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Aliases for FGF22 Gene

Aliases for FGF22 Gene

  • Fibroblast Growth Factor 22 2 3 5
  • FGF-22 3 4

External Ids for FGF22 Gene

Previous GeneCards Identifiers for FGF22 Gene

  • GC19P000691
  • GC19P000580
  • GC19P000590
  • GC19P000410

Summaries for FGF22 Gene

Entrez Gene Summary for FGF22 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for FGF22 Gene

FGF22 (Fibroblast Growth Factor 22) is a Protein Coding gene. Among its related pathways are RET signaling and p70S6K Signaling. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF10.

UniProtKB/Swiss-Prot for FGF22 Gene

  • Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.

Additional gene information for FGF22 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF22 Gene

Genomics for FGF22 Gene

Regulatory Elements for FGF22 Gene

Enhancers for FGF22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H000718 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +79.8 79816 3.1 ELF3 ARID4B BMI1 DNMT3B THRB RARA EGR1 SCRT2 ZNF143 THAP11 HCN2 PALM FGF22 SHC2 C2CD4C GC19M000724
GH19H001382 1.5 ENCODE dbSUPER 10.8 +744.1 744147 2.2 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 SF3A2 CIRBP TMEM259 DAZAP1 MUM1 TCF3 LOC100288123 GRIN3B PTBP1 SPPL2B
GH19H001437 1.4 ENCODE dbSUPER 10.8 +799.6 799605 4.3 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 SSRP1 ZNF610 SF3A2 TCF3 TMEM259 LOC100288123 PTBP1 DAZAP1 MED16 GRIN3B ENSG00000267317 MUM1
GH19H000566 1.2 Ensembl ENCODE 12.3 -72.7 -72679 2.4 PKNOX1 ARID4B TCF12 CBX5 GATA2 ELK1 ATF7 SP5 REST NFIL3 LOC105372233 POLRMT FGF22 BSG PIR53036
GH19H000485 1.4 FANTOM5 Ensembl ENCODE 9.5 -154.0 -154020 1.3 ELF3 SOX13 TBP DRAP1 TFAP4 MXI1 ZNF792 SAP130 MLX ARID4B SHC2 FGF22 HCN2 MADCAM1 PALM C2CD4C ODF3L2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGF22 on UCSC Golden Path with GeneCards custom track

Promoters for FGF22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for FGF22 Gene

Genomic Locations for FGF22 Gene
4,493 bases
Plus strand

Genomic View for FGF22 Gene

Genes around FGF22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF22 Gene

Proteins for FGF22 Gene

  • Protein details for FGF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibroblast growth factor 22
    Protein Accession:
    Secondary Accessions:
    • B2RPH4

    Protein attributes for FGF22 Gene

    170 amino acids
    Molecular mass:
    19663 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.

neXtProt entry for FGF22 Gene

Post-translational modifications for FGF22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF22 Gene

Domains & Families for FGF22 Gene

Gene Families for FGF22 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FGF22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heparin-binding growth factors family.
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF22: view

Function for FGF22 Gene

Molecular function for FGF22 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.

Gene Ontology (GO) - Molecular Function for FGF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0008083 growth factor activity IEA --
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS --
genes like me logo Genes that share ontologies with FGF22: view
genes like me logo Genes that share phenotypes with FGF22: view

Animal Models for FGF22 Gene

MGI Knock Outs for FGF22:

miRNA for FGF22 Gene

miRTarBase miRNAs that target FGF22

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF22 Gene

Localization for FGF22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF22 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF22 gene
Compartment Confidence
extracellular 5
mitochondrion 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FGF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space NAS 11342227
GO:0005622 intracellular IEA --
GO:0005730 nucleolus IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with FGF22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF22 Gene

Pathways & Interactions for FGF22 Gene

SuperPathways for FGF22 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 Downstream signaling of activated FGFR2
4 GPCR Pathway
5 PI3K/AKT activation
genes like me logo Genes that share pathways with FGF22: view

