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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF4 Gene

protein-coding   GIFtS: 67
GCID: GC11M069588

Fibroblast Growth Factor 4

(Previous name: heparin secretory transforming protein 1)
(Previous symbol: HSTF1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibroblast Growth Factor 41 2     HST-12 3
HSTF11 2 3 5     HSTF-12 3
Transforming Protein KS31 2 3     Human Stomach Cancer1
Heparin Secretory Transforming Protein 11 2     Transforming Factor From FGF-Related Oncogene1
Kaposi Sarcoma Oncogene1 2     K-FGF2
Heparin Secretory-Transforming Protein 12 3     KFGF2
Heparin-Binding Growth Factor 42 3     Fibroblast Growth Factor 4 Splice Isoform2
FGF-42 3     Human Stomach Cancer, Transforming Factor From FGF-Related Oncogene2
HBGF-42 3     Oncogene HST2
HST2 3     KS33

External Ids:    HGNC: 36821   Entrez Gene: 22492   Ensembl: ENSG000000753887   OMIM: 1649805   UniProtKB: P086203   

Export aliases for FGF4 gene to outside databases

Previous GC identifers: GC11M072083 GC11M071274 GC11M069835 GC11M069361 GC11M069362 GC11M069297 GC11M065883


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF4 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities and are involved in a variety of biological processes
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene
was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are
located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors.
Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic
hedgehog (SHH) signaling pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF4 Gene: 
FGF4 (fibroblast growth factor 4) is a protein-coding gene. Diseases associated with FGF4 include stomach cancer, and kaposi's sarcoma, and among its related super-pathways are Regulation of actin cytoskeleton and MAPK signaling pathway. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF4_HUMAN, P08620
Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell
differentiation. Required for normal limb and cardiac valve development during embryogenesis

Gene Wiki entry for FGF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF4 gene promoter:
         COUP-TF1   COUP-TF   MyoD   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF4 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13.3

FGF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M069588:  view genomic region     (about GC identifiers)

Start:
69,587,797 bp from pter      End:
69,590,171 bp from pter
Size:
2,375 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FGF4_HUMAN, P08620 (See protein sequence)
Recommended Name: Fibroblast growth factor 4 precursor  
Size: 206 amino acids; 22048 Da
Subunit: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their
receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
Subcellular location: Secreted (Potential)
1 PDB 3D structure from and Proteopedia for FGF4:
1IJT (3D)    

Explore the universe of human proteins at neXtProt for FGF4: NX_P08620

Explore proteomics data for FGF4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08620

  • FGF4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FGF4 Protein Expression
    REFSEQ proteins: NP_001998.1  
    ENSEMBL proteins: 
     ENSP00000168712  
    Reactome Protein details: P08620
    Human Recombinant Protein Products for FGF4: 
    EMD Millipore Purified and/or Recombinant FGF4 Protein
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    Novus Biologicals FGF4 Proteins
    Novus Biologicals FGF4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for FGF4
    Cloud-Clone Corp. Proteins for FGF4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--

    FGF4 for ontologies           About GeneDecksing



    FGF4 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for FGF4 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry P08620

    ProtoNet protein and cluster: P08620

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF4_HUMAN, P08620
    Similarity: Belongs to the heparin-binding growth factors family


    FGF4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF4_HUMAN, P08620
    Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell
    differentiation. Required for normal limb and cardiac valve development during embryogenesis

         Genatlas biochemistry entry for FGF4:
    fibroblast growth factor 4,basic,HST oncogene homolog,controlling limb development at the proximodistal
    axis,involved in anteroposterior polarization of the bud through a positive feedback loop controlled by SHH
    expression,expressed in ectoderm under SHH control

         Summary:
    During embryonic development, FGF4 as signaling molecule is secreted from the following cells: Apical Ectodermal Ridge Cells in Limb Ectoderm, Epiblast Cells in Epiblast (see all 8).

    It affects the following cells: Dental Mesenchymal Cells in Branchial Arch 1, Early Tenocyte Cells in Limb Tendon Primordia (see all 9).

    FGF4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Hepatocyte-like cells from Liver, Early hepatocyte-like cells from (see all).

