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FGF20 Gene

protein-coding   GIFtS: 60
GCID: GC08M016894

Fibroblast Growth Factor 20

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 201 2
FGF-202 3
RHDA25

External Ids:    HGNC: 36771   Entrez Gene: 262812   Ensembl: ENSG000000785797   OMIM: 6055585   UniProtKB: Q9NP953   

Export aliases for FGF20 gene to outside databases

Previous GC identifers: GC08M016743 GC08M016930 GC08M016860 GC08M015395


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF20 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors
possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes
including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene
product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain,
particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization
of this protein was shown to regulate its receptor binding activity and concentration gradient in the
extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility.
(provided by RefSeq, Oct 2009)

GeneCards Summary for FGF20 Gene:
FGF20 (fibroblast growth factor 20) is a protein-coding gene. Diseases associated with FGF20 include ladd syndrome, and parkinson's disease. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot: FGF20_HUMAN, Q9NP95
Function: Neurotrophic factor that regulates central nervous development and function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF20 gene promoter:
         MyoD   Nkx2-5   Cdc5   Meis-1b   Evi-1   E2F-1   E2F   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF20 promoter sequence
   Search Chromatin IP Primers for FGF20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22

FGF20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF20 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M016894:  view genomic region     (about GC identifiers)

Start:
16,849,678 bp from pter      End:
16,859,690 bp from pter
Size:
10,013 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FGF20_HUMAN, Q9NP95 (See protein sequence)
Recommended Name: Fibroblast growth factor 20  
Size: 211 amino acids; 23499 Da
Subunit: Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their
receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
1 PDB 3D structure from and Proteopedia for FGF20:
3F1R (3D)    
Secondary accessions: B2RPH5

Explore the universe of human proteins at neXtProt for FGF20: NX_Q9NP95

Explore proteomics data for FGF20 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGF20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_062825.1  
    ENSEMBL proteins: 
     ENSP00000180166   ENSP00000428072  
    Reactome Protein details: Q9NP95

    FGF20 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FGF20

    FGF20 Antibody Products:

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    Cloud-Clone Corp. ELISAs for FGF20
    Cloud-Clone Corp. CLIAs for FGF20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam
     IPR028291 FGF20

    Graphical View of Domain Structure for InterPro Entry Q9NP95

    ProtoNet protein and cluster: Q9NP95

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF20_HUMAN, Q9NP95
    Similarity: Belongs to the heparin-binding growth factors family


    FGF20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF20_HUMAN, Q9NP95
    Function: Neurotrophic factor that regulates central nervous development and function

         Summary: 

    During embryonic development, FGF20 as signaling molecule is secreted from the following cells:
                
    Tooth: Primary Enamel Knot Cells (Enamel Knot)

    It affects the following cells:
    Head Mesenchyme: Dental Mesenchymal Cells (Branchial Arch 1)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IEA--
    GO:0008083growth factor activity IEA--
         
    FGF20 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FGF20:
     Increased cell death HMECs cel 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fgf20):
     hearing/vestibular/ear  nervous system 

    FGF20 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fgf20tm1.1Dor for FGF20

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF20

    miRNA
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    miRTarBase miRNAs that target FGF20:
    hsa-mir-433-3p (MIRT001741)

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    Search for qRT-PCR Assays for microRNAs that regulate FGF20
    SwitchGear 3'UTR luciferase reporter plasmidFGF20 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FGF20
    Predesigned siRNA for gene silencing in human, mouse, rat FGF20

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    GenScript: all cDNA clones in your preferred vector: FGF20 (NM_019851)
    Sino Biological Human cDNA Clone for FGF20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF20

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF20_HUMAN, Q9NP95: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    FGF20 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF20 About   (see all 32)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    4Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    5FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR4 ligand binding and activation0.00
    SHC-mediated cascade0.79
    FGFR1 ligand binding and activation0.00
    FGFR2 ligand binding and activation0.74
    Activated point mutants of FGFR20.00
    FRS2-mediated cascade0.70
    Signaling by FGFR2 mutants0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF20 (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for FGF20
        Regulation of Actin Cytoskeleton


