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FGF4 Gene

protein-coding   GIFtS: 67
GCID: GC11M069588

Fibroblast Growth Factor 4

(Previous name: heparin secretory transforming protein 1)
(Previous symbol: HSTF1)
  See FGF4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 41 2     HST-12 3
HSTF11 2 3 5     HSTF-12 3
Transforming Protein KS31 2 3     Human Stomach Cancer1
Heparin Secretory Transforming Protein 11 2     Transforming Factor From FGF-Related Oncogene1
Kaposi Sarcoma Oncogene1 2     K-FGF2
Heparin Secretory-Transforming Protein 12 3     KFGF2
Heparin-Binding Growth Factor 42 3     Fibroblast Growth Factor 4 Splice Isoform2
FGF-42 3     Human Stomach Cancer, Transforming Factor From FGF-Related Oncogene2
HBGF-42 3     Oncogene HST2
HST2 3     KS33

External Ids:    HGNC: 36821   Entrez Gene: 22492   Ensembl: ENSG000000753887   OMIM: 1649805   UniProtKB: P086203   

Export aliases for FGF4 gene to outside databases

Previous GC identifers: GC11M072083 GC11M071274 GC11M069835 GC11M069361 GC11M069362 GC11M069297 GC11M065883


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF4 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities and are involved in a variety of biological processes
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene
was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are
located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors.
Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic
hedgehog (SHH) signaling pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF4 Gene:
FGF4 (fibroblast growth factor 4) is a protein-coding gene. Diseases associated with FGF4 include gallbladder squamous cell carcinoma, and stomach cancer. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF4_HUMAN, P08620
Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell
differentiation. Required for normal limb and cardiac valve development during embryogenesis

Gene Wiki entry for FGF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF4 gene promoter:
         COUP-TF1   COUP-TF   MyoD   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF4 promoter sequence
   Search Chromatin IP Primers for FGF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13.3

FGF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M069588:  view genomic region     (about GC identifiers)

Start:
69,587,797 bp from pter      End:
69,590,171 bp from pter
Size:
2,375 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FGF4_HUMAN, P08620 (See protein sequence)
Recommended Name: Fibroblast growth factor 4 precursor  
Size: 206 amino acids; 22048 Da
Subunit: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their
receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
1 PDB 3D structure from and Proteopedia for FGF4:
1IJT (3D)    
Secondary accessions: B7U994
Alternative splicing: 2 isoforms:  P08620-1   P08620-2   (Antagonist of isoform 1, shutting down FGF4-induced Erk1/2 phosphorylation)

Explore the universe of human proteins at neXtProt for FGF4: NX_P08620

Explore proteomics data for FGF4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001998.1  
    ENSEMBL proteins: 
     ENSP00000168712  
    Reactome Protein details: P08620

    FGF4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FGF4

     
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    antibodies-online proteins for FGF4 (31 products) 

     
    antibodies-online peptides for FGF4

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    antibodies-online antibodies for FGF4 (76 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam
     IPR028239 FGF4

    Graphical View of Domain Structure for InterPro Entry P08620

    ProtoNet protein and cluster: P08620

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF4_HUMAN, P08620
    Similarity: Belongs to the heparin-binding growth factors family


    Find genes that share domains with FGF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF4_HUMAN, P08620
    Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell
    differentiation. Required for normal limb and cardiac valve development during embryogenesis

         Genatlas biochemistry entry for FGF4:
    fibroblast growth factor 4,basic,HST oncogene homolog,controlling limb development at the proximodistal
    axis,involved in anteroposterior polarization of the bud through a positive feedback loop controlled by SHH
    expression,expressed in ectoderm under SHH control

         Summary: 
    During embryonic development, FGF4 as signaling molecule is secreted from the following cells:
          selected tissues (see all 4)      fully expand
    Limb: Apical Ectodermal Ridge Cells (Limb Ectoderm), Mononuclear Myocytes (Forelimb Dorsal Muscles)      fully expand to see all 5 cells
    Epiblast: Epiblast Cells (Epiblast)

    It affects the following cells:
          selected tissues (see all 8)
    Bone: Presumptive Suture Cells (Facial Sutures), Presumptive Suture Cells (Rostral Sutures)       to see all 2 cells
    Gut Tube: Hindgut Endoderm Cells (Hindgut), Primitive Gut Endoderm Cells (Gut Tube)       to see all 2 cells

    FGF4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 3)      
    Liver: Hepatocyte-like cells, Immature hepatocytes       to see all 2 cells
    Heart: Cardiomyocyte-like cells, Cardiomyocyte-like cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IEA--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with FGF4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FGF4:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Fgf4):
     limbs/digits/tail  mortality/aging  normal  respiratory system  skeleton 

    Find genes that share phenotypes with FGF4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FGF4: Fgf4tm1.3Mrt Fgf4tm1.1Mrc Fgf4tm2Mrc Fgf4tm1Bas Fgf4tm1Gol

       genOway: Develop your customized and physiologically relevant rodent model for FGF4

    miRNA
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    miRTarBase miRNAs that target FGF4:
    hsa-mir-335-5p (MIRT018466)

