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FGF21 Gene(Protein Coding)

Fibroblast Growth Factor 21

GCID:
GC19P048756
GIFtS:
60
Genes Participants
UDN Logo

Aliases for FGF21 Gene

Aliases for FGF21 Gene

  • Fibroblast Growth Factor 21 2 3 5
  • FGF-21 4

External Ids for FGF21 Gene

Previous GeneCards Identifiers for FGF21 Gene

  • GC19P049818
  • GC19P049626
  • GC19P053934
  • GC19P053950
  • GC19P053951
  • GC19P049259
  • GC19P045638

Summaries for FGF21 Gene

Entrez Gene Summary for FGF21 Gene

  • Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]

GeneCards Summary for FGF21 Gene

FGF21 (Fibroblast Growth Factor 21) is a Protein Coding gene. Diseases associated with FGF21 include Overnutrition and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are GPCR Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF19.

UniProtKB/Swiss-Prot for FGF21 Gene

  • Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.

Gene Wiki entry for FGF21 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF21 Gene

Genomics for FGF21 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FGF21 Gene

Enhancers for FGF21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G048724 1.5 Ensembl ENCODE dbSUPER 12.5 -29.8 -29758 3.5 HDGF ATF1 CREB3L1 ETS1 ZNF766 ELK1 ZNF143 FOS SP3 YY2 FUT2 PRR12 IZUMO1 ADM5 FUT1 FGF21 PIH1D1 SEC1P DBP BCAT2
GH19G048768 1.5 Ensembl ENCODE dbSUPER 0.4 +16.3 16325 6.8 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B YY1 TCF12 ZNF121 FOS FUT2 IZUMO1 RASIP1 BCAT2 MAMSTR SEC1P DBP DKKL1 TULP2 NUCB1
GH19G048780 1.6 Ensembl ENCODE dbSUPER 0.3 +26.2 26152 2.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 ARID4B ZNF766 ZNF143 FOS PRR12 PIH1D1 GRWD1 SNORD35A DKKL1 KDELR1 SNORD35B CYTH2 ENSG00000268093 RPS11
GH19G048784 0.8 ENCODE 0.3 +29.2 29210 0.2 HDAC1 ELF3 HDGF ATF1 FOXA2 RB1 ARNT RAD21 GATA2 EGR1 GC19P048785 FGF21
GH19G048775 0.7 ENCODE dbSUPER 0.3 +21.1 21117 1.9 BCOR ZNF121 RASIP1 IZUMO1 BCAT2 DBP SEC1P FUT2 GC19P048785 FGF21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGF21 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FGF21 gene promoter:

Genomic Location for FGF21 Gene

Chromosome:
19
Start:
48,755,559 bp from pter
End:
48,758,330 bp from pter
Size:
2,772 bases
Orientation:
Plus strand

Genomic View for FGF21 Gene

Genes around FGF21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF21 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FGF21 Gene

Proteins for FGF21 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FGF21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSA1-FGF21_HUMAN
    Recommended name:
    Fibroblast growth factor 21
    Protein Accession:
    Q9NSA1
    Secondary Accessions:
    • Q8N683

    Protein attributes for FGF21 Gene

    Size:
    209 amino acids
    Molecular mass:
    22300 Da
    Quaternary structure:
    • Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4.

neXtProt entry for FGF21 Gene

Post-translational modifications for FGF21 Gene

No Post-translational modifications

Other Protein References for FGF21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF21 Gene

Domains & Families for FGF21 Gene

Protein Domains for FGF21 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FGF21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NSA1

UniProtKB/Swiss-Prot:

FGF21_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF21: view

No data available for Gene Families for FGF21 Gene

Function for FGF21 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FGF21 Gene

UniProtKB/Swiss-Prot Function:
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.

Gene Ontology (GO) - Molecular Function for FGF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0005515 protein binding IPI 18829467
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with FGF21: view
genes like me logo Genes that share phenotypes with FGF21: view

Animal Models for FGF21 Gene

MGI Knock Outs for FGF21:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGF21

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGF21 Gene

Localization for FGF21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF21 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF21 gene
Compartment Confidence
cytosol 5
extracellular 5
peroxisome 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for FGF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10858549
GO:0005615 extracellular space IEA --
GO:0005623 cell IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FGF21: view

Pathways & Interactions for FGF21 Gene

genes like me logo Genes that share pathways with FGF21: view

Gene Ontology (GO) - Biological Process for FGF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10858549
GO:0007267 cell-cell signaling TAS 10858549
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway IEA --
GO:0010898 positive regulation of triglyceride catabolic process IEA --
genes like me logo Genes that share ontologies with FGF21: view

