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FGF2 Gene

protein-coding   GIFtS: 72
GCID: GC04P123747

Fibroblast Growth Factor 2 (Basic)


(Previous symbol: FGFB)
  See FGF2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor 2 (Basic)1 2     Basic Fibroblast Growth Factor BFGF2
FGFB1 2 3 5     Fibroblast Growth Factor 22
Heparin-Binding Growth Factor 22 3     prostatropin2
FGF-22 3     bFGF3
HBGF-22 3     Basic Fibroblast Growth Factor3
BFGF2     

External Ids:    HGNC: 36761   Entrez Gene: 22472   Ensembl: ENSG000001386857   OMIM: 1349205   UniProtKB: P090383   

Export aliases for FGF2 gene to outside databases

Previous GC identifers: GC04P124660 GC04P124027 GC04P124141 GC04P124206 GC04P124105 GC04P119474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FGF2 Gene:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind
heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse
biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for
this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG
initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are
localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly
cytosolic and is responsible for the paracrine and autocrine effects of this FGF. (provided by RefSeq, Jul 2008)

GeneCards Summary for FGF2 Gene:
FGF2 (fibroblast growth factor 2 (basic)) is a protein-coding gene. Diseases associated with FGF2 include intravascular papillary endothelial hyperplasia, and embryonal cancer. GO annotations related to this gene include heparin binding and cytokine activity. An important paralog of this gene is FGF1.

UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038
Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell
differentiation and cell migration. Functions as potent mitogen in vitro

Gene Wiki entry for FGF2 (Basic fibroblast growth factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FGF2 gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   c-Jun   LyF-1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFGF2 promoter sequence
   Search Chromatin IP Primers for FGF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FGF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q26

FGF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FGF2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P123747:  view genomic region     (about GC identifiers)

Start:
123,747,863 bp from pter      End:
123,819,391 bp from pter
Size:
71,529 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038 (See protein sequence)
Recommended Name: Fibroblast growth factor 2 precursor  
Size: 288 amino acids; 30770 Da
Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth
factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as
coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2
Miscellaneous: This protein binds heparin more strongly than does aFGF
Sequence caution: Sequence=AAA52448.1; Type=Frameshift; Positions=25, 82, 98, 133; Sequence=AAB21432.2;
Type=Frameshift; Positions=25; Sequence=AAB21432.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The
initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=ABO43041.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=ABO43041.1; Type=Miscellaneous discrepancy;
Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon;
Sequence=CAA28027.1; Type=Frameshift; Positions=25, 102; Sequence=CAA28027.1; Type=Miscellaneous discrepancy;
Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon;
Sequence=CAA73868.1; Type=Frameshift; Positions=25; Sequence=CAA73868.1; Type=Miscellaneous discrepancy;
Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon;
Sequence=EAX05222.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAX05222.1;
Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG
leucine codon;
Selected PDB 3D structures from and Proteopedia for FGF2 (see all 17):
1BAS (3D)        1BFB (3D)        1BFC (3D)        1BFF (3D)        1BFG (3D)        1BLA (3D)    
Secondary accessions: A4LBB8 O00527 P78443 Q16443 Q5PY50 Q7KZ11 Q7KZ72 Q9UC54 Q9UCS5 Q9UCS6
Alternative initiation: 4 isoforms:  P09038-4   P09038-1   P09038-2   P09038-3   (Starts at an alternative CUG codon)

Explore the universe of human proteins at neXtProt for FGF2: NX_P09038

Explore proteomics data for FGF2 at MOPED

Post-translational modifications: 

  • Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion1
  • Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FGF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001997.5  
    ENSEMBL proteins: 
     ENSP00000264498   ENSP00000477134  
    Reactome Protein details: P09038

