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FGF21 Gene

protein-coding GIFtS: 54

GC19P053951

fibroblast growth factor 21
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FGF-21 ^³

Descriptions
fibroblast growth factor 21 ^²

External Ids
HGNC: 3678¹
Entrez Gene: 26291²
UniProtKB: Q9NSA1³
Ensembl: ENSG00000105550⁷

Search outside databases for aliases for FGF21 gene

Previous GC identifers: GC19P049818 GC19P049626 GC19P053934 GC19P053950

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FGF21:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF

family members possess broad mitogenic and cell survival activities and are involved in a variety

of biological processes including embryonic development, cell growth, morphogenesis, tissue

repair, tumor growth and invasion. The function of this growth factor has not yet been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: FGF21_HUMAN, Q9NSA1

Function: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose

transporter SLC2A1/GLUT1, but not SLC2A4/GLUT4, expression

Gene Wiki entry for FGF21

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FGF21 gene

Entrez Gene cytogenetic band: 19q13.1-qter Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.1-qter

FGF21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P053951: (about GC identifiers)

Start:	53,951,156 bp from pter
End:	53,953,394 bp from pter
Size:	2,239 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FGF21_HUMAN, Q9NSA1 (See protein sequence)

Recommended Name: Fibroblast growth factor 21 precursor

Size: 209 amino acids; 22300 Da

Subcellular location: Secreted (Potential)

Secondary accessions: Q8N683

REFSEQ proteins: NP_061986.1

ENSEMBL proteins:

ENSP00000222157

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for FGF21 (FGF-21)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FGF21)
	Human Recombinant Proteins from Abnova (FGF21)

OriGene Purified Recombinant Human Protein: FGF21

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	10858549
GO:0005625	soluble fraction	TAS	10858549

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Antibodies for FGF21:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FGF21
	R&D Systems Antibodies for FGF21 (FGF-21)
	Antibodies from Abcam (FGF21), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FGF21)
	Novus Biologicals Antibodies for FGF21

Assays for FGF21:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NSA1

ProtoNet protein and cluster: Q9NSA1

2 Blocks protein families:

IPB002209 Heparin binding growth factor family signature

IPB002348 IL1/HBGF family signature

UniProtKB/Swiss-Prot: FGF21_HUMAN, Q9NSA1

Similarity: Belongs to the heparin-binding growth factors family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FGF21)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FGF21)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019113

Applied Biosystems Silencer® siRNAs for FGF21

Sigma-Aldrich siRNA and siRNA Panels for FGF21

Sigma-Aldrich shRNA for FGF21

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FGF21
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_019113
Myc/DDK tagged cDNA clone in CMV expression vector: NM_019113
untagged cDNA clone in CMV expression vector: NM_019113

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_019113

UniProtKB/Swiss-Prot: FGF21_HUMAN, Q9NSA1

Function: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose

transporter SLC2A1/GLUT1, but not SLC2A4/GLUT4, expression

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008083	growth factor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for FGF21 (Your Favorite Gene powered by Ingenuity)

Clathrin-mediated Endocytosis
FGF Signaling
Bladder Cancer Signaling
Actin Cytoskeleton Signaling

GeneDecks FGF21 for the pathways selected above

About GeneDecksing

5/35 Interacting proteins for FGF21 (ENSP00000222157³) via UniProtKB, MINT, and/or STRING (see all 35 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FGFR4	ENSP00000366412³	STRING (score=.99)
FGFR1	ENSP00000311337³	STRING (score=.963)
FGFR2	ENSP00000333090³	STRING (score=.955)
FGFR3	ENSP00000354170³	STRING (score=.953)
FGF16	ENSP00000346253³	STRING (score=.923)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	10858549
GO:0007267	cell-cell signaling	TAS	10858549

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FGF21

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FGF21)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FGF21)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019113

Sigma-Aldrich siRNA and siRNA Panels for FGF21

Sigma-Aldrich shRNA for FGF21

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_019113

REFSEQ mRNAs for FGF21 gene:

NM_019113.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_019113

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019113
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_019113
                                 untagged cDNA clone in CMV expression vector: NM_019113

Additional cDNA sequence:

AB021975.1 AY359086.1 BC018404.1

1 DOTS entry:

DT.92037354

4 AceView cDNA sequences:

NM_019113 AB021975 AY359086 BC018404

highest scoring ESTs for FGF21:

AB021975 AY359086 BC018404 NM_019113 BE785063 CV024964 CR746717 BF874051

Unigene Cluster for FGF21:

Fibroblast growth factor 21

Hs.283015 [show with all ESTs]

Unigene Representative Sequence: BC018404

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000222157

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FGF21 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FGF21

¹ / ² / ³

2 probe-sets matching FGF21 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
221433_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_019113	0.60	1.00	0.82	1
221433_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGGGACCTT

SOURCE GeneReport for Unigene cluster: Hs.283015

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FGF21 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FGF21¹	--	fibroblast growth factor 21	83.25(n) 85.85(a)	484395 XM_541510.2 XP_541510.2
chimpanzee (Pan troglodytes)	FGF21¹	--	fibroblast growth factor 21	98.88(n) 99.04(a)	468948 XM_524333.2 XP_524333.1
rat (Rattus norvegicus)	Fgf21¹	--	fibroblast growth factor 21	79.25(n) 80.1(a)	170580 NM_130752.1 NP_570108.1
mouse (Mus musculus)	Fgf21^{1, 5}	7⁵	fibroblast growth factor 21^{1, 5}	80.13(n)¹ 79.29(a)¹	56636¹ NM_020013.3¹ NP_064397.1¹ AB025718⁵ AK007574⁵ (see all 6)