No data available for SIGNOR curated interactions for FGF21 Gene

Drugs & Compounds for FGF21 Gene

Products:

  1. Drug

(5) Drugs for FGF21 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Liver Extracts Pharma 4067
Mitogens Pharma 1617
Vitamins Pharma 5282
tyrosine Nutra 699

(1) Additional Compounds for FGF21 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF21: view

Transcripts for FGF21 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FGF21 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF21 Gene

Fibroblast growth factor 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF21 Gene

No ASD Table

Relevant External Links for FGF21 Gene

GeneLoc Exon Structure for
FGF21
ECgene alternative splicing isoforms for
FGF21

Expression for FGF21 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF21 Gene

mRNA expression in normal human tissues for FGF21 Gene
mRNA expression by BioGPS for FGF21 GenemRNA expression by GTEx for FGF21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF21 Gene

This gene is overexpressed in Liver (x51.4).

NURSA nuclear receptor signaling pathways regulating expression of FGF21 Gene:

FGF21

SOURCE GeneReport for Unigene cluster for FGF21 Gene:

Hs.283015

Evidence on tissue expression from TISSUES for FGF21 Gene

  • Lung(4)
  • Liver(3.1)
  • Blood(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with FGF21: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF21 Gene

Orthologs for FGF21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FGF21 34 35
  • 98.88 (n)
dog
(Canis familiaris)
 Mammalia FGF21 34 35
  • 83.09 (n)
cow
(Bos Taurus)
 Mammalia FGF21 34 35
  • 81.66 (n)
mouse
(Mus musculus)
 Mammalia Fgf21 34 16 35
  • 80.13 (n)
rat
(Rattus norvegicus)
 Mammalia Fgf21 34
  • 77.62 (n)
lizard
(Anolis carolinensis)
 Reptilia FGF21 35
  • 38 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii fgf21 35
  • 31 (a)
 OneToOne
Species where no ortholog for FGF21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF21 Gene

ENSEMBL:
Gene Tree for FGF21 (if available)
TreeFam:
Gene Tree for FGF21 (if available)

Paralogs for FGF21 Gene

Paralogs for FGF21 Gene

(1) SIMAP similar genes for FGF21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FGF21: view

Variants for FGF21 Gene

Sequence variations from dbSNP and Humsavar for FGF21 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000350304 -- 48,754,323(+) ATGAC(C/T)GCGGG intron-variant, upstream-variant-2KB
rs1000666062 -- 48,758,612(+) CAGGC(A/G)TGCGC downstream-variant-500B
rs1000789993 -- 48,758,243(+) TATGA(C/T)ATCTC utr-variant-3-prime
rs1001098075 -- 48,758,477(+) TTTTT(C/T)TTTTT downstream-variant-500B
rs1001259416 -- 48,754,010(+) AAACC(C/T)TGTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FGF21 Gene

Variant ID Type Subtype PubMed ID
esv2718686 CNV deletion 23290073
esv2718687 CNV deletion 23290073
esv2718688 CNV deletion 23290073
esv2718689 CNV deletion 23290073
nsv833855 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for FGF21 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF21 Gene

Disorders for FGF21 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FGF21 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
overnutrition
diabetes mellitus, noninsulin-dependent
  • diabetes, type 2
- elite association - COSMIC cancer census association via MalaCards
Search FGF21 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGF21

Genetic Association Database (GAD)
FGF21
Human Genome Epidemiology (HuGE) Navigator
FGF21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF21
genes like me logo Genes that share disorders with FGF21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF21 Gene

Publications for FGF21 Gene

  1. Different roles of N- and C- termini in the functional activity of FGF21. (PMID: 19117008) Micanovic R. … Kharitonenkov A. (J. Cell. Physiol. 2009) 3 4 22 64
  2. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. (PMID: 10858549) Nishimura T. … Itoh N. (Biochim. Biophys. Acta 2000) 2 3 4 64
  3. Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia. (PMID: 19699495) Stein S. … Fasshauer M. (Metab. Clin. Exp. 2010) 3 22 64
  4. Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa. (PMID: 19926712) Fazeli P.K. … Klibanski A. (J. Clin. Endocrinol. Metab. 2010) 3 22 64
  5. Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha. (PMID: 20332535) Wang Y. … Burris T.P. (J. Biol. Chem. 2010) 3 22 64

Products for FGF21 Gene

Sources for FGF21 Gene

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