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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FGF2 Gene

protein-coding   GIFtS: 73
GCID: GC04P123747

fibroblast growth factor 2 (basic)


(Previous symbol: FGFB)
 Explore 315 diseases affiliated with
FGF2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FGF2    

Aliases
for FGF2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fibroblast Growth Factor 2 (Basic)1 2     Basic Fibroblast Growth Factor BFGF2
FGFB1 2 3 5     Fibroblast Growth Factor 22
Heparin-Binding Growth Factor 22 3     Prostatropin1
FGF-22 3     BFGF2
HBGF-22 3     Basic Fibroblast Growth Factor3
BFGF2     

External Ids:    HGNC: 36761   Entrez Gene: 22472   Ensembl: ENSG000001386857   OMIM: 1349205   UniProtKB: P090383   

Export aliases for FGF2 gene to outside databases

Previous GC identifers: GC04P124660 GC04P124027 GC04P124141 GC04P124206 GC04P124105 GC04P119474


Summaries
for FGF2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FGF2:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind
heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological
processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene
contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons,
resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus
and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible
for the paracrine and autocrine effects of this FGF. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038
Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation
and cell migration. Functions as potent mitogen in vitro

Gene Wiki entry for FGF2 (Basic fibroblast growth factor)


Genomic Views
for FGF2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FGF2 gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   c-Jun   LyF-1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FGF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FGF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FGF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q26

FGF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P123747:  view genomic region     (about GC identifiers)

Start:
 123,747,863 bp from pter      End:
 123,819,391 bp from pter
Size:
 71,529 bases      Orientation:
 plus strand

Proteins
for FGF2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038 (See protein sequence)
Recommended Name: Fibroblast growth factor 2 precursor  
Size: 288 amino acids; 30770 Da
Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors
(FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts
with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2
Subcellular location: Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent
mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of
exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the
cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and
KPNB1, as well as CEP57
Miscellaneous: This protein binds heparin more strongly than does aFGF
Sequence caution: Sequence=AAA52448.1; Type=Frameshift; Positions=25, 82, 98, 133; Sequence=AAB21432.2;
Type=Frameshift; Positions=25; Sequence=AAB21432.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The
initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=ABO43041.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=ABO43041.1; Type=Miscellaneous discrepancy; Note=Unusual initiator.
The initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=CAA28027.1; Type=Frameshift;
Positions=25, 102; Sequence=CAA28027.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator
methionine is coded by a non-canonical CTG leucine codon; Sequence=CAA73868.1; Type=Frameshift; Positions=25;
Sequence=CAA73868.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a
non-canonical CTG leucine codon; Sequence=EAX05222.1; Type=Erroneous initiation; Note=Translation N-terminally
extended; Sequence=EAX05222.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is
coded by a non-canonical CTG leucine codon;
6/16 PDB 3D structures from and Proteopedia for FGF2 (see all 16):
1BAS (3D)        1BFB (3D)        1BFC (3D)        1BFF (3D)        1BFG (3D)        1BLA (3D)    
Secondary accessions: A4LBB8 O00527 P78443 Q16443 Q5PY50 Q7KZ11 Q7KZ72 Q9UC54 Q9UCS5 Q9UCS6
Alternative initiation: 4 isoforms:  P09038-4   P09038-1   P09038-2   P09038-3   (Starts at an alternative CUG codon)

Explore the universe of human proteins at neXtProt for FGF2: NX_P09038

Post-translational modifications:

  • Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion1
  • Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09038

    • FGF2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001997.5  
    ENSEMBL proteins: 
     ENSP00000264498  
    Reactome Protein details: P09038
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant FGF2 Protein
    R&D Systems Recombinant & Natural Proteins for FGF2 (FGF basic)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): FGF2
    OriGene Protein Over-expression Lysate: FGF2
    OriGene Custom Protein Services for FGF2 
    GenScript Purified and Recombinant Proteins for FGF2
    Novus Biologicals FGF2 Proteins
    Novus Biologicals FGF2 Lysate
    Sino Biological Recombinant Protein for FGF2
    ProSpec Recombinant Protein for FGF2
    Uscn Proteins for FGF2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--


