FGF21 Gene

Aliases
for FGF21 gene

Previous GC identifers: GC19P049818 GC19P049626 GC19P053934 GC19P053950 GC19P053951 GC19P045638

Summaries
for FGF21 gene

Genomic Views
for FGF21 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: FGF21 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF21

FGF21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049259:  view genomic region     (about GC identifiers)

Proteins
for FGF21 gene

Explore the universe of human proteins at neXtProt for FGF21: NX_Q9NSA1

FGF21 Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for FGF21 (FGF-21)
	Enzo Life Sciences proteins for FGF21
	OriGene Purified Protein: FGF21 OriGene Protein Over-expression Lysate: FGF21 OriGene Custom Protein Services for FGF21
	GenScript Purified and Recombinant Proteins for FGF21
	Novus Biologicals FGF21 Proteins Novus Biologicals FGF21 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for FGF21
	Uscn Proteins for FGF21

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for FGF21 (FGF-21)
	OriGene Antibodies (see all 15): FGF21 OriGene Custom Antibody Services for FGF21
	GenScript Custom Superior Antibodies Services for FGF21
	Novus Biologicals FGF21 Antibodies
	Abcam antibodies for FGF21
	Uscn Antibodies for FGF21
	ThermoFisher Antibodies for FGF21

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for FGF21 (FGF-21)         (see all)
	GenScript Custom Assay Services for FGF21
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FGF21

Protein Domains /
Families
for FGF21 gene

ProtoNet protein and cluster: Q9NSA1

Function
for FGF21 gene

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 5 alleles) (MGI details for Fgf21)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FGF21

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF21
		1 QIAGEN miScript miRNA Assays for microRNA that regulate FGF21:
		hsa-miR-577
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF21 (see all 7) OriGene shRNA RFP: FGF21 OriGene siRNA: FGF21
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF21
		Sirion Biotech Custom design and validation of potent shRNA sequences against FGF21

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for FGF21
			Sirion Biotech Customized adenovirus for overexpression of FGF21  Sirion Biotech Customized adenovirus for potent knockdown of FGF21

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF21 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF21 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FGF21 (NM_019113)
		Sino Biological Human cDNA Clone for FGF21
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF21

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FGF21
		Search LifeMap BioReagents cell lines for FGF21
		Sirion Biotech Customized stable knockdown cell line services for FGF21  Sirion Biotech Customized inducible knockdown cell line services for FGF21 Sirion Biotech Customized stable overexpressing cell line services for FGF21 Sirion Biotech Customized inducible overexpressing cell line services for FGF21

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FGF21

Pathways & Interactions
for FGF21 gene

	Super-pathway	contained gene-specific pathways
1	Apoptotic Pathways in Synovial Fibroblasts	8/14 pathways (see all 14) Apoptotic Pathways in Synovial Fibroblasts 1.00 ERK5 Signaling 0.61 p53 Mediated Apoptosis 0.84 eIF2 Pathway 0.60 Mitochondrial Apoptosis 0.73 Rac1 Pathway 0.58 Telomerase Components in Cell Signaling 0.72 Nuclear Receptor Activation by Vitamin-A 0.57
2	GPCR Pathway	GPCR Pathway 1.00 Estrogen Pathway 0.55 Ras Pathway 0.62 Pancreatic Adenocarcinoma 0.55 Breast Cancer Regulation by Stathmin1 0.58 Paxillin Interactions 0.53 NFAT in Immune Response 0.58 P2Y Receptor Signaling 0.38
3	TGF-Beta Pathway	TGF-Beta Pathway 1.00 JNK Pathway 0.50 MAPK Family Pathway 0.60 Regulation of eIF4 and p70S6K 0.43 JAK-STAT Pathway 0.57 SOCS Pathway 0.29
4	Rho Family GTPases	Rho Family GTPases 1.00 MAPK Signaling 0.51 ERK Signaling 0.61 ILK Signaling 0.45 Molecular Mechanisms of Cancer 0.51
5	Nanog in Mammalian ESC Pluripotency	Nanog in Mammalian ESC Pluripotency 1.00 14-3-3 Induced Intracellular Signaling 0.59 GSK3 Signaling 0.61 eNOS Signaling 0.48