About this table Species with no ortholog for FGF21

ENSEMBL Gene Tree for FGF21

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FGF21 gene

FGF19² FGF23²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/39 NCBI SNPs in FGF21 are shown (see all 39 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 50)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs3826820^1,2	A,C,F	53953466(-)	`AGGGGA/GTTGTC`	1	--	ng3¹		5	NS	190
--	rs28405088^1,2	C,F	53953574(+)	`TCTGTC/GACCCA`	1	--	ng3¹		5	NS	190
--	rs11665841^1,2	C,F	53953513(+)	`TCCCAC/TTGGGC`	1	--	ng3¹		5	NS	190
--	rs739320^1,2	C,F	53953180(-)	`CCGGGG/AGTGCG`	1	P/L	mis¹		5	NS	190
--	rs3745706^1,2	C,F	53953450(-)	`CAAGGG/AAGACA`	1	--	ng3¹		5	NS	190
--	rs11665896^1,2	C,F	53953495(+)	`GGTCCG/TAGGGT`	1	--	ng3¹		5	NS	190
--	rs3745707^1,2	C,F	53953425(-)	`TCTTCC/TCTCAG`	1	--	ng3¹		5	NS	190
	rs838130^1,2	A,C,F	53953280(-)	`GAAGCG/ATAGCT`	1	Y/Y	syn¹ ese³		8	NA NS	330
	rs3745710^1,2	C,F	53953079(-)	`AGGCCG/ATGGGC`	1	H/H	syn¹ ese³		5	NS	190
--	rs885662^1,2	C	53953175(-)	`GGTGCG/CGGGGG`	1	P/P	syn¹ ese³		6	MN NS	374

About this table

HapMap Linkage Disequilibrium images for FGF21 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609436

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/24 PubMed articles for FGF21 gene (see all 24 ):

Identification of a novel FGF, FGF-21, preferentially expressed in the liver. (PubMed id 10858549)^{2, 3, 4} Nishimura T.... Itoh N. (2000)
FGF-21 as a novel metabolic regulator. (PubMed id 15902306)^{3, 4} Kharitonenkov A.... Shanafelt A.B. (2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
FGF21 N- and C-termini play different roles in receptor interaction and activation. (PubMed id 19059246)^{1, 3} Yie J....Xu J. (2009)
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. (PubMed id 18252893)^{1, 3} Zhang X....Xu A. (2008)
C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. (PubMed id 18829467)³ Wu X....Li Y. (2008)
Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa. (PubMed id 18559909)³ Dostalova I....Haluzik M. (2008)
Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus. (PubMed id 17926232)³ Chen W.W....Boden G. (2008)
The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man. (PubMed id 18680716)³ Galman C....Rudling M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 26291	HGNC: 3678	AceView: FGF21	Ensembl:ENSG00000105550	euGenes: HUgn26291
ECgene: FGF21	H-InvDB: FGF21

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FGF21	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fgf21/

Licensable Technologies for FGF21
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FGF21:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FGF21-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FGF21		Antibodies for FGF21
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FGF21		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FGF21)
	Antibodies (FGF21)
	Chimera RNAi (FGF21)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (FGF21)
	Antibodies (FGF21)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for FGF21

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FGF21

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FGF21 Gene at Home site.
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FGF21 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for FGF21

Summaries
for FGF21

Genomic Location
for FGF21

Proteins
for FGF21

Protein Domains/
Families
for FGF21

Gene Function
for FGF21

Pathways & Interactions
for FGF21

Drugs & Compounds
for FGF21

Transcripts
for FGF21

Expression
for FGF21

Orthologs
for FGF21

Paralogs
for FGF21

SNPs/Variants
for FGF21

Disorders & Mutations
for FGF21

Medical News
for FGF21

Publications
for FGF21

Search for FGF21

Genome Databases showing FGF21

Other Databases showing FGF21

Specialized Databases showing FGF21

Licensable Technologies
for FGF21

Services
for FGF21

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FGF21 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor FGF21

Summariesfor FGF21

Genomic Locationfor FGF21

Proteinsfor FGF21

Protein Domains/Familiesfor FGF21

Gene Functionfor FGF21

Pathways & Interactionsfor FGF21

Drugs & Compoundsfor FGF21

Transcriptsfor FGF21

Expression for FGF21

Orthologsfor FGF21

Paralogsfor FGF21

SNPs/Variantsfor FGF21

Disorders & Mutationsfor FGF21

Medical Newsfor FGF21

Publicationsfor FGF21

Search for FGF21

Genome Databases showing FGF21

Other Databases showing FGF21

Specialized Databases showing FGF21

Licensable Technologiesfor FGF21

Servicesfor FGF21

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FGF21

Summaries
for FGF21

Genomic Location
for FGF21

Proteins
for FGF21

Protein Domains/
Families
for FGF21

Gene Function
for FGF21

Pathways & Interactions
for FGF21

Drugs & Compounds
for FGF21

Transcripts
for FGF21

Expression
for FGF21

Orthologs
for FGF21

Paralogs
for FGF21

SNPs/Variants
for FGF21

Disorders & Mutations
for FGF21

Medical News
for FGF21

Publications
for FGF21

Licensable Technologies
for FGF21

Services
for FGF21