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IEA--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--
         
    FGF4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FGF4:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Fgf4):
     limbs/digits/tail  mortality/aging  normal  respiratory system  skeleton 

    FGF4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FGF4: Fgf4tm1.3Mrt Fgf4tm1.1Mrc Fgf4tm2Mrc Fgf4tm1Bas Fgf4tm1Gol

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FGF4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FGF4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF4 

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    SwitchGear 3'UTR luciferase reporter plasmidFGF4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of FGF4 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FGF4 About   (see all 35)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Development FGF-family signaling
    Development FGF-family signaling0.63
    FGF Pathway0.38
    4FGFR2c ligand binding and activation
    FGFR ligand binding and activation0.79
    Signaling by activated point mutants of FGFR10.79
    SHC-mediated cascade0.79
    FGFR1c ligand binding and activation0.79
    FGFR2c ligand binding and activation0.79
    FGFR2 ligand binding and activation0.76
    FGFR1 ligand binding and activation0.79
    Signaling by FGFR2 mutants0.76
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for FGF4
        Selected targets of Oct-3/4
    Development FGF-family signaling

    5/61 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF4 (see all 61)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for FGF4
        Development FGF-family signaling

    3 BioSystems Pathways for FGF4
        MAPK signaling pathway
    Regulation of Actin Cytoskeleton
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    5/58        Reactome Pathways for FGF4 (see all 58)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    5/6         Kegg Pathways  (Kegg details for FGF4) (see all 6):
        MAPK signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Proteoglycans in cancer


    FGF4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/22 Interacting proteins for FGF4 (P086203 ENSP000001687124) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR2P218023, ENSP000004102944I2D: score=1 STRING: ENSP00000410294
    FGFR3P226073, ENSP000002607954I2D: score=1 STRING: ENSP00000260795
    FGFR4P224553, ENSP000002924084I2D: score=2 STRING: ENSP00000292408
    FGFR1P113623, ENSP000003802804I2D: score=1 STRING: ENSP00000380280
    NRP1O147863, ENSP000002653714I2D: score=1 STRING: ENSP00000265371
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0007165signal transduction TAS2959959
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007267cell-cell signaling TAS2959959

    FGF4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF4

    1 HMDB Compound for FGF4    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    1 DrugBank Compound for FGF4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pentosan Polysulfate-- 37300-21-3targetinhibitor8738610 1708834 1279186

    10/17 Novoseek inferred chemical compound relationships for FGF4 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 46.1 37 9715278 (6), 19277121 (6), 9692555 (2), 8805369 (2) (see all 11)
    heparin 38.9 22 10512728 (4), 11486033 (4), 8737809 (1), 9662260 (1) (see all 12)
    heparan sulfate 32.9 12 10512728 (3), 1379245 (1), 17143873 (1), 19937756 (1)
    vegf 27.8 13 9407972 (2), 14996996 (2), 14504053 (1), 16377203 (1) (see all 9)
    matrigel 26.9 3 17702985 (1), 17407703 (1), 18535293 (1)
    retinoid 26.4 1 9715278 (1)
    tyrosine 20.4 2 17702985 (1), 10633078 (1)
    tamoxifen 18.2 3 7881095 (1), 9366526 (1), 8481920 (1)
    tgf beta1 16.2 1 11743396 (1)
    neomycin 14.8 3 9715278 (2)

    Search CenterWatch for drugs/clinical trials and news about FGF4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FGF4 gene: 
    NM_002007.2  

    Unigene Cluster for FGF4:

    Fibroblast growth factor 4
    Hs.1755  [show with all ESTs]
    Unigene Representative Sequence: NM_002007
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000168712(uc001opg.1 uc010rqj.1) ENST00000538040
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF4

    Additional mRNA sequence: 

    FJ456981.1 M17446.1 

    1 DOTS entry:

    DT.86859343 

    2 AceView cDNA sequences:

    NM_002007 M17446 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF4 expression in normal human tissues (normalized intensities)      FGF4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTCACCC
    FGF4 Expression
    About this image


    FGF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 8 entries
             Inner Cell Mass Cells Inner Cell Mass
             HSF-1 (UC01)
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Rostral Presumptive Suture Cells Rostral Sutures
             Bone marrow-derived mesenchymal stem cells
     
     Limb (Muscoskeletal System)    fully expand to see all 5 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
             Limb Ectoderm
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 3 entries
             Primitive Streak Cells Primitive Streak
             Mesendoderm-like cells ( Generation of beta cells through a definitive endoderm stage...

    See FGF4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF4

    SOURCE GeneReport for Unigene cluster: Hs.1755
        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF4 (see all 6): 
              Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FGF4 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf41 , 5 fibroblast growth factor 41, 5 82.67(n)1
    81.68(a)1
      7 (88.88 cM)5
    141751  NM_010202.51  NP_034332.21 
     1448613865 
    chicken
    (Gallus gallus)
    Aves FGF41 fibroblast growth factor 4 71.03(n)
    71.2(a)
      428857  NM_001031546.1  NP_001026717.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF46
    Uncharacterized protein
    70(a)
    1 ↔ 1
    1(55189348-55203114)
    African clawed frog
    (Xenopus laevis)
    Amphibia fgfe-A2 embryonic Fibroblast growth factor 73.71(n)    X62593.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf42 fibroblast growth factor 4 72(n)   60311  AF283555.1 