5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF21

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 BioSystems Pathway for FGF21

Regulation of Actin Cytoskeleton

4         Kegg Pathways  (Kegg details for FGF21)

	MAPK signaling pathway
	Regulation of actin cytoskeleton
	Pathways in cancer
	Melanoma

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

Drugs & Compounds
for FGF21 gene

Transcripts
for FGF21 gene

Expression
for FGF21 gene

FGF21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGGACCTT

About this image

FGF21 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)			Cartilage
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FGF21 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FGF21
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FGF21
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF21

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FGF21

Orthologs
for FGF21 gene

Paralogs
for FGF21 gene

Paralogs for FGF21 gene

FGF19²  FGF23²  

1 SIMAP similar gene for FGF21 using alignment to 1 protein entry:     FGF21_HUMAN:

FGF19

FGF21 for paralogs           About GeneDecksing

Genomic Variants
for FGF21 gene

10/57 NCBI SNPs in FGF21 are shown (see all 57)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs8381311,2	C,F,A,H	--	49260677(-)	CGGGGT/GGTCTC	1	--	int1		14		EA NA MN WA CSA	690
rs116698021,2	H	--	49260835(+)	tggacC/Tcctgg	1	--	int1		0	--	--	--	--
rs116736301,2	C,H	--	49260871(+)	ctggaA/Cccctg	1	--	int1		0	--	--	--	--
rs1136148201,2		--	49260872(+)	TGGACC/TCCTGG	1	--	int1		1		CSA	2
rs116698071,2	H	--	49260875(+)	accccC/Tgggtc	1	--	int1		0	--	--	--	--
rs116736901,2	H	--	49260892(+)	aggagA/Gggctg	1	--	int1 trp3		0	--	--	--	--
rs104264451,2	A	--	49260907(+)	ctggaA/Cccccg	1	--	int1		0	--	--	--	--
rs104267781,2	A	--	49260911(+)	aacccC/Tgggtc	1	--	int1		0	--	--	--	--
rs104266061,2	A	--	49260928(+)	aggagA/Gggctg	1	--	int1 trp3		0	--	--	--	--
rs99171181,2	C	--	49260964(+)	aggagA/Gggctg	1	--	int1 trp3		0	--	--	--	--

HapMap Linkage Disequilibrium report for FGF21 (49259344 - 49261582 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FGF21
     2 CNVs: 5107 32261

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF21

DNA2.0 Custom Variant and Variant Library Synthesis for FGF21

Disorders / Diseases
for FGF21 gene

16 diseases for FGF21

1 Novoseek disease relationship for FGF21 gene    About this table

Publications
for FGF21 gene

PubMed articles for FGF21 gene, integrated from 9 sources (see all 98): (articles sorted by number of sources associating them with FGF21)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. (PubMed id 10858549)^{1, 2, 3} Nishimura T.... Itoh N. (2000)
2. Different roles of N- and C- termini in the functional activity of FGF21. (PubMed id 19117008)^{1, 2, 9} Micanovic R.... Kharitonenkov A. (2009)
3. C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. (PubMed id 18829467)^{1, 2} Wu X....Li Y. (2008)
4. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. (PubMed id 17623664)^{1, 2} Kurosu H....Kuro-o M. (2007)
5. FGF-21 as a novel metabolic regulator. (PubMed id 15902306)^{1, 2} Kharitonenkov A.... Shanafelt A.B. (2005)
6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
8. Serum fibroblast growth factor 21 levels in gestation al diabetes mellitus in relation to insulin resistance and dyslipidemia. (PubMed id 19699495)^{1, 9} Stein S....Fasshauer M. (2010)
9. Fibroblast growth factor-21 may mediate growth hormon e resistance in anorexia nervosa. (PubMed id 19926712)^{1, 9} Fazeli P.K....Klibanski A. (2010)
10. Serum fibroblast growth factor 21 is associated with adverse lipid profiles and gamma-glutamyltransferase but not insulin sensitivit y in Chinese subjects. (PubMed id 19318452)^{1, 9} Li H....Jia W. (2009)

External Searches for FGF21 gene

Genome Databases showing FGF21 gene

Other Databases showing FGF21 gene

Specialized Databases showing FGF21 gene

Products
for FGF21 gene