    FGF2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant FGF2 Protein
    R&D Systems Recombinant & Natural Proteins for FGF2 (FGF basic)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for FGF2
    OriGene Protein Over-expression Lysate for FGF2
    OriGene MassSpec for FGF2
    OriGene Custom Protein Services for FGF2
    GenScript Purified and Recombinant Proteins for FGF2
    Novus Biologicals FGF2 Proteins
    Novus Biologicals FGF2 Lysate
    Sino Biological Recombinant Protein for FGF2
    Sino Biological Cell Lysate for FGF2
    ProSpec Recombinant Protein for FGF2
    Cloud-Clone Corp. Proteins for FGF2

     
    eBioscience Proteins for FGF2: (see all 2
                        Human FGF basic (FGF-2) Recombinant Protein 5 ug

     
    antibodies-online proteins for FGF2 (177 products) 

     
    antibodies-online peptides for FGF2

    FGF2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FGF2
    R&D Systems Antibodies for FGF2 (FGF basic)
    Cell Signaling Technology (CST) Antibodies for FGF2 
    OriGene Antibodies for FGF2
    OriGene Custom Antibody Services for FGF2
    Novus Biologicals FGF2 Antibodies
    Abcam antibodies for FGF2
    Cloud-Clone Corp. Antibodies for FGF2
    ThermoFisher Antibodies for FGF2
    LSBio Antibodies in human, mouse, rat for FGF2
    antibodies-online antibodies for FGF2 (217 products) 

    FGF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FGF2
    R&D Systems Flow Cytometry Kits for FGF2 (FGF basic)         (see all)
    GenScript Custom Assay Services for FGF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FGF2
    Cloud-Clone Corp. CLIAs for FGF2
    Search eBioscience for ELISAs for FGF2 
    antibodies-online kits for FGF2 (82 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR028142 IL-1_fam/FGF_fam
     IPR008996 Cytokine_IL1-like
     IPR002209 Fibroblast_GF_fam
     IPR028223 FGF2

    Graphical View of Domain Structure for InterPro Entry P09038

    ProtoNet protein and cluster: P09038

    2 Blocks protein domains:
    IPB002209 Heparin binding growth factor family signature
    IPB002348 IL1/HBGF family signature


    UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038
    Similarity: Belongs to the heparin-binding growth factors family


    Find genes that share domains with FGF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FGF2_HUMAN, P09038
    Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell
    differentiation and cell migration. Functions as potent mitogen in vitro
    Biophysicochemical properties: pH dependence: Retains almost half of its activity after treatment at pH 2.0 for 3
    hours at 20 degrees Celsius; Temperature dependence: Inactivated after 3 minutes at 60 degrees Celsius or 1
    minute at 80 degrees Celsius;

         Genatlas biochemistry entry for FGF2:
    fibroblast growth factor 2,basic,multifunctional protein,144kDa,expressed by brain,retina cartilage,inducer of
    anteroposterior neural pattern,essential for FGF8 and FGF10 reciprocal regulation loop in limb induction in
    mouse. FGF2 expression is under the control of an antisense transcript (see NUDT6)

         Summary: 
    During embryonic development, FGF2 as signaling molecule is secreted from the following cells:
          selected tissues (see all 7)      
    Brain: Mature Choroid Plexus Cells (Choroid Plexus), Choroid Plexus Progenitor Cells (Choroid Plexus)
    Ovary: Primary Oocyte (Primordial Follicle)

    It affects the following cells:
          selected tissues (see all 9)      fully expand
    Bone: Immature Endochondral Osteoblasts (Vertebrae), Intramembranous Osteoblasts (Zeugopod Periosteum)      fully expand to see all 7 cells
    Neural Tube: d4 Neural Progenitor Cells (dP3 Neural Domain), Oligodendrocyte Precursor Cells (dP4 Neural Domain)      fully expand to see all 7 cells

    FGF2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 25)      fully expand
    Brain: Dopaminergic neuron-like cells, Brain microvascular endothelial cells       fully expand to see all 21 cells
    Spinal Cord: Motor neuron progenitor cells, Motor neuron-like precursor cells      fully expand to see all 10 cells

