: ENSP00000260795
    FGFR4P224553, ENSP000002924084I2D: score=2 STRING: ENSP00000292408
    FGFR1P113623, ENSP000003802804I2D: score=1 STRING: ENSP00000380280
    NRP1O147863, ENSP000002653714I2D: score=1 STRING: ENSP00000265371
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0007165signal transduction TAS2959959
    GO:0007267cell-cell signaling TAS2959959
    GO:0008284positive regulation of cell proliferation IGI8663044


    FGF4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FGF4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF4

    1 HMDB Compound for FGF4    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    1 DrugBank Compound for FGF4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pentosan Polysulfate-- 37300-21-3targetinhibitor8738610 1708834 1279186

    10/17 Novoseek chemical compound relationships for FGF4 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 46.1 37 9715278 (6), 19277121 (6), 9692555 (2), 8805369 (2) (see all 11)
    heparin 38.9 22 10512728 (4), 11486033 (4), 8737809 (1), 9662260 (1) (see all 12)
    heparan sulfate 32.9 12 10512728 (3), 1379245 (1), 17143873 (1), 19937756 (1)
    vegf 27.8 13 9407972 (2), 14996996 (2), 14504053 (1), 16377203 (1) (see all 9)
    matrigel 26.9 3 17702985 (1), 17407703 (1), 18535293 (1)
    retinoid 26.4 1 9715278 (1)
    tyrosine 20.4 2 17702985 (1), 10633078 (1)
    tamoxifen 18.2 3 7881095 (1), 9366526 (1), 8481920 (1)
    tgf beta1 16.2 1 11743396 (1)
    neomycin 14.8 3 9715278 (2)

    Search CenterWatch for drugs/clinical trials and news about FGF4 

    Transcripts
    for FGF4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FGF4 gene: 
    NM_002007.2  

    Unigene Cluster for FGF4:

    Fibroblast growth factor 4
    Hs.1755  [show with all ESTs]
    Unigene Representative Sequence: NM_002007
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000168712(uc001opg.1 uc010rqj.1) ENST00000538040

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF4 (see all 13):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-767-5p hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FGF4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF4 (see all 7)
    OriGene shRNA RFP: FGF4
    OriGene siRNA: FGF4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FGF4 (NM_002007)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FGF4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF4

    Additional cDNA sequence: 

    FJ456981.1 M17446.1 

    1 DOTS entry:

    DT.86859343 

    2 AceView cDNA sequences:

    M17446 NM_002007 

    GeneLoc Exon Structure


    Expression
    for FGF4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGGTCACCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FGF4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb EctodermApical Ectodermal Ridge CellsDermis, Ectoderm
    BoneFacial SuturesFacial Presumptive Suture CellsBone
    BoneRostral SuturesRostral Presumptive Suture CellsBone
    EpiblastEpiblastEpiblast CellsEarly Embryo
    EpiblastEpiblastIntraembryonic Epiblast CellsEarly Embryo
    HeartAtrioventricular Endocardial CushionEndocardial Cushion CellsEndocardium
    Inner Cell MassInner Cell MassInner Cell Mass CellsEarly Embryo
    LimbAutopodMesenchymal Condensate CellsBone, Cartilage
    LimbStylopodMesenchymal Condensate CellsBone, Cartilage
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    Induced pluripotent stem cell line 201B6 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    HSF-1 (UC01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Induced pluripotent stem cell line 253G1 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    FES22 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    FES29 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Mesendoderm-like cells (A scalable, suspensi...)
    Mesendoderm-like cells (Generation of beta c...)

    See FGF4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF4

    SOURCE GeneReport for Unigene cluster: Hs.1755
        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF4 (see all 6): 
              Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    Orthologs
    for FGF4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FGF4 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FGF41 fibroblast growth factor 4 71.03(n)
    71.2(a)    		   428857  NM_001031546.1  NP_001026717.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FGF46
    		 --
    		 67(a)
    		 1 ↔ 1
    		 1(55189348-55203114)
    African clawed frog
    (Xenopus laevis)    		 Amphibia fgfe-A2 embryonic Fibroblast growth factor 73.71(n)    X62593.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fgf42 fibroblast growth factor 4 72(n)   60311  AF283555.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea let-7566
    		 Protein let-756
    		 12(a)
    		 1 → many
    		 III(6407076-6409965)


    ENSEMBL Gene Tree for FGF4 (if available)
    TreeFam Gene Tree for FGF4 (if available) 

    Paralogs
    for FGF4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF4 gene
    FGF122  FGF52  FGF202  FGF162  FGF92  FGF62  FGF32  FGF72  
    FGF112  FGF102  FGF222  FGF132  FGF142  
    15 SIMAP similar genes for FGF4 using alignment to 1 protein entry:     FGF4_HUMAN:
    FGF6    FGF7    FGF9    FGF10    FGF13    FGF14
    FGF2    FGF12    FGF16    FGF20    FGF5    FGF11
    FGF1    FGF22    FGF3