    FGF2 for ontologies           About GeneDecksing



    FGF2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FGF2
    R&D Systems Antibodies for FGF2 (FGF basic)
    Cell Signaling Technology (CST) Antibodies for FGF2 
    OriGene Antibodies (see all 4): FGF2
    OriGene Custom Antibody Services for FGF2 
    GenScript Superior Antibodies for FGF2
    Novus Biologicals FGF2 Antibodies
    Abcam antibodies for FGF2 
    Uscn Antibodies for FGF2
    ThermoFisher Antibodies for FGF2

    Assay Products for FGF2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Flow Cytometry Kits for FGF2 (FGF basic)         (see all)
    GenScript Custom Assay Services for FGF2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FGF2

    Protein Domains /
    Families
    for FGF2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FGF2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002348 IL1_HBGF
     IPR008996 Cytokine_IL1-like
     IPR002209 GF_heparin-bd

    Graphical View of Domain Structure for InterPro Entry P09038

    ProtoNet protein and cluster: P09038

    2 Blocks protein families:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038
    Similarity: Belongs to the heparin-binding growth factors family


    Function
    for FGF2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038
    Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation
    and cell migration. Functions as potent mitogen in vitro
    Biophysicochemical properties: pH dependence: Retains almost half of its activity after treatment at pH 2.0 for 3 hours
    at 20 degrees Celsius; Temperature dependence: Inactivated after 3 minutes at 60 degrees Celsius or 1 minute at 80
    degrees Celsius;

         Genatlas biochemistry entry for FGF2:
    fibroblast growth factor 2,basic,multifunctional protein,144kDa,expressed by brain,retina cartilage,inducer of
    anteroposterior neural pattern,essential for FGF8 and FGF10 reciprocal regulation loop in limb induction in mouse.
    FGF2 expression is under the control of an antisense transcript (see NUDT6)

         Summary:  
    During embryonic development, FGF2 as signaling molecule is secreted from the following cells: Apical Ectodermal Ridge Cells in Limb Ectoderm, Choroid Plexus Progenitor Cells in Choroid Plexus (see all 8).

    It affects the following cells: Choroid Plexus Progenitor Cells in Choroid Plexus, Dorsal Foregut Endoderm Cells in Dorsal Foregut Endoderm (see all 19).

    FGF2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Retinal progenitor-like cells, Mesoderm embryoid bodies (see all 61).

    miRNA
    Products:            		miRTarBase miRNAs that target FGF2:
    hsa-mir-140-5p (MIRT003962), hsa-mir-16 (MIRT001468)

    OriGene 3'-UTR Clone: FGF2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF2
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF2 (see all 60):
    hsa-miR-576-3p hsa-miR-642a hsa-miR-3152-3p hsa-miR-136 hsa-miR-15a hsa-miR-199a-3p hsa-miR-1245 hsa-miR-503
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF2 (see all 7)
    OriGene shRNA RFP: FGF2
    OriGene siRNA: FGF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FGF2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FGF2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FGF2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FGF2 (NM_002006)
    Sino Biological Human cDNA Clone for FGF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FGF2
    Search LifeMap BioReagents cell lines for FGF2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF2

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IPI10830168
    GO:0005125cytokine activity IDA18059339
    GO:0005245voltage-gated calcium channel activity ----
    GO:0005515protein binding IPI18329368
    GO:0008083growth factor activity IDA18059339


    FGF2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FGF2:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for FGF2: Fgf2tm1Bas Fgf2tm1Doe Fgf2tm2Doe Fgf2tm3Doe Fgf2tm1Zllr
         14 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Fgf2):
     behavior/neurological  cardiovascular system  cellular  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  mortality/aging  muscle  nervous system  normal 
     reproductive system  skeleton  tumorigenesis  vision/eye 

    FGF2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FGF2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/44 super-pathways (see all 44) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1FGFR2c binds to FGF
    8/17 pathways (see all 17)
    		FGFR2c binds to FGF1.00
    		FGFR4 ligand binding and activation0.73
    		FGFR2c ligand binding and activation1.00
    		FGFR1c ligand binding and activation0.71
    		FGFR3c ligand binding and activation0.79
    		Signaling by activated point mutants of FGFR10.71
    		FGFR3 ligand binding and activation0.79
    		FGFR1 ligand binding and activation0.59
    2Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    3Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    4PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    5IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for FGF2
        Development FGF-family signaling
    Development FGFR signaling pathway
    Cell adhesion Plasmin signaling

