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Aliases for FGF20 Gene

Aliases for FGF20 Gene

  • Fibroblast Growth Factor 20 2 3 5
  • FGF-20 3 4
  • RHDA2 3

External Ids for FGF20 Gene

Previous GeneCards Identifiers for FGF20 Gene

  • GC08M016743
  • GC08M016930
  • GC08M016860
  • GC08M016894
  • GC08M015395

Summaries for FGF20 Gene

Entrez Gene Summary for FGF20 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

GeneCards Summary for FGF20 Gene

FGF20 (Fibroblast Growth Factor 20) is a Protein Coding gene. Diseases associated with FGF20 include Renal Hypodysplasia/Aplasia 2 and Renal Hypodysplasia/Aplasia 1. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF9.

UniProtKB/Swiss-Prot for FGF20 Gene

  • Neurotrophic factor that regulates central nervous development and function.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF20 Gene

Genomics for FGF20 Gene

Regulatory Elements for FGF20 Gene

Enhancers for FGF20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G017050 1 ENCODE 11.2 -50.3 -50305 3.4 FOXA2 MLX ARID4B FEZF1 YY1 SLC30A9 SP5 NFYC MIER2 PPARG MICU3 FGF20 GC08P017125
GH08G017049 0.8 ENCODE 11.1 -47.6 -47605 0.5 SOX13 MAX CEBPG ZNF644 YY1 ZNF652 HOMEZ MIXL1 THAP11 GATAD2A FGF20 MICU3 GC08P017125
GH08G016779 0.9 Ensembl ENCODE 9.8 +222.1 222115 0.3 SCRT1 CTCF ZNF654 REST ZNF2 RAD21 SCRT2 SMC3 CUX1 PRDM1 ZDHHC2 FGF20 GC08M016771 GC08P016788
GH08G017000 0.9 ENCODE 8 +0.5 514 2.1 FOXA2 ARID4B KLF17 GLIS2 SCRT2 EGR2 SP3 ZEB2 ZNF398 ZFP69B FGF20 GC08M016968
GH08G017613 1.6 Ensembl ENCODE dbSUPER 4.5 -614.6 -614624 7.6 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 ZNF143 FOS SP3 MICU3 PDGFRL LOC105379298 LOC100133073 MTUS1 FGF20 ENSG00000277466 MIR548V
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGF20 on UCSC Golden Path with GeneCards custom track

Promoters for FGF20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000221472 880 1400 KLF17 GLIS2 SCRT2 EGR2 SP3 ZEB2 ZNF398 ZFP69B KLF16 ZNF341

Genomic Location for FGF20 Gene

Chromosome:
8
Start:
16,992,169 bp from pter
End:
17,002,181 bp from pter
Size:
10,013 bases
Orientation:
Minus strand

Genomic View for FGF20 Gene

Genes around FGF20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF20 Gene

Proteins for FGF20 Gene

  • Protein details for FGF20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP95-FGF20_HUMAN
    Recommended name:
    Fibroblast growth factor 20
    Protein Accession:
    Q9NP95
    Secondary Accessions:
    • B2RPH5

    Protein attributes for FGF20 Gene

    Size:
    211 amino acids
    Molecular mass:
    23499 Da
    Quaternary structure:
    • Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

    Three dimensional structures from OCA and Proteopedia for FGF20 Gene

neXtProt entry for FGF20 Gene

Post-translational modifications for FGF20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for FGF20

No data available for DME Specific Peptides for FGF20 Gene

Domains & Families for FGF20 Gene

Suggested Antigen Peptide Sequences for FGF20 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP95

UniProtKB/Swiss-Prot:

FGF20_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF20: view

No data available for Gene Families for FGF20 Gene

Function for FGF20 Gene

Molecular function for FGF20 Gene

UniProtKB/Swiss-Prot Function:
Neurotrophic factor that regulates central nervous development and function.

LifeMap Function Summary for FGF20 Gene

During embryonic development, FGF20 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for FGF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005102 receptor binding TAS 11306498
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0008083 growth factor activity ISS,IEA --
genes like me logo Genes that share ontologies with FGF20: view
genes like me logo Genes that share phenotypes with FGF20: view

Human Phenotype Ontology for FGF20 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGF20 Gene

MGI Knock Outs for FGF20:

Animal Model Products

CRISPR Products

miRNA for FGF20 Gene

miRTarBase miRNAs that target FGF20

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF20 Gene

Localization for FGF20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF20 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF20 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FGF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with FGF20: view

Pathways & Interactions for FGF20 Gene

SuperPathways for FGF20 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Apoptotic Pathways in Synovial Fibroblasts
4 Negative regulation of FGFR1 signaling
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF20: view

Gene Ontology (GO) - Biological Process for FGF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction TAS 10913340
GO:0007267 cell-cell signaling TAS 10913340
GO:0008284 positive regulation of cell proliferation TAS 11306498
GO:0008543 fibroblast growth factor receptor signaling pathway TAS,IEA 11306498
genes like me logo Genes that share ontologies with FGF20: view