    Block miRNA regulation of human, mouse, rat FGF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF4 (see all 13):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-767-5p hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p
    SwitchGear 3'UTR luciferase reporter plasmidFGF4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FGF4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: FGF4 (NM_002007)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF4

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    Browse ESI BIO Cell Lines and PureStem Progenitors for FGF4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF4_HUMAN, P08620: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol2
    nucleus2
    endoplasmic reticulum1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with FGF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF4 About   (see all 36)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR4 ligand binding and activation0.00
    SHC-mediated cascade0.79
    FGFR1 ligand binding and activation0.00
    FGFR2 ligand binding and activation0.74
    Activated point mutants of FGFR20.00
    FRS2-mediated cascade0.70
    Signaling by FGFR2 mutants0.00
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    5PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72


    Find genes that share SuperPaths with FGF4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF4 (see all 61)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF4
        Development FGF-family signaling

    3 BioSystems Pathways for FGF4
        MAPK signaling pathway
    Regulation of Actin Cytoskeleton
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    Selected Reactome Pathways for FGF4 (see all 17)
        Signaling by activated point mutants of FGFR1
    FRS2-mediated cascade
    FGFR4 ligand binding and activation
    Negative regulation of FGFR signaling
    Activated point mutants of FGFR2


    Selected Kegg Pathways  (Kegg details for FGF4) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF4 (see all 6): 
              Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for FGF4 (P086203 ENSP000001687124) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR2P218023, ENSP000004102944I2D: score=1 STRING: ENSP00000410294
    FGFR3P226073, ENSP000002607954I2D: score=1 STRING: ENSP00000260795
    FGFR4P224553, ENSP000002924084I2D: score=2 STRING: ENSP00000292408
    FGFR1P113623, ENSP000003802804I2D: score=1 STRING: ENSP00000380280
    NRP1O147863, ENSP000002653714I2D: score=1 STRING: ENSP00000265371
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0007165signal transduction TAS2959959
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007267cell-cell signaling TAS2959959

    Find genes that share ontologies with FGF4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF4

    1 HMDB Compound for FGF4    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    1 DrugBank Compound for FGF4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pentosan Polysulfate-- 37300-21-3targetinhibitor8738610 1708834 1279186

    Selected Novoseek inferred chemical compound relationships for FGF4 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 46.1 37 9715278 (6), 19277121 (6), 9692555 (2), 8805369 (2) (see all 11)
    heparin 38.9 22 10512728 (4), 11486033 (4), 8737809 (1), 9662260 (1) (see all 12)
    heparan sulfate 32.9 12 10512728 (3), 1379245 (1), 17143873 (1), 19937756 (1)
    vegf 27.8 13 9407972 (2), 14996996 (2), 14504053 (1), 16377203 (1) (see all 9)
    matrigel 26.9 3 17702985 (1), 17407703 (1), 18535293 (1)
    retinoid 26.4 1 9715278 (1)
    tyrosine 20.4 2 17702985 (1), 10633078 (1)
    tamoxifen 18.2 3 7881095 (1), 9366526 (1), 8481920 (1)
    tgf beta1 16.2 1 11743396 (1)
    neomycin 14.8 3 9715278 (2)



    Find genes that share compounds with FGF4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGF4 gene: 
    NM_002007.2  

    Unigene Cluster for FGF4:

    Fibroblast growth factor 4
    Hs.1755  [show with all ESTs]
    Unigene Representative Sequence: NM_002007
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000168712(uc001opg.1 uc010rqj.1) ENST00000538040
    miRNA
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    GenScript: all cDNA clones in your preferred vector: FGF4 (NM_002007)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF4
      QuantiTect SYBR Green Assays in human, mouse, rat FGF4
      QuantiFast Probe-based Assays in human, mouse, rat FGF4

    Additional mRNA sequence: 

    FJ456981.1 M17446.1 

    1 DOTS entry:

    DT.86859343 

    2 AceView cDNA sequences:

    M17446 NM_002007 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FGF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTCACCC
    FGF4 Expression
    About this image


    FGF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 9 entries
             Inner Cell Mass Cells Inner Cell Mass
             201B6
     
     Limb (Muscoskeletal System)    fully expand to see all 5 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
             Limb Ectoderm
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Presumptive Suture Cells Rostral Sutures
             Bone marrow-derived mesenchymal stem cells
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 3 entries
             Primitive Streak Cells Posterior Primitive Streak
             Primitive streak-like cells
     
     Epiblast (Early Embryo)    fully expand to see all 2 entries
             Primitive Streak Cells Posterior Primitive Streak
    FGF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1755
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF4 (see all 6): 
              Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat FGF4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf41 , 5 fibroblast growth factor 41, 5 84.78(n)1
    87.28(a)1
      7 (88.88 cM)5
    141751  NM_010202.51  NP_034332.21 
     1448613865 
    chicken
    (Gallus gallus)
    Aves FGF41 fibroblast growth factor 4 73.63(n)
    75.95(a)
      428857  NM_001031546.1  NP_001026717.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF46
    fibroblast growth factor 4
    70(a)
    1 ↔ 1
    1(55189348-55203114)
    African clawed frog
    (Xenopus laevis)
    Amphibia fgfe-A2 embryonic Fibroblast growth factor 73.71(n)    X62593.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf42 fibroblast growth factor 4 72(n)   60311  AF283555.1 


