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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF22 Gene

protein-coding   GIFtS: 55
GCID: GC19P000639

Fibroblast Growth Factor 22

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibroblast Growth Factor 221 2
FGF-222 3

External Ids:    HGNC: 36791   Entrez Gene: 270062   Ensembl: ENSG000000703887   OMIM: 6058315   UniProtKB: Q9HCT03   

Export aliases for FGF22 gene to outside databases

Previous GC identifers: GC19P000691 GC19P000580 GC19P000590 GC19P000410


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FGF22 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities and are involved in a variety of biological processes
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse
homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle,
which suggested a role in hair development. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF22 Gene: 
FGF22 (fibroblast growth factor 22) is a protein-coding gene. Diseases associated with FGF22 include melanoma, and adenocarcinoma, and among its related super-pathways are Regulation of actin cytoskeleton and Rac1 Pathway. GO annotations related to this gene include growth factor activity. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF22_HUMAN, Q9HCT0
Function: Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell
proliferation (in vitro). May be involved in hair development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF22 gene promoter:
         Egr-1   MyoD   AP-2gamma   POU3F2   E47   HEN1   AP-2beta   SEF-1 (1)   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF22 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

FGF22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF22 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000639:  view genomic region     (about GC identifiers)

Start:
639,879 bp from pter      End:
643,703 bp from pter
Size:
3,825 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FGF22_HUMAN, Q9HCT0 (See protein sequence)
Recommended Name: Fibroblast growth factor 22 precursor  
Size: 170 amino acids; 19663 Da
Subunit: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1
Subcellular location: Secreted (Potential)
Secondary accessions: B2RPH4

Explore the universe of human proteins at neXtProt for FGF22: NX_Q9HCT0

Explore proteomics data for FGF22 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCT0

  • FGF22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FGF22 Protein Expression
    REFSEQ proteins: NP_065688.1  
    ENSEMBL proteins: 
     ENSP00000466004   ENSP00000215530   ENSP00000166133  
    Reactome Protein details: Q9HCT0
    Human Recombinant Protein Products for FGF22: 
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    OriGene Protein Over-expression Lysate for FGF22
    OriGene Custom MassSpec 
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    GenScript Custom Purified and Recombinant Proteins Services for FGF22
    Novus Biologicals FGF22 Proteins
    Novus Biologicals FGF22 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for FGF22
    Cloud-Clone Corp. Proteins for FGF22 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space NAS11342227
    GO:0005730nucleolus IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0009986cell surface IEA--

    FGF22 for ontologies           About GeneDecksing



    FGF22 Antibody Products: 
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    Novus Biologicals FGF22 Antibodies
    Abcam antibodies for FGF22
    Cloud-Clone Corp. Antibodies for FGF22 
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    LSBio Antibodies in human, mouse, rat for FGF22 

    Assay Products for FGF22: 
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    Cloud-Clone Corp. ELISAs for FGF22 
    Cloud-Clone Corp. CLIAs for FGF22


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry Q9HCT0

    ProtoNet protein and cluster: Q9HCT0

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF22_HUMAN, Q9HCT0
    Similarity: Belongs to the heparin-binding growth factors family


    FGF22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF22_HUMAN, Q9HCT0
    Function: Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell
    proliferation (in vitro). May be involved in hair development

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IEA--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
         
    FGF22 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FGF22:
     Decreased nuclei size in G2M 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fgf22):
     behavior/neurological  homeostasis/metabolism  integument  nervous system  tumorigenesis 

    FGF22 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FGF22: Fgf22tm1Rpgr Fgf22tm1Dgen

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FGF22 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FGF22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF22 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF22 

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    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FGF22

    Clone
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    GenScript: all cDNA clones in your preferred vector: FGF22 (NM_020637)
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                         Customized lentivirus expression plasmids for stable overexpression of FGF22 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF22


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FGF22 About   (see all 32)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    4PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI-3K cascade0.88
    Signaling by SCF-KIT0.72
    5IRS-related events
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events triggered by IGF1R0.93
    PI3K Cascade0.86
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.79

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF22 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for FGF22
        Regulation of Actin Cytoskeleton

    5/51        Reactome Pathways for FGF22 (see all 51)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction


    5/6         Kegg Pathways  (Kegg details for FGF22) (see all 6):
        MAPK signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Proteoglycans in cancer


    FGF22 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FGF22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for FGF22 (Q9HCT03 ENSP000002155304) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFBP1Q145123I2D: score=1 
    FGF1ENSP000003385484STRING: ENSP00000338548
    FGF10ENSP000002646644STRING: ENSP00000264664
    FGF3ENSP000003341224STRING: ENSP00000334122
    FGF6ENSP000002288374STRING: ENSP00000228837
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0030154cell differentiation NAS11342227
    GO:0038095Fc-epsilon receptor signaling pathway TAS--

    FGF22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF22

    Search CenterWatch for drugs/clinical trials and news about FGF22

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FGF22 gene: 
    NM_020637.1  

    Unigene Cluster for FGF22:

    Fibroblast growth factor 22
    Hs.248087  [show with all ESTs]
    Unigene Representative Sequence: BC041334
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591390 ENST00000586042 ENST00000215530(uc010xfq.2 uc010xfr.1)
    ENST00000166133
    miRNA
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                         Customized lentivirus expression plasmids for stable overexpression of FGF22 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF22