Gene Ontology (GO) - Biological Process for FGF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0030154 cell differentiation NAS 11342227
genes like me logo Genes that share ontologies with FGF22: view

No data available for SIGNOR curated interactions for FGF22 Gene

Drugs & Compounds for FGF22 Gene

No Compound Related Data Available

Transcripts for FGF22 Gene

mRNA/cDNA for FGF22 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF22 Gene

Fibroblast growth factor 22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF22 Gene

No ASD Table

Relevant External Links for FGF22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGF22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF22 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x8.5) and Skin - Sun Exposed (Lower leg) (x7.4).

Protein differential expression in normal tissues from HIPED for FGF22 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF22 Gene

Protein tissue co-expression partners for FGF22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FGF22 Gene:


SOURCE GeneReport for Unigene cluster for FGF22 Gene:


Evidence on tissue expression from TISSUES for FGF22 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FGF22: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF22 Gene

Orthologs for FGF22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF22 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FGF22 34 33
  • 86.49 (n)
(Bos Taurus)
Mammalia FGF22 34 33
  • 81.41 (n)
(Mus musculus)
Mammalia Fgf22 34 16 33
  • 81.38 (n)
(Rattus norvegicus)
Mammalia Fgf22 33
  • 81.38 (n)
(Pan troglodytes)
Mammalia FGF22 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia FGF22 34
  • 68 (a)
(Monodelphis domestica)
Mammalia FGF22 34
  • 60 (a)
(Gallus gallus)
Aves FGF22 34 33
  • 74.2 (n)
(Danio rerio)
Actinopterygii fgf22 34 34
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 34
  • 19 (a)
Species where no ortholog for FGF22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF22 Gene

Gene Tree for FGF22 (if available)
Gene Tree for FGF22 (if available)

Paralogs for FGF22 Gene

Paralogs for FGF22 Gene

(16) SIMAP similar genes for FGF22 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FGF22: view

Variants for FGF22 Gene

Sequence variations from dbSNP and Humsavar for FGF22 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000370286 -- 638,263(+) AGACT(-/C)CCGTC upstream-variant-2KB
rs1000477211 -- 639,031(+) ACTGT(G/T)CTCAC upstream-variant-2KB
rs1000513711 -- 642,015(+) CAGGC(C/T)TCAAC intron-variant
rs1000672869 -- 638,252(+) GGTGA(C/T)AGAGC upstream-variant-2KB
rs1000826064 -- 641,266(+) GGGCG(C/T)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF22 Gene

Variant ID Type Subtype PubMed ID
nsv953938 CNV deletion 24416366
nsv578163 CNV loss 21841781
nsv577978 CNV gain 21841781
nsv470101 CNV loss 18288195
nsv428360 CNV gain 18775914
esv990334 CNV insertion 20482838
esv3643358 CNV gain 21293372
esv3643357 CNV loss 21293372
esv3425099 CNV insertion 20981092
esv2740886 CNV deletion 23290073
esv2717757 CNV deletion 23290073
esv2176059 CNV deletion 18987734
esv1315871 CNV insertion 17803354
dgv134n111 CNV deletion 26073780

Variation tolerance for FGF22 Gene

Gene Damage Index Score: 2.92; 48.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF22 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF22 Gene

Disorders for FGF22 Gene

Relevant External Links for FGF22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FGF22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGF22 Gene

Publications for FGF22 Gene

  1. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PMID: 16597617) Zhang X … Ornitz DM (The Journal of biological chemistry 2006) 2 3 4 60
  2. Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle. (PMID: 11342227) Nakatake Y … Itoh N (Biochimica et biophysica acta 2001) 3 4 22 60
  3. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PMID: 15806171) Beer HD … Werner S (Oncogene 2005) 3 4 60
  4. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. (PMID: 15260994) Umemori H … Sanes JR (Cell 2004) 2 3 60
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60

Products for FGF22 Gene

Sources for FGF22 Gene

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