Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF3 Gene

protein-coding   GIFtS: 62
GCID: GC11M069624

fibroblast growth factor 3

(Previous name: fibroblast growth factor 3 (murine mammary tumor virus...)
(Previous symbol: INT2)
 Explore 48 diseases affiliated with
FGF3 via our new
 Human Malady Compendium 
Biological research products
for FGF3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fibroblast Growth Factor 31 2     FGF-32 3
INT21 2 3 5     INT-2 Proto-Oncogene Protein2
HBGF-31 2 3     Murine Mammary Tumor Virus Integration Site 2, Mouse2
Fibroblast Growth Factor 3 (Murine Mammary Tumor Virus Integration Site
(V-Int-2) Oncogene Homolog)1 2
     Oncogene INT22
Heparin-Binding Growth Factor 32 3     V-INT2 Murine Mammary Tumor Virus Integration Site Oncogene Homolog2
Proto-Oncogene Int-22 3     

External Ids:    HGNC: 36811   Entrez Gene: 22482   Ensembl: ENSG000001868957   OMIM: 1649505   UniProtKB: P114873   

Export aliases for FGF3 gene to outside databases

Previous GC identifers: GC11U990037 GC11M069397 GC11M069333 GC11M065917


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF3:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess
broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic
development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its
similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent
amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and
tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FGF3_HUMAN, P11487
Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell
differentiation. Required for normal ear development

Gene Wiki entry for FGF3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF3 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13

FGF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M069624:  view genomic region     (about GC identifiers)

Start:
69,624,736 bp from pter      End:
69,634,192 bp from pter
Size:
9,457 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FGF3_HUMAN, P11487 (See protein sequence)
Recommended Name: Fibroblast growth factor 3 precursor  
Size: 239 amino acids; 26887 Da
Subunit: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is
increased by heparan sulfate glycosaminoglycans that function as coreceptors
Subcellular location: Secreted (Potential)
Secondary accessions: Q0VG69

Explore the universe of human proteins at neXtProt for FGF3: NX_P11487

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P11487

  • FGF3 Protein expression data from MOPED and PaxDb:    About this image 
    FGF3 Protein Expression
    REFSEQ proteins: NP_005238.1  
    ENSEMBL proteins: 
     ENSP00000334122  
    Reactome Protein details: P11487
    Human Recombinant Protein Products for FGF3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FGF3 (FGF-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: FGF3
    OriGene Custom Protein Services for FGF3 
    GenScript Custom Purified and Recombinant Proteins Services for FGF3
    Novus Biologicals FGF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FGF3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--

    FGF3 for ontologies           About GeneDecksing



    FGF3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FGF3 (FGF-3)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FGF3 
    GenScript Custom Superior Antibodies Services for FGF3
    Novus Biologicals FGF3 Antibodies
    Abcam antibodies for FGF3 
    Uscn Antibodies for FGF3
    ThermoFisher Antibody for FGF3

    Assay Products for FGF3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FGF3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FGF3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FGF3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry P11487

    ProtoNet protein and cluster: P11487

    2 Blocks protein families:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF3_HUMAN, P11487
    Similarity: Belongs to the heparin-binding growth factors family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF3_HUMAN, P11487
    Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell
    differentiation. Required for normal ear development

         Genatlas biochemistry entry for FGF3:
    fibroblast growth factor 3,basic,expressed during embryonic development

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16263090
    GO:0008083growth factor activity IEA--
         
    FGF3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FGF3:
     Decreased TP53 protein express 

         11 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Fgf3):
     behavior/neurological  embryogenesis  growth/size  hearing/vestibular/ear  limbs/digits/tail 
     mortality/aging  nervous system  no phenotypic analysis  normal  reproductive system 
     skeleton 

    FGF3 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for FGF3: Fgf3tm1Sng Fgf3tm1.1Sms Fgf3tm1Mrc
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FGF3 

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FGF3
    SwitchGear 3'UTR luciferase reporter plasmidFGF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF3 (see all 7)
    OriGene shRNA RFP: FGF3
    OriGene siRNA: FGF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF3
    Sirion Biotech Custom design and validation of potent shRNA sequences against FGF3 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FGF3
    Sirion Biotech Customized adenovirus for overexpression of FGF3 
    Sirion Biotech Customized adenovirus for potent knockdown of FGF3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FGF3 (NM_005247)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FGF3
    Search LifeMap BioReagents cell lines for FGF3
    Sirion Biotech Customized stable knockdown cell line services for FGF3 
    Sirion Biotech Customized inducible knockdown cell line services for FGF3
    Sirion Biotech Customized stable overexpressing cell line services for FGF3
    Sirion Biotech Customized inducible overexpressing cell line services for FGF3