    Additional mRNA sequence: 

    AB021925.1 AY359084.1 BC041334.2 BC137444.1 BC137445.1 BC144645.1 

    2 DOTS entries:

    DT.91894997  DT.95073948 

    8 AceView cDNA sequences:

    NM_020637 AY359084 AB021925 BF058753 BI550620 BF507505 BC041334 BX279656 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF22 expression in normal human tissues (normalized intensities)      FGF22 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCTGGCGC
    FGF22 Expression
    About this image


    FGF22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells

    See FGF22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF22

    SOURCE GeneReport for Unigene cluster: Hs.248087
        SABiosciences Expression via Pathway-Focused PCR Array including FGF22: 
              Growth Factors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FGF22 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf221 , 5 fibroblast growth factor 221, 5 83.23(n)1
    85.71(a)1
      10 (39.72 cM)5
    671121  NM_023304.11  NP_075793.11 
     797551195 
    chicken
    (Gallus gallus)
    Aves LOC1008583381 fibroblast growth factor 22-like 71.01(n)
    62.73(a)
      100858338  XM_003642868.1  XP_003642916.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf226
    fgf226
    fibroblast growth factor 22
    42(a)
    42(a)
    1 ↔ many
    1 ↔ many
    22(19336981-19377255)
    22(19429773-19474661)


    ENSEMBL Gene Tree for FGF22 (if available)
    TreeFam Gene Tree for FGF22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF22 gene
    FGF122  FGF162  FGF52  FGF202  FGF42  FGF62  FGF92  FGF32  
    FGF72  FGF112  FGF102  FGF132  FGF142  
    16 SIMAP similar genes for FGF22 using alignment to 3 protein entries:     FGF22_HUMAN (see all proteins):
    FGF10    PRED3    FGF7    FGF16    KGFLP1    KGFLP2
    FGF9    FGF20    FGF12    FGF13    FGF5    FGF3
    FGF11    FGF2    FGF1    FGF4

    FGF22 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/240 SNPs in FGF22 are shown (see all 240)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104228511,2
    C,F,A--637929(+) ggaatC/Tttctg 1 -- us2k16Minor allele frequency- T:0.23WA CSA NA EA 364
    rs287170481,2
    --637948(+) CAGTCA/GTGGTG 1 -- us2k10--------
    rs1842719511,2
    --638174(+) GCTGAA/GGCAGG 1 -- us2k10--------
    rs1451106421,2
    C--638195(+) GAACCA/GGGGAG 1 -- us2k10--------
    rs1878658841,2
    --638236(+) ACTGCA/GCTCCA 1 -- us2k10--------
    rs1115201871,2
    C,F--638239(+) GCACTC/ACAGTC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1923824941,2
    --638268(+) TCCGTC/TTCAAA 1 -- us2k10--------
    rs1845318651,2
    --638398(+) CTCACC/TGCTGT 1 -- us2k10--------
    rs104083771,2
    C,F,H--638399(+) TCACCG/ACTGTG 1 -- us2k111Minor allele frequency- A:0.08NS NA WA 1750
    rs38148931,2
    C,F--638501(-) CTTCTC/TGCCAG 1 -- us2k12Minor allele frequency- T:0.06WA EA 238

    HapMap Linkage Disequilibrium report for FGF22 (639879 - 643703 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/38 variations for FGF22 (see all 38):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2176059CNV Deletion18987734
    esv2717757CNV Deletion23290073
    esv2740886CNV Deletion23290073
    esv1315871CNV Insertion17803354
    esv990334CNV Insertion20482838
    nsv910235CNV Loss21882294
    dgv3528n71CNV Loss21882294
    dgv3515n71CNV Loss21882294
    nsv910254CNV Loss21882294
    dgv3539n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): FGF22
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605831    OMIM disorders: --

    4 diseases for FGF22:    About MalaCards
    melanoma    adenocarcinoma    pancreatitis    breast cancer


    FGF22 for disorders           About GeneDecksing


    Export disorders for FGF22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF22 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with FGF22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 2, 3 Zhang X....Ornitz D.M. (2006)
    2. Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle. (PubMed id 11342227)1, 2, 9 Nakatake Y.... Itoh N. (2001)
    3. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PubMed id 15806171)1, 2 Beer H.-D....Werner S. (2005)
    4. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. (PubMed id 15260994)1, 3 Umemori H....Sanes J.R. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    7. Fibroblast growth factor signalling: from development to cancer. (PubMed id 20094046)2 Turner N. and Grose R. (2010)
    8. Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. (PubMed id 17133345)1 Moffa A.B. and Ethier S.P. (2007)
    9. Functional phylogeny relates LET-756 to fibroblast growth factor 9. (PubMed id 15199049)1 Popovici C....Roubin R. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27006 HGNC: 3679 AceView: FGF22 Ensembl:ENSG00000070388 euGenes: HUgn27006
    ECgene: FGF22 Kegg: 27006 H-InvDB: FGF22

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF22 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF22 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf22/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FGF22 gene:
    Search GeneIP for patents involving FGF22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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