    5/61 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FGF2 (see all 61)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for FGF2
        Angiogenesis
    Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for FGF2
        Development FGF-family signaling
    Development FGFR signaling pathway
    Cell adhesion Plasmin signaling

    5/11 BioSystems Pathways for FGF2 (see all 11) 
        Neural Crest Differentiation
    Angiogenesis
    MicroRNAs in cardiomyocyte hypertrophy
    Integrated Pancreatic Cancer Pathway
    Endochondral Ossification

    5/58        Reactome Pathways for FGF2 (see all 58)
        FGFR2 ligand binding and activation
    FGFR ligand binding and activation
    Signaling by EGFR in Cancer
    Signaling by FGFR2 mutants
    Downstream signal transduction

    1 PharmGKB Pathway for FGF2
        VEGF Signaling Pathway

    4         Kegg Pathways  (Kegg details for FGF2):
        MAPK signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Melanoma


    FGF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for FGF2 (P090381, 2, 3 ENSP000002644984) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR2P218021, 2, 3, ENSP000004102944EBI-977447,EBI-1028658 MINT-8400514 I2D: score=2 STRING: ENSP00000410294
    FGFBP1Q145121, 3, ENSP000002599884EBI-977447,EBI-953742 I2D: score=4 STRING: ENSP00000259988
    FGFR1P113621, 3, ENSP000003802804EBI-977447,EBI-1058611 I2D: score=2 STRING: ENSP00000380280
    CASP1P294661, 3, ENSP000004100764EBI-977447,EBI-516667 I2D: score=2 STRING: ENSP00000410076
    RPS19P390192, 3, ENSP000002219754MINT-14337 I2D: score=3 STRING: ENSP00000221975
    About this table

    Gene Ontology (GO): 5/67 biological process terms (GO ID links to tree view) (see all 67):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0000187activation of MAPK activity TAS9712850
    GO:0000189MAPK import into nucleus IEA--
    GO:0001525angiogenesis ----
    GO:0001658branching involved in ureteric bud morphogenesis IDA12631064


    FGF2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FGF2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FGF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FGF2

    1 HMDB Compound for FGF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    6 DrugBank Compounds for FGF2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pentosan Polysulfate-- 37300-21-3targetantagonist12375053 8738610 10667230 17071728 7692072
    Sucralfate-- 54182-58-0targetagonist8578198 7948825 1957124 1970337 8578218
    1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid-- --target--17139284 17016423
    1,4-Dideoxy-O2-Sulfo-Glucuronic Acid-- --target--17139284 17016423
    N,O6-Disulfo-Glucosamine-- --target--17139284 17016423
    Sirolimus(-)-Rapamycin (see all 2)53123-88-9targetother/unknown12742462

    10/123 Novoseek chemical compound relationships for FGF2 gene (see all 123)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 92.1 3962 16652197 (9), 10440753 (8), 11249204 (8), 10473871 (8) (see all 99)
    heparan sulfate 80.6 395 18036796 (6), 11956326 (6), 17437011 (4), 1587820 (4) (see all 99)
    matrigel 79.9 122 16374069 (5), 16962729 (3), 17518619 (3), 2066361 (3) (see all 77)
    heparin 76.7 1039 11532694 (11), 1374012 (9), 8311463 (8), 9669548 (7) (see all 99)
    pd 173074 70.9 3 14598292 (3)
    trafermin 70.3 6 17591067 (2), 12403958 (1), 15891629 (1), 15779638 (1) (see all 5)
    cmdb7 69.9 4 9662260 (1), 11514538 (1), 12838326 (1), 11299764 (1)
    thymidine 67.3 160 7645636 (5), 8500333 (2), 11998867 (2), 8544018 (2) (see all 99)
    tyrosine 67.1 286 8304491 (4), 10930570 (4), 12197473 (3), 8780517 (3) (see all 99)
    su5402 66.7 10 15654655 (1), 16179608 (1), 15955829 (1), 15973728 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about FGF2 

    Transcripts
    for FGF2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FGF2 gene: 
    NM_002006.4  

    Unigene Cluster for FGF2:

    Fibroblast growth factor 2 (basic)
    Hs.284244  [show with all ESTs]
    Unigene Representative Sequence: NM_002006
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000264498(uc003iev.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: FGF2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FGF2
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate FGF2 (see all 60):
    hsa-miR-576-3p hsa-miR-642a hsa-miR-3152-3p hsa-miR-136 hsa-miR-15a hsa-miR-199a-3p hsa-miR-1245 hsa-miR-503
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FGF2 (see all 7)
    OriGene shRNA RFP: FGF2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FGF2
    Clone
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    GenScript: all cDNA clones in your preferred vector: FGF2 (NM_002006)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FGF2