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    Signaling by FGFR1.00
    DAP12 signaling0.83
    Downstream signaling of activated FGFR0.92
    Signaling by EGFR in Cancer0.83
    Signaling by FGFR in disease0.91
    DAP12 interactions0.76
    Signaling by ERBB20.89
    Signaling by PDGF0.72
    2PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    PI-3K cascade1.00
    PI3K/AKT activation0.97
    PIP3 activates AKT signaling1.00
    GAB1 signalosome0.96
    PI3K/AKT Signaling in Cancer1.00
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI3K events in ERBB2 signaling1.00
    Signaling by SCF-KIT0.72
    3IRS-related events
    IRS-related events1.00
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    IRS-mediated signalling0.98
    IGF1R signaling cascade0.90
    Insulin receptor signalling cascade0.94
    PI3K Cascade0.84
    IRS-related events triggered by IGF1R0.93
    Signaling by Insulin receptor0.74
    4FGFR2c binds to FGF
    FGFR2 ligand binding and activation0.76
    FGFR ligand binding and activation0.57
    Signaling by FGFR2 mutants0.76
    SHC-mediated cascade0.45
    Activated point mutants of FGFR20.76
    FRS2-mediated cascade0.34
    FGFR1 ligand binding and activation0.59
    Negative regulation of FGFR signaling0.33
    5FGFR2b binds to FGF
    FGFR2b binds to FGF1.00
    FGFR1b ligand binding and activation0.57
    FGFR2b ligand binding and activation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FGF3
        Development FGF-family signaling

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF3
        P2Y Receptor Signaling
    FGF Pathway
    RhoGDI Pathway
    Regulation of eIF4 and p70S6K
    SOCS Pathway

    1 GeneGo (Thomson Reuters) Pathway for FGF3
        Development FGF-family signaling

    1 BioSystems Pathway for FGF3 
        Regulation of Actin Cytoskeleton

    5/50        Reactome Pathways for FGF3 (see all 50)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    4         Kegg Pathways  (Kegg details for FGF3):
        MAPK signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Melanoma


    FGF3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for FGF3 (P114873 ENSP000003341224) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR4P224553, ENSP000002924084I2D: score=2 STRING: ENSP00000292408
    RPS2P158803, ENSP000003418854I2D: score=2 STRING: ENSP00000341885
    FGFR1P113623, ENSP000003802804I2D: score=1 STRING: ENSP00000380280
    FGFR3P226073, ENSP000002607954I2D: score=1 STRING: ENSP00000260795
    EBNA1BP2Q998483, ENSP000002360514I2D: score=3 STRING: ENSP00000236051
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001759organ induction IEA--
    GO:0007165signal transduction TAS2470007
    GO:0007267cell-cell signaling TAS2470007
    GO:0008284positive regulation of cell proliferation IGI8663044
    GO:0008286insulin receptor signaling pathway TAS--

    FGF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF3

    1 HMDB Compound for FGF3    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--
    5 Novoseek chemical compound relationships for FGF3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bamhi 29.1 2 1975511 (1), 1362493 (1)
    vegf 13 8 7519042 (3), 10706099 (1)
    oligonucleotide 0 1 8559598 (1)
    steroid 0 1 1350457 (1)
    agar 0 3 2278877 (2), 8314352 (1)

    Search CenterWatch for drugs/clinical trials and news about FGF3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FGF3 gene: 
    NM_005247.2  

    Unigene Cluster for FGF3:

    Fibroblast growth factor 3
    Hs.37092
    Unigene Representative Sequence: NM_005247
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334134(uc001oph.3)

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FGF3
    SwitchGear 3'UTR luciferase reporter plasmidFGF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF3 (see all 7)
    OriGene shRNA RFP: FGF3
    OriGene siRNA: FGF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF3
    Sirion Biotech Custom design and validation of potent shRNA sequences against FGF3 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FGF3 (NM_005247)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF3 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FGF3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF3