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IPI10830168
    GO:0005125cytokine activity IDA18059339
    GO:0005515protein binding IPI10490103
    GO:0008083growth factor activity IDA18059339
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with FGF2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FGF2:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory 

         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Fgf2):
     behavior/neurological  cardiovascular system  cellular  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  mortality/aging  muscle  nervous system  reproductive system 
     skeleton  tumorigenesis  vision/eye 

    Find genes that share phenotypes with FGF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FGF2: Fgf2tm1Bas Fgf2tm1Doe Fgf2tm2Doe Fgf2tm3Doe Fgf2tm1Zllr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FGF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FGF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FGF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FGF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target FGF2:
    hsa-mir-155-5p (MIRT020683), hsa-mir-32-5p (MIRT028310), hsa-mir-186-5p (MIRT021161), hsa-mir-192-5p (MIRT026446), hsa-mir-92a-3p (MIRT049684), hsa-mir-103a-3p (MIRT027141), hsa-mir-503-5p (MIRT007223), hsa-mir-140-5p (MIRT003962), hsa-mir-215-5p (MIRT024732), hsa-mir-16-5p (MIRT001468)

    Block miRNA regulation of human, mouse, rat FGF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FGF2 (see all 60):
    hsa-miR-576-3p hsa-miR-642a hsa-miR-3152-3p hsa-miR-136 hsa-miR-15a hsa-miR-199a-3p hsa-miR-1245 hsa-miR-503
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FGF2
    Predesigned siRNA for gene silencing in human, mouse, rat FGF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FGF2

    Clone
    Products:
         
    OriGene clones in human, mouse for FGF2 (see all 6)
    OriGene ORF clones in mouse, rat for FGF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FGF2 (NM_002006)
    Sino Biological Human cDNA Clone for FGF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FGF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FGF2
    Addgene plasmids for FGF2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FGF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for FGF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FGF2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12276) for FGF2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FGF2_HUMAN, P09038: Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum
    (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the
    plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2
    across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import
    machinery, involving proteins KPNA1 and KPNB1, as well as CEP57
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    cytoskeleton3
    cytosol2
    endoplasmic reticulum2
    plasma membrane2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--

    Find genes that share ontologies with FGF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FGF2 About   (see all 50)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    FGFR4 ligand binding and activation0.00
    SHC-mediated cascade0.79
    FGFR1b ligand binding and activation0.00
    FGFR2 ligand binding and activation0.74
    FGFR1 ligand binding and activation0.00
    FRS2-mediated cascade0.70
    Activated point mutants of FGFR20.00
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82


    Find genes that share SuperPaths with FGF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FGF2 (see all 61)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for FGF2
        Angiogenesis
    Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for FGF2
        Development FGF-family signaling
    Development FGFR signaling pathway
    Cell adhesion Plasmin signaling

    Selected BioSystems Pathways for FGF2 (see all 11)
        MicroRNAs in cardiomyocyte hypertrophy
    Angiogenesis
    Cardiac Progenitor Differentiation
    Neural Crest Differentiation
    Endochondral Ossification


    Selected Reactome Pathways for FGF2 (see all 21)
        Signaling by activated point mutants of FGFR1
    FRS2-mediated cascade
    FGFR4 ligand binding and activation
    Negative regulation of FGFR signaling
    POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation

    1 PharmGKB Pathway for FGF2
        VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for FGF2) (see all 8):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF2 (see all 20): 
              Neurogenesis in human mouse rat
              Wound Healing in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Cell Motility in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FGF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FGF2 (P090381, 2, 3 ENSP000002644984) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFBP1Q145121, 3, ENSP000002599884EBI-977447,EBI-953742 I2D: score=4 STRING: ENSP00000259988
    FGFR2P218021, 3, ENSP000004102944EBI-977447,EBI-1028658 I2D: score=2 STRING: ENSP00000410294
    CSNK2BP678703, ENSP000003650254I2D: score=2 STRING: ENSP00000365025
    ENSG00000224774P678703, ENSP000004156154I2D: score=2 STRING: ENSP00000415615
    ENSG00000206406P678703I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 69):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0000187activation of MAPK activity TAS9712850
    GO:0000189MAPK import into nucleus IEA--
    GO:0001525angiogenesis ----
    GO:0001658branching involved in ureteric bud morphogenesis IDA12631064

