External Ids for FGF21 Gene
Previous GeneCards Identifiers for FGF21 Gene
Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]
GeneCards Summary for FGF21 Gene
FGF21 (Fibroblast Growth Factor 21) is a Protein Coding gene. Diseases associated with FGF21 include Overnutrition and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Activation of cAMP-Dependent PKA and Metabolism. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF19.
UniProtKB/Swiss-Prot for FGF21 Gene
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.