    Additional cDNA sequence: 

    AB451321.1 AB451450.1 AY820133.1 BC111737.1 BC118573.1 BC118654.1 J04513.1 M17599.1 
    M27968.1 S47380.1 

    2 DOTS entries:

    DT.416573  DT.121251235 

    24/76 AceView cDNA sequences (see all 76):

    BG190638 AI492978 BG197240 BM970451 NM_007083 BG200726 BG197239 BQ434362 
    AI420564 AI479705 AA953379 BG214454 AI417721 NM_198041 AI401057 AA226913 
    BU619706 AA281223 CA397958 BC009842 BE894167 AF019633 BX097224 BF739878 

    GeneLoc Exon Structure


    Expression
    for FGF2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FGF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTAGTATGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FGF2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/27 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 27) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb EctodermApical Ectodermal Ridge CellsDermis, Ectoderm
    BoneAutopod Epiphyseal EndPrechondrocytesBone, Cartilage
    BoneAutopod Growth PlateHypertrophic ChondrocytesBone, Cartilage
    BoneFacial SuturesFacial Presumptive Suture CellsBone
    BoneRostral Skull Membranous BonesIntramembrenous OsteocytesBone
    BoneRostral SuturesRostral Presumptive Suture CellsBone
    BoneStylopod Epiphyseal EndPrechondrocytesBone, Cartilage
    BoneStylopod Growth PlateHypertrophic ChondrocytesBone, Cartilage
    BoneZeugopod Epiphyseal EndPrechondrocytesBone, Cartilage
    BoneZeugopod Growth PlateHypertrophic ChondrocytesBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    mK3 (Cell line)Kidney
    mK4 (Cell line)Kidney
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Floating aggregates (A scalable, suspensi...)

    See FGF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FGF2

    SOURCE GeneReport for Unigene cluster: Hs.284244

    UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038
    Tissue specificity: Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in
    non-cancerous liver tissue

        SABiosciences Expression via Pathway-Focused PCR Arrays including FGF2 (see all 20): 
              Neurogenesis in human mouse rat
              Wound Healing in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Cell Motility in human mouse rat
              Adipogenesis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for FGF2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FGF2 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FGF21 fibroblast growth factor 2 (basic) 83.98(n)
    92.21(a)    		   396413  NM_205433.1  NP_990764.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FGF26
    		 --
    		 86(a)
    		 1 ↔ 1
    		 5(138567634-138594782)
    African clawed frog
    (Xenopus laevis)    		 Amphibia fgf2-prov2 fibroblast growth factor 2 (basic) 77.68(n)    BC044013.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fgf26
    		 fibroblast growth factor 2
    		 75(a)
    		 1 ↔ 1
    		 14(563298-565810)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 21(a)
    		 1 → many
    		 Group1.40(5135-9659)


    ENSEMBL Gene Tree for FGF2 (if available)
    TreeFam Gene Tree for FGF2 (if available) 

    Paralogs
    for FGF2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FGF2 gene
    FGF172  FGF12  FGF82  FGF182  
    18/19 SIMAP similar genes for FGF2 using alignment to 2 protein entries:     FGF2_HUMAN (see all proteins) (see all similar genes):
    fgf gene    FGFA    FGF1    FGF10    FGF7    FGF6
    KGFLP1    FGF4    FGF16    FGF9    PRED3    FGF8
    FGF5    FGF22    FGF20    FGF12    FGF13    FGF14

    FGF2 for paralogs           About GeneDecksing



    Genomic Variants
    for FGF2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): FGF2
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FGF2
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF2

    Disorders / Diseases
    for FGF2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FGF2 for disorders           About GeneDecksing

    OMIM gene information: 134920    OMIM disorders: --

    20/315 diseases for FGF2 (see all 315):    About MalaCards
    recessive dystrophic epidermolysis bullosa    fibrodysplasia ossificans progressiva    spinal cord injury    intravascular papillary endothelial hyperplasia
    b-cell non-hodgkin lymphoma    intermittent claudication    skeletal muscle regeneration    middle ear cholesteatoma
    non-hodgkin lymphoma    epidermolysis bullosa    maxillary sinus squamous cell carcinoma    proliferative diabetic retinopathy
    mesangial proliferative glomerulonephritis    age related macular degeneration    polyarteritis nodosa    squamous cell carcinoma
    hemolytic-uremic syndrome    cor pulmonale    usual interstitial pneumonia    carpal tunnel syndrome