No data available for SIGNOR curated interactions for FGF20 Gene

Drugs & Compounds for FGF20 Gene

No Compound Related Data Available

Transcripts for FGF20 Gene

mRNA/cDNA for FGF20 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF20 Gene

Fibroblast growth factor 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF20 Gene

No ASD Table

Relevant External Links for FGF20 Gene

GeneLoc Exon Structure for
FGF20
ECgene alternative splicing isoforms for
FGF20

Expression for FGF20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF20 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.3), Brain - Cerebellar Hemisphere (x6.1), and Brain - Cerebellum (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of FGF20 Gene:

FGF20

SOURCE GeneReport for Unigene cluster for FGF20 Gene:

Hs.199905

mRNA Expression by UniProt/SwissProt for FGF20 Gene:

Q9NP95-FGF20_HUMAN
Tissue specificity: Predominantly expressed in the cerebellum.

Evidence on tissue expression from TISSUES for FGF20 Gene

  • Nervous system(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF20 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
  • urinary
Organs:
Head and neck:
  • chin
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • skull
Thorax:
  • esophagus
  • lung
  • trachea
Abdomen:
  • intestine
  • kidney
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • pelvis
  • placenta
  • urethra
  • urinary bladder
  • uterus
  • vagina
General:
  • skin
genes like me logo Genes that share expression patterns with FGF20: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FGF20 Gene

Orthologs for FGF20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF20 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia FGF20 34 35
  • 94 (n)
dog
(Canis familiaris)
Mammalia FGF20 35 34
  • 92.58 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf20 34 16 35
  • 89.1 (n)
rat
(Rattus norvegicus)
Mammalia Fgf20 34
  • 88.31 (n)
oppossum
(Monodelphis domestica)
Mammalia FGF20 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF20 35 34
  • 82.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF20 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf20 34
  • 74.68 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2769 34
zebrafish
(Danio rerio)
Actinopterygii fgf20a 35
  • 72 (a)
OneToMany
fgf20b 35 34
  • 68.63 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 35
  • 26 (a)
OneToMany
Species where no ortholog for FGF20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF20 Gene

ENSEMBL:
Gene Tree for FGF20 (if available)
TreeFam:
Gene Tree for FGF20 (if available)

Paralogs for FGF20 Gene

Paralogs for FGF20 Gene

(19) SIMAP similar genes for FGF20 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FGF20: view

Variants for FGF20 Gene

Sequence variations from dbSNP and Humsavar for FGF20 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs587777282 Pathogenic 16,995,708(+) GTCCA(-/C)ACCTC reference, frameshift-variant
rs12720208 Uncertain significance 16,992,890(-) TAGAT(C/T)ATGAT utr-variant-3-prime
rs1000084734 -- 16,999,264(+) ATTCA(A/G)TCTGT intron-variant
rs1000193361 -- 16,992,825(+) CTTCA(A/G)TCTAC utr-variant-3-prime
rs1000399884 -- 16,992,602(+) TGTTT(A/C)GTTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FGF20 Gene

Variant ID Type Subtype PubMed ID
dgv250e55 CNV gain 17911159
esv2759599 CNV gain 17122850
esv3572602 CNV loss 25503493
nsv1018645 CNV gain 25217958
nsv8304 CNV gain+loss 18304495
nsv831243 CNV gain 17160897

Variation tolerance for FGF20 Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF20 Gene

Human Gene Mutation Database (HGMD)
FGF20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF20 Gene

Disorders for FGF20 Gene

MalaCards: The human disease database

(6) MalaCards diseases for FGF20 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal hypodysplasia/aplasia 2
  • rhda2
renal hypodysplasia/aplasia 1
  • renal agenesis
parkinson disease susceptibility
ladd syndrome
  • lacrimoauriculodentodigital syndrome
mucositis
  • inflammatory disease of mucous membrane
- elite association - COSMIC cancer census association via MalaCards
Search FGF20 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGF20_HUMAN
  • Renal hypodysplasia/aplasia 2 (RHDA2) [MIM:615721]: A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy. {ECO:0000269 PubMed:22698282}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FGF20

Genetic Association Database (GAD)
FGF20
Human Genome Epidemiology (HuGE) Navigator
FGF20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF20
genes like me logo Genes that share disorders with FGF20: view

No data available for Genatlas for FGF20 Gene

Publications for FGF20 Gene

  1. FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression. (PMID: 19133659) Wider C. … Ross O.A. (Mov. Disord. 2009) 3 4 22 46 64
  2. Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. (PMID: 18252210) Wang G. … Vance J.M. (Am. J. Hum. Genet. 2008) 3 4 22 46 64
  3. Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22. (PMID: 10913340) Kirikoshi H. … Katoh M. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  4. Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix. (PMID: 19564416) Kalinina J. … Mohammadi M. (Mol. Cell. Biol. 2009) 3 4 22 64
  5. Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. (PMID: 18568448) Mizuta I. … Toda T. (Hum. Genet. 2008) 3 22 46 64

Products for FGF20 Gene

Sources for FGF20 Gene

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