Aliases for FGF2 Gene
External Ids for FGF2 Gene
Previous HGNC Symbols for FGF2 Gene
Previous GeneCards Identifiers for FGF2 Gene
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGF2 Gene
FGF2 (Fibroblast Growth Factor 2) is a Protein Coding gene. Diseases associated with FGF2 include Corneal Neovascularization and Crouzon Syndrome. Among its related pathways are PI-3K cascade-FGFR3 and p70S6K Signaling. GO annotations related to this gene include cytokine activity and heparin binding. An important paralog of this gene is FGF1.
UniProtKB/Swiss-Prot for FGF2 Gene
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (PubMed:23469107).