    8 diseases from the University of Copenhagen DISEASES database for FGF2:
    Cancer     Vascular disease     Keratitis     Brain disease
    Ischemic heart disease     Neurodegenerative disease     Retinal degeneration     Arthritis

    10/96 Novoseek disease relationships for FGF2 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 82 176 11437330 (4), 8988045 (2), 12953927 (2), 17299994 (2) (see all 99)
    tumors 72 1557 11587697 (6), 8988054 (6), 11196179 (6), 12759248 (5) (see all 99)
    corneal neovascularization 65.2 30 16672771 (3), 8927305 (3), 1289616 (2), 12122002 (1) (see all 16)
    solid tumor 59.2 56 11297245 (2), 11248324 (2), 9369936 (2), 11964077 (2) (see all 31)
    metastasis 57.2 211 10987309 (4), 10964050 (3), 20306451 (3), 19080429 (3) (see all 99)
    necrosis 56.8 407 10817565 (2), 12759248 (2), 8334230 (2), 11371962 (2) (see all 99)
    glioma 54.2 209 16723715 (6), 9010219 (6), 1964181 (5), 17562265 (5) (see all 76)
    melanoma 52.3 318 9372243 (6), 16685268 (5), 17214848 (5), 1516057 (5) (see all 99)
    kaposi sarcoma 49.9 27 8728040 (2), 7935812 (2), 9456251 (2), 2199583 (2) (see all 13)
    craniosynostosis 49.7 6 15389579 (1), 9310332 (1), 18067853 (1), 10930313 (1)

    Genetic Association Database (GAD): FGF2
    Human Genome Epidemiology (HuGE) Navigator: FGF2 (39 documents)

    Export disorders for FGF2 gene to outside databases

    Publications
    for FGF2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FGF2 gene, integrated from 9 sources (see all 3872):
    (articles sorted by number of sources associating them with FGF2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. (PubMed id 16257968)1, 2, 9 Xie B.... Wellstein A. (2006)
    2. Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. (PubMed id 11390973)1, 2, 9 Ibrahimi O.A....Mohammadi M. (2001)
    3. Enhancement of fibroblast growth factor (FGF) activity by an FGF- binding protein. (PubMed id 11509569)1, 2, 9 Tassi E.... Wellstein A. (2001)
    4. Tec-kinase-mediated phosphorylation of fibroblast gro wth factor 2 is essential for unconventional secretion. (PubMed id 20230531)1, 2 Ebert A.D....Nickel W. (2010)
    5. Genetic variation in the promoter region of the basic fibroblast growth factor gene. (PubMed id 12590983)1, 4 Beranek M....Vacha J. (2003)
    6. High-affinity binding of basic fibroblast growth factor and platelet- derived growth factor-AA to the core protein of the NG2 proteoglycan. (PubMed id 10358027)1, 2 Goretzki L.... Stallcup W.B. (1999)
    7. Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping. (PubMed id 9925931)1, 3 Kim H.S. (1998)
    8. Receptor specificity of the fibroblast growth factor family. (PubMed id 8663044)1, 2 Ornitz D.M....Goldfarb M. (1996)
    9. High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy. (PubMed id 8885834)1, 2 Moy F.J.... Powers R. (1996)
    10. Refinement of the structure of human basic fibroblast growth factor at 1.6-A resolution and analysis of presumed heparin binding sites by selenate substitution. (PubMed id 7691311)1, 2 Eriksson A.E.... Matthews B.W. (1993)

    External Searches for FGF2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FGF2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2247 HGNC: 3676 AceView: NUDT6 Ensembl:ENSG00000138685 euGenes: HUgn2247
    ECgene: FGF2 Kegg: 2247 H-InvDB: FGF2

    Other Databases showing FGF2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FGF2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FGF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf2/

    Intellectual Property
    for FGF2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FGF2 gene:
    Search GeneIP for patents involving FGF2

    Licensable Technologies for FGF2 gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
     Salk Institute: Transcription Factor Regulating FGF-2 and Variants Thereof
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of FGF2
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