    ENSEMBL Gene Tree for FGF4 (if available)
    TreeFam Gene Tree for FGF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF4 gene
    FGF122  FGF162  FGF52  FGF202  FGF62  FGF92  FGF32  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    15 SIMAP similar genes for FGF4 using alignment to 1 protein entry:     FGF4_HUMAN:
    FGF6    FGF7    FGF9    FGF10    FGF13    FGF14
    FGF2    FGF12    FGF16    FGF20    FGF5    FGF11
    FGF1    FGF22    FGF3

    Find genes that share paralogs with FGF4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF4 (see all 104)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868138921,2
    --69587346(+) TTCCTC/GTCCAT 1 -- ds50010--------
    rs38327181,2
    C--69587349(-) TCCAT-/TGGAGA 1 -- ds50010--------
    rs1916767021,2
    --69587372(+) GCTTCA/GTCTTT 1 -- ds50010--------
    rs1839185111,2
    --69587373(+) CTTCGC/TCTTTT 1 -- ds50010--------
    rs1887161611,2
    --69587374(+) TTCGTC/TTTTTC 1 -- ds50010--------
    rs1911516171,2
    C--69587473(+) TAGATC/TGAGGA 1 -- ds50010--------
    rs1169546811,2
    F--69587579(+) AAACCG/AATATG 1 -- ds50011Minor allele frequency- A:0.02EA 120
    rs37406401,2
    C,F,H--69587583(-) GGGACA/GTATCG 1 -- ds500139Minor allele frequency- G:0.25EA NA NS CSA WA 5420
    rs1157083231,2
    F--69587647(+) AGCCAA/GGCCTG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1403291611,2
    C--69587711(+) TGCTCC/TACGCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGF4 (69587797 - 69590171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FGF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832200CNV Loss17160897
    dgv16n68CNV Loss17160897
    nsv508640CNV Loss20534489
    nsv825973CNV Gain20364138
    nsv832199CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF4
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164980    OMIM disorders: --

    5 diseases for FGF4:    
    About MalaCards
    gallbladder squamous cell carcinoma    stomach cancer    kaposi's sarcoma    male germ cell tumor
    sarcoma

    4 diseases from the University of Copenhagen DISEASES database for FGF4:
    Embryonal carcinoma     Polydactyly     Esophageal cancer     Gallbladder squamous cell carcinoma

    Find genes that share disorders with FGF4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FGF4 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 71.9 31 11764380 (2), 7969117 (2), 9715278 (2), 16523502 (2) (see all 17)
    teratocarcinoma 52.9 1 11764380 (1)
    prolactinoma 44 15 9509064 (4), 17287403 (2), 8550832 (2), 8100831 (1)
    pituitary tumors 35.9 3 19359387 (1), 8550832 (1)
    apert syndrome 35.7 1 11596961 (1)
    craniosynostosis 35.1 1 17632770 (1)
    germ cell cancer 33.2 3 9715278 (2)
    esophageal carcinoma 31.1 2 2157713 (1), 2098274 (1)
    seminoma 29.3 2 11764380 (1), 16424014 (1)
    pituitary adenoma 26.9 4 8254924 (1), 17287403 (1), 9509064 (1)

    Genetic Association Database (GAD): FGF4
    Human Genome Epidemiology (HuGE) Navigator: FGF4 (7 documents)
    Tumor Gene Database (TGDB): FGF4

    Export disorders for FGF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF4 gene, integrated from 10 sources (see all 328):
    (articles sorted by number of sources associating them with FGF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self- renewal. (PubMed id 18192227)1, 2, 9 Mayshar Y.... Benvenisty N. (Stem Cells 2008)
    2. Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. (PubMed id 11486033)1, 2, 9 Bellosta P.... Mohammadi M. (Mol. Cell. Biol. 2001)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    5. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    6. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    7. Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population. (PubMed id 18510611)1, 4 Ikeda S....Tsugane S. (Am. J. Gastroenterol. 2008)
    8. Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)1, 2 Ornitz D.M.... Goldfarb M. (J. Biol. Chem. 1996)
    9. Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23. (PubMed id 1611909)1, 3 Galland F....Birnbaum D. (Cytogenet. Cell Genet. 1992)
    10. Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. (PubMed id 2959959)1, 2 Yoshida T.... Sugimura T. (Proc. Natl. Acad. Sci. U.S.A. 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2249 HGNC: 3682 AceView: FGF4 Ensembl:ENSG00000075388 euGenes: HUgn2249
    ECgene: FGF4 Kegg: 2249 H-InvDB: FGF4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGF4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF4 gene:
    Search GeneIP for patents involving FGF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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