    Selected Reactome Pathways for FGF20 (see all 18)
        Signaling by activated point mutants of FGFR1
    FRS2-mediated cascade
    FGFR4 ligand binding and activation
    Negative regulation of FGFR signaling
    Activated point mutants of FGFR2


    Selected Kegg Pathways  (Kegg details for FGF20) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton


    FGF20 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including FGF20: 
              WNT Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGF20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGF20 (ENSP000001801664) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGF1ENSP000003385484STRING: ENSP00000338548
    FGF10ENSP000002646644STRING: ENSP00000264664
    FGF18ENSP000002746254STRING: ENSP00000274625
    FGF19ENSP000002943124STRING: ENSP00000294312
    FGF23ENSP000002378374STRING: ENSP00000237837
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10913340
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007267cell-cell signaling TAS10913340
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0008286insulin receptor signaling pathway TAS--

    FGF20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF20



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FGF20 gene: 
    NM_019851.2  

    Unigene Cluster for FGF20:

    Fibroblast growth factor 20
    Hs.199905  [show with all ESTs]
    Unigene Representative Sequence: NM_019851
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000180166(uc003wxc.1 uc010lsw.1) ENST00000519941

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FGF20
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    GenScript: all cDNA clones in your preferred vector: FGF20 (NM_019851)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FGF20
      QuantiFast Probe-based Assays in human, mouse, rat FGF20

    Additional mRNA sequence: 

    AB030648.1 AB044277.1 BC096720.1 BC098128.1 BC098153.1 BC098339.1 BC127125.1 BC137446.1 
    BC137447.1 BC141979.1 BC141980.1 

    2 DOTS entries:

    DT.434014  DT.121469844 

    13 AceView cDNA sequences:

    BX112207 AA236522 AB030648 NM_019851 BE044225 BQ185761 BE044232 AB044277 
    BE856386 AI272878 AA232729 AI272876 AI674305 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGF20 expression in normal human tissues (normalized intensities)      FGF20 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCACTCTTT
    FGF20 Expression
    About this image


    FGF20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Tooth (Integumentary System)
             Dental Placode Cells Dental Placode
     
     Head Mesenchyme (Muscoskeletal System)
             Ectoderm Cells Branchial Arch 1
     
     Epithelial Cells
             Dental Placode Cells Dental Placode
     
     Ectoderm (Gastrulation Derivatives)
             Ectoderm Cells Branchial Arch 1
    FGF20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.199905

    UniProtKB/Swiss-Prot: FGF20_HUMAN, Q9NP95
    Tissue specificity: Predominantly expressed in the cerebellum

        Pathway & Disease-focused RT2 Profiler PCR Array including FGF20: 
              WNT Signaling Targets in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FGF20 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf201 , 5 fibroblast growth factor 201, 5 89.1(n)1
    95.26(a)1
      8 (23.89 cM)5
    808571  NM_030610.21  NP_085113.21 
     402791665 
    chicken
    (Gallus gallus)
    Aves FGF201 fibroblast growth factor 20 82.13(n)
    90.34(a)
      428779  XM_426335.4  XP_426335.2 
    lizard
    (Anolis carolinensis)
    Reptilia FGF206
    fibroblast growth factor 20
    91(a)
    1 ↔ 1
    5(108077885-108080631)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.27692 Xenopus laevis mRNA for XFGF-20, complete cds 80.51(n)    AB012615.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf20b1 fibroblast growth factor 20b 68.63(n)
    80.21(a)
      564770  NM_001039172.1  NP_001034261.1 


    ENSEMBL Gene Tree for FGF20 (if available)
    TreeFam Gene Tree for FGF20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF20 gene
    FGF122  FGF162  FGF52  FGF42  FGF62  FGF92  FGF32  FGF72  
    FGF112  FGF102  FGF132  FGF222  FGF142  
    Selected SIMAP similar genes for FGF20 using alignment to 3 protein entries:     FGF20_HUMAN (see all proteins) (see all similar genes):
    FGF9    FGF16    FGF5    FGF22    FGF7    FGF13
    FGF12    FGF10    FGF14    FGF1    fgf gene    FGF11
    PRED3    FGF3    KGFLP1    KGFLP2    FGF4    FGF2