    Find genes that share ontologies with FGF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FGF2

    1 HMDB Compound for FGF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    6 DrugBank Compounds for FGF2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pentosan Polysulfate-- 37300-21-3targetantagonist12375053 8738610 10667230 17071728 7692072
    Sucralfate-- 54182-58-0targetagonist8578198 7948825 1957124 1970337 8578218
    1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid-- --target--17139284 17016423
    1,4-Dideoxy-O2-Sulfo-Glucuronic Acid-- --target--17139284 17016423
    N,O6-Disulfo-Glucosamine-- --target--17139284 17016423
    Sirolimus(-)-Rapamycin (see all 2)53123-88-9targetother/unknown12742462

    Selected Novoseek inferred chemical compound relationships for FGF2 gene (see all 123)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 92.1 3962 16652197 (9), 10440753 (8), 11249204 (8), 10473871 (8) (see all 99)
    heparan sulfate 80.6 395 18036796 (6), 11956326 (6), 17437011 (4), 1587820 (4) (see all 99)
    matrigel 79.9 122 16374069 (5), 16962729 (3), 17518619 (3), 2066361 (3) (see all 77)
    heparin 76.7 1039 11532694 (11), 1374012 (9), 8311463 (8), 9669548 (7) (see all 99)
    pd 173074 70.9 3 14598292 (3)
    trafermin 70.3 6 17591067 (2), 12403958 (1), 15891629 (1), 15779638 (1) (see all 5)
    cmdb7 69.9 4 9662260 (1), 11514538 (1), 12838326 (1), 11299764 (1)
    thymidine 67.3 160 7645636 (5), 8500333 (2), 11998867 (2), 8544018 (2) (see all 99)
    tyrosine 67.1 286 8304491 (4), 10930570 (4), 12197473 (3), 8780517 (3) (see all 99)
    su5402 66.7 10 15654655 (1), 16179608 (1), 15955829 (1), 15973728 (1) (see all 7)



    Find genes that share compounds with FGF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FGF2 gene: 
    NM_002006.4  

    Unigene Cluster for FGF2:

    Fibroblast growth factor 2 (basic)
    Hs.284244  [show with all ESTs]
    Unigene Representative Sequence: NM_002006
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264498(uc003iev.1) ENST00000608478
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FGF2 (see all 60):
    hsa-miR-576-3p hsa-miR-642a hsa-miR-3152-3p hsa-miR-136 hsa-miR-15a hsa-miR-199a-3p hsa-miR-1245 hsa-miR-503
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    GenScript: all cDNA clones in your preferred vector: FGF2 (NM_002006)
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    Addgene plasmids for FGF2 
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12276) for FGF2 

    Additional mRNA sequence: 

    AB451321.1 AB451450.1 AY820133.1 BC111737.1 BC118573.1 BC118654.1 J04513.1 L31408.1 
    M17599.1 M27968.1 S47380.1 

    4 DOTS entries:

    DT.416573  DT.121251235  DT.75103181  DT.100712482 

    Selected AceView cDNA sequences (see all 76):

    BG200726 BQ434362 AI492978 BG197240 BM970451 AI401057 AI420564 BG214454 
    AI417721 AI479705 AA953379 AA226913 BG190638 BG197239 NM_198041 BU619706 
    NM_007083 CB148889 BG182217 BC009842 BE894167 AA281223 BG386740 BF739878 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FGF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTAGTATGA
    FGF2 Expression
    About this image