    FGF4 for paralogs           About GeneDecksing



    Genomic Variants
    for FGF4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/85 NCBI SNPs in FGF4 are shown (see all 85)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1868138921,2
    		--69587346(+) TTCCTC/GTCCAT 1 -- ds50010--------
    rs38327181,2
    		C,--69587349(-) TCCAT-/TGGAGA 1 -- ds50010--------
    rs1916767021,2
    		--69587372(+) GCTTCA/GTCTTT 1 -- ds50010--------
    rs1839185111,2
    		--69587373(+) CTTCGC/TCTTTT 1 -- ds50010--------
    rs1887161611,2
    		--69587374(+) TTCGTC/TTTTTC 1 -- ds50010--------
    rs1911516171,2
    		--69587473(+) TAGATC/TGAGGA 1 -- ds50010--------
    rs1169546811,2
    		F,--69587579(+) AAACCG/AATATG 1 -- ds50011Minor allele frequency- A:0.02EA 120
    rs37406401,2
    		C,F,H,--69587583(-) GGGACA/GTATCG 1 -- ds500139Minor allele frequency- G:0.25EA NA NS CSA WA 5420
    rs1157083231,2
    		F,--69587647(+) AGCCAA/GGCCTG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1403291611,2
    		--69587711(+) TGCTCC/TACGCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGF4 (69587797 - 69590171 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FGF4
         1 CNV: 4755

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    Disorders / Diseases
    for FGF4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FGF4 for disorders           About GeneDecksing

    OMIM gene information: 164980    OMIM disorders: --

    20/50 diseases for FGF4 (see all 50):    About MalaCards
    kaposi's sarcoma    stomach cancer    sarcoma    critical limb ischemia
    germ cell tumor    testicular germ cell tumor    male germ cell tumor    pituitary adenoma
    urinary bladder cancer    squamous cell carcinoma of the head and neck    prolactinoma    craniosynostosis
    squamous cell carcinoma    pituitary tumor    chronic lymphocytic leukemia    acute myeloid leukemia
    germ cell cancer    synostosis    teratocarcinoma    hemangioma

    2 diseases from the University of Copenhagen DISEASES database for FGF4:
    Embryonal carcinoma     Polydactyly

    10/34 Novoseek disease relationships for FGF4 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 71.9 31 11764380 (2), 7969117 (2), 9715278 (2), 16523502 (2) (see all 17)
    teratocarcinoma 52.9 1 11764380 (1)
    prolactinoma 44 15 9509064 (4), 17287403 (2), 8550832 (2), 8100831 (1)
    pituitary tumors 35.9 3 19359387 (1), 8550832 (1)
    apert syndrome 35.7 1 11596961 (1)
    craniosynostosis 35.1 1 17632770 (1)
    germ cell cancer 33.2 3 9715278 (2)
    esophageal carcinoma 31.1 2 2157713 (1), 2098274 (1)
    seminoma 29.3 2 11764380 (1), 16424014 (1)
    pituitary adenoma 26.9 4 8254924 (1), 17287403 (1), 9509064 (1)

    Human Genome Epidemiology (HuGE) Navigator: FGF4 (7 documents)
    Tumor Gene Database (TGDB): FGF4

    Export disorders for FGF4 gene to outside databases

    Publications
    for FGF4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF4 gene, integrated from 9 sources (see all 327):
    (articles sorted by number of sources associating them with FGF4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. (PubMed id 11486033)1, 2, 9 Bellosta P.... Mohammadi M. (2001)
    2. Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)1, 2 Ornitz D.M....Goldfarb M. (1996)
    3. Localization of the 5' end of the MCF2 oncogene to hu man chromosome 15q15----q23. (PubMed id 1611909)1, 3 Galland F....Birnbaum D. (1992)
    4. Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. (PubMed id 2959959)1, 2 Yoshida T.... Sugimura T. (1987)
    5. An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. (PubMed id 2957062)1, 2 Delli-Bovi P....Basilico C. (1987)
    6. cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. (PubMed id 2953031)1, 2 Taira M....Sugimura T. (1987)
    7. Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self- renewal. (PubMed id 18192227)1, 9 Mayshar Y.... Benvenisty N. (2008)
    8. The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells. (PubMed id 12841847)1, 9 Wang P....Jin T. (2003)
    9. FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner. (PubMed id 19277121)1, 9 Johannesson M....Semb H. (2009)
    10. FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells. (PubMed id 17852409)1, 9 Farre J....Bayes-Genis A. (2007)

    External Searches for FGF4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FGF4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2249 HGNC: 3682 AceView: FGF4 Ensembl:ENSG00000075388 euGenes: HUgn2249
    ECgene: FGF4 Kegg: 2249 H-InvDB: FGF4

    Other Databases showing FGF4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FGF4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FGF4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FGF4 gene:
    Search GeneIP for patents involving FGF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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