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Aliases for FGF20 Gene

Aliases for FGF20 Gene

  • Fibroblast Growth Factor 20 2 3
  • FGF-20 3 4
  • RHDA2 3

External Ids for FGF20 Gene

Previous GeneCards Identifiers for FGF20 Gene

  • GC08M016743
  • GC08M016930
  • GC08M016860
  • GC08M016894
  • GC08M015395

Summaries for FGF20 Gene

Entrez Gene Summary for FGF20 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

GeneCards Summary for FGF20 Gene

FGF20 (Fibroblast Growth Factor 20) is a Protein Coding gene. Diseases associated with FGF20 include renal hypodysplasia/aplasia 2 and renal hypodysplasia/aplasia 1. Among its related pathways are PI3K-Akt signaling pathway and PI3K/AKT Signaling in Cancer. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF20 Gene

  • Neurotrophic factor that regulates central nervous development and function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF20 Gene

Genomics for FGF20 Gene

Regulatory Elements for FGF20 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FGF20 Gene

Chromosome:
8
Start:
16,992,169 bp from pter
End:
17,002,181 bp from pter
Size:
10,013 bases
Orientation:
Minus strand

Genomic View for FGF20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FGF20 Gene

Proteins for FGF20 Gene

  • Protein details for FGF20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP95-FGF20_HUMAN
    Recommended name:
    Fibroblast growth factor 20
    Protein Accession:
    Q9NP95
    Secondary Accessions:
    • B2RPH5

    Protein attributes for FGF20 Gene

    Size:
    211 amino acids
    Molecular mass:
    23499 Da
    Quaternary structure:
    • Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

    Three dimensional structures from OCA and Proteopedia for FGF20 Gene

neXtProt entry for FGF20 Gene

Proteomics data for FGF20 Gene at MOPED

Post-translational modifications for FGF20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGF20 Gene

Domains & Families for FGF20 Gene

Suggested Antigen Peptide Sequences for FGF20 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP95

UniProtKB/Swiss-Prot:

FGF20_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF20: view

No data available for Gene Families for FGF20 Gene

Function for FGF20 Gene

Molecular function for FGF20 Gene

UniProtKB/Swiss-Prot Function:
Neurotrophic factor that regulates central nervous development and function.

LifeMap Function Summary for FGF20 Gene

During embryonic development, FGF20 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for FGF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with FGF20: view
genes like me logo Genes that share phenotypes with FGF20: view

Animal Models for FGF20 Gene

MGI Knock Outs for FGF20:

Animal Model Products

miRNA for FGF20 Gene

miRTarBase miRNAs that target FGF20

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF20

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF20 Gene

Localization for FGF20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF20 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF20 Gene COMPARTMENTS Subcellular localization image for FGF20 gene
Compartment Confidence
extracellular 4
nucleus 1

Gene Ontology (GO) - Cellular Components for FGF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular TAS --
genes like me logo Genes that share ontologies with FGF20: view

Pathways & Interactions for FGF20 Gene

SuperPathways for FGF20 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI3K/AKT Signaling in Cancer
4 SHC-mediated cascade-FGFR1
5 FGFR3 mutant receptor activation
genes like me logo Genes that share pathways with FGF20: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for FGF20 Gene

Gene Ontology (GO) - Biological Process for FGF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0007165 signal transduction TAS 10913340
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with FGF20: view

No data available for SIGNOR curated interactions for FGF20 Gene

Drugs & Compounds for FGF20 Gene

No Compound Related Data Available

Transcripts for FGF20 Gene

mRNA/cDNA for FGF20 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF20 Gene

Fibroblast growth factor 20:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF20

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF20 Gene

No ASD Table

Relevant External Links for FGF20 Gene

GeneLoc Exon Structure for
FGF20
ECgene alternative splicing isoforms for
FGF20

Expression for FGF20 Gene

mRNA expression in normal human tissues for FGF20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF20 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.3), Brain - Cerebellar Hemisphere (x6.1), and Brain - Cerebellum (x5.2).

