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FGF21 Gene

protein-coding   GIFtS: 60
GCID: GC19P049259

Fibroblast Growth Factor 21

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 211 2
FGF-213

External Ids:    HGNC: 36781   Entrez Gene: 262912   Ensembl: ENSG000001055507   OMIM: 6094365   UniProtKB: Q9NSA13   

Export aliases for FGF21 gene to outside databases

Previous GC identifers: GC19P049818 GC19P049626 GC19P053934 GC19P053950 GC19P053951 GC19P045638


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF21 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members
possess broad mitogenic and cell survival activities and are involved in a variety of biological processes
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The
function of this growth factor has not yet been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF21 Gene:
FGF21 (fibroblast growth factor 21) is a protein-coding gene. Diseases associated with FGF21 include fatty liver disease, and anorexia nervosa. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF19.

UniProtKB/Swiss-Prot: FGF21_HUMAN, Q9NSA1
Function: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter
SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB

Gene Wiki entry for FGF21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF21 gene promoter:
         PPAR-gamma1   p300   MyoD   STAT3   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF21 promoter sequence
   Search Chromatin IP Primers for FGF21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

FGF21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF21 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049259:  view genomic region     (about GC identifiers)

Start:
49,258,816 bp from pter      End:
49,261,587 bp from pter
Size:
2,772 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FGF21_HUMAN, Q9NSA1 (See protein sequence)
Recommended Name: Fibroblast growth factor 21 precursor  
Size: 209 amino acids; 22300 Da
Subunit: Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4
Secondary accessions: Q8N683

Explore the universe of human proteins at neXtProt for FGF21: NX_Q9NSA1

Explore proteomics data for FGF21 at MOPED


See FGF21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_061986.1  
ENSEMBL proteins: 
 ENSP00000471477   ENSP00000222157  

FGF21 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for FGF21

FGF21 Antibody Products:

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Abcam antibodies for FGF21
Cloud-Clone Corp. Antibodies for FGF21
ThermoFisher Antibody for FGF21
LSBio Antibodies in human, mouse, rat for FGF21

FGF21 Assay Products:

Browse Kits and Assays available from EMD Millipore
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R&D Systems ELISAs for FGF21 (FGF-21)         (see all)
GenScript Custom Assay Services for FGF21
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for FGF21
Cloud-Clone Corp. CLIAs for FGF21


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR028142 IL-1_fam/FGF_fam
 IPR008996 Cytokine_IL1-like
 IPR002209 Fibroblast_GF_fam
 IPR028292 FGF21

Graphical View of Domain Structure for InterPro Entry Q9NSA1

ProtoNet protein and cluster: Q9NSA1

2 Blocks protein domains:
IPB002209 Heparin binding growth factor family signature
IPB002348 IL1/HBGF family signature


UniProtKB/Swiss-Prot: FGF21_HUMAN, Q9NSA1
Similarity: Belongs to the heparin-binding growth factors family


FGF21 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FGF21_HUMAN, Q9NSA1
Function: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter
SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005104fibroblast growth factor receptor binding ----
GO:0005515protein binding IPI18829467
GO:0008083growth factor activity IEA--
     
FGF21 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for FGF21:
 Increased cell death HMECs cel 

     10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Fgf21):
 adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  limbs/digits/tail 
 liver/biliary system  nervous system  no phenotypic analysis  normal  skeleton 

FGF21 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for FGF21: Fgf21tm1Fdl Fgf21tm1.1Djm Fgf21tm1Emf

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF21
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF21

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF21
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF21

miRNA
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1 qRT-PCR Assays for microRNA that regulate FGF21:
hsa-miR-577
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for FGF21
Predesigned siRNA for gene silencing in human, mouse, rat FGF21

Gene Editing
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Clone
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OriGene clones in human, mouse for FGF21 (see all 5)
OriGene ORF clones in mouse, rat for FGF21
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FGF21 (NM_019113)
Sino Biological Human cDNA Clone for FGF21
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF21
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF21

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF21


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FGF21_HUMAN, Q9NSA1: Secreted (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular4
cytosol1
mitochondrion1
nucleus1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

