External Ids for FGF21 Gene
Previous GeneCards Identifiers for FGF21 Gene
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGF21 Gene
FGF21 (Fibroblast Growth Factor 21) is a Protein Coding gene. Diseases associated with FGF21 include diabetes mellitus, noninsulin-dependent. Among its related pathways are PI3K-Akt signaling pathway and MAPK signaling pathway. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF23.
UniProtKB/Swiss-Prot for FGF21 Gene
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.