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FGF2 Gene

protein-coding GIFtS: 68

GC04P124027

fibroblast growth factor 2 (basic)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FGFB)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BFGF ^², ³
FGFB ^², ³, ⁵
HBGF-2 ^², ³
prostatropin ^²

Descriptions
Basic fibroblast growth factor ^³
basic fibroblast growth factor bFGF ^²
fibroblast growth factor 2 ^²
fibroblast growth factor 2 (basic) ^²
heparin-binding growth factor 2 ^²

External Ids
HGNC: 3676¹
Entrez Gene: 2247²
UniProtKB: P09038³
Ensembl: ENSG00000138685⁷

Search outside databases for aliases for FGF2 gene

Previous GC identifers: GC04P124660 GC04P124141 GC04P124206 GC04P124105

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FGF2:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF

family members bind heparin and possess broad mitogenic and angiogenic activities. This protein

has been implicated in diverse biological processes, such as limb and nervous system development,

wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites,

and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five

different isoforms with distinct properties. The CUG-initiated isoforms are localized in the

nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly

cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by

RefSeq]

UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038

Function: The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens

for a variety of cell types in vitro. There are differences in the tissue distribution and

concentration of these 2 growth factors

Gene Wiki entry for FGF2 (Basic_fibroblast_growth_factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FGF2 gene

Entrez Gene cytogenetic band: 4q26-q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q26

FGF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P124027: (about GC identifiers)

Start:	123,967,313 bp from pter
End:	124,038,840 bp from pter
Size:	71,528 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038 (See protein sequence)

Recommended Name: Heparin-binding growth factor 2 precursor

Size: 210 amino acids; 22623 Da

Subunit: Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2

Miscellaneous: This protein binds heparin more strongly than does aFGF

Sequence caution: Sequence=AAB21432.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The

initiator methionine is coded by a non-canonical CTG leucine codon;

PDB structures from and Proteopedia :

1BAS (3D)

1BFB (3D)

1BFC (3D)

1BFF (3D)

1BFG (3D)

1BLA (3D)

1BLD (3D)

1CVS (3D)

1EV2 (3D)

1FGA (3D)

1FQ9 (3D)

1II4 (3D)

1IIL (3D)

2BFH (3D)

2FGF (3D)

4FGF (3D)

Secondary accessions: A4LBB8 O00527 P78443 Q16443 Q5PY50 Q7KZ11 Q7KZ72 Q9UC54

Alternative initiation: 3 isoforms: P09038-1 P09038-2 P09038-3

Post-translational modifications:

Several N-termini starting at positions 48, 54, 47 and 65 have been identified by direct sequencing¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001997.5

ENSEMBL proteins:

ENSP00000377879 ENSP00000264498

Human Recombinant Proteins

	Invitrogen human recombinant proteins for FGF2
	Millipore Purified and/or Recombinant FGF2 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for FGF2 (FGF basic)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FGF basic)
	Human Recombinant Proteins from Abnova (FGF2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	10490103
GO:0005615	extracellular space	TAS	2435575

About this table

Antibodies for FGF2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of FGF2
	Sigma-Aldrich Antibodies for FGF2
	R&D Systems Antibodies for FGF2 (FGF basic)
	Cell Signaling Technology (CST) Antibodies for FGF2 (Basic FGF, bFGF)
	Antibodies from Abcam (FGF basic), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FGF2)
	Novus Biologicals Antibodies for FGF2

Assays for FGF2:

	Invitrogen Assays for FGF2
	Millipore Kits and Assays for the Analysis of FGF2
	R&D Systems Flow Cytometry Kits for FGF2 (FGF basic) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: P09038

2 Blocks protein families:

IPB002209 Heparin binding growth factor family signature

IPB002348 IL1/HBGF family signature

UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038

Similarity: Belongs to the heparin-binding growth factors family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FGF2)
		Millipore RNAi Products for the Analysis of FGF2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FGF2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002006

Applied Biosystems Silencer® siRNAs for FGF2

Sigma-Aldrich siRNA and siRNA Panels for FGF2

Sigma-Aldrich shRNA for FGF2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002006
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002006
untagged cDNA clone in CMV expression vector: NM_002006

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002006

UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038

Function: The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens

for a variety of cell types in vitro. There are differences in the tissue distribution and

concentration of these 2 growth factors

Genatlas biochemistry entry for FGF2:

fibroblast growth factor 2,basic,multifunctional protein,144kDa,expressed by brain,retina

cartilage,inducer of anteroposterior neural pattern,essential for FGF8 and FGF10 reciprocal

regulation loop in limb induction in mouse. FGF2 expression is under the control of an antisense

transcript (see NUDT6)