    Additional cDNA sequence: BC113739.1 

    1 DOTS entry:

    DT.95313645 

    1 AceView cDNA sequence:

    NM_005247 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    FGF3 Expression
    About this image
    See FGF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF3

    SOURCE GeneReport for Unigene cluster: Hs.37092
        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF3: 

              Growth Factors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Stem Cells in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FGF3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FGF3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FGF31 fibroblast growth factor 3 69.81(n)
    78.3(a)
      396267  NM_205327.1  NP_990658.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF36
    --
    71(a)
    1 ↔ 1
    1(55137410-55144721)
    African clawed frog
    (Xenopus laevis)
    Amphibia fgf3-A2 Fibroblast growth factor-3 74.28(n)    Z25539.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf32 fibroblast growth factor 3 74.62(n)   30549  NM_131291.1 
    worm
    (Caenorhabditis elegans)
    Secernentea let-7566
    Protein let-756
    12(a)
    1 → many
    III(6407076-6409965)


    ENSEMBL Gene Tree for FGF3 (if available)
    TreeFam Gene Tree for FGF3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF3 gene
    FGF122  FGF52  FGF202  FGF162  FGF42  FGF92  FGF62  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    13 SIMAP similar genes for FGF3 using alignment to 1 protein entry:     FGF3_HUMAN:
    FGF16    FGF10    FGF9    FGF22    FGF20    FGF7
    FGF5    KGFLP1    PRED3    FGF1    FGF6    FGF2
    FGF4

    FGF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/258 NCBI SNPs in FGF3 are shown (see all 258    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219177031,2
    Cpathogenic69625327(-) ACGTGC/TCTGTG 4 P S mis10--------
    rs1219177041,2
    Cpathogenic69631102(-) GGGGAC/TGACTC 4 R * stg10--------
    rs1219177051,2
    Cpathogenic69633506(-) TCAACG/TGCAGC 4 G C mis10--------
    rs1219177061,2
    Cpathogenic69633685(-) CTGGCC/TGCTAC 4 P L mis10--------
    rs794720691,2
    Cother69625447(+) AAACTC/TGCACT 4 K E mis10--------
    rs2012934481,2
    --69624281(+) AAAGT-/AAACTC 2 -- ds50010--------
    rs116025121,2
    C,F,A,H--69624283(+) AGTAAC/ACTCTC 2 -- ds500111Minor allele frequency- A:0.43EA NS WA NA CSA 628
    rs1996071971,2
    --69624283(+) AGTAA-/ACTCTCT 2 -- ds50010--------
    rs1463611981,2
    --69624338(+) CACAC-/ACAG  
            
    ACACA
    1 -- ds50010--------
    rs7457521,2
    --69624341(-) TGTGTG/CTGTGT 2 -- ds50011Minor allele frequency- C:0.50CSA 2

    HapMap Linkage Disequilibrium report for FGF3 (69624736 - 69634192 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FGF3: --
    Human Gene Mutation Database (HGMD): FGF3

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing FGF3:
    Oncogenes & Tumor Suppressor Genes 384HC
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF3
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FGF3 for disorders           About GeneDecksing

    OMIM gene information: 164950   
    OMIM disorders: 610706  
    UniProtKB/Swiss-Prot: FGF3_HUMAN, P11487
  • Defects in FGF3 are a cause of deafness with labyrinthine aplasia, microtia and microdontia (LAMM)
  • [MIM:610706]; also known as congenital deafness with inner ear agenesis, microtia and microdontia. LAMM consists of a
    unique autosomal recessive syndrome characterized by type I microtia, microdontia, and profound congenital deafness
    associated with a complete absence of inner ear structures (Michel aplasia)

    20/48 diseases for FGF3 (see all 48):    About MalaCards
    deafness with labyrinthine aplasia microtia and microdontia (lamm)    cleft lip/palate    inner ear disease    microtia
    hypochondroplasia    testicular germ cell tumor    cleft lip    squamous cell carcinoma
    thanatophoric dysplasia    bladder transitional cell carcinoma    germ cell tumor    gastrointestinal stromal tumor
    transitional cell carcinoma    achondroplasia    ladd syndrome    urinary bladder cancer
    kaposi's sarcoma    oral squamous cell carcinoma    squamous cell carcinoma of the head and neck    giant cell tumor

    1 disease from the University of Copenhagen DISEASES database for FGF3:
    Hypochondroplasia

