FGF22 Gene
protein-coding GIFtS: 54
GCID: GC19P000639
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fibroblast growth factor 22
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Aliases
for FGF22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibroblast Growth Factor 221 2 | | FGF-222 3 |
Export aliases for FGF22 gene to outside databasesPrevious GC identifers: GC19P000691 GC19P000580 GC19P000590 GC19P000410 |
Summaries
for FGF22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FGF22:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possessbroad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonicdevelopment, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene wasfound to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hairdevelopment. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FGF22_HUMAN, Q9HCT0Function: Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cellproliferation (in vitro). May be involved in hair development
|
Genomic Views
for FGF22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FGF22 gene promoter:
Egr-1 MyoD AP-2gamma POU3F2 E47 HEN1 AP-2beta SEF-1 (1) AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for FGF22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3FGF22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P000639: view genomic region
(about GC identifiers)
Start:
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639,588 bp from pter |
End:
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643,703 bp from pter |
Size:
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4,116 bases |
Orientation:
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plus strand |
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Proteins
for FGF22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FGF22_HUMAN, Q9HCT0 (See
protein sequence)Recommended Name: Fibroblast growth factor 22 precursor Size: 170 amino acids; 19663 Da
Subunit: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1
Subcellular location: Secreted (Potential)
Secondary accessions: B2RPH4Explore the universe of human proteins at neXtProt for FGF22: NX_Q9HCT0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HCT0
FGF22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065688.1
ENSEMBL proteins: ENSP00000466004 ENSP00000215530 ENSP00000166133 Reactome Protein details: Q9HCT0
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
FGF22 for ontologies About GeneDecksing
FGF22 Antibody Products:
Assay Products for FGF22: |
Protein
Domains /
Families
for FGF22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FGF22 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HCT0ProtoNet protein and cluster: Q9HCT0 2 Blocks protein families: IPB002209 Heparin binding growth factor family signature IPB002348 IL1/HBGF family signature
UniProtKB/Swiss-Prot: FGF22_HUMAN, Q9HCT0Similarity: Belongs to the heparin-binding growth factors family |
Function
for FGF22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FGF22_HUMAN, Q9HCT0Function: Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cellproliferation (in vitro). May be involved in hair development
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF22
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0008083 | growth factor activity |
IEA | -- |
FGF22 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FGF22:
Animal Models:
Mouse knock-outs for FGF22: Fgf22tm1Rpgr Fgf22tm1Dgen
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Fgf22):
FGF22 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FGF22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts | | | 2 | Signaling by FGFR | | | 3 | PIP3 activates AKT signaling | | | 4 | IRS-related events | | | 5 | GPCR Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF22 (see all 59)
1  BioSystems Pathway for FGF22
5/50 
Reactome Pathways for FGF22 (see all 50)
4 
Kegg Pathways (Kegg details for FGF22):
FGF22 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FGF22
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/17 Interacting proteins for FGF22 (Q9HCT03 ENSP000002155304) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008286 | insulin receptor signaling pathway |
TAS | -- | | GO:0008543 | fibroblast growth factor receptor signaling pathway |
TAS | -- | | GO:0030154 | cell differentiation |
NAS | 11342227 |
FGF22 for ontologies About GeneDecksing
|
Drugs & Compounds
for FGF22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FGF22
Search CenterWatch for drugs/clinical trials and news about FGF22
|
Transcripts
for FGF22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FGF22 gene: NM_020637.1 Unigene Cluster for FGF22: Fibroblast growth factor 22 Hs.248087 [show with all ESTs]Unigene Representative Sequence: BC0413344 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000586042 ENST00000591390 ENST00000215530(uc010xfq.2 uc010xfr.1)
ENST00000166133
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF22 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF22
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FGF22 (NM_020637) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FGF22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF22 |
Additional cDNA sequence: AB021925.1 AY359084.1 BC041334.2 BC137444.1 BC137445.1 BC144645.1 2 DOTS entries: DT.91894997 DT.95073948 8 AceView cDNA sequences: AY359084 NM_020637 AB021925 BC041334 BF507505 BF058753 BI550620 BX279656
GeneLoc Exon Structure
|
Expression
for FGF22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FGF22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCTGGCGC
About this image
See FGF22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FGF22
SOURCE GeneReport for Unigene cluster: Hs.248087
SABiosciences Expression via Pathway-Focused PCR Array including FGF22:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FGF22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF22 |
Orthologs
for FGF22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FGF22 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for FGF22 (if available)
TreeFam Gene Tree for FGF22 (if available) |
Paralogs
for FGF22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FGF22 gene
- FGF122 FGF52 FGF202 FGF162 FGF42 FGF92 FGF62 FGF32
- FGF72 FGF112 FGF102 FGF132 FGF142
16 SIMAP similar genes for FGF22 using alignment to 3 protein entries: FGF22_HUMAN (see all proteins):FGF10 PRED3 FGF7 FGF16 KGFLP1 KGFLP2
FGF9 FGF20 FGF12 FGF13 FGF5 FGF3
FGF11 FGF2 FGF1 FGF4
FGF22 for paralogs About GeneDecksing
|
Genomic Variants
for FGF22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FGF22 (639588 - 643703 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for FGF22
4 CNVs: 30052 30050 30051 30053
1 Indel: 45794
Human Gene Mutation Database (HGMD): FGF22
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF22 |
|
Disorders
/ Diseases
for FGF22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FGF22 for disorders About GeneDecksing
OMIM gene information: 605831
OMIM disorders: --
5  diseases for FGF22: About MalaCardsgenetic disease melanoma breast cancer adenocarcinoma
pancreatitis
Export disorders for FGF22 gene to outside databases
|
Publications
for FGF22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FGF22 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with FGF22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PubMed id 16597617)1, 2, 3 Zhang X....Ornitz D.M. (2006)
- Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle. (PubMed id 11342227)1, 2, 9 Nakatake Y.... Itoh N. (2001)
- The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PubMed id 15806171)1, 2 Beer H.-D....Werner S. (2005)
- FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. (PubMed id 15260994)1, 3 Umemori H....Sanes J.R. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Fibroblast growth factor signalling: from development to cancer. (PubMed id 20094046)2 Turner N. and Grose R. (2010)
- Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. (PubMed id 17133345)1 Moffa A.B. and Ethier S.P. (2007)
- Functional phylogeny relates LET-756 to fibroblast growth factor 9. (PubMed id 15199049)1 Popovici C....Roubin R. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for FGF22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FGF22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FGF22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FGF22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FGF22 gene:
Search GeneIP for patents involving FGF22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FGF22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FGF22 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF22 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF22 | | | OriGene Protein Over-expression Lysate for FGF22 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FGF22 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF22 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF22 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FGF22 | | OriGene Custom Protein Services for FGF22 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FGF22 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF22 |
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| | | | Search Tocris compounds for FGF22 |
| |  |  |  |  | | | | | | Recombinant Protein for FGF22 |
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 | | | FGF22 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for FGF22 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF22 |
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