SOURCE GeneReport for Unigene cluster for FGF20 Gene Hs.199905

mRNA Expression by UniProt/SwissProt for FGF20 Gene

Q9NP95-FGF20_HUMAN
Tissue specificity: Predominantly expressed in the cerebellum.
genes like me logo Genes that share expression patterns with FGF20: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FGF20 Gene

Orthologs for FGF20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGF20 35
  • 94 (n)
  • 98.1 (a)
FGF20 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF20 35
  • 92.58 (n)
  • 96.19 (a)
FGF20 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf20 35
  • 89.1 (n)
  • 95.26 (a)
Fgf20 16
Fgf20 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGF20 35
  • 99.84 (n)
  • 100 (a)
FGF20 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf20 35
  • 88.31 (n)
  • 95.26 (a)
oppossum
(Monodelphis domestica)
Mammalia FGF20 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF20 35
  • 82.13 (n)
  • 90.34 (a)
FGF20 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF20 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf20 35
  • 74.68 (n)
  • 80.29 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2769 35
zebrafish
(Danio rerio)
Actinopterygii fgf20b 35
  • 68.63 (n)
  • 80.21 (a)
fgf20a 36
  • 72 (a)
OneToMany
fgf20b 36
  • 77 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 36
  • 26 (a)
OneToMany
Species with no ortholog for FGF20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF20 Gene

ENSEMBL:
Gene Tree for FGF20 (if available)
TreeFam:
Gene Tree for FGF20 (if available)

Paralogs for FGF20 Gene

Paralogs for FGF20 Gene

(19) SIMAP similar genes for FGF20 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FGF20: view

Variants for FGF20 Gene

Sequence variations from dbSNP and Humsavar for FGF20 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1689881 -- 16,994,857(+) ATTTA(A/G)GCAAC intron-variant
rs1689883 -- 16,994,944(+) CTGCT(A/G)TTGTA intron-variant
rs1689884 -- 16,994,947(+) CTATT(C/G)TAATT intron-variant
rs1689885 -- 16,995,106(+) TTGCC(C/T)GATAC intron-variant
rs1689898 -- 16,993,545(+) CACCA(C/G)TGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF20 Gene

Variant ID Type Subtype PubMed ID
dgv2223e1 CNV Complex 17122850
dgv250e55 CNV Gain 17911159
nsv8304 CNV Gain+Loss 18304495
nsv831243 CNV Gain 17160897

Variation tolerance for FGF20 Gene

Residual Variation Intolerance Score: 68.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF20 Gene

HapMap Linkage Disequilibrium report
FGF20
Human Gene Mutation Database (HGMD)
FGF20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF20 Gene

Disorders for FGF20 Gene

MalaCards: The human disease database

(5) MalaCards diseases for FGF20 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
renal hypodysplasia/aplasia 2
  • rhda2
renal hypodysplasia/aplasia 1
  • renal agenesis
renal hypodysplasia
  • renal hypoplasia, isolated
ladd syndrome
  • lacrimoauriculodentodigital syndrome
parkinson disease, late-onset
  • kufor-rakeb syndrome
- elite association
Search FGF20 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGF20_HUMAN
  • Renal hypodysplasia/aplasia 2 (RHDA2) [MIM:615721]: A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy. {ECO:0000269 PubMed:22698282}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FGF20

Genetic Association Database (GAD)
FGF20
Human Genome Epidemiology (HuGE) Navigator
FGF20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF20
genes like me logo Genes that share disorders with FGF20: view

No data available for Genatlas for FGF20 Gene

Publications for FGF20 Gene

  1. Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22. (PMID: 10913340) Kirikoshi H. … Katoh M. (Biochem. Biophys. Res. Commun. 2000) 2 23 67
  2. Genetic variation in FGF20 modulates hippocampal biology. (PMID: 20427658) Lemaitre H. … Weinberger D.R. (J. Neurosci. 2010) 23 67
  3. FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression. (PMID: 19133659) Wider C. … Ross O.A. (Mov. Disord. 2009) 23 67
  4. Mapping of solution components, pH changes, protein stability and the elimination of protein precipitation during freeze-thawing of fibroblast growth factor 20. (PMID: 19505546) Maity H. … Davagnino J. (Int J Pharm 2009) 23 67
  5. Effects of pH and arginine on the solubility and stability of a therapeutic protein (Fibroblast Growth Factor 20): relationship between solubility and stability. (PMID: 19619121) Maity H. … Davagnino J. (Curr Pharm Biotechnol 2009) 23 67

Products for FGF20 Gene

Sources for FGF20 Gene

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