    10/32 Novoseek disease relationships for FGF3 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypochondroplasia 69.4 2 11057021 (1), 16020314 (1)
    parathyroid diseases 50.7 5 11751068 (2), 9597922 (1)
    allelic loss 47.6 1 8509434 (1)
    mammary tumor 46.9 6 11095248 (1), 1317463 (1), 7679760 (1), 8559598 (1)
    breast cancer 45.6 27 10619258 (2), 7740653 (2), 8585979 (2), 1362493 (2) (see all 17)
    tumors 43.4 42 9316622 (2), 17198565 (2), 12201868 (2), 11568558 (2) (see all 26)
    carcinoma squamous cell 41.6 3 9858651 (1), 2193294 (1), 7685625 (1)
    achondroplasia 41.1 1 11057021 (1)
    breast carcinoma 38.6 9 8100712 (2), 1975511 (1), 1362493 (1), 9329619 (1) (see all 6)
    retinoblastoma 30.4 2 9296509 (1), 16020314 (1)

    Human Genome Epidemiology (HuGE) Navigator: FGF3 (3 documents)
    Tumor Gene Database (TGDB): FGF3

    Export disorders for FGF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF3 gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with FGF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia. (PubMed id 18435799)1, 2, 9 Tekin M....Duman D. (2008)
    2. Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia. (PubMed id 17236138)1, 2, 9 Tekin M....Akar N. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)1, 2 Ornitz D.M....Goldfarb M. (1996)
    5. Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells. (PubMed id 2470007)1, 2 Brooks S.... Peters G. (1989)
    6. Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. (PubMed id 16263090)1, 9 Antoine M....Kiefer P. (2005)
    7. Syndromic congenital sensorineural deafness, microtia and microdontia resulting from a novel homoallelic mutation in fibroblast growth factor 3 (FGF3). (PubMed id 18701883)1, 9 Alsmadi O....Al-Sayed M. (2009)
    8. Regulation of FGF-3 gene expression in tumorigenic and non-tumorigenic clones of a human colon carcinoma cell line. (PubMed id 10749884)1, 9 Galdemard C....Lavialle C. (2000)
    9. SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma. (PubMed id 17656375)1, 9 Gregory-Evans C.Y....Gregory-Evans K. (2007)
    10. Impaired FGF signaling contributes to cleft lip and palate. (PubMed id 17360555)1, 9 Riley B.M....Murray J.C. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2248 HGNC: 3681 AceView: FGF3 Ensembl:ENSG00000186895 euGenes: HUgn2248
    ECgene: FGF3 Kegg: 2248 H-InvDB: FGF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FGF3 gene:
    Search GeneIP for patents involving FGF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FGF3 (FGF-3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for FGF3 (FGF-3)  
     Browse OriGene Antibodies   OriGene shRNA RFP for FGF3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF3  
     OriGene Protein Over-expression Lysate for FGF3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FGF3   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FGF3   OriGene Custom Protein Services for FGF3  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FGF3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF3
     GenScript Custom Purified and Recombinant Proteins Services for FGF3 GenScript cDNA clones with any tag delivered in your preferred vector for FGF3
     GenScript Custom Assay Services for FGF3 GenScript Custom Superior Antibodies Services for FGF3
     GenScript Custom overexpressing Cell Line Services for FGF3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FGF3 promoter
     Search Chromatin IP Primers for FGF3
     RT2 qPCR Primer Assay in human, mouse, rat FGF3
     GNC Network for FGF3
     SABiosciences PCR Arrays including human, mouse, rat FGF3
     Search Tocris compounds for FGF3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FGF3 antibodies
     FGF3 lysates
     Antibodies for FGF3
     See all of Abcam's Antibodies, Kits and Proteins for FGF3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FGF3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FGF3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF3
     SwitchGear 3'UTR luciferase reporter plasmids for FGF3
     SwitchGear Promoter luciferase reporter plasmids for FGF3
     ThermoFisher Antibody for FGF3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF3
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FGF3
    Sirion Biotech Customized:
     stable knockdown cell line services for FGF3
     inducible knockdown cell line services for FGF3
     design and validation of potent shRNA sequences against FGF3
     adenovirus for potent knockdown of FGF3
     adenovirus for overexpression of FGF3
     stable overexpressing cell line services for FGF3
     inducible overexpressing cell line services for FGF3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FGF3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4