    FGF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 29) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 17 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     
     Tooth (Integumentary System)    fully expand to see all 10 entries
             Inner Enamel Epithelial Cells Dental Enamel
             Stem cells from human exfoliated deciduous teeth (family)
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Hippocampus
    FGF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FGF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.284244

    UniProtKB/Swiss-Prot: FGF2_HUMAN, P09038
    Tissue specificity: Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not
    in non-cancerous liver tissue

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FGF2 (see all 20): 
              Neurogenesis in human mouse rat
              Wound Healing in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Cell Motility in human mouse rat
              Adipogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FGF2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fgf21 , 5 fibroblast growth factor 21, 5 89.61(n)1
    95.45(a)1
      3 (18.41 cM)5
    141731  NM_008006.21  NP_032032.11 
     373125195 
    chicken
    (Gallus gallus)
    Aves FGF21 fibroblast growth factor 2 (basic) 83.98(n)
    92.21(a)
      396413  NM_205433.1  NP_990764.1 
    lizard
    (Anolis carolinensis)
    Reptilia FGF26
    fibroblast growth factor 2 (basic)
    89(a)
    1 ↔ 1
    5(138567634-138594782)
    African clawed frog
    (Xenopus laevis)
    Amphibia fgf2-prov2 fibroblast growth factor 2 (basic) 77.68(n)    BC044013.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fgf21 fibroblast growth factor 2 69.06(n)
    75.82(a)
      404231  NM_212823.2  NP_997988.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bnl6
    branchless
    7(a)
    1 → many
    3R(15619795-15662539)


    ENSEMBL Gene Tree for FGF2 (if available)
    TreeFam Gene Tree for FGF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FGF2 gene
    FGF12  
    Selected SIMAP similar genes for FGF2 using alignment to 2 protein entries:     FGF2_HUMAN (see all proteins) (see all similar genes):
    fgf gene    FGFA    FGF1    FGF10    FGF7    FGF6
    KGFLP1    FGF4    FGF16    FGF9    PRED3    FGF8
    FGF5    FGF22    FGF20    FGF12    FGF13    FGF14

    Find genes that share paralogs with FGF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FGF2 (see all 1466)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816146421,2
    --119472459(+) AAGAGA/GGTTAC 1 -- us2k10--------
    rs1853378111,2
    --119472476(+) TTTCCC/GCAGAT 1 -- us2k10--------
    rs1901448441,2
    --119472477(+) TTCCCC/GAGATC 1 -- us2k10--------
    rs1486450331,2
    --119472524(+) GAGGTA/GCCTTC 1 -- us2k10--------
    rs455887321,2
    C,F--119472573(+) ACACAC/TGGACA 1 -- us2k11Minor allele frequency- T:0.01NS 174
    rs68287631,2
    C,F--119472618(+) taagtC/Tccccc 1 -- us2k15Minor allele frequency- T:0.03NS CSA WA NA 934
    rs68293511,2
    C,F--119472730(+) actttG/Cggtct 1 -- us2k13Minor allele frequency- C:0.05NS WA 820
    rs1411465511,2
    C--119472846(+) GTAATA/GAATGG 1 -- us2k10--------
    rs1861419571,2
    --119473001(+) GGGAGC/TTCGAG 1 -- us2k10--------
    rs1922224471,2
    C--119473075(+) GGTGGG/TGGCGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FGF2 (123747863 - 123819391 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FGF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673015CNV Deletion23128226
    nsv879867CNV Gain21882294

    Human Gene Mutation Database (HGMD): FGF2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FGF2
    DNA2.0 Custom Variant and Variant Library Synthesis for FGF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134920    OMIM disorders: --