    ENSEMBL Gene Tree for FGF4 (if available)
    TreeFam Gene Tree for FGF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF4 gene
    FGF122  FGF162  FGF52  FGF202  FGF62  FGF92  FGF32  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    15 SIMAP similar genes for FGF4 using alignment to 1 protein entry:     FGF4_HUMAN:
    FGF6    FGF7    FGF9    FGF10    FGF13    FGF14
    FGF2    FGF12    FGF16    FGF20    FGF5    FGF11
    FGF1    FGF22    FGF3

    FGF4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/104 SNPs in FGF4 are shown (see all 104)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868138921,2
    --69587346(+) TTCCTC/GTCCAT 1 -- ds50010--------
    rs38327181,2
    C--69587349(-) TCCAT-/TGGAGA 1 -- ds50010--------
    rs1916767021,2
    --69587372(+) GCTTCA/GTCTTT 1 -- ds50010--------
    rs1839185111,2
    --69587373(+) CTTCGC/TCTTTT 1 -- ds50010--------
    rs1887161611,2
    --69587374(+) TTCGTC/TTTTTC 1 -- ds50010--------
    rs1911516171,2
    C--69587473(+) TAGATC/TGAGGA 1 -- ds50010--------
    rs1169546811,2
    F--69587579(+) AAACCG/AATATG 1 -- ds50011Minor allele frequency- A:0.02EA 120
    rs37406401,2
    C,F,H--69587583(-) GGGACA/GTATCG 1 -- ds500139Minor allele frequency- G:0.25EA NA NS CSA WA 5420
    rs1157083231,2
    F--69587647(+) AGCCAA/GGCCTG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1403291611,2
    C--69587711(+) TGCTCC/TACGCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGF4 (69587797 - 69590171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FGF4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832200CNV Loss17160897
    dgv16n68CNV Loss17160897
    nsv508640CNV Loss20534489
    nsv825973CNV Gain20364138
    nsv832199CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164980    OMIM disorders: --

    20/41 diseases for FGF4 (see all 41):    About MalaCards
    stomach cancer    kaposi's sarcoma    prolactinoma    germ cell cancer
    germ cell tumors    critical limb ischemia    seminoma    craniosynostosis
    synostosis    teratocarcinoma    squamous cell carcinoma of the head and neck    pituitary tumors
    choriocarcinoma    ischemia    testicular cancer    polydactyly
    hemangioma    pituitary adenoma    sarcoma    esophagitis

    4 diseases from the University of Copenhagen DISEASES database for FGF4:
    Embryonal carcinoma     Polydactyly     Esophageal cancer     Gallbladder squamous cell carcinoma

    FGF4 for disorders           About GeneDecksing

    10/34 Novoseek inferred disease relationships for FGF4 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 71.9 31 11764380 (2), 7969117 (2), 9715278 (2), 16523502 (2) (see all 17)
    teratocarcinoma 52.9 1 11764380 (1)
    prolactinoma 44 15 9509064 (4), 17287403 (2), 8550832 (2), 8100831 (1)
    pituitary tumors 35.9 3 19359387 (1), 8550832 (1)
    apert syndrome 35.7 1 11596961 (1)
    craniosynostosis 35.1 1 17632770 (1)
    germ cell cancer 33.2 3 9715278 (2)
    esophageal carcinoma 31.1 2 2157713 (1), 2098274 (1)
    seminoma 29.3 2 11764380 (1), 16424014 (1)
    pituitary adenoma 26.9 4 8254924 (1), 17287403 (1), 9509064 (1)

    Genetic Association Database (GAD): FGF4
    Human Genome Epidemiology (HuGE) Navigator: FGF4 (7 documents)
    Tumor Gene Database (TGDB): FGF4

    Export disorders for FGF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF4 gene, integrated from 9 sources (see all 328):
    (articles sorted by number of sources associating them with FGF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. (PubMed id 11486033)1, 2, 9 Bellosta P.... Mohammadi M. (2001)
    2. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    3. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    4. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
    5. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    6. Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population. (PubMed id 18510611)1, 4 Ikeda S....Tsugane S. (2008)
    7. Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)1, 2 Ornitz D.M....Goldfarb M. (1996)
    8. Localization of the 5' end of the MCF2 oncogene to hu man chromosome 15q15----q23. (PubMed id 1611909)1, 3 Galland F....Birnbaum D. (1992)
    9. Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. (PubMed id 2959959)1, 2 Yoshida T.... Sugimura T. (1987)
    10. An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. (PubMed id 2957062)1, 2 Delli-Bovi P....Basilico C. (1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2249 HGNC: 3682 AceView: FGF4 Ensembl:ENSG00000075388 euGenes: HUgn2249
    ECgene: FGF4 Kegg: 2249 H-InvDB: FGF4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FGF4 gene:
    Search GeneIP for patents involving FGF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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