Aliases for FGF3 Gene
- Fibroblast Growth Factor 3 2 3 5
- Fibroblast Growth Factor 3 (Murine Mammary Tumor Virus Integration Site (V-Int-2) Oncogene Homolog) 2 3
- V-INT2 Murine Mammary Tumor Virus Integration Site Oncogene Homolog 2 3
- Murine Mammary Tumor Virus Integration Site 2, Mouse 2 3
- Heparin-Binding Growth Factor 3 3 4
- INT-2 Proto-Oncogene Protein 2 3
External Ids for FGF3 Gene
Previous HGNC Symbols for FGF3 Gene
Previous GeneCards Identifiers for FGF3 Gene
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]
FGF3 is a member of the basic fibroblast growth factor (FGF) gene family and was first identified based on it's similarity to the mouse proto-oncogene int-2. Amplifications of this gene and the surrounding region (11q13) have been observed in various cancers including breast cancer, esophogeal cancer, melanoma, bladder cancer and hepatocellular carcinoma (HCC). Lower tumor grade and stage have been associated with FGF3 amplifications in HCC; however, this event is fairly rare in this tumor type.
GeneCards Summary for FGF3 Gene
FGF3 (Fibroblast Growth Factor 3) is a Protein Coding gene. Diseases associated with FGF3 include Deafness, Congenital, With Inner Ear Agenesis, Microtia, And Microdontia and Deafness With Labyrinthine Aplasia Microtia And Microdontia. Among its related pathways are RET signaling and Negative regulation of FGFR3 signaling. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF10.
UniProtKB/Swiss-Prot for FGF3 Gene
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.