    Selected diseases for FGF2 (see all 32):    
    About MalaCards
    intravascular papillary endothelial hyperplasia    embryonal cancer    laryngitis    intermittent claudication
    scleromyxedema    epulis    corneal neovascularization    burn scar
    maxillary sinus squamous cell carcinoma    radiation proctitis    moyamoya disease    gastric ulcer
    hypochondroplasia    myelofibrosis    crouzon syndrome    thymic epithelial neoplasm
    folliculitis    mesangial proliferative glomerulonephritis    learning disability    juvenile nasopharyngeal angiofibroma

    8 diseases from the University of Copenhagen DISEASES database for FGF2:
    Cancer     Vascular disease     Keratitis     Brain disease
    Heart disease     Neurodegenerative disease     Retinal degeneration     Arthritis

    Find genes that share disorders with FGF2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FGF2 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 82 176 11437330 (4), 8988045 (2), 12953927 (2), 17299994 (2) (see all 99)
    tumors 72 1557 11587697 (6), 8988054 (6), 11196179 (6), 12759248 (5) (see all 99)
    corneal neovascularization 65.2 30 16672771 (3), 8927305 (3), 1289616 (2), 12122002 (1) (see all 16)
    solid tumor 59.2 56 11297245 (2), 11248324 (2), 9369936 (2), 11964077 (2) (see all 31)
    metastasis 57.2 211 10987309 (4), 10964050 (3), 20306451 (3), 19080429 (3) (see all 99)
    necrosis 56.8 407 10817565 (2), 12759248 (2), 8334230 (2), 11371962 (2) (see all 99)
    glioma 54.2 209 16723715 (6), 9010219 (6), 1964181 (5), 17562265 (5) (see all 76)
    melanoma 52.3 318 9372243 (6), 16685268 (5), 17214848 (5), 1516057 (5) (see all 99)
    kaposi sarcoma 49.9 27 8728040 (2), 7935812 (2), 9456251 (2), 2199583 (2) (see all 13)
    craniosynostosis 49.7 6 15389579 (1), 9310332 (1), 18067853 (1), 10930313 (1)

    Genetic Association Database (GAD): FGF2
    Human Genome Epidemiology (HuGE) Navigator: FGF2 (39 documents)

    Export disorders for FGF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FGF2 gene, integrated from 10 sources (see all 3909):
    (articles sorted by number of sources associating them with FGF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis. (PubMed id 17204151)1, 4, 9 Butt C....Rahman P. (BMC Musculoskelet Disord 2007)
    2. Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. (PubMed id 16257968)1, 2, 9 Xie B.... Wellstein A. (J. Biol. Chem. 2006)
    3. Effect of basic fibroblast growth factor (FGF2) gene polymorphisms on SSRIs treatment response and side effects. (PubMed id 19586755)1, 4, 9 Kato M....Serretti A. (Eur Neuropsychopharmacol 2009)
    4. Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. (PubMed id 11390973)1, 2, 9 Ibrahimi O.A....Mohammadi M. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    5. Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy. (PubMed id 17997184)1, 4, 9 Beranek M....Vasku A. (Diabetes Res. Clin. Pract. 2008)
    6. Enhancement of fibroblast growth factor (FGF) activity by an FGF- binding protein. (PubMed id 11509569)1, 2, 9 Tassi E.... Wellstein A. (J. Biol. Chem. 2001)
    7. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PubMed id 20641033)1, 4 Lei S.F....Deng H.W. (J. Bone Miner. Res. 2011)
    8. Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up. (PubMed id 21041608)1, 4 van Winkel R. (Arch. Gen. Psychiatry 2011)
    9. Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. (PubMed id 20230531)1, 2 Ebert A.D.... Nickel W. (Traffic 2010)
    10. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2247 HGNC: 3676 AceView: NUDT6 Ensembl:ENSG00000138685 euGenes: HUgn2247
    ECgene: FGF2 Kegg: 2247 H-InvDB: FGF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FGF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FGF2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fgf2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FGF2 gene:
    Search GeneIP for patents involving FGF2

    Licensable Technologies for FGF2 gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
     Salk Institute: Transcription Factor Regulating FGF-2 and Variants Thereof
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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