FGF21 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for FGF21 About   (see all 22)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Regulation of actin cytoskeleton
Regulation of actin cytoskeleton0.57
Regulation of Actin Cytoskeleton0.57
2Apoptotic Pathways in Synovial Fibroblasts
Mitochondrial Apoptosis0.85
Rac1 Pathway0.65
Cellular Apoptosis Pathway0.85
Glioma Invasiveness0.64
Apoptotic Pathways in Synovial Fibroblasts0.84
Actin-Based Motility by Rho Family GTPases0.62
p53 Mediated Apoptosis0.84
ERK5 Signaling0.61
3GPCR Pathway
Ras Pathway0.73
Breast Cancer Regulation by Stathmin10.58
Paxillin Interactions0.73
NFAT in Immune Response0.58
GPCR Pathway0.62
Estrogen Pathway0.55
Pancreatic Adenocarcinoma0.59
P2Y Receptor Signaling0.38
4TGF-Beta Pathway
TGF-Beta Pathway0.60
JNK Pathway0.51
MAPK Family Pathway0.60
Regulation of eIF4 and p70S6K0.43
JAK-STAT Pathway0.57
SOCS Pathway0.40
5ERK Signaling
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
ILK Signaling0.49
MAPK Signaling0.58

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF21 (see all 59)
    Nuclear Receptor Activation by Vitamin-A
Paxillin Interactions
Telomerase Components in Cell Signaling
Mitochondrial Apoptosis
Molecular Mechanisms of Cancer

2 BioSystems Pathways for FGF21
    SREBP signalling
Regulation of Actin Cytoskeleton



Selected Kegg Pathways  (Kegg details for FGF21) (see all 8):
    MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton


FGF21 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FGF21
Interactions:

    Search GeneGlobe Interaction Network for FGF21

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for FGF21 (Q9NSA11, 2, 3 ENSP000002221574) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
InteractantInteraction Details
GeneCardExternal ID(s)
KLBQ86Z141, 2, 3, ENSP000002574084EBI-3909329,EBI-8515198 MINT-6799907 MINT-6799922 I2D: score=2 STRING: ENSP00000257408
EGFRENSP000002754934STRING: ENSP00000275493
FGFR1ENSP000003802804STRING: ENSP00000380280
FGFR2ENSP000004102944STRING: ENSP00000410294
FGFR3ENSP000002607954STRING: ENSP00000260795
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007165signal transduction TAS10858549
GO:0007267cell-cell signaling TAS10858549
GO:0008284positive regulation of cell proliferation IEA--
GO:0010988regulation of low-density lipoprotein particle clearance NAS--
GO:0045716positive regulation of low-density lipoprotein particle receptor biosynthetic process NAS--

FGF21 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FGF21

2 Novoseek inferred chemical compound relationships for FGF21 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glucose 36.8 6 19487637 (2), 19699495 (2), 18187602 (1), 17063460 (1) (see all 8)
lipid 32.3 7 19318452 (2), 19699495 (2), 19401423 (1), 20332535 (1) (see all 6)



FGF21 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for FGF21 gene: 
NM_019113.2  

Unigene Cluster for FGF21:

Fibroblast growth factor 21
Hs.283015  [show with all ESTs]
Unigene Representative Sequence: BC018404
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000593756 ENST00000222157(uc002pkn.1 uc002pko.1)
miRNA
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1 qRT-PCR Assays for microRNA that regulate FGF21:
hsa-miR-577
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for FGF21
Predesigned siRNA for gene silencing in human, mouse, rat FGF21
Clone
Products:
     
OriGene clones in human, mouse for FGF21 (see all 5)
OriGene ORF clones in mouse, rat for FGF21
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FGF21 (NM_019113)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF21
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF21
Primer
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OriGene qPCR primer pairs and template standards for FGF21
OriGene qSTAR qPCR primer pairs in human, mouse for FGF21
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FGF21
  QuantiTect SYBR Green Assays in human, mouse, rat FGF21
  QuantiFast Probe-based Assays in human, mouse, rat FGF21

Additional mRNA sequence: 

AB021975.1 AY359086.1 BC018404.1 

1 DOTS entry:

DT.92037354 

4 AceView cDNA sequences:

NM_019113 AB021975 BC018404 AY359086 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FGF21 expression in normal human tissues (normalized intensities)      FGF21 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGGGACCTT
FGF21 Expression
About this image


FGF21 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Eye (Sensory Organs)
         Retina
FGF21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FGF21 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.283015
    Custom PCR Arrays for FGF21
Primer
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OriGene qPCR primer pairs and template standards for FGF21
OriGene qSTAR qPCR primer pairs in human, mouse for FGF21
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QuantiFast Probe-based Assays in human, mouse, rat FGF21
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF21

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FGF21 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fgf211 , 5 fibroblast growth factor 211, 5 80.13(n)1
79.29(a)1
  7 (29.38 cM)5
566361  NM_020013.41  NP_064397.11 
 456139075 
lizard
(Anolis carolinensis)
Reptilia FGF216
fibroblast growth factor 21
38(a)
1 ↔ 1
GL343355.1(839719-843782)
zebrafish
(Danio rerio)
Actinopterygii fgf216
fibroblast growth factor 21
31(a)
1 ↔ 1
3(27132119-27136449) ENSDARG00000070492