    FGF20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF20 (see all 405)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113663151,2
    C,F--16851077(+) GACAA-/TTTTTC 1 -- int13Minor allele frequency- T:0.03NS NA CSA 184
    rs175503041,2
    C,F--16851368(-) CTCATA/GGGAGC 1 -- int11Minor allele frequency- G:0.01NS 178
    rs175502901,2
    C,F--16851406(-) AGCTCC/GGCCTC 1 -- int12Minor allele frequency- G:0.02NS WA 286
    rs175152331,2
    C,F--16851984(-) AAAAAA/-CATGC 1 -- int12Minor allele frequency- -:0.04NS NA 174
    rs175150411,2
    C,F--16855495(-) AAAGACAAGA/
            
    GAATC
    1 -- int11Minor allele frequency- -:0.34NS 178
    rs680539241,2
    C--16855499(-) TTTGA-/AAGAC 
            
    AAGAG
    1 -- int11Minor allele frequency- AAGAC:0.00NA 2
    rs751910921,2
    --16855499(+) CTCTTC/GTCTTT 1 -- int10--------
    rs761416941,2
    C,F--17105069(+) ATAACG/AGAAGT 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1146995111,2
    F--17105082(+) TGTTGT/GTTTTT 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1905197111,2
    --17105113(+) ATCCCA/TGTAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FGF20 (16849678 - 16859690 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FGF20:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv250e55CNV Gain17911159
    nsv831243CNV Gain17160897
    nsv8304CNV Gain+Loss18304495
    dgv2223e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FGF20
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605558   
    OMIM disorders: 615721  
    9 diseases for FGF20:    About MalaCards
    ladd syndrome    parkinson's disease    stomatitis    melanoma
    adenocarcinoma    neuronitis    pancreatitis    colorectal cancer
    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for FGF20:
    Parkinson's disease     LADD syndrome

    FGF20 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for FGF20 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stomatitis 63.7 2 16312140 (1), 18464069 (1)
    parkinson disease 60.6 11 15967032 (2), 17515805 (2), 15122513 (1), 19133659 (1) (see all 8)
    colon cancer 33 1 10913340 (1)
    cancer 19.3 3 10913340 (1), 15592430 (1)

    Genetic Association Database (GAD): FGF20
    Human Genome Epidemiology (HuGE) Navigator: FGF20 (9 documents)

    Export disorders for FGF20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF20 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with FGF20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22. (PubMed id 10913340)1, 2, 3, 9 Kirikoshi H.... Katoh M. (Biochem. Biophys. Res. Commun. 2000)
    2. Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients. (PubMed id 15967032)1, 4, 9 Clarimon J....Singleton A.B. (BMC Neurol 2005)
    3. Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. (PubMed id 18568448)1, 4, 9 Mizuta I....Toda T. (Hum. Genet. 2008)
    4. Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population. (PubMed id 17515805)1, 4, 9 Satake W....Toda T. (Neuroreport 2007)
    5. Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix. (PubMed id 19564416)1, 2, 9 Kalinina J.... Mohammadi M. (Mol. Cell. Biol. 2009)
    6. FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression. (PubMed id 19133659)1, 4, 9 Wider C....Ross O.A. (Mov. Disord. 2009)
    7. Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. (PubMed id 18252210)1, 4, 9 Wang G....Vance J.M. (Am. J. Hum. Genet. 2008)
    8. Gene-gene interaction between FGF20 and MAOB in Parkinson disease. (PubMed id 18205889)1, 4, 9 Gao X....Martin E.R. (Ann. Hum. Genet. 2008)
    9. FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson's disease in Spanish patients. (PubMed id 20471450)1, 4 de Mena L....Alvarez V. (Neurosci. Lett. 2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26281 HGNC: 3677 AceView: FGF20 Ensembl:ENSG00000078579 euGenes: HUgn26281
    ECgene: FGF20 Kegg: 26281 H-InvDB: FGF20

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FGF20 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF20 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf20/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF20 gene:
    Search GeneIP for patents involving FGF20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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