14 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Fgf2):

	behavior/neurological	cellular	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	life span-post-weaning/aging	muscle	nervous system	normal
reproductive system	skeleton	tumorigenesis	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11075807
GO:0008083	growth factor activity	IEA	--
GO:0008201	heparin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for FGF2 (Your Favorite Gene powered by Ingenuity) (see all 6 )

FGF Signaling
Actin Cytoskeleton Signaling
Bladder Cancer Signaling
Clathrin-mediated Endocytosis
Human Embryonic Stem Cell Pluripotency

GeneDecks FGF2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for FGF2

5/174 Interacting proteins for FGF2 (P09038^{1, 2} ENSP00000264498³) via UniProtKB, MINT, and/or STRING (see all 174 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FGFBP1	Q14512¹, ENSP00000371770³	EBI-977447, EBI-953742 STRING (score=.957)
CASP1	P29466¹, ENSP00000260309³	EBI-977447, EBI-516667 STRING (score=.951)
RPS19	P39019²	MINT-14337
RPS19P3	P39019²	MINT-14337
FGFR1	ENSP00000311337³	STRING (score=.999)

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5/23 Gene Ontology (GO) biological process terms (links to tree view) (see all 23 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000186	activation of MAPKK activity	IEA	--
GO:0000187	activation of MAPK activity	TAS	9712850
GO:0001759	induction of an organ	IEA	--
GO:0001934	positive regulation of protein amino acid phosphorylation	IEA	--
GO:0006915	apoptosis	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FGF2
10/23 Novoseek chemical compound relationships for FGF2 gene (see all 23 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
heparan sulfate	80.76	392	18036796 (6), 11956326 (6), 17437011 (4), 1587820 (4) (see all 99)
matrigel	79.90	113	16374069 (5), 16962729 (3), 17518619 (3), 2066361 (3) (see all 72)
cmdb7	70.46	4	9662260 (1), 11514538 (1), 12838326 (1), 11299764 (1)
thymidine	67.81	160	7645636 (5), 8500333 (2), 11998867 (2), 8544018 (2) (see all 99)
tyrosine	66.86	271	8304491 (4), 10930570 (4), 12197473 (3), 8780517 (3) (see all 99)
pd 173074	65.60	3	14598292 (3)
su5402	65.45	9	15654655 (1), 16179608 (1), 15955829 (1), 15973728 (1) (see all 7)
trafermin	64.80	6	17591067 (2), 12403958 (1), 15891629 (1), 15779638 (1) (see all 5)
tgf beta1	63.81	125	18442933 (7), 8602397 (6), 16135988 (5), 17381064 (5) (see all 41)
pd 98,059	59.55	29	12151059 (2), 15631803 (2), 9442043 (1), 10915907 (1) (see all 23)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FGF2)
		Millipore RNAi Products for the Analysis of FGF2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FGF2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002006

Sigma-Aldrich siRNA and siRNA Panels for FGF2

Sigma-Aldrich shRNA for FGF2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002006

REFSEQ mRNAs for FGF2 gene:

NM_002006.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002006

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002006
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002006
                                 untagged cDNA clone in CMV expression vector: NM_002006

Additional cDNA sequence:

AB451321.1 AB451450.1 AY820133.1 BC111737.1 BC118573.1 BC118654.1 J04513.1 L31408.1

M17599.1 M27968.1 S47380.1

4 DOTS entries:

DT.416573 DT.121251235 DT.75103181 DT.100712482

24/76 AceView cDNA sequences (see all 76 ):

BG200726 BU619706 AI420564 NM_198041 BG197239 AI492978 AA953379 AI479705

BQ434362 BG190638 AI401057 BM970451 NM_007083 BG214454 AA226913 BG197240

AI417721 BF739878 BG182217 BG386740 AA868801 BG212846 BG192658 CB148889

highest scoring ESTs for FGF2:

J04513 M27968 AA037148 AA194989 AA195118 AA195208 AA216658 AA218562 AA256481 AA256823

Unigene Cluster for FGF2:

Fibroblast growth factor 2 (basic)

Hs.284244 [show with all ESTs]

Unigene Representative Sequence: NM_002006

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000394350 ENST00000264498

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FGF2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FGF2

¹ / ² / ³

7 probe-sets matching FGF2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1593_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.90	J04513	1.00	1.00	1.00	1
1828_s_at²^{, 3}	U95-A	2	1.00	0.97	0.82	1.11	M27968	1.00	1.00	1.00	1
41806_at²^{, 3}	U95-A	2	1.00	0.97	0.99	1.02	J04513	1.00	1.00	1.00	1
204422_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002006	0.60	1.00	0.82	1
204421_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M27968	1.00	1.00	1.00	1
204422_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204421_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FGF2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGTAGTATGA

SOURCE GeneReport for Unigene cluster: Hs.284244
Expression variation in blood from EXPOLDB for FGF2
UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038
Tissue specificity: Expressed in granulosa and cumulus cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FGF2 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	FGF2¹	--	fibroblast growth factor 2 (basic)	95.27(n) 98.71(a)	281161 NM_174056.2 NP_776481.1
rat (Rattus norvegicus)	Fgf2¹	--	fibroblast growth factor 2	89.18(n) 97.4(a)	54250 NM_019305.1 NP_062178.1
mouse (Mus musculus)	Fgf2^{1, 5}	3 (19.30 cM)⁵	fibroblast growth factor 2^{1, 5}	89.61(n)¹ 95.45(a)¹	14173¹ NM_008006.1¹ NP_032032.1¹ AF065903⁵ AF065904⁵ (see all 27)
chicken (Gallus gallus)	FGF2¹	--	fibroblast growth factor 2 (basic)	83.98(n) 92.21(a)	396413 NM_205433.1 NP_990764.1
African clawed frog (Xenopus laevis)	fgf2-prov²	--	fibroblast growth factor 2 (basic)	77.68(n)	BC044013.1

About this table Species with no ortholog for FGF2

ENSEMBL Gene Tree for FGF2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FGF2 gene

FGF3² FGF1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/508 NCBI SNPs in FGF2 are shown (see all 508 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 175)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs308395^1,2	A,C,F,H	123966392(+)	`TACTGC/GTATTT`	1	--	ng5¹		25	MN EA EU WA NA NS	3936
--	rs308393^1,2	A,C,F,H	123966069(+)	`caacaA/Cgagca`	1	--	ng5¹		5	EU EA WA NS	572
	rs308394^1,2	A,C,F,H	123966333(+)	`AGTTAT/CCCGAT`	1	--	ng5¹		10	MN EU EA WA NS	1174
	rs308398^1,2	A,C,F	123966760(+)	`TCAAGT/ATAGGT`	1	--	ng5¹		9	MN NA NS	912
--	rs41456044^1,2	C,F	123966479(+)	`CAACAT/ATATGT`	1	--	ng5¹		7	NS	640
	rs308397^1,2	C,F	123966651(+)	`TAACAA/GTTTAG`	1	--	ng5¹		1	NS	152
--	rs41440644^1,2	C,F	123966883(+)	`ATGCCC/ACACTT`	1	--	ng5¹		7	NS	636
--	rs6829351^1,2	C,F	123965606(+)	`actttG/Cggtct`	1	--	ng5¹		1	NS	174
	rs308396^1,2	C,F	123966630(+)	`ACTCTC/TTCTCC`	1	--	ng5¹ trp³		2	MN NS	330
--	rs6830094^1,2	C,F	123966180(+)	`TAGAAA/TTGCAT`	1	--	ng5¹		1	NS	170

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HapMap Linkage Disequilibrium images for FGF2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 134920

10/96 Novoseek disease relationships for FGF2 gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization	82.22	172	11437330 (4), 8988045 (2), 12953927 (2), 17299994 (2) (see all 99)
tumors	72.02	1496	11587697 (6), 8988054 (6), 11196179 (6), 12759248 (5) (see all 99)
corneal neovascularization	61.94	30	16672771 (3), 8927305 (3), 1289616 (2), 12122002 (1) (see all 16)
solid tumor	60.07	56	11297245 (2), 11248324 (2), 9369936 (2), 11964077 (2) (see all 31)
metastasis	57.42	195	10987309 (4), 10964050 (3), 8543386 (3), 19080429 (3) (see all 99)
necrosis	56.95	386	10817565 (2), 12759248 (2), 8334230 (2), 11371962 (2) (see all 99)
glioma	54.98	202	16723715 (6), 9010219 (6), 17562265 (6), 1964181 (5) (see all 73)
melanoma	52.90	307	9372243 (6), 16685268 (5), 17214848 (5), 1516057 (5) (see all 99)
craniosynostosis	50.61	6	15389579 (1), 9310332 (1), 18067853 (1), 10930313 (1)
kaposi sarcoma	49.93	27	8728040 (2), 7935812 (2), 9456251 (2), 2199583 (2) (see all 13)

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Genetic Association Database: FGF2
Human Genome Epidemiology Navigator: FGF2 (10 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/3166 PubMed articles for FGF2 gene (see all 3166 ):

Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. (PubMed id 16257968)^{1, 3, 4} Xie B.... Wellstein A. (2006)
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. (PubMed id 11390973)^{1, 3, 4} Ibrahimi O.A....Mohammadi M. (2001)
Enhancement of fibroblast growth factor (FGF) activity by an FGF- binding protein. (PubMed id 11509569)^{1, 3, 4} Tassi E.... Wellstein A. (2001)
Genetic variation in the promoter region of the basic fibroblast growth factor gene. (PubMed id 12590983)^{3, 6} Beranek M....Vacha J. (2003)
High-affinity binding of basic fibroblast growth factor and platelet- derived growth factor-AA to the core protein of the NG2 proteoglycan. (PubMed id 10358027)^{3, 4} Goretzki L.... Stallcup W.B. (1999)
Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping. (PubMed id 9925931)^{2, 3} Kim H.S. (1998)
High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy. (PubMed id 8885834)^{3, 4} Moy F.J.... Powers R. (1996)
Refinement of the structure of human basic fibroblast growth factor at 1.6-A resolution and analysis of presumed heparin binding sites by selenate substitution. (PubMed id 7691311)^{3, 4} Eriksson A.E.... Matthews B.W. (1993)
Reverse transcription with nested polymerase chain reaction shows expression of basic fibroblast growth factor transcripts in human granulosa and cumulus cells from in vitro fertilisation patients. (PubMed id 1417798)^{3, 4} Watson R....Thomas E.J. (1992)
Crystal structure of basic fibroblast growth factor at 1.6-A resolution. (PubMed id 1769963)^{3, 4} Ago H.... Katsube Y. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2247	HGNC: 3676	AceView: NUDT6	Ensembl:ENSG00000138685	euGenes: HUgn2247
ECgene: FGF2	H-InvDB: FGF2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FGF2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fgf2/

Licensable Technologies for FGF2
(Available from WIS Yeda, Salk, Tufts)

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Licensable Technologies for FGF2 gene:

	Weizmann Institute:	Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
	Salk Institute:	Transcription Factor Regulating FGF-2 and Variants Thereof

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for FGF2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FGF2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FGF2		Antibodies for FGF2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FGF2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FGF2)
	Antibodies (FGF2)
	Chimera RNAi (FGF2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for FGF2 (Basic FGF, bFGF)

	Recombinant Proteins (FGF basic)
	Antibodies (FGF basic)

Search OriGene for FGF2

Search Tocris compounds for FGF2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FGF2

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

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FGF2 Gene at Home site.
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FGF2 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for FGF2

Summaries
for FGF2

Genomic Location
for FGF2

Proteins
for FGF2

Protein Domains/
Families
for FGF2

Gene Function
for FGF2

Pathways & Interactions
for FGF2

Drugs & Compounds
for FGF2

Transcripts
for FGF2

Expression
for FGF2

Orthologs
for FGF2

Paralogs
for FGF2

SNPs/Variants
for FGF2

Disorders & Mutations
for FGF2

Medical News
for FGF2

Publications
for FGF2

Search for FGF2

Genome Databases showing FGF2

Other Databases showing FGF2

Specialized Databases showing FGF2

Licensable Technologies
for FGF2

Services
for FGF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FGF2 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor FGF2

Summariesfor FGF2

Genomic Locationfor FGF2

Proteinsfor FGF2

Protein Domains/Familiesfor FGF2

Gene Functionfor FGF2

Pathways & Interactionsfor FGF2

Drugs & Compoundsfor FGF2

Transcriptsfor FGF2

Expression for FGF2

Orthologsfor FGF2

Paralogsfor FGF2

SNPs/Variantsfor FGF2

Disorders & Mutationsfor FGF2

Medical Newsfor FGF2

Publicationsfor FGF2

Search for FGF2

Genome Databases showing FGF2

Other Databases showing FGF2

Specialized Databases showing FGF2

Licensable Technologiesfor FGF2

Servicesfor FGF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FGF2

Summaries
for FGF2

Genomic Location
for FGF2

Proteins
for FGF2

Protein Domains/
Families
for FGF2

Gene Function
for FGF2

Pathways & Interactions
for FGF2

Drugs & Compounds
for FGF2

Transcripts
for FGF2

Expression
for FGF2

Orthologs
for FGF2

Paralogs
for FGF2

SNPs/Variants
for FGF2

Disorders & Mutations
for FGF2

Medical News
for FGF2

Publications
for FGF2

Licensable Technologies
for FGF2

Services
for FGF2