Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FGF22 Gene

Aliases for FGF22 Gene

  • Fibroblast Growth Factor 22 2 3
  • FGF-22 3 4

External Ids for FGF22 Gene

Summaries for FGF22 Gene

Entrez Gene Summary for FGF22 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for FGF22 Gene

FGF22 (Fibroblast Growth Factor 22) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF4.

UniProtKB/Swiss-Prot for FGF22 Gene

  • Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF22 Gene

Genomics for FGF22 Gene

Genomic Location for FGF22 Gene

Start:
639,879 bp from pter
End:
643,824 bp from pter
Size:
3,946 bases
Orientation:
Plus strand

Genomic View for FGF22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF22 Gene

Regulatory Elements for FGF22 Gene

Proteins for FGF22 Gene

  • Protein details for FGF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCT0-FGF22_HUMAN
    Recommended name:
    Fibroblast growth factor 22
    Protein Accession:
    Q9HCT0
    Secondary Accessions:
    • B2RPH4

    Protein attributes for FGF22 Gene

    Size:
    170 amino acids
    Molecular mass:
    19663 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.

neXtProt entry for FGF22 Gene

Proteomics data for FGF22 Gene at MOPED

Post-translational modifications for FGF22 Gene

No Post-translational modifications

Other Protein References for FGF22 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF22 Gene

Domains for FGF22 Gene

UniProtKB/Swiss-Prot:

FGF22_HUMAN
Family:
  • Belongs to the heparin-binding growth factors family.:
    • Q9HCT0
genes like me logo Genes that share domains with FGF22: view

No data available for Gene Families for FGF22 Gene

Function for FGF22 Gene

Molecular function for FGF22 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.

Gene Ontology (GO) - Molecular Function for FGF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0005515 protein binding --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with FGF22: view
genes like me logo Genes that share phenotypes with FGF22: view

Animal Models for FGF22 Gene

MGI Knock Outs for FGF22:

miRNA for FGF22 Gene

miRTarBase miRNAs that target FGF22

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FGF22 Gene

Localization for FGF22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF22 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF22 Gene COMPARTMENTS Subcellular localization image for FGF22 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
mitochondrion 2
nucleus 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FGF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space NAS 11342227
GO:0005730 nucleolus IEA --
GO:0005794 Golgi apparatus IEA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with FGF22: view

Pathways for FGF22 Gene

SuperPathways for FGF22 Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 PI-3K cascade
3 Signaling by FGFR
4 FGFR ligand binding and activation
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF22: view

Interacting Proteins for FGF22 Gene

Gene Ontology (GO) - Biological Process for FGF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0030154 cell differentiation NAS 11342227
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FGF22: view

Transcripts for FGF22 Gene

mRNA/cDNA for FGF22 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF22 Gene

Fibroblast growth factor 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGF22 Gene

No ASD Table

Relevant External Links for FGF22 Gene

GeneLoc Exon Structure for
FGF22
ECgene alternative splicing isoforms for
FGF22

Expression for FGF22 Gene

mRNA expression in normal human tissues for FGF22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF22 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (8.5) and Skin - Sun Exposed (Lower leg) (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FGF22 Gene

SOURCE GeneReport for Unigene cluster for FGF22 Gene Hs.248087

genes like me logo Genes that share expressions with FGF22: view

Orthologs for FGF22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF22 37
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGF22 36
  • 81.41 (n)
  • 76.92 (a)
FGF22 37
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF22 36
  • 86.49 (n)
  • 79.08 (a)
FGF22 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf22 36
  • 81.38 (n)
  • 83.45 (a)
Fgf22 16
Fgf22 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGF22 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF22 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf22 36
  • 81.38 (n)
  • 83.45 (a)
chicken
(Gallus gallus)
Aves FGF22 36
  • 74.2 (n)
  • 67.12 (a)
FGF22 37
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fgf22 37
  • 43 (a)
OneToMany
fgf22 37
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 37
  • 19 (a)
OneToMany
Species with no ortholog for FGF22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF22 Gene

ENSEMBL:
Gene Tree for FGF22 (if available)
TreeFam:
Gene Tree for FGF22 (if available)

Paralogs for FGF22 Gene

Paralogs for FGF22 Gene

Selected SIMAP similar genes for FGF22 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FGF22: view

Variants for FGF22 Gene

Sequence variations from dbSNP and Humsavar for FGF22 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2301779 -- 643,185(+) GCAGC(A/G)GTGCT intron-variant
rs2301780 -- 643,386(+) GGGTG(A/G)GCCGG intron-variant
rs2301781 -- 643,742(+) GGAGC(C/T)CTCCA downstream-variant-500B, utr-variant-3-prime
rs3787002 -- 640,271(+) GTTTC(C/T)GTGGT intron-variant
rs3787003 -- 640,525(+) AGTCG(C/G)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF22 Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
nsv910102 CNV Loss 21882294
nsv910109 CNV Loss 21882294
nsv470101 CNV Loss 18288195
dgv3508n71 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3511n71 CNV Loss 21882294
dgv3512n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3514n71 CNV Gain 21882294
dgv3515n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
dgv3518n71 CNV Loss 21882294
dgv3519n71 CNV Gain+Loss 21882294
dgv3525n71 CNV Loss 21882294
dgv3526n71 CNV Loss 21882294
dgv3528n71 CNV Loss 21882294
dgv3530n71 CNV Gain 21882294
dgv3531n71 CNV Loss 21882294
nsv910224 CNV Loss 21882294
dgv3532n71 CNV Gain 21882294
dgv3533n71 CNV Gain+Loss 21882294
dgv3534n71 CNV Loss 21882294
nsv910235 CNV Loss 21882294
dgv3535n71 CNV Loss 21882294
dgv3536n71 CNV Gain 21882294
dgv3537n71 CNV Loss 21882294
nsv910246 CNV Gain+Loss 21882294
dgv3538n71 CNV Gain 21882294
dgv3539n71 CNV Loss 21882294
nsv910252 CNV Loss 21882294
esv2176059 CNV Deletion 18987734
esv2717757 CNV Deletion 23290073
esv2740886 CNV Deletion 23290073
nsv910253 CNV Loss 21882294
nsv910254 CNV Loss 21882294
esv990334 CNV Insertion 20482838
esv1315871 CNV Insertion 17803354

Relevant External Links for FGF22 Gene

HapMap Linkage Disequilibrium report
FGF22
Human Gene Mutation Database (HGMD)
FGF22

Disorders for FGF22 Gene

No disorders were found for FGF22 Gene.

No data available for UniProtKB/Swiss-Prot for FGF22 Gene

Publications for FGF22 Gene

  1. Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle. (PMID: 11342227) Nakatake Y. … Itoh N. (Biochim. Biophys. Acta 2001) 3 4 23
  2. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PMID: 16597617) Zhang X. … Ornitz D.M. (J. Biol. Chem. 2006) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. (PMID: 15260994) Umemori H. … Sanes J.R. (Cell 2004) 2 3
  5. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PMID: 15806171) Beer H.-D. … Werner S. (Oncogene 2005) 3 4

Products for FGF22 Gene

Sources for FGF22 Gene

Back to Top

Content