ENSEMBL Gene Tree for FGF21 (if available)
TreeFam Gene Tree for FGF21 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FGF21 gene
FGF192  FGF232  
1 SIMAP similar gene for FGF21 using alignment to 1 protein entry:     FGF21_HUMAN:
FGF19

FGF21 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FGF21 (see all 67)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs116698021,2
H--49260835(+) tggacC/Tcctgg 1 -- int10--------
rs116736301,2
C,H--49260871(+) ctggaA/Cccctg 1 -- int10--------
rs1136148201,2
C,F--49260872(+) TGGACC/TCCTGG 1 -- int11Minor allele frequency- T:0.50CSA 2
rs116698071,2
C,H--49260875(+) accccC/Tgggtc 1 -- int10--------
rs116736901,2
C,H--49260892(+) aggagA/Gggctg 1 -- int1 trp30--------
rs104264451,2
A--49260907(+) ctggaA/Cccccg 1 -- int10--------
rs104267781,2
A--49260911(+) aacccC/Tgggtc 1 -- int10--------
rs104266061,2
C,A--49260928(+) aggagA/Gggctg 1 -- int1 trp30--------
rs99171181,2
C--49260964(+) aggagA/Gggctg 1 -- int1 trp30--------
rs16882631,2
C,F,A--49261038(+) GGAGAA/GACTAG 1 -- int1 trp310Minor allele frequency- G:0.30NS NA CSA WA EA 536

HapMap Linkage Disequilibrium report for FGF21 (49258816 - 49261587 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for FGF21:    About this table    
Variant IDTypeSubtypePubMed ID
esv2718688CNV Deletion23290073
esv2718687CNV Deletion23290073
esv2718689CNV Deletion23290073
esv2718686CNV Deletion23290073
nsv833855CNV Loss17160897
dgv3967n71CNV Loss21882294
dgv3968n71CNV Loss21882294
nsv912244CNV Gain21882294
nsv9739CNV Gain+Loss18304495

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FGF21
DNA2.0 Custom Variant and Variant Library Synthesis for FGF21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609436    OMIM disorders: --

Selected diseases for FGF21 (see all 22):    About MalaCards
fatty liver disease    anorexia nervosa    cushing's syndrome    liver disease
lipodystrophy    diabetic nephropathy    gestational diabetes    acute pancreatitis
kidney disease    insulin resistance    coronary heart disease    obesity
diabetes mellitus    bipolar disorder    retinitis    melanoma
rheumatoid arthritis    arthritis    adenocarcinoma    pancreatitis

2 diseases from the University of Copenhagen DISEASES database for FGF21:
Diabetes mellitus     Fatty liver disease

FGF21 for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for FGF21 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
niddm 16.1 1 19528204 (1), 18460341 (1)

Genetic Association Database (GAD): FGF21
Human Genome Epidemiology (HuGE) Navigator: FGF21 (1 document)

Export disorders for FGF21 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FGF21 gene, integrated from 10 sources (see all 117):
(articles sorted by number of sources associating them with FGF21)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. (PubMed id 10858549)1, 2, 3 Nishimura T.... Itoh N. (Biochim. Biophys. Acta 2000)
  2. Different roles of N- and C- termini in the functional activity of FGF21. (PubMed id 19117008)1, 2, 9 Micanovic R.... Kharitonenkov A. (J. Cell. Physiol. 2009)
  3. FGF21 signalling pathway and metabolic traits - genetic association analysis. (PubMed id 20717167)1, 4 Kaess B.M....Tomaszewski M. (Eur. J. Hum. Genet. 2010)
  4. C-terminal tail of FGF19 determines its specificity toward Klotho co- receptors. (PubMed id 18829467)1, 2 Wu X.... Li Y. (J. Biol. Chem. 2008)
  5. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. (PubMed id 17623664)1, 2 Kurosu H....Kuro-o M. (J. Biol. Chem. 2007)
  6. FGF-21 as a novel metabolic regulator. (PubMed id 15902306)1, 2 Kharitonenkov A.... Shanafelt A.B. (J. Clin. Invest. 2005)
  7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
  8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  9. Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia. (PubMed id 19699495)1, 9 Stein S....Fasshauer M. (Metab. Clin. Exp. 2010)
  10. Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa. (PubMed id 19926712)1, 9 Fazeli P.K....Klibanski A. (J. Clin. Endocrinol. Metab. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26291 HGNC: 3678 AceView: FGF21 Ensembl:ENSG00000105550 euGenes: HUgn26291
ECgene: FGF21 Kegg: 26291 H-InvDB: FGF21

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FGF21 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FGF21 Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf21/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FGF21 gene:
Search GeneIP for patents involving FGF21

GeneCards and IP:
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